1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18262306.csml convertedTime:2009.07.01.11:15

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title TLR9 as a key receptor for the recognition of DNA.
Authors Kumagai Y, Takeuchi O, Akira S.
Affiliation Laboratory of Host Defense, WPI Immunology Frontier Research Center, 3-1Yamada-oka, Suita, Osaka 565-0871, Japan.
Abstract Unmethylated DNA with CpG-motifs is recognized by Toll-like receptor 9 (TLR9)and pleiotropic immune responses are elicited. Macrophages and conventionaldendritic cells (cDCs) produce proinflammatory cytokines to B/K-type CpG-DNA,whereas plasmacytoid DCs induce type I interferons to A/D-type CpG-DNA and DNAviruses. The TLR9 mediated signaling pathway is not only responsible foractivation of innate immune cells, but also for mounting acquired responses.Thus, it has been attempted to exploit TLR9 ligands as a vaccine adjuvant foranti-cancer immunotherapy. Further, TLR9 mediated signaling is implicated in thepathogenesis of autoimmune diseases such as systemic lupus erythematosus.Nevertheless, recent studies revealed that double-stranded DNA can be recognizedby intracellular receptor(s) in a TLR9-independent manner. This review willfocus on the roles of TLR9 in immune responses, and its signaling pathways.
PMID 18262306
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010531:CD40L G010657:IL-12 p40 G010691:CD40 MO000000058:NF-kappaB MO000000077:MAPKs MO000000212:TRAF6 MO000000213:IRAK MO000000248:IKK MO000000276:AP-1 MO000000289:TNF-alpha MO000007384:IL-6 MO000007685:IRF-1 MO000007700:IRF-5 MO000007702:IRF-7 MO000016573:MyD88 MO000016574:TAK1 MO000016882:LPS MO000016922:CD40 MO000017063:IL-15 MO000017265:IL-12 MO000019394:TLR4 MO000019397:TLR2:TLR1 MO000019398:TLR3 MO000022136:Ubc13 MO000022224:dsRNA MO000039077:IRAK-4 MO000041446:dsRNA:TLR3 MO000041457:IRF-7{p} MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000061425:ZBP1 MO000066987:DDX58 MO000103999:IFIH1 e1: e10: e100:IRAK-4 e101:TRAF6 e102:TLR9:CgG DNA:MyD88:IRAK1:IRAK4:TRAF6:IRF-7 e103:TLR9:CgG DNA:MyD88:IRAK1:IRAK4:TRAF6:IRF-7{p} e104:Type I IFN e105:IFN inducible genes e106:TLR9:CpG DNA:MyD88:IRAK1:IRAK4 e107:TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4 e108:TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4:TRAF6 e109:Viral DNA e11: e110:TLR9:Viral DNA e111:Viral RNA e112:DDX58:Viral RNA e113:IFIH1:Viral RNA e114:Type I IFN e115:DNA e116:ZBP1:DNA e12:CpG DNA e13:TLR2:TLR6 e14:microbial Lipoproteins e15:micorbial lipoproteins:TLR2:TLR1 e16:LPS:TLR4 e17:micorbial lipoproteins:TLR2:TLR6 e18:ssRNA e19:TLR7:ssRNA e2: e20:TLR8:ssRNA e21:TLR9:CpGDNA e22:Bacterial DNA e23:TLR9:Bacterial DNA e24:Hemozoin e25:TLR9:hemozoin e26:TLR9:CpG DNA:MyD88 e27:TLR9:CpG DNA:MyD88:IRAK1:IRAK4 e28:TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4 e29:TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4:TRAF6 e3: e30:TAK1{active} e31:IKK{p} e32:NF-KappaB:IKappa-B e33:NF-KappaB:IKappa-B{p} e34:MAPKs{active} e35:degradants e36:NF-kappaB e37:AP-1{p} e38:AP-1{p} e39:IRF-5 e4: e40:TLR9:CpG DNA:MyD88:IRF-5 e41: e42: e43: e44: e45: e46: e47:TLR9 e48:Unc93B e49:TLR9:CpGDNA:Unc93B e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:MHC Class II e64:MHC Class II molecules e65:Co-stimulatory molecules e66:Co-stimulatory molecules e67:IL-15 e68:CD40L e69: e7: e70: e71: e72: e73: e74: e75: e76: e77: e78: e79: e8: e80: e81: e82: e83: e84: e85: e86:TLR9 e87: e88: e89: e9: e90:CD40:CD40L e91:TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4:TRAF6:IRF-1 e92:IRF-1{active} e93: e94: e95: e96:TLR9:CpGDNA e97:MyD88 e98:TLR9:CpG DNA:MyD88 e99:IRAK

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p7 p8 p9
Model Detail
582.0, 1098.0
28.0, 28.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p47

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
373.0, 1281.0
22.0, 22.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p24 p25 p31

p34

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
300.0, 1248.0
24.0, 24.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p22 p23 p30

p33

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
1426.0, 1286.0
28.0, 28.0

CD40L

--

G010531

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m93494

10

false

infinite

0

unit false false false
TRANSFACG010531

--

Go back
505.0, 1285.0
29.0, 29.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p26 p27 p32

p35 p44

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
677.0, 1169.0
30.0, 30.0

CD40

--

G010691

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m93612

10

false

infinite

0

unit false false false
TRANSFACG010691

--

Go back
389.0, 1097.0
22.0, 22.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

p22 p24 p26

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
680.0, 844.0
24.0, 24.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
507.0, 579.0
18.0, 18.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1030.0, 802.0
20.0, 20.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
474.0, 702.0
20.0, 20.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
485.0, 893.0
21.0, 21.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
55.0, 1123.0
18.0, 18.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
42.0, 1398.0
20.0, 20.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
465.0, 501.0
22.0, 22.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
882.0, 826.0
20.0, 20.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
1596.0, 1048.0
24.0, 24.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1074.0, 758.0
19.0, 19.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
533.0, 653.0
29.0, 29.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
47.0, 203.0
18.0, 18.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1129.0, 1153.0
22.0, 22.0

