1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18161744.csml convertedTime:2009.07.01.14:54

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Macrophage activation by endogenous danger signals.
Authors Zhang X, Mosser DM.
Affiliation Department of Cell Biology and Molecular Genetics, University of Maryland,College Park, MD 20742, USA.
Abstract Macrophages are cells that function as a first line of defence against invadingmicroorganisms. One of the hallmarks of macrophages is their ability to becomeactivated in response to exogenous 'danger signals'. Most microbes havemolecular patterns (PAMPS) that are recognized by macrophages and trigger thisactivation response. There are many aspects of the activation response to PAMPSthat are recapitulated when macrophages encounter endogenous danger signals. Inresponse to damaged or stressed self, macrophages undergo physiological changesthat include the initiation of signal transduction cascades fromgermline-encoded receptors, resulting in the elaboration of chemokines,cytokines and toxic mediators. This response to endogenous mediators can enhanceinflammation, and thereby contribute to autoimmune pathologies. Often theoverall inflammatory response is the result of cooperative activation signalsfrom both exogenous and endogenous signals. Macrophage activation plays acritical role, not only in the initiation of the inflammatory response but alsoin the resolution of this response. The clearance of granulocytes and theelaboration of anti-inflammatory mediators by macrophages contribute to thedissolution of the inflammatory response. Thus, macrophages are a key player inthe initiation, propagation and resolution of inflammation. This reviewsummarizes our understanding of the role of macrophages in inflammation. We payparticular attention to the endogenous danger signals that macrophages mayencounter and the responses that these signals induce. The molecular mechanismsresponsible for these responses and the diseases that result frominappropriately controlled macrophage activation are also examined. 2007Pathological Society of Great Britain and Ireland
PMID 18161744
Model Abstract

Entity

G010228:IFN-beta G010279:MMP-9 G010329:TNF-alpha G010389:IL-1beta G010657:IL-12 p40 G010711:VEGF G011266:NOD1 G011270:NOD2 MO000000011:ERK MO000000058:NF-kappaB MO000000108:EGFR MO000000289:TNF-alpha MO000002553:CD44 MO000007694:IRF-3 MO000007702:IRF-7 MO000016573:MyD88 MO000016597:IL-1beta MO000016599:IKK-gamma:IKK-beta:IKK-alpha MO000016625:IL-18 MO000016632:p50:RelA-p65 MO000016882:LPS MO000017089:adenosine MO000017247:IL-10 MO000017265:IL-12 MO000017266:COX-2 MO000017549:fibronectin MO000017949:RIP2 MO000018229:proCaspase-1 MO000019397:TLR2 MO000019959:CCR6 MO000020119:Hsp60 MO000020434:Nod1 MO000020461:Nod2 MO000021614:Hsp70 MO000021732:glucocorticoids MO000038315:LPS:TLR4:MD-2 MO000038320:TLR4:MD-2 MO000038724:p50:RelA-p65:IkappaB-alpha MO000041125:TRIF MO000041445:TBK1:IKK-i MO000042012:TLR9 MO000042032:PGN MO000044014:ASC MO000044940:HMGB1 MO000066987:DDX58 MO000069310:RAGE MO000094908:MAVS MO000103999:IFIH1 e1: e10: e100:TLR4:MD-2:Fibronectin e101:Beta-defensins e102:Beta-defensins:CCR6 e103:Beta-defensin2 e104:Beta-defensin3 e105:Ox-LDL e106:CD36 e107:Chemokines e108:chemokines e109: e11:Lipid IVa e110: e111: e112:HMGB1 e113:HMGB1:TLR9 e114:TLR4:MD2:HMGB1 e115:TLR2:HMGB1 e116:HMGB1:RAGE e117:CpG ODNs e118:HMGB1:RAGE:CpG ODNs e119:HMGB1:RAGE:CpG ODNs:TLR9 e12:LPS:TLR4:MD-2:Lipid A e120:Lox1 e121:Ox-LDL:Lox1 e122:ATP e123:IL-18 e124:NALP3 e125:TLR ligands e126:NALP3 e127:Nigericin e128:NALP3:Nigericin e129:Maitotoxin e13:LPS:TLR4:MD-2:Lipid molecules:MyD88 e130:NALP3:Maitotoxin e131:S.aureus e132:NALP3:s.aureus e133:L.monocytogenes e134:NALP3:L.monocytogenes e135:Cardinal e136:NALP3:Maitotoxin:ASC:cardinal e137:Caspase-1 e138:Mrp8 e139:TLR4:MD-2:Mrp8 e14:LPS:TLR4:MD-2:Lipid A:TRIF e140:Mrp14 e141:TLR4:MD-2:Mrp14 e142:MyD88 e143:IRAK1 e144:IRAK1 e145:TNF e146:B7-H4 e147:Reg3g e148:Reg3g:PGN e149:eicosapentaenoic acid e15:LPS:TLR4:MD-2:Monophosphoryl Lipid A e150:Resolvins e151:ATPase-ADPase system e152:A2AR e153:A2AR:adenosine e154:A2BR e155:A2BR:adenosine e156:A2AR agonist e157:A2AR:adenosine:A2AR agonist e158:A2BR agonist e159:A2BR:adenosine:A2BR agonist e16:LPS:TLR4:MD-2:Monophosphoryl Lipid A:TRIF e160:IL-10 e161:VEGF e162:FPR1 e163:FPR1:Glucocorticoids e17:LPS:TLR4:MD-2: Lipid IVA e18:CARD4 e19:CARD15 e2: e20:Bacteria e21:Bacterial products e22:Nod2:Bacteria e23:Nod1:Bacterial products e24:Nod2 oligomer:bacteria e25:Nod1 oligomer:bacterial products e26:Nod2 oligomer:Bacteria:RIP2 e27:Nod1 oligomer:Bacterial products:RIP2 e28:IKK-gamma{ub}:IKK-beta:IKK-alpha e29:NF-kappaB{active} e3: e30:NF-kappaB{active} e31:GRIM19 e32:TLR2:PGN e33:3pRNA e34:DDX58:3pRNA e35:Poly I:C e36:IFIH1:Poly I:C e37:Viral RNA e38:OAS e39:OAS{active} e4: e40:ATP e41:2-5A e42:RNase L e43:RNase L{active} e44:Cellular RNA e45:small self RNA e46:IFIH1:small self RNA e47:DDX58:small self RNA e48:DDX58:3pRNA:MAVS e49:IFIH1:Poly I:C:MAVS e5:LIpid A e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Monophosphoryl Lipid A e60: e61: e62: e63:FADD:RIP-1:TRAF2:TRAF6 e64:FADD:RIP-1:TRAF2:TRAF6{active} e65:IKK-gamma:IKK-beta:IKK-alpha{active e66:degradants e67:p50:RelA-p65 e68:IFN-alpha e69:TRAF3:NAP1:TANK:NEMO e7: e70:IFIH1:Poly I:C:MAVS:TRAF3:NAP1:TANK:NEMO e71:DDX58:3pRNA:MAVS:TRAF3:NAP1:TANK:NEMO e72:TBK1:IKK-i{active} e73:IRF-3{active} e74:IRF-7{active} e75:IRF-3:IRF-3{active} e76:IRF-3:IRF-7{active} e77:IRF-7:IRF-7{active} e78:IRF-3:IRF-3{active} e79:IRF-3:IRF-7{active} e8: e80:IRF-3:IRF-7{active} e81:LPS:TLR4:MD-2:Hsp60 e82:NO e83:LPS:TLR4:MD-2:Hsp70 e84:Gp96 e85:LPS:TLR4:MD-2:Gp96 e86:TLR2:PGN:Gp96 e87:Pro-inflammatory cytokines e88:pro-inflammatory cytokines e89:Co-stimulation factors e9: e90:Co-stimulation factors e91:Hyaluronan e92:Hyaluronan:CD44 e93:Hyaluronan:TLR2 e94:TLR4:MD-2:Hyaluronan e95:Hyaluronic acid e96:Biglycan e97:DNA e98:HMGB1:DNA e99:Ox-LDL:CD36

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p114 p115 p116 p117 p118 p119 p12 p120 p121 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
694.0, 1550.0
28.0, 28.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p38 p52 p54 p56

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
835.0, 1311.0
26.0, 26.0

MMP-9

--

G010279

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p89

--

true true true true

csml-variable:Double

m93262

10

false

infinite

0

unit false false false
TRANSFACG010279

--

Go back
913.0, 1505.0
22.0, 22.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p59 p72 p73

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
855.0, 1523.0
26.0, 26.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p92 p102

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
810.0, 1630.0
28.0, 28.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
630.0, 1566.0
28.0, 28.0

VEGF

--

G010711

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p119 p120

true true true true

csml-variable:Double

m93629

10

false

infinite

0

unit false false false
TRANSFACG010711

--

Go back
914.0, 1378.0
27.0, 27.0

NOD1

--

G011266

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p8

p9

true true true true

csml-variable:Double

m94151

10

false

infinite

0

unit false false false
TRANSFACG011266

--

Go back
907.0, 1327.0
25.5, 25.5

NOD2

--

G011270

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p10

p11

true true true true

csml-variable:Double

m94155

10

false

infinite

0

unit false false false
TRANSFACG011270

--

Go back
639.0, 1755.0
26.0, 26.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p79

true true true true

csml-variable:Double

m107

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
601.0, 789.0
30.0, 30.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p21 p90 p108

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
585.0, 1761.0
22.0, 22.0

EGFR

--

MO000000108

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p78

true true true true

csml-variable:Double

m106

10

false

infinite

0

unit false false false
TRANSPATHMO000000108

--

Go back
1321.0, 1441.0
22.0, 22.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p59 p72 p73

p94

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
1241.0, 1165.0
22.0, 22.0

CD44

--

MO000002553

cso30:c:Protein

cso30:i:CC_CellComponent

--

p68

--

true true true true

csml-variable:Double

m399

10

false

infinite

0

unit false false false
InterProIPR001231
TRANSPATHMO000002553

--

Go back
746.0, 986.0
28.0, 28.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
844.0, 952.0
24.0, 24.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
896.0, 356.0
24.0, 24.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

p106

p3 p4 p107

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1319.0, 1559.0
26.0, 26.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p92 p102

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
785.0, 629.0
38.0, 38.0

IKK-gamma:IKK-beta:IKK-alpha

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p34

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
1339.0, 1391.0
26.0, 26.0

IL-18

--

MO000016625

cso30:c:Protein

cso30:i:CC_CellComponent

--

p93 p103

--

true true true true

csml-variable:Double

m1611

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000016625

--

Go back
388.0, 1196.0
32.0, 32.0

p50:RelA-p65

--

MO000016632

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

p36

true true true true

csml-variable:Double

m1617

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
403.0, 199.0
25.5, 25.5

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1382.0, 1782.0
20.0, 20.0

adenosine

--

MO000017089

cso30:c:Protein

cso30:i:CC_CellComponent

--

p113

p114 p115

true true true true

csml-variable:Double

m114924

10

false

infinite

0

unit false false false
TRANSPATHMO000017089

--

Go back
90.0, 1282.0
20.0, 20.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

p118

p110

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
1320.0, 1340.0
24.0, 24.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p61

