_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e2
_enti_e4
_enti_e3
_enti_e55
_enti_e53
_enti_e59
_enti_e52
_enti_e50
_enti_e51
_enti_e56
_enti_e54
_enti_e58
_enti_e61
_enti_e57
_enti_e60
_enti_e62
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g14
p1_propro_p1
PMID: 18163952
From fig.1
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 18163952
From fig.1
c4 cso30:c:InputProcess connector
c6 cso30:c:InputProcess connector
c5 cso30:c:OutputProcess connector
p3_propro_p3
c7 cso30:c:InputProcess connector
c8 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 18163952
From fig.1
c10 cso30:c:InputProcess connector
c11 cso30:c:InputProcess connector
c12 cso30:c:OutputProcess connector
p5_propro_p5
c13 cso30:c:InputProcess connector
c14 cso30:c:InputProcess connector
c15 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 18163952, 9759489, 7532278, 9726434
The STAT1 and STAT2 proteins have been reported to be activated by the IFN-α/β via tyrosyl phosphorylation at critical residues, using tyrosine kinases Tyk2 and JAK1.
c16 cso30:c:InputProcess connector
c18 cso30:c:InputAssociation connector
c17 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 18163952, 9759489, 7532278, 9726434
The STAT1 and STAT2 proteins have been reported to be activated by the IFN-α/β via tyrosyl phosphorylation at critical residues, using tyrosine kinases Tyk2 and JAK1.
c19 cso30:c:InputProcess connector
c21 cso30:c:InputAssociation connector
c20 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 18163952, 9759489, 7532278, 9726434
The STAT1 and STAT2 proteins have been reported to be activated by the IFN-α/β via tyrosyl phosphorylation at critical residues, using tyrosine kinases Tyk2 and JAK1.
c22 cso30:c:InputProcess connector
c27 cso30:c:InputAssociation connector
c23 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 18163952, 9759489, 7532278, 9726434
The STAT1 and STAT2 proteins have been reported to be activated by the IFN-α/β via tyrosyl phosphorylation at critical residues, using tyrosine kinases Tyk2 and JAK1.
c24 cso30:c:InputProcess connector
c26 cso30:c:InputAssociation connector
c25 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 18163952, 8417326
After being activated (i.e. tyrosyl phosphorylated) STAT1 and STAT2 heterodimers associate with the non-STAT DNA-binding protein, IFN gene regulatory factor-9 (IRF-9/p48/ISGF3-γ)
c28 cso30:c:InputProcess connector
c29 cso30:c:InputProcess connector
c30 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 18163952, 8417326
After being activated (i.e. tyrosyl phosphorylated) STAT1 and STAT2 heterodimers associate with the non-STAT DNA-binding protein, IFN gene regulatory factor-9 (IRF-9/p48/ISGF3-γ)
c31 cso30:c:InputProcess connector
c32 cso30:c:InputProcess connector
c33 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 18163952
The resultant trimeric transcription factor, ISGF3, binds to the IFN-stimulated regulatory elements (ISREs) to induce the expression of many IFN-α/β-regulated genes.
c34 cso30:c:InputProcess connector
c36 cso30:c:InputProcess connector
c35 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 18163952
The resultant trimeric transcription factor, ISGF3, binds to the IFN-stimulated regulatory elements (ISREs) to induce the expression of many IFN-α/β-regulated genes.
c37 cso30:c:InputAssociation connector
c38 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 18163952
From fig.1
c39 cso30:c:InputProcess connector
c41 cso30:c:InputProcess connector
c40 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 18163952
From fig.1
c42 cso30:c:InputProcess connector
c43 cso30:c:InputProcess connector
c44 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 18163952
From fig.1
c45 cso30:c:InputProcess connector
c46 cso30:c:InputProcess connector
c47 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 18163952
From fig.1
c48 cso30:c:InputProcess connector
c49 cso30:c:InputProcess connector
c50 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 18163952
Only the STAT1 protein is tyrosyl phosphorylated by JAK1 and JAK2 at the ligand engaged type II IFN receptor.
c51 cso30:c:InputProcess connector
c53 cso30:c:InputAssociation connector
c52 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 18163952, 7690989
STAT1 dimers, thus formed, migrate to the nucleus, bind to the γ-IFN-activated sequence (GAS) to drive γ-IFN-induced gene expression
c54 cso30:c:InputProcess connector
c55 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 18163952, 7690989
STAT1 dimers, thus formed, migrate to the nucleus, bind to the γ-IFN-activated sequence (GAS) to drive γ-IFN-induced gene expression
c56 cso30:c:InputProcess connector
c57 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 18163952, 7690989
STAT1 dimers, thus formed, migrate to the nucleus, bind to the γ-IFN-activated sequence (GAS) to drive γ-IFN-induced gene expression
c58 cso30:c:InputProcess connector
c60 cso30:c:InputProcess connector
c59 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 18163952, 7690989
STAT1 dimers, thus formed, migrate to the nucleus, bind to the γ-IFN-activated sequence (GAS) to drive γ-IFN-induced gene expression
c61 cso30:c:InputAssociation connector
c62 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 18163952, 15166220
The ligand-bound type III IFN receptor, although activated in a manner similar to the type I receptor, activates multiple STATs-STAT1, STAT2, STAT3, STAT4 and STAT5
c63 cso30:c:InputProcess connector
c64 cso30:c:InputProcess connector
c65 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 18163952, 15166220
The ligand-bound type III IFN receptor, although activated in a manner similar to the type I receptor, activates multiple STATs-STAT1, STAT2, STAT3, STAT4 and STAT5
c66 cso30:c:InputProcess connector
c68 cso30:c:InputAssociation connector
c67 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 18163952, 15166220
The ligand-bound type III IFN receptor, although activated in a manner similar to the type I receptor, activates multiple STATs-STAT1, STAT2, STAT3, STAT4 and STAT5
c69 cso30:c:InputProcess connector
c71 cso30:c:InputAssociation connector
c70 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 18163952, 15166220
The ligand-bound type III IFN receptor, although activated in a manner similar to the type I receptor, activates multiple STATs-STAT1, STAT2, STAT3, STAT4 and STAT5
c72 cso30:c:InputProcess connector
c74 cso30:c:InputAssociation connector
c73 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 18163952, 15166220
The ligand-bound type III IFN receptor, although activated in a manner similar to the type I receptor, activates multiple STATs-STAT1, STAT2, STAT3, STAT4 and STAT5
c75 cso30:c:InputProcess connector
c77 cso30:c:InputAssociation connector
c76 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 18163952, 15166220
The ligand-bound type III IFN receptor, although activated in a manner similar to the type I receptor, activates multiple STATs-STAT1, STAT2, STAT3, STAT4 and STAT5
c78 cso30:c:InputProcess connector
c80 cso30:c:InputAssociation connector
c79 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 18163952, 10878008, 10523304
some studies have shown p38α is phosphorylated and activated in a type-I-IFN-dependent manner in several IFN-sensitive cell lines.