CD40

--

MO000016922

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

p43

true true true true

csml-variable:Double

m1837

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000016922

--

Go back
1219.0, 1567.0
18.0, 18.0

IL-15

--

MO000017063

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

p41

true true true true

csml-variable:Double

m1956

10

false

infinite

0

unit false false false
InterProIPR003443
TRANSPATHMO000017063

--

Go back
33.0, 1477.0
21.0, 21.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35 p44

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
126.0, 202.0
20.0, 20.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
800.0, 132.0
23.0, 23.0

TLR2:TLR1

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
922.0, 418.0
19.0, 19.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
695.0, 763.0
18.0, 18.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
1212.0, 416.0
23.0, 23.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1018.0, 850.0
20.0, 20.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
949.0, 461.0
21.0, 21.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4

--

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
1477.0, 1197.0
30.0, 30.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

p53 p54

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
918.0, 342.0
20.0, 20.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
983.0, 503.0
17.0, 17.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

p7 p8 p9 p58

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
819.0, 299.0
18.0, 18.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
881.0, 1401.0
22.0, 22.0

ZBP1

--

MO000061425

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p63

true true true true

csml-variable:Double

m36323

10

false

infinite

0

unit false false false
TRANSPATHMO000061425

--

Go back
229.0, 441.0
22.0, 22.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
393.0, 457.0
22.0, 22.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
96.33985816021087, 101.74113228849944
1089.0021405661043, 1581.231108101981

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
95.83231795983787, 125.9095175955232
1055.576555501729, 1484.8994017511322

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1570.0, 874.0
20.0, 20.0

IRAK-4

--

e100

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m102

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
1583.0, 971.0
18.0, 18.0

TRAF6

--

e101

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m103

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1381.0, 1050.0
21.0, 35.00000000000001

TLR9:CgG DNA:MyD88:IRAK1:IRAK4:TRAF6:IRF-7

--

e102

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p51

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1333.0, 1090.0
21.0, 35.00000000000001

TLR9:CgG DNA:MyD88:IRAK1:IRAK4:TRAF6:IRF-7{p}

--

e103

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p52

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
1562.0, 1284.0
50.034602076124564, 26.68512110726644

Type I IFN

--

e104

cso30:c:mRNA

cso30:i:CC_NuclearBody

--

p53

--

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
1519.0, 1391.0
50.034602076124564, 26.68512110726644

IFN inducible genes

--

e105

cso30:c:mRNA

cso30:i:CC_NuclearBody

--

p54

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
1445.0, 926.0
21.0, 35.00000000000001

TLR9:CpG DNA:MyD88:IRAK1:IRAK4

--

e106

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

p56

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
1453.0, 982.0
21.0, 35.00000000000001

TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4

--

e107

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

p57

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
1433.0, 1022.0
21.0, 35.00000000000001

TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4:TRAF6

--

e108

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52 p57

p50

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
1210.0, 341.5
60.0, 13.0

Viral DNA

--

e109

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p58

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
713.2777767242522, 255.0569662260823
293.0990840650066, 489.32643695598557

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
803.5, 251.0
17.936636702477525, 34.71607103705328

TLR9:Viral DNA

--

e110

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p58

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
309.0, 428.5
45.73996930497698, 23.632317474238107

Viral RNA

--

e111

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p59 p60

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
252.0, 535.0
23.121546961325965, 25.69060773480663

DDX58:Viral RNA

--

e112

cso30:c:Complex

cso30:i:CC_Cytosol

--

p59

p62

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
240.0, 619.0
23.121546961325965, 25.69060773480663

IFIH1:Viral RNA

--

e113

cso30:c:Complex

cso30:i:CC_Cytosol

--

p60

p61

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
679.0, 1351.0
50.034602076124564, 26.68512110726644

Type I IFN

--

e114

cso30:c:mRNA

cso30:i:CC_NuclearBody

--

p61 p62

--

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
1002.0, 1465.5
60.0, 13.0

DNA

--

e115

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p63

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
858.4736436101826, 1474.5341990228849
67.03522756492674, 18.993314476729235

ZBP1:DNA

--

e116

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63

--

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
1194.0, 504.0
60.0, 16.0

CpG DNA

--

e12

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p7 p36 p48

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
608.0, 136.0
23.0, 23.0

TLR2:TLR6

--

e13

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
732.0, 56.5
24.428822495606333, 15.878734622144112

microbial Lipoproteins

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1 p3

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
881.5, 117.0
21.401358047348147, 29.862360066067186

micorbial lipoproteins:TLR2:TLR1

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
131.5, 247.0
17.827888620916465, 34.505590879193164

LPS:TLR4

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
657.5, 117.0
21.401358047348147, 29.862360066067186

micorbial lipoproteins:TLR2:TLR6

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
941.0, 78.5
37.92589344442008, 19.595044946283707

ssRNA

--

e18

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p5 p6

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
864.5, 329.0
15.564569173426879, 30.124972593729446

