1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/8699127.csml convertedTime:2009.07.01.11:23

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Endotoxin signal transduction in macrophages.
Authors Sweet MJ, Hume DA.
Affiliation Centre for Molecular and Cellular Biology, University of Queensland, Brisbane,Australia.
Abstract Through its action on macrophages, bacterial lipopolysaccharide (LPS) orendotoxin can trigger responses that are protective or injurious to the host.This review examines the effects of LPS on macrophages by following events fromthe cell surface to the nucleus. The involvement of protein tyrosine kinases,mitogen-activated protein kinases, protein kinase C, G proteins, protein kinaseA, ceramide-activated protein kinase, and microtubules in this process arereviewed. At the nuclear level, rel, C/EBP, Ets, Egr, fos, and jun familymembers have been implicated in activation of LPS-inducible gene expression.
PMID 8699127
Model Abstract

Entity

G010214:c-fos G010232:c-jun G010329:TNF-alpha G010389:IL-1beta G010435:CSF1R G010492:CD11b G010514:iNOS G010625:Egr1 G012405:JUNB MO000000015:Raf-1 MO000000022:p38 MO000000038:Elk-1 MO000000104:PKC MO000000132:PLC MO000000145:Jak1 MO000000146:Jak2 MO000000199:p105 MO000000214:IL-1 MO000000276:AP-1 MO000000289:TNF-alpha MO000004670:ERK1 MO000004676:ERK2 MO000007685:IRF-1 MO000007828:JunB MO000013119:STAT1 MO000016597:IL-1beta MO000016882:LPS MO000017190:Egr-1 MO000017284:c-Ets-2 MO000018132:CD14 MO000019420:LBP MO000019704:STAT1{p} MO000021928:LPS:LBP MO000021929:LPS:LBP:CD14 MO000037579:PU.1 MO000038021:LynA MO000038022:LynB MO000038364:Elk-1{p} MO000038411:Raf-1{p} MO000090473:MARCKS MO000100032:NF-kappaB1 e1: e10: e11:LynA{p} e12:LynB{p} e13:p58HCK e14:p58HCK{p} e15:p64HCK e16:p64HCK{p} e17:c-fgr e18:c-fgr{p} e19:MAPK e2: e20:MAPK{active} e21:RSK6 e22:RSK6{p} e23:PLC{active} e24:CSF1 e25:CSF1R e26:CSF1:CSF1R e27:ERK1{active} e28:ERK2 e29:p38{p} e3: e30:PKC{active} e31:MARCKS{active} e32:MacMARCKS e33:MacMARCKS{active} e34:LPS:PKC e35:muramyl dipeptide e36:muramyl dipeptide:PKC e37:CAK e38:CAK{active} e39:ceramide e4: e40:IL-1 e41:PT e42:Nitric oxide e43:membrane protein e44:membrane protein{adp-ribose} e45:MAP2 e46:LPS:MAP2 e47:taxol e48:MAP2{p} e49:c-Ets-2{active} e5:CD11c:CD18 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS:CD11c:CD18 e60: e61: e62: e63:genestein e64:MIP-1alpha e65:FcgammaR1b e66:TFIID e67:PU.1:TFIID e68:PKA{active} e69:PKA e7: e70:H7 e71:PMA e72:NFkappaB:IkappaB e73:IkappaB e74:protein remnants e75:IkappaB{p}:NF-kappaB e76:NF-kappaB e77:NFIL6 e78:NF-IL6 e79:NF-IL6{p} e8: e80:NF-kappaB:NF-IL6 e81:AP-1:NF-IL6 e82:IFN-gamma e83:IFN-gammaR e84:IFNgamma:IFNgammaR e85:IFNgamma:IFNgammaR:JAK1 e86:IFNgamma:IFNgammaR:JAK2 e87:Stat1{p}:Stat1{p} e88:Stat1{p}:Stat1{p} e89:IRF-1 e9: e90:IRF-9 e91:IRF-9{active} e92:DNA

Process

p1 p10 p11 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p9
Model Detail
494.0, 1046.0
36.0, 36.0

c-fos

--

G010214

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p54

--

true true true true

csml-variable:Double

m93203

10

false

infinite

0

unit false false false
TRANSFACG010214

--

Go back
854.0, 1266.0
36.0, 36.0

c-jun

--

G010232

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p52

--

true true true true

csml-variable:Double

m93221

10

false

infinite

0

unit false false false
TRANSFACG010232

--

Go back
842.0, 1070.0
36.0, 36.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p22 p26 p76 p78

p24 p77 p79

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
717.0, 1093.0
46.0, 46.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p23 p44

p25

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
615.0, 1011.0
42.0, 42.0

CSF1R

--

G010435

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p48

--

true true true true

csml-variable:Double

m93406

10

false

infinite

0

unit false false false
TRANSFACG010435

--

Go back
835.0, 1307.0
42.0, 42.0

CD11b

--

G010492

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p46

--

true true true true

csml-variable:Double

m93458

10

false

infinite

0

unit false false false
TRANSFACG010492

--

Go back
711.0, 1163.0
42.0, 42.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p75

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
564.0, 1156.0
40.0, 40.0

Egr1

--

G010625

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p55

p56

true true true true

csml-variable:Double

m93569

10

false

infinite

0

unit false false false
TRANSFACG010625

--

Go back
778.0, 1226.0
36.0, 36.0

JUNB

--

G012405

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p50

p51

true true true true

csml-variable:Double

m95154

10

false

infinite

0

unit false false false
TRANSFACG012405

--

Go back
962.0, 405.0
34.0, 34.0

Raf-1

--

MO000000015

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p19 p32

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000015

--

Go back
625.0, 505.0
30.0, 30.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
845.0, 773.0
38.0, 38.0

Elk-1

--

MO000000038

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m65

10

false

infinite

0

unit false false false
InterProIPR002341
TRANSPATHMO000000038

--

Go back
902.0, 194.0
36.0, 36.0

PKC

--

MO000000104

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p29 p30

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
647.0, 279.0
34.0, 34.0

PLC

--

MO000000132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m119

10

false

infinite

0

unit false false false
TRANSPATHMO000000132

--

Go back
713.0, 1457.0
38.0, 38.0

Jak1

--

MO000000145

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p67

true true true true

csml-variable:Double

m129

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000145

--

Go back
903.0, 1423.0
34.0, 34.0

Jak2

--

MO000000146

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p68

true true true true

csml-variable:Double

m130

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000146

--

Go back
403.0, 291.0
34.0, 34.0

p105

--

MO000000199

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m171

10

false

infinite

0

unit false false false
TRANSPATHMO000000199

--

Go back
1189.0, 1177.0
38.0, 38.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