c81 cso30:c:InputProcess connector
c85 cso30:c:InputAssociation connector
c82 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 18163952, 10878008, 10523304
some studies have shown p38α is phosphorylated and activated in a type-I-IFN-dependent manner in several IFN-sensitive cell lines.
c83 cso30:c:InputProcess connector
c86 cso30:c:InputAssociation connector
c84 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 18163952, 15864272
The PI3K-signaling cascade also regulates IFN inducible activation of the mammalian target of rapamycin (mTOR), via Akt, which mediates the initiation of mRNA translation
c87 cso30:c:InputProcess connector
c89 cso30:c:InputAssociation connector
c88 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 18163952, 15864272
The PI3K-signaling cascade also regulates IFN inducible activation of the mammalian target of rapamycin (mTOR), via Akt, which mediates the initiation of mRNA translation
c90 cso30:c:InputProcess connector
c92 cso30:c:InputAssociation connector
c91 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 18163952, 15864272
The PI3K-signaling cascade also regulates IFN inducible activation of the mammalian target of rapamycin (mTOR), via Akt, which mediates the initiation of mRNA translation
c93 cso30:c:InputProcess connector
c95 cso30:c:InputAssociation connector
c94 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 18163952, 15864272
The PI3K-signaling cascade also regulates IFN inducible activation of the mammalian target of rapamycin (mTOR), via Akt, which mediates the initiation of mRNA translation
c96 cso30:c:InputProcess connector
c98 cso30:c:InputAssociation connector
c97 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 18163952, 15864272
The PI3K-signaling cascade also regulates IFN inducible activation of the mammalian target of rapamycin (mTOR), via Akt, which mediates the initiation of mRNA translation
c99 cso30:c:InputAssociation connector
c100 cso30:c:InputAssociation connector
p36_propro_p36
PMID: 18163952, 9238507
C/EBP-β also regulates IL-6 and IL-6-induced expression of the cytokines IL-1, IL-8, tumor necrosis factor-α (TNF-α), and granulocyte colony-stimulating factor (G-CSF), as well acute phase response proteins such as α1-acid glycoprotein, α2-microglobulin, and C-reactive protein
c101 cso30:c:InputProcess connector
c103 cso30:c:InputAssociation connector
c102 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 18163952, 9238507
C/EBP-β also regulates IL-6 and IL-6-induced expression of the cytokines IL-1, IL-8, tumor necrosis factor-α (TNF-α), and granulocyte colony-stimulating factor (G-CSF), as well acute phase response proteins such as α1-acid glycoprotein, α2-microglobulin, and C-reactive protein
c104 cso30:c:InputAssociation connector
c105 cso30:c:OutputProcess connector
p39_propro_p39
c107 cso30:c:InputAssociation connector
c106 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 18163952, 9238507
C/EBP-β also regulates IL-6 and IL-6-induced expression of the cytokines IL-1, IL-8, tumor necrosis factor-α (TNF-α), and granulocyte colony-stimulating factor (G-CSF), as well acute phase response proteins such as α1-acid glycoprotein, α2-microglobulin, and C-reactive protein
c108 cso30:c:InputAssociation connector
c109 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 18163952, 9238507
C/EBP-β also regulates IL-6 and IL-6-induced expression of the cytokines IL-1, IL-8, tumor necrosis factor-α (TNF-α), and granulocyte colony-stimulating factor (G-CSF), as well acute phase response proteins such as α1-acid glycoprotein, α2-microglobulin, and C-reactive protein
c110 cso30:c:InputAssociation connector
c111 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 18163952, 9238507
C/EBP-β also regulates IL-6 and IL-6-induced expression of the cytokines IL-1, IL-8, tumor necrosis factor-α (TNF-α), and granulocyte colony-stimulating factor (G-CSF), as well acute phase response proteins such as α1-acid glycoprotein, α2-microglobulin, and C-reactive protein
c112 cso30:c:InputAssociation connector
c113 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 18163952, 9238507
C/EBP-β also regulates IL-6 and IL-6-induced expression of the cytokines IL-1, IL-8, tumor necrosis factor-α (TNF-α), and granulocyte colony-stimulating factor (G-CSF), as well acute phase response proteins such as α1-acid glycoprotein, α2-microglobulin, and C-reactive protein
c115 cso30:c:InputAssociation connector
c114 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 18163952, 9238507
C/EBP-β also regulates IL-6 and IL-6-induced expression of the cytokines IL-1, IL-8, tumor necrosis factor-α (TNF-α), and granulocyte colony-stimulating factor (G-CSF), as well acute phase response proteins such as α1-acid glycoprotein, α2-microglobulin, and C-reactive protein
c117 cso30:c:InputAssociation connector
c116 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 18163952, 8321203, 8552662, 9121452, 11238899
C/EBP-β can interact with transcription factors outside its family, such as NF-κB (84), retinoblastoma (pRb) tumor suppressor protein (85), Sp1 (86), STAT3 (87) to regulate cellular functions.
