1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/10611754.csml convertedTime:2009.07.01.10:38

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title TGF-beta signaling from receptors to the nucleus.
Authors Roberts AB.
Affiliation Laboratory of Cell Regulation and Carcinogenesis, National Cancer InstituteBuilding 41, Room C629, 41 Library Drive, MSC 5055, Bethesda, MD 20892-5055,USA.
Abstract In the past three years, a novel signal transduction pathway downstream of thetransforming growth factor-beta (TGF-beta) superfamily receptor serine-threoninekinases has been shown to be mediated by a family of latent transcriptionfactors called 'Smads'. These proteins mediate a short-circuited pathway inwhich a set of receptor-activated Smads are phosphorylated directly by thereceptor kinase and then translocate to the nucleus complexed to the commonmediator, Smad4, to participate in transcriptional complexes. Smads 2 and 3mediate signals predominantly from the TGF-beta receptors. Of these, specificroles have been ascribed to Smad3 in control of chemotaxis of neutrophils andmacrophages and the inhibition of Smad3 activity by the oncogene Evi-1 suggeststhat it may play a role in leukemogenesis. Other data, such as the induction bythe inflammatory cytokine interferon-gamma of an inhibitory Smad, Smad7, whichblocks the actions of Smad3, suggest that identification of the specific genetargets of Smad proteins in immune cells will provide new insight into themechanisms of TGF-beta action on these cells.
PMID 10611754
Model Abstract

Entity

G010646:SMAD7 G010667:SMAD6 MO000000049:c-Jun MO000000071:EGF MO000000077:MAPKs MO000000108:EGFR MO000000279:c-Fos MO000004387:endoglin MO000013604:TGFbeta2 MO000016665:IFNgamma MO000016808:TGFbeta MO000016809:activin MO000016824:Smads MO000017443:TGFbeta1 MO000017445:ALK-5 (2) MO000017450:Smad3 MO000017458:Smad4: Smad4 MO000017658:Smad2 MO000017659:SARA MO000017720:ALK-1 (2) MO000017729:BMP2 MO000017733:TGFbetaR-III (2) MO000017762:Smad1 MO000017768:HGF MO000018970:E1A MO000019248:TGFbeta3 MO000118339:Tbr-1 e1: e10: e11:TGFbeta: TBR2 (2) e12:TGFbeta: TBR2 (2): ALK-1(2) e13:TGFbeta: TBR2 (2): ALK-5(2) e14:TGFbeta3: TBR2 (2): TGFbetaR-III (2) e15:TGFbeta1: TBR2 (2) e16:TGFbeta2: TBR2 (2) e17:TGFbeta3: TBR2 (2) e18:TGFbeta2: TBR2 (2): TGFbetaR-III (2) e19:TGFbeta1: TBR2 (2): TGFbetaR-III (2) e2: e20:TGFbeta1: TBR2 (2): endoglin e21:TGFbeta3: TBR2 (2): endoglin e22:TGFbeta: TBR2 (2): Tbr-1(2) {p}: SMAD e23:TGFbeta: TBR2 (2): Tbr-1(2) {p} e24:TGFbeta: TBR2 (2): Tbr-1(2) {p}: SMAD {p} e25:SMAD {p} e26:SMAD {p}: Smad4: Smad4 e27:SMAD {p}: Smad4: Smad4 {nucleus} e28:TGFbeta: TBR2 (2): Tbr-1(2) {p}: phosphosphotidyl inositol-3-phosphate: SARA: SMAD2 e29:TGFbeta: TBR2 (2): Tbr-1(2) {p}: phosphosphotidyl inositol-3-phosphate: SARA: SMAD2 {p} e3: e30:SMAD2 {p}: Smad4: Smad4 e31:SMAD2 {p} e32:SMAD2 {p}: Smad4: Smad4 (nucleus) e33:TGFbeta: TBR2 (2): Tbr-1(2) {p}: SMAD3 e34:TGFbeta: TBR2 (2): Tbr-1(2) {p}: SMAD3 {p} e35:SMAD3 {p} e36:SMAD3 {p}: Smad4: Smad4 e37:SMAD3 {p}: Smad4: Smad4(nucleus) e38:activin: Type II receptor (2): Type I activin recptor (2) {p}: SMAD2 e39:activin: Type II receptor (2): Type I activin recptor (2) {p}: SMAD3 e4: e40:TGFbeta: TBR2 (2): Tbr-1(2) {p}: SMAD1 e41:Type II receptor (2) e42:activin: Type II receptor (2) e43:Type I activin recptor (2) e44:activin: Type II receptor (2): Type I activin recptor (2) e45:TGFbeta: TBR2 (2): Tbr-1(2) {p}: SMAD1 {p} e46:SMAD1 {p} e47:BMP2: Type II receptor (2) e48:Type I receptor (2) e49:BMP2: Type II receptor (2): Type I receptor (2) e5:TGFbeta: TBR2 (2): Tbr-1(2) e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TBR2 e60: e61: e62: e63:BMP2: Type II receptor (2): Type I receptor (2) {p} : SMAD1 e64:BMP2: Type II receptor (2): Type I receptor (2) {p} e65:activin: Type II receptor (2): Type I activin recptor (2) {p} e66:BMP2: Type II receptor (2): Type I receptor (2) {p} : SMAD1 {p} e67:SMAD1 {p}: Smad4: Smad4 e68:SMAD1 {p}: Smad4: Smad4 (nucleus) e69:Smad4 e7: e70:phosphosphotidyl inositol-3-phosphate e71:phosphosphotidyl inositol-3-phosphate: SARA e72:TGFbeta: TBR2 (2): Tbr-1(2) {p}: phosphosphotidyl inositol-3-phosphate: SARA e73:SMAD2 {p}: Smad4: Smad4 (nuclus): FAST1 e74:FAST1 e75:SMAD3 {p}: Smad4: Smad4(nucleus): c-Jun e76:SMAD3 {p}: Smad4: Smad4(nucleus): c-Fos e77:CBP:p300 e78:CBP: p300: SMAD1 {p}: Smad4: Smad4 (nucleus) e79:CBP: p300: SMAD3 {p}: Smad4: Smad4(nucleus) e8: e80:CBP: p300: SMAD2 {p}: Smad4: Smad4 (nucleus) e81:CBP: p300: SMAD {p}: Smad4: Smad4 {nucleus} e82:CBP: p300: E1A e83:EGF: EGFR e84:IFN gamma: IFNgamma receptor e85:IFNgamma receptor e86:HGF receptor e87:HGF: HGF receptor e88:MSG1 e89:SMAD {p}: Smad4: Smad4 {nucleus}: MSG1 e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p7 p8 p9
Model Detail
552.0, 1204.0
32.0, 32.0

