1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/10380893.csml convertedTime:2009.07.01.10:37

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Monocyte CD14: a multifunctional receptor engaged in apoptosis from both sides.
Authors Heidenreich S.
Affiliation Department of Medicine, University of Munster, Germany. heidenr@uni-muenster.de
Abstract Like all other immune system cells, monocytes and macrophages may undergoapoptotic cell death in response to specific triggers and mediators or as aconsequence of aging. However, factors inducing apoptosis and the involvedcellular and molecular mechanisms are much better investigated and understoodfor lymphocytes. Th2 cell-derived cytokines such as interleukin-4 (IL-4) areable to induce monocyte apoptosis most effectively. This process is preceded bydown-regulation of the CD14 surface receptor. Mediators such aslipopolysaccharide (LPS) suppress and postpone apoptosis in parallel withup-regulation of CD14. Macrophages are rather resistant against apoptoticdamage, and factors able to evoke apoptosis in monocytes are often ineffectivein macrophages. Resistance of macrophages against apoptotic triggers may bebeneficial for inflammatory processes where macrophages are engaged and neededas phagocytes for ingestion and removal of moribund cells. The multifunctionalCD14 receptor of monocytes/macrophages is supposed to be involved in theapoptotic network on both sides: as a surface molecule of monocytes that canpromote survival and antagonize apoptosis and as a recognition receptor ofmacrophages that enables or supports interaction with apoptotic cells.
PMID 10380893
Model Abstract

Entity

G010329:TNF-alpha G010389:IL-1beta G011389:CD14 MO000000011:ERK MO000000022:p38 MO000000087:IL-2R complexes MO000000214:IL-1 MO000000289:TNF-alpha MO000004927:Fas MO000007321:IL-13 MO000016597:IL-1beta MO000016828:Caspase-1 MO000016882:LPS MO000016922:CD40 MO000016931:FasL MO000017053:IL-4 MO000017059:IL-4R MO000017061:IL-2 MO000017247:IL-10 MO000017252:IL-10R MO000017264:IL-8 MO000018132:CD14 MO000018229:proCaspase-1 MO000019397:TLR2 MO000019420:LBP MO000019449:proIL-1beta MO000034204:IL-13R MO000038306:ERK{p} e1: e10: e11:IL4-IL4R e12:IL-8 e13:IL10-IL10R e14:FasL:Fas e15:ROI e17:LPS:CD14 e18:IgM e19:NF-kappaB{active} e2: e20:NF-kappaB e21:anti-CD14 e22:anti-CD14:CD14 e23:Ca2+ e24:IL-2:IL-2R e25:muramyl dipeptide e26:muramyl peptide:CD14 e27:peptidoglycan e28:peptidoglycan:CD14 e29:lipoarabinomannan e3: e30:e30 e31:Phospholipids e32:Phospholipids:CD14 e33:p38{p} e34:NF-kappaB{active} e35:LPS:CD14:TLR2 e36:TNF-alpha:TNFR e37:TNFR e38:IL-1R e39:IL-1:IL-1R e4: e40:IL-13:IL-13R e41:unknown receptor e42:phosphatidyl serine e43:phosphatidyl serine:unknown receptor e44:CD36:alpha5beta3 integrin e45:thrombospondin e46:thrombospondin:CD36:alpha5beta3 integrin e5:CD40L e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:CD40L:CD40 e60: e61: e62: e65: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p25 p26 p27 p28 p29 p30 p32 p33 p34 p35 p36 p38 p39 p4 p40 p5 p6 p8 p9
Model Detail
665.0, 1281.0
46.0, 46.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
710.0, 906.0
36.0, 36.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
557.0, 1093.0
38.0, 38.0

CD14

--

G011389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p32 p34 p36

--

true true true true

csml-variable:Double

m94268

10

false

infinite

0

unit false false false
TRANSFACG011389

--

Go back
504.0, 360.0
32.0, 32.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
422.0, 402.0
36.0, 36.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
297.0, 869.0
38.0, 38.0