--

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
1124.0, 948.0
40.0, 40.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
1226.0, 1026.0
36.0, 36.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24 p77 p79

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
330.0, 338.0
36.0, 36.0

ERK1

--

MO000004670

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p16

true true true true

csml-variable:Double

m549

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
320.0, 652.0
32.0, 32.0

ERK2

--

MO000004676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p18

true true true true

csml-variable:Double

m554

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
557.0, 1409.0
38.0, 38.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
1186.0, 1262.0
44.0, 44.0

JunB

--

MO000007828

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51

--

true true true true

csml-variable:Double

m999

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000007828

--

Go back
1005.0, 1477.0
38.0, 38.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p69 p70

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
1245.0, 1117.0
38.0, 38.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
1682.0, 170.0
28.0, 28.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p3 p29 p38

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
257.0, 1249.0
38.0, 38.0

Egr-1

--

MO000017190

cso30:c:Protein

cso30:i:CC_CellComponent

--

p56

--

true true true true

csml-variable:Double

m2058

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000017190

--

Go back
408.0, 936.0
32.0, 32.0

c-Ets-2

--

MO000017284

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m2137

10

false

infinite

0

unit false false false
InterProIPR002341
TRANSPATHMO000017284

--

Go back
1393.0, 209.0
37.0, 37.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
1485.0, 217.0
30.0, 30.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
1220.0, 1476.0
40.0, 40.0

STAT1{p}

--

MO000019704

cso30:c:Protein

cso30:i:CC_CellComponent

--

p69 p70

p71

true true true true

csml-variable:Double

m4238

10

false

infinite

0

unit false false false
TRANSPATHMO000019704

--

Go back
1552.0, 280.0
32.0, 32.0

LPS:LBP

--

MO000021928

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p2

true true true true

csml-variable:Double

m6254

10

false

infinite

0

unit false false false
TRANSPATHMO000021928

--

Go back
1387.0, 275.0
42.0, 42.0

LPS:LBP:CD14

--

MO000021929

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p4 p5 p6 p7 p8 p9 p11 p13 p16 p18 p20 p21 p26 p27 p28 p31 p34 p35 p36 p40 p42 p43 p52 p53 p54 p55 p56 p57 p58 p61 p75

true true true true

csml-variable:Double

m6255

10

false

infinite

0

unit false false false
TRANSPATHMO000021929

--

Go back
572.0, 1304.0
32.0, 32.0

PU.1

--

MO000037579

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44 p45 p46 p47 p48 p49

true true true true

csml-variable:Double

m15836

10

false

infinite

0

unit false false false
InterProIPR002341
TRANSPATHMO000037579

--

Go back
1145.0, 217.0
30.0, 30.0

LynA

--

MO000038021

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m16258

10

false

infinite

0

unit false false false
TRANSPATHMO000038021

--

Go back
1194.0, 325.0
34.0, 34.0

LynB

--

MO000038022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m16259

10

false

infinite

0

unit false false false
TRANSPATHMO000038022

--

Go back
878.0, 882.0
36.0, 36.0

Elk-1{p}

--

MO000038364

cso30:c:Protein

cso30:i:CC_CellComponent

--

p43

--

true true true true

csml-variable:Double

m16574

10

false

infinite

0

unit false false false
TRANSPATHMO000038364

--

Go back
959.0, 535.0
34.0, 34.0

Raf-1{p}

--

MO000038411

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9 p19 p32

p10

true true true true

csml-variable:Double

m16621

10

false

infinite

0

unit false false false
TRANSPATHMO000038411

--

Go back
1067.0, 631.0
34.0, 34.0

MARCKS

--

MO000090473

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m64002

10

false

infinite

0

unit false false false
TRANSPATHMO000090473

--

Go back
428.0, 440.0
32.0, 32.0

NF-kappaB1

--

MO000100032

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57

p59

true true true true

csml-variable:Double

m73069

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000100032

--

Go back
162.7551080106781, 78.4017745537845
1297.1274955284903, 1564.5345374919139

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
227.13594086614398, 115.17788148142095
1144.9498567286091, 1337.9184309809398

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1126.0, 272.29268292682923
34.63414634146343, 27.70731707317074

LynA{p}

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1126.0, 377.80487804878055
35.2439024390244, 28.195121951219516

LynB{p}

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1188.0, 434.28285369289586
37.649426443952514, 23.21714630710405

p58HCK

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1142.0, 493.4390243902441
41.95121951219511, 33.56097560975611

p58HCK{p}

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1162.0, 532.6096800160998
41.98430267659489, 25.89031998390018

p64HCK

--

e15

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1181.0, 595.4390243902438
36.951219512195124, 29.560975609756092

p64HCK{p}

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1168.0, 635.227711813242
40.9820889514993, 25.2722881867579

c-fgr

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1198.0, 722.4634146341465
43.170731707317074, 34.53658536585366

c-fgr{p}

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

p8

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
839.0, 596.3
41.599999999999994, 31.200000000000006

MAPK

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10 p39 p40

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
162.7551080106781, 78.4017745537845
1297.1274955284903, 1564.5345374919139

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1095.0, 596.3
41.6, 31.200000000000003

MAPK{active}

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

p10 p39 p40

p11 p41

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
876.0, 717.4525055343128
47.104045079492856, 29.04749446568726

RSK6

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1039.0, 715.9268292682926
41.341463414634156, 33.07317073170732

RSK6{p}

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

p11

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
699.0, 407.0
34.0, 34.0

PLC{active}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

p48

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000132

--

Go back
61.0, 556.9991212653779
46.924428822495614, 30.50087873462214

CSF1

--

e24

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p14

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
208.5, 490.0
39.0, 60.0

CSF1R

--

e25

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p14

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
208.5, 630.0
31.0, 60.0

CSF1:CSF1R

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

p15 p17 p19

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
329.0, 501.0
38.0, 38.0

ERK1{active}

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15 p16

--

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
316.0, 796.0
32.0, 32.0

ERK2

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p18

--

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
625.0, 665.0
30.0, 30.0

p38{p}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

--

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
188.69765792124792, 99.9518370536732
1245.2423957073506, 1521.4344124921377

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
798.0, 410.0
36.0, 36.0

PKC{active}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

p22 p23 p25 p63 p79

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
1081.0, 781.0
29.0, 29.0

MARCKS{active}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27

--

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000090473

--

Go back
1160.5, 769.8116321191387
22.316160193197828, 36.18836788086134

MacMARCKS

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p28

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1159.5, 908.7929160796942
24.1777017508553, 39.207083920305905

