1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/7744810.csml convertedTime:2009.07.01.11:22

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Signals and receptors involved in recruitment of inflammatory cells.
Authors Ben-Baruch A, Michiel DF, Oppenheim JJ.
Affiliation Laboratory of Molecular Immunoregulation, NCI, National Institutes of Health,Frederick, Maryland 21702-1201, USA.
Abstract
PMID 7744810
Model Abstract

Entity

G010329:TNF-alpha G010342:GROA MO000000064:PLD MO000000104:PKC MO000000132:PLC MO000000133:PLCbeta MO000000193:RelA-p65 MO000000214:IL-1 MO000000289:TNF-alpha MO000000314:GPCR MO000000315:trimeric G-proteins((Galpha:GDP):Gbeta:Ggamma) MO000000331:PIP2 MO000011134:PLCbeta1 MO000016597:IL-1beta MO000016665:IFNgamma MO000017053:IL-4 MO000017264:IL-8 MO000017280:MCP-1 MO000018975:PLCbeta2 MO000019827:ENA-78 MO000019893:MCP-2 MO000019897:MCP-3 MO000022274:C5aR MO000033474:fMLP MO000033607:C5a MO000042409:LPS e1: e10: e11:Lectin e12:Endotoxin e13:Phorbol 12-myristate e14:13-acetate e15:Hepatitis B virus protein X e16:Dexamethasone e17:IL-1 e18:Interferon-beta e19:GRObeta e2: e20:GROgamma e21:ENA-78 e22:ENA-78 e23:IP-10 e24:MIP-1alpha e25:GMCSF e26:IL-8R e27:C5aR e28:fMLPR e29:GCSF e3: e30:IL-8RA e31:IL-8:IL-8RA e32:IL-8RB e33:IL-8:IL-8RB e34:Ligand e35:GPCR:Ligand e36:trimeric G-proteins{active} e37:G-protein alpha:GTP e38:G-protein beta:gamma e39:trimeric G-proteins{active}((Galpha:GTP):Gbeta:Ggamma) e4: e40:PLCbeta1{active} e41:PLCbeta2{active} e42:IP3 e43:DG e44:Calcium e45:PKC{active} e46:PLC{active} e47:PLD{active} e48:Phosphatidic acid e49:PAF e5:IL-8 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Bacteria e60: e61: e62: e63:LTB4 e64:C5a:C5aR e65:PLCbeta{active} e66:MAP Kinase e67:MAP Kinase{active} e68:Il-8 gene e69:NF-IL-6 e7: e70:Il-8 gene: RelaA:NF-IL-6 e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p7 p8 p9
Model Detail
616.0, 796.0
24.0, 24.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p11

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
455.0, 1059.0
26.0, 26.0

GROA

--

G010342

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p13 p16

--

true true true true

csml-variable:Double

m93320

10

false

infinite

0

unit false false false
TRANSFACG010342

--

Go back
527.0, 587.0
18.0, 18.0

PLD

--

MO000000064

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
TRANSPATHMO000000064

--

Go back
911.0, 431.0
25.0, 25.0

PKC

--

MO000000104

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
352.0, 528.0
16.0, 16.0

PLC

--

MO000000132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m119

10

false

infinite

0

unit false false false
TRANSPATHMO000000132

--

Go back
864.0, 220.0
23.0, 23.0

PLCbeta

--

MO000000133

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58

true true true true

csml-variable:Double

m120

10

false

infinite

0

unit false false false
TRANSPATHMO000000133

--

Go back
613.0, 1177.0
22.0, 22.0

RelA-p65

--

MO000000193

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m166

10

false

infinite

0

unit false false false
TRANSPATHMO000000193

--

Go back
104.0, 476.0
24.0, 24.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p16 p17 p18

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
107.0, 543.0
18.0, 18.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
320.0, 140.0
24.0, 24.0

GPCR

--

MO000000314

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m249

10

false

infinite

0

unit false false false
TRANSPATHMO000000314

--

Go back
418.0, 202.0
20.0, 20.0

trimeric G-proteins((Galpha:GDP):Gbeta:Ggamma)

--

MO000000315

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m250

10

false

infinite

0

unit false false false
TRANSPATHMO000000315

--

Go back
499.0, 403.0
18.5, 18.5

PIP2

--

MO000000331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p40

true true true true

csml-variable:Double

m290229

10

false

infinite

0

unit false false false
TRANSPATHMO000000331

--

Go back
779.0, 247.0
25.0, 25.0

PLCbeta1

--

MO000011134

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m1237

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000011134

--

Go back
1095.0, 943.0
26.0, 26.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
98.0, 1058.0
20.0, 20.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p23

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
98.0, 1134.0
19.0, 19.0

IL-4

--

MO000017053

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m1947

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000017053

--

Go back
85.0, 733.0
22.0, 22.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
1083.0, 259.0
18.0, 18.0