c118 cso30:c:InputProcess connector
c119 cso30:c:InputProcess connector
c120 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 18163952, 8321203, 8552662, 9121452, 11238899
C/EBP-β can interact with transcription factors outside its family, such as NF-κB (84), retinoblastoma (pRb) tumor suppressor protein (85), Sp1 (86), STAT3 (87) to regulate cellular functions.
PMID: 18163952, 7959007, 8756629, 8552662, 9121452
C/EBP-β binds to a variety of response elements and forms heteromeric complexes with other transcription factors, such as pRb, NF-κB, Sp1, Myb and PU.1
c121 cso30:c:InputProcess connector
c122 cso30:c:InputProcess connector
c123 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 18163952, 8321203, 8552662, 9121452, 11238899
C/EBP-β can interact with transcription factors outside its family, such as NF-κB (84), retinoblastoma (pRb) tumor suppressor protein (85), Sp1 (86), STAT3 (87) to regulate cellular functions.
PMID: 18163952, 7959007, 8756629, 8552662, 9121452
C/EBP-β binds to a variety of response elements and forms heteromeric complexes with other transcription factors, such as pRb, NF-κB, Sp1, Myb and PU.1
c124 cso30:c:InputProcess connector
c125 cso30:c:InputProcess connector
c126 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 18163952, 8321203, 8552662, 9121452, 11238899
C/EBP-β can interact with transcription factors outside its family, such as NF-κB (84), retinoblastoma (pRb) tumor suppressor protein (85), Sp1 (86), STAT3 (87) to regulate cellular functions.
PMID: 18163952, 7959007, 8756629, 8552662, 9121452
C/EBP-β binds to a variety of response elements and forms heteromeric complexes with other transcription factors, such as pRb, NF-κB, Sp1, Myb and PU.1
c127 cso30:c:InputProcess connector
c128 cso30:c:InputProcess connector
c129 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 18163952, 1934061
LIP dominantly inhibits the transcriptional activity of the full-length C/EBP-beta by dimerizing with it.
c130 cso30:c:InputProcess connector
c131 cso30:c:InputProcess connector
c132 cso30:c:OutputProcess connector
p49_propro_p49
PMID: 18163952, 1547942
It can form heterodimers with C/EBP-α and C/EBP-β, and attenuate their transcriptional activity
c133 cso30:c:InputProcess connector
c134 cso30:c:InputProcess connector
c135 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 18163952, 1547942
It can form heterodimers with C/EBP-α and C/EBP-β, and attenuate their transcriptional activity
c136 cso30:c:InputProcess connector
c137 cso30:c:InputProcess connector
c138 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 18163952, 2112087
LPS, IL-6, IL-1, dexamethasone, and glucagon can strongly up-regulate the expression of C/EBP-β
c141 cso30:c:InputAssociation connector
c139 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 18163952, 2112087
LPS, IL-6, IL-1, dexamethasone, and glucagon can strongly up-regulate the expression of C/EBP-β
c142 cso30:c:InputAssociation connector
c140 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 18163952, 2112087
LPS, IL-6, IL-1, dexamethasone, and glucagon can strongly up-regulate the expression of C/EBP-β
c145 cso30:c:InputAssociation connector
c143 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 18163952, 2112087
LPS, IL-6, IL-1, dexamethasone, and glucagon can strongly up-regulate the expression of C/EBP-β
c146 cso30:c:InputAssociation connector
c144 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 18163952, 10777554
We have shown that IFN-γ not only induces the expression of C/EBP-β but also enhances its transcriptional activity
c150 cso30:c:InputAssociation connector
c148 cso30:c:OutputProcess connector
p56_propro_p56
PMID: 18163952, 2112087
LPS, IL-6, IL-1, dexamethasone, and glucagon can strongly up-regulate the expression of C/EBP-β
c149 cso30:c:InputAssociation connector
c147 cso30:c:OutputProcess connector
p57_propro_p57
PMID: 18163952, 8336793, 8384717, 10635333, 11684016
Posttranscriptional modifications of C/EBP by protein kinases PKA, PKC,ribosomal S6 kinase (RSK), and extracellular signal-related kinase (ERK) appear to modulate its activity in different cells
c151 cso30:c:InputProcess connector
c164 cso30:c:InputAssociation connector
c152 cso30:c:OutputProcess connector
p58_propro_p58
PMID: 18163952, 8336793, 8384717, 10635333, 11684016
Posttranscriptional modifications of C/EBP by protein kinases PKA, PKC,ribosomal S6 kinase (RSK), and extracellular signal-related kinase (ERK) appear to modulate its activity in different cells
c153 cso30:c:InputProcess connector
c166 cso30:c:InputAssociation connector
c154 cso30:c:OutputProcess connector
p59_propro_p59
PMID: 18163952, 8336793, 8384717, 10635333, 11684016
Posttranscriptional modifications of C/EBP by protein kinases PKA, PKC,ribosomal S6 kinase (RSK), and extracellular signal-related kinase (ERK) appear to modulate its activity in different cells
c155 cso30:c:InputProcess connector
c165 cso30:c:InputAssociation connector
c156 cso30:c:OutputProcess connector
p60_propro_p60
