1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18251777.csml convertedTime:2009.07.01.11:15

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Macrophage differentiation and function in health and disease.
Authors Naito M.
Affiliation Division of Cellular and Molecular Pathology, Department of Cellular Function,Niigata University Graduate School of Medical and Dental Sciences, Niigata,Japan. mnaito@med.niigata-u.ac.jp
Abstract Macrophages exist in almost all animals. In some invertebrates, mesenchymalcells, endothelial cells or fibroblast-like cells can transform intomacrophages. In vertebrates, primitive macrophages first develop in yolk sachematopoiesis and differentiate into fetal macrophages. Monocytes aredifferentiated from hematopoietic stem cells in the late stage of fetalhematopoietic organs and bone marrow. Macrophages serve as an effector inmetabolism and host defense. Depletion of macrophages severely reduced bilirubinproduction and host resistance to infection. Macrophage scavenger receptors areinvolved in host defense. Macrophage growth factors are critical for macrophagedifferentiation and function. In macrophage colony-stimulating factor(M-CSF)-deficient osteopetrotic mice, monocytes, tissue macrophages andosteoclasts are deficient. Granulocyte-macrophage colony-stimulating factor(GM-CSF)-deficient mice develop alveolar proteinosis due to impaired surfactantcatabolism by alveolar macrophages. Accumulation of glucocerebroside inmacrophages due to the deficiency of glucocerebrosidase in lysosomes producesGaucher cells. Macrophages in the arterial wall incorporate chemically modifiedlow-density lipoprotein (LDL) and transform into foam cells. Binding oxidizedLDL to liver X receptor alpha (LXRalpha) upregulates the expression of itstarget genes, which act as cholesterol removers from macrophages. Inflammatorysignals downregulate the expression of LXRalpha and enhance lipid accumulation.Thus, macrophages play a pivotal role in metabolism and host defense.
PMID 18251777
Model Abstract

Entity

G010389:IL-1beta G010420:SR G011389:CD14 G012162:PU-1 G013072:ABCA1 MO000000058:NF-kappaB MO000000084:M-CSFR MO000000100:M-CSF MO000016882:LPS MO000017464:RXR MO000017793:Modified lipoprotein MO000018132:CD14 MO000019387:cytokines MO000021946:HO-1 MO000042355:MARCO MO000056221:cholesterol MO000064543:CR3 MO000101883:bilirubin MO000107436:oxLDL MO000116148:MSR-A e1: e10: e11:Non-heme protein e12:GM-CSF: GM-CSFR e13:cytokine e14:MSR-A e15:InlA R e16:Listeria ligand e17:Listeria ligand: CR3 e18:Modified lipoprotein: MARCO e19:Scavenger receptor e2: e20:LPS: MSR-A e21:LPS: CD14 e22:lipoteichoic acid e23:lipoteichoic acid: MSR-A e24:Modified lipoprotein: MSR-A e25:oxLDL: Scavenger receptor e26:LXRalpha e27:mannose receptor e28:Cerezyme e29:Cerezyme: mannose receptor e3: e30:LXR e31:e31 e32:LXR {activated}: RXR e33:hormone response element e34:hormone response element: LXR {activated}: RXR e35:oxysterol e36:LXR {activated} e37:ABCA1 e38:poly I:C e39:lipid A e4: e40:synthetic LXR agonist e41:zymosan e42:LPS: TLR4 e43:NF-kappaB {activated} e44:cholesterol removing genes e45:Listeria ligand: InlA R e5:lipo-MDP e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:M-CSF: M-CSFR e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p4 p5 p6 p7 p8 p9
Model Detail
426.0, 965.0
30.0, 30.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p21