MCP-1

--

MO000017280

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m2133

10

false

infinite

0

unit false false false
InterProIPR008097
TRANSPATHMO000017280

--

Go back
639.0, 347.0
26.0, 26.0

PLCbeta2

--

MO000018975

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p41

true true true true

csml-variable:Double

m3586

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000018975

--

Go back
903.0, 1127.0
18.0, 18.0

ENA-78

--

MO000019827

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m4356

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000019827

--

Go back
1130.0, 306.0
20.0, 20.0

MCP-2

--

MO000019893

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m4422

10

false

infinite

0

unit false false false
InterProIPR000827
TRANSPATHMO000019893

--

Go back
1105.0, 529.0
22.0, 22.0

MCP-3

--

MO000019897

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m4426

10

false

infinite

0

unit false false false
InterProIPR000531
TRANSPATHMO000019897

--

Go back
1022.0, 158.0
20.0, 20.0

C5aR

--

MO000022274

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m6571

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000022274

--

Go back
102.0, 302.0
19.0, 19.0

fMLP

--

MO000033474

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48 p53

true true true true

csml-variable:Double

m138859

10

false

infinite

0

unit false false false
TRANSPATHMO000033474

--

Go back
1102.0, 470.0
19.0, 19.0

C5a

--

MO000033607

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49 p57

true true true true

csml-variable:Double

m12280

10

false

infinite

0

unit false false false
InterProIPR002890
TRANSPATHMO000033607

--

Go back
1097.0, 641.0
22.0, 22.0

LPS

--

MO000042409

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p24 p29 p30

true true true true

csml-variable:Double

m157177

10

false

infinite

0

unit false false false
TRANSPATHMO000042409

--

Go back
143.75, 119.99690800911759
928.2163568825613, 1347.7701501934785

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
168.02002945258928, 157.24552386202217
879.0148530088278, 1236.5267327700053

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
100.0, 935.0
15.043030869971934, 34.71468662301215

Lectin

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
101.0, 611.5
22.559999999999995, 16.92

Endotoxin

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1089.0, 733.0
37.468460891505465, 21.232127838519762

Phorbol 12-myristate

--

e13

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1095.0, 792.0
42.18671152228763, 23.905803195962992

13-acetate

--

e14

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1100.0, 868.5
24.24632722881867, 14.95190179110485

Hepatitis B virus protein X

--

e15

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
87.0, 380.0
42.18671152228764, 23.905803195963

Dexamethasone

--

e16

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
645.0, 780.0
45.77854671280277, 24.41522491349481

IL-1

--

e17

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p12

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
100.5, 999.0
15.972026564701148, 25.900583618434286

Interferon-beta

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
553.0, 1074.0
37.68166089965398, 20.096885813148788

GRObeta

--

e19

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p14 p17

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
143.75, 119.99690800911759
928.2163568825613, 1347.7701501934785

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
690.0, 1058.0
36.43598615916955, 19.432525951557093

GROgamma

--

e20

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p15 p18

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
762.0, 1114.0
36.07266435986159, 19.238754325259517

ENA-78

--

e21

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p20 p21

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1107.0, 1067.0
18.0, 18.0

ENA-78

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19

--

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000019827

--

Go back
495.0, 1117.0
42.30103806228374, 22.560553633217992

IP-10

--

e23

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p22

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
636.0, 1139.0
47.85467128027682, 25.522491349480973

MIP-1alpha

--

e24

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p23 p24

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1083.0, 580.5
25.477963372912054, 15.7114107466291

GMCSF

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p25 p26 p27

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
659.0, 859.0
50.24221453287197, 26.795847750865054

IL-8R

--

e26

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p25 p28 p29

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
693.0, 1006.0
53.35640138408304, 28.456747404844293

C5aR

--

e27

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p26

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
701.0, 812.0
45.674740484429066, 24.3598615916955

fMLPR

--

e28

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p27 p30

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1100.5, 1003.0
15.681626081706584, 25.429663916280944

GCSF

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p28

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
162.31432713765122, 138.5612351467689
891.0877026072588, 1310.6414959181773

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
166.5, 697.0
19.488576449912124, 29.982425307557126

IL-8RA

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
170.5, 761.0
19.506687130015347, 37.75487831615874

IL-8:IL-8RA

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
170.5, 813.0
19.488576449912124, 29.982425307557126

IL-8RB

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p32

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
170.5, 865.0
19.506687130015347, 37.75487831615874

IL-8:IL-8RB

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
314.0, 79.5
28.8347756087744, 17.781444958744217

Ligand

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
475.5, 135.0
17.88226266169699, 34.61083095812321

GPCR:Ligand

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
491.0, 271.0
18.0, 18.0

trimeric G-proteins{active}

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
TRANSPATHMO000000315

--

Go back
796.5, 295.0
15.689072247937208, 25.441738780438712

G-protein alpha:GTP

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
567.5, 309.0
24.700049991668052, 30.244959173471095

G-protein beta:gamma

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
679.0, 247.0
18.0, 18.0

trimeric G-proteins{active}((Galpha:GTP):Gbeta:Ggamma)

--

e39

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSPATHMO000000315

--

Go back
196.6583323423061, 171.04880763765843
822.3996921979497, 1245.6663509363973

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
851.0, 363.0
25.0, 25.0

PLCbeta1{active}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000011134

--

Go back
711.0, 395.0
25.0, 25.0

PLCbeta2{active}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000018975

--

Go back
491.0, 472.0
42.18671152228764, 23.90580319596299

IP3

--

e42

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
638.0, 490.0
36.080740117746, 20.445752733389398

DG

--

e43

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
356.5, 424.0
23.713317328061006, 24.115237960740004

