1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18031256.csml convertedTime:2009.07.01.11:10

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title An arms race: innate antiviral responses and counteracting viral strategies.
Authors Schroder M, Bowie AG.
Affiliation Viral Immune Evasion Group, School of Biochemistry and Immunology, TrinityCollege Dublin, Dublin 2, Ireland. schrodem@tcd.ie
Abstract Viral recognition is mediated by different classes of PRRs (pattern-recognitionreceptors) among which the TLRs (Toll-like receptors) and the RLHs [RIG(retinoic-acid-inducible)-like helicases] play major roles. The detection ofPAMPs (pathogen-associated molecular patterns) by these PRRs leads to theinitiation of signalling pathways that ultimately result in the activation oftranscription factors such as NF-kappaB (nuclear factor kappaB) and IRF-3 [IFN(interferon) regulatory factor-3] and IRF-7 and the induction ofpro-inflammatory cytokines and type I IFNs. Viruses have evolved a fine-tunedmechanism to evade detection by the immune system or to interfere with theresulting signalling pathways. Here, we discuss viral evasion proteins thatspecifically interfere with TLR and/or RLH signalling.
PMID 18031256
Model Abstract

Entity

G011345:IL10 MO000000022:p38 MO000000058:NF-kappaB MO000000212:TRAF6 MO000000213:IRAK MO000000215:IkappaB MO000007694:IRF-3 MO000007702:IRF-7 MO000008179:PKR(DAI)[ MO000016566:IRAK-2 MO000016573:MyD88 MO000016608:IKK-i MO000019331:TBK1 MO000019394:TLR4 MO000019395:TLRs MO000019398:TLR3 MO000022224:dsRNA MO000022225:dsRNA:PKR MO000041125:TRIF MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000066987:RIG-1 MO000094908:IPS-1 MO000103999:IFIH1(mda-5) e1: e10: e12: e13: e14: e15:ssRNA: TLR7 e16:ssRNA: TLR8 e17:CpGDNA: TLR9 e18:dsRNA: RIG-1 e19:dsRNA: mda-5 e2: e20:ssRNA: TLR7: MyD88 e21:ssRNA: TLR8: MyD88 e22:CpGDNA: TLR9: MyD88 e23:IRF-3 {activated} e24:dsRNA:TLR3: TRIF e25:IKK-alpha:IKK-beta:IKK-gamma e26:TLR ligand e27:TLR ligand: TLR e28:TLR ligand: TLR: MyD88 e29:TRAF6 {activated} e3: e30:IRAK [activated e31:IKK-alpha:IKK-beta:IKK-gamma {activated} e32:IkappaB {activated} e33:NF-kappaB {activated} e34:TLR4 ligand e35:TLR4 ligand: TLR4 e37:TLR4 ligand: TLR4: TRIF e38:IRF-7 {activated} e39:IKK-i {activated} e4: e40:TBK1 {activated} e41:IRF e42:IRF {activated} e43:dsDNA e44:dsDNA: DAI e45:dsDNA: DAI: TBK1 e46:v protein e47:NS1 e48:NS1: RIG-1 e49:v protein: mda-5 e5:CpGDNA e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:ssRNA e60: e61: e62: e64:VP35 e65:dsRNA: VP35 e66:NS3/4a e67:protein remnants e7: e70:A52 e71:A52: TRAF6 e72:A52: IRAK-2 e73:p38 {activated} e74:VAVC e75:A46 e76:N1 e77:K1 e78:M2 e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p56 p57 p6 p7 p8 p9
Model Detail
647.0, 1022.0
34.0, 34.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p45

--

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
753.0, 540.0
30.0, 30.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
937.0, 673.0
38.0, 38.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p57

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
857.0, 340.0
29.5, 29.5

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p42

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
928.0, 258.0
30.0, 30.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
935.0, 570.0
34.0, 34.0

IkappaB

--

MO000000215

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m186

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
940.0, 895.0
32.0, 32.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p35 p56

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
940.0, 803.0
32.0, 32.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
466.0, 329.0
28.0, 28.0

PKR(DAI)[

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p38

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
938.0, 345.0
28.0, 28.0

IRAK-2

--

MO000016566

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m1569

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
689.0, 371.0
35.0, 35.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8 p9 p12

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
684.0, 540.0
32.0, 32.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23 p25 p27 p28 p26

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
537.0, 769.0
29.0, 29.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p29 p19 p30 p31 p34

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
826.0, 205.0
27.0, 27.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
866.0, 201.0
28.0, 28.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
274.0, 469.0
27.5, 27.5

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
232.0, 82.0
30.0, 30.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p5 p6 p38 p39

