_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e2
_enti_e4
_enti_e3
_enti_e37
_enti_e55
_enti_e35
_enti_e36
_enti_e38
_enti_e53
_enti_e59
_enti_e52
_enti_e51
_enti_e54
_enti_e56
_enti_e50
_enti_e57
_enti_e61
_enti_e58
_enti_e60
_enti_e62
g1_fact_g2
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g14
p1_propro_p1
PMID: 10534106
To activate cells, CpG DNA probably needs to be internalized via the endosomes.
Although internalization of DNA appears to be essential for the biological response, the possibility that a co-stimulatory signal comes from a membrane receptor during the process of internalization should not be
discounted.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputAssociation connector
c5 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 10534106, 9245551, 10689778, 9464831
CpG DNA induces a range of cytokines in macrophages/
dendritic cells, including interleukin-12 (IL-12), tumor
necrosis factor a (TNF-a), IL-1b, and IL-6.
c6 cso30:c:InputAssociation connector
c7 cso30:c:InputAssociation connector
c8 cso30:c:OutputProcess connector
p3_propro_p4
PMID: 10534106, 9245551, 10689778, 9464831
CpG DNA induces a range of cytokines in macrophages/
dendritic cells, including interleukin-12 (IL-12), tumor
necrosis factor a (TNF-a), IL-1b, and IL-6.
c9 cso30:c:InputAssociation connector
c11 cso30:c:InputAssociation connector
c10 cso30:c:OutputProcess connector
p3_propro_p5
PMID: 10534106, 9245551, 10689778, 9464831
CpG DNA induces a range of cytokines in macrophages/
dendritic cells, including interleukin-12 (IL-12), tumor
necrosis factor a (TNF-a), IL-1b, and IL-6.
c12 cso30:c:InputAssociation connector
c14 cso30:c:InputAssociation connector
c13 cso30:c:OutputProcess connector
p3_propro_p6
PMID: 10534106, 9245551, 10689778, 9464831
CpG DNA induces a range of cytokines in macrophages/
dendritic cells, including interleukin-12 (IL-12), tumor
necrosis factor a (TNF-a), IL-1b, and IL-6.
c15 cso30:c:InputAssociation connector
c16 cso30:c:InputAssociation connector
c17 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 10534106, 9568729, 8757335
In comparison to the response to LPS, CpG DNA was as effective
at increasing TNF-a mRNA in bone marrow-derived murine
macrophages, whereas it was a less effective inducer of IL-1b
and plasminogen activator inhibitor type-2 and did not, by
itself, lead to production of inducible nitric oxide synthase
(iNOS)
c3 cso30:c:InputAssociation connector
c4 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 10534106, 9245551, 8648098
In mixed spleen cell culture, CpG DNA-induced
macrophage IL-12 promotes interferon-g production by NK cells
c18 cso30:c:InputProcess connector
c19 cso30:c:InputProcess connector
c20 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 10534106, 9245551, 8648098
In mixed spleen cell culture, CpG DNA-induced
macrophage IL-12 promotes interferon-g production by NK cells
c21 cso30:c:InputAssociation connector
c22 cso30:c:InputAssociation connector
c23 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 10534106, 9568729, 8757335
In comparison to the response to LPS, CpG DNA was as effective
at increasing TNF-a mRNA in bone marrow-derived murine
macrophages, whereas it was a less effective inducer of IL-1b
and plasminogen activator inhibitor type-2 and did not, by
itself, lead to production of inducible nitric oxide synthase
(iNOS)
Interferon-g in turn primes murine macrophages to
respond to CpG DNA with expression of iNOS and nitric oxide
production as well as increasing a number of other responses,
creating a potential self-amplifying loop with NK cells
c26 cso30:c:InputAssociation connector
c27 cso30:c:InputAssociation connector
c28 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 10534106
Interferon-g in turn primes murine macrophages to
respond to CpG DNA with expression of iNOS and nitric oxide
production as well as increasing a number of other responses,
creating a potential self-amplifying loop with NK cells
PMID: 10534106, 1401905
Baccarini et al reported an increase in serine phosphorylation
of the receptor in Bac1.2F5 cells treated with interferon-g
plus LPS.
