_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e4
_enti_e2
_enti_e3
_enti_e55
_enti_e53
_enti_e59
_enti_e50
_enti_e54
_enti_e56
_enti_e51
_enti_e52
_enti_e57
_enti_e61
_enti_e58
_enti_e60
_enti_e62
g1_fact_g1
g1_fact_g14
g2_fact_g12
g2_fact_g13
p1_propro_p1
PMID: 9792624,9238507
It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha
PMID: 9792624,9528783
In agreement with this idea, it has been
recently demonstrated that Stat3 is involved in the IL-6-induced
up-regulation of both C/EBPd and C/EBPb gene promoters
c1 cso30:c:InputAssociation connector
c49 cso30:c:InputAssociation connector
c2 cso30:c:OutputProcess connector
p1_propro_p2
PMID: 9792624,9238507
It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha
PMID: 9792624,9528783
In agreement with this idea, it has been
recently demonstrated that Stat3 is involved in the IL-6-induced
up-regulation of both C/EBPd and C/EBPb gene promoters
c3 cso30:c:InputAssociation connector
c50 cso30:c:InputAssociation connector
c4 cso30:c:OutputProcess connector
p1_propro_p3
PMID: 9792624,9238507
It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha
c5 cso30:c:InputAssociation connector
c6 cso30:c:OutputProcess connector
p1_propro_p4
PMID: 9792624,9238507
It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha
c7 cso30:c:InputAssociation connector
c8 cso30:c:OutputProcess connector
p1_propro_p5
PMID: 9792624,9238507
It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha
c9 cso30:c:InputAssociation connector
c10 cso30:c:OutputProcess connector
p1_propro_p6
PMID: 9792624,9238507
It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha
c11 cso30:c:InputAssociation connector
c12 cso30:c:OutputProcess connector
p1_propro_p7
PMID: 9792624,9238507
It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha
c13 cso30:c:InputAssociation connector
c14 cso30:c:OutputProcess connector
p1_propro_p8
PMID: 9792624,9238507
It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha
c15 cso30:c:InputAssociation connector
c16 cso30:c:OutputProcess connector
p1_propro_p9
PMID: 9792624,9238507
It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha
c17 cso30:c:InputAssociation connector
c18 cso30:c:OutputProcess connector
p1_propro_p10
PMID: 9792624,9238507
It has been subsequently determined by many independent studies that both C/EBPbeta and -delta are strongly up-regulated at the transcriptional level by inflammatory stimuli such as turpentine oil and bacterial lipopolysaccharide and by recombinant cytokines such as IL-6, IL-1, and TNF-alpha
c19 cso30:c:InputAssociation connector
c20 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 9792624,1371993
Conversely, C/EBPalpha is slightly down-regulated under the same conditions
c21 cso30:c:InputInhibitor connector
c22 cso30:c:OutputProcess connector
p11_propro_p12
PMID: 9792624,1371993
Conversely, C/EBPalpha is slightly down-regulated under the same conditions
c23 cso30:c:InputInhibitor connector
c24 cso30:c:OutputProcess connector
p11_propro_p13
PMID: 9792624,1371993
Conversely, C/EBPalpha is slightly down-regulated under the same conditions
c25 cso30:c:InputInhibitor connector
c26 cso30:c:OutputProcess connector
p11_propro_p14
PMID: 9792624,1371993
Conversely, C/EBPalpha is slightly down-regulated under the same conditions
c27 cso30:c:InputInhibitor connector
c28 cso30:c:OutputProcess connector
p11_propro_p15
PMID: 9792624,1371993
Conversely, C/EBPalpha is slightly down-regulated under the same conditions
c29 cso30:c:InputInhibitor connector
c30 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 9792624,1314426,8336793
Phosphorylation of serine 276 has been shown to take place in a
pituitary cell line in response to intracellular Ca21 increase via a
calcium/calmodulin-dependent kinase; activation of the protein
kinase C pathway causes phosphorylation of Ser-105 in HepG2
cells
c31 cso30:c:InputAssociation connector
c32 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 9792624,1314426,8336793
Phosphorylation of serine 276 has been shown to take place in a
pituitary cell line in response to intracellular Ca21 increase via a