MacMARCKS{active}

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

p28

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1012.5, 265.19613397767034
30.056490584902512, 36.8038660223296

LPS:PKC

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
846.0, 27.471825063078214
59.167367535744326, 33.528174936921786

muramyl dipeptide

--

e35

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p30

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
819.5, 195.45675720713214
33.11031494750875, 40.54324279286786

muramyl dipeptide:PKC

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
430.0, 231.1
35.2, 26.399999999999995

CAK

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31 p33

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
551.0, 314.1
39.2, 29.400000000000002

CAK{active}

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

p31 p33

p32

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
326.0, 259.0
60.0, 34.0

ceramide

--

e39

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p33

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
236.6913752558021, 137.664446428478
1149.2549610382425, 1446.0091937425268

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
926.0, 1216.0
60.0, 32.0

IL-1

--

e40

cso30:c:mRNA

cso30:i:CC_NuclearChromosome

--

p34

p35

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
454.0, 791.0
60.0, 34.0

PT

--

e41

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p24 p34 p35 p36 p37 p78

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
585.0, 718.0294117647059
46.617647058823536, 27.97058823529412

Nitric oxide

--

e42

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
183.5, 869.2569933588247
32.52485409539142, 52.743006641175285

membrane protein

--

e43

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p37

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
192.5, 990.875025155967
31.52706782048702, 51.12497484403301

membrane protein{adp-ribose}

--

e44

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p37

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
658.0, 202.7533708995773
43.37291205473939, 26.74662910042262

MAP2

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p38 p41

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
523.0, 192.93370165745856
34.25966850828729, 38.06629834254144

LPS:MAP2

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
626.0, 441.5895710681245
51.90075693860387, 29.410428931875526

taxol

--

e47

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p39

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
747.0, 287.73170731707313
41.58536585365854, 33.26829268292683

MAP2{p}

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

p41

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
360.0, 1044.0
32.0, 32.0

c-Ets-2{active}

--

e49

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

--

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
InterProIPR002341
TRANSPATHMO000017284

--

Go back
1388.5, 382.0
39.0, 60.0

CD11c:CD18

--

e5

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p3

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
412.7885571080338, 900.0331178178543
692.964479848682, 522.037285349973

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
487.63388267828236, 912.4046425578084
405.1971073975535, 505.958108183136

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
421.8216136423743, 907.000761256817
674.8983667800017, 508.1019984720476

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
423.11205029013695, 908.0727064012729
672.3174934844756, 505.958108183136

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
412.7885571080338, 900.0331178178543
692.964479848682, 522.037285349973

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
412.7885571080338, 900.0331178178543
692.964479848682, 522.037285349973

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
423.11205029013695, 908.0727064012729
672.3174934844756, 505.958108183136

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
918.6397230310946, 1114.4221467090138
43.29261320478808, 32.55551128263373

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
805.0812980279584, 1264.4944669328256
122.59148153747628, 92.18728242319858

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
412.7885571080338, 900.0331178178543
692.964479848682, 522.037285349973

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1392.5, 498.0
31.0, 60.0

LPS:CD11c:CD18

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
576.1163859656168, 1132.0221737977813
21.945166872460746, 8.777166742339112

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
575.3835747261601, 1105.8465855533673
75.11315204431271, 112.31153560684972

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
606.8944580227995, 1178.8947387935948
11.724979831307332, 9.739753765363655

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
680.0, 830.3624894869638
48.77207737594618, 27.637510513036165

genestein

--

e63

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p43

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
448.0, 1134.923875432526
48.892733564013845, 26.07612456747405

MIP-1alpha

--

e64

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p45

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
504.0, 1099.1453287197232
48.477508650519034, 25.85467128027682

FcgammaR1b

--

e65

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p47

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
646.0, 1234.5
36.0, 27.0

TFIID

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p49

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
739.5, 1271.6667222129645
32.93884352607898, 40.333277787035485

PU.1:TFIID

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p49

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
395.0, 634.7259120673526
18.752104770813844, 43.27408793264733

PKA{active}

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

p53

p50 p51 p62

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
394.0, 468.8634237605238
19.992516370439663, 46.13657623947614

PKA

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p53

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
178.27442554085883, 84.13493977839794
1158.3946034490436, 1363.4974568063817

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
342.0, 1359.0
60.0, 34.0

H7

--

e70

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p55 p56

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
462.0, 1383.0
60.0, 34.0

PMA

--

e71

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p55 p56

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
559.5, 427.6168971838027
33.7962006332278, 41.3831028161973

NFkappaB:IkappaB

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p59

p58

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
451.0, 499.2969410344133
42.49144697122158, 26.20305896558664

IkappaB

--

e73

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p59

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
454.0, 642.8202182653646
36.392877656519246, 35.17978173463526

protein remnants

--

e74

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p60

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
561.5, 575.717047158807
34.53107815364106, 42.282952841193136

IkappaB{p}:NF-kappaB

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p58

p60

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
520.0, 713.02
40.63999999999999, 30.479999999999993

NF-kappaB

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

p60

p64

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
1002.0, 1164.0
60.0, 32.0

NFIL6

--

e77

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p61

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1315.0, 676.0599999999998
41.92, 31.44

NF-IL6

--

e78

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p62 p63 p64 p65

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
1313.0, 921.609756097561
45.487804878048784, 36.39024390243902

NF-IL6{p}

--

e79

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p62 p63

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
182.41291021557362, 108.1993523329325
1111.2617462527608, 1340.3519609286036

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
271.0, 872.7127071823203
34.4585635359116, 38.287292817679564

NF-kappaB:NF-IL6

--

e80

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1296.0, 1005.9779005524863
32.41988950276243, 36.02209944751381

AP-1:NF-IL6

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
782.0, 1703.2609841827766
43.44463971880492, 28.239015817223205

IFN-gamma

--

e82

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p66

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
648.5, 1574.0
39.0, 60.0

IFN-gammaR

--

e83

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p66

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
764.5, 1562.0
31.0, 60.0

IFNgamma:IFNgammaR

--

e84

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p66

p67 p68 p73 p74 p75

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
858.5, 1570.0
43.0, 60.0

IFNgamma:IFNgammaR:JAK1

--

e85

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p67

p70

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
950.5, 1570.0
43.0, 60.0

IFNgamma:IFNgammaR:JAK2

--

e86

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p68

p69

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
1275.0, 1356.3812154696134
34.75690607734807, 38.61878453038674

Stat1{p}:Stat1{p}

--

e87

cso30:c:Complex

cso30:i:CC_Cytosol

--

p71

p72

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
927.0, 1296.3812154696134
34.75690607734807, 38.61878453038674