Calcium

--

e44

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
747.0, 515.0
25.0, 25.0

PKC{active}

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
512.0, 624.0
16.0, 16.0

PLC{active}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44

--

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSPATHMO000000132

--

Go back
667.0, 611.0
18.0, 18.0

PLD{active}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000000064

--

Go back
774.0, 595.0
37.771236333052975, 21.403700588730022

Phosphatidic acid

--

e48

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1090.0, 351.0
11.455565949485504, 26.435921421889624

PAF

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p50

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
399.0, 877.0
41.418685121107266, 22.089965397923876

IL-8

--

e5

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
287.0, 700.7383728674235
634.04538587124, 575.0095026430054

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
355.4816245447521, 714.365262147732
370.7453466733136, 557.2987376745352

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
295.2650236519529, 708.413037687094
617.5153385673347, 559.6601730036642

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
296.4457413165176, 709.5937553516592
615.1539032382044, 557.2987376745352

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
287.0, 700.7383728674235
634.04538587124, 575.0095026430054

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
287.0, 700.7383728674235
634.04538587124, 575.0095026430054

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
296.4457413165176, 709.5937553516592
615.1539032382044, 557.2987376745352

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
749.8413245093591, 936.8819057803621
39.61167194427938, 35.85898723376874

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
645.9381700276667, 1102.1823788194192
54.87660027602453, 49.6777644604012

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
287.0, 700.7383728674235
634.04538587124, 575.0095026430054

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
93.5, 877.0
20.2787350880515, 29.676197689831465

Bacteria

--

e6

cso30:c:Cell

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
436.44092992202343, 956.2678444993396
20.07928573870983, 9.667804244564005

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
435.7704257351514, 927.4361644638443
68.72667915437876, 123.70802247788178

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
464.60210577064754, 1007.8966668884833
10.728066989951799, 10.728066989951808

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1097.5, 417.0
13.276514389213121, 21.529482793318575

LTB4

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p51

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1027.5, 219.0
17.141416356062265, 33.17693488270116

C5a:C5aR

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
916.0, 276.0
23.0, 23.0

PLCbeta{active}

--

e65

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
TRANSPATHMO000000133

--

Go back
858.0, 636.5
20.959999999999994, 15.72

MAP Kinase

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p60

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
898.0, 688.5
20.959999999999994, 15.72

MAP Kinase{active}

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

p60

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
406.0, 1165.5
60.0, 13.0

Il-8 gene

--

e68

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p47

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
465.76, 1207.82
21.279999999999994, 15.96

NF-IL-6

--

e69

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p47

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
168.0, 125.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
646.5, 1230.0
19.77573866764544, 27.594053954854097

Il-8 gene: RelaA:NF-IL-6

--

e70

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p47

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
158.0, 146.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
177.0, 172.0
878.0402226789811, 1263.9649135534519

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
374.0, 950.0
19.0, 19.0

p2

p1

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c22 : 1
stoichiometry:c3 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 7744810,7584498,3260265 Numerous exogenous agents and endogenous proinflammatory stimulants, such as endotoxin, lectins, hypoxia, viruses, bacteria, IL-1, and TNF-alpha, stimulate IL-8 production in a wide variety of cell types,by stabilization of IL-8 mRNA as well as by activation of IL-8 gene transcription PMID: 7744810 Glucocorticoids, such as dexamethasone, are potent immunomodulating anti-inflammatory agents that have a marked inhibitory effect on the gene transcription of several proinflammatory cytokines including IL-1, TNF-alpha, and IL-8.

Go back
633.0, 965.0
21.0, 21.0

p4

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e15 e16

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c28 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 7744810 Analysis of the IL-8 promoter showed that the sequences between positions -91 and -71 contain the NF-KappaB-binding site and the NF-IL-6 (or C/EBP) site and are sufficient for the induction of IL-8 gene transcription by LPS, IL-1, TNF-alpha, phorbol 12-myristate 13-acetate, or hepatitis B virus protein X. PMID: 7744810 Glucocorticoids, such as dexamethasone, are potent immunomodulating anti-inflammatory agents that have a marked inhibitory effect on the gene transcription of several proinflammatory cytokines including IL-1, TNF-alpha, and IL-8.

Go back
569.0, 737.0
21.0, 21.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 7744810 Glucocorticoids, such as dexamethasone, are potent immunomodulating anti-inflammatory agents that have a marked inhibitory effect on the gene transcription of several proinflammatory cytokines including IL-1, TNF-alpha, and IL-8.

Go back
629.0, 733.0
21.0, 21.0

p11

p12

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 7744810 Glucocorticoids, such as dexamethasone, are potent immunomodulating anti-inflammatory agents that have a marked inhibitory effect on the gene transcription of several proinflammatory cytokines including IL-1, TNF-alpha, and IL-8.