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
998.0, 786.0
20.0, 20.0

COX-2

--

MO000017266

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p112

true true true true

csml-variable:Double

m2122

10

false

infinite

0

unit false false false
InterProIPR002016
TRANSPATHMO000017266

--

Go back
87.0, 511.0
18.0, 18.0

fibronectin

--

MO000017549

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p75 p89 p90

true true true true

csml-variable:Double

m2341

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000017549

--

Go back
817.0, 781.0
22.0, 22.0

RIP2

--

MO000017949

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p17

true true true true

csml-variable:Double

m2684

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017949

--

Go back
443.0, 1699.0
18.0, 18.0

proCaspase-1

--

MO000018229

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p101

true true true true

csml-variable:Double

m2906

10

false

infinite

0

unit false false false
InterProIPR001309
TRANSPATHMO000018229

--

Go back
1234.0, 566.0
20.0, 20.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p69 p72 p82 p85

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
171.0, 1367.0
26.0, 26.0

CCR6

--

MO000019959

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76

true true true true

csml-variable:Double

m4487

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000019959

--

Go back
926.0, 394.0
28.0, 28.0

Hsp60

--

MO000020119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m4645

10

false

infinite

0

unit false false false
InterProIPR002423
TRANSPATHMO000020119

--

Go back
1013.0, 941.0
21.5, 21.5

Nod1

--

MO000020434

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p13 p77

true true true true

csml-variable:Double

m4923

10

false

infinite

0

unit false false false
InterProIPR007091
TRANSPATHMO000020434

--

Go back
905.0, 937.0
22.0, 22.0

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

p12

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
1017.0, 357.0
22.0, 22.0

Hsp70

--

MO000021614

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m5956

10

false

infinite

0

unit false false false
InterProIPR001023
TRANSPATHMO000021614

--

Go back
1341.0, 893.0
22.0, 22.0

glucocorticoids

--

MO000021732

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p121

true true true true

csml-variable:Double

m6069

10

false

infinite

0

unit false false false
TRANSPATHMO000021732

--

Go back
500.0, 272.0
31.5, 31.5

LPS:TLR4:MD-2

--

MO000038315

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p2 p5 p7 p57 p60 p62 p92 p93

true true true true

csml-variable:Double

m16530

10

false

infinite

0

unit false false false
TRANSPATHMO000038315

--

Go back
407.0, 287.0
26.0, 26.0

TLR4:MD-2

--

MO000038320

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p70 p73 p75 p81 p84 p89 p104 p105

true true true true

csml-variable:Double

m16535

10

false

infinite

0

unit false false false
TRANSPATHMO000038320

--

Go back
460.0, 1160.0
32.0, 32.0

p50:RelA-p65:IkappaB-alpha

--

MO000038724

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m16910

10

false

infinite

0

unit false false false
TRANSPATHMO000038724

--

Go back
1154.0, 418.0
20.0, 20.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p6

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
749.0, 929.0
38.0, 38.0

TBK1:IKK-i

--

MO000041445

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m19313

10

false

infinite

0

unit false false false
TRANSPATHMO000041445

--

Go back
318.0, 1574.0
20.0, 20.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p83 p88

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
1307.0, 631.0
26.0, 26.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p111

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
710.0, 1766.0
20.0, 20.0

ASC

--

MO000044014

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p100

true true true true

csml-variable:Double

m21736

10

false

infinite

0

unit false false false
InterProIPR004020
TRANSPATHMO000044014

--

Go back
469.0, 1537.0
22.0, 22.0

HMGB1

--

MO000044940

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p74

true true true true

csml-variable:Double

m22603

10

false

infinite

0

unit false false false
TRANSPATHMO000044940

--

Go back
330.0, 466.0
19.0, 19.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23 p30

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
308.0, 1420.0
24.0, 24.0

RAGE

--

MO000069310

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86

true true true true

csml-variable:Double

m44154

10

false

infinite

0

unit false false false
TRANSPATHMO000069310

--

Go back
539.0, 687.0
26.0, 26.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31 p32

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
474.0, 414.0
20.0, 20.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p29

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
133.18381789875454, 247.4542407467527
1157.6901545172652, 1680.966104359069

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
135.1774521654616, 294.1981953282967
1128.6871057261505, 1587.745388358275

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
168.5, 554.0
31.431271792989545, 43.857588548357505

TLR4:MD-2:Fibronectin

--

e100

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p75

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
98.0, 1351.5
27.385791909841014, 16.887905011068625

Beta-defensins

--

e101

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p76

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
169.5, 1463.0
21.79039684279763, 42.17496163122122

Beta-defensins:CCR6

--

e102

cso30:c:Complex

cso30:i:CC_Cytosol

--

p76

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
537.0, 1466.0
37.57785467128028, 20.041522491349482

Beta-defensin2

--

e103

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p77

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
737.0, 1662.0
37.57785467128028, 20.041522491349482

Beta-defensin3

--

e104

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p78 p79

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
84.0, 1564.5
24.59649828939424, 15.167840611793117

Ox-LDL

--

e105

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p80 p91

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
168.5, 1562.0
23.052724077328648, 35.46572934973638

CD36

--

e106

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p80

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
806.0, 1246.0
52.83737024221453, 28.179930795847753

Chemokines

--

e107

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p81 p82

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
1320.0, 1299.5
23.040000000000006, 17.280000000000005

chemokines

--

e108

cso30:c:Protein

cso30:i:CC_Cytosol

--

p81 p82

--

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
273.0, 1568.0
110.1322890789446, 183.86492329281438

--

e109

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false true false

--

Go back
158.0, 331.0
44.78553406223717, 25.378469301934402

Lipid IVa

--

e11

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
273.0, 1568.0
110.1322890789446, 183.86492329281438

--

e110

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false true false

--

Go back
273.0, 1568.0
110.1322890789446, 183.86492329281438

--

e111

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false true false

--

Go back
237.0, 1201.0
22.0, 22.0

HMGB1

--

e112

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p83 p84 p85 p86

true true true true

csml-variable:Double

m115

10

false

infinite

0

unit false false false
TRANSPATHMO000044940

--

Go back
278.5, 1605.0
19.567857925893446, 37.87327340495506

HMGB1:TLR9

--

e113

cso30:c:Complex

cso30:i:CC_Cytosol

--

p83

--

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
168.5, 1100.0
23.437327950082583, 32.70324830244083

TLR4:MD2:HMGB1

--

e114

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p84

--

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
1237.5, 504.0
20.59416794562596, 39.85967989475992

TLR2:HMGB1

--

e115

cso30:c:Complex

cso30:i:CC_Cytosol

--

p85

--

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
247.5, 1357.0
24.724545909015163, 30.274954174304288

HMGB1:RAGE

--

e116

cso30:c:Complex

cso30:i:CC_Cytosol

--

p86

p87

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
270.0, 1121.5
60.0, 13.0

CpG ODNs

--

e117

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p87

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
348.5, 1252.0
22.963846577353646, 32.04257661956323

HMGB1:RAGE:CpG ODNs

--

e118

cso30:c:Complex

cso30:i:CC_Cytosol

--

p87

p88

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
363.0, 1642.0
17.382352941176475, 28.970588235294112

HMGB1:RAGE:CpG ODNs:TLR9

--

e119

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p88

--

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
814.0, 255.0
20.64705882352942, 34.41176470588236

LPS:TLR4:MD-2:Lipid A

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3 p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
168.5, 1739.0
22.093145869947275, 33.98945518453427

Lox1

--

e120

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p91

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false false false

--

Go back
170.5, 1805.0
19.221223415917564, 37.20236790177593

Ox-LDL:Lox1

--

e121

cso30:c:Complex

cso30:i:CC_Cytosol

--

p91

--

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
1317.0, 993.5
37.658349328214975, 20.712092130518233

ATP

--

e122

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p92 p93

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false false false

--

Go back
769.0, 1476.0
45.57093425605537, 24.304498269896193

IL-18

--

e123

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p93 p103

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
602.0, 1386.0
52.62975778546713, 28.069204152249135

NALP3

--

e124

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p94 p95

--

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
1311.0, 1707.5
26.057556852485405, 16.068826725699335

TLR ligands

--

e125

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p95 p120

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
947.5, 1690.0
17.528275306902803, 28.424230227409947

NALP3

--

e126

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p96 p97 p98 p99

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
997.0, 1683.5
22.56000000000001, 16.919999999999998

Nigericin

--

e127

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p96

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false false false

--

Go back
1149.5, 1691.0
21.295117480419936, 26.075654057657065

NALP3:Nigericin

--

e128

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p96

--

true true true true

csml-variable:Double

m131

0

false

infinite

0

unit false false false

--

Go back
888.0, 1723.0
15.05519176800748, 34.74275023386342

Maitotoxin

--

e129

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p97

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
1049.0, 289.0
22.676470588235297, 37.794117647058826

LPS:TLR4:MD-2:Lipid molecules:MyD88

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1075.5, 1785.0
24.52041326445592, 30.024995834027663

NALP3:Maitotoxin

--

e130

cso30:c:Complex

cso30:i:CC_Cytosol

--

p97

p100

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false false false

--

Go back
1160.5, 1779.0
23.842264722590414, 34.89111910622987

S.aureus

--

e131

cso30:c:Cell

cso30:i:CC_Cytosol

--

--

p98

true true true true

csml-variable:Double

m134

0

false

infinite

0

unit false false false

--

Go back
1172.5, 1734.0
22.552574570904852, 27.61539743376104

NALP3:s.aureus

--

e132

cso30:c:Complex

cso30:i:CC_Cytosol

--

p98

--

true true true true

csml-variable:Double

m135

0

false

infinite

0

unit false false false

--

Go back
1000.5, 1807.0
23.842264722590414, 34.89111910622987

L.monocytogenes

--

e133

cso30:c:Cell

cso30:i:CC_Cytosol

--

--

p99

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false false false

--

Go back
800.5, 1754.0
22.789368438593563, 27.90534910848192

NALP3:L.monocytogenes

--

e134

cso30:c:Complex

cso30:i:CC_Cytosol

--

p99

--

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false false false

--

Go back
853.0, 1815.0
14.301216089803555, 33.00280636108512

Cardinal

--

e135

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p100

true true true true

csml-variable:Double

m138

0

false

infinite

0

unit false false false

--

Go back
679.0, 1809.0
17.91176470588235, 29.852941176470587

NALP3:Maitotoxin:ASC:cardinal

--

e136

cso30:c:Complex

cso30:i:CC_Cytosol

--

p100

p101

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
394.0, 1774.0
28.0, 28.0

Caspase-1

--

e137

cso30:c:Protein

cso30:i:CC_CellComponent

--

p101

p102 p103

true true true true

csml-variable:Double

m140

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
1001.0, 560.5
21.12, 15.84

Mrp8

--

e138

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p104

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false false false

--

Go back
175.5, 695.0
24.289594420994675, 33.892457331620484

TLR4:MD-2:Mrp8

--

e139

cso30:c:Complex

cso30:i:CC_Cytosol

--

p104

p106

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false false false

--

Go back
1237.0, 309.0
22.676470588235297, 37.794117647058826

LPS:TLR4:MD-2:Lipid A:TRIF

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1048.0, 591.0
15.103835360149674, 34.855004677268475

Mrp14

--

e140

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p105

true true true true

csml-variable:Double

m143

0

false

infinite

0

unit false false false

--

Go back
171.5, 763.0
24.289594420994675, 33.892457331620484

TLR4:MD-2:Mrp14

--

e141

cso30:c:Complex

cso30:i:CC_Cytosol

--

p105

--

true true true true

csml-variable:Double

m144

0

false

infinite

0

unit false false false

--

Go back
304.0, 204.0
24.0, 24.0

MyD88

--

e142

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p106

true true true true

csml-variable:Double

m145

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1080.0, 422.5
24.799999999999997, 18.6