--

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
607.0, 1033.0
31.0, 31.0

SR

--

G010420

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p22 p23

--

true true true true

csml-variable:Double

m93392

10

false

infinite

0

unit false false false
TRANSFACG010420

--

Go back
531.0, 946.0
35.0, 35.0

CD14

--

G011389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p10

--

true true true true

csml-variable:Double

m94268

10

false

infinite

0

unit false false false
TRANSFACG011389

--

Go back
584.0, 951.0
34.0, 34.0

PU-1

--

G012162

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p7

p8

true true true true

csml-variable:Double

m94961

10

false

infinite

0

unit false false false
TRANSFACG012162

--

Go back
409.0, 1061.0
30.0, 30.0

ABCA1

--

G013072

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m95583

10

false

infinite

0

unit false false false
TRANSFACG013072

--

Go back
370.0, 626.0
36.0, 36.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
881.0, 999.0
36.0, 36.0

M-CSFR

--

MO000000084

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHMO000000084

--

Go back
977.0, 999.0
32.0, 32.0

M-CSF

--

MO000000100

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m89

10

false

infinite

0

unit false false false
InterProIPR008001
TRANSPATHMO000000100

--

Go back
974.0, 669.0
30.0, 30.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
591.0, 1190.0
28.0, 28.0

RXR

--

MO000017464

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m2283

10

false

infinite

0

unit false false false
TRANSPATHMO000017464

--

Go back
1046.0, 461.0
30.0, 30.0

Modified lipoprotein

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p15

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
885.0, 784.0
31.0, 31.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
383.0, 739.0
34.0, 34.0

cytokines

--

MO000019387

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

--

true true true true

csml-variable:Double

m3957

10

false

infinite

0

unit false false false
TRANSPATHMO000019387

--

Go back
270.0, 466.0
32.0, 32.0

HO-1

--

MO000021946

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m6272

10

false

infinite

0

unit false false false
InterProIPR002051
TRANSPATHMO000021946

--

Go back
887.0, 406.0
28.0, 28.0

MARCO

--

MO000042355

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m20155

10

false

infinite

0

unit false false false
TRANSPATHMO000042355

--

Go back
810.0, 1245.0
30.0, 30.0

cholesterol

--

MO000056221

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m360460

10

false

infinite

0

unit false false false
TRANSPATHMO000056221

--

Go back
892.0, 248.0
31.0, 31.0

CR3

--

MO000064543

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m39415

10

false

infinite

0

unit false false false
TRANSPATHMO000064543

--

Go back
341.0, 533.0
33.0, 33.0

bilirubin

--

MO000101883

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

--

true true true true

csml-variable:Double

m74857

10

false

infinite

0

unit false false false
TRANSPATHMO000101883

--

Go back
1046.0, 1147.0
30.0, 30.0

oxLDL

--

MO000107436

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m341431

10

false

infinite

0

unit false false false
TRANSPATHMO000107436

--

Go back
886.0, 601.0
30.0, 30.0

MSR-A

--

MO000116148

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p18 p19

true true true true

csml-variable:Double

m359003

10

false

infinite

0

unit false false false
Affymetrix208422_at
EnsemblENSG00000038945
HGNCMSR1
InterProIPR003543
OMIM153622
PIRA38415
PROSITEPS00420
ProteomeHumanPSD/MSR1
RefSeqNM_002445
TRANSPATHMO000116148
UnigeneHs.147635
UniProtP21757

--

Go back
184.99611744512623, 112.24708645934633
751.0133137313265, 1235.0385156179798

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
192.2320784315888, 131.12407829281648
727.9618811698118, 1159.7975422973202

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
267.5, 607.125
36.24572348561079, 22.351529482793318

Non-heme protein

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
882.625, 869.5
36.75, 45.0

GM-CSF: GM-CSFR

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p6 p7 p12 p13 p22

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
381.5, 930.0
37.110726643598625, 19.792387543252595

cytokine

--

e13

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
467.0, 966.0
36.0, 36.0

MSR-A

--

e14

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p11

--

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
Affymetrix1425434_a_at
EnsemblENSMUSG00000025044
MGDMsr1
ProteomeHumanPSD/Msr1
RefSeqNM_031195
TRANSFACG006438
UnigeneMm.1227

