1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18585455.csml convertedTime:2009.07.01.11:20

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title NOD-like receptors (NLRs): bona fide intracellular microbial sensors.
Authors Shaw MH, Reimer T, Kim YG, Nunez G.
Affiliation Department of Pathology and Comprehensive Cancer Center, University of MichiganMedical School, Ann Arbor, MI 48109, USA.
Abstract The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR)(nucleotide-binding domain leucine-rich repeat containing) family of proteinshas been demonstrated to function as regulators of innate immune responseagainst microbial pathogens. Stimulation of NOD1 and NOD2, two prototypic NLRs,results in the activation of MAPK and NF-kappaB. On the other hand, a differentset of NLRs induces caspase-1 activation through the assembly of aninflammasome. This review discusses recent findings regarding the signalingpathways utilized by NLR proteins in the control of caspase-1 and NF-kappaBactivation, as well as the nonredundant role of NLRs in pathogen clearance. Thereview also covers advances regarding the cellular localization of theseproteins and the implications this may have on pathogen sensing and signaltransduction.
PMID 18585455
Model Abstract

Entity

MO000000011:ERK MO000000022:p38 MO000000023:JNK MO000000058:NF-kappaB MO000000209:TRAF2 MO000000210:IKK-alpha:IKK-beta:Nemo MO000000212:TRAF6 MO000016574:TAK1 MO000016591:A20 MO000016597:IL-1beta MO000016828:Caspase-1 MO000016965:TRAF5 MO000017949:RIP2 MO000019449:proIL-1beta MO000020434:Nod1 MO000020461:Nod2 MO000042032:PGN MO000044196:CARD9 e1: e11:Nod1{oligo}:PGN e12:Nod2{oligo}:PGN e13:Nod1{oligo}:PGN:RIP2 e14:Nod2{oligo}:PGN:RIP2 e15:Nod1{oligo}:PGN:RIP2{ub} e16:Nod2{oligo}:PGN:RIP2{ub} e17:Nod1{oligo}:PGN:RIP2{ub}:TAK1 e18:Nod2{oligo}:PGN:RIP2{ub}:TAK1 e2: e29:Nod1{oligo}:PGN:RIP2{ub}:TAK1:IKK e3: e30:Nod2{oligo}:PGN:RIP2{ub}:TAK1:IKK e31:Nod1{oligo}:PGN:RIP2{ub}:TAK1:IKK{active} e32:Nod2{oligo}:PGN:RIP2{ub}:TAK1:IKK{active} e33:p38{active} e34:JNK{active} e35:Nod2:CARD9 e36:L.momocytogenes e37:NF-kappaB{active} e38:ERK{active} e39:p38{p} e4: e40:TLR e41:Caspase-1{active} e42:NLRC4 e43:NLRP3 e5:Nod1:PGN e6:Nod2:PGN e7:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p4 p5 p6 p7 p8 p9
Model Detail
726.0, 1170.0
28.5, 28.5

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p23

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
370.0, 1314.0
20.0, 20.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p25 p27

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
650.0, 1282.0
20.0, 20.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p24

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
530.0, 1022.0
20.0, 20.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p20 p28

true true true true

csml-variable:Double

m53

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
278.0, 694.0
20.0, 20.0

TRAF2

--

MO000000209

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m180

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000209

--

Go back
554.0, 906.0
36.0, 36.0

IKK-alpha:IKK-beta:Nemo

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p13

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
622.0, 706.0
20.0, 20.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
458.0, 830.0
28.0, 28.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p11

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
542.0, 766.0
20.0, 20.0

A20

--

MO000016591

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p26

true true true true

csml-variable:Double

m1585

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
818.0, 590.0
27.0, 27.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
825.0, 485.0
22.0, 22.0

Caspase-1

--

MO000016828

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31 p32 p33 p34

true true true true

csml-variable:Double

m1765

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
526.0, 694.0
20.0, 20.0

TRAF5

--

MO000016965

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m1874

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016965

--

Go back
543.0, 623.0
18.0, 18.0

RIP2

--

MO000017949

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6

true true true true

csml-variable:Double

m2684

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017949

--

Go back
902.0, 782.0
20.0, 20.0

proIL-1beta

--

MO000019449

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

p30

true true true true

csml-variable:Double

m4012

10

false

infinite

0

unit false false false
InterProIPR003297
TRANSPATHMO000019449

--

Go back
453.0, 353.0
22.0, 22.0

Nod1

--

MO000020434

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m4923

10

false

infinite

0

unit false false false
InterProIPR007091
TRANSPATHMO000020434

--

Go back
713.0, 313.0
22.0, 22.0

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p18

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
638.0, 126.0
20.0, 20.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
699.0, 411.0
18.0, 18.0