PMID: 18163952, 8336793, 8384717, 10635333, 11684016
Posttranscriptional modifications of C/EBP by protein kinases PKA, PKC,ribosomal S6 kinase (RSK), and extracellular signal-related kinase (ERK) appear to modulate its activity in different cells
c157 cso30:c:InputProcess connector
c159 cso30:c:InputAssociation connector
c158 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 18163952, 10777554, 11312260
We have shown that C/EBP-β binds to GATE and stimulates transcription
c160 cso30:c:InputProcess connector
c162 cso30:c:InputProcess connector
c161 cso30:c:OutputProcess connector
p62_propro_p62
PMID: 18163952, 10777554, 11312260
We have shown that C/EBP-β binds to GATE and stimulates transcription
c163 cso30:c:InputAssociation connector
p63_propro_p63
PMID: 18163952, 7959007, 8756629, 8552662, 9121452
C/EBP-β binds to a variety of response elements and forms heteromeric complexes with other transcription factors, such as pRb, NF-κB, Sp1, Myb and PU.1
c167 cso30:c:InputProcess connector
c168 cso30:c:InputProcess connector
c169 cso30:c:OutputProcess connector
p64_propro_p64
PMID: 18163952, 7959007, 8756629, 8552662, 9121452
C/EBP-β binds to a variety of response elements and forms heteromeric complexes with other transcription factors, such as pRb, NF-κB, Sp1, Myb and PU.1
c170 cso30:c:InputProcess connector
c171 cso30:c:InputProcess connector
c172 cso30:c:OutputProcess connector
p65_propro_p65
PMID: 18163952, 11004486
IL-6 induces IRF-9 gene expression through GATE using C/EBP-β
c173 cso30:c:InputAssociation connector
c174 cso30:c:OutputProcess connector
p66_propro_p66
PMID: 18163952, 1888886
IL-6 induces the expression of 2-5A synthetase and MHC class I genes
c175 cso30:c:InputAssociation connector
c176 cso30:c:OutputProcess connector
p67_propro_p67
PMID: 18163952, 1888886
IL-6 induces the expression of 2-5A synthetase and MHC class I genes
c178 cso30:c:InputAssociation connector
c177 cso30:c:OutputProcess connector
p68_propro_p68
c179 cso30:c:InputProcess connector
c181 cso30:c:InputProcess connector
c180 cso30:c:OutputProcess connector
p69_propro_p69
PMID: 18163952, 11057895
Ras activation is dependent on the recruitment of the adaptor proteins Grb and Sos to the growth factor receptors
c182 cso30:c:InputProcess connector
c183 cso30:c:InputProcess connector
c184 cso30:c:InputProcess connector
c185 cso30:c:OutputProcess connector
p70_propro_p70
PMID: 18163952, 11057895
Ras activation is dependent on the recruitment of the adaptor proteins Grb and Sos to the growth factor receptors
c186 cso30:c:InputProcess connector
c188 cso30:c:InputAssociation connector
c187 cso30:c:OutputProcess connector
p71_propro_p71
PMID: 18163952
Raf, a serine-threonine kinase, responds to Ras and phosphorylates MAP kinase kinase 1 (MEK1).
c189 cso30:c:InputProcess connector
c191 cso30:c:InputAssociation connector
c190 cso30:c:OutputProcess connector
p72_propro_p72
PMID: 18163952
Raf, a serine-threonine kinase, responds to Ras and phosphorylates MAP kinase kinase 1 (MEK1).
c192 cso30:c:InputProcess connector
c194 cso30:c:InputAssociation connector
c193 cso30:c:OutputProcess connector
p73_propro_p73
PMID: 18163952
MEK1, a dual specificity kinase, phosphorylates at the conserved threonine and tyrosine residues present in the activation loop of ERKs: ERK1 (p44) and ERK2 (p42).
c195 cso30:c:InputProcess connector
c197 cso30:c:InputAssociation connector
c196 cso30:c:OutputProcess connector
p74_propro_p74
PMID: 18163952
MEK1, a dual specificity kinase, phosphorylates at the conserved threonine and tyrosine residues present in the activation loop of ERKs: ERK1 (p44) and ERK2 (p42).
c198 cso30:c:InputProcess connector
c200 cso30:c:InputAssociation connector
c199 cso30:c:OutputProcess connector
p75_propro_p75
PMID: 18163952
ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.
c201 cso30:c:InputAssociation connector
c203 cso30:c:InputProcess connector
c204 cso30:c:OutputProcess connector
p76_propro_p76
PMID: 18163952
ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.
c202 cso30:c:InputAssociation connector
c205 cso30:c:InputProcess connector
c206 cso30:c:OutputProcess connector
p77_propro_p77
PMID: 18163952
ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.
c207 cso30:c:InputAssociation connector
c209 cso30:c:InputProcess connector
c210 cso30:c:OutputProcess connector
p78_propro_p78
PMID: 18163952
ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.
c208 cso30:c:InputAssociation connector
c211 cso30:c:InputProcess connector
c212 cso30:c:OutputProcess connector
p79_propro_p79
PMID: 18163952
ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.
c213 cso30:c:InputAssociation connector
c215 cso30:c:InputProcess connector
c217 cso30:c:OutputProcess connector
p80_propro_p80
PMID: 18163952
ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.
c214 cso30:c:InputAssociation connector
c216 cso30:c:InputProcess connector
c218 cso30:c:OutputProcess connector
p81_propro_p81
PMID: 18163952
ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.