Stat1{p}:Stat1{p}

--

e88

cso30:c:Complex

cso30:i:CC_Cytosol

--

p72

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
656.0, 1484.0
31.0, 31.0

IRF-1

--

e89

cso30:c:Protein

cso30:i:CC_CellComponent

--

p73

--

true true true true

csml-variable:Double

m93

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
193.44886934814664, 132.263764887467
1192.5002891310633, 1425.9850533093675

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
313.5, 1471.5435701348358
29.88146508351781, 48.45642986516402

IRF-9

--

e90

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p74

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
475.5, 1473.0879452606157
32.62910042262025, 52.91205473938419

IRF-9{active}

--

e91

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p74

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1494.0, 761.5
60.0, 13.0

DNA

--

e92

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p76 p77

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1580.0, 220.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019420 MO000016882

MO000021928

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3985*m155666*0.1

nodelay

--

true

0

false

PMID: 8699127 The most characterised interaction is between LPS and LPS binding protein which shares homology with the neutrophil protein bactericidal/permeability-increasing protein.

Go back
935.0, 599.0
25.0, 25.0

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e19 MO000038411

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m20*m16621*0.1

nodelay

--

true

0

false

PMID: 8699127, 7799956 Raf-1 may participate in the activation of MAPK via both ras-dependent and independent mechanisms in macrophages.

Go back
964.0, 720.0
23.0, 23.0

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e21 e20 MO000021929

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c32 : 1

m22*m21*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 7650392 One of the substrates of MAP kinase(s) is another kinase, ribosomal S6 kinase (rsk) which also becomes phosphorylated in LPS- or peptidoglycan-stimulated cells.

Go back
704.0, 328.0
23.0, 23.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000132 MO000021929

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1

m119*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 8513862 This effect appears to be phospholipase C dependent.

Go back
116.0, 612.0
23.0, 23.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e24 e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m25*m26*0.1

nodelay

--

true

0

false

Go back
337.0, 421.0
21.0, 21.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000004670 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c45 : 1
stoichiometry:c44 : 1

m549*m27*0.1

nodelay

--

true

0

false

PMID: 8699127, 8247534 CSF-1 was shown to activate the 44- (ERK-1) and 40-kDa (ERK-2) isoforms of MAPK in murine BAC-1.2F5 macrophages.

Go back
384.0, 404.0
23.0, 23.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000004670 MO000021929

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1

m549*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 7989771 LPS activated both ERK-1 and ERK-2 in BAC-1.2F5 cells and that both CSF-1 and LPS activated raf-1 through similar mechanisms.

Go back
326.0, 730.0
19.0, 19.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000004676 e26

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c53 : 1
stoichiometry:c50 : 1

m554*m27*0.1

nodelay

--

true

0

false

PMID: 8699127, 8247534 CSF-1 was shown to activate the 44- (ERK-1) and 40-kDa (ERK-2) isoforms of MAPK in murine BAC-1.2F5 macrophages.

Go back
360.0, 732.0
23.0, 23.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000004676 MO000021929

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c54 : 1
stoichiometry:c52 : 1

m554*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 7989771 LPS activated both ERK-1 and ERK-2 in BAC-1.2F5 cells and that both CSF-1 and LPS activated raf-1 through similar mechanisms.

Go back
889.0, 465.0
21.0, 21.0

p19

p19

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000015 e26

MO000038411

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1

m19*m27*0.1

nodelay

--

true

0

false

PMID: 8699127, 7989771 LPS activated both ERK-1 and ERK-2 in BAC-1.2F5 cells and that both CSF-1 and LPS activated raf-1 through similar mechanisms.

Go back
1490.0, 330.0
19.0, 19.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000018132 MO000021928

MO000021929

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m2828*m6254*0.1

nodelay

--

true

0

false

PMID: 8699127, 1698311, 1375269, 7681085 The LBP/LPS complex binds the monocyte/macrophage-specific surface receptor, CD14

Go back
628.0, 584.0
23.0, 23.0

p20

p20

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 MO000021929

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c59 : 1

m30*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 7693711 In 70Z/3 B cells stably expressing human CD14, LPS binding causedthe rapid tyrosine phosphorylation of a 38-kDa protein, p38, which is distinct from ERK-1 and ERK-2.

Go back
909.0, 333.0
21.0, 21.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000104 MO000021929

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c63 : 1
stoichiometry:c62 : 1

m92*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 7519214, 1903655 PKC activation by LPS in human monocytes has been documented and has been implicated in activation to a tumoricidal state and in production of TNF-alpha and IL-1beta.

Go back
824.0, 968.0
23.0, 23.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c64 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 8699127, 7519214, 1903655 PKC activation by LPS in human monocytes has been documented and has been implicated in activation to a tumoricidal state and in production of TNF-alpha and IL-1beta.

Go back
727.0, 971.0
25.0, 25.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 8699127, 7519214, 1903655 PKC activation by LPS in human monocytes has been documented and has been implicated in activation to a tumoricidal state and in production of TNF-alpha and IL-1beta.

Go back
1089.0, 1033.0
21.0, 21.0

p24

p24

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e41

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c111 : 1
stoichiometry:c67 : 1

m93309*m43*0.1

nodelay

--

true

0

false

PMID: 8699127, 8423328 It is interesting that under the same conditions PT treatment markedly potentiated TNF-a production in response to LPS.

Go back
1163.0, 1123.0
25.0, 25.0

p25

p25

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010389 e30

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c71 : 1

m93364*m32*0.1

nodelay

--

true

0

false

PMID: 8699127, 7519214, 1903655 PKC activation by LPS in human monocytes has been documented and has been implicated in activation to a tumoricidal state and in production of TNF-alpha and IL-1beta.

Go back
888.0, 1020.0
23.0, 23.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000021929

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c74 : 1

m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 2156930 LPS stimulated TNF-alpha expression without PKC activation.

Go back
1100.0, 716.0
23.0, 23.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000090473 MO000021929

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c78 : 1
stoichiometry:c77 : 1

m64002*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 2006186, 1516135 Low concentrations of LPS rapidly induce the major alaninerich C kinase substrates MARCKS and MacMARCKS, in macrophages.

Go back
1162.0, 850.0
19.0, 19.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 MO000021929

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c80 : 1

m34*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 2006186, 1516135 Low concentrations of LPS rapidly induce the major alanine rich Ckinase substrates MARCKS and MacMARCKS, in macrophages.