IL-2R complexes

--

MO000000087

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m78

10

false

infinite

0

unit false false false
TRANSPATHMO000000087

--

Go back
167.0, 1111.0
42.0, 42.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
1288.0, 1204.0
40.0, 40.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
1189.0, 329.0
38.0, 38.0

Fas

--

MO000004927

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m580

10

false

infinite

0

unit false false false
InterProIPR001368
TRANSPATHMO000004927

--

Go back
123.0, 635.0
42.0, 42.0

IL-13

--

MO000007321

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m836

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000007321

--

Go back
1351.0, 615.0
34.0, 34.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2 p19

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
825.0, 465.0
30.0, 30.0

Caspase-1

--

MO000016828

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

--

true true true true

csml-variable:Double

m1765

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
1458.0, 450.0
36.0, 36.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1183.0, 143.0
50.0, 50.0

CD40

--

MO000016922

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m1837

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000016922

--

Go back
1305.0, 189.0
38.0, 38.0

FasL

--

MO000016931

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m1844

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000016931

--

Go back
1367.0, 755.0
33.0, 33.0

IL-4

--

MO000017053

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m1947

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000017053

--

Go back
1189.0, 700.5
38.5, 38.5

IL-4R

--

MO000017059

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m1952

10

false

infinite

0

unit false false false
TRANSPATHMO000017059

--

Go back
138.0, 870.0
35.0, 35.0

IL-2

--

MO000017061

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m1954

10

false

infinite

0

unit false false false
TRANSPATHMO000017061

--

Go back
1515.0, 879.0
42.0, 42.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
1182.0, 878.0
44.0, 44.0

IL-10R

--

MO000017252

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m2108

10

false

infinite

0

unit false false false
TRANSPATHMO000017252

--

Go back
1338.0, 1102.0
44.0, 44.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

--

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
1180.0, 496.0
40.0, 40.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
631.0, 463.0
34.0, 34.0

proCaspase-1

--

MO000018229

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m2906

10

false

infinite

0

unit false false false
InterProIPR001309
TRANSPATHMO000018229

--

Go back
1172.0, 1156.0
48.0, 48.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
1427.0, 575.0
42.0, 42.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
579.0, 614.5
34.5, 34.5

proIL-1beta

--

MO000019449

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m4012

10

false

infinite

0

unit false false false
InterProIPR003297
TRANSPATHMO000019449

--

Go back
289.0, 633.0
46.0, 46.0

IL-13R

--

MO000034204

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m12757

10

false

infinite

0

unit false false false
TRANSPATHMO000034204

--

Go back
512.0, 556.0
40.0, 40.0

ERK{p}

--

MO000038306

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

--

true true true true

csml-variable:Double

m16522

10

false

infinite

0

unit false false false
TRANSPATHMO000038306

--

Go back
276.84730964531, 85.86023695498149
954.3416585288205, 1385.7040881838468

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
286.0423250766088, 107.04008230026119
925.0493118020737, 1301.2842721126042

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1176.5, 798.0
31.0, 60.0

IL4-IL4R

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
870.0, 1160.0
60.0, 32.0

IL-8

--

e12

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p17

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1176.5, 990.0
31.0, 60.0

IL10-IL10R

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1188.5, 414.0
31.0, 60.0

FasL:Fas

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
874.0, 179.0
60.0, 34.0

ROI

--

e15

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1188.5, 562.0
31.0, 60.0

LPS:CD14

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
787.0, 1040.4948096885814
57.19723183391003, 30.505190311418687

IgM

--

e18

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p12

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
795.0, 772.8217951298047
49.748440330046286, 30.678204870195213

NF-kappaB{active}

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
276.84730964531, 85.86023695498149
954.3416585288205, 1385.7040881838468

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
631.0, 728.8217951298047
49.748440330046286, 30.678204870195213