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
512.0, 240.0
39.0, 39.0

dsRNA:PKR

--

MO000022225

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

--

true true true true

csml-variable:Double

m6524

10

false

infinite

0

unit false false false
TRANSPATHMO000022225

--

Go back
585.0, 371.0
28.0, 28.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p20 p40

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
315.0, 395.0
33.0, 33.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p10

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
282.0, 601.0
27.0, 27.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
279.0, 690.0
25.0, 25.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
274.0, 505.0
27.0, 27.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
294.0, 342.0
28.0, 28.0

RIG-1

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p37 p56 p57

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
465.0, 381.0
30.0, 30.0

IPS-1

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p56 p57

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
379.0, 263.0
33.0, 33.0

IFIH1(mda-5)

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p36

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
164.75, 180.9969080091176
893.6187113498208, 1297.5343688799387

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
173.0, 200.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
285.15813627140494, 403.2555325887016
253.65535812489293, 423.4754707678299

--

e12

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false true false

--

Go back
285.15813627140494, 403.2555325887016
253.65535812489293, 423.4754707678299

--

e13

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false true false

--

Go back
285.15813627140494, 403.2555325887016
253.65535812489296, 423.4754707678299

--

e14

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false true false

--

Go back
275.875, 536.5
32.25, 45.0

ssRNA: TLR7

--

e15

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p2

p7

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
284.875, 638.5
29.606395668930077, 41.311249770600114

ssRNA: TLR8

--

e16

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p3

p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
278.875, 733.5
25.684391631492016, 35.83868599743072

CpGDNA: TLR9

--

e17

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p4

p9

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
331.875, 296.5
29.811570930445953, 41.5975408331804

dsRNA: RIG-1

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
373.875, 304.5
27.854514589833, 38.866764543953025

dsRNA: mda-5

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
164.75, 180.9969080091176
893.6187113498208, 1297.5343688799387

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
519.5, 601.0
32.04679757753717, 44.71646173609836

ssRNA: TLR7: MyD88

--

e20

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p7

p27 p19

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
500.875, 693.5
30.766425032115986, 42.929895393650206

ssRNA: TLR8: MyD88

--

e21

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p8

p26 p30

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
431.875, 789.5
24.382317856487425, 34.02183886951734

CpGDNA: TLR9: MyD88

--

e22

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p9

p25 p31

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
948.0, 951.0
32.0, 32.0

IRF-3 {activated}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21 p35 p56

--

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
489.875, 478.5
29.140805652413288, 40.66158928243715

dsRNA:TLR3: TRIF

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p23 p24

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
935.0, 478.0
34.0, 34.0

IKK-alpha:IKK-beta:IKK-gamma

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
956.5, 114.375
38.884007029876976, 25.274604569420035

TLR ligand

--

e26

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p11

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
924.625, 184.5
29.989126812197966, 36.72137977003833

TLR ligand: TLR

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p12

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
993.875, 175.5
27.57042576619563, 38.47036153422646

TLR ligand: TLR: MyD88

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

p13

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
825.0, 392.0
29.5, 29.5

TRAF6 {activated}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

p15

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
182.62237422699644, 198.86928223611403
857.8739628958281, 1261.7896204259466

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
928.0, 298.0
30.0, 30.0

IRAK [activated

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

p14

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
931.0, 526.0
34.0, 34.0

IKK-alpha:IKK-beta:IKK-gamma {activated}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

p16

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
939.0, 610.0
34.0, 34.0

IkappaB {activated}

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

p17

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
945.0, 713.0
38.0, 38.0

NF-kappaB {activated}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p57

--

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
682.5, 115.375
34.66608084358523, 22.5329525483304

TLR4 ligand

--

e34

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p18

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
777.625, 189.5
29.180761539743376, 35.73154474254291

TLR4 ligand: TLR4

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

p20

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
683.875, 180.5
32.25, 45.0

TLR4 ligand: TLR4: TRIF

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p28 p29

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
940.0, 851.0
32.0, 32.0

IRF-7 {activated}

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22

--

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
720.0, 672.0
32.0, 32.0

IKK-i {activated}

--

e39

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23 p25 p27 p28 p26

p21 p22 p32

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
215.68626654693986, 230.1459371333576
791.7461782559415, 1199.2363106314588

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
716.0, 756.0
31.0, 31.0

TBK1 {activated}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24 p29 p19 p30 p31

p21 p22 p32

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
933.5, 1000.125
36.414771583819686, 22.455775810022136

IRF

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p32

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
934.5, 1032.125
34.857114107466295, 21.49522036627088