IRAK1

--

e143

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p107

true true true true

csml-variable:Double

m146

0

false

infinite

0

unit false false false

--

Go back
832.0, 682.5
24.799999999999997, 18.6

IRAK1

--

e144

cso30:c:Protein

cso30:i:CC_Cytosol

--

p107

p108

true true true true

csml-variable:Double

m147

0

false

infinite

0

unit false false false

--

Go back
515.0, 1421.0
41.003460207612456, 21.868512110726645

TNF

--

e145

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p109

--

true true true true

csml-variable:Double

m148

0

false

infinite

0

unit false false false

--

Go back
432.0, 1573.0
55.7439446366782, 29.730103806228374

B7-H4

--

e146

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p110

--

true true true true

csml-variable:Double

m149

0

false

infinite

0

unit false false false

--

Go back
1406.0, 641.5
27.360000000000003, 20.52

Reg3g

--

e147

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p111

true true true true

csml-variable:Double

m150

0

false

infinite

0

unit false false false

--

Go back
1406.5, 744.0
19.76003999333445, 24.195967338776878

Reg3g:PGN

--

e148

cso30:c:Complex

cso30:i:CC_Extracellular

--

p111

--

true true true true

csml-variable:Double

m151

0

false

infinite

0

unit false false false

--

Go back
1109.0, 823.0
45.79478553406224, 25.95037846930193

eicosapentaenoic acid

--

e149

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p112

true true true true

csml-variable:Double

m152

0

false

infinite

0

unit false false false

--

Go back
306.0, 275.0
20.64705882352942, 34.41176470588236

LPS:TLR4:MD-2:Monophosphoryl Lipid A

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p6

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1096.0, 886.0
15.176800748362954, 35.02338634237606

Resolvins

--

e150

cso30:c:Protein

cso30:i:CC_Cytosol

--

p112

--

true true true true

csml-variable:Double

m153

0

false

infinite

0

unit false false false

--

Go back
1448.0, 1852.5
23.03884081304086, 14.207285168041864

ATPase-ADPase system

--

e151

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p113

true true true true

csml-variable:Double

m154

0

false

infinite

0

unit false false false

--

Go back
1236.5, 1771.0
22.390158172231985, 34.44639718804921

A2AR

--

e152

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p114

true true true true

csml-variable:Double

m155

0

false

infinite

0

unit false false false

--

Go back
1242.5, 1833.0
19.51348388511291, 37.76803332602499

A2AR:adenosine

--

e153

cso30:c:Complex

cso30:i:CC_Extracellular

--

p114

p116

true true true true

csml-variable:Double

m156

0

false

infinite

0

unit false false false

--

Go back
1176.5, 1863.0
22.527240773286465, 34.6572934973638

A2BR

--

e154

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p115

true true true true

csml-variable:Double

m157

0

false

infinite

0

unit false false false

--

Go back
1072.5, 1863.0
22.01468976101732, 42.60907695680772

A2BR:adenosine

--

e155

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p115

p117

true true true true

csml-variable:Double

m158

0

false

infinite

0

unit false false false

--

Go back
1392.0, 1739.5
23.2, 17.4

A2AR agonist

--

e156

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p116

true true true true

csml-variable:Double

m159

0

false

infinite

0

unit false false false

--

Go back
1238.5, 1658.0
19.82308680491833, 27.660121123141856

A2AR:adenosine:A2AR agonist

--

e157

cso30:c:Complex

cso30:i:CC_Extracellular

--

p116

p59 p72 p73 p119

true true true true

csml-variable:Double

m160

0

false

infinite

0

unit false false false

--

Go back
1100.0, 1959.5
23.2, 17.4

A2BR agonist

--

e158

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p117

true true true true

csml-variable:Double

m161

0

false

infinite

0

unit false false false

--

Go back
966.5, 1870.0
19.82308680491833, 27.660121123141856

A2BR:adenosine:A2BR agonist

--

e159

cso30:c:Complex

cso30:i:CC_Extracellular

--

p117

p118

true true true true

csml-variable:Double

m162

0

false

infinite

0

unit false false false

--

Go back
1241.0, 369.0
22.676470588235297, 37.794117647058826

LPS:TLR4:MD-2:Monophosphoryl Lipid A:TRIF

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
484.0, 1627.0
47.2318339100346, 25.19031141868512

IL-10

--

e160

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p118

true true true true

csml-variable:Double

m163

0

false

infinite

0

unit false false false

--

Go back
429.0, 1956.0
14.276894293732461, 32.946679139382596

VEGF

--

e161

cso30:c:Protein

cso30:i:CC_Extracellular

--

p119 p120

--

true true true true

csml-variable:Double

m164

0

false

infinite

0

unit false false false

--

Go back
1231.5, 824.0
25.908611599297014, 39.85940246045695

FPR1

--

e162

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p121

true true true true

csml-variable:Double

m165

0

false

infinite

0

unit false false false

--

Go back
1233.5, 876.0
21.029160271870204, 40.701600526200394

FPR1:Glucocorticoids

--

e163

cso30:c:Complex

cso30:i:CC_Cytosol

--

p121

p64 p65

true true true true

csml-variable:Double

m166

0

false

infinite

0

unit false false false

--

Go back
174.0, 411.0
20.64705882352942, 34.41176470588236

LPS:TLR4:MD-2: Lipid IVA

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p3

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
874.0, 1461.5
60.0, 13.0

CARD4

--

e18

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p8

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
774.0, 1573.5
60.0, 13.0

CARD15

--

e19

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p10

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
133.18381789875454, 247.4542407467527
1157.6901545172652, 1680.966104359069

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1030.5, 696.0
27.669759515243324, 40.49233099791706

Bacteria

--

e20

cso30:c:Cell

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1027.0, 852.5
25.779834976856513, 15.897564902394851

Bacterial products

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
964.5, 722.0
22.528078653557735, 27.585402432927847

Nod2:Bacteria

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p14

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
944.5, 894.0
22.528078653557735, 27.585402432927847

Nod1:Bacterial products

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p15

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
719.0, 705.0
34.80662983425414, 38.674033149171265

Nod2 oligomer:bacteria

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p16

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
691.0, 841.0
34.80662983425414, 38.674033149171265

Nod1 oligomer:bacterial products

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p17

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
583.0, 733.0
34.209944751381215, 38.011049723756905

Nod2 oligomer:Bacteria:RIP2

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p18 p21

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
627.0, 877.0
34.209944751381215, 38.011049723756905

Nod1 oligomer:Bacterial products:RIP2

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
485.0, 629.0
38.0, 38.0

IKK-gamma{ub}:IKK-beta:IKK-alpha

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

p19

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
453.0, 841.0
30.0, 30.0

NF-kappaB{active}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19 p21 p90 p108

p20

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
156.33762098909983, 270.6080438370982
1111.3825483365754, 1634.6584981783808

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
497.0, 1281.0
30.0, 30.0

NF-kappaB{active}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

p109

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
351.5, 679.0
16.642181525457843, 26.98732139263433

GRIM19

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p21

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1234.5, 637.0
19.20762990572243, 37.176057882043416

TLR2:PGN

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p63

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
412.0, 367.0
48.63321799307958, 25.93771626297578

3pRNA

--

e33

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p23

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
425.5, 539.0
21.13997667055491, 25.885685719046833

DDX58:3pRNA

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p31

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
508.0, 363.0
47.28343145500421, 26.79394449116905

Poly I:C

--

e35

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p24

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
518.5, 508.0
26.333111148141978, 32.24462589568406

IFIH1:Poly I:C

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p32

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
800.0, 359.0
47.43944636678201, 25.301038062283734

Viral RNA

--

e37

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p25

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
966.0, 463.5
27.095995170054337, 16.70919702153351

OAS

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p25

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
946.0, 535.5
28.93137452203662, 17.841014288589257

OAS{active}

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

p25

p26

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
199.17215670623878, 311.1271992452023
1025.7134769022973, 1553.6201873621706

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
809.0, 465.5
37.658349328214975, 20.712092130518233

ATP

--

e40

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p26

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
778.5, 529.0
18.25799959750453, 29.6075669148722

2-5A

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

p26

p27

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
738.0, 405.0
12.781103835360149, 29.494855004677262

RNase L

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p27

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
682.0, 477.0
12.781103835360149, 29.494855004677262

RNase L{active}

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

p27

p28

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
726.0, 662.0
52.62975778546713, 28.069204152249135

Cellular RNA

--

e44

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p28

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
629.5, 540.0
29.637735849056607, 32.33207547169811

small self RNA

--

e45

cso30:c:RnaOther

cso30:i:CC_Cytosol

--

p28

p29 p30

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
680.5, 422.0
22.601566405599065, 27.675387435427425

IFIH1:small self RNA

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
360.5, 586.0
22.601566405599065, 27.675387435427425

DDX58:small self RNA

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
366.5, 750.0
19.475867131583783, 27.175628555698296

DDX58:3pRNA:MAVS

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

p33 p41

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
866.5, 602.0
19.475867131583783, 27.175628555698296

IFIH1:Poly I:C:MAVS

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p39 p40

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
586.0, 299.0
44.3313708999159, 25.121110176619013

LIpid A

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
380.46785297346406, 1177.1850937151355
623.4778560555513, 565.4259141509392

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
447.8081055828163, 1190.5848658805278
364.56619516097453, 548.0103315795546

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
388.5951248401099, 1184.731846162735
607.2233123222597, 550.3324092557394

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
389.7561636782022, 1185.892885000828
604.9012346460753, 548.0103315795546

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
380.46785297346406, 1177.1850937151355
623.4778560555513, 565.4259141509392

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
380.46785297346406, 1177.1850937151355
623.4778560555513, 565.4259141509392

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
389.7561636782022, 1185.892885000828
604.9012346460753, 548.0103315795546

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
835.5950775056347, 1409.3928613335918
38.95147074473077, 35.26133141101954

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
733.4236597535155, 1571.9382986665075
110.2986896187661, 99.84934007593586

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
380.46785297346406, 1177.1850937151355
623.4778560555513, 565.4259141509392

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
719.0, 284.0
42.918418839360804, 24.320437342304455

Monophosphoryl Lipid A

--

e6

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
527.4180755773283, 1428.4556978110204
19.74462759680101, 9.506672546607922

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
526.7587465730912, 1400.104550628852
67.58122293423901, 121.64620128163037

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
555.1098937552605, 1479.2240311372295
10.54926406778364, 10.549264067783659

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
326.0, 911.0
19.852941176470587, 33.088235294117645

FADD:RIP-1:TRAF2:TRAF6

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p33 p39

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
430.0, 963.0
19.852941176470587, 33.088235294117645

FADD:RIP-1:TRAF2:TRAF6{active}

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33 p39

p34

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
405.0, 1025.0
38.0, 38.0

IKK-gamma:IKK-beta:IKK-alpha{active

--

e65

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

p35

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
328.53360137851814, 1057.4824813325674
30.430786904078115, 29.416427340608852

degradants

--

e66

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p35

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
432.0, 1384.0
32.0, 32.0

p50:RelA-p65

--

e67

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

p37 p38

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
582.0, 1510.0
51.90311418685121, 27.681660899653977

IFN-alpha

--

e68

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p37 p51 p53 p55

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
957.0, 666.0
21.970588235294116, 36.61764705882353

TRAF3:NAP1:TANK:NEMO

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p40 p41

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
232.57232181199876, 262.7438662632855
1055.6567505140376, 1495.838347591848

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
878.0, 755.0
20.55882352941176, 34.26470588235294

IFIH1:Poly I:C:MAVS:TRAF3:NAP1:TANK:NEMO

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
522.0, 895.0
20.55882352941176, 34.26470588235294

