1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/10669111.csml convertedTime:2009.07.01.10:38

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The Lps locus: genetic regulation of host responses to bacteriallipopolysaccharide.
Authors Qureshi ST, Gros P, Malo D.
Affiliation Department of Medicine, McGill University, Montreal, Quebec, Canada.mc76@musica.mcgill.ca
Abstract Lipopolysaccharide (LPS), an abundant glycolipid of the outer membrane ofgram-negative bacteria, is able to provoke a generalized proinflammatoryresponse in the infected host. Genetic regulation of this trait has beenlocalized to the Lps locus on mouse chromosome 4. Several inbred mouse strains,including C3H/HeJ, C57BL/10ScNCr and C57BL/10ScCr, bear mutations at the Lpslocus (Lps(d)) that confer hyporesponsiveness to the immunostimulatoryproperties of LPS and susceptibility to overwhelming gram-negative bacterialinfection. The phenotypic expression of Lps(d) is pleiotropic, affecting severalcell types crucial to host defense, including the macrophage. By positionalcloning, Toll-like receptor 4 (Tlr4), a transmembrane protein with a cytoplasmicdomain that bears homology to the Interleukin-1 receptor, has been identified asthe gene encoded by Lps. Tlr4 is a member of a novel gene family thatparticipates in host defense against microbial infection in plants,invertebrates and mammals. Discovery of the molecular basis of the Lps mutationrepresents a significant advance in defining the fundamental mechanisms ofcellular activation by LPS.
PMID 10669111
Model Abstract

Entity

e1: e10: e11:LPS:LBP e12:sCD14 e13:mCD14 e14:LPS:LBP:mCD14 e15:LPS:LBP:sCD14 e16:TLR4 e17:MYD88 e18:LPS:LBP:CD14:TLR4 e19:SIIK e2: e20:SIIK{active} e21:TRAF6 e22:TRAF6{active} e23:NFKB:IKB e24:NFKB{active} e25:IKB e26:NFKB[active} e27:mRNA e28:LPS:LBP:CD14:TLR4:MYD88 e29:TOLL e3: e30:IL-1R e31:spatzle e32:IL-1 e33:TOLL:Spatzle e34:IL-1R:IL-1 e35:Dorsal e36:Dorsal e38:IL-1 e39:IL-6 e4: e40:IL-8 e41:B7.1 e5:LPS e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LBP e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p7 p8 p9
Model Detail
43.75, 133.9969080091176
792.4561480998934, 1150.646327041044

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
51.38525981003394, 151.5840043175252
768.1326785662795, 1080.546691685874

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
198.0, 72.0
43.85635359116023, 48.729281767955804

LPS:LBP

--

e11

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p1

p2 p3 p22

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
581.5, 21.0
28.9581404709197, 46.959146709599516

sCD14

--

e12

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p55

p2 p24

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
315.0, 118.0
26.0, 60.0

mCD14

--

e13

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p56

p3 p25

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
530.5, 126.0
43.0, 60.0

LPS:LBP:mCD14

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p3

p9 p26

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
726.5, 66.0
43.0, 60.0

LPS:LBP:sCD14

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p11 p27

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
798.5, 234.0
34.1335676625659, 52.51318101933216

TLR4

--

e16

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p57

p9 p11 p28

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
714.0, 299.5
52.912054739384175, 32.62910042262024

MYD88

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

p58

p4 p29

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
794.0, 358.0
36.0, 60.0

LPS:LBP:CD14:TLR4

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9 p11

p4 p30

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
581.0, 270.5
46.559999999999995, 34.919999999999995

SIIK

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

p65

p5 p42

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
43.75, 133.9969080091176
792.4561480998934, 1150.646327041044

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
596.0, 377.5
48.15999999999998, 36.11999999999998

SIIK{active}

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

p5

p6 p41

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
452.5, 235.0
30.95371302072853, 50.19521030388409

TRAF6

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

p64

p6 p43

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
396.5, 307.0
30.812235862346554, 49.96578788488629

TRAF6{active}

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

p6

p7 p44

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
343.5, 374.0
49.0, 60.0

NFKB:IKB

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p66

p7 p45

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
451.0, 464.5
50.0140873415174, 30.842020527269064