c24 cso30:c:InputProcess connector
c25 cso30:c:InputProcess connector
c31 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 10534106, 9568729, 8757335
In comparison to the response to LPS, CpG DNA was as effective
at increasing TNF-a mRNA in bone marrow-derived murine
macrophages, whereas it was a less effective inducer of IL-1b
and plasminogen activator inhibitor type-2 and did not, by
itself, lead to production of inducible nitric oxide synthase
(iNOS)
Interferon-g in turn primes murine macrophages to
respond to CpG DNA with expression of iNOS and nitric oxide
production as well as increasing a number of other responses,
creating a potential self-amplifying loop with NK cells
c29 cso30:c:InputAssociation connector
c30 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 10534106, 9568729, 8757335
In comparison to the response to LPS, CpG DNA was as effective
at increasing TNF-a mRNA in bone marrow-derived murine
macrophages, whereas it was a less effective inducer of IL-1b
and plasminogen activator inhibitor type-2 and did not, by
itself, lead to production of inducible nitric oxide synthase
(iNOS)
c32 cso30:c:InputAssociation connector
c33 cso30:c:InputAssociation connector
c34 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c35 cso30:c:InputProcess connector
c36 cso30:c:InputProcess connector
c37 cso30:c:OutputProcess connector
p14_propro_p15
PMID: 10534106, 9799232, 9568729
The latter (MAP kinases) are also activated by CpG DNA in myeloid cells
c47 cso30:c:InputAssociation connector
c48 cso30:c:InputProcess connector
c49 cso30:c:OutputProcess connector
p14_propro_p16
PMID: 10534106, 9799232, 9568729
The latter (MAP kinases) are also activated by CpG DNA in myeloid cells
c44 cso30:c:InputAssociation connector
c45 cso30:c:InputProcess connector
c46 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c50 cso30:c:InputAssociation connector
c51 cso30:c:InputProcess connector
c65 cso30:c:InputInhibitor connector
c52 cso30:c:OutputProcess connector
p14_propro_p19
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c53 cso30:c:InputAssociation connector
c54 cso30:c:InputProcess connector
c66 cso30:c:InputInhibitor connector
c55 cso30:c:OutputProcess connector
p14_propro_p20
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c56 cso30:c:InputAssociation connector
c57 cso30:c:InputProcess connector
c67 cso30:c:InputInhibitor connector
c58 cso30:c:OutputProcess connector
p14_propro_p21
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c59 cso30:c:InputAssociation connector
c60 cso30:c:InputProcess connector
c68 cso30:c:InputInhibitor connector
c61 cso30:c:OutputProcess connector
p14_propro_p22
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c62 cso30:c:InputAssociation connector
c63 cso30:c:InputProcess connector
c69 cso30:c:InputInhibitor connector
c64 cso30:c:OutputProcess connector
p14_propro_p23
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c70 cso30:c:InputAssociation connector
c71 cso30:c:InputProcess connector
c73 cso30:c:InputInhibitor connector
c72 cso30:c:OutputProcess connector
p14_propro_p24
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c74 cso30:c:InputAssociation connector
c75 cso30:c:InputProcess connector
c77 cso30:c:InputInhibitor connector
c76 cso30:c:OutputProcess connector
p14_propro_p25
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c78 cso30:c:InputAssociation connector
c79 cso30:c:InputProcess connector
c81 cso30:c:InputInhibitor connector
c80 cso30:c:OutputProcess connector
p14_propro_p26
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c82 cso30:c:InputAssociation connector
c83 cso30:c:InputProcess connector
c85 cso30:c:InputInhibitor connector
c84 cso30:c:OutputProcess connector
p14_propro_p27
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c86 cso30:c:InputAssociation connector
c87 cso30:c:InputProcess connector
c89 cso30:c:InputInhibitor connector
c88 cso30:c:OutputProcess connector
p14_propro_p28
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c90 cso30:c:InputAssociation connector
c91 cso30:c:InputProcess connector
c93 cso30:c:InputInhibitor connector
c92 cso30:c:OutputProcess connector
p14_propro_p29
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c94 cso30:c:InputAssociation connector
c95 cso30:c:InputProcess connector
c97 cso30:c:InputInhibitor connector
c96 cso30:c:OutputProcess connector
p14_propro_p30
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c98 cso30:c:InputAssociation connector
c99 cso30:c:InputProcess connector
c101 cso30:c:InputInhibitor connector
c100 cso30:c:OutputProcess connector
p14_propro_p31
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c102 cso30:c:InputAssociation connector
c103 cso30:c:InputProcess connector
c105 cso30:c:InputInhibitor connector
c104 cso30:c:OutputProcess connector
p14_propro_p32
PMID: 10534106, 10334979
In the case of LPS signaling, it is now appreciated that such
upstream activators include members of the IL-1 receptor
signaling pathway, such as MyD88, IL-1 receptor-associated
kinases (IRAK) and TRAF 6
PMID: 10534106, 10354505
LPS inhibits its own actions upstream of a
branching point in the signaling cascade for activation of
NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
c106 cso30:c:InputAssociation connector
c107 cso30:c:InputProcess connector
c109 cso30:c:InputInhibitor connector
c108 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 10534106, 9710599
We have demonstrated the constitutive activation of
this pathway in response to CSF-1, and its role in phosphorylation
of the transcription factor Ets2
PMID: 10534106
CSF-1 can activate Raf-1 in a ras-independent
manner.