c220 cso30:c:InputAssociation connector
c222 cso30:c:InputProcess connector
c224 cso30:c:OutputProcess connector
p82_propro_p82
PMID: 18163952
ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.
c219 cso30:c:InputAssociation connector
c221 cso30:c:InputProcess connector
c223 cso30:c:OutputProcess connector
p83_propro_p83
PMID: 18163952, 9199317, 9668040
Raf activation by IFN-γ and IFN-β has been reported
c225 cso30:c:InputProcess connector
c227 cso30:c:InputAssociation connector
c226 cso30:c:OutputProcess connector
p84_propro_p84
PMID: 18163952, 9199317, 9668040
Raf activation by IFN-γ and IFN-β has been reported
c228 cso30:c:InputProcess connector
c230 cso30:c:InputAssociation connector
c229 cso30:c:OutputProcess connector
p85_propro_p85
PMID: 18163952, 9305638
Rho and Rac, the G proteins similar to Ras, are activated first
c231 cso30:c:InputProcess connector
c233 cso30:c:InputAssociation connector
c232 cso30:c:OutputProcess connector
p86_propro_p86
PMID: 18163952, 9305638
Rho and Rac, the G proteins similar to Ras, are activated first
c234 cso30:c:InputProcess connector
c236 cso30:c:InputAssociation connector
c235 cso30:c:OutputProcess connector
p87_propro_p87
PMID: 18163952, 9305638
Rho and Rac, the G proteins similar to Ras, are activated first
c237 cso30:c:InputProcess connector
c239 cso30:c:InputAssociation connector
c238 cso30:c:OutputProcess connector
p88_propro_p88
c240 cso30:c:InputProcess connector
c242 cso30:c:InputAssociation connector
c241 cso30:c:OutputProcess connector
p89_propro_p89
PMID: 18163952
These G-proteins then activate MAP kinase kinase kinases (MEKKs)
c243 cso30:c:InputProcess connector
c245 cso30:c:InputAssociation connector
c244 cso30:c:OutputProcess connector
p90_propro_p90
PMID: 18163952
These G-proteins then activate MAP kinase kinase kinases (MEKKs)
c246 cso30:c:InputProcess connector
c248 cso30:c:InputAssociation connector
c247 cso30:c:OutputProcess connector
p91_propro_p91
PMID: 18163952
MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (α, β, γ, δ) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes
SEK1/2.
c249 cso30:c:InputProcess connector
c251 cso30:c:InputAssociation connector
c250 cso30:c:OutputProcess connector
p92_propro_p92
PMID: 18163952
MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (α, β, γ, δ) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes
SEK1/2.
c252 cso30:c:InputProcess connector
c254 cso30:c:InputAssociation connector
c253 cso30:c:OutputProcess connector
p93_propro_p93
PMID: 18163952
MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (α, β, γ, δ) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes
SEK1/2.
c257 cso30:c:InputProcess connector
c259 cso30:c:InputAssociation connector
c258 cso30:c:OutputProcess connector
p94_propro_p94
PMID: 18163952
MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (α, β, γ, δ) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes
SEK1/2.
c255 cso30:c:InputProcess connector
c260 cso30:c:InputAssociation connector
c256 cso30:c:OutputProcess connector
p95_propro_p95
PMID: 18163952
MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (α, β, γ, δ) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes
SEK1/2.
c264 cso30:c:InputProcess connector
c266 cso30:c:InputAssociation connector
c265 cso30:c:OutputProcess connector
p96_propro_p96
PMID: 18163952
MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (α, β, γ, δ) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes
SEK1/2.
c261 cso30:c:InputProcess connector
c263 cso30:c:InputAssociation connector
c262 cso30:c:OutputProcess connector
p97_propro_p97
PMID: 18163952
MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (α, β, γ, δ) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes
SEK1/2.
c269 cso30:c:InputProcess connector
c272 cso30:c:InputAssociation connector
c270 cso30:c:OutputProcess connector
p98_propro_p98
PMID: 18163952
MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (α, β, γ, δ) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes
SEK1/2.
c267 cso30:c:InputProcess connector
c271 cso30:c:InputAssociation connector
c268 cso30:c:OutputProcess connector
p99_propro_p99
PMID: 18163952
MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (α, β, γ, δ) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes
SEK1/2.
c275 cso30:c:InputProcess connector
c277 cso30:c:InputAssociation connector
c276 cso30:c:OutputProcess connector
p100_propro_p100
PMID: 18163952
MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (α, β, γ, δ) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes
SEK1/2.
c273 cso30:c:InputProcess connector
c278 cso30:c:InputAssociation connector
c274 cso30:c:OutputProcess connector
p101_propro_p101
PMID: 18163952
MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (α, β, γ, δ) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes
SEK1/2.
c281 cso30:c:InputProcess connector
c283 cso30:c:InputAssociation connector
c282 cso30:c:OutputProcess connector
p102_propro_p102
PMID: 18163952
MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (α, β, γ, δ) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes
SEK1/2.
c279 cso30:c:InputProcess connector
c284 cso30:c:InputAssociation connector
c280 cso30:c:OutputProcess connector
p103_propro_p103
PMID: 18163952, 12048245
Instead of Raf, MEKK1 was required for IFN-γ-induced ERK activation and the induction IRF-9 gene
c285 cso30:c:InputProcess connector
c287 cso30:c:InputAssociation connector
c286 cso30:c:OutputProcess connector
p104_propro_p104
PMID: 18163952, 12048245
Instead of Raf, MEKK1 was required for IFN-γ-induced ERK activation and the induction IRF-9 gene
c288 cso30:c:InputProcess connector
c290 cso30:c:InputAssociation connector
c289 cso30:c:OutputProcess connector
p105_propro_p105
PMID: 18163952, 12048245
Instead of Raf, MEKK1 was required for IFN-γ-induced ERK activation and the induction IRF-9 gene
c292 cso30:c:InputAssociation connector
c291 cso30:c:OutputProcess connector
p106_propro_p106
PMID: 18163952, 10969079
This domain acts as a scaffold for the binding of MEK1 and ERK1/2, which permits the juxtaposition of the kinases and their activation.