DDX58:3pRNA:MAVS:TRAF3:NAP1:TANK:NEMO

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p42

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
577.0, 981.0
38.0, 38.0

TBK1:IKK-i{active}

--

e72

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

p43 p44

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
TRANSPATHMO000041445

--

Go back
590.0, 1034.0
28.0, 28.0

IRF-3{active}

--

e73

cso30:c:Protein

cso30:i:CC_CellComponent

--

p43

p45 p47

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
916.0, 984.0
24.0, 24.0

IRF-7{active}

--

e74

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44

p46 p47

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
570.5, 1108.0
19.711048158640224, 24.135977337110486

IRF-3:IRF-3{active}

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

p48

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
690.5, 1088.0
19.711048158640224, 24.135977337110486

IRF-3:IRF-7{active}

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

p49

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
810.5, 1088.0
19.711048158640224, 24.135977337110486

IRF-7:IRF-7{active}

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p50

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
562.5, 1264.0
19.711048158640224, 24.135977337110486

IRF-3:IRF-3{active}

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

p51 p52

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
634.5, 1232.0
19.711048158640224, 24.135977337110486

IRF-3:IRF-7{active}

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p49

p53 p54

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
236.3437648684094, 289.1439676581608
1012.7040997315445, 1470.4463528102058

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
718.5, 1220.0
19.711048158640224, 24.135977337110486

IRF-3:IRF-7{active}

--

e80

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p55 p56

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
1242.0, 435.0
20.55882352941176, 34.26470588235294

LPS:TLR4:MD-2:Hsp60

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p57

p58 p59

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
1124.0, 636.0
40.69806560134566, 23.062237174095873

NO

--

e82

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p58

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1242.0, 703.0
20.55882352941176, 34.26470588235294

LPS:TLR4:MD-2:Hsp70

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p60

p61

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
1142.0, 523.5
27.446166230629903, 16.925135842221774

Gp96

--

e84

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p62 p63

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1238.0, 763.0
20.55882352941176, 34.26470588235294

LPS:TLR4:MD-2:Gp96

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p62

p64 p67

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
1234.5, 925.0
26.68067535327583, 37.22884933015232

TLR2:PGN:Gp96

--

e86

cso30:c:Complex

cso30:i:CC_Extracellular

--

p63

p65 p66

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
904.0, 1414.0
39.34256055363322, 20.98269896193772

Pro-inflammatory cytokines

--

e87

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p64 p65

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1318.0, 1237.0
12.817586529466787, 29.579045837231057

pro-inflammatory cytokines

--

e88

cso30:c:Protein

cso30:i:CC_Extracellular

--

p64 p65

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
729.0, 1612.0
45.46712802768166, 24.249134948096888

Co-stimulation factors

--

e89

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p66 p67

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
246.40094635217156, 315.54406905303654
1008.0805500132412, 1451.1618173536153

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1327.5, 1622.0
17.461259810827126, 28.315556449989934

Co-stimulation factors

--

e90

cso30:c:Protein

cso30:i:CC_Extracellular

--

p66 p67

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
1377.0, 1083.5
21.60000000000001, 16.20000000000001

Hyaluronan

--

e91

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p68 p69 p70 p71

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
1241.5, 1108.0
20.26792370094277, 39.22823942117956

Hyaluronan:CD44

--

e92

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p68

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1237.5, 984.0
20.26792370094277, 39.22823942117956

Hyaluronan:TLR2

--

e93

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p69

--

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
1240.5, 1044.0
23.358414387961094, 32.59313635529455

TLR4:MD-2:Hyaluronan

--

e94

cso30:c:Complex

cso30:i:CC_Cytosol

--

p70

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1375.0, 1216.0
42.08578637510512, 23.848612279226238

Hyaluronic acid

--

e95

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p71

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1325.0, 1492.0
14.252572497661363, 32.89055191768007

Biglycan

--

e96

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p72 p73

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
547.0, 1541.5
57.882727513929424, 12.541257628018041

DNA

--

e97

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p74

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
582.0, 1639.5
60.0, 17.0

HMGB1:DNA

--

e98

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p74

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
178.5, 1654.0
18.10655557991668, 35.04494628370971

Ox-LDL:CD36

--

e99

cso30:c:Complex

cso30:i:CC_Cytosol

--

p80

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
505.0, 201.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000038320

MO000038315

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155666*m16535*0.1

nodelay

--

true

0

false

PMID: 18161744 Lipopolysaccharide (LPS), which binds to TLR4, is one of the most well-studied PAMPs. PMID: 18161744 TLR4 requires MD-2 to recognize the active moiety of LPS. PMID: 18161744 MD-2 is expressed as a dimer with TLR4 on the surface of immune cells.

Go back
822.0, 1422.0
19.0, 19.0

p8

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e19

G011270

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 18161744 NOD1 is encoded by the caspase-recruitment domain 4 (CARD4) gene, whereas NOD2 is encoded by the caspase-recruitment domain 15 (CARD15) gene.

Go back
770.0, 1814.0
19.0, 19.0

p100

p100

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e130 MO000044014 e135

e136

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c278 : 1
stoichiometry:c279 : 1
stoichiometry:c280 : 1
stoichiometry:c281 : 1

m133*m21736*m138*0.1

nodelay

--

true

0

false

PMID: 18161744 Upon interaction with its ligands, NALP3 recruits ASC via PYD?PYD interactions, and CARDINAL via NACHT?FIIND interactions, respectively.

Go back
507.0, 1795.0
17.0, 17.0

p101

p101

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e136 MO000018229

e137

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c282 : 1
stoichiometry:c283 : 1
stoichiometry:c284 : 1

m139*m2906*0.1

nodelay

--

true

0

false

PMID: 18161744 By interaction with ASC, NALP3 triggers the activation of caspase-1 and subsequent release of the proinflammatory cytokines IL-1beta and IL-18.

Go back
967.0, 1643.0
17.0, 17.0

p102

p102

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e137 G010389

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c285 : 1
stoichiometry:c286 : 1
stoichiometry:c287 : 1

m140*m93364*0.1

nodelay

--

true

0

false

PMID: 18161744 By interaction with ASC, NALP3 triggers the activation of caspase-1 and subsequent release of the proinflammatory cytokines IL-1beta and IL-18

Go back
1047.0, 1571.0
17.0, 17.0

p102

p103

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e123 e137

MO000016625

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c288 : 1
stoichiometry:c289 : 1
stoichiometry:c290 : 1

m126*m140*0.1

nodelay

--

true

0

false

PMID: 18161744 By interaction with ASC, NALP3 triggers the activation of caspase-1 and subsequent release of the proinflammatory cytokines IL-1beta and IL-18

Go back
830.0, 566.0
19.0, 19.0

p104

p104

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e138 MO000038320

e139

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c291 : 1
stoichiometry:c292 : 1
stoichiometry:c293 : 1

m141*m16535*0.1

nodelay

--

true

0

false

PMID: 18161744,17767165 Recently, Vogl et al demonstrated a pivotal role of these proteins in enhancing LPS-induced phagocyte activation via their interaction with TLR4 in models of LPSinduced shock and Escherichia coli-induced abdominal sepsis

Go back
746.0, 558.0
19.0, 19.0

p104

p105

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e140 MO000038320

e141

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c294 : 1
stoichiometry:c295 : 1
stoichiometry:c296 : 1

m143*m16535*0.1

nodelay

--

true

0

false

PMID: 18161744,17767165 Recently, Vogl et al demonstrated a pivotal role of these proteins in enhancing LPS-induced phagocyte activation via their interaction with TLR4 in models of LPSinduced shock and Escherichia coli-induced abdominal sepsis

Go back
277.0, 357.0
23.0, 23.0

p106

p106

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e142 e139

MO000016573

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c297 : 1
stoichiometry:c299 : 1
stoichiometry:c298 : 1

m145*m142*0.1

nodelay

--

true

0

false

PMID: 18161744 Mrp8 specifically interacts with the TLR4?MD2 complex to induce intracellular translocation of MyD88 and activation of IRAK-1 and NF-¦ÊB, leading to transcriptional up-regulation of TNF gene expression.

Go back
1017.0, 493.0
21.0, 21.0

p107

p107

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e143 MO000016573

e144

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c300 : 1
stoichiometry:c301 : 1
stoichiometry:c302 : 1

m146*m1572*0.1

nodelay

--

true

0

false

PMID: 18161744 Mrp8 specifically interacts with the TLR4?MD2 complex to induce intracellular translocation of MyD88 and activation of IRAK-1 and NF-¦ÊB, leading to transcriptional up-regulation of TNF gene expression.

Go back
261.0, 805.0
21.0, 21.0

p107

p108

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e144 MO000000058

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c303 : 1
stoichiometry:c304 : 1
stoichiometry:c305 : 1

m147*m29*0.1

nodelay

--

true

0

false

PMID: 18161744 Mrp8 specifically interacts with the TLR4?MD2 complex to induce intracellular translocation of MyD88 and activation of IRAK-1 and NF-¦ÊB, leading to transcriptional up-regulation of TNF gene expression.

Go back
491.0, 1363.0
19.0, 19.0

p109

p109

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

e145

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c306 : 1
stoichiometry:c307 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 18161744 Mrp8 specifically interacts with the TLR4?MD2 complex to induce intracellular translocation of MyD88 and activation of IRAK-1 and NF-¦ÊB, leading to transcriptional up-regulation of TNF gene expression.

Go back
988.0, 1028.0
23.0, 23.0

p9

p11

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011270

MO000020461

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c30 : 1

m94155*0.1

nodelay

--

true

0

false

PMID: 18161744 NOD1 is encoded by the caspase-recruitment domain 4 (CARD4) gene, whereas NOD2 is encoded by the caspase-recruitment domain 15 (CARD15) gene.

Go back
409.0, 1429.0
21.0, 21.0

p110

p110

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000017247

e146

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c308 : 1
stoichiometry:c309 : 1

m2103*0.1

nodelay

--

true

0

false

PMID: 18161744,16606666 IL-10 not only subverts the development of classical macrophage activation responses but also stimulates macrophages to express B7-H4, a novel member of the B7 family of T cell co-stimulator molecules

Go back
1358.0, 690.0
19.0, 19.0

p111

p111

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042032 e147

e148

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c310 : 1
stoichiometry:c311 : 1
stoichiometry:c312 : 1

m155701*m150*0.1

nodelay

--

true

0

false

PMID: 18161744 RegIIIgamma can bind to a carbohydrate component of PGN to kill the bacteria.

Go back
1077.0, 761.0
21.0, 21.0

p112

p112

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

MO000017266 e149

e150

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c313 : 1
stoichiometry:c314 : 1
stoichiometry:c315 : 1

m2122*m152*0.1

nodelay

--

true

0

false

PMID: 18161744 The metabolism of the C20 fatty acid eicosapentaenoic acid by COX2 can result in the formation of so-called resolvins, which were named because of their ability to contribute to the resolution of inflammation.