calcium/calmodulin-dependent kinase; activation of the protein
kinase C pathway causes phosphorylation of Ser-105 in HepG2
cells
c33 cso30:c:InputAssociation connector
c34 cso30:c:InputProcess connector
c35 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 9792624,1314426,8336793
Phosphorylation of serine 276 has been shown to take place in a
pituitary cell line in response to intracellular Ca21 increase via a
calcium/calmodulin-dependent kinase; activation of the protein
kinase C pathway causes phosphorylation of Ser-105 in HepG2
cells
PMID: 9792624,1314426,8336793
Phosphorylation of serine 276 has been shown to take place in a
pituitary cell line in response to intracellular Ca21 increase via a
calcium/calmodulin-dependent kinase; activation of the protein
kinase C pathway causes phosphorylation of Ser-105 in HepG2
cells
c36 cso30:c:InputProcess connector
c37 cso30:c:OutputProcess connector
p17_propro_p19
PMID: 9792624,1314426,8336793
Phosphorylation of serine 276 has been shown to take place in a
pituitary cell line in response to intracellular Ca21 increase via a
calcium/calmodulin-dependent kinase; activation of the protein
kinase C pathway causes phosphorylation of Ser-105 in HepG2
cells
c38 cso30:c:InputAssociation connector
c39 cso30:c:InputProcess connector
c40 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 9792624,8384717
Finally, activation of mitogen-activated protein kinase
following induction of the Ras pathway leads to phosphorylation of
Thr-235
PMID: 9792624
Figure1
PMID: 9792624
Both
TNF-a and IL-1b are known to trigger nuclear
translocation of NF-kB and activation
of the Ras pathway, as well as transcriptional
induction of C/EBPb and C/EBPd
(whose mechanism is still unknown),
whereas IL-6 mediates activation of Stat3
and of the Ras pathway, which ultimately
leads to phosphorylation and activation of
C/EBPb.
c41 cso30:c:InputProcess connector
c87 cso30:c:InputAssociation connector
c42 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 9792624,8384717
Finally, activation of mitogen-activated protein kinase
following induction of the Ras pathway leads to phosphorylation of
Thr-235
PMID: 9792624
Figure1
c44 cso30:c:InputAssociation connector
c45 cso30:c:InputProcess connector
c97 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 9792624,8321203,151883
Among those, the interactions
with members of the NF-kB family of transcription factors (47, 48)
are particularly intriguing because they link the pathways of two
major mediators of inflammation, IL-1 and IL-6.
c46 cso30:c:InputProcess connector
c47 cso30:c:InputProcess connector
c48 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 9792624
Both
TNF-a and IL-1b are known to trigger nuclear
translocation of NF-kB and activation
of the Ras pathway, as well as transcriptional
induction of C/EBPb and C/EBPd
(whose mechanism is still unknown),
whereas IL-6 mediates activation of Stat3
and of the Ras pathway, which ultimately
leads to phosphorylation and activation of
C/EBPb.
PMID: 9792624
Figure1
c51 cso30:c:InputProcess connector
c52 cso30:c:InputProcess connector
c53 cso30:c:OutputProcess connector
p23_propro_p24
PMID: 9792624
Both
TNF-a and IL-1b are known to trigger nuclear
translocation of NF-kB and activation
of the Ras pathway, as well as transcriptional
induction of C/EBPb and C/EBPd
(whose mechanism is still unknown),
whereas IL-6 mediates activation of Stat3
and of the Ras pathway, which ultimately
leads to phosphorylation and activation of
C/EBPb.
PMID: 9792624
Figure1
c54 cso30:c:InputProcess connector
c55 cso30:c:InputProcess connector
c56 cso30:c:InputProcess connector
c57 cso30:c:OutputProcess connector
p23_propro_p25
PMID: 9792624
Both
TNF-a and IL-1b are known to trigger nuclear
translocation of NF-kB and activation
of the Ras pathway, as well as transcriptional
induction of C/EBPb and C/EBPd
(whose mechanism is still unknown),
whereas IL-6 mediates activation of Stat3
and of the Ras pathway, which ultimately
leads to phosphorylation and activation of
C/EBPb.