Go back
1016.0, 200.0
23.0, 23.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000104 MO000016882

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m92*m155666*0.1

nodelay

--

true

0

false

PMID: 8699127, 3465326, 3474155 LPS (and lipid A) and muramyl dipeptide can bind directly to the phosphatidyl serine site of PKC.

Go back
1546.0, 394.0
19.0, 19.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 MO000016882

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c9 : 1
stoichiometry:c8 : 1

m5*m155666*0.1

nodelay

--

true

0

false

PMID: 8699127 Apart from CD14, CD11c/CD18, a member of the leukocyte integrin family, also has the capacity to activate cells in response to LPS.

Go back
823.0, 131.0
25.0, 25.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000000104 e35

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m92*m37*0.1

nodelay

--

true

0

false

PMID: 8699127, 3465326, 3474155 LPS (and lipid A) and muramyl dipeptide can bind directly to the phosphatidyl serine site of PKC.

Go back
562.0, 234.0
19.0, 19.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e37 MO000021929

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c90 : 1
stoichiometry:c89 : 1

m39*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 8021269 LPS activated CAK in a CD14-dependent manner.

Go back
880.0, 416.0
23.0, 23.0

p32

p32

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000015 e38

MO000038411

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c93 : 1
stoichiometry:c92 : 1

m19*m40*0.1

nodelay

--

true

0

false

PMID: 8699127, 7477354 Recent evidence suggests that Raf-1 may be a direct target of CAK,providing an alternative portal of entry into the MAPK pathway.

Go back
512.0, 268.0
23.0, 23.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e37 e39

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c96 : 1
stoichiometry:c95 : 1

m39*m41*0.1

nodelay

--

true

0

false

PMID: 8699127, 8396314, 8300638 Ceramide is able to propagate signaling through the activation of a ceramide-activated protein kinase.

Go back
948.0, 1168.0
16.0, 16.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000021929 e41

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c98 : 1

m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 3095921, 2511200 PT inhibited LPS-induced IL-i production in the promonocytic cell line, U937 and the macrophage-like cell line, P388D1.

Go back
1128.0, 1184.0
23.0, 23.0

p35

p35

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e40 MO000021929 e41

MO000000214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c103 : 1
stoichiometry:c97 : 1

m42*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 3095921, 2511200 PT inhibited LPS-induced IL-i production in the promonocytic cell line, U937 and the macrophage-like cell line, P388D1.

Go back
706.0, 730.0
28.0, 28.0

p36

p36

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

MO000021929 e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c104 : 1

m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 8423328 PT also inhibited nitric oxide production from LPS-stimulated mouse peritoneal macrophages.

Go back
260.0, 948.0
23.0, 23.0

p37

p37

cso30:i:ME_ADPRibosylation

cso30:i:CC_Cytosol

--

e43 e41

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c109 : 1
stoichiometry:c108 : 1

m45*m43*0.1

nodelay

--

true

0

false

PMID: 8699127, 8423328 PT also inhibited nitric oxide production from LPS-stimulated mouse peritoneal macrophages and this correlated with ADP-ribosylation of a 41-kDa membrane protein by PT.

Go back
666.0, 78.0
27.0, 27.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e45 MO000016882

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c114 : 1
stoichiometry:c113 : 1

m47*m155666*0.1

nodelay

--

true

0

false

PMID: 8699127, 8510674 An interaction between LPS and one such protein, MAP-2 was demonstrated using overlay assays.

Go back
945.0, 641.0
21.0, 21.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e19 e47

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c117 : 1
stoichiometry:c116 : 1

m20*m49*0.1

nodelay

--

true

0

false

PMID: 8699127, 7901279 Both LPS and taxol were able to activate MAPK, which can phosphorylate MAP-2.

Go back
1218.0, 249.0
25.0, 25.0

p4

p4

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

MO000038021 MO000021929

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c12 : 1
stoichiometry:c11 : 1

m16258*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 8521300 enhancement of autophosphorylation of both p53 and p56 lyn upon LPS addition to primary murine macrophages.

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946.0, 670.0
19.0, 19.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e19 MO000021929

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c120 : 1
stoichiometry:c119 : 1

m20*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 7901279 Both LPS and taxol were able to activate MAPK, which can phosphorylate MAP-2.

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758.0, 206.0
19.0, 19.0

p41

p41

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e45 e20

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c123 : 1
stoichiometry:c122 : 1

m47*m21*0.1

nodelay

--

true

0

false

PMID: 8699127, 7901279 Both LPS and taxol were able to activate MAPK, which can phosphorylate MAP-2.

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392.0, 996.0
23.0, 23.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017284 MO000021929

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c126 : 1
stoichiometry:c125 : 1

m2137*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127 Two Ets family members, Ets-2 and Elk-1 were demonstrated to be LPS inducible in macrophages.

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903.0, 831.0
25.0, 25.0

p43

p43

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000038 MO000021929 e63

MO000038364

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c128 : 1

m65*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 7989771 Treatment with the tyrosine kinase inhibitor, genestein, blocked LPS-induced Elk-1 phosphorylation in BAC-1.2F5 macrophages.

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663.0, 1171.0
26.0, 26.0

p44

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000037579

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m15836*0.1

nodelay

--

true

0

false

PMID: 8699127, 8355682, 8095266, 8264604, 7964503, 8195721, 8302571, 7799967 The expression of genes encoding pro-IL-1beta, macrophage inflammatory protein (MIP)-la, CD1lb Fc¡ÇyRlb and the CSF-l receptor all appear to be regulated by this protein.

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460.0, 1212.0
23.0, 23.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000037579

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c133 : 1

m15836*0.1

nodelay

--

true

0

false

PMID: 8699127, 8355682, 8095266, 8264604, 7964503, 8195721, 8302571, 7799967 The expression of genes encoding pro-IL-1beta, macrophage inflammatory protein (MIP)-la, CD1lb Fc¡ÇyRlb and the CSF-l receptor all appear to be regulated by this protein.

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772.0, 1316.0
23.0, 23.0

p46

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000037579

G010492

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c135 : 1

m15836*0.1

nodelay

--

true

0

false

PMID: 8699127, 8355682, 8095266, 8264604, 7964503, 8195721, 8302571, 7799967 The expression of genes encoding pro-IL-1beta, macrophage inflammatory protein (MIP)-la, CD1lb Fc¡ÇyRlb and the CSF-l receptor all appear to be regulated by this protein.

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525.0, 1209.0
21.0, 21.0

p47

p47

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000037579

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c137 : 1

m15836*0.1

nodelay

--

true

0

false

PMID: 8699127, 8355682, 8095266, 8264604, 7964503, 8195721, 8302571, 7799967 The expression of genes encoding pro-IL-1beta, macrophage inflammatory protein (MIP)-la, CD1lb Fc¡ÇyRlb and the CSF-l receptor all appear to be regulated by this protein.