NF-kappaB

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1512.0, 256.3846153846153
31.076923076923084, 46.615384615384606

anti-CD14

--

e21

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p15 p17 p19

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
936.5, 86.0
31.0, 60.0

anti-CD14:CD14

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
570.5, 262.01638186696795
39.577743256602176, 40.24855246434119

Ca2+

--

e23

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
308.5, 1026.0
31.0, 60.0

IL-2:IL-2R

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
846.0, 27.0
60.0, 34.0

muramyl dipeptide

--

e25

cso30:c:SmallMolecule

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p20

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
780.5, 90.0
31.0, 60.0

muramyl peptide:CD14

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
542.0, 19.0
60.0, 34.0

peptidoglycan

--

e27

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p21

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
640.5, 94.0
31.0, 60.0

peptidoglycan:CD14

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p21

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
366.0, 19.0
60.0, 34.0

lipoarabinomannan

--

e29

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p22

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
295.9341428158865, 104.94707012555794
916.1679921876677, 1347.5304218426938

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
492.5, 90.0
31.0, 60.0

e30

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p22

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
244.0, 36.75946173254837
55.13036164844407, 31.24053826745164

Phospholipids

--

e31

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p23

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
352.5, 94.0
31.0, 60.0

Phospholipids:CD14

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p23

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
418.0, 554.1707317073171
43.536585365853654, 34.829268292682926

p38{p}

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

p25

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
615.0, 988.8217951298047
49.748440330046286, 30.678204870195213

NF-kappaB{active}

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

p29

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1174.5, 1270.0
43.0, 60.0

LPS:CD14:TLR2

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
996.5, 1402.0
31.0, 60.0

TNF-alpha:TNFR

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1168.5, 1374.0
39.0, 60.0

TNFR

--

e37

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p33

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
284.5, 1118.0
39.0, 60.0

IL-1R

--

e38

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p35

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
292.5, 1230.0
31.0, 60.0

IL-1:IL-1R

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
331.2447841814529, 138.3490281740664
845.5467094565352, 1280.7265057456755

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
292.5, 730.0
31.0, 60.0

IL-13:IL-13R

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
296.5, 230.0
39.0, 60.0

unknown receptor

--

e41

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p39

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
110.0, 243.0
60.0, 34.0

phosphatidyl serine

--

e42

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p39

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
296.5, 338.0
31.0, 60.0

phosphatidyl serine:unknown receptor

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p39

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
296.5, 437.90401908607083
38.05211965498256, 53.09598091392917

CD36:alpha5beta3 integrin

--

e44

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p40

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
80.0, 464.45079086116
47.76801405975395, 31.049209138840062

thrombospondin

--

e45

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p40

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
290.0, 534.0
36.0, 60.0

thrombospondin:CD36:alpha5beta3 integrin

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p40

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1306.0, 111.22934973637962
52.72407732864675, 34.27065026362039

CD40L

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
478.85901230263585, 884.9941151544053
518.9890409938839, 470.66603903914665

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
534.9136945701318, 896.1482160388382
303.4684522757533, 456.1691384527253

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
485.62423257629916, 891.2761054085213
505.45860044655774, 458.102058530915

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
486.5906926153939, 892.2425654476162
503.52568036836794, 456.1691384527253

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
478.85901230263585, 884.9941151544053
518.9890409938839, 470.66603903914665

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
478.85901230263585, 884.9941151544053
518.9890409938839, 470.66603903914665

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
486.5906926153939, 892.2425654476162
503.52568036836794, 456.1691384527253

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
857.71134762778, 1078.2861229733567
32.42358369389784, 29.351875765002312

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
772.6628641874415, 1213.590528446622
91.81370371400179, 83.11556336214913

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
478.85901230263585, 884.9941151544053
518.9890409938839, 470.66603903914665

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1188.5, 246.0
31.0, 60.0

CD40L:CD40

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
601.1818091145595, 1094.154213757905
16.43562035398432, 7.913446837103572

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
600.6329772285751, 1070.5544426605984
56.25526831334568, 101.25948296402233

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
624.2327483258817, 1136.4142689786622
8.781310175741762, 8.781310175741774

