_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e4
_enti_e2
_enti_e3
_enti_e55
_enti_e53
_enti_e59
_enti_e54
_enti_e56
_enti_e51
_enti_e52
_enti_e50
_enti_e61
_enti_e57
_enti_e58
_enti_e62
_enti_e60
g2_fact_g2
g1_fact_g14
g2_fact_g12
g2_fact_g13
g1_fact_g1
p1_propro_p1
PMID: 7542643, 1698311
CD14 has been assigned a functional role, serving as a receptor for LPS in association with LBP in which heparinized human blood cultured for 16 h with LPS resulted in TNF-alpha production,
whose synthesis and release could be nearly eliminated by pre-treatment with a CD14 blocking mAb
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 7542643, 1698311
CD14 has been assigned a functional role, serving as a receptor for LPS in association with LBP in which heparinized human blood cultured for 16 h with LPS resulted in TNF-alpha production,
whose synthesis and release could be nearly eliminated by pre-treatment with a CD14 blocking mAb.
Binding of erythrocyte- LPS complexes to macrophages could be inhibited by preincubation of macrophages with
anti-CD14 blocking mAb.
c4 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c12 cso30:c:InputInhibitor connector
c61 cso30:c:OutputProcess connector
c62 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 7542643, 1698311
CD14 has been assigned a functional role, serving as a receptor for LPS in association with LBP in which heparinized human blood cultured for 16 h with LPS resulted in TNF-alpha production,
whose synthesis and release could be nearly eliminated by pre-treatment with a CD14 blocking mAb
c8 cso30:c:InputAssociation connector
c7 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 7542643, 1376258
CD14 plays an important role in macrophage production of IL-1 in response to LPS.
The LPS-induced synthesis of these cytokines could be blocked with the anti-CD14 mAb MEM-18.
c15 cso30:c:InputAssociation connector
c14 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 7542643, 1376258
CD14 plays an important role in macrophage production of IL-1 in response to LPS.
The LPS-induced synthesis of these cytokines could be blocked with the anti-CD14 mAb MEM-18.
c16 cso30:c:InputAssociation connector
c18 cso30:c:InputInhibitor connector
c19 cso30:c:InputAssociation connector
c17 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 7542643, 7681082
A recent report described the importance of CD14 in LPS recognition by human monocytes and alveolar macrophages, leading to the
synthesis and release of TNF-alpha, IL-6, and IL-8.
The LPS-induced synthesis of these cytokines could be blocked with the anti-CD14 mAb MEM-18.
PMID: 7542643
Inhibition of LPS induced IL-6 and E-selectin expression by anti-CD14 mAb was maximal at low concentrations of LPS.
c21 cso30:c:InputAssociation connector
c13 cso30:c:InputInhibitor connector
c20 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 7542643, 7681082
A recent report described the importance of CD14 in LPS recognition by human monocytes and alveolar macrophages, leading to the
synthesis and release of TNF-alpha, IL-6, and IL-8.
The LPS-induced synthesis of these cytokines could be blocked with the anti-CD14 mAb MEM-18.
c29 cso30:c:InputAssociation connector
c26 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 7542643, 7681082
A recent report described the importance of CD14 in LPS recognition by human monocytes and alveolar macrophages, leading to the synthesis and release of TNF-alpha, IL-6, and IL-8. The LPS-induced synthesis of these cytokines could be blocked with the anti-CD14 mAb MEM-18.
c22 cso30:c:InputAssociation connector
c25 cso30:c:InputInhibitor connector
c24 cso30:c:InputAssociation connector
c23 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 7542643, 7681082
A recent report described the importance of CD14 in LPS recognition by human monocytes and alveolar macrophages, leading to the
synthesis and release of TNF-alpha, IL-6, and IL-8.
The LPS-induced synthesis of these cytokines could be blocked with the anti-CD14 mAb MEM-18.
c27 cso30:c:InputAssociation connector
c30 cso30:c:InputInhibitor connector
c31 cso30:c:InputAssociation connector
c28 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 7542643, 1708813
TNF-alpha, GM-CSF, G-CSF, and formyl peptide have been shown to induce a twofold increase in CD14 expression.
c32 cso30:c:InputProcess connector
c33 cso30:c:InputProcess connector
c34 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 7542643, 1708813
TNF-alpha, GM-CSF, G-CSF, and formyl peptide have been shown to induce a twofold increase in CD14 expression.
c36 cso30:c:InputAssociation connector
c35 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 7542643, 1708813
TNF-alpha, GM-CSF, G-CSF, and formyl peptide have been shown to induce a twofold increase in CD14 expression.