TLR7:ssRNA

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
96.33985816021087, 101.74113228849944
1089.0021405661043, 1581.231108101981

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
948.5, 385.0
15.564569173426879, 30.124972593729446

TLR8:ssRNA

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
971.5, 551.0
17.882262661697, 34.610830958123216

TLR9:CpGDNA

--

e21

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p7

p10 p37 p38 p39 p40 p42

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1206.0, 569.5
60.0, 13.0

Bacterial DNA

--

e22

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
954.5, 615.0
18.065775049331286, 34.96601622451217

TLR9:Bacterial DNA

--

e23

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p8

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1228.0, 641.0
40.4457527333894, 22.919259882253996

Hemozoin

--

e24

cso30:c:SmallMolecule

cso30:i:CC_EndosomeLumen

--

--

p9

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
910.5, 639.0
18.01819776364832, 34.87393115544837

TLR9:hemozoin

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
880.5, 688.0
22.96384657735364, 32.04257661956322

TLR9:CpG DNA:MyD88

--

e26

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p10 p29

p11 p28

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
729.0, 478.0
21.0, 35.00000000000001

TLR9:CpG DNA:MyD88:IRAK1:IRAK4

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p12

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
721.0, 554.0
21.0, 35.00000000000001

TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p13

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
717.0, 622.0
21.0, 35.00000000000001

TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4:TRAF6

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13 p46

p14 p45

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
118.1199009715329, 123.52117509982156
1045.4420549434594, 1537.6710224793387

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
621.0, 741.0
29.0, 29.0

TAK1{active}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

p15 p18

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
482.0, 758.0
20.0, 20.0

IKK{p}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

p16

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
403.5, 729.0
17.490084985835697, 21.416430594900845

NF-KappaB:IKappa-B

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
267.5, 793.0
17.490084985835697, 21.416430594900845

NF-KappaB:IKappa-B{p}

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p19

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
496.0, 820.0
24.0, 24.0

MAPKs{active}

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

p20

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
241.0, 861.0
21.883974727168294, 21.154508902929347

degradants

--

e35

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
325.0, 1009.0
22.0, 22.0

NF-kappaB

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19

p17

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
565.0, 969.0
21.0, 21.0

AP-1{p}

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

p21

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
501.0, 1093.0
21.0, 21.0

AP-1{p}

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

p23 p25 p27

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
610.0, 1190.0
20.0, 20.0

IRF-5

--

e39

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

p30 p31 p32

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
158.41298017247908, 161.6362500196349
964.8558965415683, 1461.44087263971

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
794.0, 712.0
19.147058823529413, 31.911764705882355

TLR9:CpG DNA:MyD88:IRF-5

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

p29

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
214.2158999403166, 273.25
308.22313536762334, 93.16069043265803

--

e41

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

--

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false true false

--

Go back
219.66679140180187, 278.7008914614853
297.32135244465303, 82.25890750968736

--

e42

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulumLumen

--

--

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false true false

--

Go back
217.1891134647631, 276.2232135244465
302.2767083187305, 87.2142633837649

--

e43

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum

--

--

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false true false

--

Go back
218.6757202269863, 277.70982028666987
299.3034947942838, 84.24104985931838

--

e44

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false true false

--

Go back
214.2158999403166, 273.25
308.22313536762334, 93.16069043265803

--

e45

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false true false

--

Go back
214.2158999403166, 273.25
308.22313536762334, 93.16069043265803

--

e46

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false true false

--

Go back
419.0, 307.0
17.0, 17.0

TLR9

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
609.0, 247.5
21.599999999999998, 16.199999999999996

Unc93B

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p37

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
710.5, 311.0
19.097082033400625, 26.647091209396223

TLR9:CpGDNA:Unc93B

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
713.2777767242522, 255.0569662260823
293.0990840650066, 489.32643695598557

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
246.10782524190088, 1024.7258991337915
595.3088893472303, 539.8797562608963

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
310.4056196220487, 1037.5202644954622
348.0949557821796, 523.2510163349951

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
253.8679038739877, 1031.9316864350144
579.7887320830569, 525.4681816584489

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
254.97648653571446, 1033.0402690967421
577.5715667596044, 523.2510163349951

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
246.10782524190088, 1024.7258991337915
595.3088893472303, 539.8797562608963

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
246.10782524190088, 1024.7258991337915
595.3088893472303, 539.8797562608963

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
254.97648653571446, 1033.0402690967421
577.5715667596044, 523.2510163349951

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
680.6722286387629, 1246.4424314791277
37.19162847929725, 33.668211044416466

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
583.1169544068136, 1401.6440041208657
105.31535286403523, 95.33810890849513

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
246.10782524190088, 1024.7258991337915
595.3088893472303, 539.8797562608963

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
713.2777767242522, 255.0569662260823
293.0990840650066, 489.32643695598557

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
386.41878088847875, 1264.6440017529817
18.852557811097295, 9.077157464602404

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
385.7892406194628, 1237.5737701853145
64.52787757409106, 116.15017963336378

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
412.85947218713113, 1313.118602467178
10.072644304248351, 10.07264430424836

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
559.0, 1397.0
42.71626297577855, 22.782006920415228

MHC Class II

--

e63

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p38

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
583.5, 1631.0
16.567719863151538, 26.866572751056538