NFKB{active}

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

p7

p8 p16 p46

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
602.0, 467.5
43.999999999999986, 32.99999999999999

IKB

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

p7

p40

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
422.0, 610.5
44.14570336083719, 27.223183739182932

NFKB[active}

--

e26

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p8 p16

p10 p17 p18 p19 p20 p47

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
194.0, 660.0
60.0, 32.0

mRNA

--

e27

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p10 p15

p48

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
794.0, 462.0
36.0, 60.0

LPS:LBP:CD14:TLR4:MYD88

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p5 p31

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
794.5, 561.0
34.88752196836555, 53.673110720562384

TOLL

--

e29

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p60

p12 p34

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
59.59912296199789, 149.8460309711156
760.7579021758977, 1118.9480811170495

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
795.5, 739.0
33.0597539543058, 50.86115992970123

IL-1R

--

e30

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p61

p13 p36

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
926.0, 525.5
49.965787884886296, 30.81223586234655

spatzle

--

e31

cso30:c:Protein

cso30:i:CC_Extracellular

--

p59

p12 p32

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
955.0, 736.5
42.559999999999995, 31.920000000000005

IL-1

--

e32

cso30:c:Protein

cso30:i:CC_Extracellular

--

p62

p13 p33

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
796.5, 646.0
31.0, 60.0

TOLL:Spatzle

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

p14 p35

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
796.5, 826.0
31.0, 60.0

IL-1R:IL-1

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

p16 p37

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
651.5, 542.0
32.05574562286174, 51.98229019923526

Dorsal

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

p63

p14 p38

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
575.5, 698.0
32.05574562286174, 51.98229019923526

Dorsal

--

e36

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p14

p15 p39

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
222.0, 744.0
60.0, 32.0

IL-1

--

e38

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p17

p49

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
306.0, 816.0
60.0, 32.0

IL-6

--

e39

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p18

p50

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
88.92000044169403, 177.58199615461155
702.116147216506, 1063.4761507500555

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
410.0, 860.0
60.0, 32.0

IL-8

--

e40

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p20

p51

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
498.0, 776.0
60.0, 32.0

B7.1

--

e41

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p19

p52

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
98.0, 23.0
60.0, 34.0

LPS

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Cell_WithoutCellWall_

--

p53

p1 p21

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
123.0, 561.0
554.5904596813168, 502.9526142733732

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
182.8999006732147, 572.9192457801867
324.2856691618873, 487.46126065098986

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
130.2292983571121, 567.7129199030322
540.1318629670925, 489.52677446730746

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
131.26205526527093, 568.7456768111913
538.0663491507744, 487.46126065098986

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
123.0, 561.0
554.5904596813168, 502.9526142733732

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
123.0, 561.0
554.5904596813168, 502.9526142733732

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
131.26205526527093, 568.7456768111913
538.0663491507744, 487.46126065098986

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
527.8407079982793, 767.5513816317755
34.64776472134861, 31.36534490564193

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
436.9581000802984, 912.137348774018
98.1119062750932, 88.81709410166346

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
123.0, 561.0
554.5904596813168, 502.9526142733732

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
406.0, 18.5
43.529885288790496, 26.843429261420813

LBP

--

e6

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p54

p1 p23

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
253.7138508811562, 784.5079858514215
17.563064973025472, 8.456290542567828

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
253.12737042801837, 759.2893263665039
60.11424644660626, 108.20564360389132

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
278.3460299129366, 829.6669807430189
9.383687250201945, 9.383687250201953

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
54.16171792277359, 138.62719979140692
777.1525926265514, 1101.2051496996141

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
56.93817603551322, 158.06240658058445
745.5317424784871, 1082.5120900787622

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
64.3420643361522, 177.49761336976155
742.1279811242706, 1068.315215270367

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
297.0, 25.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e5 e6

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m6*0.1

nodelay

--

true

0

false

PMID: 10669111 In this scheme, LBP complexes with monomeric LPS derived from circulating micelles and catalytically transfers it to CD14, either on the plasma membrane of host cells or in the serum

Go back
297.0, 593.0
30.0, 30.0

p10

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 10669111 TLR4 is involved in LPS signaling leading to LPS-mediated NF-kB activation and transcription of immune response genes. Activation of these two transmembrane receptors by their respective ligands, Sp?tzle and IL-1, trigger parallel signaling pathways that culminate in nuclear translocation of the Drosophila protein dorsal and its mammalian homolog NF-kB, both of which stimulate gene transcription.