--

Go back
891.5, 127.0
33.08260105448154, 50.89630931458699

InlA R

--

e15

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p37

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1005.5, 251.375
37.9701230228471, 24.680579964850615

Listeria ligand

--

e16

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p14 p37

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
885.875, 286.5
36.10887318774087, 50.38447421545238

Listeria ligand: CR3

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
885.625, 357.5
29.8993084485919, 36.61139810031661

Modified lipoprotein: MARCO

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
886.375, 1139.5
29.25, 45.0

Scavenger receptor

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p24

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
184.99611744512623, 112.24708645934633
751.0133137313265, 1235.0385156179798

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
885.625, 645.5
30.609690051658056, 37.481253124479245

LPS: MSR-A

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
886.625, 729.5
37.46038160306616, 45.86985502416263

LPS: CD14

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1038.5, 515.25
45.0, 25.5

lipoteichoic acid

--

e22

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p18

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
885.625, 509.5
31.00979003499417, 37.97117147142143

lipoteichoic acid: MSR-A

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
883.625, 454.5
34.48004499250125, 42.22046325612398

Modified lipoprotein: MSR-A

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
889.375, 1199.5
23.25, 45.0

oxLDL: Scavenger receptor

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
583.5, 1082.0
37.110726643598625, 19.792387543252595

LXRalpha

--

e26

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p26 p33

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
750.375, 1293.5
29.25, 45.0

mannose receptor

--

e27

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p27

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
742.5, 1383.25
45.0, 25.5

Cerezyme

--

e28

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p27

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
673.375, 1301.5
23.25, 45.0

Cerezyme: mannose receptor

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p27

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
200.01638371975275, 129.25863626124695
720.9727811820735, 1201.0154160141797

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
689.375, 1136.5
20.63664323374341, 31.748681898066778

LXR

--

e30

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p31

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
653.5, 1244.5
30.0, 30.0

e31

--

e31

cso30:c:ObjectUnknown

cso30:i:CC_Cytosol

--

p28

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
524.875, 1193.5
26.22100385391815, 36.58744723802533

LXR {activated}: RXR

--

e32

cso30:c:Complex

cso30:i:CC_NuclearOuterMembrane

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
518.5, 1257.125
36.028375930770785, 22.217498490641983

hormone response element

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p30

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
453.375, 1185.5
23.25, 45.0

hormone response element: LXR {activated}: RXR

--

e34

cso30:c:Complex

cso30:i:CC_NuclearEnvelopeLumen

--

p30

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
826.5, 1211.25
45.0, 25.5

oxysterol

--

e35

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
632.375, 1168.5
25.48022847100176, 39.20035149384886

LXR {activated}

--

e36

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
300.125, 1109.5
22.627037633326626, 36.69249345944858

ABCA1

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

p32

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
108.5, 1053.25
45.0, 25.5

poly I:C

--

e38

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p32

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
112.5, 977.25
45.0, 25.5

lipid A

--

e39

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p32

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
227.8038763278119, 159.02884841457274
665.3977959659555, 1141.474991707527

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
108.5, 1017.25
45.0, 25.5

synthetic LXR agonist

--

e40

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p32 p35

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
110.5, 915.25
45.0, 25.5

zymosan

--

e41

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p33

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
200.625, 669.5
29.8993084485919, 36.61139810031661

LPS: TLR4

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p34

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
342.0, 670.0
36.0, 36.0

NF-kappaB {activated}

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
569.5, 1122.0
37.88927335640139, 20.207612456747405

cholesterol removing genes

--

e44

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p36

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
896.375, 189.5
23.25, 45.0

Listeria ligand: InlA R

--

e45

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p37

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
90.5, 770.25
45.0, 25.5

lipo-MDP

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p1 p2

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
343.0909014220812, 808.5984828057017
408.4152420506428, 419.4912111203788

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
387.20278976274636, 818.5398146649576
238.81263687877447, 406.57053726656835

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
348.4147500149201, 814.1974414756862
397.7675448649652, 408.29329378040967