MHC Class II molecules

--

e64

cso30:c:Protein

cso30:i:CC_Extracellular

--

p38

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
775.0, 1620.0
17.195509822263798, 39.68194574368569

Co-stimulatory molecules

--

e65

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p39

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
442.0, 1432.0
60.0, 32.0

Co-stimulatory molecules

--

e66

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p39

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
733.0, 1220.0
45.57093425605536, 24.304498269896193

IL-15

--

e67

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p40

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1234.5, 1481.0
18.079291607969406, 29.317770175085528

CD40L

--

e68

cso30:c:Protein

cso30:i:CC_Extracellular

--

p41

p43

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1184.139458821579, 733.3338038425669
576.4235683765452, 901.8710058926677

--

e69

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false true false

--

Go back
110.64775788697489, 108.10413126888356
1067.9718227261815, 1513.2884868149572

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1216.9956022190424, 767.4955843688048
510.71128158161906, 833.5474448401926

--

e70

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false true false

--

Go back
1195.66793018911, 745.7562694884716
553.3666256414834, 877.0260746008597

--

e71

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false true false

--

Go back
1184.139458821579, 733.3338038425669
576.4235683765452, 901.8710058926677

--

e72

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false true false

--

Go back
1407.2853292179173, 1294.6999187510664
11.056078400559162, 5.323297007676647

--

e73

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false true false

--

Go back
1422.7914668408346, 1323.1278377264152
5.907100046825618, 5.907100046825625

--

e74

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false true false

--

Go back
1406.9161354649902, 1278.8245873752228
37.84235967497663, 68.11624741495805

--

e75

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false true false

--

Go back
1325.0, 1154.0
349.1187678150766, 316.6123648527793

--

e76

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false true false

--

Go back
1362.707427436265, 1161.5032527650312
204.14021060322906, 306.86044396408977

--

e77

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false true false

--

Go back
1325.0, 1154.0
349.1187678150766, 316.6123648527793

--

e78

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false true false

--

Go back
1329.5508964147214, 1158.2258323850988
340.0169749856333, 308.16070008258185

--

e79

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false true false

--

Go back
114.46319781411205, 134.812210758843
1024.5180952482276, 1487.600274300424

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
1579.850199224413, 1284.0256118491914
21.811022378593954, 19.744714995358777

--

e80

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false true false

--

Go back
1330.2010244739674, 1158.875960444344
338.71671886714125, 306.86044396408977

--

e81

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false true false

--

Go back
1325.0, 1154.0
349.1187678150766, 316.6123648527793

--

e82

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false true false

--

Go back
1330.2010244739674, 1158.875960444344
338.71671886714125, 306.86044396408977

--

e83

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false true false

--

Go back
1522.6389300107699, 1375.0435401436243
61.76216562836545, 55.911013095152036

--

e84

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false true false

--

Go back
1325.0, 1154.0
349.1187678150766, 316.6123648527793

--

e85

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false true false

--

Go back
1287.0, 851.0
17.0, 17.0

TLR9

--

e86

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
1190.5027927664387, 748.7784921203802
472.7819003970547, 739.7134875658022

--

e87

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false true false

--

Go back
1188.7420908833092, 735.4978232693388
492.8343874655094, 752.4870246488013

--

e88

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false true false

--

Go back
1177.097742214758, 774.3516025033666
540.9980201081995, 820.0475797450407

--

e89

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false true false

--

Go back
124.63770428647753, 161.52029024880247
1019.8406081600078, 1468.0907694618757

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1165.5, 1311.0
21.09098483586069, 25.825695717380444

CD40:CD40L

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

p44

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
722.0, 427.0
20.117647058823533, 33.52941176470589

TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4:TRAF6:IRF-1

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

p46

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
753.0, 997.0
22.0, 22.0

IRF-1{active}

--

e92

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46

p47

true true true true

csml-variable:Double

m94

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
1289.0, 824.0
185.63188136461005, 309.9108527866796

--

e93

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false true false

--

Go back
1289.0, 824.0
185.63188136461005, 309.9108527866796

--

e94

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false true false

--

Go back
1289.0, 824.0
185.63188136461005, 309.9108527866796

--

e95

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false true false

--

Go back
1351.5, 827.0
17.882262661697, 34.610830958123216

TLR9:CpGDNA

--

e96

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p48

p49

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1506.0, 790.0
19.0, 19.0

MyD88

--

e97

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m99

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1420.5, 880.0
22.96384657735364, 32.04257661956322

TLR9:CpG DNA:MyD88

--

e98

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p49

p55

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1550.0, 834.0
20.0, 20.0

IRAK

--

e99

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m101

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
822.0, 54.0
20.0, 20.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 MO000019397

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m14*m3964*0.1

nodelay

--

true

0

false

PMID: 18262306,10549626,9851930,10201887 TLR2 (together with TLR1 or TLR6) and TLR4 are the receptors mainly involved in the recognition of bacteria-derived ligands, such as microbial lipoproteins and LPS, respectively

Go back
980.0, 692.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e21

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c28 : 1
stoichiometry:c30 : 1

m1572*m21*0.1

nodelay

--

true

0

false

PMID: 18262306 MyD88, one of these adaptors containing a TIR domain and a death domain (DD), is known to be essential for initiating TLR9 signaling.

Go back
956.0, 736.0
23.0, 23.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 MO000000213 MO000039077

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m26*m184*m17258*0.1

nodelay

--

true

0

false

PMID: 18262306 MyD88 in turn interacts with interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-4 through its DD.