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1318.4957254920382, 96.86128986800695
99.00427450796185, 143.13871013199307

--

e65

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false true false

--

Go back
289.3859670516266, 91.43641975017812
935.9118431417663, 1326.162906887226

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
292.72960902664454, 114.84191357530278
897.8313832365059, 1303.6511684594072

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
301.6459876266918, 138.24740740042745
893.7322904806382, 1286.554110050487

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
726.0, 470.0
19.0, 19.0

p1

p1

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c1 : 1
stoichiometry:c2 : 1

m17*m2906*0.1

nodelay

--

true

0

false

PMID: 10380893, 9427712 In monocytic THP-1 cells LPS was able to activate caspase-1, a cysteine protease involved in different apoptotic processes.

Go back
973.0, 181.0
30.0, 30.0

p10

p10

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c27 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 10380893 It was pointed out that reactive oxygen intermediates (ROI) play a central role as downstream mediators of Fasinduced monocyte apoptosis.

Go back
1277.0, 505.0
21.0, 21.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c39 : 1
stoichiometry:c33 : 1

m2828*m155666*m3985*0.1

nodelay

--

true

0

false

PMID: 10380893, 1698311 In 1990 CD14 putative main function as a receptor for LPS was discovered with the help of specific monoclonal antibodies (mAb). PMID: 10380893, 2402637 LPS binds to CD14 in a native state or in aggregates and a 60-kDa serum glycoprotein, named LPS-binding protein (LBP), highly enhances binding to the CD14 receptor.

Go back
805.0, 952.0
23.0, 23.0

p12

p12

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m17*m19*0.1

nodelay

--

true

0

false

PMID: 10380893, 1375269 In murine 70 Z/3 B cells, LPS responsiveness was enhanced 1000-fold as measured by nuclear factor-kB (NF-kB) -regulated rise of IgM expression.

Go back
760.0, 732.0
23.0, 23.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c40 : 1
stoichiometry:c38 : 1

m20*m17*0.1

nodelay

--

true

0

false

PMID: 10380893, 7534294 Gregner et al. could show that LPS signal transduction and LPS clearance or internalization utilized both membrane-bound CD14 (mCD14) and LBP but signal transduction pathways, e.g., NF-kB activation, diverged after the initial complex was formed.

Go back
1398.0, 382.0
27.0, 27.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m21*m2828*0.1

nodelay

--

true

0

false

PMID: 10380893, 2466895 Ca2+ mobilization in activated monocytes can be induced by the CD14 molecule via cross-linking of anti-CD14 antibody Fc receptors or F(ab)¡Ç2 fragments of secondary antibodies.

Go back
715.0, 183.0
25.0, 25.0

p16

p16

cso30:i:ME_ChangeInMaterialConcentration

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c47 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 10380893, 2466895 Ca2+ mobilization in activated monocytes can be induced by the CD14 molecule via cross-linking of anti-CD14 antibody Fc receptors or F(ab)¡Ç2 fragments of secondary antibodies.

Go back
1030.0, 1110.0
28.0, 28.0

p17

p17

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c54 : 1
stoichiometry:c59 : 1
stoichiometry:c50 : 1

m12*m24*0.1

nodelay

--

true

0

false

PMID: 10380893 This was shown by blocking IL-8 and IL-1b secretion induced by IL-2 with anti-CD14 mAbs as well as by transfecting U937 cells with CD14 cDNA and thus up-regulating monokine synthesis in response to IL-2.

Go back
219.0, 823.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m1954*m78*0.1

nodelay

--

true

0

false

PMID: 10380893 This was shown by blocking IL-8 and IL-1b secretion induced by IL-2 with anti-CD14 mAbs as well as by transfecting U937 cells with CD14 cDNA and thus up-regulating monokine synthesis in response to IL-2.