SMAD7

--

G010646

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p48 p62 p63

--

true true true true

csml-variable:Double

m93579

10

false

infinite

0

unit false false false
TRANSFACG010646

--

Go back
713.0, 1201.0
30.0, 30.0

SMAD6

--

G010667

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p47

--

true true true true

csml-variable:Double

m93598

10

false

infinite

0

unit false false false
TRANSFACG010667

--

Go back
775.0, 1059.0
26.0, 26.0

c-Jun

--

MO000000049

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
1090.0, 1118.0
28.0, 28.0

EGF

--

MO000000071

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
InterProIPR000033
TRANSPATHMO000000071

--

Go back
846.0, 1002.0
28.0, 28.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58 p59

true true true true

csml-variable:Double

m86

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
951.0, 1167.0
33.0, 33.0

EGFR

--

MO000000108

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m96

10

false

infinite

0

unit false false false
TRANSPATHMO000000108

--

Go back
707.0, 1107.0
26.0, 26.0

c-Fos

--

MO000000279

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m221

10

false

infinite

0

unit false false false
InterProIPR002114
TRANSPATHMO000000279

--

Go back
167.0, 531.0
26.0, 26.0

endoglin

--

MO000004387

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12

true true true true

csml-variable:Double

m501

10

false

infinite

0

unit false false false
InterProIPR001507
TRANSPATHMO000004387

--

Go back
361.0, 61.0
30.0, 30.0

TGFbeta2

--

MO000013604

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m1399

10

false

infinite

0

unit false false false
InterProIPR002400
TRANSPATHMO000013604

--

Go back
507.0, 1443.0
26.0, 26.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
497.0, 21.0
29.5, 29.5

TGFbeta

--

MO000016808

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m1746

10

false

infinite

0

unit false false false
TRANSPATHMO000016808

--

Go back
85.0, 629.0
30.0, 30.0

activin

--

MO000016809

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m1747

10

false

infinite

0

unit false false false
TRANSPATHMO000016809

--

Go back
565.0, 253.0
29.0, 29.0

Smads

--

MO000016824

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m1761

10

false

infinite

0

unit false false false
TRANSPATHMO000016824

--

Go back
413.0, 41.0
30.0, 30.0

TGFbeta1

--

MO000017443

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m2269

10

false

infinite

0

unit false false false
InterProIPR002400
TRANSPATHMO000017443

--

Go back
274.0, 174.0
28.0, 28.0

ALK-5 (2)

--

MO000017445

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m2271

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017445

--

Go back
506.0, 358.0
27.0, 27.0

Smad3

--

MO000017450

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p29

true true true true

csml-variable:Double

m2276

10

false

infinite

0

unit false false false
TRANSPATHMO000017450

--

Go back
544.0, 540.0
31.0, 31.0

Smad4: Smad4

--

MO000017458

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m2280

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000017458

--

Go back
458.0, 306.0
28.0, 28.0

Smad2

--

MO000017658

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p30 p61

true true true true

csml-variable:Double

m2422

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000017658

--

Go back
882.0, 162.0
28.0, 28.0

SARA

--

MO000017659

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m2423

10

false

infinite

0

unit false false false
InterProIPR000306
TRANSPATHMO000017659

--

Go back
162.0, 174.0
28.0, 28.0

ALK-1 (2)

--

MO000017720

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m2477

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017720

--

Go back
1081.0, 793.0
30.0, 30.0

BMP2

--

MO000017729

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m2486

10

false

infinite

0

unit false false false
InterProIPR002405
TRANSPATHMO000017729

--

Go back
165.0, 329.0
30.0, 30.0

TGFbetaR-III (2)

--

MO000017733

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p9 p10

true true true true

csml-variable:Double

m2490

10

false

infinite

0

unit false false false
InterProIPR001507
TRANSPATHMO000017733

--

Go back
885.0, 605.0
29.0, 29.0

Smad1

--

MO000017762

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31 p38 p58 p59

true true true true

csml-variable:Double

m2519

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000017762

--

Go back
1089.0, 1221.0
30.0, 30.0

HGF

--

MO000017768

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m2525

10

false

infinite

0

unit false false false
InterProIPR009003
TRANSPATHMO000017768

--

Go back
418.0, 1238.0
28.0, 28.0

E1A

--

MO000018970

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m3581

10

false

infinite

0

unit false false false
TRANSPATHMO000018970

--

Go back
310.0, 70.0
28.0, 28.0

TGFbeta3

--

MO000019248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m3831

10

false

infinite

0

unit false false false
InterProIPR002400
TRANSPATHMO000019248

--

Go back
561.0, 177.0
30.0, 30.0

Tbr-1

--

MO000118339

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m87297

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000118339

--

Go back
141.75, 163.9969080091176
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
150.0, 183.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
500.375, 177.5
23.25, 45.0

TGFbeta: TBR2 (2)

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
163.875, 221.5
32.25, 45.0

TGFbeta: TBR2 (2): ALK-1(2)

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
227.875, 165.5
32.25, 45.0

TGFbeta: TBR2 (2): ALK-5(2)

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
163.875, 277.5
32.25, 45.0

TGFbeta3: TBR2 (2): TGFbetaR-III (2)

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
411.875, 169.5
32.25, 45.0

TGFbeta1: TBR2 (2)

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
359.875, 169.5
32.25, 45.0

TGFbeta2: TBR2 (2)

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p9

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
310.875, 169.5
32.25, 45.0

TGFbeta3: TBR2 (2)

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
161.875, 367.5
28.998761240594607, 40.463387777573864

TGFbeta2: TBR2 (2): TGFbetaR-III (2)