Go back
1449.0, 1781.0
21.0, 21.0

p113

p113

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

e151

MO000017089

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c317 : 1
stoichiometry:c316 : 1

m154*0.1

nodelay

--

true

0

false

PMID: 18161744 It can also be generated locally from extracellular ATP by the ectoenzymes ATPase?ADPase/5prime ?nucleotidase system expressed on leukocytes and endothelial cells

Go back
1310.0, 1742.0
19.0, 19.0

p114

p114

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e152 MO000017089

e153

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c318 : 1
stoichiometry:c319 : 1
stoichiometry:c320 : 1

m155*m114924*0.1

nodelay

--

true

0

false

PMID: 18161744,17321471,16339566 Treatment of macrophages with an agonist of the adenosine A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production by a post-translational mechanism

Go back
1230.0, 1942.0
19.0, 19.0

p114

p115

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e154 MO000017089

e155

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c321 : 1
stoichiometry:c322 : 1
stoichiometry:c323 : 1

m157*m114924*0.1

nodelay

--

true

0

false

PMID: 18161744,17321471,16339566 Treatment of macrophages with an agonist of the adenosine A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production by a post-translational mechanism

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1314.0, 1802.0
19.0, 19.0

p114

p116

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e153 e156

e157

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c324 : 1
stoichiometry:c325 : 1
stoichiometry:c326 : 1

m156*m159*0.1

nodelay

--

true

0

false

PMID: 18161744,17321471,16339566 Treatment of macrophages with an agonist of the adenosine A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production by a post-translational mechanism

Go back
1042.0, 1926.0
19.0, 19.0

p114

p117

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e155 e158

e159

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c330 : 1
stoichiometry:c331 : 1
stoichiometry:c332 : 1

m158*m161*0.1

nodelay

--

true

0

false

PMID: 18161744,17321471,16339566 Treatment of macrophages with an agonist of the adenosine A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production by a post-translational mechanism

Go back
336.0, 1480.0
23.0, 23.0

p118

p118

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e160 e159

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c333 : 1
stoichiometry:c335 : 1
stoichiometry:c334 : 1

m163*m162*0.1

nodelay

--

true

0

false

PMID: 18161744,17321471,16339566 Treatment of macrophages with an agonist of the adenosine A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production by a post-translational mechanism

Go back
492.0, 1708.0
23.0, 23.0

p119

p119

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010711 e157

e161

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c336 : 1
stoichiometry:c338 : 1
stoichiometry:c337 : 1

m93629*m160*0.1

nodelay

--

true

0

false

PMID: 18161744,17065555 Furthermore, the co-stimulation of macrophages with agonists of TLRs and A2AR results in an increase in VEGF production by macrophages

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904.0, 804.0
23.0, 23.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000020461 e20

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m4947*m20*0.1

nodelay

--

true

0

false

PMID: 18161744 Thus, NOD2 functions as a general sensor of most, if not all, bacteria, whereas NOD1 senses primarily products yielded from Gram-positive bacteria.

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532.0, 1760.0
23.0, 23.0

p119

p120

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010711 e125

e161

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c339 : 1
stoichiometry:c341 : 1
stoichiometry:c340 : 1

m93629*m128*0.1

nodelay

--

true

0

false

PMID: 18161744,17065555 Furthermore, the co-stimulation of macrophages with agonists of TLRs and A2AR results in an increase in VEGF production by macrophages

Go back
1303.0, 803.0
25.0, 25.0

p121

p121

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e162 MO000021732

e163

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c342 : 1
stoichiometry:c343 : 1
stoichiometry:c344 : 1

m165*m6069*0.1

nodelay

--

true

0

false

PMID: 18161744,12401407 These monocytes express high levels of formyl-peptide receptor 1 (FPR1), which, when ligated, suppresses the production of pro-inflammatory cytokines and removes damaged cells

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944.0, 828.0
23.0, 23.0

p12

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 MO000020434

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m21*m4923*0.1

nodelay

--

true

0

false

PMID: 18161744 Thus, NOD2 functions as a general sensor of most, if not all, bacteria, whereas NOD1 senses primarily products yielded from Gram-positive bacteria.

Go back
836.0, 712.0
23.0, 23.0

p14

p14

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e22

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 18161744 Upon oligomerization of NOD1 or NOD2, the recruitment of the serine/threonine kinase receptorinteracting serine/threonine kinase (RICK; also known as RIP2 or CARDIAK) occurs through a homophilic CARD?CARD interaction.

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808.0, 824.0
23.0, 23.0

p14

p15

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e23

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 18161744 Upon oligomerization of NOD1 or NOD2, the recruitment of the serine/threonine kinase receptorinteracting serine/threonine kinase (RICK; also known as RIP2 or CARDIAK) occurs through a homophilic CARD?CARD interaction.

Go back
697.0, 781.0
21.0, 21.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000017949

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m24*m2684*0.1

nodelay

--

true

0

false

PMID: 18161744 Upon oligomerization of NOD1 or NOD2, the recruitment of the serine/threonine kinase receptorinteracting serine/threonine kinase (RICK; also known as RIP2 or CARDIAK) occurs through a homophilic CARD?CARD interaction.

Go back
761.0, 893.0
21.0, 21.0

p16

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017949 e25

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m2684*m25*0.1

nodelay

--

true

0

false

PMID: 18161744 Upon oligomerization of NOD1 or NOD2, the recruitment of the serine/threonine kinase receptorinteracting serine/threonine kinase (RICK; also known as RIP2 or CARDIAK) occurs through a homophilic CARD?CARD interaction.

Go back
601.0, 637.0
21.0, 21.0

p18

p18

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e26 MO000016599

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m26*m1593*0.1

nodelay

--

true

0

false

PMID: 18161744,15620648 Instead, upon activation by NOD2, RICK induces K63-linked polyubiquitylation of IKKgamma /NEMO at a unique ubiquitylation site (Lysine-285)

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433.0, 693.0
21.0, 21.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 MO000000058

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m28*m29*0.1

nodelay

--

true

0

false

PMID: 18161744,14695475 It has been known that K63-linked polyubiquitylation is associated with activation of the NF-KappaB pathway

Go back
573.0, 221.0
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000038315 e5

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c8 : 1

m16530*m5*0.1

nodelay

--

true

0

false

PMID: 18161744 Lipid A and its two derivatives, monophosphoryl lipid A and lipid IVa, bind directly to MD-2.

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520.0, 1180.0
23.0, 23.0

p20

p20

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 18161744 The interaction of RICK and IKKgamma /NEMO leads to translocation of NF-KappaB transcription factors to the nucleus.

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481.0, 777.0
21.0, 21.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 e31 MO000000058

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m26*m32*m29*0.1

nodelay

--

true

0

false

PMID: 18161744,15692051 In addition to RICK, gene associated with retinoid-IFNinduced mortality 19 (GRIM19) is another intracellular molecule that has been associated with optimal NF-KappaB activation induced by NOD2 but not NOD1

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1310.0, 566.0
20.0, 20.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 MO000042032

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m3964*m155701*0.1

nodelay

--

true

0

false

PMID: 18161744 For example, PGN is a ligand for cell surface TLR2, but upon uptake by macrophages, PGN can be processed to yield MDP, a ligand for cytosolic NOD2.

Go back
425.0, 465.0
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m41844*m34*0.1

nodelay

--

true

0

false

PMID: 18161744,17038590,17038589 RIG-1, but not MDA5, can recognize uncapped 5prime2;- triphosphate RNA (termed 3pRNA) present in viruses that can only be generated by viral polymerases, while MDA5 is the principle cytoplasmic receptor for synthetic poly(I : C)

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545.0, 421.0
21.0, 21.0

p23

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000103999 e35

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m76904*m36*0.1

nodelay

--

true

0

false

PMID: 18161744,17038590,17038589 RIG-1, but not MDA5, can recognize uncapped 5prime2;- triphosphate RNA (termed 3pRNA) present in viruses that can only be generated by viral polymerases, while MDA5 is the principle cytoplasmic receptor for synthetic poly(I : C)

Go back
877.0, 481.0
21.0, 21.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e37 e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m38*m39*0.1

nodelay

--

true

0

false

PMID: 18161744 Viral RNAs also activate 2prime,5prime-oligoadenylate synthetase (OAS) to synthesize 2prime2;,5prime2;-linked oligoadenylate (2-5A) from ATP.

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852.0, 532.0
23.0, 23.0

p26

p26

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e39 e40

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m40*m41*0.1

nodelay

--

true

0

false

PMID: 18161744 Viral RNAs also activate 2prime,5prime-oligoadenylate synthetase (OAS) to synthesize 2prime2;,5prime2;-linked oligoadenylate (2-5A) from ATP.

Go back
733.0, 473.0
21.0, 21.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e41 e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m42*m43*0.1

nodelay

--

true

0

false

PMID:18161744 2-5A activates RNase L to cleavage cellular RNAs to yield small self-RNA molecules, which are also recognized by RIG-I and/or MDA5.

Go back
705.0, 545.0
21.0, 21.0

p28

p28

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e43 e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m44*m45*0.1

nodelay

--

true

0

false

MID:18161744 2-5A activates RNase L to cleavage cellular RNAs to yield small self-RNA molecules, which are also recognized by RIG-I and/or MDA5.

Go back
561.0, 493.0
21.0, 21.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000103999 e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m76904*m46*0.1

nodelay

--

true

0

false

MID:18161744 2-5A activates RNase L to cleavage cellular RNAs to yield small self-RNA molecules, which are also recognized by RIG-I and/or MDA5.

Go back
890.0, 298.0
19.0, 19.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000016573 e17

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c23 : 1
stoichiometry:c11 : 1

m12*m1572*0.1

nodelay

--

true

0

false

PMID: 18161744,17056597,17569869 Lipid A engagement results in activation of both MyD88-dependent and TRIF-dependent (MyD88-independent) signalling events, whereas monophosphoryl lipid A causes primarily activation of TRIF-mediated signalling pathways. PMID: 18161744,17569868 Binding of Lipid IVa to MD-2?TLR4 complex inhibits signalling events mediated by MyD88 and TRIF

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545.0, 589.0
21.0, 21.0

p29

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e45 MO000066987

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m46*m41844*0.1

nodelay

--

true

0

false

MID:18161744 2-5A activates RNase L to cleavage cellular RNAs to yield small self-RNA molecules, which are also recognized by RIG-I and/or MDA5.

Go back
426.0, 638.0
19.0, 19.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e34 MO000094908

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m35*m68199*0.1

nodelay

--

true

0

false

PMID: 18161744, 16713980 The adaptor protein for RIG-1 and MDA5 is named MAVS (VISA, CARDIF or IPS-1) PMID: 18161744 MAVS is recruited and bound to RIG-1 or MDA5 via CARD?CARD interactions.

Go back
598.0, 598.0
19.0, 19.0

p31

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 e36

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m68199*m37*0.1

nodelay

--

true

0

false

PMID: 18161744, 16713980 The adaptor protein for RIG-1 and MDA5 is named MAVS (VISA, CARDIF or IPS-1) PMID: 18161744 MAVS is recruited and bound to RIG-1 or MDA5 via CARD?CARD interactions.

Go back
302.0, 830.0
19.0, 19.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e48 e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m49*m64*0.1

nodelay

--

true

0

false

--

Go back
530.0, 934.0
19.0, 19.0

p33

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016599 e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m1593*m65*0.1

nodelay

--

true

0

false

--

Go back
386.0, 1114.0
19.0, 19.0

p35

p35

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

MO000038724 e65

MO000016632 e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c99 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m16910*m66*0.1

nodelay

--

true

0

false

PMID: 18161744 Figure 1

Go back
390.0, 1286.0
19.0, 19.0

p36

p36

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000016632

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m1617*0.1

nodelay

--

true

0

false

PMID: 18161744 Figure 1

Go back
501.0, 1497.0
21.0, 21.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 18161744 These events relay the signal through activation and translocation of NF-KappaB p65?p50 heterodimer and IRF3 as well as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.

Go back
801.0, 1369.0
21.0, 21.0

p37

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e67

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 18161744 These events relay the signal through activation and translocation of NF-KappaB p65?p50 heterodimer and IRF3 as well as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.