Go back
353.0, 1041.0
21.0, 21.0

p13

p13

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 7744810,2217207 IL-1 and TNF-alpha stimulate the expression of many of the alpha-chemokines including GROalpha, GRObeta (MIP-2alpha), and GROgamma (MIP-2 beta) in monocytes, fibroblasts, endothelial cells, and mammary epithelial cells through NF-KappaB sites in their promoters

Go back
565.0, 973.0
21.0, 21.0

p13

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 7744810,2217207 IL-1 and TNF-alpha stimulate the expression of many of the alpha-chemokines including GROalpha, GRObeta (MIP-2alpha), and GROgamma (MIP-2 beta) in monocytes, fibroblasts, endothelial cells, and mammary epithelial cells through NF-KappaB sites in their promoters

Go back
634.0, 994.0
19.0, 19.0

p13

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 7744810,2217207 IL-1 and TNF-alpha stimulate the expression of many of the alpha-chemokines including GROalpha, GRObeta (MIP-2alpha), and GROgamma (MIP-2 beta) in monocytes, fibroblasts, endothelial cells, and mammary epithelial cells through NF-KappaB sites in their promoters

Go back
433.0, 997.0
21.0, 21.0

p13

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m185*0.1

nodelay

--

true

0

false

PMID: 7744810,2217207 IL-1 and TNF-alpha stimulate the expression of many of the alpha-chemokines including GROalpha, GRObeta (MIP-2alpha), and GROgamma (MIP-2 beta) in monocytes, fibroblasts, endothelial cells, and mammary epithelial cells through NF-KappaB sites in their promoters

Go back
485.0, 1013.0
21.0, 21.0

p13

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m185*0.1

nodelay

--

true

0

false

PMID: 7744810,2217207 IL-1 and TNF-alpha stimulate the expression of many of the alpha-chemokines including GROalpha, GRObeta (MIP-2alpha), and GROgamma (MIP-2 beta) in monocytes, fibroblasts, endothelial cells, and mammary epithelial cells through NF-KappaB sites in their promoters

Go back
594.0, 1038.0
19.0, 19.0

p13

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m185*0.1

nodelay

--

true

0

false

PMID: 7744810,2217207 IL-1 and TNF-alpha stimulate the expression of many of the alpha-chemokines including GROalpha, GRObeta (MIP-2alpha), and GROgamma (MIP-2 beta) in monocytes, fibroblasts, endothelial cells, and mammary epithelial cells through NF-KappaB sites in their promoters

Go back
954.0, 1066.0
19.0, 19.0

p19

p19

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m4356*0.1

nodelay

--

true

0

false

PMID: 7744810,7584498,7929219,8083342 ENA-78, one of the neutrophil attractant chemokines, is produced and secreted by epithelial cells in response to IL-1beta or TNF-alpha, along with IL-8, GROalpha, and GROgamma.

Go back
522.0, 750.0
19.0, 19.0

p2

p2

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c20 : 1
stoichiometry:c4 : 1

m185*0.1

nodelay

--

true

0

false

PMID: 7744810,7584498,3260265 Numerous exogenous agents and endogenous proinflammatory stimulants, such as endotoxin, lectins, hypoxia, viruses, bacteria, IL-1, and TNF-alpha, stimulate IL-8 production in a wide variety of cell types,by stabilization of IL-8 mRNA as well as by activation of IL-8 gene transcription PMID: 7744810 Analysis of the IL-8 promoter showed that the sequences between positions -91 and -71 contain the NF-KappaB-binding site and the NF-IL-6 (or C/EBP) site and are sufficient for the induction of IL-8 gene transcription by LPS, IL-1, TNF-alpha, phorbol 12-myristate 13-acetate, or hepatitis B virus protein X. PMID: 7744810 Glucocorticoids, such as dexamethasone, are potent immunomodulating anti-inflammatory agents that have a marked inhibitory effect on the gene transcription of several proinflammatory cytokines including IL-1, TNF-alpha, and IL-8. PMID: 7744810,8175759 However, dexamethasone also suppresses IL-1-induced IL-8 production through the NF-kappaB site

Go back
962.0, 1030.0
19.0, 19.0

p20

p20

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c50 : 1
stoichiometry:c47 : 1

m21*m230*0.1

nodelay

--

true

0

false

PMID: 7744810,7584498,7929219,8083342 ENA-78, one of the neutrophil attractant chemokines, is produced and secreted by epithelial cells in response to IL-1beta or TNF-alpha, along with IL-8, GROalpha, and GROgamma

Go back
958.0, 946.0
19.0, 19.0

p20

p21

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m1591*m21*0.1

nodelay

--

true

0

false

PMID: 7744810,7584498,7929219,8083342 ENA-78, one of the neutrophil attractant chemokines, is produced and secreted by epithelial cells in response to IL-1beta or TNF-alpha, along with IL-8, GROalpha, and GROgamma

Go back
410.0, 1118.0
19.0, 19.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c56 : 1
stoichiometry:c55 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 7744810,8454640 IFN-gamma induces IP-10 expression through an ISRE element present in the region flanking the transcription start site PMID: 7744810,8051417 IL-4 can inhibit IFN-gamma induction by activation of a negative regulator that competes for the ISRE site

Go back
642.0, 1090.0
19.0, 19.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 7744810,8355682 NF-IL-6 (C/EPB), NF-KappaB, and c-Ets sites have been identified in the promoter for MIP-1alpha

Go back
690.0, 1102.0
19.0, 19.0

p23

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m157177*0.1

nodelay

--

true

0

false

PMID: 7744810,8355682 NF-IL-6 (C/EPB), NF-KappaB, and c-Ets sites have been identified in the promoter for MIP-1alpha

Go back
757.0, 801.0
21.0, 21.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 7744810 Studies of the regulation of neutrophil expression of CCRs show that a 30-min incubation of neutrophils with granulocyte-macrophage colony-stimulating factor down-regulates the expression of IL-8R and C5a receptor (C5aR) and up-regulates fMLP receptor (fMLPR) expression