CARD9

--

MO000044196

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p27

true true true true

csml-variable:Double

m21914

10

false

infinite

0

unit false false false
InterProIPR001315
TRANSPATHMO000044196

--

Go back
122.960025072722, 176.002208503098
985.6929518736332, 1431.2261661205155

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
404.0, 550.0
24.662983425414364, 27.403314917127076

Nod1{oligo}:PGN

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p5

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
608.0, 542.0
24.662983425414364, 27.403314917127076

Nod2{oligo}:PGN

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p6

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
378.5, 613.0
26.885850614791707, 37.51514039273262

Nod1{oligo}:PGN:RIP2

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5 p17

p7 p8

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
734.5, 613.0
26.885850614791707, 37.51514039273262

Nod2{oligo}:PGN:RIP2

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6 p26

p9

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
382.5, 757.0
26.885850614791707, 37.51514039273262

Nod1{oligo}:PGN:RIP2{ub}

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7 p8

p10 p17

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
734.5, 769.0
26.885850614791707, 37.51514039273262

Nod2{oligo}:PGN:RIP2{ub}

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p11 p26

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
385.0, 905.0
22.764705882352946, 37.94117647058824

Nod1{oligo}:PGN:RIP2{ub}:TAK1

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p12

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
705.0, 865.0
22.764705882352946, 37.94117647058824

Nod2{oligo}:PGN:RIP2{ub}:TAK1

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p13

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
122.960025072722, 176.002208503098
985.6929518736332, 1431.2261661205155

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
417.0, 1013.0
22.764705882352946, 37.94117647058824

Nod1{oligo}:PGN:RIP2{ub}:TAK1:IKK

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p14

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
142.67388411019456, 195.71606754057055
946.2652337986876, 1391.7984480455705

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
645.0, 985.0
22.764705882352946, 37.94117647058824

Nod2{oligo}:PGN:RIP2{ub}:TAK1:IKK

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p15

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
285.0, 1145.0
22.764705882352946, 37.94117647058824

Nod1{oligo}:PGN:RIP2{ub}:TAK1:IKK{active}

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p16 p19 p21 p22

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
909.0, 985.0
22.764705882352946, 37.94117647058824

Nod2{oligo}:PGN:RIP2{ub}:TAK1:IKK{active}

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p20 p23 p24 p25

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
491.0, 1331.0
25.0, 25.0

p38{active}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16 p25

--

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
586.0, 1314.0
20.0, 20.0

JNK{active}

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21 p24

--

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
901.5, 312.0
20.21729711714714, 24.755874020996497

Nod2:CARD9

--

e35

cso30:c:Complex

cso30:i:CC_Cell

--

p18

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
787.5, 126.0
24.548759704601398, 35.92501420185572

L.momocytogenes

--

e36

cso30:c:Cell

cso30:i:CC_Cell

--

--

p18

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
553.0, 1081.0
22.0, 22.0

NF-kappaB{active}

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19 p20 p28

p29

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
834.0, 1246.0
28.5, 28.5

ERK{active}

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22 p23

--

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
553.0, 1436.0
29.634146341463406, 23.707317073170728

p38{p}

--

e39

cso30:c:Protein

cso30:i:CC_Cell

--

p27

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
179.14452332951913, 230.21532085614774
873.3239553600388, 1322.7999414144163

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1058.5, 909.0
19.95527296645472, 38.623108967331724

TLR

--

e40

cso30:c:Complex

cso30:i:CC_Cell

--

--

p28

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
941.0, 541.0
22.0, 22.0

Caspase-1{active}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31 p32 p33 p34

p30

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
347.5, 406.0
16.679412356610992, 27.047695713423224

NLRC4

--

e42

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p33

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
957.0, 383.5
22.88, 17.16000000000001

NLRP3

--

e43

cso30:c:Protein

cso30:i:CC_Cell

--

--

p34

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
520.0, 411.0
23.171270718232037, 25.745856353591158

Nod1:PGN

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p3 p31

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
632.0, 371.0
23.171270718232037, 25.745856353591158