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
349.1752998138971, 815.0588197326068
396.24644526701104, 406.57053726656835

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
343.0909014220812, 808.5984828057017
408.4152420506428, 419.4912111203788

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
343.0909014220812, 808.5984828057017
408.4152420506428, 419.4912111203788

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
349.1752998138971, 815.0588197326068
396.24644526701104, 406.57053726656835

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
641.2264226210605, 980.8741341898408
25.515540284112884, 26.160489374699953

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
574.2980403110856, 1101.467090158738
72.25223090281389, 74.07853009517987

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
343.0909014220812, 808.5984828057017
408.4152420506428, 419.4912111203788

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
886.625, 1051.5
34.48004499250125, 42.22046325612398

M-CSF: M-CSFR

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
439.3520759790251, 995.0169107431846
12.933910612582821, 7.0530293721855

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
438.9201760931817, 973.9831081344752
44.26973829894356, 90.24968793737017

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
457.49187118444615, 1032.6820921587812
6.910398173493622, 7.826531203240769

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
194.86333697212063, 117.216979079942
736.5100835709404, 1181.9711596119098

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
197.4945955126525, 138.0776278992537
706.5428992546343, 1161.9070894767676

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
204.51128495407073, 158.93827671856545
703.3171433564563, 1146.668969145853

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
259.0, 768.0
31.0, 31.0

p1

p1

cso30:i:ME_DNACleavage

cso30:i:CC_NuclearChromosome

--

e5

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 18251777 Macrophages incubated in medium containing lipo-MDP increased DNA fragmentation.

Go back
534.0, 885.0
27.0, 27.0

p10

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c14 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 18251777 After LPS administration cytokine production and the expression of LPS receptors, such as CD14 and macrophage scavenger receptor class A (MSR-A), were induced at lower levels in op/op mice than in littermate mice, indicating that deficient macrophage activation following LPS injection in op/op mice is associated with the decreased expression of CD14 and MSR-A in the liver.

Go back
472.0, 891.0
25.0, 25.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c19 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 18251777 After LPS administration cytokine production and the expression of LPS receptors, such as CD14 and macrophage scavenger receptor class A (MSR-A), were induced at lower levels in op/op mice than in littermate mice, indicating that deficient macrophage activation following LPS injection in op/op mice is associated with the decreased expression of CD14 and MSR-A in the liver.

Go back
977.0, 873.0
30.0, 30.0

p12

p12

cso30:i:CE_CellSurvival_InhibitionOfApoptosis_

cso30:i:CC_Cytosol

--

e12

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 18251777 GM-CSF is also a hematopoietic growth factor that stimulates the survival, proliferation, differentiation, and function of myeloid cells and their precursors, particularly neutrophils and monocyte/macrophages.

Go back
978.0, 817.0
30.0, 30.0

p13

p13

cso30:i:CE_CellProliferation

cso30:i:CC_Extracellular

--

e12

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 18251777 GM-CSF is also a hematopoietic growth factor that stimulates the survival, proliferation, differentiation, and function of myeloid cells and their precursors, particularly neutrophils and monocyte/macrophages.

Go back
1010.0, 298.0
27.0, 27.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m16*m39415*0.1

nodelay

--

true

0

false

PMID: 18251777 Complement receptor type 3 (CR3) and the receptor of internalin A (InlA) mediate the uptake of Listeria.

Go back
971.0, 406.0
27.0, 27.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c45 : 1

m20155*m2549*0.1

nodelay

--

true

0

false

PMID: 18251777, 7867067 A class A type III macrophage receptor with a collagenous structure (MARCO) is a trimeric membrane glycoprotein mediating the uptake of chemically modified low-density lipoproteins.

Go back
977.0, 604.0
23.0, 23.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m155666*m359003*0.1

nodelay

--

true

0

false

PMID: 18251777 Type I and type II MSR-A recognize a variety of polyanions such as chemically modified lipoproteins, LPS of Gramnegative bacteria, and lipoteichoic acid of Gram-positive bacteria, suggesting a role in host defense. PMID: 18251777 LPS is known to bind to several receptors on macrophages, including CD14 and MSR-A, and stimulates macrophages to release various nflammatory mediators.