Go back
817.0, 933.0
21.0, 21.0

p25

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 7744810 Studies of the regulation of neutrophil expression of CCRs show that a 30-min incubation of neutrophils with granulocyte-macrophage colony-stimulating factor down-regulates the expression of IL-8R and C5a receptor (C5aR) and up-regulates fMLP receptor (fMLPR) expression

Go back
697.0, 753.0
21.0, 21.0

p25

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 7744810 Studies of the regulation of neutrophil expression of CCRs show that a 30-min incubation of neutrophils with granulocyte-macrophage colony-stimulating factor down-regulates the expression of IL-8R and C5a receptor (C5aR) and up-regulates fMLP receptor (fMLPR) expression

Go back
821.0, 985.0
21.0, 21.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 7744810 In addition, in vitro incubation of neutrophils with granulocyte colony-stimulating factor enhances, whereas LPS inhibits, the expression of IL-8R mRNA, IL-8 binding, and chemotactic responses by neutrophils

Go back
769.0, 837.0
21.0, 21.0

p28

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 7744810 In addition, in vitro incubation of neutrophils with granulocyte colony-stimulating factor enhances, whereas LPS inhibits, the expression of IL-8R mRNA, IL-8 binding, and chemotactic responses by neutrophils

Go back
438.0, 806.0
19.0, 19.0

p2

p3

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c21 : 1
stoichiometry:c33 : 1
stoichiometry:c6 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 7744810,7584498,3260265 Numerous exogenous agents and endogenous proinflammatory stimulants, such as endotoxin, lectins, hypoxia, viruses, bacteria, IL-1, and TNF-alpha, stimulate IL-8 production in a wide variety of cell types,by stabilization of IL-8 mRNA as well as by activation of IL-8 gene transcription PMID: 7744810 Analysis of the IL-8 promoter showed that the sequences between positions -91 and -71 contain the NF-KappaB-binding site and the NF-IL-6 (or C/EBP) site and are sufficient for the induction of IL-8 gene transcription by LPS, IL-1, TNF-alpha, phorbol 12-myristate 13-acetate, or hepatitis B virus protein X. PMID: 7744810 Glucocorticoids, such as dexamethasone, are potent immunomodulating anti-inflammatory agents that have a marked inhibitory effect on the gene transcription of several proinflammatory cytokines including IL-1, TNF-alpha, and IL-8. PMID: 7744810,8035808 Interferon- beta also appears to regulate inflammatory cytokine transcription as it inhibits TNF-alpha-induced IL-8 gene expression at the transcriptional level via the NF-KappaB site

Go back
761.0, 889.0
21.0, 21.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m157177*0.1

nodelay

--

true

0

false

PMID: 7744810 In contrast, LPS up-regulates the expression of neutrophil fMLP receptors by increasing gene transcription

Go back
101.0, 677.0
21.0, 21.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m2120*m30*0.1

nodelay

--

true

0

false

PMID: 7744810 Studies on IL-8RA and IL-8RB show that although both receptors bind IL-8 with similar affinities, the ligand-receptor interaction to each of the receptors is mediated through different regions of IL-8.

Go back
89.0, 797.0
21.0, 21.0

p31

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m32*m2120*0.1

nodelay

--

true

0

false

PMID: 7744810 Studies on IL-8RA and IL-8RB show that although both receptors bind IL-8 with similar affinities, the ligand-receptor interaction to each of the receptors is mediated through different regions of IL-8.

Go back
402.0, 78.0
19.0, 19.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m34*m249*0.1

nodelay

--

true

0

false

PMID: 7744810 The best characterized signal transduction pathway of G protein-coupled receptors starts with ligand binding, followed by activation of a heterotrimeric G protein.

Go back
513.0, 201.0
21.0, 21.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m35*m250*0.1

nodelay

--

true

0

false

PMID: 7744810 The best characterized signal transduction pathway of G protein-coupled receptors starts with ligand binding, followed by activation of a heterotrimeric G protein.

Go back
573.0, 245.0
21.0, 21.0

p35

p35

cso30:i:ME_GDP-GTPExchange

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 7744810 An exchange occurs in the alpha subunit of the G protein from a GDP- to a GTP-bound state, resulting in a dissociation of the alpha subunit from the beta-gamma subunits

Go back
677.0, 297.0
21.0, 21.0

p36

p36

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 7744810 An exchange occurs in the alpha subunit of the G protein from a GDP- to a GTP-bound state, resulting in a dissociation of the alpha subunit from the beta-gamma subunits

Go back
853.0, 297.0
21.0, 21.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m37*m1237*0.1

nodelay

--

true

0

false

PMID: 7744810 The free alpha subunit can activate both phospholipase C (PLCbeta) 1 and PLCbeta2, whereas the free beta-gamma complex activates preferentially PLCbeta2.

Go back
721.0, 333.0
21.0, 21.0

p37

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c93 : 1

m37*m3586*0.1

nodelay

--

true

0

false

PMID: 7744810 The free alpha subunit can activate both phospholipase C (PLCbeta) 1 and PLCbeta2, whereas the free beta-gamma complex activates preferentially PLCbeta2.

Go back
578.0, 434.0
19.0, 19.0

p39

p39

cso30:i:ME_Hydrolysis

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m41*m290229*0.1

nodelay

--

true

0

false

PMID: 7744810 The activation of PLCs results in hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two second messengers: inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DG).