Go back
649.0, 501.0
21.0, 21.0

p12

p12

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 18262306,17485511 IRAK-4 and its kinase activity are shown to be essential for TLR9-mediated cytokine production PMID: 18262306 IRAK-1 is a known substrate of IRAK-4, and phosphorylated IRAK-1 upregulates its kinase activity, and subsequently recruits tumor necrosis factor associated factor 6 (TRAF6).

Go back
587.0, 579.0
17.0, 17.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e28 MO000000212

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m28*m183*0.1

nodelay

--

true

0

false

PMID: 18262306 IRAK-1 is a known substrate of IRAK-4, and phosphorylated IRAK-1 upregulates its kinase activity, and subsequently recruits tumor necrosis factor associated factor 6 (TRAF6).

Go back
627.0, 679.0
17.0, 17.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e29 MO000016574

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m29*m1573*0.1

nodelay

--

true

0

false

PMID: 18262306,11460167 Downstream of TRAF6, transforming growth factor-beta associated kinase 1 (TAK1) is activated to the phosphorylate IKappaB kinase (IKK) complex, which phosphorylates IKappaB to induce nuclear translocation of NF-KappaB

Go back
558.0, 702.0
19.0, 19.0

p15

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e30 MO000000248

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m30*m207*0.1

nodelay

--

true

0

false

PMID: 18262306, 11460167 Downstream of TRAF6, transforming growth factor-beta associated kinase 1 (TAK1) is activated to the phosphorylate IKappaB kinase (IKK) complex, which phosphorylates IKappaB to induce nuclear translocation of NF-KappaB

Go back
370.0, 794.0
19.0, 19.0

p15

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e31 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m31*m32*0.1

nodelay

--

true

0

false

PMID: 18262306, 11460167 Downstream of TRAF6, transforming growth factor-beta associated kinase 1 (TAK1) is activated to the phosphorylate IKappaB kinase (IKK) complex, which phosphorylates IKappaB to induce nuclear translocation of NF-KappaB

Go back
390.0, 1010.0
19.0, 19.0

p17

p17

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e36

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c50 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 18262306, 11460167 Downstream of TRAF6, transforming growth factor-beta associated kinase 1 (TAK1) is activated to the phosphorylate IKappaB kinase (IKK) complex, which phosphorylates I¦ÊB to induce nuclear translocation of NF-KappaB

Go back
610.0, 806.0
19.0, 19.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 MO000000077 MO000022136

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c57 : 1
stoichiometry:c53 : 1

m30*m69*m6443*0.1

nodelay

--

true

0

false

PMID: 18262306 Figure1 PMID: 18262306,16862162,16186825 A study of Ubc13-deificient mice revealed that UBC13 is prerequisite for the activation of mitogen-activated protein (MAP) kinases, but is dispensable for NF-KappaB activation, whereas TAK1 is required for both

Go back
325.0, 861.0
21.0, 21.0

p19

p19

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e33

e35 e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 18262306 Figure1

Go back
46.0, 254.0
19.0, 19.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000019394

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 18262306,10549626,9851930,10201887 TLR2 (together with TLR1 or TLR6) and TLR4 are the receptors mainly involved in the recognition of bacteria-derived ligands, such as microbial lipoproteins and LPS, respectively

Go back
565.0, 893.0
21.0, 21.0

p20

p20

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e34 MO000000276

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m35*m219*0.1

nodelay

--

true

0

false

PMID: 18262306 Figure 1

Go back
489.0, 969.0
21.0, 21.0

p21

p21

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 18262306 Figure 1

Go back
322.0, 1126.0
20.0, 20.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000058

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18262306 Transcription factors NF-KappaB and AP-1 are responsible for the transcription of proinflammatory cytokine genes, including TNF-alpha, IL-6 and IL-12. PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules

Go back
366.0, 1158.0
20.0, 20.0

p22

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e38

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 18262306 Transcription factors NF-KappaB and AP-1 are responsible for the transcription of proinflammatory cytokine genes, including TNF-alpha, IL-6 and IL-12. PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules

Go back
402.0, 1182.0
20.0, 20.0

p22

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000058

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18262306 Transcription factors NF-KappaB and AP-1 are responsible for the transcription of proinflammatory cytokine genes, including TNF-alpha, IL-6 and IL-12. PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules

Go back
486.0, 1178.0
20.0, 20.0

p22

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e38

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 18262306 Transcription factors NF-KappaB and AP-1 are responsible for the transcription of proinflammatory cytokine genes, including TNF-alpha, IL-6 and IL-12. PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules

Go back
450.0, 1166.0
20.0, 20.0

p22

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000058

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18262306 Transcription factors NF-KappaB and AP-1 are responsible for the transcription of proinflammatory cytokine genes, including TNF-alpha, IL-6 and IL-12. PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules

Go back
542.0, 1178.0
20.0, 20.0

p22

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e38

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 18262306 Transcription factors NF-KappaB and AP-1 are responsible for the transcription of proinflammatory cytokine genes, including TNF-alpha, IL-6 and IL-12. PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules

Go back
881.0, 761.0
22.0, 22.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 MO000007700

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m26*m979*0.1

nodelay

--

true

0

false

PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha

Go back
633.0, 989.0
22.0, 22.0

p29

p29

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e40

e39 e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha

Go back
658.0, 54.0
20.0, 20.0

p1

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 e13

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m14*m13*0.1

nodelay

--

true

0

false

PMID: 18262306,10549626,9851930,10201887 TLR2 (together with TLR1 or TLR6) and TLR4 are the receptors mainly involved in the recognition of bacteria-derived ligands, such as microbial lipoproteins and LPS, respectively