Go back
976.0, 739.0
25.0, 25.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m2828*m155666*0.1

nodelay

--

true

0

false

PMID: 18251777 LPS is known to bind to several receptors on macrophages, including CD14 and MSR-A, and stimulates macrophages to release various nflammatory mediators.

Go back
971.0, 514.0
27.0, 27.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m359003*m22*0.1

nodelay

--

true

0

false

PMID: 18251777 Type I and type II MSR-A recognize a variety of polyanions such as chemically modified lipoproteins, LPS of Gramnegative bacteria, and lipoteichoic acid of Gram-positive bacteria, suggesting a role in host defense.

Go back
971.0, 462.0
28.0, 28.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m359003*m2549*0.1

nodelay

--

true

0

false

PMID: 18251777 Type I and type II MSR-A recognize a variety of polyanions such as chemically modified lipoproteins, LPS of Gramnegative bacteria, and lipoteichoic acid of Gram-positive bacteria, suggesting a role in host defense.

Go back
98.0, 832.0
30.0, 30.0

p2

p2

cso30:i:CE_CellDeath

cso30:i:CC_Extracellular

--

e5

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 18251777 These results imply that the intralysosomal accumulation of MDP generates signals to induce macrophage apoptosis.

Go back
427.0, 854.0
27.0, 27.0

p20

p20

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 18251777 LPS-induced expression of cytokines in the liver was similar in MSR-A+/+and MSR-A-/? mice, but levels of IL-1beta expression and serum IL-1beta were lower in MSR-A-/? mice.

Go back
427.0, 894.0
27.0, 27.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 18251777 LPS-induced expression of cytokines in the liver was similar in MSR-A+/+and MSR-A-/? mice, but levels of IL-1beta expression and serum IL-1beta were lower in MSR-A-/? mice.

Go back
677.0, 999.0
27.0, 27.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c46 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 18251777 Expression of scavenger receptors is enhanced by macrophage colony-stimulating factor (M-CSF) and granulocyte?macrophage colony-stimulating factor (GM-CSF).

Go back
677.0, 1035.0
27.0, 27.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c47 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 18251777 Expression of scavenger receptors is enhanced by macrophage colony-stimulating factor (M-CSF) and granulocyte?macrophage colony-stimulating factor (GM-CSF).

Go back
984.0, 1149.0
25.0, 25.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m341431*m19*0.1

nodelay

--

true

0

false

PMID: 18251777 Scavenger receptors uptake oxidized low-density lipoprotein (oxLDL) and intracellular accumulation of cholesterol stimulate LXRalpha.

Go back
886.0, 1253.0
30.0, 30.0

p25

p25

cso30:i:ME_Accumulation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18251777 Scavenger receptors uptake oxidized low-density lipoprotein (oxLDL) and intracellular accumulation of cholesterol stimulate LXRalpha.

Go back
672.0, 1078.0
27.0, 27.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m360460*0.1

nodelay

--

true

0

false

PMID: 18251777 Scavenger receptors uptake oxidized low-density lipoprotein (oxLDL) and intracellular accumulation of cholesterol stimulate LXRalpha.

Go back
672.0, 1383.0
25.0, 25.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m28*m27*0.1

nodelay

--

true

0

false

PMID: 18251777, 14527307 This modified enzyme is endocytosed after it binds to cell-surface mannose receptors and is subsequently delivered to lysosomes where it supplements the defective enzyme.

Go back
714.0, 1245.0
30.0, 30.0

p28

p28

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c59 : 1
stoichiometry:c61 : 1

m360460*m36*0.1

nodelay

--

true

0

false

PMID: 18251777 Liver X receptors (LXR) are also involved in cholesterol metabolism in macrophages.