Nod2:PGN

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p4 p32

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
129.23255860729137, 196.64453580866305
965.1321237375424, 1367.5672897240463

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
521.0, 313.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042032 MO000020434

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155701*m4923*0.1

nodelay

--

true

0

false

PMID: 18585455,12796777,12791997 NOD1 activity is triggered by g-Dglutamyl- meso-diaminopimelic acid (meso-DAP) 1), which is unique to PGN structures from all Gram-negative bacteria and certain Gram-positive bacteria, including the genus Listeria and Bacillus

Go back
385.0, 833.0
21.0, 21.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000016574

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m15*m1573*0.1

nodelay

--

true

0

false

PMID: 18585455 K63-linked regulatory ubiquitination of RICK leads to the recruitment of TAK1. PMID: 18585455,18079694,18342009 Similar to TLR signaling, recent studies have demonstrated that K63-linked regulatory ubiquitination of RICK is essential for the recruitment of TAK1

Go back
597.0, 809.0
21.0, 21.0

p10

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000016574

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m16*m1573*0.1

nodelay

--

true

0

false

PMID: 18585455 K63-linked regulatory ubiquitination of RICK leads to the recruitment of TAK1. PMID: 18585455,18079694,18342009 Similar to TLR signaling, recent studies have demonstrated that K63-linked regulatory ubiquitination of RICK is essential for the recruitment of TAK1

Go back
465.0, 949.0
21.0, 21.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cell

--

e17 MO000000210

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m17*m181*0.1

nodelay

--

true

0

false

PMID: 18585455 The activation and recruitment of TAK1 complex to RICK further recruits the IKK complex

Go back
641.0, 937.0
21.0, 21.0

p12

p13

cso30:i:ME_Binding

cso30:i:CC_Cell

--

e18 MO000000210

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m18*m181*0.1

nodelay

--

true

0

false

PMID: 18585455 The activation and recruitment of TAK1 complex to RICK further recruits the IKK complex

Go back
358.0, 1086.0
19.0, 19.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1

Go back
758.0, 994.0
19.0, 19.0

p14

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e30

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1

Go back
434.0, 1230.0
19.0, 19.0

p14

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e31 MO000000022

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c47 : 1
stoichiometry:c55 : 1

m31*m33*0.1

nodelay

--

true

0

false

PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1 PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs

Go back
458.0, 778.0
19.0, 19.0

p17

p17

cso30:i:ME_Deubiquitination

cso30:i:CC_Cell

--

e15 MO000016591

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m15*m1585*0.1

nodelay

--

true

0

false

PMID: 18585455,18079694,18342009 As in the case of TLRs, this modification can be removed by the deubiquitinating enzyme A20, thus dampening NOD1/NOD2-induced NF-kB activation

Go back
789.0, 313.0
21.0, 21.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cell

--

MO000020461 MO000044196 e36

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c51 : 1
stoichiometry:c50 : 1

m4947*m21914*m36*0.1

nodelay

--

true

0

false

PMID: 18585455 Recently it was demonstrated that ectopically expressed CARD9, an essential protein in antifungal responses and TLR signaling, interacts with NOD2 after challenge with L. monocytogenes.

Go back
317.0, 1257.0
21.0, 21.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e31 MO000000058

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m31*m53*0.1

nodelay

--

true

0

false

PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs

Go back
637.0, 313.0
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042032 MO000020461

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m155701*m4947*0.1

nodelay

--

true

0

false

PMID: 18585455,12527755,12514169 In contrast, NOD2 is activated by muramyl dipeptide (MDP), a peptidogylcan motif present in all Gram-positive and Gram-negative bacteria

Go back
801.0, 1073.0
21.0, 21.0

p19

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e32 MO000000058

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c46 : 1

m32*m53*0.1

nodelay

--

true

0

false

PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs

Go back
514.0, 1218.0
19.0, 19.0

p14

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e31 MO000000023

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m31*m34*0.1

nodelay

--

true

0

false

PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1 PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs

Go back
658.0, 1218.0
19.0, 19.0

p14

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e31 MO000000011

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m31*m38*0.1

nodelay

--

true

0

false

PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1 PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs

Go back
834.0, 1094.0
19.0, 19.0

p14

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e32 MO000000011

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m32*m38*0.1

nodelay

--

true

0

false

PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1 PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs

Go back
594.0, 1162.0
19.0, 19.0

p14

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e32 MO000000023

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m32*m34*0.1

nodelay

--

true

0

false

PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1 PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs

Go back
522.0, 1158.0
19.0, 19.0

p14

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e32 MO000000022

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m32*m33*0.1

nodelay

--

true

0

false

PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1 PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs

Go back
814.0, 714.0
19.0, 19.0

p17

p26

cso30:i:ME_Deubiquitination

cso30:i:CC_Cell

--

e16 MO000016591

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c74 : 1

m16*m1585*0.1

nodelay

--

true

0

false

PMID: 18585455,18079694,18342009 As in the case of TLRs, this modification can be removed by the deubiquitinating enzyme A20, thus dampening NOD1/NOD2-induced NF-kB activation

Go back
426.0, 1426.0
19.0, 19.0

p27

p27

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell

--

MO000000022 MO000044196

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c78 : 1
stoichiometry:c77 : 1

m33*m21914*0.1

nodelay

--

true

0

false

PMID: 18585455,17187069 Furthermore, CARD9-deficient macrophages exhibited impaired phosphorylation of p38 after MDP stimulation, suggesting that CARD9 is another essential intermediate in the NOD2-signaling cascade that acts downstream of TAK1

Go back
914.0, 1174.0
19.0, 19.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

MO000000058 e40

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c80 : 1

m53*m43*0.1

nodelay

--

true

0

false

PMID: 18585455,17433728 TLR-mediated NF-kB is required for the production of pro-IL-1b while the cleavage of pro-IL-1b into its biologically active form is dependent on NLR-mediated caspase-1 activation

Go back
837.0, 845.0
21.0, 21.0

p29

p29

cso30:i:ME_UnknownProduction

cso30:i:CC_Cell

--

e37

MO000019449

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 18585455,17433728 TLR-mediated NF-kB is required for the production of pro-IL-1b while the cleavage of pro-IL-1b into its biologically active form is dependent on NLR-mediated caspase-1 activation

Go back
523.0, 555.0
17.0, 17.0

p3

p3

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e5

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 18585455 Upon ligand recognition, NOD1 and NOD2 undergo conformational changes and selfoligomerization.

Go back
900.0, 632.0
23.0, 23.0

p30

p30

cso30:i:ME_Cleavage

cso30:i:CC_Cell

--

MO000019449 e41

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c89 : 1
stoichiometry:c85 : 1

m4012*m44*0.1

nodelay

--

true

0

false

PMID: 18585455,17433728 TLR-mediated NF-kB is required for the production of pro-IL-1b while the cleavage of pro-IL-1b into its biologically active form is dependent on NLR-mediated caspase-1 activation

Go back
762.0, 394.0
19.0, 19.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

MO000016828 e5

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c86 : 1
stoichiometry:c88 : 1

m1765*m5*0.1

nodelay

--

true

0

false

PMID: 18585455,17433728 TLR-mediated NF-kB is required for the production of pro-IL-1b while the cleavage of pro-IL-1b into its biologically active form is dependent on NLR-mediated caspase-1 activation

Go back
862.0, 370.0
19.0, 19.0

p31

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

MO000016828 e6

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c99 : 1
stoichiometry:c92 : 1

m1765*m6*0.1

nodelay

--

true

0

false

PMID: 18585455,17433728 TLR-mediated NF-kB is required for the production of pro-IL-1b while the cleavage of pro-IL-1b into its biologically active form is dependent on NLR-mediated caspase-1 activation

Go back
465.0, 449.0
21.0, 21.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e42 MO000016828

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m45*m1765*0.1

nodelay

--

true

0

false

PMID: 18585455 NLRC4 has been demonstrated to mediate caspase-1 activation, independent of TLR5, following cytosolic delivery of flagellin. PMID: 18585455 Various intracellular bacteria have the ability to activate caspase-1 in a NLRC4-dependent manner

Go back
925.0, 441.0
21.0, 21.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e43 MO000016828

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m46*m1765*0.1

nodelay

--

true

0

false

PMID: 18585455 NLRP3 mediates activation of caspase-1 in response to a variety of structurally unrelated stimuli, not limiting to those of bacterial origin.

Go back
639.0, 455.0
17.0, 17.0

p3

p4

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e6

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 18585455 Upon ligand recognition, NOD1 and NOD2 undergo conformational changes and selfoligomerization.