c293 cso30:c:InputProcess connector
c294 cso30:c:InputProcess connector
c295 cso30:c:InputProcess connector
c296 cso30:c:InputProcess connector
c297 cso30:c:OutputProcess connector
p107_propro_p107
PMID: 18163952, 7624324
MEKK1 phosphorylates MEK1 on the same residue as does Raf
c298 cso30:c:InputProcess connector
c300 cso30:c:InputAssociation connector
c299 cso30:c:OutputProcess connector
p108_propro_p108
PMID: 18163952, 10346818, 9689078, 10805784
MEKK1 is also required for the activation of NF-κB and c-Jun N-terminal kinases
c301 cso30:c:InputProcess connector
c303 cso30:c:InputAssociation connector
c302 cso30:c:OutputProcess connector
p109_propro_p109
PMID: 18163952, 10346818, 9689078, 10805784
MEKK1 is also required for the activation of NF-κB and c-Jun N-terminal kinases
c304 cso30:c:InputProcess connector
c306 cso30:c:InputAssociation connector
c305 cso30:c:OutputProcess connector
p110_propro_p110
PMID: 18163952, 10747925
It also plays a major role in IFN-β gene induction
c308 cso30:c:InputAssociation connector
c307 cso30:c:OutputProcess connector
p111_propro_p111
PMID: 18163952, 14759369
One recent study showed that Ras induces phosphorylation of C/EBP-β and activated C/EBP-β interacts with the transcriptional
mediator complex
c309 cso30:c:InputProcess connector
c311 cso30:c:InputAssociation connector
c310 cso30:c:OutputProcess connector
p112_propro_p112
PMID: 18163952, 14759369
One recent study showed that Ras induces phosphorylation of C/EBP-β and activated C/EBP-β interacts with the transcriptional mediator complex
c312 cso30:c:InputProcess connector
c314 cso30:c:InputProcess connector
c313 cso30:c:OutputProcess connector
p113_propro_p113
PMID: 18163952, 12050152
GATE also binds another transcriptional activator, GBF1, in response to IFN-γ
c315 cso30:c:InputProcess connector
c316 cso30:c:InputProcess connector
c318 cso30:c:InputAssociation connector
c317 cso30:c:OutputProcess connector
p114_propro_p114
PMID: 18163952, 10657627
CRKL is tyrosine phosphorylated during IFN-treatment
c319 cso30:c:InputProcess connector
c321 cso30:c:InputAssociation connector
c320 cso30:c:OutputProcess connector
p115_propro_p115
PMID: 18163952
Mutation of this motif and/or interference with the ERK1/2 activation prevented the IFN-γ-induced association between GBF1 and C/EBP-β.
c322 cso30:c:InputProcess connector
c323 cso30:c:InputProcess connector
c325 cso30:c:InputAssociation connector
c324 cso30:c:OutputProcess connector
p116_propro_p116
PMID: 18163952, 15879117
Our subsequent studies have shown that GBF1 recruitment to the IRF-9 promoter is dependent on C/EBP-β.
c326 cso30:c:InputProcess connector
c327 cso30:c:InputProcess connector
c328 cso30:c:OutputProcess connector
p117_propro_p117
PMID: 18163952, 10799501
Signal induced binding of Cdc42/Rac to the CRIB causes MLK dimerization, leading to their autophosphorylation
c329 cso30:c:InputProcess connector
c331 cso30:c:InputProcess connector
c330 cso30:c:OutputProcess connector
p118_propro_p118
PMID: 18163952, 10799501
Signal induced binding of Cdc42/Rac to the CRIB causes MLK dimerization, leading to their autophosphorylation
c332 cso30:c:InputProcess connector
c333 cso30:c:OutputProcess connector
p119_propro_p119
PMID: 18163952, 10799501
Signal induced binding of Cdc42/Rac to the CRIB causes MLK dimerization, leading to their autophosphorylation
c334 cso30:c:InputProcess connector
c335 cso30:c:OutputProcess connector
p120_propro_p120
PMID: 18163952, 9003778, 11432832
MLKs function as MKKKs and have been implicated in the activation of JNK and SEK1 and transcription factor NF-κB
c336 cso30:c:InputProcess connector
c338 cso30:c:InputAssociation connector
c337 cso30:c:OutputProcess connector
p121_propro_p121
PMID: 18163952, 9003778, 11432832
MLKs function as MKKKs and have been implicated in the activation of JNK and SEK1 and transcription factor NF-κB
c340 cso30:c:InputProcess connector
c341 cso30:c:InputAssociation connector
c339 cso30:c:OutputProcess connector
p122_propro_p122
PMID: 18163952, 9003778, 11432832
MLKs function as MKKKs and have been implicated in the activation of JNK and SEK1 and transcription factor NF-κB
c342 cso30:c:InputProcess connector
c344 cso30:c:InputAssociation connector
c343 cso30:c:OutputProcess connector
p123_propro_p123
PMID: 18163952, 9003778, 11432832
MLKs function as MKKKs and have been implicated in the activation of JNK and SEK1 and transcription factor NF-κB
c345 cso30:c:InputProcess connector
c347 cso30:c:InputAssociation connector
c346 cso30:c:OutputProcess connector
p124_propro_p124
PMID: 18163952
co-expression of MLK3, but not MLK2, significantly stimulated the IFN-γ-induced expression of IRF-9.
