1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18031249.csml convertedTime:2009.07.01.11:10

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Nod1 and Nod2 in innate immunity and human inflammatory disorders.
Authors Le Bourhis L, Benko S, Girardin SE.
Affiliation Department of Immunology, Medical Sciences Building, University of Toronto, 1King's College Circle, Toronto, Ontario, Canada M5S 1A8.
Abstract Nod (nucleotide-binding oligomerization domain) 1 and Nod2 are intracellularPRMs (pattern-recognition molecules) of the NLR (Nod-like receptor) family.These proteins are implicated in the detection of bacterial peptidoglycan andregulate pro-inflammatory pathways in response to bacteria by inducingsignalling pathways such as NF-kappaB (nuclear factor kappaB) and MAPKs(mitogen-activated protein kinases). The Nod proteins act independently of theTLR (Toll-like receptor) cascade, but potently synergize with the latter totrigger innate immune responses to microbes. Most importantly, mutations in Nod2have been shown to confer susceptibility to several chronic inflammatorydisorders, including Crohn's disease, Blau syndrome and early-onset sarcoidosis,underscoring the role of Nod2 in inflammatory homoeostasis. This reviewsummarizes the most recent findings in the field of Nod1 and Nod2 research.
PMID 18031249
Model Abstract

Entity

G010514:iNOS G010691:CD40 G010859:CD86 G011270:NOD2 G012224:CD80 MO000000022:p38 MO000000023:JNK MO000000058:NF-kappaB MO000000202:p100 MO000000203:NIK MO000000248:IKK MO000000289:TNF-alpha MO000016574:TAK1 MO000016665:IFNgamma MO000017949:RIP2 MO000020434:Nod1 MO000020461:Nod2 MO000034305:Erbin MO000042032:PGN MO000063263:CARD6 e1: e10:Nod1 oligomer:PGN:RIP2 e11:hPepT1 e12:PGN e14:NF-kappaB{active} e15:Nod1 oligomer:PGN e16:Nod1 oligomer:PGN:RIP2:IKK e17:RIP2:CARD6 e18:Nod2 oligomer:PGN e19:Nod2 oligomer:PGN:RIP2 e2: e20:Nod2 oligomer:PGN:RIP2:IKK e21:TAK1:Nod2 e22:SGT1 e23:Nod1:SGT1 e24:Nod2:SGT1 e25:Nod2:Erbin e26:GRIM-19 e27:Nod2:GRIM-19 e28:TNF-alphaR e29:TNF-alpha:TNF-alphaR e3: e30:IFNgammaR e31:IFNgamma:IFNgammaR e32:hBD-2 e33:hBD-2 e34:NO e35:Ligand e36:TLR:Ligand e37:TLR e38:Il-12 e39:H pylori e4: e40:C. jejuni e41:JNK{active} e42:p38{active} e43:Nod2:PGN:NIK e5:Nod1:PGN e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Nod2:PGN e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p5 p6 p7 p8 p9
Model Detail
458.0, 958.0
19.0, 19.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p26

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
511.0, 1123.0
26.0, 26.0

CD40

--

G010691

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p34 p35

--

true true true true

csml-variable:Double

m93612

10

false

infinite

0

unit false false false
TRANSFACG010691

--

Go back
560.0, 1048.0
24.0, 24.0

CD86

--

G010859

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p32 p33

--

true true true true

csml-variable:Double

m93745

10

false

infinite

0

unit false false false
TRANSFACG010859

--

Go back
549.0, 893.0
22.0, 22.0

NOD2

--

G011270

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p21 p23

--

true true true true

csml-variable:Double

m94155

10

false

infinite

0

unit false false false
TRANSFACG011270

--

Go back
437.0, 1077.0
21.0, 21.0

CD80

--

G012224

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p30 p31

--

true true true true

csml-variable:Double

m95018

10

false

infinite

0

unit false false false
TRANSFACG012224

--

Go back
747.0, 783.0
18.0, 18.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p41

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
222.0, 742.0
20.0, 20.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p39

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
646.0, 602.0
20.0, 20.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p9 p14

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
762.0, 486.0
20.0, 20.0

p100

--

MO000000202

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m173

10

false

infinite

0

unit false false false
TRANSPATHMO000000202

--

Go back
750.0, 394.0
20.0, 20.0

NIK

--

MO000000203

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m174

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
353.0, 561.0
22.0, 22.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p13