Go back
591.0, 1246.0
27.0, 27.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m2283*m36*0.1

nodelay

--

true

0

false

PMID: 18251777, 7935418, 7744246 LXR are nuclear receptors initially identified in the liver that form a functional heterodimer with the retinoid X receptor (RXR) to recognize and bind to its hormone response elements.

Go back
271.0, 535.0
30.0, 30.0

p3

p3

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m6272*m11*0.1

nodelay

--

true

0

false

PMID: 18251777 Heme oxygenase 1 (HO-1) in macrophages and hepatocytes plays a key role in bilirubin metabolism. Senescent or denatured erythrocytes incorporated by Kupffer cells and non-heme protein in hepatocytes are a major source of bilirubin.

Go back
464.0, 1255.0
25.0, 25.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m32*m33*0.1

nodelay

--

true

0

false

PMID: 18251777, 7935418, 7744246 LXR are nuclear receptors initially identified in the liver that form a functional heterodimer with the retinoid X receptor (RXR) to recognize and bind to its hormone response elements.

Go back
718.0, 1193.0
29.0, 29.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c70 : 1
stoichiometry:c69 : 1

m30*m35*0.1

nodelay

--

true

0

false

PMID: 18251777, 9794827, 12449021, 12193651 LXR are activated by a number of oxidized derivatives of cholesterol (oxysterols) and promote the synthesis of ABCA1 and other transporters, which reduce intracellular levels of cholesterol and thus protect against atherosclerosis.

Go back
412.0, 1115.0
25.0, 25.0

p32

p32

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c71 : 1

m95583*m36*0.1

nodelay

--

true

0

false

PMID: 18251777, 9794827, 12449021, 12193651 LXR are activated by a number of oxidized derivatives of cholesterol (oxysterols) and promote the synthesis of ABCA1 and other transporters, which reduce intracellular levels of cholesterol and thus protect against atherosclerosis. PMID: 18251777 A potent TLR3 agonist, poly I:C, and a TLR4 agonist, lipid A, selectively inhibit the synthesis of ABCA1 and other cholesterol efflux mediators, when macrophages are stimulated with synthetic LXR agonists.

Go back
498.0, 1078.0
27.0, 27.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c77 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 18251777 We also confirmed that LXRa expression was markedly decreased in the rat liver after zymosan injection and we therefore cultured human monocytes in the presence of LPS or zymosan.

Go back
273.0, 673.0
30.0, 30.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c80 : 1

m43*m42*0.1

nodelay

--

true

0

false

PMID: 18251777, 12524534 LXR agonist inhibits LPS-TLR4 activation of nuclear factor-kappaB target genes, including inflammatory cytokines.

Go back
361.0, 993.0
29.0, 29.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c82 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 18251777, 12524534 LXR agonist inhibits LPS-TLR4 activation of nuclear factor-kappaB target genes, including inflammatory cytokines.

Go back
630.0, 1118.0
27.0, 27.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 18251777 LXRalpha upregulates several target genes that remove cholesterol from macrophages.

Go back
1009.0, 197.0
29.0, 29.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m15*m16*0.1

nodelay

--

true

0

false

PMID: 18251777 Complement receptor type 3 (CR3) and the receptor of internalin A (InlA) mediate the uptake of Listeria.

Go back
981.0, 1058.0
30.0, 30.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c8 : 1

m89*m76*0.1

nodelay

--

true

0

false

PMID: 18251777 The effects of M-CSF are mediated by the M-CSF receptor (M-CSFR), encoded by the c-fms proto-oncogene.

Go back
978.0, 1101.0
30.0, 30.0

p5

p5

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e6

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 18251777, 8426088 These results indicate that the differentiation and maturation of tissue macrophages are mediated by M-CSF, but dendritic cell differentiation is controlled by other factor(s) than M-CSF, most probably by GM-CSF.

Go back
978.0, 909.0
30.0, 30.0

p6

p6

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e12

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 18251777, 8426088 These results indicate that the differentiation and maturation of tissue macrophages are mediated by M-CSF, but dendritic cell differentiation is controlled by other factor(s) than M-CSF, most probably by GM-CSF. PMID: 18251777 GM-CSF is also a hematopoietic growth factor that stimulates the survival, proliferation, differentiation, and function of myeloid cells and their precursors, particularly neutrophils and monocyte/macrophages.