Go back
557.0, 853.0
21.0, 21.0

p4

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c25 : 1
stoichiometry:c8 : 1

m157177*0.1

nodelay

--

true

0

false

PMID: 7744810 Analysis of the IL-8 promoter showed that the sequences between positions -91 and -71 contain the NF-KappaB-binding site and the NF-IL-6 (or C/EBP) site and are sufficient for the induction of IL-8 gene transcription by LPS, IL-1, TNF-alpha, phorbol 12-myristate 13-acetate, or hepatitis B virus protein X. PMID: 7744810 Glucocorticoids, such as dexamethasone, are potent immunomodulating anti-inflammatory agents that have a marked inhibitory effect on the gene transcription of several proinflammatory cytokines including IL-1, TNF-alpha, and IL-8.

Go back
822.0, 426.0
19.0, 19.0

p39

p40

cso30:i:ME_Hydrolysis

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m40*m290229*0.1

nodelay

--

true

0

false

PMID: 7744810 The activation of PLCs results in hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two second messengers: inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DG).

Go back
473.0, 349.0
21.0, 21.0

p37

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m38*m3586*0.1

nodelay

--

true

0

false

PMID: 7744810 The free alpha subunit can activate both phospholipase C (PLCbeta) 1 and PLCbeta2, whereas the free beta-gamma complex activates preferentially PLCbeta2.

Go back
429.0, 425.0
21.0, 21.0

p42

p42

cso30:i:ME_ChangeInMaterialConcentration

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 7744810,1314560,8304236,1902986 IP3 mobilizes Ca2+ from intracellular stores leading to a transient rise in [Ca2+], whereas DG stimulates PKC

Go back
833.0, 473.0
21.0, 21.0

p43

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m43*m92*0.1

nodelay

--

true

0

false

PMID: 7744810,1314560,8304236,1902986 IP3 mobilizes Ca2+ from intracellular stores leading to a transient rise in [Ca2+], whereas DG stimulates PKC

Go back
413.0, 545.0
21.0, 21.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c112 : 1
stoichiometry:c115 : 1
stoichiometry:c120 : 1

m45*m119*m44*0.1

nodelay

--

true

0

false

PMID: 7744810,2104616 Moreover, activation of PKC and elevation in cytosolic Ca2+ can thereafter induce PLC and phospholipase D (PLD) to yield DG and phosphatidic acid, respectively, resulting in a positive feedback loop

Go back
605.0, 557.0
21.0, 21.0

p44

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c118 : 1
stoichiometry:c117 : 1
stoichiometry:c119 : 1
stoichiometry:c121 : 1

m44*m47*m45*0.1

nodelay

--

true

0

false

PMID: 7744810,2104616 Moreover, activation of PKC and elevation in cytosolic Ca2+ can thereafter induce PLC and phospholipase D (PLD) to yield DG and phosphatidic acid, respectively, resulting in a positive feedback loop

Go back
554.0, 630.0
19.0, 19.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m2120*m47*0.1

nodelay

--

true

0

false

PMID: 7744810,7949145 PLD activation was also shown to be induced by IL-8, fMLP, C5a, PAF, and LTB4.

Go back
557.0, 1177.0
21.0, 21.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m69*m70*m166*0.1

nodelay

--

true

0

false

PMID: 7744810,8413306,8207232 Studies on Jurkat and HeLa cells showed that the IL-8 gene is regulated by a cooperative binding to the DNA of the C/EBP binding-protein (NF-IL-6) and the NF-B-binding protein (RelA)

Go back
310.0, 462.0
19.0, 19.0

p46

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m138859*m47*0.1

nodelay

--

true

0

false

PMID: 7744810,7949145 PLD activation was also shown to be induced by IL-8, fMLP, C5a, PAF, and LTB4.

Go back
690.0, 654.0
19.0, 19.0

p46

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m12280*m47*0.1

nodelay

--

true

0

false

PMID: 7744810,7949145 PLD activation was also shown to be induced by IL-8, fMLP, C5a, PAF, and LTB4.

Go back
378.0, 1006.0
19.0, 19.0

p2

p5

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c23 : 1
stoichiometry:c10 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 7744810,7584498,3260265 Numerous exogenous agents and endogenous proinflammatory stimulants, such as endotoxin, lectins, hypoxia, viruses, bacteria, IL-1, and TNF-alpha, stimulate IL-8 production in a wide variety of cell types,by stabilization of IL-8 mRNA as well as by activation of IL-8 gene transcription PMID: 7744810 Glucocorticoids, such as dexamethasone, are potent immunomodulating anti-inflammatory agents that have a marked inhibitory effect on the gene transcription of several proinflammatory cytokines including IL-1, TNF-alpha, and IL-8.

Go back
834.0, 514.0
19.0, 19.0

p46

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m63*m47*0.1

nodelay

--

true

0

false

PMID: 7744810,7949145 PLD activation was also shown to be induced by IL-8, fMLP, C5a, PAF, and LTB4.

Go back
890.0, 530.0
19.0, 19.0

p46

p51

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m64*m47*0.1

nodelay

--

true

0

false

PMID: 7744810,7949145 PLD activation was also shown to be induced by IL-8, fMLP, C5a, PAF, and LTB4.