IRF {activated}

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

p32

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
265.5, 948.125
45.0, 15.75

dsDNA

--

e43

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
420.375, 901.5
23.25, 45.0

dsDNA: DAI

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
560.875, 902.5
30.01674619196183, 41.88383189576069

dsDNA: DAI: TBK1

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p35

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
378.5, 131.375
34.982425307557115, 22.738576449912127

v protein

--

e46

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p36

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
87.5, 288.375
39.165202108963086, 25.45738137082601

NS1

--

e47

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p37

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
245.625, 293.5
29.531869688385274, 36.16147308781869

NS1: RIG-1

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p5

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
436.625, 260.5
30.9199716713881, 37.861189801699716

v protein: mda-5

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

p6

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
111.0, 695.5
41.51447661469933, 14.530066815144764

CpGDNA

--

e5

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
432.71155653825224, 997.0
431.93851443663397, 391.7207756622737

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
479.3641335165105, 1006.2832129107619
252.56739950298538, 379.6554540299654

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
438.34203996666275, 1002.2283060406667
420.67754757981317, 381.2641635809396

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
439.14639474214994, 1003.0326608161541
419.06883802883857, 379.6554540299654

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
432.71155653825224, 997.0
431.93851443663397, 391.7207756622737

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
432.71155653825224, 997.0
431.93851443663397, 391.7207756622737

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
439.14639474214994, 1003.0326608161541
419.06883802883857, 379.6554540299654

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
748.0186285292398, 1157.8709550974431
26.985145094073662, 24.428657664108822

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
677.2354082863653, 1270.4806236656532
76.41370367128535, 69.17451069190051

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
432.71155653825224, 997.0
431.93851443663397, 391.7207756622737

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
100.0, 575.5
40.99808061420345, 22.548944337811896

ssRNA

--

e6

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p2 p3

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
534.5170340402311, 1171.0774758888983
13.678858085229104, 6.586116855851062

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
534.0602582496414, 1151.4361168935452
46.819518535434995, 84.27513336378301

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
553.7016172449951, 1206.2492117642987
7.3084126494337465, 7.308412649433755

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
270.5, 55.375
34.560632688927946, 22.464411247803163

VP35

--

e64

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p39

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
393.625, 52.5
27.44971671388102, 33.611898016997166

dsRNA: VP35

--

e65

cso30:c:Complex

cso30:i:CC_Extracellular

--

p39

p5 p38

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
591.125, 67.5
18.635892533708994, 30.22036627087945

NS3/4a

--

e66

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p40 p41

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
532.0, 367.0
24.0, 24.0

protein remnants

--

e67

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40 p41

--

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
176.0, 186.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1105.5, 494.375
37.58347978910369, 24.4292618629174

A52

--

e70

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p42 p43 p46 p49 p52

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
938.625, 430.5
26.90264122646225, 32.942009665055814

A52: TRAF6

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p44

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
895.625, 383.5
25.13076987168805, 30.772371271454755

A52: IRAK-2

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

p17

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
769.0, 600.0
30.0, 30.0

p38 {activated}

--

e73

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44

p45

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
1110.125, 1088.5
27.75, 45.0

VAVC

--

e74

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p47 p50 p53

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1114.125, 1220.5
27.75, 45.0

A46

--

e75

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p48 p51 p54

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
625.5, 1119.0
45.0, 24.0

N1

--

e76

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p46 p47 p48

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
625.5, 1191.0
45.0, 24.0

K1

--

e77

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p49 p50 p51

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
633.5, 1287.0
45.0, 24.0

M2

--

e78

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p52 p53 p54

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
179.0, 207.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
187.0, 228.0
823.3148129977221, 1185.186065010611

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
175.0, 430.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 18031256 TLR3 detects viral dsRNA (double-stranded RNA), e.g. purified genomic RNA from reovirus or the synthetic dsRNA analogue poly(I:C).

Go back
487.0, 430.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000041446

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m18998*m19314*0.1

nodelay

--

true

0

false

PMID: 18031256, 16006187 TLR3- and TLR4-induced IRF activation is mediated by TRIF, whereas MyD88 (myeloid differentiation factor 88) is sufficient for IRF activation induced by TLR7, 8 and 9.

Go back
867.0, 114.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e26 MO000019395

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m27*m3962*0.1

nodelay

--

true

0

false

PMID: 18031256 TLR signalling to NF-kappaB proceeds mainly via MyD88, the IRAKs [IL-1 (interleukin-1) receptor-associated kinases] and TRAF-6 (tumour-necrosis-factor-receptor-associated factor-6).

Go back
811.0, 262.0
25.0, 25.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000016573

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m28*m1572*0.1

nodelay

--

true

0

false

PMID: 18031256 TLR signalling to NF-kappaB proceeds mainly via MyD88, the IRAKs [IL-1 (interleukin-1) receptor-associated kinases] and TRAF-6 (tumour-necrosis-factor-receptor-associated factor-6).