Go back
588.0, 879.0
25.0, 25.0

p7

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 18251777 GM-CSF acts as a stimulator of terminal differentiation of alveolar macrophages, principally through PU.1 expression.

Go back
978.0, 953.0
30.0, 30.0

p8

p8

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

G012162

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1

m94961*0.1

nodelay

--

true

0

false

PMID: 18251777 GM-CSF acts as a stimulator of terminal differentiation of alveolar macrophages, principally through PU.1 expression. PMID: 18251777 Thus, GM-CSF acts as a stimulator of terminal differentiation of alveolar macrophages, principally through PU.1 expression.

Go back
385.0, 801.0
30.0, 30.0

p9

p9

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m155666*m13*0.1

nodelay

--

true

0

false

PMID: 18251777 After LPS administration cytokine production and the expression of LPS receptors, such as CD14 and macrophage scavenger receptor class A (MSR-A), were induced at lower levels in op/op mice than in littermate mice, indicating that deficient macrophage activation following LPS injection in op/op mice is associated with the decreased expression of CD14 and MSR-A in the liver.

Go back
136.0, 783.0

c1

c1

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
919.0, 898.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
621.0, 892.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
601.0, 904.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
618.0, 968.0

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
548.0, 912.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
568.1864644734965, 691.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
422.8042047563959, 687.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
400.0, 781.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.0, 839.0

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
485.0, 916.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
113.0, 796.0

c2

c2

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
504.3331344758482, 691.0

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
919.0, 846.331820639265

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
919.0, 889.2756982067182

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1024.0, 276.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
925.0, 161.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
923.0, 270.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
930.0, 312.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
915.0, 420.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.464060241731, 434.7133772595955

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
989.0, 635.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
286.0, 498.0

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
916.0, 616.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
923.0363475688873, 623.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
916.0, 762.8553499981773

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
989.0, 699.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
932.0, 752.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
915.0, 546.7519070083929

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1006.0, 528.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
925.0, 528.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
910.0, 496.8490306395842

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1007.0, 476.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
286.0, 573.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
926.0, 476.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
461.5821443458292, 689.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
409.9691115068547, 881.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
461.0683123788179, 672.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
441.0, 921.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
923.0765528038824, 387.7312732965925

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.0437687993774, 1020.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
646.0, 1049.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
710.9339946178163, 903.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
711.9478405722103, 1050.9120472787783

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
301.0, 550.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1017.0, 1162.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
916.0, 1162.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
919.7571182498291, 1170.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
847.9531557045557, 1262.8644734461473

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.1041429180026, 1111.1601724872446

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
629.0, 1092.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
705.0, 1396.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
702.6568542494924, 1331.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.0, 1355.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
658.0, 1199.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
994.0, 1031.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
752.0, 1260.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.0, 1260.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
616.869488893521, 1208.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
557.4768835471551, 1225.6957405716873

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
605.0, 1218.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
494.89723312160595, 1224.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.0, 1268.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
470.631634032896, 1238.8318433579009

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
709.0, 1168.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.7907296779343, 1192.8178369248512

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
917.0, 1027.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
754.9254307187624, 1211.0897467238299

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
331.0, 1128.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.0, 1091.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
444.70984017501604, 1133.1350326638506

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
154.0, 1071.0

c74

c74

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
158.0, 1001.0

c75

c75

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
154.0, 1038.0

c76

c76

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
525.0, 1092.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
156.0, 938.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
310.3417769344585, 652.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
929.0, 1073.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
303.0, 688.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
231.0, 688.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
381.0, 957.5536014515662

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
361.0, 706.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
154.0, 1009.3656128566325

c84

c84

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
644.0, 1153.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
615.0, 1132.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1024.0, 234.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
928.0, 212.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
921.0, 1081.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back