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
159.875, 416.5
33.07070104606349, 46.14516425032115

TGFbeta1: TBR2 (2): TGFbetaR-III (2)

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
141.75, 163.9969080091176
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
159.875, 473.5
32.25, 45.0

TGFbeta1: TBR2 (2): endoglin

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
163.875, 565.5
32.25, 45.0

TGFbeta3: TBR2 (2): endoglin

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
733.875, 146.5
37.20577170122959, 51.91503028078546

TGFbeta: TBR2 (2): Tbr-1(2) {p}: SMAD

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
663.875, 157.5
38.00279867865663, 53.027160946962745

TGFbeta: TBR2 (2): Tbr-1(2) {p}

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
793.875, 134.5
36.10887318774087, 50.38447421545238

TGFbeta: TBR2 (2): Tbr-1(2) {p}: SMAD {p}

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
626.5, 464.125
42.760000000000005, 32.07

SMAD {p}

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
535.875, 741.5
32.25, 45.0

SMAD {p}: Smad4: Smad4

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
423.875, 921.5
32.25, 45.0

SMAD {p}: Smad4: Smad4 {nucleus}

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
951.875, 297.5
32.25, 45.0

TGFbeta: TBR2 (2): Tbr-1(2) {p}: phosphosphotidyl inositol-3-phosphate: SARA: SMAD2

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
952.875, 353.5
37.797623417140755, 52.740869884382455

TGFbeta: TBR2 (2): Tbr-1(2) {p}: phosphosphotidyl inositol-3-phosphate: SARA: SMAD2 {p}

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
158.87518862352908, 181.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
603.875, 733.5
32.25, 45.0

SMAD2 {p}: Smad4: Smad4

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
706.5, 431.125
34.440000000000005, 25.83

SMAD2 {p}

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
487.875, 985.5
32.25, 45.0

SMAD2 {p}: Smad4: Smad4 (nucleus)

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
951.875, 481.5
32.25, 45.0

TGFbeta: TBR2 (2): Tbr-1(2) {p}: SMAD3

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
951.875, 533.5
32.25, 45.0

TGFbeta: TBR2 (2): Tbr-1(2) {p}: SMAD3 {p}

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
754.5, 555.125
34.440000000000005, 25.83

SMAD3 {p}

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
651.875, 789.5
32.25, 45.0

SMAD3 {p}: Smad4: Smad4

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
631.875, 997.5
32.25, 45.0

SMAD3 {p}: Smad4: Smad4(nucleus)

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
163.875, 897.5
32.25, 45.0

activin: Type II receptor (2): Type I activin recptor (2) {p}: SMAD2

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
159.875, 949.5
32.25, 45.0

activin: Type II receptor (2): Type I activin recptor (2) {p}: SMAD3

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
190.5567875770579, 211.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
946.875, 587.5
41.33295100018352, 57.67388511653514

TGFbeta: TBR2 (2): Tbr-1(2) {p}: SMAD1

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
166.375, 622.5
27.307996485061512, 42.012302284710024

Type II receptor (2)

--

e41

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p32 p36

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
168.375, 677.5
23.25, 45.0

activin: Type II receptor (2)

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
168.375, 738.5
22.464411247803167, 34.56063268892795

Type I activin recptor (2)

--

e43

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p33

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
165.375, 780.5
29.912565905096656, 46.019332161687146

activin: Type II receptor (2): Type I activin recptor (2)

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
951.875, 657.5
32.25, 45.0

TGFbeta: TBR2 (2): Tbr-1(2) {p}: SMAD1 {p}

--

e45

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
818.5, 799.125
34.12, 25.59

SMAD1 {p}

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
951.875, 725.5
32.25, 45.0

BMP2: Type II receptor (2)

--

e47

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
958.375, 791.5
27.148066783831283, 41.76625659050967

Type I receptor (2)

--

e48

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p37

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
950.875, 847.5
41.51445219306295, 57.927142594971556

BMP2: Type II receptor (2): Type I receptor (2)

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
604.5, 162.0
39.0, 60.0

TGFbeta: TBR2 (2): Tbr-1(2)

--

e5

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
307.0, 870.0
508.82154477887383, 461.44523707134414

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
361.9565169407349, 880.9355812827336
297.5232124032895, 447.2323447590849

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
313.63268307905423, 876.1589200019788
495.55617862076565, 449.12739706738614

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
314.58020923320487, 877.1064461561296
493.6611263124642, 447.2323447590849

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
307.0, 870.0
508.82154477887383, 461.44523707134414

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
307.0, 870.0
508.82154477887383, 461.44523707134414

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
314.58020923320487, 877.1064461561296
493.6611263124642, 447.2323447590849

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
678.4302524270363, 1059.5052308301206
31.788374395733378, 28.776844189821837

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
595.0479508617834, 1192.1588924112048
90.01498464430728, 81.48724925695197

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
307.0, 870.0
508.82154477887383, 461.44523707134414

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
461.0, 173.0
30.0, 30.0

TBR2

--

e6

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p6 p7 p8

true true true true

csml-variable:Double

m6

10

false

infinite

0

unit false false false
Affymetrix231776_at
EnsemblENSG00000163508
HGNCEOMES
InterProIPR008967
OMIM604615
ProteomeHumanPSD/EOMES
RefSeqNM_005442
TRANSFACT04395
TRANSPATHMO000028249
UnigeneHs.147279
UniProtO95936

--

Go back
426.9263751626087, 1075.0624504011216
16.113630688421328, 7.758414775906573

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
426.38829542297594, 1051.925021596916
55.15317331235113, 99.27571196223207

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
449.5257242271822, 1116.4945903528396
8.609275834123093, 8.6092758341231

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
952.875, 981.5
37.93177647274729, 52.928060194531106

BMP2: Type II receptor (2): Type I receptor (2) {p} : SMAD1

--

e63

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
951.875, 921.5
32.25, 45.0

BMP2: Type II receptor (2): Type I receptor (2) {p}

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
162.5, 842.0
29.908240044044774, 41.732427968434564

activin: Type II receptor (2): Type I activin recptor (2) {p}

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
955.875, 1049.5
32.25, 45.0