Go back
866.0, 260.0
25.0, 25.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 MO000000213

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m29*m184*0.1

nodelay

--

true

0

false

PMID: 18031256 TLR signalling to NF-kappaB proceeds mainly via MyD88, the IRAKs [IL-1 (interleukin-1) receptor-associated kinases] and TRAF-6 (tumour-necrosis-factor-receptor-associated factor-6).

Go back
781.0, 312.0
29.0, 29.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000212 e30

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c42 : 1
stoichiometry:c39 : 1

m183*m31*0.1

nodelay

--

true

0

false

PMID: 18031256 TLR signalling to NF-kappaB proceeds mainly via MyD88, the IRAKs [IL-1 (interleukin-1) receptor-associated kinases] and TRAF-6 (tumour-necrosis-factor-receptor-associated factor-6).

Go back
874.0, 529.0
27.0, 27.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c45 : 1
stoichiometry:c44 : 1

m26*m30*0.1

nodelay

--

true

0

false

PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7.

Go back
874.0, 613.0
28.0, 28.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000215 e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1

m186*m32*0.1

nodelay

--

true

0

false

PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7.

Go back
873.0, 661.0
29.0, 29.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e32 e72

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c51 : 1
stoichiometry:c160 : 1
stoichiometry:c50 : 1

m25*m33*0.1

nodelay

--

true

0

false

PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7. PMID: 18031256 Through its interaction with IRAK2, it inhibits TLR-induced NF-kappaB activation and interferes with the induction of pro-inflammatory cytokines.

Go back
798.0, 113.0
27.0, 27.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e34 MO000019394

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m35*m3961*0.1

nodelay

--

true

0

false

Go back
632.0, 755.0
23.0, 23.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e20

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c93 : 1
stoichiometry:c88 : 1

m3902*m20*0.1

nodelay

--

true

0

false

PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7.

Go back
187.0, 546.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e6 MO000042126

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c8 : 1

m6*m19940*0.1

nodelay

--

true

0

false

PMID: 18031256 ssRNA (single-stranded RNA) (such as from influenza virus and HIV-1) is the ligand for TLR7/8.

Go back
724.0, 295.0
23.0, 23.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e35 MO000041125

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c59 : 1

m36*m18998*0.1

nodelay

--

true

0

false

PMID: 18031256, 16006187 TLR3- and TLR4-induced IRF activation is mediated by TRIF, whereas MyD88 (myeloid differentiation factor 88) is sufficient for IRF activation induced by TLR7, 8 and 9.

Go back
874.0, 881.0
27.0, 27.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e39 e40

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c62 : 1

m977*m40*m41*0.1

nodelay

--

true

0

false

PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7.

Go back
874.0, 805.0
27.0, 27.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007702 e40 e39

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c64 : 1

m980*m41*m40*0.1

nodelay

--

true

0

false

PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7.

Go back
624.0, 507.0
24.0, 24.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016608 e24

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c75 : 1
stoichiometry:c66 : 1

m1599*m24*0.1

nodelay

--

true

0

false

PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7.

Go back
628.0, 679.0
23.0, 23.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e24

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c76 : 1
stoichiometry:c68 : 1

m3902*m24*0.1

nodelay

--

true

0

false

PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7.

Go back
622.0, 625.0
27.0, 27.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e22 MO000016608

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c78 : 1
stoichiometry:c84 : 1

m22*m1599*0.1

nodelay

--

true

0

false

PMID: 18031256, 16006187 TLR3- and TLR4-induced IRF activation is mediated by TRIF, whereas MyD88 (myeloid differentiation factor 88) is sufficient for IRF activation induced by TLR7, 8 and 9. PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7.

Go back
623.0, 582.0
25.0, 25.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016608 e21

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c85 : 1
stoichiometry:c77 : 1

m1599*m21*0.1

nodelay

--

true

0

false

PMID: 18031256, 16006187 TLR3- and TLR4-induced IRF activation is mediated by TRIF, whereas MyD88 (myeloid differentiation factor 88) is sufficient for IRF activation induced by TLR7, 8 and 9. PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7.

Go back
623.0, 542.0
25.0, 25.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016608 e20

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c86 : 1
stoichiometry:c56 : 1

m1599*m20*0.1

nodelay

--

true

0

false

PMID: 18031256, 16006187 TLR3- and TLR4-induced IRF activation is mediated by TRIF, whereas MyD88 (myeloid differentiation factor 88) is sufficient for IRF activation induced by TLR7, 8 and 9. PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7.

