1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/10473535.csml convertedTime:2009.07.01.10:37

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The oxidation of lipoproteins by monocytes-macrophages. Biochemical andbiological mechanisms.
Authors Chisolm GM 3rd, Hazen SL, Fox PL, Cathcart MK.
Affiliation Department of Cell Biology, Lerner Research Institute, Cleveland ClinicFoundation, Cleveland, Ohio 44195, USA. chisolg@ccf.org
Abstract
PMID 10473535
Model Abstract

Entity

MO000000290:LDL MO000016723:PLA2 MO000107436:oxLDL e1: e10: e11:Zymosan e12:ceruloplasmin e13:endotoxin e14:IFN-gamma e15:15-lipoxygenase e16:angiotensin-II e17:Fatty acids e18:hydroperoxides e19:LO e2: e20:tyrosyl radical e21:L-tyrosine e22:MPO e23:chloride e24:HOCL e3: e4: e5:ceruloplasmin e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:O2- e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p2 p3 p4 p5 p6 p7 p8 p9
Model Detail
515.0, 535.0
26.0, 26.0

LDL

--

MO000000290

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p7 p8 p12

true true true true

csml-variable:Double

m290118

10

false

infinite

0

unit false false false
TRANSPATHMO000000290

--

Go back
878.0, 662.0
28.0, 28.0

PLA2

--

MO000016723

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m1675

10

false

infinite

0

unit false false false
InterProIPR001211
TRANSPATHMO000016723

--

Go back
852.0, 532.0
32.0, 32.0

oxLDL

--

MO000107436

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1 p2 p7 p8 p12

--

true true true true

csml-variable:Double

m341431

10

false

infinite

0

unit false false false
TRANSPATHMO000107436

--

Go back
239.75, 164.9969080091176
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
248.0, 184.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
639.5, 693.3221976252767
17.684644797746028, 28.677802374723292

Zymosan

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2 p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
628.0, 1077.2145328719726
40.84775086505191, 21.785467128027683

ceruloplasmin

--

e12

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p3

p4 p5 p6

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
150.0, 639.3212783851976
45.315391084945325, 25.678721614802352

endotoxin

--

e13

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
165.0, 895.1309635173059
21.609915809167447, 49.869036482694106

IFN-gamma

--

e14

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
796.0, 732.255282753069
39.3157576977259, 24.244717246930975

15-lipoxygenase

--

e15

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7 p8 p12

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1126.0, 608.1045694200352
35.99297012302284, 23.395430579964856

angiotensin-II

--

e16

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
368.0, 326.3490328006729
47.031118587047935, 26.650967199327166

Fatty acids

--

e17

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
604.0, 326.19175777964676
47.308662741799836, 26.80824222035324

hydroperoxides

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
472.0, 243.33940430670145
40.80096598913263, 25.16059569329845

LO

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
239.75, 164.9969080091176
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
924.0, 266.677039529016
48.21698906644238, 27.32296047098402

tyrosyl radical

--

e20

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
716.0, 268.8662741799832
40.8242220353238, 23.133725820016817

L-tyrosine

--

e21

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
887.0, 367.3536014967259
18.046772684752103, 41.646398503274085

MPO

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10 p11

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
316.5, 368.18246010450514
31.287247563903406, 31.817539895494985

chloride

--

e23

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
466.5, 441.97740432142393
19.68888575060019, 20.022595678576458

HOCL

--

e24

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p11

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
256.875188623529, 182.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
288.5567875770579, 212.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
673.0, 424.81999999999994
30.239999999999995, 22.68

ceruloplasmin

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

p4 p5 p6

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
421.0, 882.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
471.29367619468036, 892.0077409313899
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
427.06992643728904, 887.6363602631968
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
427.93705878547314, 888.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
421.0, 882.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
421.0, 882.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
427.93705878547314, 888.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
760.9158804881849, 1055.426469636829
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
684.6082338479803, 1176.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
421.0, 882.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
789.5, 449.1471543567294
21.488631549216226, 21.852845643270733

O2-

--

e6

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
530.7511016961721, 1069.6637213250547
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
530.2586758712023, 1048.489410851356
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
551.4329863449013, 1107.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
251.0, 170.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
254.0, 191.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
262.0, 212.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
676.0, 536.0
23.0, 23.0

p1

p1

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

MO000000290 e5 e6

MO000107436

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c3 : 1
stoichiometry:c4 : 1
stoichiometry:c2 : 1

m290118*m5*m6*0.1

nodelay

--

true

0

false

PMID: 10473535, 8663020 Cp markedly enhanced LDL oxidation by both cell types. PMID: 10473535 Cell-derived superoxide anion (Obardot 2) was essential for the enhancement of LDL oxidation by Cp under these conditions.

Go back
822.0, 270.0
19.0, 19.0

p10

p10

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

e21 e22

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c30 : 1

m21*m22*0.1

nodelay

--

true

0

false

PMID: 10473535 MPO can catalyze the one-electron oxidation of L-tyrosine, generating the tyrosyl radical.