PMID: 9792624
Figure1
c58 cso30:c:InputProcess connector
c59 cso30:c:InputProcess connector
c60 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 9792624
Figure1
PMID: 9792624
This suggests a sequential model in which the induction of inflammatory
cytokines such as IL-1 and IL-6 in response to inflammatory
stimuli would first trigger the activation of pre-existing, inactive
forms of Stat3 and NF-kB
c61 cso30:c:InputAssociation connector
c62 cso30:c:InputProcess connector
c63 cso30:c:OutputProcess connector
p26_propro_p27
PMID: 9792624
Figure1
PMID: 9792624
This suggests a sequential model in which the induction of inflammatory
cytokines such as IL-1 and IL-6 in response to inflammatory
stimuli would first trigger the activation of pre-existing, inactive
forms of Stat3 and NF-kB
c64 cso30:c:InputAssociation connector
c65 cso30:c:InputProcess connector
c66 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 9792624
Both
TNF-a and IL-1b are known to trigger nuclear
translocation of NF-kB and activation
of the Ras pathway, as well as transcriptional
induction of C/EBPb and C/EBPd
(whose mechanism is still unknown),
whereas IL-6 mediates activation of Stat3
and of the Ras pathway, which ultimately
leads to phosphorylation and activation of
C/EBPb.
PMID: 9792624
Figure1
c67 cso30:c:InputProcess connector
c68 cso30:c:OutputProcess connector
p29_propro_p29
c69 cso30:c:InputProcess connector
c75 cso30:c:InputAssociation connector
c76 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 9792624
Figure1
c43 cso30:c:InputAssociation connector
c70 cso30:c:InputProcess connector
c71 cso30:c:OutputProcess connector
p30_propro_p31
PMID: 9792624
Figure1
c72 cso30:c:InputAssociation connector
c73 cso30:c:InputProcess connector
c74 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 9792624
Figure1
PMID: 9792624
Both
TNF-a and IL-1b are known to trigger nuclear
translocation of NF-kB and activation
of the Ras pathway, as well as transcriptional
induction of C/EBPb and C/EBPd
(whose mechanism is still unknown),
whereas IL-6 mediates activation of Stat3
and of the Ras pathway, which ultimately
leads to phosphorylation and activation of
C/EBPb.
c77 cso30:c:InputAssociation connector
c78 cso30:c:OutputProcess connector
p32_propro_p33
PMID: 9792624
Figure1
PMID: 9792624
Both
TNF-a and IL-1b are known to trigger nuclear
translocation of NF-kB and activation
of the Ras pathway, as well as transcriptional
induction of C/EBPb and C/EBPd
(whose mechanism is still unknown),
whereas IL-6 mediates activation of Stat3
and of the Ras pathway, which ultimately
leads to phosphorylation and activation of
C/EBPb.
c79 cso30:c:InputAssociation connector
c80 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 9792624
Figure1
c81 cso30:c:InputProcess connector
c82 cso30:c:OutputProcess connector
p32_propro_p35
PMID: 9792624
Figure1
PMID: 9792624
Both
TNF-a and IL-1b are known to trigger nuclear
translocation of NF-kB and activation
of the Ras pathway, as well as transcriptional
induction of C/EBPb and C/EBPd
(whose mechanism is still unknown),
whereas IL-6 mediates activation of Stat3
and of the Ras pathway, which ultimately
leads to phosphorylation and activation of
C/EBPb.
c83 cso30:c:InputAssociation connector
c84 cso30:c:OutputProcess connector
p32_propro_p36
PMID: 9792624
Figure1
PMID: 9792624
Both
TNF-a and IL-1b are known to trigger nuclear
translocation of NF-kB and activation
of the Ras pathway, as well as transcriptional
induction of C/EBPb and C/EBPd
(whose mechanism is still unknown),
whereas IL-6 mediates activation of Stat3
and of the Ras pathway, which ultimately
leads to phosphorylation and activation of
C/EBPb.
c85 cso30:c:InputAssociation connector
c86 cso30:c:OutputProcess connector
p20_propro_p37
PMID: 9792624,8384717
Finally, activation of mitogen-activated protein kinase
following induction of the Ras pathway leads to phosphorylation of
Thr-235
PMID: 9792624
Figure1
PMID: 9792624
Both
TNF-a and IL-1b are known to trigger nuclear
translocation of NF-kB and activation
of the Ras pathway, as well as transcriptional
induction of C/EBPb and C/EBPd
(whose mechanism is still unknown),
whereas IL-6 mediates activation of Stat3
and of the Ras pathway, which ultimately
leads to phosphorylation and activation of
C/EBPb.
c88 cso30:c:InputAssociation connector
c89 cso30:c:InputProcess connector
c90 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 9792624
Both
TNF-a and IL-1b are known to trigger nuclear
translocation of NF-kB and activation
of the Ras pathway, as well as transcriptional
induction of C/EBPb and C/EBPd
(whose mechanism is still unknown),
whereas IL-6 mediates activation of Stat3
and of the Ras pathway, which ultimately
leads to phosphorylation and activation of
C/EBPb.