c129 cso30:c:InputProcess connector
c130 cso30:c:InputProcess connector
c133 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 10534106, 10354505, 6092475, 1401905, 2548952
LPS has been shown previously to cause rapid down-regulation
of CSF-1 binding to murine macrophages
c110 cso30:c:InputInhibitor connector
c114 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 10534106, 10354505, 6092475, 1401905, 2548952
LPS has been shown previously to cause rapid down-regulation
of CSF-1 binding to murine macrophages
c115 cso30:c:InputAssociation connector
c113 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 10534106
Both LPS and bacterial DNA or
CpG oligonucleotides cause rapid down-modulation of the
CSF-1R from the cell surface.
PMID: 10534106, 8497248
Indeed, down-modulation of the
receptor from the cell surface is followed, at least in the case of
LPS, by specific repression of c-fms (CSF-1R) mRNA transcription and RAW264 macrophage cells treated with LPS or
CpG DNA for a prolonged period deplete both their cell surface and intracellular Golgi-associated pool of CSF-1R
c111 cso30:c:InputInhibitor connector
c43 cso30:c:InputInhibitor connector
c112 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 10534106
Both LPS and bacterial DNA or
CpG oligonucleotides cause rapid down-modulation of the
CSF-1R from the cell surface.
c116 cso30:c:InputAssociation connector
c117 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 10534106
The biological importance of the specific internalization of
the CSF-1R in response to CpG DNA and LPS is not known.
c120 cso30:c:InputProcess connector
c122 cso30:c:InputAssociation connector
c121 cso30:c:OutputProcess connector
p39_propro_p40
PMID: 10534106
The biological importance of the specific internalization of
the CSF-1R in response to CpG DNA and LPS is not known.
c123 cso30:c:InputAssociation connector
c124 cso30:c:InputProcess connector
c125 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 10534106, 7799956
More recently the same group claimed that activation
of Raf in LPS-stimulated cells was ras-independent
c126 cso30:c:InputAssociation connector
c127 cso30:c:InputProcess connector
c128 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 10534106
CSF-1 can activate Raf-1 in a ras-independent
manner.
c131 cso30:c:InputProcess connector
c143 cso30:c:InputAssociation connector
c132 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 10534106, 9710599
We have demonstrated the constitutive activation of
this pathway in response to CSF-1, and its role in phosphorylation
of the transcription factor Ets2
c134 cso30:c:InputAssociation connector
c135 cso30:c:InputProcess connector
c136 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 10534106, 9710599
We have demonstrated the constitutive activation of
this pathway in response to CSF-1, and its role in phosphorylation
of the transcription factor Ets2
c144 cso30:c:InputAssociation connector
c145 cso30:c:InputProcess connector
c146 cso30:c:OutputProcess connector
p37_propro_p47
PMID: 10534106
Both LPS and bacterial DNA or
CpG oligonucleotides cause rapid down-modulation of the
CSF-1R from the cell surface.
PMID: 10534106, 8497248
Indeed, down-modulation of the
receptor from the cell surface is followed, at least in the case of
LPS, by specific repression of c-fms (CSF-1R) mRNA transcription and RAW264 macrophage cells treated with LPS or
CpG DNA for a prolonged period deplete both their cell surface and intracellular Golgi-associated pool of CSF-1R
c147 cso30:c:InputAssociation connector
c148 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 10534106, 1401905
Baccarini et al reported an increase in serine phosphorylation
of the receptor in Bac1.2F5 cells treated with interferon-g
plus LPS.
c149 cso30:c:InputProcess connector
c151 cso30:c:InputAssociation connector
c152 cso30:c:InputAssociation connector
c150 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 10534106, 9799232, 9568729
The latter (MAP kinases) are also activated by CpG DNA in myeloid cells
PMID: 10534106, 10586047
More recently, we
confirmed that CpG DNA can mimic the ability of CSF-1 to
activate phosphorylation of the MAP kinases ERK-1 and
ERK-2 in macrophages
c38 cso30:c:InputProcess connector
c40 cso30:c:InputAssociation connector
c39 cso30:c:OutputProcess connector
p17_propro_p18
PMID: 10534106, 9799232, 9568729
The latter (MAP kinases) are also activated by CpG DNA in myeloid cells
PMID: 10534106, 10586047
More recently, we
confirmed that CpG DNA can mimic the ability of CSF-1 to
activate phosphorylation of the MAP kinases ERK-1 and
ERK-2 in macrophages
c41 cso30:c:InputAssociation connector
c42 cso30:c:InputProcess connector
c162 cso30:c:OutputProcess connector
p49_propro_p49
PMID:10534106
One possibility is that after internalization the receptor provides
a CSF-1-independent signal to the ras-raf-MAP kinase
pathway.