c37 cso30:c:InputProcess connector
c38 cso30:c:InputProcess connector
c39 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 7542643, 1708813
TNF-alpha, GM-CSF, G-CSF, and formyl peptide have been shown to induce a twofold increase in CD14 expression.
c41 cso30:c:InputAssociation connector
c40 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 7542643, 1708813
TNF-alpha, GM-CSF, G-CSF, and formyl peptide have been shown to induce a twofold increase in CD14 expression.
c42 cso30:c:InputProcess connector
c43 cso30:c:InputProcess connector
c44 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 7542643, 1708813
TNF-alpha, GM-CSF, G-CSF, and formyl peptide have been shown to induce a twofold increase in CD14 expression.
c46 cso30:c:InputAssociation connector
c45 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 7542643
LPS appears to upregulate CD 14 transcripts, followed by increased expression of CDI4 protein on the cell surface.
c48 cso30:c:InputAssociation connector
c47 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 7542643
LPS appears to upregulate CD 14 transcripts, followed by increased expression of CDI4 protein on the cell surface.
c50 cso30:c:InputAssociation connector
c51 cso30:c:InputAssociation connector
c49 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 7542643
recombinant sCD14 produced using a baculovirus expression system was shown to specifically bind LPS
c52 cso30:c:InputProcess connector
c53 cso30:c:InputProcess connector
c54 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 7542643
Inhibition of LPS induced IL-6 and E-selectin expression by anti-CD14 mAb was maximal at low concentrations of
LPS.
c56 cso30:c:InputAssociation connector
c92 cso30:c:InputInhibitor connector
c55 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 7542643
Inhibition of LPSinduced IL-6 and E-selectin expression by anti-CD14 mAb was maximal at low concentrations of
LPS.
c59 cso30:c:InputAssociation connector
c11 cso30:c:InputInhibitor connector
c58 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 7542643, 2402637
In rabbit peritoneal macrophages, addition of LBP enhanced TNF-alpha production when cells were stimulated with LPS. This
increase in TNF-alpha protein was accompanied by a concomitant increase in the rate and synthesis of TNF-alpha mRNA as visualized on Northern blots.
c63 cso30:c:InputAssociation connector
c6 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 7542643, 2402637
In rabbit peritoneal macrophages, addition of LBP enhanced TNF-alpha production when cells were stimulated with LPS. This
increase in TNF-alpha protein was accompanied by a concomitant increase in the rate and synthesis of TNF-alpha mRNA as visualized on Northern blots.
PMID: 7542643, 1698311
CD14 has been assigned a functional role, serving as a receptor for LPS in association with LBP in which heparinized human blood cultured for 16 h with LPS resulted in TNF-alpha production,
whose synthesis and release could be nearly eliminated by pre-treatment with a CD14 blocking mAb
c64 cso30:c:InputAssociation connector
c66 cso30:c:InputAssociation connector
c91 cso30:c:InputInhibitor connector
c65 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 7542643, 1607653
when LBP was added during LPS stimulation, macrophages responded with a more rapid induction of
TNF-alpha and IL-lbeta mRNA, higher steady state mRNA levels, and increased mRNA stability which was shown to correlate with increased TNF-alpha and
IL-lbeta protein.
c68 cso30:c:InputAssociation connector
c67 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 7542643, 1607653
when LBP was added during LPS stimulation, macrophages responded with a more rapid induction of
TNF-alpha and IL-lbeta mRNA, higher steady state mRNA levels, and increased mRNA stability which was shown to correlate with increased TNF-alpha and
IL-lbeta protein.
c69 cso30:c:InputAssociation connector
c71 cso30:c:InputAssociation connector
c70 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 7542643
All three members of the CD18 family (CDlla/CD18, CDllb/CD18, and CD 1Ic/CD 18) are capable of binding LPS.
c72 cso30:c:InputProcess connector
c73 cso30:c:InputProcess connector
c74 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 7542643
All three members of the CD18 family (CDlla/CD18, CDllb/CD18, and CD 1Ic/CD 18) are capable of binding LPS.
c75 cso30:c:InputProcess connector
c76 cso30:c:InputProcess connector
c77 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 7542643
All three members of the CD18 family (CDlla/CD18, CDllb/CD18, and CD 1Ic/CD 18) are capable of binding LPS.