PMID: 9792624
Figure1
c91 cso30:c:InputAssociation connector
c92 cso30:c:InputProcess connector
c93 cso30:c:OutputProcess connector
p38_propro_p39
PMID: 9792624
Both
TNF-a and IL-1b are known to trigger nuclear
translocation of NF-kB and activation
of the Ras pathway, as well as transcriptional
induction of C/EBPb and C/EBPd
(whose mechanism is still unknown),
whereas IL-6 mediates activation of Stat3
and of the Ras pathway, which ultimately
leads to phosphorylation and activation of
C/EBPb.
PMID: 9792624
Figure1
c94 cso30:c:InputAssociation connector
c95 cso30:c:InputProcess connector
c96 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 9792624,8557032
Moreover, as already mentioned, C/EBP family members can
specifically transactivate the promoters of several myeloid-specific
genes, and the chicken homologue of C/EBPb, NF-M, is a myeloidspecific
factor mediating eosinophils differentiation
c99 cso30:c:InputAssociation connector
c98 cso30:c:OutputProcess connector
p40_propro_p41
PMID: 9792624,8557032
Moreover, as already mentioned, C/EBP family members can
specifically transactivate the promoters of several myeloid-specific
genes, and the chicken homologue of C/EBPb, NF-M, is a myeloidspecific
factor mediating eosinophils differentiation
c100 cso30:c:InputAssociation connector
c101 cso30:c:OutputProcess connector
C/EBPalpha_enti_G010325
C/EBPalpha
C/EBPbeta_enti_G010787
C/EBPbeta
IL-6_enti_MO000007384
IL-6
IL-1_enti_MO000000214
IL-1
TNF-alpha_enti_MO000000289
TNF-alpha
LPS_enti_MO000016882
LPS
C/EBPdelta_enti_e5
C/EBPdelta
Turpentine oil_enti_e6
Turpentine oil
Calcium/calmodulin dependent kinase_enti_e11
Calcium/calmodulin dependent kinase
calcium_enti_e12
calcium
C/EBPbeta_enti_MO000016580
C/EBPbeta
C/EBPbeta{p}_enti_e13
C/EBPbeta{p}
PKC_enti_MO000000104
PKC
PKC{active}_enti_e14
PKC{active}
Ras_enti_MO000016736
Ras
Ras{active}_enti_e15
Ras{active}
NF-KappaB family proteins_enti_e16
NF-KappaB family proteins
C/EBPbeta:NF-KappaB family proteins_enti_e17
C/EBPbeta:NF-KappaB family proteins
STAT3{active}_enti_MO000013122
STAT3{active}
IL-1beta_enti_MO000016597
IL-1beta
IL-1R_enti_e18
IL-1R
IL-1beta:Il-1R_enti_e19
IL-1beta:Il-1R
gp130_enti_MO000016943
gp130
IL-6R_enti_MO000018458
IL-6R
IL-6:gp130:IL-6R_enti_e20
IL-6:gp130:IL-6R
TNFR_enti_MO000000205
TNFR
TNFR:TRAF6_enti_e21
TNFR:TRAF6
NF-kappaB_enti_MO000000058
NF-kappaB
NF-kappaB{active}_enti_e22
NF-kappaB{active}
NF-kappaB{active}_enti_e23
NF-kappaB{active}
MAPKs_enti_MO000000077
MAPKs
MAPKs{active}_enti_e24
MAPKs{active}
Raf_enti_MO000000009
Raf
Raf{active}_enti_e25
Raf{active}
MEK{active}_enti_MO000000018
MEK{active}
MEK_enti_e26
MEK
MAPKs{active}_enti_e27
MAPKs{active}
STAT3_enti_e28
STAT3
C/EBPbeta_enti_e29
C/EBPbeta
C/EBPbeta{p}_enti_e30
C/EBPbeta{p}
NF-M_enti_e31
NF-M
C/EBP family proteins_enti_e32
C/EBP family proteins
Myeloid specific genes_enti_e33
Myeloid specific genes