Go back
642.0, 1262.0
19.0, 19.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e39

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha

Go back
510.0, 1346.0
19.0, 19.0

p30

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e39

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha

Go back
586.0, 1334.0
19.0, 19.0

p30

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e39

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha

Go back
202.0, 1122.0
19.0, 19.0

p33

p33

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha

Go back
210.0, 1402.0
19.0, 19.0

p33

p34

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010262

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m93248*0.1

nodelay

--

true

0

false

PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha

Go back
238.0, 1478.0
19.0, 19.0

p33

p35

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010657

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m93589*0.1

nodelay

--

true

0

false

PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha

Go back
653.0, 361.0
22.0, 22.0

p36

p36

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e47 e12

MO000042012

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c95 : 1
stoichiometry:c94 : 1

m48*m12*0.1

nodelay

--

true

0

false

PMID: 18262306,14716310 TLR9 is originally localized in the ER, and then migrates to the endosome when the cells are stimulated

Go back
693.0, 245.0
22.0, 22.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 e21

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m49*m21*0.1

nodelay

--

true

0

false

--

Go back
570.0, 1566.0
19.0, 19.0

p38

p38

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e63 e21

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c101 : 1
stoichiometry:c100 : 1

m64*m21*0.1

nodelay

--

true

0

false

PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules

Go back
722.0, 1522.0
19.0, 19.0

p38

p39

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e66 e21

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c104 : 1
stoichiometry:c103 : 1

m67*m21*0.1

nodelay

--

true

0

false

PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules

Go back
1005.0, 397.0
21.0, 21.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 18262306,11607032,14976261,14976262,11812998 TLR3 and 7 (and possibly 8) are involved in the recognition of double-stranded (ds) and single-stranded (ss) RNA, respectively

Go back
869.0, 1221.0
21.0, 21.0

p40

p40

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e67 e21

MO000017063

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c107 : 1
stoichiometry:c106 : 1

m68*m21*0.1

nodelay

--

true

0

false

PMID: 18262306 cDC produces IL-15 upon TLR9 stimulation

Go back
1441.0, 1485.0
21.0, 21.0

p41

p41

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010531 MO000017063

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c109 : 1

m93494*m1956*0.1

nodelay

--

true

0

false

PMID: 18262306 IL-15 in turn activates pDC to express CD40L on its surface.

Go back
949.0, 1165.0
23.0, 23.0

p42

p42

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010691 e21

MO000016922

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c113 : 1
stoichiometry:c112 : 1

m93612*m21*0.1

nodelay

--

true

0

false

PMID: 18262306 At the same time, TLR9 signaling facilitates expression of CD40 on cDC

Go back
1232.0, 1280.0
23.0, 23.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000016922 e68

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m1837*m70*0.1

nodelay

--

true

0

false

PMID: 18262306 Consequently, crosstalk between cDC and pDC via CD40-CD40L ligation leads to production of IL-12 from cDC.

Go back
198.0, 1342.0
19.0, 19.0

p44

p44

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e90 G010657

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c119 : 1
stoichiometry:c118 : 1

m92*m93589*0.1

nodelay

--

true

0

false

PMID: 18262306 Consequently, crosstalk between cDC and pDC via CD40-CD40L ligation leads to production of IL-12 from cDC.

Go back
465.0, 433.0
21.0, 21.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007685 e29

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m970*m29*0.1

nodelay

--

true

0

false

PMID: 18262306,17018642 It was revealed that IRF-1 also interacts with MyD88, and IRF-1, but not IRF-7, and is activated in response to TLR9 stimulation of cDCs to control the expression of IFN-beta

Go back
349.0, 585.0
21.0, 21.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e91

e29 e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m93*0.1

nodelay

--

true

0

false

PMID: 18262306,17018642 It was revealed that IRF-1 also interacts with MyD88, and IRF-1, but not IRF-7, and is activated in response to TLR9 stimulation of cDCs to control the expression of IFN-beta

Go back
673.0, 1101.0
19.0, 19.0

p47

p47

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e92

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m94*0.1

nodelay

--

true

0

false

PMID: 18262306,17018642 It was revealed that IRF-1 also interacts with MyD88, and IRF-1, but not IRF-7, and is activated in response to TLR9 stimulation of cDCs to control the expression of IFN-beta

Go back
1326.0, 698.0
19.0, 19.0

p7

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e86 e12

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m88*m12*0.1

nodelay

--

true

0

false

PMID: 18262306,11130078 TLR9 was first cloned and identified as a receptor for unmethylated CpG-DNA as well as for bacterial DNA in 2000

Go back
1428.0, 816.0
23.0, 23.0

p10

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e97 e96

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m99*m98*0.1

nodelay

--

true

0

false

PMID: 18262306 MyD88, one of these adaptors containing a TIR domain and a death domain (DD), is known to be essential for initiating TLR9 signaling.