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672.0, 1068.0
23.0, 23.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000037579 e23

G010435

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c68 : 1
stoichiometry:c139 : 1

m15836*0.1

nodelay

--

true

0

false

PMID: 8699127, 8355682, 8095266, 8264604, 7964503, 8195721, 8302571, 7799967 The expression of genes encoding pro-IL-1beta, macrophage inflammatory protein (MIP)-la, CD1lb Fc¡ÇyRlb and the CSF-l receptor all appear to be regulated by this protein. PMID: 8699127, 3035291, 2548952, 1338337 LPS down regulates CSF-1 receptor expression and is thus a powerful inhibitor of CSF-1 induced growth.

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643.0, 1279.0
25.0, 25.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e66 MO000037579

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m69*m15836*0.1

nodelay

--

true

0

false

PMID: 8699127, 8434021 This model is supported by the observation that PU.l can interactwith the general transcription factor TFIID.

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1194.0, 394.0
27.0, 27.0

p5

p5

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

MO000038022 MO000021929

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c14 : 1

m16259*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 8521300 enhancement of autophosphorylation of both p53 and p56 lyn upon LPS addition to primary murine macrophages.

Go back
783.0, 1147.0
25.0, 25.0

p50

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e68

G012405

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c144 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 8699127, 8392062 An increase in JunB mRNA and protein was observed in response to LPS. PMID: 8699127, 8392062 Activation of JunB in response to LPS was independent of PMA-sensitive PKC but required PKA as determined by experiments with kinase inhibitors and agents that elevate intracellular cAMP levels.

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1095.0, 1275.0
17.0, 17.0

p51

p51

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G012405 e68

MO000007828

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c152 : 1
stoichiometry:c147 : 1

m95154*m71*0.1

nodelay

--

true

0

false

PMID: 8699127, 8392062 An increase in JunB mRNA and protein was observed in response to LPS. PMID: 8699127, 8392062 Activation of JunB in response to LPS was independent of PMA-sensitive PKC but required PKA as determined by experiments with kinase inhibitors and agents that elevate intracellular cAMP levels.

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860.0, 1172.0
23.0, 23.0

p52

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000021929

G010232

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c149 : 1

m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 8392062, 2477086 LPS increased c-jun mRNA in J774cells and in human monocytes.

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393.0, 573.0
21.0, 21.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e69 MO000021929

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c153 : 1
stoichiometry:c146 : 1

m72*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 8392062 Activation of JunB in response to LPS was independent of PMA-sensitive PKC but required PKA as determined by experiments with kinase inhibitors and agents that elevate intracellular cAMP levels.

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548.0, 1008.0
23.0, 23.0

p54

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000021929

G010214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 8217790, 3110291 Expression ofthe other AP-1 subunit, c-fos, was also induced by LPS in murine macrophages.

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570.0, 1082.0
27.0, 27.0

p55

p55

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000021929 e70 e71

G010625

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c162 : 1
stoichiometry:c164 : 1
stoichiometry:c159 : 1

m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 1401930 LPS treatment of murine peritoneal macrophages resulted in rapid induction of Egr-1 mRNA and protein.The effect of LPS on Egr-1 mRNA was inhibited by chronic PMA treatment and by treatment with the PKC inhibitor, H-7 indicating a probable involvement of PMA sensitive PKC in this LPS response.

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373.0, 1253.0
30.0, 30.0

p56

p56

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000021929 G010625 e70 e71

MO000017190

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c163 : 1
stoichiometry:c156 : 1

m6255*m93569*0.1

nodelay

--

true

0

false

PMID: 8699127, 1401930 LPS treatment of murine peritoneal macrophages resulted in rapid induction of Egr-1 mRNA and protein.The effect of LPS on Egr-1 mRNA was inhibited by chronic PMA treatment and by treatment with the PKC inhibitor, H-7 indicating a probable involvement of PMA sensitive PKC in this LPS response.

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409.0, 365.0
21.0, 21.0

p57

p57

cso30:i:ME_Processing

cso30:i:CC_Cytosol

--

MO000000199 MO000021929

MO000100032

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c167 : 1
stoichiometry:c166 : 1

m171*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 8349609 LPS also appears to increase proteolytic processing of p105 to produce NF-KB1

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564.0, 500.0
23.0, 23.0

p58

p58

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e72 MO000021929

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c173 : 1
stoichiometry:c172 : 1

m75*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 8505309, 7565683 Treatment of human monocytic THP-1 cells with LPS caused phosphorylation of IKBalpha and more recent studies have demonstrated that phosphorylation of IKBalpha on serines 32 and 36 by LPS is necessary for its subsequent degradation.

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505.0, 437.0
21.0, 21.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000100032 e73

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c170 : 1

m73069*m76*0.1

nodelay

--

true

0

false

PMID: 8699127 Induction of nuclear NF-kappaB by growth factors, mitogens, cellular activators, and activators of second messengers appears to be mediated by an inhibitor of NF-KB, IKappaB, which binds NF-KB thus forming an inactive cytoplasmic complex.

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1230.0, 485.0
17.0, 17.0

p6

p6

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e13 MO000021929

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m13*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 7691802 Other tyrosine kinases activated by LPS may include p58/64?yn and p59c-fgr.

Go back
528.0, 628.0
23.0, 23.0

p60

p60

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e75

e74 e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c175 : 1
stoichiometry:c176 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 8699127, 8505309, 7565683 Treatment of human monocytic THP-1 cells with LPS caused phosphorylation of IKBalpha and more recent studies have demonstrated that phosphorylation of IKBalpha on serines 32 and 36 by LPS is necessary for its subsequent degradation.

Go back
1020.0, 1084.0
23.0, 23.0

p61

p61

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000021929

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c177 : 1

m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 1380488 NF-IL6 mRNA was increased in tissue samples in response to LPS.

Go back
1324.0, 844.0
23.0, 23.0

p62

p62

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e78 e68

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c181 : 1
stoichiometry:c180 : 1

m81*m71*0.1

nodelay

--

true

0

false

PMID: 8699127, 8336793, 8200992 PKA and PKC phosphorylated serine 105 in the NF-IL6 activation domain.

Go back
1296.0, 872.0
23.0, 23.0

p63

p63

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e78 e30

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c184 : 1
stoichiometry:c183 : 1

m81*m32*0.1

nodelay

--

true

0

false

PMID: 8699127, 8336793, 8200992 PKA and PKC phosphorylated serine 105 in the NF-IL6 activation domain.