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1062.0, 818.0
20.0, 20.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
590.0, 290.0
27.0, 27.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1038.0, 946.0
20.0, 20.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
401.0, 509.0
21.0, 21.0

RIP2

--

MO000017949

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p10 p12

true true true true

csml-variable:Double

m2684

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017949

--

Go back
413.0, 341.0
22.0, 22.0

Nod1

--

MO000020434

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p16 p24

true true true true

csml-variable:Double

m4923

10

false

infinite

0

unit false false false
InterProIPR007091
TRANSPATHMO000020434

--

Go back
662.0, 354.0
20.5, 20.5

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
803.0, 315.0
18.0, 18.0

Erbin

--

MO000034305

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m12851

10

false

infinite

0

unit false false false
InterProIPR003591
TRANSPATHMO000034305

--

Go back
487.0, 311.0
18.0, 18.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

p1 p2

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
445.0, 541.0
21.0, 21.0

CARD6

--

MO000063263

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m38143

10

false

infinite

0

unit false false false
TRANSPATHMO000063263

--

Go back
129.75, 128.9969080091176
891.6356363352792, 1294.6549439588246

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
260.0, 507.0
15.794117647058826, 26.323529411764707

Nod1 oligomer:PGN:RIP2

--

e10

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p7

p8

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
490.0, 145.0
12.914873713751168, 29.803554724041152

hPepT1

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
531.0, 71.0
18.0, 18.0

PGN

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
730.0, 638.0
20.0, 20.0

NF-kappaB{active}

--

e14

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5 p9 p14

--

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
327.0, 448.0
18.88235294117647, 31.470588235294127

Nod1 oligomer:PGN

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p7

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
320.0, 615.0
15.794117647058826, 26.323529411764707

Nod1 oligomer:PGN:RIP2:IKK

--

e16

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
478.5, 576.0
19.294617563739372, 23.62606232294617

RIP2:CARD6

--

e17

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p10

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
555.0, 464.0
18.88235294117647, 31.470588235294127

Nod2 oligomer:PGN

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
623.0, 556.0
18.88235294117647, 31.470588235294127

Nod2 oligomer:PGN:RIP2

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
129.75, 128.9969080091176
891.6356363352792, 1294.6549439588246

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
563.0, 696.0
18.88235294117647, 31.470588235294127

Nod2 oligomer:PGN:RIP2:IKK

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
610.5, 237.0
18.069821696383936, 22.126312281286452

TAK1:Nod2

--

e21

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p15

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
252.0, 391.5
23.040000000000003, 17.28

SGT1

--

e22

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p16 p17

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
277.5, 311.0
21.050158306948845, 25.775704049325117

Nod1:SGT1

--

e23

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p16

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
373.5, 259.0
21.050158306948845, 25.775704049325117

Nod2:SGT1

--

e24

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p17

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
808.5, 366.0
22.4300949841693, 27.465422429595062

Nod2:Erbin

--

e25

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p18

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
680.5, 229.0
14.065808009659895, 22.809418394043067

GRIM-19

--

e26

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p19

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
789.5, 247.0
20.944009331778034, 25.645725712381267

Nod2:GRIM-19

--

e27

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p19

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
973.5, 816.0
20.56239015817223, 31.634446397188043

TNF-alphaR

--

e28

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p20

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
974.5, 882.0
18.106555579916684, 35.04494628370972

TNF-alpha:TNF-alphaR

--

e29

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
147.58271272670555, 146.82962073582323
855.970210881868, 1258.9895185054143

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
973.5, 976.0
21.20210896309315, 32.61862917398946

IFNgammaR

--

e30

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p22

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
974.5, 1045.0
19.567857925893446, 37.87327340495505

IFNgamma:IFNgammaR

--

e31

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
318.0, 966.0
35.81314878892734, 19.100346020761247

hBD-2

--

e32

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
250.0, 830.0
11.942001870907388, 27.558465855940124

hBD-2

--

e33

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p25

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
347.0, 750.0
34.51640033641715, 19.55929352396972

NO

--

e34

cso30:c:SmallMolecule

cso30:i:CC_Cytoplasm

--

p27 p28

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
70.0, 955.5
28.303481585832145, 17.453813644596494