Go back
687.0, 454.0
25.0, 25.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016608 e37

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c80 : 1
stoichiometry:c79 : 1

m1599*m38*0.1

nodelay

--

true

0

false

PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7.

Go back
631.0, 714.0
25.0, 25.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e37

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c83 : 1
stoichiometry:c82 : 1

m3902*m38*0.1

nodelay

--

true

0

false

PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7.

Go back
191.0, 602.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e6 MO000042007

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c9 : 1

m6*m19823*0.1

nodelay

--

true

0

false

PMID: 18031256 ssRNA (single-stranded RNA) (such as from influenza virus and HIV-1) is the ligand for TLR7/8.

Go back
630.0, 789.0
27.0, 27.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e21

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c94 : 1
stoichiometry:c90 : 1

m3902*m21*0.1

nodelay

--

true

0

false

PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7.

Go back
631.0, 822.0
25.0, 25.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e22

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c95 : 1
stoichiometry:c92 : 1

m3902*m22*0.1

nodelay

--

true

0

false

PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7.

Go back
877.0, 1028.0
30.0, 30.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e41 e39 e40

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c97 : 1

m42*m40*m41*0.1

nodelay

--

true

0

false

PMID: 18031256 Even though their upstream signalling pathways are distinct, it seems that the signalling pathways elicited by the different classes of PRRs converge at the level of the IKK [IkappaB (inhibitory kappaB) kinase] complex (containing IKK-alpha, -beta and -gamma) for activation of NF-kappaB and the related kinases IKK-epsilon and TBK1 (TANK-binding kinase-1) for activation of IRF-3 and IRF-7. PMID: 18031256, 16006187 TLR3- and TLR4-induced IRF activation is mediated by TRIF, whereas MyD88 (myeloid differentiation factor 88) is sufficient for IRF activation induced by TLR7, 8 and 9.

Go back
374.0, 942.0
27.0, 27.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e43 MO000008179

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c16 : 1
stoichiometry:c102 : 1

m44*m1055*0.1

nodelay

--

true

0

false

PMID: 18031256 It was demonstrated that DAI can respond to dsDNA (of mammalian, viral or bacterial origin) with the induction of an IFN response.

Go back
496.0, 911.0
23.0, 23.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019331 e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m3902*m45*0.1

nodelay

--

true

0

false

PMID: 18031256, 17618271 The newly discovered DNA receptor DAI also appears to engage TBK1 for activation of IRF-3.

Go back
878.0, 921.0
28.0, 28.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e45

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c108 : 1
stoichiometry:c107 : 1

m977*m46*0.1

nodelay

--

true

0

false

PMID: 18031256, 17618271 The newly discovered DNA receptor DAI also appears to engage TBK1 for activation of IRF-3.

Go back
340.0, 182.0
27.0, 27.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e46 MO000103999

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c169 : 1
stoichiometry:c113 : 1

m47*m76904*0.1

nodelay

--

true

0

false

PMID: 18031256 Recently, a couple of viral proteins have been described to prevent RNA detection through RIG-I and mda-5, e.g. the paramyxovirus V proteins, which bind to mda-5, and influenza virus NS1, which binds to RIG-I.

Go back
151.0, 289.0
23.0, 23.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e47 MO000066987

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m48*m41844*0.1

nodelay

--

true

0

false

PMID: 18031256 Recently, a couple of viral proteins have been described to prevent RNA detection through RIG-I and mda-5, e.g. the paramyxovirus V proteins, which bind to mda-5, and influenza virus NS1, which binds to RIG-I.

Go back
466.0, 85.0
27.0, 27.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000008179 e65

MO000022225

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c121 : 1
stoichiometry:c101 : 1

m119368*m1055*0.1

nodelay

--

true

0

false

PMID: 18031256 Other proteins such as Ebola virus VP35 bind to the dsRNA and thereby prevent detection by RIG-I and also PKR.

Go back
333.0, 56.0
25.0, 25.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e64 MO000022224

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m65*m119368*0.1

nodelay

--

true

0

false

PMID: 18031256 Other proteins such as Ebola virus VP35 bind to the dsRNA and thereby prevent detection by RIG-I and also PKR.

Go back
195.0, 690.0
25.0, 25.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000042012

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m5*m19828*0.1

nodelay

--

true

0

false

PMID: 18031256 Unmethylated viral CpG DNA [such as from HSV-2 (herpes simplex virus-2)] can stimulate TLR9.

Go back
611.0, 311.0
25.0, 25.0

p40

p40

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e66 MO000041125

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c129 : 1

m67*m18998*0.1

nodelay

--

true

0

false

PMID: 18031256, 17307033 Hepatitis C virus expresses the protease NS3/4a, which cleaves TRIF and the RLH (RIG-like helicase) adaptor IPS-1 and thereby specifically targets and evades TLR3- and TLR4- as well as RLH-signalling.