Go back
410.0, 782.0
19.0, 19.0

p33

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e49 e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m63*m64*0.1

nodelay

--

true

0

false

--

Go back
1154.0, 262.0
19.0, 19.0

p3

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000016573 MO000041125

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m12*m1572*m18998*0.1

nodelay

--

true

0

false

PMID: 18161744,17056597,17569869 Lipid A engagement results in activation of both MyD88-dependent and TRIF-dependent (MyD88-independent) signalling events, whereas monophosphoryl lipid A causes primarily activation of TRIF-mediated signalling pathways.

Go back
945.0, 597.0
22.0, 22.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m63*m70*0.1

nodelay

--

true

0

false

PMID: 18161744 TRAF3 has been shown to interact with MAVS, and be essential for MAVS-mediated IFNalpha production and antiviral responses.

Go back
649.0, 717.0
22.0, 22.0

p40

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 e69

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m49*m70*0.1

nodelay

--

true

0

false

PMID: 18161744 TRAF3 has been shown to interact with MAVS, and be essential for MAVS-mediated IFNalpha production and antiviral responses.

Go back
673.0, 937.0
21.0, 21.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e71 MO000041445

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m72*m19313*0.1

nodelay

--

true

0

false

PMID: 18161744 Figure 1

Go back
685.0, 989.0
21.0, 21.0

p42

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e72 MO000007694

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m73*m977*0.1

nodelay

--

true

0

false

PMID: 18161744 Figure 1

Go back
781.0, 1045.0
21.0, 21.0

p42

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e72 MO000007702

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m73*m980*0.1

nodelay

--

true

0

false

PMID: 18161744 Figure 1

Go back
469.0, 1029.0
21.0, 21.0

p45

p45

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e73

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c131 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 18161744 Figure 1

Go back
957.0, 1081.0
21.0, 21.0

p45

p46

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e74

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c133 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 18161744 Figure 1

Go back
682.0, 1038.0
19.0, 19.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e73 e74

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c132 : 1

m74*m75*0.1

nodelay

--

true

0

false

--

Go back
596.0, 1160.0
23.0, 23.0

p48

p48

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e75

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 18161744 Figure 1

Go back
632.0, 1120.0
23.0, 23.0

p48

p49

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e76

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 18161744 Figure 1

Go back
605.0, 365.0
21.0, 21.0

p2

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 MO000038315

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c16 : 1

m6*m16530*0.1

nodelay

--

true

0

false

PMID: 18161744 Lipid A and its two derivatives, monophosphoryl lipid A and lipid IVa, bind directly to MD-2.

Go back
740.0, 1136.0
23.0, 23.0

p48

p50

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e77

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c139 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 18161744 Figure 1

Go back
533.0, 1325.0
21.0, 21.0

p37

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e78

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 18161744 These events relay the signal through activation and translocation of NF-KappaB p65?p50 heterodimer and IRF3 as well as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.

Go back
609.0, 1325.0
21.0, 21.0

p37

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e78

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 18161744 These events relay the signal through activation and translocation of NF-KappaB p65?p50 heterodimer and IRF3 as well as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.

Go back
637.0, 1293.0
21.0, 21.0

p37

p53

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e79

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m80*0.1

nodelay

--

true

0

false

PMID: 18161744 These events relay the signal through activation and translocation of NF-KappaB p65?p50 heterodimer and IRF3 as well as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.

Go back
693.0, 1309.0
21.0, 21.0

p37

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e79

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m80*0.1

nodelay

--

true

0

false

PMID: 18161744 These events relay the signal through activation and translocation of NF-KappaB p65?p50 heterodimer and IRF3 as well as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.

Go back
733.0, 1301.0
21.0, 21.0

p37

p55

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e80

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m81*0.1

nodelay

--

true

0

false

PMID: 18161744 These events relay the signal through activation and translocation of NF-KappaB p65?p50 heterodimer and IRF3 as well as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.

Go back
777.0, 1325.0
21.0, 21.0

p37

p56

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e80

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m81*0.1

nodelay

--

true

0

false

PMID: 18161744 These events relay the signal through activation and translocation of NF-KappaB p65?p50 heterodimer and IRF3 as well as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.

Go back
766.0, 430.0
19.0, 19.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000038315 MO000020119

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m16530*m4645*0.1

nodelay

--

true

0

false

PMID: 18161744,10623794 In macrophages, HSP60 induces the production of NO and TNFalpha via TLR4

Go back
1145.0, 557.0
21.0, 21.0

p58

p58

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e81

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1

m82*0.1

nodelay

--

true

0

false

--

Go back
1088.0, 1512.0
23.0, 23.0

p59

p59

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e81 e157

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c159 : 1
stoichiometry:c327 : 1
stoichiometry:c158 : 1

m93309*m82*0.1

nodelay

--

true

0

false

PMID: 18161744,10623794 In macrophages, HSP60 induces the production of NO and TNFalpha via TLR4 PMID: 18161744,17321471,16339566 Treatment of macrophages with an agonist of the adenosine A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production by a post-translational mechanism

Go back
978.0, 210.0
19.0, 19.0

p3

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000041125

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m15*m18998*0.1

nodelay

--

true

0

false

PMID: 18161744,17056597,17569869 Lipid A engagement results in activation of both MyD88-dependent and TRIF-dependent (MyD88-independent) signalling events, whereas monophosphoryl lipid A causes primarily activation of TRIF-mediated signalling pathways.

Go back
1017.0, 429.0
22.0, 22.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000038315 MO000021614

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m16530*m5956*0.1

nodelay

--

true

0

false

PMID: 18161744,11842086 TLR4 is also critical for HSP70 induction of IL-12 production

Go back
1026.0, 1394.0
19.0, 19.0

p61

p61

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e83 G010657

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c164 : 1
stoichiometry:c165 : 1

m84*m93589*0.1

nodelay

--

true

0

false

--

Go back
1026.0, 522.0
19.0, 19.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000038315 e84

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c168 : 1

m16530*m85*0.1

nodelay

--

true

0

false

PMID: 18161744,11912201 Gp96- induced production of pro-inflammatory cytokines and other co-stimulation factors from bone marrowderived DCs is also dependent on TLR4 but it may also involve TLR2

Go back
1078.0, 678.0
19.0, 19.0

p62

p63

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e84 e32

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1

m85*m33*0.1

nodelay

--

true

0

false

PMID: 18161744,11912201 Gp96- induced production of pro-inflammatory cytokines and other co-stimulation factors from bone marrowderived DCs is also dependent on TLR4 but it may also involve TLR2

Go back
1009.0, 1313.0
21.0, 21.0

p64

p64

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e87 e85 e163

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c174 : 1
stoichiometry:c345 : 1
stoichiometry:c173 : 1

m88*m86*0.1

nodelay

--

true

0

false

PMID: 18161744,11912201 Gp96- induced production of pro-inflammatory cytokines and other co-stimulation factors from bone marrowderived DCs is also dependent on TLR4 but it may also involve TLR2 PMID: 18161744,12401407 These monocytes express high levels of formyl-peptide receptor 1 (FPR1), which, when ligated, suppresses the production of pro-inflammatory cytokines and removes damaged cells

Go back
985.0, 1109.0
21.0, 21.0

p64

p65

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e86 e87 e163

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c346 : 1
stoichiometry:c177 : 1

m87*m88*0.1

nodelay

--

true

0

false

PMID: 18161744,11912201 Gp96- induced production of pro-inflammatory cytokines and other co-stimulation factors from bone marrowderived DCs is also dependent on TLR4 but it may also involve TLR2 PMID: 18161744,12401407 These monocytes express high levels of formyl-peptide receptor 1 (FPR1), which, when ligated, suppresses the production of pro-inflammatory cytokines and removes damaged cells

Go back
1065.0, 1625.0
21.0, 21.0

p64

p66

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e89 e86

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c180 : 1
stoichiometry:c179 : 1

m90*m87*0.1

nodelay

--

true

0

false

PMID: 18161744,11912201 Gp96- induced production of pro-inflammatory cytokines and other co-stimulation factors from bone marrowderived DCs is also dependent on TLR4 but it may also involve TLR2

Go back
1009.0, 1581.0
21.0, 21.0

p64

p67

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e89 e85

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c183 : 1
stoichiometry:c182 : 1

m90*m86*0.1

nodelay

--

true

0

false

PMID: 18161744,11912201 Gp96- induced production of pro-inflammatory cytokines and other co-stimulation factors from bone marrowderived DCs is also dependent on TLR4 but it may also involve TLR2

Go back
1316.0, 1148.0
23.0, 23.0

p68

p68

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e91

MO000002553 e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c185 : 1
stoichiometry:c186 : 1

m92*0.1

nodelay

--

true

0

false

PMID: 18161744 CD44 is the major cell surface receptor for hyaluronan, but recent evidence indicates that hyaluronan can also bind to and signal through TLR2 and TLR4.

Go back
1356.0, 800.0
23.0, 23.0

p68

p69

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e91 MO000019397

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m92*m3964*0.1

nodelay

--

true

0

false

PMID: 18161744 CD44 is the major cell surface receptor for hyaluronan, but recent evidence indicates that hyaluronan can also bind to and signal through TLR2 and TLR4.

Go back
337.0, 373.0
21.0, 21.0

p2

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000038315 e11

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m16530*m11*0.1

nodelay

--

true

0

false

PMID: 18161744 Lipid A and its two derivatives, monophosphoryl lipid A and lipid IVa, bind directly to MD-2.

Go back
1376.0, 548.0
23.0, 23.0

p68

p70

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e91 MO000038320

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1

m92*m16535*0.1

nodelay

--

true

0

false

PMID: 18161744 CD44 is the major cell surface receptor for hyaluronan, but recent evidence indicates that hyaluronan can also bind to and signal through TLR2 and TLR4.

Go back
1385.0, 1153.0
19.0, 19.0

p71

p71

cso30:i:ME_Cleavage

cso30:i:CC_Extracellular

--

e91

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c194 : 1

m92*0.1

nodelay

--

true

0

false

PMID: 18161744 During tissue injury and/or inflammation, however, hyaluronan is progressively cleaved by a series of enzymatic reactions that yield hyaluronic acids of smaller sizes.

Go back
1143.0, 1423.0
17.0, 17.0

p72

p72

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 MO000019397 e96 e157

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c197 : 1
stoichiometry:c199 : 1
stoichiometry:c329 : 1
stoichiometry:c196 : 1

m93309*m3964*m97*0.1

nodelay

--

true

0

false

PMID: 18161744,16025156 Biglycan acts on macrophages to produce TNFalpha and MIP-2 in a TLR2- and TLR4- dependent manner PMID: 18161744,17321471,16339566 Treatment of macrophages with an agonist of the adenosine A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production by a post-translational mechanism

Go back
1127.0, 1463.0
17.0, 17.0

p72

p73

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e96 MO000038320 e157

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c200 : 1
stoichiometry:c202 : 1
stoichiometry:c328 : 1
stoichiometry:c201 : 1

m93309*m97*m16535*0.1

nodelay

--

true

0

false

PMID: 18161744,16025156 Biglycan acts on macrophages to produce TNFalpha and MIP-2 in a TLR2- and TLR4- dependent manner PMID: 18161744,17321471,16339566 Treatment of macrophages with an agonist of the adenosine A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production by a post-translational mechanism

Go back
517.0, 1585.0
21.0, 21.0

p74

p74

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

MO000044940 e97 e98

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m22603*m98*m99*0.1

nodelay

--

true

0

false

PMID: 18161744 These proteins bind to the minor groove of DNA with little sequence specificity and regulate many transcriptional events, primarily by increasing the binding affinity of transcription factors to their corresponding DNA binding sites via bending or distortion of the double helix.