Ligand

--

e35

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p29

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
158.5, 1057.0
19.764963823722866, 38.25476869107652

TLR:Ligand

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
152.5, 983.0
22.550087873462214, 34.692442882249566

TLR

--

e37

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p29

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
638.0, 976.0
44.16955017301037, 23.55709342560554

Il-12

--

e38

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

p36 p37

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
59.5, 514.0
19.49460329483052, 28.528687748532473

H pylori

--

e39

cso30:c:Cell

cso30:i:CC_Cytoplasm

--

--

p24

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
180.57323127111096, 178.03686800755779
789.9891737930575, 1196.575023961944

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
59.5, 670.0
21.92463548570346, 32.08483241810263

C. jejuni

--

e40

cso30:c:Cell

cso30:i:CC_Extracellular

--

--

p25

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
294.0, 790.0
20.0, 20.0

JNK{active}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38 p39

--

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
662.0, 814.0
20.0, 20.0

p38{active}

--

e42

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40 p41

--

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
704.5, 444.0
23.153239126445214, 32.30684529271426

Nod2:PGN:NIK

--

e43

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p4

p5

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
486.5, 428.0
19.12314614230962, 23.416097317113817

Nod1:PGN

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
271.0, 813.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
321.29367619468036, 823.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
277.06992643728904, 818.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
277.93705878547314, 819.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
271.0, 813.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
271.0, 813.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
277.93705878547314, 819.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
610.9158804881849, 986.4264696368292
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
534.6082338479803, 1107.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
271.0, 813.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
568.5, 418.0
22.33211131478087, 27.34544242626229

Nod2:PGN

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
380.7511016961721, 1000.6637213250546
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
380.25867587120234, 979.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
401.43298634490145, 1038.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
164.0, 141.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
168.0, 153.7820393372072
807.0845065347537, 1171.8867034884627

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
146.0, 157.0
860.3419604014521, 1238.487740672452

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
486.0, 378.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c5 : 1

m4923*m155701*0.1

nodelay

--

true

0

false

PMID: 18031249,12527755,12871942,12514169,12796777,12791997 Nod1 and Nod2 detect distinct sub-structures from bacterial peptidoglycan. Whereas Nod2 detects MDP (muramyl dipeptide; MurNAc-L-Ala-D-isoGln), the largest peptidoglycan motif common to Gram-negative and Gram-positive bacteria , Nod1 senses meso-DAP (meso-diaminopimelic acid)-containing peptidoglycan , which is more commonly found in Gram-negative bacteria.

Go back
478.0, 482.0
19.0, 19.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m2684*m38143*0.1

nodelay

--

true

0

false

PMID: 18031249,16418290 In overexpression studies, CARD6 has been shown to bind RIP2, but affected Nod-dependent NF-kB activation only modestly

Go back
631.0, 451.0
17.0, 17.0

p6

p11

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 18031249 The current model shows that the oligomerization of Nod proteins following peptidoglycan sensing results in the recruitment of RIP2 (receptor-interacting protein 2), also known as RICK [Rip-like interacting CLARP (caspase-like apoptosis-regulatory protein) kinase], which in turn interacts with the IKK [IkB (inhibitor of NF-kB) kinase] complex, the converging knot of common NF-kB-activating pathways, including TLR-, IL-1- and TNF (tumour necrosis factor)-mediated signalling cascades.

Go back
602.0, 510.0
19.0, 19.0

p7

p12

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m19*m2684*0.1

nodelay

--

true

0

false

PMID: 18031249 The current model shows that the oligomerization of Nod proteins following peptidoglycan sensing results in the recruitment of RIP2 (receptor-interacting protein 2), also known as RICK [Rip-like interacting CLARP (caspase-like apoptosis-regulatory protein) kinase], which in turn interacts with the IKK [IkB (inhibitor of NF-kB) kinase] complex, the converging knot of common NF-kB-activating pathways, including TLR-, IL-1- and TNF (tumour necrosis factor)-mediated signalling cascades.

Go back
502.0, 654.0
19.0, 19.0

p7

p13

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m20*m207*0.1

nodelay

--

true

0

false

PMID: 18031249 The current model shows that the oligomerization of Nod proteins following peptidoglycan sensing results in the recruitment of RIP2 (receptor-interacting protein 2), also known as RICK [Rip-like interacting CLARP (caspase-like apoptosis-regulatory protein) kinase], which in turn interacts with the IKK [IkB (inhibitor of NF-kB) kinase] complex, the converging knot of common NF-kB-activating pathways, including TLR-, IL-1- and TNF (tumour necrosis factor)-mediated signalling cascades.