Go back
999.0, 875.0
25.0, 25.0

p19

p19

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c30 : 1
stoichiometry:c41 : 1
stoichiometry:c56 : 1

m93364*m24*0.1

nodelay

--

true

0

false

PMID: 10380893 This was shown by blocking IL-8 and IL-1b secretion induced by IL-2 with anti-CD14 mAbs as well as by transfecting U937 cells with CD14 cDNA and thus up-regulating monokine synthesis in response to IL-2. PMID: 10380893 Only IL-4 blocked CD40-dependent rescue from apoptosis, although both cytokines decreased IL-1b synthesis after receptor ligation.

Go back
767.0, 619.0
25.0, 25.0

p2

p2

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m4012*0.1

nodelay

--

true

0

false

PMID: 10380893 Cleavage of the IL-1b precursor protein was followed by release of mature IL-1b with putative secondary consequences for the antagonism of cell death.

Go back
767.0, 31.0
25.0, 25.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c62 : 1
stoichiometry:c61 : 1

m25*m2828*0.1

nodelay

--

true

0

false

PMID: 10380893, 7534618 purified lipophilic or polysaccharide components such as muramyl dipeptide, peptidoglycan, lipoarabinomannan, or phospholipids interact with CD14, suggesting that CD14 acts not only as a surface receptor for LPS but might function as a polyspecific receptor with broad recognition properties.

Go back
644.0, 24.0
23.0, 23.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c65 : 1
stoichiometry:c64 : 1

m27*m2828*0.1

nodelay

--

true

0

false

PMID: 10380893, 7534618 purified lipophilic or polysaccharide components such as muramyl dipeptide, peptidoglycan, lipoarabinomannan, or phospholipids interact with CD14, suggesting that CD14 acts not only as a surface receptor for LPS but might function as a polyspecific receptor with broad recognition properties.

Go back
454.0, 34.0
27.0, 27.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c68 : 1
stoichiometry:c67 : 1

m29*m2828*0.1

nodelay

--

true

0

false

PMID: 10380893, 7534618 purified lipophilic or polysaccharide components such as muramyl dipeptide, peptidoglycan, lipoarabinomannan, or phospholipids interact with CD14, suggesting that CD14 acts not only as a surface receptor for LPS but might function as a polyspecific receptor with broad recognition properties.

Go back
238.0, 114.0
19.0, 19.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c6 : 1
stoichiometry:c70 : 1

m31*m2828*0.1

nodelay

--

true

0

false

PMID: 10380893, 7534618 purified lipophilic or polysaccharide components such as muramyl dipeptide, peptidoglycan, lipoarabinomannan, or phospholipids interact with CD14, suggesting that CD14 acts not only as a surface receptor for LPS but might function as a polyspecific receptor with broad recognition properties.

Go back
428.0, 484.0
23.0, 23.0

p25

p25

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c74 : 1

m33*m17*0.1

nodelay

--

true

0

false

PMID: 10380893, 7914033, 7992057 Monocyte activation by LPS induces a rapid increase of tyrosine phosphorylation in different proteins belonging to the MAP kinase family such as p38 or ERK.

Go back
508.0, 452.0
23.0, 23.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m35*m17*0.1

nodelay

--

true

0

false

PMID: 10380893, 7914033, 7992057 Monocyte activation by LPS induces a rapid increase of tyrosine phosphorylation in different proteins belonging to the MAP kinase family such as p38 or ERK.

Go back
1005.0, 1209.0
30.0, 30.0

p27

p27

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c88 : 1
stoichiometry:c80 : 1

m93309*m37*0.1

nodelay

--

true

0

false

PMID: 10380893 wild-type LPS activated the cytokine production (e.g., TNF-a) and translocated NF-kB in a TLR2-dependent manner.

Go back
553.0, 1209.0
30.0, 30.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c81 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 10380893 wild-type LPS activated the cytokine production (e.g., TNF-a) and translocated NF-kB in a TLR2-dependent manner.