Go back
280.0, 496.0
23.0, 23.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000038320 MO000017549

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c244 : 1
stoichiometry:c208 : 1

m16535*m2341*0.1

nodelay

--

true

0

false

PMID: 18161744,16267105 In fact FNEDA, as an endogenous ligand for TLR4, has been investigated as a potential adjuvant

Go back
99.0, 1423.0
25.0, 25.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e101 MO000019959

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c210 : 1
stoichiometry:c211 : 1

m102*m4487*0.1

nodelay

--

true

0

false

PMID: 18161744,10521347 Beta-Defensins interact with CCR6 on the cell surface of both dendritic and T cells to bridge innate and adaptive immunity

Go back
437.0, 1473.0
21.0, 21.0

p77

p77

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000020434

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c213 : 1

m4923*0.1

nodelay

--

true

0

false

PMID: 18161744,16513653 For example, human Beta-defensin 2 expression is dependent on NOD1, whereas Beta-defensin 3 expression is NOD1-independent but dependent on EGFR and the ERK pathway

Go back
641.0, 1617.0
21.0, 21.0

p77

p78

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000108

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c215 : 1

m106*0.1

nodelay

--

true

0

false

PMID: 18161744,16513653 For example, human Beta-defensin 2 expression is dependent on NOD1, whereas Beta-defensin 3 expression is NOD1-independent but dependent on EGFR and the ERK pathway

Go back
645.0, 1673.0
21.0, 21.0

p77

p79

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000011

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c216 : 1

m107*0.1

nodelay

--

true

0

false

PMID: 18161744,16513653 For example, human Beta-defensin 2 expression is dependent on NOD1, whereas Beta-defensin 3 expression is NOD1-independent but dependent on EGFR and the ERK pathway

Go back
842.0, 1354.0
19.0, 19.0

p8

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e18

G011266

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 18161744 NOD1 is encoded by the caspase-recruitment domain 4 (CARD4) gene, whereas NOD2 is encoded by the caspase-recruitment domain 15 (CARD15) gene.

Go back
54.0, 1622.0
19.0, 19.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e105 e106

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1
stoichiometry:c250 : 1

m108*m109*0.1

nodelay

--

true

0

false

PMID: 18161744,16473764 The receptors for Ox-LDL are in the scavenger receptor family, and include CD36 and a newly described family member termed lectinlike oxidized lipoprotein scavenger receptor (LOX- 1)

Go back
997.0, 1165.0
21.0, 21.0

p81

p81

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e107 MO000038320

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c222 : 1
stoichiometry:c221 : 1

m110*m16535*0.1

nodelay

--

true

0

false

PMID: 18161744,16244651 Hyaluronan fragments isolated from individuals with acute lung injuries can activate macrophages to produce chemokines in a TLR2- and TLR4-dependent fashion

Go back
889.0, 1157.0
21.0, 21.0

p81

p82

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e107 MO000019397

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c223 : 1
stoichiometry:c225 : 1
stoichiometry:c224 : 1

m110*m3964*0.1

nodelay

--

true

0

false

PMID: 18161744,16244651 Hyaluronan fragments isolated from individuals with acute lung injuries can activate macrophages to produce chemokines in a TLR2- and TLR4-dependent fashion

Go back
278.0, 1454.0
19.0, 19.0

p83

p83

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e112 MO000042012

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c227 : 1
stoichiometry:c228 : 1

m115*m19828*0.1

nodelay

--

true

0

false

PMID: 18161744,16267105 HMGB1 may either signal through multiple receptors or associate with multiple ligands to signal through different receptors. TLR4, TLR2 and TLR9 have all been reported to respond to HMGB1

Go back
238.0, 1058.0
19.0, 19.0

p83

p84

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e112 MO000038320

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c229 : 1
stoichiometry:c230 : 1
stoichiometry:c231 : 1

m115*m16535*0.1

nodelay

--

true

0

false

PMID: 18161744,16267105 HMGB1 may either signal through multiple receptors or associate with multiple ligands to signal through different receptors. TLR4, TLR2 and TLR9 have all been reported to respond to HMGB1

Go back
1014.0, 650.0
19.0, 19.0

p83

p85

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e112 MO000019397

e115

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c232 : 1
stoichiometry:c233 : 1
stoichiometry:c234 : 1

m115*m3964*0.1

nodelay

--

true

0

false

PMID: 18161744,16267105 HMGB1 may either signal through multiple receptors or associate with multiple ligands to signal through different receptors. TLR4, TLR2 and TLR9 have all been reported to respond to HMGB1

Go back
314.0, 1354.0
19.0, 19.0

p86

p86

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e112 MO000069310

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c236 : 1
stoichiometry:c237 : 1

m115*m44154*0.1

nodelay

--

true

0

false

PMID: 18161744,15978523 The immunoglobulin ¡Æsuperfamily¡Ç member RAGE has also been reported to be a receptor for HMGB1

Go back
290.0, 1206.0
19.0, 19.0

p87

p87

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e117 e116

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c239 : 1
stoichiometry:c240 : 1

m120*m119*0.1

nodelay

--

true

0

false

PMID: 18161744 Recently, Coyle and colleagues showed that class A CpG-containing oligodeoxynucleotides (ODNs) and HMGB1 can form a complex.

Go back
345.0, 1337.0
21.0, 21.0

p88

p88

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e118 MO000042012

e119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c242 : 1
stoichiometry:c243 : 1

m121*m19828*0.1

nodelay

--

true

0

false

PMID: 18161744 The resultant complex induced association of TLR9 and RAGE to activate plasmacytoid DCs to produce IFNalpha

Go back
773.0, 1257.0
21.0, 21.0

p89

p89

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000017549 MO000038320

G010279

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c246 : 1
stoichiometry:c207 : 1

m2341*m16535*0.1

nodelay

--

true

0

false

PMID: 18161744 Recombinant Fn-EDA, but not other domains of fibronectin, was demonstrated to induce MMP-9 expression from human macrophages via TLR4.

Go back
1012.0, 1232.0
23.0, 23.0

p9

p9

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011266

MO000020434

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m94151*0.1

nodelay

--

true

0

false

PMID: 18161744 NOD1 is encoded by the caspase-recruitment domain 4 (CARD4) gene, whereas NOD2 is encoded by the caspase-recruitment domain 15 (CARD15) gene.

Go back
258.0, 650.0
19.0, 19.0

p90

p90

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017549 MO000000058

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c248 : 1
stoichiometry:c249 : 1

m2341*m29*0.1

nodelay

--

true

0

false

PMID: 18161744 Fn- EDA also activates NF-KappaB in macrophages.

Go back
86.0, 1742.0
19.0, 19.0

p80

p91

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e105 e120

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c252 : 1
stoichiometry:c253 : 1

m108*m123*0.1

nodelay

--

true

0

false

PMID: 18161744,16473764 The receptors for Ox-LDL are in the scavenger receptor family, and include CD36 and a newly described family member termed lectinlike oxidized lipoprotein scavenger receptor (LOX- 1)

Go back
1002.0, 1550.0
19.0, 19.0

p92

p92

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010389 e122 MO000038315

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c256 : 1
stoichiometry:c257 : 1
stoichiometry:c255 : 1

m93364*m125*m16530*0.1

nodelay

--

true

0

false

PMID: 18161744 Extracellular ATP appears to be required for LPS-induced production of IL-1beta and IL-18 from macrophages.

Go back
1026.0, 1446.0
19.0, 19.0

p92

p93

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e123 e122 MO000038315

MO000016625

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c260 : 1
stoichiometry:c261 : 1
stoichiometry:c259 : 1

m126*m125*m16530*0.1

nodelay

--

true

0

false

PMID: 18161744 Extracellular ATP appears to be required for LPS-induced production of IL-1beta and IL-18 from macrophages.

Go back
681.0, 1441.0
21.0, 21.0

p94

p94

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000289

e124

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c262 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 18161744 It has been reported that NALP3 gene expression in primary human monocytes is induced by TNF¦Á and TLR ligands.

Go back
733.0, 1525.0
21.0, 21.0

p94

p95

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e125

e124

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c264 : 1
stoichiometry:c265 : 1

m128*0.1

nodelay

--

true

0

false

PMID: 18161744 It has been reported that NALP3 gene expression in primary human monocytes is induced by TNF¦Á and TLR ligands.

Go back
1054.0, 1702.0
19.0, 19.0

p96

p96

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e126 e127

e128

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c266 : 1
stoichiometry:c267 : 1
stoichiometry:c268 : 1

m129*m130*0.1

nodelay

--

true

0

false

PMID: 18161744,16407890 In addition to ATP, other molecules have the potential to interact with NALP3, including nigericin, maitotoxin, Staphylococcus aureus and Listeria monocytogenes, and RNA released from dying cells

Go back
986.0, 1750.0
19.0, 19.0

p96

p97

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e129 e126

e130

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c270 : 1
stoichiometry:c271 : 1

m132*m129*0.1

nodelay

--

true

0

false

PMID: 18161744,16407890 In addition to ATP, other molecules have the potential to interact with NALP3, including nigericin, maitotoxin, Staphylococcus aureus and Listeria monocytogenes, and RNA released from dying cells

Go back
1038.0, 1738.0
19.0, 19.0

p96

p98

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e126 e131

e132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c272 : 1
stoichiometry:c273 : 1
stoichiometry:c274 : 1

m129*m134*0.1

nodelay

--

true

0

false

PMID: 18161744,16407890 In addition to ATP, other molecules have the potential to interact with NALP3, including nigericin, maitotoxin, Staphylococcus aureus and Listeria monocytogenes, and RNA released from dying cells

Go back
874.0, 1778.0
19.0, 19.0

p96

p99

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e126 e133

e134

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c275 : 1
stoichiometry:c276 : 1
stoichiometry:c277 : 1

m129*m136*0.1

nodelay

--

true

0

false

PMID: 18161744,16407890 In addition to ATP, other molecules have the potential to interact with NALP3, including nigericin, maitotoxin, Staphylococcus aureus and Listeria monocytogenes, and RNA released from dying cells

Go back
429.0, 212.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
902.017314527883, 324.9350533174868

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
411.6936121351536, 1134.381273397555

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.0, 1133.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
364.65685424949237, 1092.6568542494924

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.4132406834243, 1228.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.0, 1305.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
458.0, 1416.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.0, 1510.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
464.0, 1381.4266914845612

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
719.9220899170605, 1390.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
436.46368627598906, 620.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
909.0, 308.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
346.0, 807.8216931327064

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
421.0, 801.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
886.0, 609.8093848167788

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
959.1784904247103, 626.9127214230546

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
898.0459984420344, 619.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
386.0, 730.0256850692869

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
678.9228860501228, 686.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
547.5428375249235, 739.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
543.0, 914.0

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
702.0, 948.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
835.0, 272.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
621.9015837607813, 955.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
615.0, 1000.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
714.0, 1000.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
625.0907907856387, 1006.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
615.0, 1005.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
804.5685159055888, 976.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
802.0, 1004.266928480466

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.98563876372623, 1041.4791383258237

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.0, 1008.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.0, 1048.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
920.0, 278.816