Go back
350.0, 842.0
27.0, 27.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e76 e78

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m79*m81*0.1

nodelay

--

true

0

false

PMID: 8699127, 1518839, 8234276, 7935377, 7706280 Interactions between NF-1L6 and other proteins including NF-KB and AP-1 have been documented.

Go back
1245.0, 957.0
21.0, 21.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000276 e78

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1
stoichiometry:c190 : 1

m219*m81*0.1

nodelay

--

true

0

false

PMID: 8699127, 1518839, 8234276, 7935377, 7706280 Interactions between NF-1L6 and other proteins including NF-KB and AP-1 have been documented.

Go back
685.0, 1688.0
23.0, 23.0

p66

p66

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e83 e82

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c192 : 1
stoichiometry:c193 : 1

m86*m85*0.1

nodelay

--

true

0

false

PMID: 8699127, 8197455, 7566171 The binding of IFN-gamma to its receptor activates members of the JAK family of tyrosine kinases, JAK1 and JAK2, which are associated with the IFN-gamma receptor

Go back
789.0, 1497.0
21.0, 21.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e84 MO000000145

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1
stoichiometry:c196 : 1

m87*m129*0.1

nodelay

--

true

0

false

PMID: 8699127, 8197455, 7566171 The binding of IFN-gamma to its receptor activates members of the JAK family of tyrosine kinases, JAK1 and JAK2, which are associated with the IFN-gamma receptor

Go back
868.0, 1488.0
23.0, 23.0

p68

p68

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e84 MO000000146

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c198 : 1
stoichiometry:c199 : 1

m87*m130*0.1

nodelay

--

true

0

false

PMID: 8699127, 8197455, 7566171 The binding of IFN-gamma to its receptor activates members of the JAK family of tyrosine kinases, JAK1 and JAK2, which are associated with the IFN-gamma receptor

Go back
1107.0, 1483.0
25.0, 25.0

p69

p69

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 e86

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c202 : 1
stoichiometry:c201 : 1

m1357*m89*0.1

nodelay

--

true

0

false

PMID: 8699127, 7690989, 7510216 Activated JAKs in turn phosphorylate STAT1, a member of the STAT family, on tyrosine 701.

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1262.0, 536.5
18.5, 18.5

p7

p7

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e15 MO000021929

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c21 : 1
stoichiometry:c20 : 1

m15*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 7691802 Other tyrosine kinases activated by LPS may include p58/64?yn and p59c-fgr.

Go back
1140.0, 1440.0
23.0, 23.0

p70

p70

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 e85

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c205 : 1
stoichiometry:c204 : 1

m1357*m88*0.1

nodelay

--

true

0

false

PMID: 8699127, 7690989, 7510216 Activated JAKs in turn phosphorylate STAT1, a member of the STAT family, on tyrosine 701.

Go back
1279.0, 1427.0
25.0, 25.0

p71

p71

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000019704

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c207 : 1

m4238*0.1

nodelay

--

true

0

false

PMID: 8699127, 8197455 This phosphorylation event allows STAT proteins to dimerize and translocate to the nucleus where they can activate transcription through recognition of promoter elements designated IFN-gamma activation sites.

Go back
1002.0, 1362.0
27.0, 27.0

p72

p72

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e87

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c208 : 1
stoichiometry:c209 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 8699127, 8197455 This phosphorylation event allows STAT proteins to dimerize and translocate to the nucleus where they can activate transcription through recognition of promoter elements designated IFN-gamma activation sites.

Go back
564.0, 1488.0
24.0, 24.0

p73

p73

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000007685 e84

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c212 : 1
stoichiometry:c211 : 1

m970*m87*0.1

nodelay

--

true

0

false

PMID: 8699127, 1372386 Several other nuclear factors are induced by IFN-gamma including IRF-1/ISGF2.

Go back
392.0, 1488.0
23.0, 23.0

p74

p74

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e90 e84

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c215 : 1
stoichiometry:c214 : 1

m94*m87*0.1

nodelay

--

true

0

false

PMID: 8699127, 1315834 Several other nuclear factors are induced by IFN-gamma including IRF-1/ISGF2 and ISGF3.

Go back
694.0, 1234.0
27.0, 27.0

p75

p75

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e84 MO000021929

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c218 : 1
stoichiometry:c216 : 1

m87*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 7692452, 7684434, 7541763 Genes such as iNOS, which are synergistically activated by LPS and IFN-gamma, have been analyzed at the transcriptional level.

Go back
861.0, 969.0
21.0, 21.0

p76

p76

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e92

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c219 : 1

m96*0.1

nodelay

--

true

0

false

PMID: 8699127 DNA added to RAW264 cells acts even when added externally, and can induce a range of LPS-like responses including induction of TNF-alpha.

Go back
1109.0, 1077.0
21.0, 21.0

p77

p77

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

G010329 e92

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c223 : 1
stoichiometry:c222 : 1

m93309*m96*0.1

nodelay

--

true

0

false

--

Go back
792.0, 960.0
23.0, 23.0

p22

p78

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e41

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c225 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 8699127, 8423328 It is interesting that under the same conditions PT treatment markedly potentiated TNF-a production in response to LPS.

Go back
1129.0, 1005.0
21.0, 21.0

p24

p79

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e30 G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c227 : 1
stoichiometry:c226 : 1

m32*m93309*0.1

nodelay

--

true

0

false

PMID: 8699127, 7519214, 1903655 PKC activation by LPS in human monocytes has been documented and has been implicated in activation to a tumoricidal state and in production of TNF-alpha and IL-1beta.

Go back
1241.0, 696.0
23.0, 23.0

p8

p8

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e17 MO000021929

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c24 : 1
stoichiometry:c23 : 1

m17*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127, 7691802 Other tyrosine kinases activated by LPS may include p58/64?yn and p59c-fgr.

Go back
1008.0, 472.0
23.0, 23.0

p9

p9

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000015 MO000021929

MO000038411

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c27 : 1
stoichiometry:c26 : 1

m19*m6255*0.1

nodelay

--

true

0

false

PMID: 8699127 LPS addition to BAC-1.2F5 macrophages led to rapid phosphorylation and activation of Raf-1.