Go back
622.0, 666.0
19.0, 19.0

p9

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m21*m14*0.1

nodelay

--

true

0

false

PMID: 18031249 The current model shows that the oligomerization of Nod proteins following peptidoglycan sensing results in the recruitment of RIP2 (receptor-interacting protein 2), also known as RICK [Rip-like interacting CLARP (caspase-like apoptosis-regulatory protein) kinase], which in turn interacts with the IKK [IkB (inhibitor of NF-kB) kinase] complex, the converging knot of common NF-kB-activating pathways, including TLR-, IL-1- and TNF (tumour necrosis factor)-mediated signalling cascades.

Go back
661.0, 293.0
21.0, 21.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m4947*m1573*0.1

nodelay

--

true

0

false

PMID: 18031249,15075345 Similarly, overexpressed TAK1 [TGF (transforming growth factor)-b-activated kinase 1] and Nod2 have been shown to interact

Go back
330.0, 390.0
19.0, 19.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m4923*m23*0.1

nodelay

--

true

0

false

PMID: 18031249,17420470,17435760 Two studies have found, using unbiased screens for identifying new Nod partners, that overexpressed Nod1 and Nod2 interact with SGT1 (suppressor of G2 allele of Skp1), a co-chaperone of HSP90 (heat-shock protein 90)

Go back
458.0, 262.0
19.0, 19.0

p16

p17

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m4947*m23*0.1

nodelay

--

true

0

false

PMID: 18031249,17420470,17435760 Two studies have found, using unbiased screens for identifying new Nod partners, that overexpressed Nod1 and Nod2 interact with SGT1 (suppressor of G2 allele of Skp1), a co-chaperone of HSP90 (heat-shock protein 90)

Go back
734.0, 314.0
19.0, 19.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m4947*m12851*0.1

nodelay

--

true

0

false

PMID: 18031249,16203728,16714539 Two other studies have reported the interaction between Nod2 and Erbin, again relying on unbiased screens

Go back
706.0, 286.0
19.0, 19.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m4947*m27*0.1

nodelay

--

true

0

false

PMID: 18031249,15753091 Finally, using a yeast two-hybrid screen, Barnich et al.identified GRIM-19 (gene associated with retinoid-interferon-induced mortality 19) as a Nod2-interacting protein that is important for Nod2-mediated responses

Go back
570.0, 354.0
19.0, 19.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c4 : 1
stoichiometry:c6 : 1

m4947*m155701*0.1

nodelay

--

true

0

false

PMID: 18031249,12527755,12871942,12514169,12796777,12791997 Nod1 and Nod2 detect distinct sub-structures from bacterial peptidoglycan. Whereas Nod2 detects MDP (muramyl dipeptide; MurNAc-L-Ala-D-isoGln), the largest peptidoglycan motif common to Gram-negative and Gram-positive bacteria , Nod1 senses meso-DAP (meso-diaminopimelic acid)-containing peptidoglycan , which is more commonly found in Gram-negative bacteria.

Go back
1061.0, 889.0
21.0, 21.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m230*m29*0.1

nodelay

--

true

0

false

PMID: 18031249,12813035,12671897 Nod1 seems to be more ubiquitously and constitutively expressed in this cell type than Nod2, even though several studies showed the up-regulation of Nod2 by TNFa and IFNg (interferon g) in epithelial cells

Go back
645.0, 909.0
21.0, 21.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 18031249,12813035,12671897 Nod1 seems to be more ubiquitously and constitutively expressed in this cell type than Nod2, even though several studies showed the up-regulation of Nod2 by TNFa and IFNg (interferon g) in epithelial cells

Go back
1045.0, 997.0
21.0, 21.0

p20

p22

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m1639*m31*0.1

nodelay

--

true

0

false

PMID: 18031249,12813035,12671897 Nod1 seems to be more ubiquitously and constitutively expressed in this cell type than Nod2, even though several studies showed the up-regulation of Nod2 by TNFa and IFNg (interferon g) in epithelial cells