Go back
794.0, 650.0
19.0, 19.0

p52

p52

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1

m2120*m92*0.1

nodelay

--

true

0

false

PMID: 7744810,8144937,8034695,8376383 Activation of PKC and a number of additional serine/threonine kinases was demonstrated in response to IL-8, fMLP, MCP-1, MCP-2, and MCP-3

Go back
366.0, 370.0
19.0, 19.0

p52

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m138859*m92*0.1

nodelay

--

true

0

false

PMID: 7744810,8144937,8034695,8376383 Activation of PKC and a number of additional serine/threonine kinases was demonstrated in response to IL-8, fMLP, MCP-1, MCP-2, and MCP-3

Go back
922.0, 338.0
19.0, 19.0

p52

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m2133*m92*0.1

nodelay

--

true

0

false

PMID: 7744810,8144937,8034695,8376383 Activation of PKC and a number of additional serine/threonine kinases was demonstrated in response to IL-8, fMLP, MCP-1, MCP-2, and MCP-3

Go back
946.0, 374.0
19.0, 19.0

p52

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m4422*m92*0.1

nodelay

--

true

0

false

PMID: 7744810,8144937,8034695,8376383 Activation of PKC and a number of additional serine/threonine kinases was demonstrated in response to IL-8, fMLP, MCP-1, MCP-2, and MCP-3

Go back
946.0, 594.0
19.0, 19.0

p52

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m4426*m92*0.1

nodelay

--

true

0

false

PMID: 7744810,8144937,8034695,8376383 Activation of PKC and a number of additional serine/threonine kinases was demonstrated in response to IL-8, fMLP, MCP-1, MCP-2, and MCP-3

Go back
1102.0, 174.0
19.0, 19.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m12280*m6571*0.1

nodelay

--

true

0

false

--

Go back
935.0, 215.0
17.0, 17.0

p58

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m65*m120*0.1

nodelay

--

true

0

false

PMID: 7744810,8090790 Buhl et al,have proposed a model for the C5aR-induced signal transduction network in human polymorphonuclear leukocytes, proceeding from PLC through PKC to stimulation of the MAP kinase pathway.

Go back
799.0, 379.0
17.0, 17.0

p58

p59

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c160 : 1
stoichiometry:c159 : 1

m92*m66*0.1

nodelay

--

true

0

false

PMID: 7744810,8090790 Buhl et al,have proposed a model for the C5aR-induced signal transduction network in human polymorphonuclear leukocytes, proceeding from PLC through PKC to stimulation of the MAP kinase pathway.

Go back
254.0, 762.0
19.0, 19.0

p1

p6

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 7744810,7584498,3260265 Numerous exogenous agents and endogenous proinflammatory stimulants, such as endotoxin, lectins, hypoxia, viruses, bacteria, IL-1, and TNF-alpha, stimulate IL-8 production in a wide variety of cell types,by stabilization of IL-8 mRNA as well as by activation of IL-8 gene transcription

Go back
911.0, 611.0
17.0, 17.0

p58

p60

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m45*m67*0.1

nodelay

--

true

0

false

PMID: 7744810,8090790 Buhl et al,have proposed a model for the C5aR-induced signal transduction network in human polymorphonuclear leukocytes, proceeding from PLC through PKC to stimulation of the MAP kinase pathway.

Go back
494.0, 954.0
19.0, 19.0

p2

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c24 : 1
stoichiometry:c14 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 7744810,7584498,3260265 Numerous exogenous agents and endogenous proinflammatory stimulants, such as endotoxin, lectins, hypoxia, viruses, bacteria, IL-1, and TNF-alpha, stimulate IL-8 production in a wide variety of cell types,by stabilization of IL-8 mRNA as well as by activation of IL-8 gene transcription PMID: 7744810 Glucocorticoids, such as dexamethasone, are potent immunomodulating anti-inflammatory agents that have a marked inhibitory effect on the gene transcription of several proinflammatory cytokines including IL-1, TNF-alpha, and IL-8.

Go back
569.0, 921.0
21.0, 21.0

p4

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c26 : 1
stoichiometry:c16 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 7744810 Analysis of the IL-8 promoter showed that the sequences between positions -91 and -71 contain the NF-KappaB-binding site and the NF-IL-6 (or C/EBP) site and are sufficient for the induction of IL-8 gene transcription by LPS, IL-1, TNF-alpha, phorbol 12-myristate 13-acetate, or hepatitis B virus protein X. PMID: 7744810 Glucocorticoids, such as dexamethasone, are potent immunomodulating anti-inflammatory agents that have a marked inhibitory effect on the gene transcription of several proinflammatory cytokines including IL-1, TNF-alpha, and IL-8.

Go back
645.0, 917.0
21.0, 21.0

p4

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c27 : 1
stoichiometry:c18 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 7744810 Analysis of the IL-8 promoter showed that the sequences between positions -91 and -71 contain the NF-KappaB-binding site and the NF-IL-6 (or C/EBP) site and are sufficient for the induction of IL-8 gene transcription by LPS, IL-1, TNF-alpha, phorbol 12-myristate 13-acetate, or hepatitis B virus protein X. PMID: 7744810 Glucocorticoids, such as dexamethasone, are potent immunomodulating anti-inflammatory agents that have a marked inhibitory effect on the gene transcription of several proinflammatory cytokines including IL-1, TNF-alpha, and IL-8.