Go back
893.0, 133.0
30.0, 30.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e16 e15

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c25 : 1
stoichiometry:c28 : 1

m16*m15*0.1

nodelay

--

true

0

false

PMID: 10669111 TLR4 is involved in LPS signaling leading to LPS-mediated NF-kB activation and transcription of immune response genes.

Go back
889.0, 605.0
30.0, 30.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cell

--

e31 e29

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m31*m29*0.1

nodelay

--

true

0

false

PMID: 10669111 Activation of these two transmembrane receptors (TOLL and IL-1R) by their respective ligands, Sp?tzle and IL-1, trigger parallel signaling pathways that culminate in nuclear translocation of the Drosophila protein dorsal and its mammalian homolog NF-kB, both of which stimulate gene transcription.

Go back
897.0, 661.0
30.0, 30.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cell

--

e30 e32

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m30*m32*0.1

nodelay

--

true

0

false

PMID: 10669111 Activation of these two transmembrane receptors (TOLL and IL-1R) by their respective ligands, Sp?tzle and IL-1, trigger parallel signaling pathways that culminate in nuclear translocation of the Drosophila protein dorsal and its mammalian homolog NF-kB, both of which stimulate gene transcription.

Go back
689.0, 657.0
30.0, 30.0

p14

p14

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e35 e33

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m35*m33*0.1

nodelay

--

true

0

false

PMID: 10669111 Activation of these two transmembrane receptors (TOLL and IL-1R)by their respective ligands, Sp?tzle and IL-1, trigger parallel signaling pathways that culminate in nuclear translocation of the Drosophila protein dorsal and its mammalian homolog NF-kB, both of which stimulate gene transcription.

Go back
489.0, 633.0
30.0, 30.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e36

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c55 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 10669111 Activation of these two transmembrane receptors (TOLL and IL-1R)by their respective ligands, Sp?tzle and IL-1, trigger parallel signaling pathways that culminate in nuclear translocation of the Drosophila protein dorsal and its mammalian homolog NF-kB, both of which stimulate gene transcription.

Go back
553.0, 525.0
30.0, 30.0

p16

p16

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e34 e24

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m34*m24*0.1

nodelay

--

true

0

false

PMID: 10669111 Activation of these two transmembrane receptors (TOLL and IL-1R)by their respective ligands, Sp?tzle and IL-1, trigger parallel signaling pathways that culminate in nuclear translocation of the Drosophila protein dorsal and its mammalian homolog NF-kB, both of which stimulate gene transcription.

Go back
317.0, 661.0
30.0, 30.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e26

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c51 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 10669111 Stable transfection and expression of a constitutively- active form of hToll (TLR4) activated NF-kB and stimulated transcriptional activation of several inflammatory cytokines including IL-1, IL-6 and IL-8 as well as the costimulatory molecule B7.1 which is necessary for differentiation of naive T cells.

Go back
349.0, 725.0
30.0, 30.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e26

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c52 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 10669111 Stable transfection and expression of a constitutively- active form of hToll (TLR4) activated NF-kB and stimulated transcriptional activation of several inflammatory cytokines including IL-1, IL-6 and IL-8 as well as the costimulatory molecule B7.1 which is necessary for differentiation of naive T cells.

Go back
489.0, 697.0
30.0, 30.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e26

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c54 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 10669111 Stable transfection and expression of a constitutively- active form of hToll (TLR4) activated NF-kB and stimulated transcriptional activation of several inflammatory cytokines including IL-1, IL-6 and IL-8 as well as the costimulatory molecule B7.1 which is necessary for differentiation of naive T cells.

Go back
477.0, 45.0
30.0, 30.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 e12

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c9 : 1

m11*m12*0.1

nodelay

--

true

0

false

PMID: 10669111 In this scheme, LBP complexes with monomeric LPS derived from circulating micelles and catalytically transfers it to CD14, either on the plasma membrane of host cells or in the serum

Go back
417.0, 753.0
30.0, 30.0

p20

p20

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e26

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c53 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 10669111 Stable transfection and expression of a constitutively- active form of hToll (TLR4) activated NF-kB and stimulated transcriptional activation of several inflammatory cytokines including IL-1, IL-6 and IL-8 as well as the costimulatory molecule B7.1 which is necessary for differentiation of naive T cells.