Go back
1515.0, 232.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1175.0, 238.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1146.2817386022941, 317.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
963.6544374799411, 317.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
506.0, 825.0

c102

c102

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
513.0, 825.0

c103

c103

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
639.9536563805268, 734.8598547438407

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
740.7049672354027, 310.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
514.0, 749.0456619029133

c106

c106

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
216.0, 910.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
229.97927454946927, 970.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
289.49992787104566, 825.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1168.7365962981012, 266.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
826.0, 446.0

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
514.0, 820.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
680.0, 113.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
563.0858607382584, 104.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.9670795883692, 93.7250122982338

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
881.0, 620.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
966.0, 618.9261191291088

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.0, 471.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
881.0, 627.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
965.0, 624.1171199266936

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1250.8529231173486, 265.5269572728178

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
971.100505280466, 314.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
701.0, 216.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.0, 225.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
781.2806398907792, 231.00956257508915

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
410.69069117598525, 968.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
388.69082189313593, 1019.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
421.52661190214565, 311.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
883.0, 811.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
905.6168845110653, 856.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
933.3414675295114, 317.0

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1209.228478191191, 359.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
729.0, 844.0

c130

c130

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
596.0, 1202.851414607361

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
688.0, 1144.8362976331207

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
472.0, 1169.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
489.15143182179867, 1238.1146736495855

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
795.0, 1328.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0, 1321.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
529.5699763999032, 1132.9796695986458

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.729912613766, 1237.0772700876587

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
661.6568542494924, 1058.6568542494924

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1168.7748008455096, 397.884800204972

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.0, 1098.4181672241473

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
659.3902826712724, 1262.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 1301.0364508500504

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
668.0, 1292.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.0, 1172.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.0, 515.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.0, 594.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1112.0, 1284.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.0, 1246.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
872.0, 1195.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1227.9793310573443, 308.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
883.1336234862963, 317.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
414.0, 669.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
414.0, 665.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
421.69010039497766, 302.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
577.0829894255471, 314.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
535.8161052203985, 1031.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
303.0, 1268.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.79058381203066, 316.0

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
602.7397910747118, 316.0

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
584.0, 1109.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1215.0, 457.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
410.2344710503944, 1185.0

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
375.0, 1286.9587494835228

c161

c161

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
385.0, 1112.1907870758303

c162

c162

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
402.4795947002425, 1286.1387274686613

c163

c163

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
497.0, 1112.8282151051417

c164

c164

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
420.0, 325.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
423.0, 386.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.9742299563793, 298.0

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
460.0, 449.8834522085988

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
481.0, 464.6064078549882

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1191.8174109113825, 496.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.0, 448.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
576.0, 469.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
576.0, 523.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.7425800543061, 301.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
556.4057970281387, 616.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.6845141153165, 643.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
540.0, 651.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1032.0, 1107.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1041.3990991925152, 317.0

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1336.0, 707.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1252.1853964601914, 317.0

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1336.0, 867.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
414.0, 658.0

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1311.1515187657128, 707.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1314.0, 895.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
834.0, 445.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
383.46988867442553, 743.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
384.88886654949624, 696.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.2494651199621, 863.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1164.0, 968.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1261.214009474424, 707.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1204.0, 546.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1266.0, 978.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
677.0, 1634.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
715.8968438219807, 1703.2805692684292

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
706.0, 1618.3192923467116

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
787.0, 1525.7611400011626

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
751.0, 1485.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
809.0, 1518.0

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.0, 1516.449845567197

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.4867851613561, 1457.0

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
890.0, 1511.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1610.2447724594695, 190.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1221.0285524572716, 554.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1043.0, 1496.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1132.0, 1496.0

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
994.0, 1509.6225353953369

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1043.0, 1458.5766215968035

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1163.0, 1458.0

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
902.0, 1462.8121690507721

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1259.0, 1457.897233121606

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1292.0, 1403.0

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1037.0, 1376.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
968.1709862283207, 1336.0910636383644

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1279.8308170454445, 317.0

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
576.0, 1447.0

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 1500.0

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
595.2899677344119, 1508.2949006709207

c212

c212

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
343.0, 1497.0

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
415.0, 1500.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
422.7740296315538, 1504.887978624806

c215

c215

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
713.0, 1212.4799802105422

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
712.6389052329815, 1268.8303250020228

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
722.7424761387522, 317.0

c218

c218

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
862.894358184543, 990.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1202.0, 660.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
889.6088117468317, 775.0

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
878.0, 1088.0

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1130.0, 1052.6707771379567

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1136.2769803071521, 775.0

c223

c223

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
514.0, 823.0

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
809.0, 983.0

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1150.0, 1019.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
878.0, 1020.9765982641386

c227

c227

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1247.509867769654, 719.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1260.806821240265, 317.0

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
990.0, 439.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
991.3599068047633, 495.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1038.1953842870148, 306.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
881.0, 612.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.0, 612.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1576.8311367793272, 243.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
957.383083722649, 569.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
923.0, 732.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
987.0, 732.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
993.0779162746717, 628.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
992.6286410367686, 317.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
681.0, 310.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
716.0, 351.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
734.9838506849135, 297.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1426.0, 246.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
97.0, 588.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
144.53696065787142, 540.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.0, 628.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
348.0, 374.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 442.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
240.0, 449.0330434938024

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
362.0, 374.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
360.3400013724057, 427.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
414.94358858685416, 298.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
336.0, 684.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1515.70398467766, 306.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
333.5096012338027, 749.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 684.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.0414336125515, 755.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
240.0, 671.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
390.34328831021196, 305.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
916.6367019809553, 434.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
910.0, 486.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
240.0, 481.10493924633687

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
640.0, 535.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
640.0, 607.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1436.2250720367338, 309.43487031254557

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
658.449942237646, 304.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
920.0, 230.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.2469504755443, 353.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
937.9614957757415, 298.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
838.0, 991.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
817.0, 446.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
878.0, 1047.4540438496788

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1110.0, 1044.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.1911688610903, 441.0

c68

c68

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
743.0869685335508, 446.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1428.0, 405.40625482143935

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
740.0, 996.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1188.0, 1136.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
763.0, 1117.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
825.0, 446.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
877.6039472493969, 1043.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.5429580268598, 317.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1090.0, 665.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1101.8529642184483, 739.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1124.5287226345451, 317.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1172.0, 806.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1430.1127881487162, 412.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1172.0, 869.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1179.0877346729817, 317.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
938.0, 212.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1046.9929564480665, 185.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1028.0, 223.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
854.2018798841383, 159.0533836092979

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
843.9711254108329, 61.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
836.0, 156.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
465.0, 244.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
571.1311299219144, 253.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1566.3016820929984, 198.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.9846510508471, 245.49532574757117

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
910.9816776169414, 423.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
899.0, 439.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.0, 335.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
465.0, 252.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 291.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
386.0, 277.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1151.0, 1196.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
956.0, 1184.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
986.0, 1199.547664196261

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back