Go back
609.0, 1017.0
21.0, 21.0

p21

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 18031249,12813035,12671897 Nod1 seems to be more ubiquitously and constitutively expressed in this cell type than Nod2, even though several studies showed the up-regulation of Nod2 by TNFa and IFNg (interferon g) in epithelial cells

Go back
410.0, 898.0
19.0, 19.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c105 : 1
stoichiometry:c68 : 1

m4923*m40*0.1

nodelay

--

true

0

false

PMID: 18031249,16513653 A recent study has demonstrated that Nod1 plays a key role in the induction of hBD-2 following infection of gastric cells with H. pylori PMID: 18031249,17521327 Similarly, sensing of C. jejuni by Nod1 was shown to induce hBD2 production, resulting in lowered bacterial colonization

Go back
246.0, 890.0
19.0, 19.0

p25

p25

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c106 : 1
stoichiometry:c70 : 1

m33*m41*0.1

nodelay

--

true

0

false

PMID: 18031249,16513653 A recent study has demonstrated that Nod1 plays a key role in the induction of hBD-2 following infection of gastric cells with H. pylori PMID: 18031249,17521327 Similarly, sensing of C. jejuni by Nod1 was shown to induce hBD2 production, resulting in lowered bacterial colonization

Go back
458.0, 890.0
19.0, 19.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m32*m5*0.1

nodelay

--

true

0

false

PMID: 18031249,17579072 iNOS is induced after Nod1 stimulation in mesothelial cells in synergy with IFNg

Go back
294.0, 714.0
19.0, 19.0

p27

p27

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 18031249,16211083,16585574,17579072 n primary macrophages, Nod1 and Nod2 pathways have been shown to induce the formation of NO

Go back
374.0, 698.0
19.0, 19.0

p27

p28

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 18031249,16211083,16585574,17579072 In primary macrophages, Nod1 and Nod2 pathways have been shown to induce the formation of NO

Go back
73.0, 1017.0
21.0, 21.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m36*m38*0.1

nodelay

--

true

0

false

PMID: 18031249,16021602 In human primary DCs, Nod ligands were shown to induce, in synergy with TLR ligands, increased expression of several co-stimulatory molecules, CD80, CD86 and CD40

Go back
530.0, 226.0
19.0, 19.0

p3

p3

cso30:i:ME_Internalization

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m12*m11*0.1

nodelay

--

true

0

false

PMID: 18031249,15521010 hPepT1 (human peptide transporter 1), a transmembrane transporter of di- or tri-peptides, has been shown to internalize MDP

Go back
345.0, 1077.0
21.0, 21.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m5*m37*0.1

nodelay

--

true

0

false

PMID: 18031249,16021602 In human primary DCs, Nod ligands were shown to induce, in synergy with TLR ligands, increased expression of several co-stimulatory molecules, CD80, CD86 and CD40

Go back
497.0, 969.0
21.0, 21.0

p30

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m6*m37*0.1

nodelay

--

true

0

false

PMID: 18031249,16021602 In human primary DCs, Nod ligands were shown to induce, in synergy with TLR ligands, increased expression of several co-stimulatory molecules, CD80, CD86 and CD40

Go back
553.0, 989.0
21.0, 21.0

p30

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m6*m37*0.1

nodelay

--

true

0

false

PMID: 18031249,16021602 In human primary DCs, Nod ligands were shown to induce, in synergy with TLR ligands, increased expression of several co-stimulatory molecules, CD80, CD86 and CD40

Go back
425.0, 969.0
21.0, 21.0

p30

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c92 : 1
stoichiometry:c91 : 1

m5*m37*0.1

nodelay

--

true

0

false

PMID: 18031249,16021602 In human primary DCs, Nod ligands were shown to induce, in synergy with TLR ligands, increased expression of several co-stimulatory molecules, CD80, CD86 and CD40

Go back
381.0, 1101.0
21.0, 21.0

p30

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m37*m5*0.1

nodelay

--

true

0

false

PMID: 18031249,16021602 In human primary DCs, Nod ligands were shown to induce, in synergy with TLR ligands, increased expression of several co-stimulatory molecules, CD80, CD86 and CD40