Go back
622.0, 846.0
19.0, 19.0

p29

p29

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c89 : 1
stoichiometry:c83 : 1

m19*m37*0.1

nodelay

--

true

0

false

PMID: 10380893 wild-type LPS activated the cytokine production (e.g., TNF-a) and translocated NF-kB in a TLR2-dependent manner.

Go back
1454.0, 1166.0
27.0, 27.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m3964*m17*0.1

nodelay

--

true

0

false

PMID: 10380893 wild-type LPS activated the cytokine production (e.g., TNF-a) and translocated NF-kB in a TLR2-dependent manner.

Go back
651.0, 1055.0
25.0, 25.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c10 : 1
stoichiometry:c29 : 1
stoichiometry:c92 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 10380893 Parallel to increased CD14 expression due to LPS administration, apoptosis was inhibited, whereas decreased expression after IL-4 treatment was associated with induction of apoptosis.

Go back
1389.0, 1274.0
21.0, 21.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c98 : 1
stoichiometry:c95 : 1

m230*m39*0.1

nodelay

--

true

0

false

PMID: 10380893, 7682078 Cytokines such as TNF-a or IL-1 with their well-known effects of enhancing survival of monocytes also increase CD14 expression.

Go back
688.0, 1156.0
23.0, 23.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c16 : 1
stoichiometry:c22 : 1
stoichiometry:c97 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 10380893, 7682078 Cytokines such as TNF-a or IL-1 with their well-known effects of enhancing survival of monocytes also increase CD14 expression. PMID: 10380893 Parallel to increased CD14 expression due to LPS administration, apoptosis was inhibited, whereas decreased expression after IL-4 treatment was associated with induction of apoptosis.

Go back
219.0, 1183.0
25.0, 25.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m185*m40*0.1

nodelay

--

true

0

false

PMID: 10380893, 7682078 Cytokines such as TNF-a or IL-1 with their well-known effects of enhancing survival of monocytes also increase CD14 expression.

Go back
516.0, 1176.0
23.0, 23.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c15 : 1
stoichiometry:c17 : 1
stoichiometry:c102 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 10380893, 7682078 Cytokines such as TNF-a or IL-1 with their well-known effects of enhancing survival of monocytes also increase CD14 expression. PMID: 10380893 Parallel to increased CD14 expression due to LPS administration, apoptosis was inhibited, whereas decreased expression after IL-4 treatment was associated with induction of apoptosis.

Go back
211.0, 643.0
25.0, 25.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m836*m12757*0.1

nodelay

--

true

0

false

PMID: 10380893, 7545713 IL-13 can evoke apoptosis consecutively to down-regulation of CD14

Go back
223.0, 247.0
25.0, 25.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m43*m44*0.1

nodelay

--

true

0

false

PMID: 10380893, 1545126, 7595231 Phagocyte receptors for phosphatidylserine (PS) have been further described that bind this phospholipid when it comes from the inner to the outer leaflet of the membranes of cells undergoing apoptosis.

Go back
1280.0, 160.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m1837*m5*0.1

nodelay

--

true

0

false

PMID: 10380893 Activation of monocytes can also be achieved through the interaction between monocytic CD40 with the CD40 ligand present on activated lymphocytes.

Go back
184.0, 452.0
23.0, 23.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m47*m46*0.1

nodelay

--

true

0

false

PMID: 10380893, 1688647, 7536797 The first and best established receptor complex comprises the avb3 vitronectin receptor integrin and CD36, which belongs to class B scavenger receptors and can bind thrombospondin.

Go back
1286.0, 762.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m1952*m1947*0.1

nodelay

--

true

0

false

PMID: 10380893 Only IL-4 blocked CD40-dependent rescue from apoptosis, although both cytokines decreased IL-1b synthesis after receptor ligation.

Go back
716.0, 848.0
23.0, 23.0

p6

p6

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c23 : 1
stoichiometry:c14 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 10380893 Only IL-4 blocked CD40-dependent rescue from apoptosis, although both cytokines decreased IL-1b synthesis after receptor ligation.

