PMID: 18325755,17324405 Interestingly, TLR4 could also be activated by endogenous ligands produced during stress or cell damage, including heat-shock protein 60, ED-A domain of fibronectin, and hyaluronan

PMID: 18325755,14673019,12925853 There is now evidence that TIR8, an orphan member of the IL-1R family (also known as single immunoglobulin IL-1R-related molecule, SIGIRR) inhibits signalling from the IL-1R/TLR complexes, possibly by trapping IRAK-1 and TRAF-6

PMID: 18325755,14673019,12925853 There is now evidence that TIR8, an orphan member of the IL-1R family (also known as single immunoglobulin IL-1R-related molecule, SIGIRR) inhibits signalling from the IL-1R/TLR complexes, possibly by trapping IRAK-1 and TRAF-6

PMID: 18325755,12925853,14715412 Tir8 gene transfer experiments have revealed that it reduces NF-¦ÊB activation by the IL-1R complex ,as well as by members of the TLR family such as TLR4

PMID: 18325755,12925853,14715412 Tir8 gene transfer experiments have revealed that it reduces NF-¦ÊB activation by the IL-1R complex ,as well as by members of the TLR family such as TLR4

PMID: 18325755,12925853,14715412 Tir8 gene transfer experiments have revealed that it reduces NF-¦ÊB activation by the IL-1R complex ,as well as by members of the TLR family such as TLR4

PMID; 18325755,15542429 Transfer of activated ras oncogene into a cervical carcinoma line (HeLa) induces IL-8/CXCL8 production that is sufficient to promote angiogenesis and tumor progression

PMID; 18325755,15542429 Transfer of activated ras oncogene into a cervical carcinoma line (HeLa) induces IL-8/CXCL8 production that is sufficient to promote angiogenesis and tumor progression

PMID: 18325755,16801397 Braf, frequently activated in malignant melanoma, induces cytokine production that contributes to pro-tumor milieu

PMID: 18325755 TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGF¦Â, VEGF, chemokines, and cytokines

PMID: 18325755 TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGF¦Â, VEGF, chemokines, and cytokines

PMID: 18325755,17324405 Interestingly, TLR4 could also be activated by endogenous ligands produced during stress or cell damage, including heat-shock protein 60, ED-A domain of fibronectin, and hyaluronan

PMID: 18325755 TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGF¦Â, VEGF, chemokines, and cytokines

PMID: 18325755 TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGF¦Â, VEGF, chemokines, and cytokines

PMID: 18325755 TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGF¦Â, VEGF, chemokines, and cytokines

PMID: 18325755 TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGF¦Â, VEGF, chemokines, and cytokines PMID: 18325755 TAM produce several matrix metalloproteases (e.g. MMP2, MMP9) and activators of MMPs, such as chemokines.

PMID: 18325755 TAM produce several matrix metalloproteases (e.g. MMP2, MMP9) and activators of MMPs, such as chemokines.

PMID: 18325755 TAM produce several matrix metalloproteases (e.g. MMP2, MMP9) and activators of MMPs, such as chemokines.

PMID: 18325755,7547226 TAM also produce factors, such as TGF¦Â, PDGF, IL-6, urokinase plasminogen activator, and tissue-type plasminogen activator (t-PA) that may cause matrix degradation

PMID: 18325755,7547226 TAM also produce factors, such as TGF¦Â, PDGF, IL-6, urokinase plasminogen activator, and tissue-type plasminogen activator (t-PA) that may cause matrix degradation

PMID: 18325755,7547226 TAM also produce factors, such as TGF¦Â, PDGF, IL-6, urokinase plasminogen activator, and tissue-type plasminogen activator (t-PA) that may cause matrix degradation

PMID: 18325755,7547226 TAM also produce factors, such as TGF¦Â, PDGF, IL-6, urokinase plasminogen activator, and tissue-type plasminogen activator (t-PA) that may cause matrix degradation

PMID: 18325755,17324405 Interestingly, TLR4 could also be activated by endogenous ligands produced during stress or cell damage, including heat-shock protein 60, ED-A domain of fibronectin, and hyaluronan

PMID: 18325755 Chemokines have been shown to induce gene expression of various MMPs and, in particular, MMP-9 production, along with the uPA receptor

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PMID: 18325755,9192897 In normal macrophages CCL18 is inducible by Th2 cytokines: IL-4, IL-13, and IL-10 and recruit naive T cells by interacting with an unidentified receptor

PMID: 18325755,9192897 In normal macrophages CCL18 is inducible by Th2 cytokines: IL-4, IL-13, and IL-10 and recruit naive T cells by interacting with an unidentified receptor

PMID: 18325755,9192897 In normal macrophages CCL18 is inducible by Th2 cytokines: IL-4, IL-13, and IL-10 and recruit naive T cells by interacting with an unidentified receptor

PMID: 18325755,12401408,15229479 Two other chemokines, CCL17 and CCL22, are abundantly expressed by TAM

PMID: 18325755,12401408,15229479 Two other chemokines, CCL17 and CCL22, are abundantly expressed by TAM

PMID: 18325755,9419219 These chemokines interact with the CCR4 receptor, expressed mostly by Th2 cells and by Treg

PMID: 18325755,9419219 These chemokines interact with the CCR4 receptor, expressed mostly by Th2 cells and by Treg

PMID: 18325755,10702399 In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.

PMID: 18325755,12001991 Constitutive NF-¦ÊB activation, often observed in cancer cells, may be promoted by either microenvironmental signals, including cytokines, hypoxia, and reactive oxygen intermediates (ROI), or by genetic alterations

PMID: 18325755,10702399 In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.

PMID: 18325755,10702399 In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.