Go back
562.0, 309.0
27.0, 27.0

p41

p41

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e66 MO000094908

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c128 : 1
stoichiometry:c127 : 1

m67*m68199*0.1

nodelay

--

true

0

false

PMID: 18031256, 17307033 Hepatitis C virus expresses the protease NS3/4a, which cleaves TRIF and the RLH (RIG-like helicase) adaptor IPS-1 and thereby specifically targets and evades TLR3- and TLR4- as well as RLH-signalling. PMID: 18031256 Furthermore, from the finding that cleavage of IPS-1 by NS3/4a releases it from the mitochondrial membrane, we learned that the mitochondrial attachment of IPS-1 is functionally important.

Go back
861.0, 436.0
22.0, 22.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c136 : 1

m183*m71*0.1

nodelay

--

true

0

false

PMID: 18031256 A52 interacts with the downstream TLR signalling molecules TRAF-6 and IRAK2.

Go back
940.0, 387.0
23.0, 23.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016566 e70

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c133 : 1

m1569*m71*0.1

nodelay

--

true

0

false

PMID: 18031256 A52 interacts with the downstream TLR signalling molecules TRAF-6 and IRAK2.

Go back
826.0, 529.0
27.0, 27.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e71

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c139 : 1
stoichiometry:c138 : 1

m74*m72*0.1

nodelay

--

true

0

false

PMID: 18031256, 12566418, 15998638 On the other hand, its interaction with TRAF-6 mediates p38 MAPK (mitogen-activated protein kinase) activation and induction of the anti-inflammatory cytokine IL-10.

Go back
715.0, 1026.0
25.0, 25.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e73

G011345

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 18031256, 12566418, 15998638 On the other hand, its interaction with TRAF-6 mediates p38 MAPK (mitogen-activated protein kinase) activation and induction of the anti-inflammatory cytokine IL-10.

Go back
714.0, 1061.0
27.0, 27.0

p46

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e70

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c151 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 18031256, 15215253, 15016878, 15016878 Apart from A46 and A52, VACV encodes a whole range of immunomodulatory proteins, including several NF-kappaB inhibitors, such as N1 [9], K1 [10] and M2[11].

Go back
715.0, 1098.0
25.0, 25.0

p47

p47

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e74

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c152 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 18031256, 15215253, 15016878, 15016878 Apart from A46 and A52, VACV encodes a whole range of immunomodulatory proteins, including several NF-kappaB inhibitors, such as N1 [9], K1 [10] and M2[11].

Go back
714.0, 1133.0
27.0, 27.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e75

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c153 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 18031256, 15215253, 15016878, 15016878 Apart from A46 and A52, VACV encodes a whole range of immunomodulatory proteins, including several NF-kappaB inhibitors, such as N1 [9], K1 [10] and M2[11].

Go back
716.0, 1167.0
23.0, 23.0

p49

p49

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e70

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c154 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 18031256, 15215253, 15016878, 15016878 Apart from A46 and A52, VACV encodes a whole range of immunomodulatory proteins, including several NF-kappaB inhibitors, such as N1 [9], K1 [10] and M2[11].

Go back
261.0, 223.0
27.0, 27.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

MO000022224 MO000066987 e48 e65

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c115 : 1
stoichiometry:c120 : 1
stoichiometry:c17 : 1

m119368*m41844*0.1

nodelay

--

true

0

false

PMID: 18031256, 15208624 However, when two related DEXD/H-box RNA helicases RIG-I [RIG (retinoic-acid-inducible) protein I] and mda-5 (melanoma differentiation-associated gene-5) were described as novel cytoplasmic PRRs for viral dsRNA. PMID: 18031256 Recently, a couple of viral proteins have been described to prevent RNA detection through RIG-I and mda-5, e.g. the paramyxovirus V proteins, which bind to mda-5, and influenza virus NS1, which binds to RIG-I. PMID: 18031256 Other proteins such as Ebola virus VP35 bind to the dsRNA and thereby prevent detection by RIG-I and also PKR.

Go back
715.0, 1198.0
25.0, 25.0

p50

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e74

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c155 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 18031256, 15215253, 15016878, 15016878 Apart from A46 and A52, VACV encodes a whole range of immunomodulatory proteins, including several NF-kappaB inhibitors, such as N1 [9], K1 [10] and M2[11].

Go back
716.0, 1231.0
23.0, 23.0

p51

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e75

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c156 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 18031256, 15215253, 15016878, 15016878 Apart from A46 and A52, VACV encodes a whole range of immunomodulatory proteins, including several NF-kappaB inhibitors, such as N1 [9], K1 [10] and M2[11].