Go back
473.0, 621.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017949 e11

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m2684*m11*0.1

nodelay

--

true

0

false

PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs

Go back
609.0, 621.0
21.0, 21.0

p5

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017949 e12

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c16 : 1
stoichiometry:c15 : 1

m2684*m12*0.1

nodelay

--

true

0

false

PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs

Go back
381.0, 689.0
21.0, 21.0

p7

p7

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e13 MO000000209

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m13*m180*0.1

nodelay

--

true

0

false

PMID: 18585455 Although, both NOD1 and NOD2 induce similar K63-linked ubiquitination of RICK for NF-kB activation, Nod2-signaling appears to preferentially utilize the E3 ligase TRAF6, whereas TRAF2 and TRAF5 were shown to be important for NOD1-mediated signaling.

Go back
441.0, 693.0
21.0, 21.0

p7

p8

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e13 MO000016965

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m13*m1874*0.1

nodelay

--

true

0

false

PMID: 18585455 Although, both NOD1 and NOD2 induce similar K63-linked ubiquitination of RICK for NF-kB activation, Nod2-signaling appears to preferentially utilize the E3 ligase TRAF6, whereas TRAF2 and TRAF5 were shown to be important for NOD1-mediated signaling.

Go back
737.0, 701.0
21.0, 21.0

p7

p9

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e14 MO000000212

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m14*m183*0.1

nodelay

--

true

0

false

PMID: 18585455 Although, both NOD1 and NOD2 induce similar K63-linked ubiquitination of RICK for NF-kB activation, Nod2-signaling appears to preferentially utilize the E3 ligase TRAF6, whereas TRAF2 and TRAF5 were shown to be important for NOD1-mediated signaling.

Go back
543.1996019394326, 146.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
626.3986127739231, 472.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
502.0, 632.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.0, 577.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
413.0, 632.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.0, 632.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.0, 632.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.0, 569.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 651.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.0, 700.3850952278855

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
393.0, 710.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
475.0, 335.04960455011377

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
405.0, 648.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
470.0, 704.0

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
413.91152490811936, 714.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.0, 651.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
642.0, 712.3365439158895

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
748.0, 722.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
396.0, 795.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
414.0, 844.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
396.0, 854.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
625.795129565557, 791.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
532.0, 334.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
486.0, 823.4185980428581

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.0, 826.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.0, 929.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
493.50862842717004, 931.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.40250689707057, 970.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
667.6568542494924, 895.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
590.0, 929.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
653.0, 958.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
382.51724137931035, 1044.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.8255999415424, 1105.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
648.0, 146.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
668.0, 1004.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
777.0, 1004.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
308.0, 1170.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
828.4088289110299, 1012.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
550.0, 1034.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
409.0, 778.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
582.9949925666011, 1084.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
388.0, 1255.3881871059364

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
735.0, 324.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
717.0, 339.8056398354918

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
666.0, 324.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
810.0, 324.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
800.0, 162.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
302.0, 1183.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
343.3440644051947, 1042.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
338.0, 1104.7952332202017

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
449.0, 1249.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
308.0, 1167.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
540.23995138211, 1235.4033959488552

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.0, 1237.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
308.0, 1166.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
645.43180206412, 334.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.8228104326101, 1192.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.0, 1230.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
856.8406661402685, 1019.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
755.0, 1116.889298509159

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.0, 1113.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.0673973236475, 1010.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
611.375218976989, 1188.2531301420402

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
597.4204706649821, 1181.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
548.3727058262007, 1009.0

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
390.0, 1182.740029624963

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
532.0, 437.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
507.2819195991781, 1177.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.90697358120497, 777.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
404.5096194278744, 658.189059150646

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
761.0, 737.1778465754876

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
766.1214751973158, 654.145770236779

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
562.0, 727.49689686312

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
385.0, 1334.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
445.0, 1437.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
441.06950124744816, 429.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
550.0, 1036.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
437.0, 564.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
582.7543656297053, 1096.9671842010462

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
933.9264244561156, 945.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
575.0, 870.1168563450082

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
858.0, 807.6568542494924

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.0, 663.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
852.1813408844941, 614.5253855251153

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
543.0, 405.65532445383565

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
782.5631664759627, 419.5709597253864

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
781.0, 411.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.1898088913156, 563.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
645.0, 397.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
839.0, 396.63583982428025

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
876.0, 389.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
364.0, 423.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
493.96006469687126, 461.7983545713676

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.0, 462.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
945.7186711919194, 401.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
847.0, 460.19668336411144

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.0, 462.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
655.0, 380.15456051789454

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back