BMP2: Type II receptor (2): Type I receptor (2) {p} : SMAD1 {p}

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
707.875, 717.5
32.25, 45.0

SMAD1 {p}: Smad4: Smad4

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
743.875, 1161.5
32.25, 45.0

SMAD1 {p}: Smad4: Smad4 (nucleus)

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
486.5, 607.125
34.919999999999995, 26.189999999999998

Smad4

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p45

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
153.0, 169.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
945.5, 203.25
45.0, 25.5

phosphosphotidyl inositol-3-phosphate

--

e70

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p46

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
955.875, 241.5
29.606395668930077, 41.311249770600114

phosphosphotidyl inositol-3-phosphate: SARA

--

e71

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
951.875, 421.5
32.25, 45.0

TGFbeta: TBR2 (2): Tbr-1(2) {p}: phosphosphotidyl inositol-3-phosphate: SARA

--

e72

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22 p25

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
583.875, 1009.5
32.25, 45.0

SMAD2 {p}: Smad4: Smad4 (nuclus): FAST1

--

e73

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p49

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
602.0, 938.0
36.0, 36.0

FAST1

--

e74

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
Affymetrix131293_at
EnsemblENSMUSG00000033837
MGDFoxh1
ProteomeHumanPSD/Foxh1
RefSeqNM_007989
TRANSFACT04100
TRANSPATHMO000028003
UnigeneMm.42011
UniProtQ9R241

--

Go back
767.875, 1097.5
32.25, 45.0

SMAD3 {p}: Smad4: Smad4(nucleus): c-Jun

--

e75

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p50

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
583.875, 1117.5
32.25, 45.0

SMAD3 {p}: Smad4: Smad4(nucleus): c-Fos

--

e76

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p51

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
339.0, 1067.0
34.0, 34.0

CBP:p300

--

e77

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m78

10

false

infinite

0

unit false false false
TRANSPATHMO000103331

--

Go back
491.875, 1233.5
32.25, 45.0

CBP: p300: SMAD1 {p}: Smad4: Smad4 (nucleus)

--

e78

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p55

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
531.875, 1129.5
32.25, 45.0

CBP: p300: SMAD3 {p}: Smad4: Smad4(nucleus)

--

e79

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p54

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
156.0, 190.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
491.875, 1057.5
32.25, 45.0

CBP: p300: SMAD2 {p}: Smad4: Smad4 (nucleus)

--

e80

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p53

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
367.875, 993.5
32.25, 45.0

CBP: p300: SMAD {p}: Smad4: Smad4 {nucleus}

--

e81

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p52

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
422.875, 1185.5
26.221003853918152, 36.587447238025334

CBP: p300: E1A

--

e82

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
956.375, 1109.5
23.25, 45.0

EGF: EGFR

--

e83

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
560.375, 1345.5
23.25, 45.0

IFN gamma: IFNgamma receptor

--

e84

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
445.375, 1357.5
29.25, 45.0

IFNgamma receptor

--

e85

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p64

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
955.375, 1272.5
25.02328646748682, 38.49736379613357

HGF receptor

--

e86

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p60

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
952.375, 1213.5
23.25, 45.0

HGF: HGF receptor

--

e87

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
536.5, 902.125
31.51237673576172, 19.432632320386396

MSG1

--

e88

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p65

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
486.875, 942.5
25.684391631492016, 35.83868599743072

SMAD {p}: Smad4: Smad4 {nucleus}: MSG1

--

e89

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p65

--

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
164.0, 211.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
500.0, 104.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c5 : 1

m1746*m6*0.1

nodelay

--

true

0

false

PMID: 10611754, 9759503, 9393997, 9561843 Receptor complexes are heterotetrameric, consisting of two ¡Ætype II' receptors (75?85 kDa), which bind ligand, and two signal transducing ¡Ætype I' receptors (50?60 kDa) which, in most instances, cannot bind ligand directly and thus are considered to act downstream of the type II receptor. PMID: 10611754 Signals from all three isoforms of TGF-beta appear to be mediated by a single type II receptor called TBR-II and one type I receptor referred to either as TBR-I or ALK-5 (activin receptor-like kinase).

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252.0, 372.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c30 : 1
stoichiometry:c28 : 1

m15*m2490*0.1

nodelay

--

true

0

false

PMID: 10611754 Betaglycan, formerly called the ¡Ætype III receptor', binds all isoforms of TGF-beta, but may play a selective role in facilitating interaction of TGF-beta2 with TBR-II, since this isoform binds to the type II receptor with significantly lower affinity than that of TGF-beta1 and TGF-beta3.

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239.0, 483.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c35 : 1

m15*m501*0.1

nodelay

--

true

0

false

PMID: 10611754 Unlike betaglycan, endoglin binds TGF-beta1 and TGF-beta3 selectively.

Go back
247.0, 531.0
25.0, 25.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c36 : 1

m17*m501*0.1

nodelay

--

true

0

false

PMID: 10611754 Unlike betaglycan, endoglin binds TGF-beta1 and TGF-beta3 selectively.

Go back
671.0, 83.0
25.0, 25.0

p13

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 10611754 This model for receptor activation involves potentiation of the kinase activity of the type I receptor by phosphorylation of several residues in a glycine-serine-rich juxtamembrane domain (GS domain) by the type II receptor kinase.

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655.0, 255.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m23*m1761*0.1

nodelay

--

true

0

false

PMID: 10611754 receptor-activated Smads bind to and are phosphorylated on two C-terminal serine residues in their MH2 domain by the type I receptor kinase.

Go back
800.0, 72.0
24.0, 24.0

p15

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 10611754 receptor-activated Smads bind to and are phosphorylated on two C-terminal serine residues in their MH2 domain by the type I receptor kinase.

Go back
595.0, 523.0
25.0, 25.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c49 : 1

m25*m2280*0.1

nodelay

--

true

0

false

PMID: 10611754 the phosphorylated, pathway-specific Smads then hetero-oligomerize in the cytoplasm with the common mediator, Smad4.

Go back
706.0, 378.0
27.0, 27.0

p17

p17

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c48 : 1
stoichiometry:c45 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 10611754 the phosphorylated, pathway-specific Smads then hetero-oligomerize in the cytoplasm with the common mediator, Smad4.