Go back
1410.0, 890.0
19.0, 19.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m2108*m2103*0.1

nodelay

--

true

0

false

PMID: 10380893 Only IL-4 blocked CD40-dependent rescue from apoptosis, although both cytokines decreased IL-1b synthesis after receptor ligation.

Go back
1355.0, 335.0
25.0, 25.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m580*m1844*0.1

nodelay

--

true

0

false

PMID: 10380893, 7532907 The Fas (APO-1,CD95)/Fas ligand (FasL) system has been established as a central pathway for the induction of lymphocyte apoptosis acting from the cell surface site

Go back
665.0, 480.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
324.0, 773.0

c10

c10

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
250.68136691855904, 1161.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.0, 1206.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 1137.7924528301887

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
324.0, 1194.4941633431786

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
165.0, 656.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.0, 656.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
234.0, 668.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.0, 260.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1228.0, 731.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
170.0, 260.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
245.0, 272.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
128.0, 467.40632510786924

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
215.0, 464.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
207.0, 474.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1313.0, 772.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1215.0059311099424, 777.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.0, 871.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
323.0, 790.0

c15

c15

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
324.0, 776.0

c16

c16

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
542.5162057156793, 836.0

c17

c17

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
742.9906502606938, 829.0

c18

c18

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1226.0, 900.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
745.0, 480.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1437.0, 900.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1215.0694518625803, 905.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
714.2941037900142, 839.0

c22

c22

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
742.7815836679695, 865.3036966526562

c23

c23

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1227.0, 348.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1330.0, 227.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1226.904659553595, 356.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
942.0, 196.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1006.2660535029922, 217.02234842097522

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
679.6407189396797, 835.0

c29

c29

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
752.7813200240378, 483.85770252826126

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1027.227630827177, 899.3627101479989

c30

c30

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1220.0, 516.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1305.7611400011626, 473.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1225.9101281982717, 526.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
833.7755726234382, 607.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
816.1230623603457, 975.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
817.1621288575177, 804.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
681.0, 744.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
783.0, 754.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1305.1664938655608, 524.5554698247743

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
614.0, 632.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.5456366699534, 597.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1027.794733192202, 833.0

c41

c41

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1430.6568542494924, 296.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1220.0, 407.9480450613707

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
974.8317469842665, 129.16259932529726

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
616.8021211735029, 204.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
747.538254191714, 122.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
930.0, 1131.7097557461818

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
792.0, 632.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1058.0, 1124.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
173.0, 849.4708276965785

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.79117527163274, 847.22846762196

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
237.0, 848.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 1057.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
746.0, 891.0038598182887

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1024.0, 648.6686790166359

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 892.8986355666997

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1025.5887491543285, 299.0

c58

c58

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1053.9905717805289, 303.0

c59

c59

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
264.3975907622342, 131.04559533006392

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
800.0, 44.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
782.0, 56.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.3140670806431, 61.98002433627362

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
602.0, 36.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.0, 47.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
673.0024573927325, 51.28871489574088

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.0, 41.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.0, 61.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
487.73974674361926, 60.309966801713614

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
253.62816499953018, 68.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1233.0, 169.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
257.0, 124.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
440.0, 438.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
440.0, 507.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
458.9372262668618, 498.0002195702143

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
520.0, 392.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.863788072701, 467.4699786214927

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.0, 475.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
711.0, 1229.8529642184483

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1308.4436087949382, 146.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1035.0, 1224.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
583.0, 1234.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
648.5183473879075, 797.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.0, 865.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1220.0, 1180.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1217.0, 622.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1225.3092146592892, 1186.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.9430781793684, 1226.9526326870525

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1042.3340596553226, 1233.195554564105

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
647.2880942641693, 867.945692117886

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1225.1455366913863, 183.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
602.1554175279994, 1075.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
682.0082631656993, 606.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1328.0, 1237.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1035.4795062862913, 1289.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.1070902829529, 1182.1675379317294

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
602.2909647972695, 1124.292693779412

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1208.0, 1294.927573183681

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
202.0, 1153.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back