Go back
889.0, 241.0
21.0, 21.0

p4

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m19940*m18*0.1

nodelay

--

true

0

false

PMID: 18262306,11607032,14976261,14976262,11812998 TLR3 and 7 (and possibly 8) are involved in the recognition of double-stranded (ds) and single-stranded (ss) RNA, respectively

Go back
1512.0, 1036.0
20.0, 20.0

p11

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007702 e108

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c153 : 1

m980*m110*0.1

nodelay

--

true

0

false

PMID: 18262306,15361868 IRF-7 directly interacts with MyD88 and forms a large complex with IRAK-1, IRAK-4 and TRAF6 in pDCs

Go back
1478.0, 1086.0
19.0, 19.0

p51

p51

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e102

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c141 : 1

m104*0.1

nodelay

--

true

0

false

PMID: 18262306 IRF-7 is phosphorylated in the complex and translocates into the nucleus to induce transcription of type I IFNs and IFN-inducible genes.

Go back
1326.0, 1182.0
19.0, 19.0

p52

p52

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e103

MO000041457 e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c154 : 1

m105*0.1

nodelay

--

true

0

false

PMID: 18262306 IRF-7 is phosphorylated in the complex and translocates into the nucleus to induce transcription of type I IFNs and IFN-inducible genes.

Go back
1558.0, 1230.0
19.0, 19.0

p53

p53

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041457

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 18262306 IRF-7 is phosphorylated in the complex and translocates into the nucleus to induce transcription of type I IFNs and IFN-inducible genes.

Go back
1494.0, 1326.0
19.0, 19.0

p53

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041457

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 18262306 IRF-7 is phosphorylated in the complex and translocates into the nucleus to induce transcription of type I IFNs and IFN-inducible genes.

Go back
1484.0, 852.0
23.0, 23.0

p11

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e99 e100 e98

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m101*m102*m100*0.1

nodelay

--

true

0

false

PMID: 18262306 MyD88 in turn interacts with interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-4 through its DD.

Go back
1517.0, 933.0
21.0, 21.0

p12

p56

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e106

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c140 : 1

m108*0.1

nodelay

--

true

0

false

PMID: 18262306,17485511 IRAK-4 and its kinase activity are shown to be essential for TLR9-mediated cytokine production PMID: 18262306 IRAK-1 is a known substrate of IRAK-4, and phosphorylated IRAK-1 upregulates its kinase activity, and subsequently recruits tumor necrosis factor associated factor 6 (TRAF6).

Go back
1519.0, 991.0
18.0, 18.0

p13

p57

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e107 e101

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1

m109*m103*0.1

nodelay

--

true

0

false

PMID: 18262306 IRAK-1 is a known substrate of IRAK-4, and phosphorylated IRAK-1 upregulates its kinase activity, and subsequently recruits tumor necrosis factor associated factor 6 (TRAF6).

Go back
1066.0, 350.0
19.0, 19.0

p7

p58

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e109 MO000042012

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m111*m19828*0.1

nodelay

--

true

0

false

PMID: 18262306 TLR9 also recognizes bacterial and viral DNA

Go back
286.0, 482.0
19.0, 19.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 e111

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m41844*m113*0.1

nodelay

--

true

0

false

PMID: 18262306,16424890 Nevertheless, recent studies revealed that cytosolic PRRs called Retinoic acid-inducible gene (RIG-I)-like helicases (RLHs) can recognize viral RNA in the cytosol

Go back
989.0, 301.0
21.0, 21.0

p4

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 MO000042007

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m18*m19823*0.1

nodelay

--

true

0

false

PMID: 18262306,11607032,14976261,14976262,11812998 TLR3 and 7 (and possibly 8) are involved in the recognition of double-stranded (ds) and single-stranded (ss) RNA, respectively

Go back
342.0, 522.0
19.0, 19.0

p59

p60

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000103999 e111

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m76904*m113*0.1

nodelay

--

true

0

false

PMID: 18262306,16424890 Nevertheless, recent studies revealed that cytosolic PRRs called Retinoic acid-inducible gene (RIG-I)-like helicases (RLHs) can recognize viral RNA in the cytosol PMID: 18262306 The recognition of viral RNAs by these helicases induces production of type I IFNs and an associated antiviral response.

Go back
689.0, 1277.0
21.0, 21.0

p61

p61

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e113

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c164 : 1

m115*0.1

nodelay

--

true

0

false

PMID: 18262306 The recognition of viral RNAs by these helicases induces production of type I IFNs and an associated antiviral response.

Go back
745.0, 1277.0
21.0, 21.0

p61

p62

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e112

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m114*0.1

nodelay

--

true

0

false

PMID: 18262306 The recognition of viral RNAs by these helicases induces production of type I IFNs and an associated antiviral response.

Go back
954.0, 1398.0
19.0, 19.0

p63

p63

cso30:i:ME_DNABinding

cso30:i:CC_Cytosol

--

MO000061425 e115

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c170 : 1

m36323*m117*0.1

nodelay

--

true

0

false

PMID: 18262306,17618271 Recently, a potential cytoplasmic DNA receptor named DAI (also known as DLM1 or ZBP1) was identified

Go back
1038.0, 502.0
19.0, 19.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e12

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19828*m12*0.1

nodelay

--

true

0

false

PMID: 18262306,11130078 TLR9 was first cloned and identified as a receptor for unmethylated CpG-DNA as well as for bacterial DNA in 2000

Go back
1050.0, 566.0
19.0, 19.0

p7

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000042012

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m22*m19828*0.1

nodelay

--

true

0

false

PMID: 18262306,11130078 TLR9 was first cloned and identified as a receptor for unmethylated CpG-DNA as well as for bacterial DNA in 2000 PMID: 18262306 TLR9 also recognizes bacterial and viral DNA