c78 cso30:c:InputProcess connector
c79 cso30:c:InputProcess connector
c80 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 7542643, 1717586
LPS treatment has been shown to induce a rapid upregulation of CDllb/ CD 18 expression on human neutrophils, believed to be mediated by CD14, since anti-CD14 mAb specifically inhibited LPS-induced CDllb/CD18 expression (Lynn et al., 1991).
c83 cso30:c:InputAssociation connector
c90 cso30:c:InputInhibitor connector
c81 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 7542643, 1717586
LPS treatment has been shown to induce a rapid upregulation of CDllb/ CD 18 expression on human neutrophils, believed to be mediated by CD14, since anti-CD14 mAb specifically inhibited LPS-induced CDllb/CD18 expression (Lynn et al., 1991).
c84 cso30:c:InputAssociation connector
c89 cso30:c:InputInhibitor connector
c82 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 7542643, 2456339
one of the most well-characterized LPS receptors in addition to CD18 and CD14, is the 73 kDa (80 kDa) receptor.
PMID: 7542643
Two mAb were obtained from a series of clones, designated mAb 3D7 and mAb 5D3 were able to inhibit the interaction of LPS with the 73 kDa LPS receptor in a dose-dependent manner, reflecting specificity.
c85 cso30:c:InputProcess connector
c86 cso30:c:InputProcess connector
c88 cso30:c:InputInhibitor connector
c99 cso30:c:InputInhibitor connector
c87 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 7542643, 2002021
The p73 receptor has been demonstrated to bind soluble peptidoglycan on mouse B lymphocytes.
c93 cso30:c:InputProcess connector
c95 cso30:c:InputProcess connector
c94 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 7542643, 7690343
A 38 kDa cell surface protein displaying affinity for LPS was identified on mouse lymphocytes, macrophages, splenocytes, J774.1 cells and 70Z/3
cells using 125I-ASD-LPS.
c96 cso30:c:InputProcess connector
c97 cso30:c:InputProcess connector
c98 cso30:c:OutputProcess connector
p12_propro_p4
PMID: 7542643, 1708813
TNF-alpha, GM-CSF, G-CSF, and formyl peptide have been shown to induce a twofold increase in CD14 expression.
c10 cso30:c:InputAssociation connector
c9 cso30:c:OutputProcess connector
LPS_enti_e5
LPS
LBP_enti_e6
LBP
LPS:LBP_enti_e11
LPS:LBP
CD14_enti_e12
CD14
TNF-alpha_enti_e14
TNF-alpha
TNF-alpha_enti_e15
TNF-alpha
CD14 mAb_enti_e16
CD14 mAb
IL-1_enti_e17
IL-1
IL-1_enti_e18
IL-1
IL-6_enti_e19
IL-6
IL-6_enti_e20
IL-6
IL-8_enti_e21
IL-8
IL-8_enti_e22
IL-8
TNF-alpha_enti_e23
TNF-alpha
TNFR_enti_e24
TNFR
TNF-alpha:TNFR_enti_e25
TNF-alpha:TNFR
CD14_enti_e26
CD14
GM-CSF_enti_e27
GM-CSF
GM-CSFR_enti_e28
GM-CSFR
GM-CSF:GMCSFR_enti_e29
GM-CSF:GMCSFR
G-CSF_enti_e30
G-CSF
GCSFR_enti_e31
GCSFR
G-CSF:G-CSFR_enti_e32
G-CSF:G-CSFR
sCD14_enti_e34
sCD14
LPS:sCD14_enti_e35
LPS:sCD14
E-selectin_enti_e36
E-selectin
LPS:CD14_enti_e38
LPS:CD14
IL-1beta_enti_e13
IL-1beta
IL-1beta_enti_e39
IL-1beta
CD11a:CD18_enti_e40
CD11a:CD18
LPS:CD11a:CD18_enti_e41
LPS:CD11a:CD18
Cd11b:CD18_enti_e42
Cd11b:CD18
LPS:CD11b:CD18_enti_e43
LPS:CD11b:CD18
CD11c:CD18_enti_e44
CD11c:CD18
LPS:CD11c:CD18_enti_e45
LPS:CD11c:CD18
CD11b_enti_e46
CD11b
CD18_enti_e47
CD18
p73_enti_e48
p73
LPS:p73_enti_e49
LPS:p73
mAb3D7_enti_e63
mAb3D7
mAb5D3_enti_e64
mAb5D3
peptidoglycan:p73_enti_e65
peptidoglycan:p73
peptidoglycan_enti_e66
peptidoglycan
unknown recptor_enti_e67
unknown recptor
LPS:Unknown receptor_enti_e68
LPS:Unknown receptor
formyl peptide_enti_e33
formyl peptide