c349 cso30:c:InputAssociation connector
c350 cso30:c:InputAssociation connector
c348 cso30:c:OutputProcess connector
p125_propro_p125
PMID: 18163952, 15314150
One likely candidate is Cdk2, which phosphorylates C/EBP-β in vitro at S64 and T189
PMID: 18163952, 8755534
IFN-γ treatment has been shown to cause a decrease in Cdk2 activity
c351 cso30:c:InputProcess connector
c353 cso30:c:InputAssociation connector
c354 cso30:c:InputInhibitor connector
c352 cso30:c:OutputProcess connector
p126_propro_p126
PMID: 18163952
IFN-γ treatment decreased S64 phosphorylation. Surprisingly, MLK3 caused a decrease in phosphorylation of C/EBP-β instead of its stimulation in an IFN-γ dependent manner.
c355 cso30:c:InputProcess connector
c357 cso30:c:InputInhibitor connector
c358 cso30:c:InputInhibitor connector
c356 cso30:c:OutputProcess connector
IFNAR1_enti_MO000007545
IFNAR1
IFNAR1:Tyk2:IFNAR2:Jak1_enti_MO000038483
IFNAR1:Tyk2:IFNAR2:Jak1
IFNAR1:Tyk2_enti_MO000019457
IFNAR1:Tyk2
Tyk2_enti_MO000000148
Tyk2
IFNAR2_enti_MO000007548
IFNAR2
IFNAR2:Jak1_enti_MO000038484
IFNAR2:Jak1
Jak1_enti_MO000000145
Jak1
IFNalpha:IFNAR1:Tyk2:IFNAR2:Jak1_enti_e5
IFNalpha:IFNAR1:Tyk2:IFNAR2:Jak1
IFNalpha_enti_e6
IFNalpha
IFNbeta_enti_MO000016660
IFNbeta
IFNbeta:IFNAR1:Tyk2:IFNAR2:Jak1_enti_e12
IFNbeta:IFNAR1:Tyk2:IFNAR2:Jak1
STAT1_enti_MO000013119
STAT1
STAT1{p}_enti_MO000019704
STAT1{p}
STAT2{pY}_enti_MO000016849
STAT2{pY}
STAT2_enti_MO000013120
STAT2
STAT2{pY}:STAT1{pY}_enti_MO000016845
STAT2{pY}:STAT1{pY}
IRF9_enti_e11
IRF9
STAT1{p}:STAT2{p}:IRF9_enti_e13
STAT1{p}:STAT2{p}:IRF9
ISRE_enti_e14
ISRE
ISRE:STAT1{p}:STAT2{p}:IRF9_enti_e15
ISRE:STAT1{p}:STAT2{p}:IRF9
IFN inducible genes_enti_e16
IFN inducible genes
IFNGR1_enti_MO000016835
IFNGR1
IFNGR1:Jak1_enti_MO000019460
IFNGR1:Jak1
IFNGR2_enti_MO000007500
IFNGR2
Jak2_enti_MO000000146
Jak2
IFNGR2:Jak2_enti_e17
IFNGR2:Jak2
IFNGR1:JAK1:IFNGR2:JAK2_enti_e18
IFNGR1:JAK1:IFNGR2:JAK2
IFNgamma_enti_MO000016665
IFNgamma
IFNGR1:JAK1:IFNGR2:JAK2:IFNgamma_enti_e19
IFNGR1:JAK1:IFNGR2:JAK2:IFNgamma
(STAT1{p})2_enti_e20
(STAT1{p})2
(STAT1{p})2_enti_e21
(STAT1{p})2
GAS_enti_e22
GAS
GAS:(stat1{p})2_enti_e23
GAS:(stat1{p})2
IFNgamma inducible genes_enti_e24
IFNgamma inducible genes
type III IFN:type III IFN receptor_enti_e25
type III IFN:type III IFN receptor
type III IFN receptor_enti_e26
type III IFN receptor
type III IFN_enti_e27
type III IFN
STAT3{p}_enti_MO000021607
STAT3{p}
STAT3_enti_MO000013122
STAT3
STAT4_enti_MO000017181
STAT4
STAT4{pY}_enti_MO000033720
STAT4{pY}
STAT5_enti_MO000016876
STAT5
STAT5{pY}_enti_MO000032346
STAT5{pY}
p38alpha{p}_enti_MO000038368
p38alpha{p}
p38alpha_enti_MO000016958
p38alpha
PI3K_enti_MO000000030
PI3K
PI3K{active}_enti_e28
PI3K{active}
AKT_enti_MO000000048
AKT
AKT_enti_e29
AKT
mTOR_enti_MO000017140
mTOR
mTOR_enti_e30
mTOR
C/EBPbeta_enti_MO000016580
C/EBPbeta
C/EBPbeta_enti_e31
C/EBPbeta
IL-6_enti_MO000007384
IL-6
IL-1_enti_e32
IL-1
IL8_enti_e33
IL8
TNF-alpha_enti_G010329
TNF-alpha
G-CSF_enti_G010291
G-CSF
CRP_enti_e34
CRP
alpha2-microglobulin_enti_e35
alpha2-microglobulin
α1-acid glycoprotein_enti_e36
α1-acid glycoprotein
C/EBPbeta:STAT3_enti_e37
C/EBPbeta:STAT3
NF-kappaB_enti_MO000000058
NF-kappaB
C/EBPbeta:NF-kappaB_enti_e38