c153 cso30:c:InputAssociation connector
c154 cso30:c:InputProcess connector
c155 cso30:c:OutputProcess connector
p49_propro_p50
PMID:10534106
One possibility is that after internalization the receptor provides
a CSF-1-independent signal to the ras-raf-MAP kinase
pathway.
c156 cso30:c:InputAssociation connector
c157 cso30:c:InputProcess connector
c158 cso30:c:OutputProcess connector
p49_propro_p51
PMID:10534106
One possibility is that after internalization the receptor provides
a CSF-1-independent signal to the ras-raf-MAP kinase
pathway.
c159 cso30:c:InputAssociation connector
c160 cso30:c:InputProcess connector
c161 cso30:c:OutputProcess connector
p38_propro_p38
c118 cso30:c:InputProcess connector
c137 cso30:c:InputAssociation connector
c119 cso30:c:OutputProcess connector
p44_propro_p44
c138 cso30:c:InputProcess connector
c140 cso30:c:InputAssociation connector
c139 cso30:c:OutputProcess connector
p45_propro_p45
c141 cso30:c:InputProcess connector
c163 cso30:c:InputAssociation connector
c142 cso30:c:OutputProcess connector
CpG DNA receptor_enti_e13
CpG DNA receptor
CpGDNA_enti_e15
CpGDNA
CpGDNA_enti_e12
CpGDNA
IL-12_enti_MO000017265
IL-12
Il-12_enti_e16
Il-12
TNF-alpha_enti_G010329
TNF-alpha
TNF-alpha_enti_MO000000289
TNF-alpha
IL-1beta_enti_MO000016597
IL-1beta
IL-1beta_enti_G010389
IL-1beta
IL-6_enti_MO000007384
IL-6
IL-6_enti_G010262
IL-6
IL-12R_enti_MO000033676
IL-12R
IL-12:IL-12R_enti_e5
IL-12:IL-12R
IFNgamma_enti_MO000016665
IFNgamma
IFN-gamma_enti_G010453
IFN-gamma
iNOS_enti_MO000021201
iNOS
iNOS_enti_G010514
iNOS
IFNgammaR_enti_e6
IFNgammaR
IFNgamma:R_enti_e11
IFNgamma:R
PAI-2_enti_G010345
PAI-2
PAI-2_enti_e14
PAI-2
NF-kappaB_enti_MO000000058
NF-kappaB
LPS_enti_MO000016882
LPS
TLR4_enti_MO000019394
TLR4
LPS:TLR4_enti_e17
LPS:TLR4
JNK_enti_e18
JNK
p38_enti_e19
p38
ERK1_enti_MO000004670
ERK1
NF-kappaB{active}_enti_e20
NF-kappaB{active}
ERK2_enti_MO000004676
ERK2
ERK2{active}_enti_e21
ERK2{active}
ERK1{active}_enti_e22
ERK1{active}
p38{active}_enti_e23
p38{active}
JNK{active}_enti_e24
JNK{active}
MyD88{active}_enti_MO000016573
MyD88{active}
IRAK{active}_enti_MO000000213
IRAK{active}
TRAF6{active}_enti_MO000000212
TRAF6{active}
M-CSF_enti_MO000000100
M-CSF
M-CSF-1-R_enti_MO000007995
M-CSF-1-R
CSF1_enti_G012247
CSF1
CSF1R_enti_e25
CSF1R
M-CSF-1-R_enti_e26
M-CSF-1-R
Raf_enti_MO000000009
Raf
Raf{active}_enti_e27
Raf{active}
Ras_enti_e28
Ras
Raf-1_enti_MO000000015
Raf-1
Raf-1{active}_enti_e29
Raf-1{active}
MAPKs_enti_MO000000077
MAPKs
M-CSF:M-CSF-1-R_enti_e30
M-CSF:M-CSF-1-R
Ras{active}_enti_e31
Ras{active}
MAPKs{active}_enti_e32
MAPKs{active}
Ets2_enti_e33
Ets2
Ets2{p}_enti_e34
Ets2{p}
M-CSF-1-R_enti_e39
M-CSF-1-R
M-CSF-1-R{p}_enti_e40
M-CSF-1-R{p}
ERK1{p}_enti_e41
ERK1{p}
ERK2{p}_enti_e42
ERK2{p}
MyD88_enti_e43
MyD88
IRAK_enti_e44
IRAK
TRAF6_enti_e45
TRAF6