Go back
716.0, 1263.0
23.0, 23.0

p52

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e70

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c157 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 18031256, 15215253, 15016878, 15016878 Apart from A46 and A52, VACV encodes a whole range of immunomodulatory proteins, including several NF-kappaB inhibitors, such as N1 [9], K1 [10] and M2[11].

Go back
716.0, 1295.0
23.0, 23.0

p53

p53

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e74

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c158 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 18031256, 15215253, 15016878, 15016878 Apart from A46 and A52, VACV encodes a whole range of immunomodulatory proteins, including several NF-kappaB inhibitors, such as N1 [9], K1 [10] and M2[11].

Go back
717.0, 1324.0
21.0, 21.0

p54

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e75

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c159 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 18031256, 15215253, 15016878, 15016878 Apart from A46 and A52, VACV encodes a whole range of immunomodulatory proteins, including several NF-kappaB inhibitors, such as N1 [9], K1 [10] and M2[11].

Go back
883.0, 966.0
25.0, 25.0

p56

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 MO000066987 MO000094908

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c163 : 1
stoichiometry:c168 : 1
stoichiometry:c165 : 1

m977*m41844*m68199*0.1

nodelay

--

true

0

false

PMID: 18031256 The signalling pathway emanating from RIG-I is still less well defined, but it involves amitochondrial adaptor molecule called IPS-1 (IFNbeta promoter stimulator) [also called MAVS (mitochondrial antiviral signalling), Cardif [CARD (caspase recruitment domain) adaptor inducing IFN¦Â] orVISA (virusinduced signalling activator)] for activation of both NF-kappaB and IRF-3.

Go back
880.0, 752.0
24.0, 24.0

p57

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 MO000066987 MO000094908

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c167 : 1

m25*m41844*m68199*0.1

nodelay

--

true

0

false

PMID: 18031256 The signalling pathway emanating from RIG-I is still less well defined, but it involves amitochondrial adaptor molecule called IPS-1 (IFNbeta promoter stimulator) [also called MAVS (mitochondrial antiviral signalling), Cardif [CARD (caspase recruitment domain) adaptor inducing IFN¦Â] orVISA (virusinduced signalling activator)] for activation of both NF-kappaB and IRF-3.

Go back
305.0, 207.0
24.0, 24.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000022224 e49 MO000103999

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c116 : 1
stoichiometry:c170 : 1
stoichiometry:c18 : 1

m119368*m76904*0.1

nodelay

--

true

0

false

PMID: 18031256, 15208624 However, when two related DEXD/H-box RNA helicases RIG-I [RIG (retinoic-acid-inducible) protein I] and mda-5 (melanoma differentiation-associated gene-5) were described as novel cytoplasmic PRRs for viral dsRNA. PMID: 18031256 Recently, a couple of viral proteins have been described to prevent RNA detection through RIG-I and mda-5, e.g. the paramyxovirus V proteins, which bind to mda-5, and influenza virus NS1, which binds to RIG-I.

Go back
460.0, 547.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000016573

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m15*m1572*0.1

nodelay

--

true

0

false

PMID: 18031256, 16006187 TLR3- and TLR4-induced IRF activation is mediated by TRIF, whereas MyD88 (myeloid differentiation factor 88) is sufficient for IRF activation induced by TLR7, 8 and 9.

Go back
453.0, 648.0
21.0, 21.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e16 MO000016573

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c24 : 1
stoichiometry:c23 : 1

m16*m1572*0.1

nodelay

--

true

0

false

PMID: 18031256, 16006187 TLR3- and TLR4-induced IRF activation is mediated by TRIF, whereas MyD88 (myeloid differentiation factor 88) is sufficient for IRF activation induced by TLR7, 8 and 9.

Go back
457.0, 740.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_EndosomeMembrane

--

e17 MO000016573

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c27 : 1
stoichiometry:c26 : 1

m17*m1572*0.1

nodelay

--

true

0

false

PMID: 18031256, 16006187 TLR3- and TLR4-induced IRF activation is mediated by TRIF, whereas MyD88 (myeloid differentiation factor 88) is sufficient for IRF activation induced by TLR7, 8 and 9.