Go back
128.0, 496.0

c1

c1

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
390.0, 906.7568569044405

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
840.7259714626609, 388.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
518.0, 413.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
540.9128911033334, 438.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.5316298465008, 440.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.5153777348837, 329.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
502.0, 360.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
494.0, 362.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
456.67966563693466, 447.40250689707057

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
388.0, 436.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
674.0, 485.65191270643953

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
279.4232816139664, 783.7687999861266

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
861.1302242460887, 450.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
779.0843778027024, 490.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
374.0, 448.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
441.97254145195257, 529.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
368.0, 539.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
434.0, 564.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
380.0, 442.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
633.7181105699019, 532.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
545.0, 574.6428033978249

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
626.0, 577.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
114.89546304620545, 747.2890551912172

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
434.0, 505.9044164637172

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
626.0, 570.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
107.0, 643.7465375613175

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
542.0, 605.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
573.0, 623.3423947843869

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
121.0, 319.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
335.93297965499335, 480.99171555893554

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
329.0, 476.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
716.3012697416892, 484.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
545.0, 600.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
115.0, 952.0

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
684.9088269514548, 635.9800481275978

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
859.759841579916, 368.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
545.0, 527.8323146698044

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
691.9488132492752, 530.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
916.0245844997962, 432.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
545.0, 543.2147351682427

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.5364272835136, 544.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
107.0, 661.9481461829184

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
813.8636641392111, 456.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
766.5504924049891, 547.5825449878054

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.9368211420091, 904.3622900637502

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
121.0, 314.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
392.9467408360067, 381.9215802110198

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
385.0, 383.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.1554175279994, 272.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
925.0, 364.9738323849174

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
777.5272873522841, 357.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
972.5036344841974, 320.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
931.0, 400.07934577905587

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
778.4441682085866, 391.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
972.4278135270821, 544.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
597.5397291349389, 751.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
926.0, 456.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
779.4656584691869, 535.8747075714685

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1112.0, 201.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1042.0, 170.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.6024580899987, 191.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
959.9316343643403, 226.0436361005711

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
887.0, 225.99227787671367

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
932.9402850002907, 232.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
823.2003151453434, 395.48646838616634

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
766.6059665643729, 396.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
447.72086630883007, 896.0948086884423

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.1558498630382, 298.0

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
772.0, 535.0

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
879.0, 627.3954710098458

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
910.2942002165319, 628.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
466.0, 1176.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
487.0, 1193.398612773923

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.0, 1188.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
578.0, 1194.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
673.7271823306008, 810.0

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
447.8858914040833, 892.3463717031361

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.8244673310502, 879.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
119.0, 628.0

c2

c2

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
122.0, 404.0

c20

c20

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
118.0, 404.0

c21

c21

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
114.0, 404.0

c22

c22

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
113.0, 404.0

c23

c23

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
116.0, 404.0

c24

c24

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
120.0, 404.0

c25

c25

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
118.0, 404.0

c26

c26

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
120.0, 404.0

c27

c27

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
119.0, 404.0

c28

c28

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
124.0, 404.0

c29

c29

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
389.0, 906.1833657818158

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.0, 758.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
126.0, 404.0

c31

c31

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
646.0, 754.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
116.0, 823.9926701495251

c33

c33

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
120.0, 561.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
374.0, 1054.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
125.0, 560.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.3995009355511, 994.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
125.0, 560.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
653.0, 1013.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
435.25219582418725, 769.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
124.0, 500.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
448.0, 1018.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
125.0, 500.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
506.0, 1032.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
126.0, 500.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.0, 1050.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
798.0, 1047.2159204962816

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
922.1927794053147, 1049.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.0, 1091.0740528189224

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
973.0, 1076.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
125.0, 559.0

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
125.0, 557.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
985.0, 956.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
791.0, 970.325994818112

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
917.3593175009767, 965.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
118.0, 1070.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
429.0, 1128.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
117.0, 1129.2045103337564

c56

c56

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
118.0, 1069.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
653.0, 1109.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
714.305592083077, 663.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
426.87183263447093, 825.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.6568542494924, 1121.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
781.3030813089294, 596.0

c61

c61

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
708.5258631286023, 820.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
838.4075761787336, 596.0

c63

c63

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
746.5498566259299, 952.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
725.2897559784257, 594.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
711.0, 774.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
849.9807497790049, 997.554646702788

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.1416077918096, 891.1264660080394

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
793.4358825577748, 659.0

c69

c69

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
585.445488720644, 656.0

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
716.7611400011626, 851.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.4317113711047, 660.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
736.22846762196, 842.7911752716327

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
99.0, 705.6921915811266

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
129.53771752223312, 694.6800773412384

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
119.0, 698.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
117.76857354483045, 812.9103049700403

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
97.0, 755.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
110.0, 817.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
343.0, 88.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
447.8965554002117, 866.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 100.97115768801635

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
421.0, 96.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
493.0, 166.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
438.0, 212.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.622181616751, 222.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.0, 261.1659646153463

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
594.0, 256.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.0, 265.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
698.0, 308.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
599.9214490724734, 310.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
114.0, 896.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
812.0, 308.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
804.0, 268.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
864.0, 318.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
726.9684350024883, 354.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
749.1813408844941, 312.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
665.0, 347.54196243224743

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.7196711294724, 411.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
518.0, 416.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
540.0588235294117, 449.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
597.0, 451.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back