Go back
518.0, 846.0
27.0, 27.0

p18

p18

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 10611754 the heteromeric Smad4-containing complex is then translocated to the nucleus where it mediates transcriptional activation of the target gene.

Go back
868.0, 308.0
24.0, 24.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c52 : 1
stoichiometry:c125 : 1
stoichiometry:c54 : 1

m2422*m23*m71*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors. PMID: 10611754 The FYVE domain of SARA is predicted to interact with phosphosphotidyl inositol-3-phosphate in the cell membrane while an adjacent Smad binding domain recruits Smad2/3 from the cytoplasmic reservoir; the C-terminal domain anchors the Smad-SARA complex to the receptor complex.

Go back
613.0, 81.0
22.0, 22.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c6 : 1
stoichiometry:c4 : 1

m11*m87297*0.1

nodelay

--

true

0

false

PMID: 10611754 The assembly of the heteromeric complex is initiated by ligand binding and stabilized by interactions between the cytoplasmic domains of the type II and type I receptors. PMID: 10611754 Signals from all three isoforms of TGF-beta appear to be mediated by a single type II receptor called TBR-II and one type I receptor referred to either as TBR-I or ALK-5 (activin receptor-like kinase).

Go back
867.0, 359.0
25.0, 25.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c126 : 1
stoichiometry:c67 : 1

m23*m2276*m71*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors. PMID: 10611754 The FYVE domain of SARA is predicted to interact with phosphosphotidyl inositol-3-phosphate in the cell membrane while an adjacent Smad binding domain recruits Smad2/3 from the cytoplasmic reservoir; the C-terminal domain anchors the Smad-SARA complex to the receptor complex.

Go back
1034.0, 366.0
27.0, 27.0

p21

p21

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors.

Go back
863.0, 431.0
25.0, 25.0

p22

p22

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c61 : 1
stoichiometry:c127 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors.

Go back
646.0, 554.0
27.0, 27.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m2280*m31*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors.

Go back
590.0, 846.0
27.0, 27.0

p24

p24

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c178 : 1
stoichiometry:c66 : 1

m30*m89*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors. PMID: 10611754 Examples are the activating phosphorylation and nuclear translocation of Smad2 following treatment of cells with HGF [54] or activation of the SAPK/JNK pathway.

Go back
859.0, 483.0
25.0, 25.0

p25

p25

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c69 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors.

Go back
1026.0, 542.0
27.0, 27.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c70 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors.

Go back
687.0, 599.0
25.0, 25.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m35*m2280*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors.

Go back
642.0, 866.0
27.0, 27.0

p28

p28

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors.

Go back
256.0, 960.0
23.0, 23.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c109 : 1
stoichiometry:c89 : 1

m2276*m65*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors.

Go back
243.0, 231.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c7 : 1
stoichiometry:c9 : 1

m2477*m11*0.1

nodelay

--

true

0

false

PMID: 10611754, 10187774 Another type I receptor, ALK-1, expressed on endothelial cells and mutated in the autosomal dominant disorder hereditary hemorrhagic telangiectasia (HHT), can also complex with ligand-bound TBR-II, but its role in signaling is presently not understood.

Go back
235.0, 907.0
25.0, 25.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c108 : 1
stoichiometry:c88 : 1

m2422*m65*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors.

Go back
851.0, 535.0
25.0, 25.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m23*m2519*0.1

nodelay

--

true

0

false

PMID: 10611754, 9788633 Smad1 is phosphorylated and partners with Smad4 following treatment of human breast cancer cells with either BMP-2 or TGF-beta.

Go back
88.0, 688.0
23.0, 23.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m1747*m41*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors.

Go back
83.0, 743.0
25.0, 25.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c90 : 1

m42*m43*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors.

Go back
1019.0, 667.0
25.0, 25.0

p34

p34

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 10611754, 9788633 Smad1 is phosphorylated and partners with Smad4 following treatment of human breast cancer cells with either BMP-2 or TGF-beta.

Go back
854.0, 666.0
27.0, 27.0

p35

p35

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c113 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 10611754, 9788633 Smad1 is phosphorylated and partners with Smad4 following treatment of human breast cancer cells with either BMP-2 or TGF-beta.

Go back
1027.0, 735.0
25.0, 25.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m41*m2486*0.1

nodelay

--

true

0

false

PMID: 10611754, 9788633 Smad1 is phosphorylated and partners with Smad4 following treatment of human breast cancer cells with either BMP-2 or TGF-beta.

Go back
1011.0, 863.0
25.0, 25.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m47*m48*0.1

nodelay

--

true

0

false

PMID: 10611754, 9788633 Smad1 is phosphorylated and partners with Smad4 following treatment of human breast cancer cells with either BMP-2 or TGF-beta.

Go back
1099.0, 995.0
25.0, 25.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c107 : 1

m2519*m64*0.1

nodelay

--

true

0

false

PMID: 10611754, 9788633 Smad1 is phosphorylated and partners with Smad4 following treatment of human breast cancer cells with either BMP-2 or TGF-beta.

Go back
1031.0, 931.0
25.0, 25.0

p39

p39

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 10611754, 9788633 Smad1 is phosphorylated and partners with Smad4 following treatment of human breast cancer cells with either BMP-2 or TGF-beta.

Go back
260.0, 116.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c10 : 1
stoichiometry:c12 : 1

m2271*m11*0.1

nodelay

--

true

0

false

PMID: 10611754 Signals from all three isoforms of TGF-beta appear to be mediated by a single type II receptor called TBR-II and one type I receptor referred to either as TBR-I or ALK-5 (activin receptor-like kinase).

Go back
84.0, 848.0
23.0, 23.0

p40

p40

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 10611754, 9311995, 8752209 Of the five receptor-activated Smads identified thus far, Smad2 and 3 have been shown to mediate signals from TGF-beta and activin receptors.

Go back
823.0, 1059.0
25.0, 25.0

p41

p41

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c111 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 10611754, 9788633 Smad1 is phosphorylated and partners with Smad4 following treatment of human breast cancer cells with either BMP-2 or TGF-beta.