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
708.8154372085236, 999.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
490.0, 1048.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
693.0, 1057.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
837.9910868999311, 1093.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
586.0, 1132.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
578.6136782164077, 1183.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.9102312071875, 1105.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
644.0, 1143.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.5923353935949, 1107.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
733.2641397485555, 1159.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1164.0, 289.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.3400013724057, 1288.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
547.0, 1346.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
582.0, 1288.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.0, 1346.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.0, 1256.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.4063251078693, 1314.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.0, 1256.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
704.0, 1330.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.0, 1244.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
621.3296771047214, 1322.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1173.0, 278.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
735.0, 1244.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
715.6296014490381, 1346.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.0, 297.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.8572415351372, 411.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
785.0, 440.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1170.1018976183914, 464.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1147.2266986386528, 578.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
935.0, 1516.0

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1111.0, 1457.398612773923

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1103.123928123589, 469.0

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
334.70256002616804, 297.1611499353997

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.0, 293.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1028.0, 379.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1037.0, 451.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1041.414606097577, 737.0

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
836.0, 1418.991445467819

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1045.0, 1355.3755667599196

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.0, 295.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1053.0, 532.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1044.0, 541.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1095.1898088913156, 540.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
327.0, 221.85528484893615

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1104.8402447129904, 658.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1094.0, 697.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
934.0, 1339.7999954687552

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1030.0, 1254.8639184245237

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1028.089104705009, 797.0

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1012.5578889249033, 953.0

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
926.0, 1137.7800919753217

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1006.0, 1124.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
774.0, 1625.0

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1086.0, 1636.0

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1001.1689859937185, 235.10586470508

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1080.9209864587033, 962.0

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
774.0, 1593.9464967105803

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1030.0, 1593.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1025.161412024047, 797.0

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1344.268036862948, 1100.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1270.833070699734, 1163.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1269.3601918319166, 1135.1348965210016

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1369.550416732923, 830.9810426273839

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1249.0, 586.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1262.2362938956464, 823.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
997.0, 226.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1388.0, 579.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.0, 303.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1258.104939246337, 571.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1389.0, 1100.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1395.0, 1172.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
935.0, 1437.7773400568078

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1160.0, 1433.0

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1153.8552848489362, 586.0

c197

c197

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
935.0, 1475.631634032896

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1167.364654255002, 1438.1243987748494

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
433.0, 227.40579702813878

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
364.94895460234716, 297.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1151.8624852941507, 1474.4769309392327

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1144.0, 1453.809384816779

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.0, 313.0

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
491.0, 1559.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
543.6568542494924, 1554.0

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.7585526044338, 1606.2804166494748

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.20315111692247, 313.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
794.0, 1277.0

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
206.7839864320407, 516.0

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
112.0, 1368.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
203.0, 349.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
130.28590302650147, 1390.0

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
124.0, 1444.0

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
463.8747738316627, 962.0

c212

c212

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
458.0, 1477.6058500848515

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.0, 1645.4526209558805

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
662.0, 1632.0

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
666.0, 1675.006034118021

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
653.0, 1701.9903426964997

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
72.84251698292468, 1580.0

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
80.30105316484278, 1585.0

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
202.7280699745334, 387.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
859.0, 1184.451643978432

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1018.0, 1180.0

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
429.0, 313.0

c222

c222

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
842.0, 1184.4

c223

c223

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
910.0, 1171.0

c224

c224

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
910.021174172383, 586.0

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
250.0, 1223.0

c226

c226

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
293.5523315630031, 1480.5819261136269

c227

c227

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
288.0, 1473.0

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
248.0, 1085.0

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
195.0, 310.6585165042549

c23

c23

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
251.74986367220373, 313.0

c230

c230

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
198.5003060050375, 1075.0

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
259.0, 671.6368274628348

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1040.4705898648626, 580.0

c233

c233

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1033.0, 534.1648593941172

c234

c234

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
253.0, 1223.0

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
321.0, 1380.983752662909

c236

c236

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
279.94390619355954, 1365.0

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
300.0, 1135.0

c238

c238

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
264.0, 1232.7471339191502

c239

c239

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.5454411842006, 1380.171460577133

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
309.0, 1224.0

c240

c240

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.30167207920204, 1284.0

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
329.0, 1365.9426661822708

c242

c242

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.0, 1358.0

c243

c243

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
105.0, 509.4563983243081

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
104.0, 529.0

c245

c245

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
425.0, 313.0

c246

c246

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
105.0, 527.0

c247

c247

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
284.3926904831707, 667.0574707553855

c248

c248

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.0, 669.0

c249

c249

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
861.0, 1367.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
73.0, 1635.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
96.0, 1580.0

c251

c251

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
112.9912253949587, 1752.3745886903887

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
105.0, 1760.0

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
881.0, 1538.0

c254

c254

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1021.0, 1560.0

c255

c255

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1022.024550284402, 1014.0

c256

c256

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.0, 304.0

c257

c257

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
815.0, 1458.052385730966

c258

c258

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1045.0, 1407.315191898443

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
937.0, 1261.70630296902

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1047.4161984817968, 1014.0

c260

c260

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
523.0, 304.0

c261

c261

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
651.2300312726662, 1419.0186363029811

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
710.0, 1452.0

c263

c263

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
761.639977339209, 1541.3729193531117

c264

c264

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
645.2018202350794, 1420.0779162746717

c265

c265

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
965.0, 1705.0

c266

c266

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.0, 1696.0

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1073.0, 1705.6214926735981

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
903.0, 1741.0

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1024.0, 971.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
965.0, 1717.0

c270

c270

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1005.0, 1764.0

c271

c271

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
965.0, 1708.0

c272

c272

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.4667648496245, 1754.871832634471

c273

c273

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1057.0, 1748.0

c274

c274

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
898.214133946304, 1714.0

c275

c275

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.7081432770395, 1793.1411509102888

c276

c276

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.714609183337, 1773.1177358542493

c277

c277

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.9765990892604, 1801.0

c278

c278

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.0, 1784.0

c279

c279

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
805.0, 1448.8623074579189

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
796.9650738084744, 1825.7467256695445

c280

c280

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
705.0, 1824.0

c281

c281

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
531.9465957439147, 1805.9228304734868

c282

c282

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
458.0, 1717.0

c283

c283

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.9080460493156, 1791.209465866366

c284

c284

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
422.0, 1655.869682521359

c285

c285

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
880.0, 1549.0

c286

c286

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
984.0, 1576.7477787588057

c287

c287

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
815.0, 1496.0

c288

c288

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
422.0, 1585.4492567316506

c289

c289

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
841.0, 1358.779341498506

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1064.0, 1416.0791050716798

c290

c290

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
856.991530090643, 569.0

c291

c291

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.0, 309.0

c292

c292

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
207.8299770843672, 578.0

c293

c293

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
772.9288410442297, 570.0646500342075

c294

c294

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.0, 310.0

c295

c295

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
203.50067319238295, 572.0

c296

c296

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
292.4042119849855, 228.0

c297

c297

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
300.0, 368.0134227998981

c298

c298

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
193.0, 387.67259279036847

c299

c299

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
516.0, 222.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
931.3941549121706, 964.907883951425

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1043.3005910576242, 441.0

c300

c300

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
919.0, 380.0

c301

c301

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
858.5887067242306, 514.0

c302

c302

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
289.8190751468791, 695.0

c303

c303

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
289.9952479948287, 805.0

c304

c304

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
282.0, 818.0

c305

c305

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
503.21645747403153, 1311.0

c306

c306

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
506.0, 1382.0

c307

c307

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
110.0, 1297.0

c308

c308

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
423.0, 1450.0

c309

c309

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
923.0, 1058.7270843947456

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1331.0, 657.0

c310

c310

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1382.8362976331207, 662.0

c311

c311

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1376.0, 709.0

c312

c312

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1018.0, 777.334453144719

c313

c313

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1099.5116931692603, 788.6064078549882

c314

c314

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1089.0, 782.0

c315

c315

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1410.0, 1792.0

c316

c316

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1460.0, 1810.0

c317

c317

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1259.0, 1760.6334995795219

c318

c318

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1336.0180979353481, 1760.840091323115

c319

c319

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
916.0, 835.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1266.5174713247359, 1761.0

c320

c320

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1199.0, 1895.0

c321

c321

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1254.5099956953175, 1802.0

c322

c322

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1102.3305043559244, 1892.2037019037002

c323

c323

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1262.0, 1820.8965465162337

c324

c324

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1339.2469504755443, 1757.0

c325

c325

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1258.8646187432907, 1693.0046214722142

c326

c326

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1113.8394971620194, 1537.817313590441

c327

c327

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1141.959184326259, 1483.487348100741

c328

c328

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1156.482624024052, 1443.7150808878548

c329

c329

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
933.3409919128368, 727.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1062.3701422443753, 1903.0

c330

c330

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1068.0437687993774, 1944.79279858428

c331

c331

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.6198061951341, 1895.492011346698

c332

c332

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
364.87008539214537, 1507.4352642519864

c333

c333

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
116.23077947183202, 1305.0177073622717

c334

c334

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
365.78900016042326, 1503.2319589815797

c335

c335

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
520.6568542494924, 1594.0

c336

c336

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
442.09332196164223, 1731.0

c337

c337

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
522.983901475423, 1673.0

c338

c338

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
553.7136508784449, 1594.0

c339

c339

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
925.0, 756.3715705307978

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
446.7999525008906, 1783.0

c340

c340

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
562.9796695986458, 1717.0

c341

c341

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1257.0, 823.915194788644

c342

c342

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1324.0688506262654, 835.3879737298985

c343

c343

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1260.3281261544707, 828.0

c344

c344

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1027.8563614599796, 916.0

c345

c345

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1008.967992780999, 905.0

c346

c346

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
974.7907296779343, 844.8178369248513

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
967.1159660434203, 857.8599434057004

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
956.0, 851.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
866.9646360217126, 725.7513807567653

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
762.0, 724.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.0, 246.1066869567562

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.0793457790559, 845.7259714626609

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
733.8334291527694, 839.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
716.0056408699137, 744.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.0, 792.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
624.4906334205524, 760.8089875327071

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
780.5777087639997, 803.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.0, 872.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
668.9856387637262, 897.4791383258236

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
602.0, 665.9430147078954

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
630.0, 648.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
589.2864409730729, 249.6663020861856

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.0, 648.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
459.84217130815114, 665.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
460.92555965748096, 714.0045753121489

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.0, 714.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
471.0, 871.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.510779149201, 1203.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.5894663844041, 758.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
368.0, 698.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
509.93190679700086, 790.0415635187981

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.63497725054634, 798.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
632.6994814945797, 308.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1254.0, 576.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1320.0, 594.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1259.5099956953175, 586.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
349.0, 476.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.0, 393.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.0, 486.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
494.0, 425.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.0, 390.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.995473888266, 442.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.0, 384.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
532.0, 302.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
905.8121901877114, 475.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
898.0, 499.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
883.0, 544.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.0, 486.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
805.0, 544.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.8275413614842, 500.3792510848185

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
744.0, 434.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
702.9316343643403, 486.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
694.0, 506.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
721.3134161327013, 573.6582051289422

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
594.0, 234.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
667.0, 556.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
494.0, 433.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.5281958488132, 515.6241387262427

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
582.0, 445.93877547342294

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.1554175279994, 563.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.0, 481.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
391.0, 600.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
436.0, 565.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
452.3040696849266, 655.2635204975204

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
386.66914335816205, 657.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
835.0, 277.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
560.0, 623.8166078904625

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
545.0, 538.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
617.0, 608.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
325.19721862065717, 775.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
316.11546676004895, 856.7152317131197

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
320.0, 849.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.3232351592611, 667.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
450.0, 951.188745552877

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
449.05927969280464, 953.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
402.6625609418811, 1063.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back