Go back
191.3393175972478, 112.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
153.0, 703.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
311.0, 956.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
484.0, 112.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
401.0, 936.7455923043988

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
514.4284133936338, 798.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.0, 923.1538177138508

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.0, 923.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
913.4724146788087, 917.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
906.0, 941.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
591.0, 924.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
127.0, 301.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.0, 703.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
181.4699689384164, 307.86348809305963

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
174.0, 302.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
367.0, 207.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
369.94257241545523, 154.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
264.0, 253.93547964039962

c115

c115

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
332.65524619448104, 225.6245538642138

c116

c116

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
262.0, 97.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
480.0, 120.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
220.0, 710.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
288.476346220865, 86.0

c120

c120

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
421.0, 75.0

c121

c121

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
305.0, 67.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
262.0, 75.16910522105907

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
358.0, 69.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.0, 98.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
605.0, 343.4278135270821

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.017084139092, 336.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
495.0, 338.84548267954216

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
562.5818427047461, 333.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
250.0, 112.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
577.8296258675465, 98.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
872.0, 370.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
890.7831980566987, 451.8498183722199

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
929.0, 399.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
952.0, 373.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
969.791979345758, 410.2271759564508

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
883.0, 447.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
783.0, 546.2854048166537

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
800.8915800086061, 556.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
859.0640869902634, 458.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
281.09783798089387, 257.72004376968937

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
731.0415635187981, 630.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
689.0, 1039.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.9999978515499, 519.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
746.999995224251, 517.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
748.0, 1111.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
747.7586667431851, 1115.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
748.7768216228604, 1151.8764448955963

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
747.0, 1243.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
745.7940801501668, 1246.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
746.1669707652475, 1118.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
256.0, 112.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.9999963927273, 507.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
671.5727049087313, 1085.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.7611400011626, 1114.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.830325002023, 1136.6389052329816

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.6857134627292, 1183.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.9488420383177, 1205.9032775043543

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.1234774575687, 1217.640888478313

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
686.5476811172091, 1279.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
686.9536563805268, 1301.8598547438407

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
686.1554175279994, 1313.5777087639997

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
391.1900298931486, 357.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
905.9782977400585, 399.0

c160

c160

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
322.0, 366.0

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
495.0, 409.0

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
31.662463652863437, 363.0

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
913.2570816034594, 927.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.0, 971.379042654018

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
908.2784093857208, 711.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
904.0, 744.2159204962816

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
56.03426235494578, 400.0

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
363.5777087639997, 216.15541752799933

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
287.0, 250.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
335.3080184481423, 232.92025438955102

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
325.0, 231.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
308.0, 559.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
207.4484561999481, 450.91898959187154

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.48211321000423, 402.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
483.0, 570.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
314.0, 659.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.0, 669.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
479.35443128577515, 406.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
305.0, 751.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
455.0588143418104, 761.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
479.4145266210127, 406.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
518.8930451015356, 393.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 415.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
200.0, 417.63435332442936

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.0, 455.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
900.0, 127.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
880.0, 147.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
889.0, 139.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
842.8053782967668, 213.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.0, 292.55792290769665

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
836.0, 204.20168164392288

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
897.8540648681575, 204.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
817.5230098060041, 334.7210886532355

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.0, 341.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
141.0, 566.6281649995302

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
899.0, 273.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
891.0, 281.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
817.958950698325, 314.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
907.4452081011954, 508.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 543.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
845.0, 422.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
908.7492919018569, 597.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
902.0, 627.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
902.6615021863596, 560.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
909.7988680525749, 680.7825984120171

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
219.2909647972694, 525.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
902.0, 686.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
908.4623275828736, 639.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
717.0, 127.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.3526867907002, 147.6462320697756

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
798.0130708141196, 140.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
655.9969153652218, 555.2221365379228

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.0, 567.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.8262546692157, 566.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.8936172657221, 225.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
710.6281649995302, 233.55597437364926

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
141.0, 594.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
613.0, 317.9488441556671

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.795129565557, 899.7988760535901

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 907.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
909.0, 819.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 828.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.9102312071875, 530.0309682041927

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
643.0, 531.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
566.0, 707.784883802265

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
651.0, 701.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.0, 704.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
224.0, 615.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
747.0, 784.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
747.0, 777.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.0, 702.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
700.0, 487.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.0, 739.1927794053147

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.0, 501.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
518.0, 519.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
648.0, 606.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.8949771993072, 572.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
702.0, 479.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
212.0, 559.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.0, 226.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
456.0, 656.2628957107687

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
656.0, 733.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.8637731252973, 226.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
649.0, 645.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.0, 612.6568542494924

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
552.0, 568.4805912281275

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
566.0, 770.4310835055999

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
655.0, 768.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
566.0, 787.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
216.0, 620.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
657.0, 780.5683142492632

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
566.0, 792.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.0, 787.660151531424

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.0, 643.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
532.0, 726.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
456.0, 809.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
914.1020362515915, 1021.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
907.0, 1043.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
743.0, 704.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
741.0, 787.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back