Go back
1035.0, 1059.0
25.0, 25.0

p42

p42

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c112 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 10611754, 9788633 Smad1 is phosphorylated and partners with Smad4 following treatment of human breast cancer cells with either BMP-2 or TGF-beta.

Go back
725.0, 669.0
22.0, 22.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m2280*m46*0.1

nodelay

--

true

0

false

PMID: 10611754, 9788633 Smad1 is phosphorylated and partners with Smad4 following treatment of human breast cancer cells with either BMP-2 or TGF-beta.

Go back
691.0, 899.0
25.0, 25.0

p44

p44

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c171 : 1
stoichiometry:c174 : 1
stoichiometry:c119 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 10611754, 9788633 Smad1 is phosphorylated and partners with Smad4 following treatment of human breast cancer cells with either BMP-2 or TGF-beta. PMID: 10611754 Treatment of cells with EGF or hepatocyte growth factor (HGF) results in phosphorylation of Smad1 on these sites by the Erk subfamily of MAP kinases, and in retention of the linker-region phosphorylated Smad1 in the cytoplasm, blocking the nuclear translocation and transcriptional activating activity of Smad1/Smad4 complexes.

Go back
491.0, 543.0
26.0, 26.0

p45

p45

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 10611754, 9214508, 9670020 Determination of the tertiary structure of the C-terminal domain of Smad4 shows that it associates as a homotrimer [25], and data now suggest that hetero-oligomeric Smads are also trimeric.

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886.0, 234.0
24.0, 24.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m2423*m70*0.1

nodelay

--

true

0

false

PMID: 19611754 he FYVE domain of SARA is predicted to interact with phosphosphotidyl inositol-3-phosphate in the cell membrane while an adjacent Smad binding domain recruits Smad2/3 from the cytoplasmic reservoir.

Go back
668.0, 1204.0
23.0, 23.0

p47

p47

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c130 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 10611754 The mRNAs for Smad6 and Smad7 are rapidly induced by treatment of cells with TGF-beta suggesting that anti-Smads are direct effectors of a ligand-induced signal to suppress a response.

Go back
624.0, 1208.0
23.0, 23.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c131 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 10611754 The mRNAs for Smad6 and Smad7 are rapidly induced by treatment of cells with TGF-beta suggesting that anti-Smads are direct effectors of a ligand-induced signal to suppress a response.

Go back
535.0, 1047.0
25.0, 25.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c133 : 1
stoichiometry:c132 : 1

m32*m74*0.1

nodelay

--

true

0

false

PMID: 10611754 the MH2 domain of Smad2 interacts with the C-terminal domain (Smad-interaction domain, SID) of FAST-1 directly, while the binding of Smad4 is assumed to be dependent on its association with activated Smad2 and possibly also on its ability to stabilize the DNA complex through its MH1 domain.

Go back
244.0, 288.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c26 : 1
stoichiometry:c14 : 1

m2490*m17*0.1

nodelay

--

true

0

false

PMID: 10611754 Betaglycan, formerly called the ¡Ætype III receptor', binds all isoforms of TGF-beta, but may play a selective role in facilitating interaction of TGF-beta2 with TBR-II, since this isoform binds to the type II receptor with significantly lower affinity than that of TGF-beta1 and TGF-beta3.

Go back
704.0, 1064.0
23.0, 23.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m37*m75*0.1

nodelay

--

true

0

false

PMID: 10611754, 9732876 Smad3 can interact directly with c-Jun and c-Fos through its MH1 and MH2 domains, respectively leading to the suggestion that AP-1 DNA binding sites can be activated either by direct binding of Smad3 and Smad4 to the DNA element itself or by interaction of the heteromeric Smad3/Smad4 complex and the AP-1 transcription factor complex, in such a manner as to provide additional stability to the complex.

Go back
639.0, 1099.0
25.0, 25.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1

m37*m221*0.1

nodelay

--

true

0

false

PMID: 10611754, 9732876 Smad3 can interact directly with c-Jun and c-Fos through its MH1 and MH2 domains, respectively leading to the suggestion that AP-1 DNA binding sites can be activated either by direct binding of Smad3 and Smad4 to the DNA element itself or by interaction of the heteromeric Smad3/Smad4 complex and the AP-1 transcription factor complex, in such a manner as to provide additional stability to the complex.

Go back
432.0, 1016.0
23.0, 23.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c144 : 1
stoichiometry:c155 : 1
stoichiometry:c148 : 1

m27*m78*0.1

nodelay

--

true

0

false

PMID: 10611754 These proteins have now been shown to also interact with Smad proteins in the regulation of transcription. PMID: 10611754, 9689110 The essential nature of this interaction is demonstrated by the fact that disruption of the Smad-CBP/p300 interaction by the adenoviral transforming protein E1A, which binds the coactivators, blocks nearly all Smad-stimulated transcriptional responses in cells.

Go back
408.0, 1072.0
23.0, 23.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c145 : 1
stoichiometry:c156 : 1
stoichiometry:c149 : 1

m32*m78*0.1

nodelay

--

true

0

false

PMID: 10611754, 9679060, 9865696 Depending on the system and the cell type, ligand-activated Smad1, Smad2, and Smad3, as well as Smad4 have all been shown to be capable of binding to CBP/p300. PMID: 10611754, 9689110 The essential nature of this interaction is demonstrated by the fact that disruption of the Smad-CBP/p300 interaction by the adenoviral transforming protein E1A, which binds the coactivators, blocks nearly all Smad-stimulated transcriptional responses in cells.

Go back
475.0, 1127.0
25.0, 25.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c146 : 1
stoichiometry:c157 : 1
stoichiometry:c150 : 1

m37*m78*0.1

nodelay

--

true

0

false

PMID: 10611754, 9679060, 9865696 Depending on the system and the cell type, ligand-activated Smad1, Smad2, and Smad3, as well as Smad4 have all been shown to be capable of binding to CBP/p300. PMID: 10611754, 9689110 The essential nature of this interaction is demonstrated by the fact that disruption of the Smad-CBP/p300 interaction by the adenoviral transforming protein E1A, which binds the coactivators, blocks nearly all Smad-stimulated transcriptional responses in cells.