Go back
513.0, 1045.0
21.0, 21.0

p30

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m37*m6*0.1

nodelay

--

true

0

false

PMID: 18031249,16021602 In human primary DCs, Nod ligands were shown to induce, in synergy with TLR ligands, increased expression of several co-stimulatory molecules, CD80, CD86 and CD40

Go back
486.0, 926.0
19.0, 19.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c101 : 1
stoichiometry:c100 : 1

m37*m5*0.1

nodelay

--

true

0

false

PMID:18031249,16299289 Similarly, Nod and TLR ligands co-operate on DCs to trigger IL-12, a crucial cytokine in Th1 immunity

Go back
582.0, 858.0
19.0, 19.0

p36

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c102 : 1

m37*m6*0.1

nodelay

--

true

0

false

PMID:18031249,16299289 Similarly, Nod and TLR ligands co-operate on DCs to trigger IL-12, a crucial cytokine in Th1 immunity

Go back
246.0, 670.0
19.0, 19.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m17*m42*0.1

nodelay

--

true

0

false

PMID: 18031249,16552041,11463746,17420470 Nod1- and Nod2- dependent pathways also stimulate JNK (c-Jun N-terminal kinase) and p38 MAPK

Go back
330.0, 662.0
19.0, 19.0

p38

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m21*m42*0.1

nodelay

--

true

0

false

PMID: 18031249,16552041,11463746,17420470 Nod1- and Nod2- dependent pathways also stimulate JNK (c-Jun N-terminal kinase) and p38 MAPK

Go back
650.0, 394.0
19.0, 19.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c119 : 1
stoichiometry:c10 : 1

m174*m6*0.1

nodelay

--

true

0

false

PMID: 18031249,16552041 In addition, a direct interaction between Nod2 and NIK (NF-kB-inducing kinase) has been reported to trigger the p100/p52-dependent induction of the non-canonical NF-kB pathway in murine primary macrophages

Go back
662.0, 750.0
19.0, 19.0

p38

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m21*m44*0.1

nodelay

--

true

0

false

PMID: 18031249,16552041,11463746,17420470 Nod1- and Nod2- dependent pathways also stimulate JNK (c-Jun N-terminal kinase) and p38 MAPK

Go back
510.0, 734.0
19.0, 19.0

p38

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m17*m44*0.1

nodelay

--

true

0

false

PMID: 18031249,16552041,11463746,17420470 Nod1- and Nod2- dependent pathways also stimulate JNK (c-Jun N-terminal kinase) and p38 MAPK

Go back
677.0, 517.0
21.0, 21.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c16 : 1
stoichiometry:c120 : 1
stoichiometry:c15 : 1

m14*m173*m46*0.1

nodelay

--

true

0

false

PMID: 18031249,16552041 In addition, a direct interaction between Nod2 and NIK (NF-kB-inducing kinase) has been reported to trigger the p100/p52-dependent induction of the non-canonical NF-kB pathway in murine primary macrophages

Go back
395.0, 431.0
17.0, 17.0

p6

p6

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 18031249 The current model shows that the oligomerization of Nod proteins following peptidoglycan sensing results in the recruitment of RIP2 (receptor-interacting protein 2), also known as RICK [Rip-like interacting CLARP (caspase-like apoptosis-regulatory protein) kinase], which in turn interacts with the IKK [IkB (inhibitor of NF-kB) kinase] complex, the converging knot of common NF-kB-activating pathways, including TLR-, IL-1- and TNF (tumour necrosis factor)-mediated signalling cascades.

Go back
326.0, 510.0
19.0, 19.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m16*m2684*0.1

nodelay

--

true

0

false

PMID: 18031249 The current model shows that the oligomerization of Nod proteins following peptidoglycan sensing results in the recruitment of RIP2 (receptor-interacting protein 2), also known as RICK [Rip-like interacting CLARP (caspase-like apoptosis-regulatory protein) kinase], which in turn interacts with the IKK [IkB (inhibitor of NF-kB) kinase] complex, the converging knot of common NF-kB-activating pathways, including TLR-, IL-1- and TNF (tumour necrosis factor)-mediated signalling cascades.

Go back
258.0, 562.0
19.0, 19.0

p7

p8

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m10*m207*0.1

nodelay

--

true

0

false

PMID: 18031249 The current model shows that the oligomerization of Nod proteins following peptidoglycan sensing results in the recruitment of RIP2 (receptor-interacting protein 2), also known as RICK [Rip-like interacting CLARP (caspase-like apoptosis-regulatory protein) kinase], which in turn interacts with the IKK [IkB (inhibitor of NF-kB) kinase] complex, the converging knot of common NF-kB-activating pathways, including TLR-, IL-1- and TNF (tumour necrosis factor)-mediated signalling cascades.