C/EBPbeta:NF-kappaB
Sp1_enti_MO000033284
Sp1
C/EBPbeta:SP1_enti_e39
C/EBPbeta:SP1
pRb_enti_MO000011894
pRb
C/EBPbeta:pRb_enti_e40
C/EBPbeta:pRb
LIP_enti_e41
LIP
C/EBPbeta:LIP_enti_e42
C/EBPbeta:LIP
C/EBPalpha_enti_MO000019417
C/EBPalpha
C/EBPzeta_enti_e43
C/EBPzeta
C/EBPzeta:C/ebpbeta_enti_e44
C/EBPzeta:C/ebpbeta
C/EBPzeta:C/EBPalpha_enti_e45
C/EBPzeta:C/EBPalpha
C/EBPbeta_enti_G010787
C/EBPbeta
LPS_enti_MO000042409
LPS
glucagon_enti_MO000006031
glucagon
IL-1_enti_MO000000214
IL-1
Dexamethasone_enti_e46
Dexamethasone
C?EBPbeta{p}_enti_e47
C?EBPbeta{p}
PKC_enti_MO000000104
PKC
GATE_enti_e48
GATE
C/EBPbeta:GATE_enti_e49
C/EBPbeta:GATE
ERK_enti_MO000000011
ERK
RSK_enti_MO000000051
RSK
PKA_enti_e63
PKA
PU.1_enti_MO000037579
PU.1
pu.1:C/EBPbeta_enti_e64
pu.1:C/EBPbeta
c-Myb_enti_MO000009617
c-Myb
C/EBPbeta:c-myb_enti_e65
C/EBPbeta:c-myb
IRF9_enti_e66
IRF9
2-5A synthatase_enti_e67
2-5A synthatase
MHC I_enti_e68
MHC I
growth factor_enti_e70
growth factor
growth factor:growth factor receptor_enti_e71
growth factor:growth factor receptor
growth factor receptor_enti_e72
growth factor receptor
Grb-2_enti_MO000000012
Grb-2
Sos_enti_MO000016777
Sos
growth factor:growth factor receptor:GRB2:SOS_enti_e73
growth factor:growth factor receptor:GRB2:SOS
Ras family_enti_MO000000003
Ras family
Ras family_enti_e74
Ras family
Raf_enti_MO000000009
Raf
Raf_enti_e75
Raf
MEK1_enti_MO000000078
MEK1
MEK1{p}_enti_MO000038670
MEK1{p}
ERK1{p}_enti_MO000038672
ERK1{p}
ERK1_enti_MO000004670
ERK1
ERK2_enti_MO000004676
ERK2
ERK2{p}_enti_MO000038692
ERK2{p}
Elk-1_enti_MO000000038
Elk-1
Elk-1{p}_enti_MO000038364
Elk-1{p}
c-Jun_enti_MO000000049
c-Jun
c-Jun{p}_enti_MO000038589
c-Jun{p}
c-Fos_enti_MO000000279
c-Fos
c-fos{p}_enti_e76
c-fos{p}
Egr-1_enti_MO000017190
Egr-1
Egr-1{p}_enti_e77
Egr-1{p}
Rho_enti_MO000017369
Rho
Rho{active}_enti_e69
Rho{active}
TNF-alpha_enti_MO000000289
TNF-alpha
Rac_enti_MO000000057
Rac
Rac_enti_e78
Rac
MEKKs_enti_MO000000060
MEKKs
MEKKs{active}_enti_e79
MEKKs{active}
MKK4_enti_MO000016917
MKK4
MKK4{active}_enti_e80
MKK4{active}
SEK2{active}_enti_e81
SEK2{active}
SEK2_enti_e82
SEK2
JNK_enti_MO000000023
JNK
JNK_enti_e83
JNK
p38beta_enti_MO000016959
p38beta
p38beta{p}_enti_MO000038382
p38beta{p}
p38gamma_enti_MO000004690
p38gamma
p38gamma{p}_enti_MO000042106
p38gamma{p}
p38delta_enti_MO000016961
p38delta
p38delta{p}_enti_MO000042108
p38delta{p}
MEKK1_enti_MO000000047
MEKK1
MEKK1{active}_enti_e84
MEKK1{active}
ERK_enti_e85
ERK
MEKK1:MEk1:ERK1:ERK2_enti_e86
MEKK1:MEk1:ERK1:ERK2
NF-kappaB{active}_enti_e87
NF-kappaB{active}
IFN-beta_enti_e88
IFN-beta
transcription mediator complex_enti_e89
transcription mediator complex
C/EBPbeta:transcription mediator complex_enti_e90
C/EBPbeta:transcription mediator complex
GATE:GBF1_enti_e91
GATE:GBF1
GBF1_enti_e92
GBF1
CrkL_enti_MO000016878
CrkL
CrkL{pY}_enti_MO000080026
CrkL{pY}
C/EBPbeta{p}:GBF1_enti_e93
C/EBPbeta{p}:GBF1
IRF9_enti_e94
IRF9
C/EBPbeta:GBF1:IRF9_enti_e95
C/EBPbeta:GBF1:IRF9
Cdc42_enti_MO000000021
Cdc42
MLKs:Cdc42_enti_e96
MLKs:Cdc42
MLKs_enti_e97
MLKs
(MLKs)2:Cdc42_enti_e98
(MLKs)2:Cdc42
(MLKs{p})2:Cdc42_enti_e99
(MLKs{p})2:Cdc42
p38_enti_MO000000022
p38
p38_enti_e100
p38
MLK3_enti_MO000016913
MLK3
Cdk2_enti_MO000017545
Cdk2