Go back
466.0, 374.0
19.0, 19.0

p11

p11

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

e23 e22

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c34 : 1
stoichiometry:c33 : 1

m23*m22*0.1

nodelay

--

true

0

false

PMID: 10473535 MPO catalyzes the two-electron oxidation of chloride forming the powerful oxidant, hypochlorous acid (HOCl).

Go back
681.0, 697.0
21.0, 21.0

p7

p12

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

MO000000290 e15

MO000107436

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c37 : 1
stoichiometry:c36 : 1

m290118*m15*0.1

nodelay

--

true

0

false

PMID: 10473535, 3139813, 1901344 Incubation of LDL with 15-LO plus phospholipase A2 led to LDL oxidation in a cell-free system; however, 15-LO alone was also shown to oxidize LDL significantly in the absence of cells.

Go back
642.0, 634.0
19.0, 19.0

p2

p2

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

MO000000290 e11

MO000107436

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c7 : 1
stoichiometry:c6 : 1

m290118*m11*0.1

nodelay

--

true

0

false

PMID: 10473535, 8609249 Exogenous Cp added to unactivated U937 cells caused LDL oxidation to an extent similar to that by zymosan in the absence of exogenous Cp.

Go back
637.0, 945.0
21.0, 21.0

p3

p3

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c10 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 10473535, 8609249 Zymosan induced Cp mRNA and (after a 5-6-h lag following activation) Cp protein synthesis.

Go back
566.0, 818.0
19.0, 19.0

p4

p4

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e12

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m12*0.1

nodelay

--

true

0

false

--

Go back
488.0, 764.0
23.0, 23.0

p5

p5

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e12 e13

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c17 : 1
stoichiometry:c13 : 1

m12*m13*0.1

nodelay

--

true

0

false

PMID: 10473535, 1996664, 9257859 Factors that stimulate monocyte-macrophage Cp production and could contribute to Cp accumulation in vivo include endotoxin and interferon (IFN)-gamma.

Go back
358.0, 750.0
19.0, 19.0

p6

p6

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e12 e14

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c14 : 1

m12*m14*0.1

nodelay

--

true

0

false

PMID: 10473535, 1996664, 9257859 Factors that stimulate monocyte-macrophage Cp production and could contribute to Cp accumulation in vivo include endotoxin and interferon (IFN)-gamma.

Go back
717.0, 573.0
21.0, 21.0

p7

p7

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

MO000000290 e15 MO000016723

MO000107436

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c19 : 1

m290118*m15*m1675*0.1

nodelay

--

true

0

false

PMID: 10473535, 3139813, 1901344 Incubation of LDL with 15-LO plus phospholipase A2 led to LDL oxidation in a cell-free system; however, 15-LO alone was also shown to oxidize LDL significantly in the absence of cells.

Go back
710.0, 650.0
19.0, 19.0

p8

p8

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

MO000000290 e15 e16

MO000107436

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c23 : 1

m290118*m15*m16*0.1

nodelay

--

true

0

false

PMID: 10473535, 3139813, 1901344 Incubation of LDL with 15-LO plus phospholipase A2 led to LDL oxidation in a cell-free system; however, 15-LO alone was also shown to oxidize LDL significantly in the absence of cells. PMID: 10473535, 9261183 Angiotensin II enhanced both LO activity and LDL oxidation in mouse peritoneal macrophages and J774 cells.

Go back
524.0, 328.0
23.0, 23.0

p9

p9

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

e17 e19

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c28 : 1
stoichiometry:c27 : 1

m17*m19*0.1

nodelay

--

true

0

false

PMID: 10473535 They catalyze the direct insertion of molecular oxygen into polyenoic fatty acids, forming hydroperoxides.

Go back
541.0, 548.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
648.0, 966.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
648.0, 722.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.4375346821403, 794.2238047668167

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
507.0, 454.00365453448956

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
377.0, 452.6941919946304

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
381.1949350435189, 775.0838022562883

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
187.0, 773.1320576475059

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
195.0, 660.0

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
541.0, 550.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.0, 553.9722729321518

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.0, 548.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.8592480260213, 601.0075819419861

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
744.9885438102705, 593.8936172657221

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
541.0, 556.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
729.0, 564.824866198974

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
735.0509053796171, 673.2332154634527

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
736.9654805077413, 622.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
415.0, 340.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
547.0, 340.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
499.0, 268.0

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
757.0, 280.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
688.0, 447.0

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
841.0, 280.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.0918708781414, 295.87434307527764

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
348.0, 384.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.0, 393.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.9996039996038, 384.0795980497473

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
541.0, 561.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
702.0, 568.3735111346617

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
709.6890972431105, 713.2085704847233

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
705.3073461315311, 468.0

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
541.0, 558.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
661.0, 558.2526578510723

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
649.0, 660.9900187110228

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.1510844316274, 844.7053770685159

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
579.0, 454.69219158112656

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back