Go back
394.0, 618.0
19.0, 19.0

p9

p9

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m17*m14*0.1

nodelay

--

true

0

false

PMID: 18031249 The current model shows that the oligomerization of Nod proteins following peptidoglycan sensing results in the recruitment of RIP2 (receptor-interacting protein 2), also known as RICK [Rip-like interacting CLARP (caspase-like apoptosis-regulatory protein) kinase], which in turn interacts with the IKK [IkB (inhibitor of NF-kB) kinase] complex, the converging knot of common NF-kB-activating pathways, including TLR-, IL-1- and TNF (tumour necrosis factor)-mediated signalling cascades.

Go back
435.0, 358.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
669.0, 413.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
505.0, 939.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0, 451.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
597.0, 877.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
178.0, 876.5206955147272

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.0, 445.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
79.0, 539.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
81.0, 699.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
271.46988867442553, 634.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
235.0, 696.5750527097637

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
260.0, 689.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
677.0, 404.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.88914962016696, 675.3271466650748

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
242.0, 683.8

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
309.1228965159425, 681.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
582.0, 717.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
688.4432671425367, 765.9321961470599

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
672.0, 769.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 633.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.8418661386816, 747.5827619729449

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.0, 749.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
591.0, 409.68259732421313

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
695.0641201816035, 476.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
660.0, 545.4906334205524

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.0, 538.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
705.4906334205524, 500.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
420.0, 440.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.55805289534106, 443.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 479.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 329.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.0, 520.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
284.0, 520.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
268.0, 533.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
285.0, 572.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.0, 580.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 628.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
420.98559775450417, 613.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
413.0, 629.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
422.0, 498.69069117598525

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
462.0, 508.08318322270355

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
597.0, 364.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
488.0, 501.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
591.0, 437.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.7365962981012, 462.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
574.0, 488.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
422.0, 520.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
615.0, 529.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
527.3548626638176, 579.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
375.0, 579.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.0, 671.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
582.0, 686.1159660434203

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
505.0, 325.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
638.7339445046937, 622.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
641.0, 653.0016561190512

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
672.0, 322.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
617.0, 304.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.4057970281387, 262.89723312160595

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
355.92587864891306, 358.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.0, 400.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
301.4950642846643, 343.61773353020016

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.29905858745315, 279.2747127716682

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.0, 282.2566142945288

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 397.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
403.0, 272.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.0, 333.85007049754176

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.0, 324.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
753.0, 331.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.0, 311.6981640364994

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
694.0, 252.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
725.0, 267.1649911683333

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1072.0, 838.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
994.0, 840.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1001.0, 900.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
580.0, 373.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
673.9864610658899, 901.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
578.8968438219807, 907.2805692684293

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1049.0, 966.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
995.0, 994.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.3548626638176, 1017.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.9614317307819, 1029.784604866222

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
568.5212577361842, 922.1833657818158

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.0598114124042, 363.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
354.22730431580266, 916.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
270.7976219786147, 913.5124930288467

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
540.0, 89.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
256.0, 866.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
469.4729753077728, 451.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
468.0, 909.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.6254145872576, 905.4193082425436

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
308.91523910000535, 641.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
313.0, 729.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.9977863862332, 708.1881832090878

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
370.9321961470599, 717.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
84.0, 973.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
101.53682105374172, 1004.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
503.0, 172.0

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
94.0, 1034.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
359.6984002102854, 451.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
178.0, 1077.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
366.0, 1088.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
510.0444191960745, 445.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
178.0, 985.172254584752

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
457.8646187432907, 990.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
564.2351924128152, 445.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
178.0, 1003.5084479102155

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
565.0, 1010.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.6636527173945, 245.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.89019008374987, 451.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
446.0, 986.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
178.0, 986.6848920724913

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
178.0, 1078.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
395.21645747403153, 451.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
402.0, 1114.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
178.0, 1057.4292315847556

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
525.7171015959672, 445.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
524.0, 1066.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
178.0, 943.1513543886333

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back