Go back
496.0, 1172.0
23.0, 23.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c147 : 1
stoichiometry:c158 : 1
stoichiometry:c151 : 1

m68*m78*0.1

nodelay

--

true

0

false

PMID: 10611754, 9679060, 9865696 Depending on the system and the cell type, ligand-activated Smad1, Smad2, and Smad3, as well as Smad4 have all been shown to be capable of binding to CBP/p300. PMID: 10611754, 9689110 The essential nature of this interaction is demonstrated by the fact that disruption of the Smad-CBP/p300 interaction by the adenoviral transforming protein E1A, which binds the coactivators, blocks nearly all Smad-stimulated transcriptional responses in cells.

Go back
371.0, 1187.0
25.0, 25.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m78*m3581*0.1

nodelay

--

true

0

false

PMID: 10611754, 9689110 The essential nature of this interaction is demonstrated by the fact that disruption of the Smad-CBP/p300 interaction by the adenoviral transforming protein E1A, which binds the coactivators, blocks nearly all Smad-stimulated transcriptional responses in cells.

Go back
1028.0, 1120.0
23.0, 23.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m96*m84*0.1

nodelay

--

true

0

false

PMID: 10611754 Treatment of cells with EGF or hepatocyte growth factor (HGF) results in phosphorylation of Smad1 on these sites by the Erk subfamily of MAP kinases, and in retention of the linker-region phosphorylated Smad1 in the cytoplasm, blocking the nuclear translocation and transcriptional activating activity of Smad1/Smad4 complexes.

Go back
904.0, 936.0
23.0, 23.0

p58

p58

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c168 : 1
stoichiometry:c172 : 1
stoichiometry:c170 : 1

m2519*m86*m85*0.1

nodelay

--

true

0

false

PMID: 10611754 Treatment of cells with EGF or hepatocyte growth factor (HGF) results in phosphorylation of Smad1 on these sites by the Erk subfamily of MAP kinases, and in retention of the linker-region phosphorylated Smad1 in the cytoplasm, blocking the nuclear translocation and transcriptional activating activity of Smad1/Smad4 complexes.

Go back
851.0, 935.0
25.0, 25.0

p59

p59

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c173 : 1
stoichiometry:c169 : 1

m2519*m86*m89*0.1

nodelay

--

true

0

false

PMID: 10611754 Treatment of cells with EGF or hepatocyte growth factor (HGF) results in phosphorylation of Smad1 on these sites by the Erk subfamily of MAP kinases, and in retention of the linker-region phosphorylated Smad1 in the cytoplasm, blocking the nuclear translocation and transcriptional activating activity of Smad1/Smad4 complexes.

Go back
416.0, 104.0
23.0, 23.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m2269*m6*0.1

nodelay

--

true

0

false

PMID: 10611754 Betaglycan, formerly called the ¡Ætype III receptor', binds all isoforms of TGF-beta, but may play a selective role in facilitating interaction of TGF-beta2 with TBR-II, since this isoform binds to the type II receptor with significantly lower affinity than that of TGF-beta1 and TGF-beta3.

Go back
1027.0, 1223.0
25.0, 25.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c164 : 1

m88*m2525*0.1

nodelay

--

true

0

false

PMID: 10611754 Treatment of cells with EGF or hepatocyte growth factor (HGF) results in phosphorylation of Smad1 on these sites by the Erk subfamily of MAP kinases, and in retention of the linker-region phosphorylated Smad1 in the cytoplasm, blocking the nuclear translocation and transcriptional activating activity of Smad1/Smad4 complexes.

Go back
458.0, 430.0
27.0, 27.0

p61

p61

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c177 : 1
stoichiometry:c176 : 1

m2422*m89*0.1

nodelay

--

true

0

false

PMID: 10611754 Examples are the activating phosphorylation and nuclear translocation of Smad2 following treatment of cells with HGF [54] or activation of the SAPK/JNK pathway.

Go back
597.0, 1257.0
23.0, 23.0

p62

p62

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c179 : 1

m85*0.1

nodelay

--

true

0

false

PMID: 10611754, 9712726, 10067896 Smad7 is also an important focal point of disparate signaling pathways as evidenced by its induction by EGF [35] and interferon.

Go back
552.0, 1260.0
23.0, 23.0

p63

p63

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c180 : 1

m87*0.1

nodelay

--

true

0

false

PMID: 10611754, 9712726, 10067896 Smad7 is also an important focal point of disparate signaling pathways as evidenced by its induction by EGF [35] and interferon.

Go back
506.0, 1358.0
27.0, 27.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c184 : 1
stoichiometry:c183 : 1

m1639*m90*0.1

nodelay

--

true

0

false

PMID: 10611754, 9712726, 10067896 Smad7 is also an important focal point of disparate signaling pathways as evidenced by its induction by EGF [35] and interferon.

Go back
490.0, 902.0
19.0, 19.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c187 : 1
stoichiometry:c188 : 1

m27*m91*0.1

nodelay

--

true

0

false

PMID: 10611754, 9707553 Another nuclear protein that strongly activates transcription without binding to DNA, MSG1, has been shown to interact functionally with the SAD domain in the middle linker region of Smad4 and to be required for activation of Smad4-dependent transcription in certain cells.

Go back
364.0, 112.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c23 : 1
stoichiometry:c20 : 1

m1399*m6*0.1

nodelay

--

true

0

false

PMID: 10611754 Betaglycan, formerly called the ¡Ætype III receptor', binds all isoforms of TGF-beta, but may play a selective role in facilitating interaction of TGF-beta2 with TBR-II, since this isoform binds to the type II receptor with significantly lower affinity than that of TGF-beta1 and TGF-beta3.

Go back
311.0, 119.0
25.0, 25.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c24 : 1
stoichiometry:c22 : 1

m3831*m6*0.1

nodelay

--

true

0

false

PMID: 10611754 Betaglycan, formerly called the ¡Ætype III receptor', binds all isoforms of TGF-beta, but may play a selective role in facilitating interaction of TGF-beta2 with TBR-II, since this isoform binds to the type II receptor with significantly lower affinity than that of TGF-beta1 and TGF-beta3.