Go back
1046.0, 646.0
19.0, 19.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000042012

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m24*m19828*0.1

nodelay

--

true

0

false

PMID: 18262306,15630134 In addition to DNA, hemozoin (HZ) derived from the malaria parasite Plasmodium acts as a TLR9 ligand

Go back
756.0, 64.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 412.8255305823146

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
582.0, 1585.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
586.9514924975441, 586.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
502.0, 1458.0

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
736.0, 1541.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.9870028021417, 586.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
779.0, 1232.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
890.0, 1242.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
883.1836771395313, 586.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1441.0, 1314.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1261.0, 1496.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1033.9628001084425, 409.7705935588815

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1237.0, 1502.6953686665047

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
707.0, 1177.2313082121048

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
972.0, 1165.5591388499581

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
961.248584567596, 586.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1149.0, 1175.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1244.0, 1311.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1194.2494651199622, 1298.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
224.99652015265568, 1324.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
60.14577023677901, 1360.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
224.89115139065714, 1302.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
975.2179353172033, 418.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
476.0, 462.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.32365176905034, 456.9001457431169

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.0, 444.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
377.40437564964543, 448.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
370.0, 597.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.0, 606.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
695.9221668432239, 1019.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
617.9989923798688, 1111.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1298.0, 724.7260383378604

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1229.0, 520.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
837.0, 265.87768608679755

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1338.0, 717.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1458.5183473879074, 804.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1369.0, 831.5944732131918

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1434.9684350024884, 839.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1514.6069714518937, 847.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1514.782449717483, 868.8529642184483

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1443.0, 873.5073890561713

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1468.5212577361842, 875.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1466.0, 944.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1402.0, 1071.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
906.7339445046937, 98.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1480.0640869902634, 954.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1361.9741116400949, 1097.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1337.6990699817188, 1125.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1345.0, 1193.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1507.0, 1217.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1571.0, 1249.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1493.0, 1227.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1509.0, 1345.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1474.0, 1000.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1544.653391043431, 983.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
879.2882842111075, 262.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1461.2208294496277, 1004.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1539.9040962700087, 1049.235015042189

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1454.0, 1041.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1409.894996663182, 1048.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1343.0, 1061.5271856147344

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1092.9793442748553, 350.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
997.0, 376.003096422895

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.5484620587898, 273.6496642328813

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
251.0, 460.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
307.5876987549066, 452.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
962.0, 98.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.0561610125072, 501.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
365.0501711869566, 479.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
335.0, 452.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
268.65685424949237, 541.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.0, 1298.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
261.0, 645.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
272.0, 561.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
717.4950642846643, 1298.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
903.0, 1408.4697761756117

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.8223117743427, 1422.4864091719767

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.0, 321.85007049754176

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
906.5047326640744, 1417.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
967.5320612097545, 322.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1000.0, 512.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
815.0, 81.74517529289281

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1065.0, 512.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
995.1972896011401, 520.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1077.0, 576.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.0, 520.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
979.9069755530128, 582.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1072.9975922650972, 652.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
996.0, 520.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
937.0, 656.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
982.0, 586.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.5842074051469, 716.544030462707

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
841.0, 74.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
911.0, 704.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
903.0, 711.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
984.9987028429207, 763.2929730966948

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.7927985842801, 766.0437687993774

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
755.3645916461811, 512.9347414829733

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
677.839493298193, 498.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
670.0, 520.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
611.9433355111145, 573.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
525.0, 588.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 591.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
56.0, 221.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
651.0961421925876, 646.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
562.0, 671.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.0, 696.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
583.7492919018569, 722.2950039375453

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
494.0, 712.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.4, 719.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
396.6136689420844, 771.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
388.5777087639997, 750.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
293.0, 804.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
285.0, 814.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
71.68995493908695, 218.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.0, 1029.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.9402850002907, 770.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
636.0126284062368, 824.8500704975418

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.9178268547516, 817.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
271.0, 872.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 882.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
347.0, 1020.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.1117964514128, 777.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
519.0, 844.0

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
506.0, 904.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
65.0, 264.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
576.0, 914.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
518.0, 980.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
501.0, 990.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
349.41688052563325, 1113.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
315.2397421507617, 1146.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.2414011824242, 1109.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
324.5876987549066, 1178.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
402.0, 1119.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
389.14618187819093, 1202.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
499.4743082804015, 1114.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
686.0, 64.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.84630528093555, 1197.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
410.0, 1119.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
465.0, 1186.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
517.0, 1114.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
526.2094390007583, 1198.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
892.0, 720.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.0, 791.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.1554175279994, 736.5777087639997

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.0745671513299, 744.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
621.9758970724826, 1011.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.0, 80.96659447277054

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
653.0, 724.1216320626955

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.0, 1210.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
331.9943100988534, 1260.301672079202

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
530.3460102252582, 1210.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
402.2414011824242, 1300.4003101204428

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
599.2738595105969, 1210.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
540.9294846883888, 1311.9977796279165

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
223.93997474141574, 1147.2925868729938

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
81.0, 1132.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
235.46406024173103, 1300.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.0, 74.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
69.99707975898284, 1408.2161372907833

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
263.57371822472527, 1310.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
62.0, 1488.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
436.0, 318.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
675.0, 377.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
682.7602596548804, 376.9438029964055

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
631.0, 256.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
719.3072455287698, 272.98607925919396

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
707.0, 267.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
580.0, 1420.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back