Go back
248.0, 332.0
23.0, 23.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c29 : 1
stoichiometry:c27 : 1

m16*m2490*0.1

nodelay

--

true

0

false

PMID: 10611754 Betaglycan, formerly called the ¡Ætype III receptor', binds all isoforms of TGF-beta, but may play a selective role in facilitating interaction of TGF-beta2 with TBR-II, since this isoform binds to the type II receptor with significantly lower affinity than that of TGF-beta1 and TGF-beta3.

Go back
512.0, 51.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.03380162074893, 11.513187791849091

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.0, 771.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
986.0, 829.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.0, 876.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
908.0, 634.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
984.0, 951.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 895.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 944.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
999.0, 1008.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
192.0, 875.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
192.0, 881.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.99232831848497, 146.7479434607748

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
991.0, 1024.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
836.0, 833.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
996.0, 1072.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
840.9057722223812, 693.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
856.0, 1072.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
575.0, 567.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
748.8376739215317, 697.3715705307978

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.4567140814585, 691.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
705.9347299805391, 763.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
706.0, 924.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
258.2491077284276, 139.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.0, 577.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.0, 556.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
897.0, 190.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.3846153846154, 226.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
910.0, 249.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
898.7839864320407, 272.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.082916536019, 280.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
888.0, 444.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.884242329639, 48.000005004760794

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
636.167193776717, 27.503889846104357

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
279.20633098764773, 211.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
691.0, 1216.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
592.0, 1220.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
560.0, 1043.810265188326

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.5816675103376, 974.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
664.0, 1033.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
734.9930645847388, 1073.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
727.0, 1083.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
649.0, 1043.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
671.9464590424101, 1113.9240068653964

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.0926787693236, 1119.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
204.0, 300.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
441.0, 967.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.9619305082008, 1023.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.4, 1032.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.0, 1184.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
373.0, 1040.250312299017

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
373.0, 1084.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
373.0, 1091.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
373.0, 1095.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
407.8152001391701, 1020.7095750304435

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 1081.3929676735984

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
195.0, 310.9691115068547

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.0, 1142.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.0, 1195.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
360.0, 1101.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.42624082186455, 1217.87842755702

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
396.0, 1201.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.0, 1042.9954725508978

c155

c155

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
422.5229453222747, 1098.9656686939168

c156

c156

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
449.0, 1155.115015636333

c157

c157

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
449.0, 1188.0663442181535

c158

c158

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
984.0, 1145.7053735814004

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
428.0, 71.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1059.0, 1132.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
988.0, 1132.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
980.0, 1250.8646150223078

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1060.0, 1236.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
984.0, 1236.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
901.0, 634.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
865.8718523460146, 634.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
861.0, 967.9909451017955

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
872.0, 965.2044960296895

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.5689290811055, 832.8446454055273

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
439.4708276965784, 133.63413142072926

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.0886031430172, 831.8762871041653

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
719.0728851183895, 924.560737598658

c171

c171

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
921.1910383582268, 966.6941114440057

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
870.6189287334793, 967.5591806625425

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
716.5013427251669, 927.121423484767

c174

c174

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
472.0, 334.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
485.0, 444.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.2206834990064, 463.7960158034848

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
621.5320236747107, 878.7789890173317

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
586.2063309876478, 1242.0740528189224

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.0, 127.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.0, 1243.972366065959

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.4684821434008, 1136.0

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
520.0, 1393.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
533.0, 1369.5909734841225

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
475.0, 1375.0237707010415

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
565.632930407985, 1290.9749231406106

c185

c185

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
456.0, 920.7431017633522

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.0, 912.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.0, 921.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
376.0, 91.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
484.0, 134.15541752799933

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
376.0, 135.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
324.0, 98.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
325.0, 144.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.75304697609073, 135.2890974037333

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.5077698700194, 138.76285931216714

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
273.8596008605664, 213.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
268.39525010701436, 215.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
198.07934577905587, 350.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
199.77752501735145, 392.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
195.0, 344.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
524.0, 108.55906282333518

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
195.0, 351.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
264.005233980349, 215.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
193.0, 509.37014224437536

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
263.5163105547119, 215.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
193.0, 544.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
200.0, 496.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
203.01262840623676, 551.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
643.0, 114.76986272071801

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
683.1599680095968, 108.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
671.4310835055999, 211.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
624.0, 103.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.0, 268.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
679.0, 198.98459710700058

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.0, 102.59610682115043

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 96.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.9311843941235, 185.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
689.4144837152699, 218.8739593483353

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
621.6039472493969, 496.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
575.0, 543.9711254108329

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
666.0486997393298, 405.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
559.8836531203159, 548.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
512.0, 127.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.5944732131918, 787.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
461.9368211420091, 873.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.0, 197.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.0, 320.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.0, 320.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.0, 202.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
533.0, 372.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
984.0, 332.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
999.0, 380.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
894.6721522815722, 393.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
583.0, 110.19388070996636

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.0, 1027.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
749.0, 444.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.0, 558.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
670.6654081713672, 457.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
626.6377649323771, 581.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
607.2960811950677, 779.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
523.4646781863456, 873.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
888.0, 384.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
984.0, 516.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
884.0, 456.8235746377151

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
275.88368092595476, 202.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 556.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
890.8063839788744, 508.2039430457753

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
795.4658919698269, 505.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
718.8458558686448, 579.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
575.0, 562.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.2379198083759, 624.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
659.5201752525269, 835.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
649.4563983243081, 893.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.0, 211.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
873.6408884783128, 567.1234774575687

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
190.0, 198.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
876.0, 556.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
100.0, 659.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
117.52586312860231, 653.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
111.0, 700.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
114.65640235470275, 708.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
116.0, 756.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
255.79895164374855, 334.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.103309382893, 385.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
204.0, 920.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
200.0, 972.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
204.0, 244.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
108.0, 763.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
113.63874055461457, 814.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
107.0, 861.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 636.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 680.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
889.0, 680.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
695.7999606409683, 218.49401230376813

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
87.75512022075839, 4.1430198111199275

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1056.4774036933125, 765.8307845767519

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 748.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back