Go back
61.0, 73.0
30.0, 30.0

p21

p21

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e5

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1

m5*0.1

nodelay

--

true

0

false

--

Go back
169.0, 113.0
30.0, 30.0

p22

p22

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e11

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1

m11*0.1

nodelay

--

true

0

false

--

Go back
473.0, 13.0
30.0, 30.0

p23

p23

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e6

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1

m6*0.1

nodelay

--

true

0

false

--

Go back
621.0, 13.0
30.0, 30.0

p24

p24

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e12

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1

m12*0.1

nodelay

--

true

0

false

--

Go back
385.0, 157.0
30.0, 30.0

p25

p25

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e13

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1

m13*0.1

nodelay

--

true

0

false

--

Go back
609.0, 129.0
30.0, 30.0

p26

p26

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e14

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1

m14*0.1

nodelay

--

true

0

false

--

Go back
773.0, 25.0
30.0, 30.0

p27

p27

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e15

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1

m15*0.1

nodelay

--

true

0

false

--

Go back
753.0, 225.0
30.0, 30.0

p28

p28

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e16

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1

m16*0.1

nodelay

--

true

0

false

--

Go back
709.0, 245.0
30.0, 30.0

p29

p29

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e17

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1

m17*0.1

nodelay

--

true

0

false

--

Go back
389.0, 93.0
30.0, 30.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 e13

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c8 : 1

m11*m13*0.1

nodelay

--

true

0

false

PMID: 10669111 In this scheme, LBP complexes with monomeric LPS derived from circulating micelles and catalytically transfers it to CD14, either on the plasma membrane of host cells or in the serum

Go back
837.0, 409.0
30.0, 30.0

p30

p30

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e18

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1

m18*0.1

nodelay

--

true

0

false

--

Go back
837.0, 493.0
30.0, 30.0

p31

p31

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e28

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1

m28*0.1

nodelay

--

true

0

false

--

Go back
989.0, 497.0
30.0, 30.0

p32

p32

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e31

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1

m31*0.1

nodelay

--

true

0

false

--

Go back
1009.0, 741.0
30.0, 30.0

p33

p33

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e32

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1

m32*0.1

nodelay

--

true

0

false

--

Go back
845.0, 549.0
30.0, 30.0

p34

p34

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e29

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1

m29*0.1

nodelay

--

true

0

false

--

Go back
833.0, 621.0
30.0, 30.0

p35

p35

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e33

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1

m33*0.1

nodelay

--

true

0

false

--

Go back
833.0, 709.0
30.0, 30.0

p36

p36

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e30

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1

m30*0.1

nodelay

--

true

0

false

--

Go back
849.0, 837.0
30.0, 30.0

p37

p37

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e34

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1

m34*0.1

nodelay

--

true

0

false

--

Go back
701.0, 565.0
30.0, 30.0

p38

p38

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e35

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1

m35*0.1

nodelay

--

true

0

false

--

Go back
621.0, 761.0
30.0, 30.0

p39

p39

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e36

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1

m36*0.1

nodelay

--

true

0

false

--

Go back
909.0, 329.0
30.0, 30.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 e18

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c32 : 1
stoichiometry:c15 : 1

m17*m18*0.1

nodelay

--

true

0

false

PMID: 10669111 TLR4 is involved in LPS signaling leading to LPS-mediated NF-kB activation and transcription of immune response genes.

Go back
665.0, 477.0
30.0, 30.0

p40

p40

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e25

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1

m25*0.1

nodelay

--

true

0

false

--

Go back
649.0, 413.0
30.0, 30.0

p41

p41

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e20

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1

m20*0.1

nodelay

--

true

0

false

--

Go back
641.0, 245.0
30.0, 30.0

p42

p42

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e19

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1

m19*0.1

nodelay

--

true

0

false

--

Go back
497.0, 237.0
30.0, 30.0

p43

p43

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e21

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1

m21*0.1

nodelay

--

true

0

false

--

Go back
393.0, 265.0
30.0, 30.0

p44

p44

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e22

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1

m22*0.1

nodelay

--

true

0

false

--

Go back
313.0, 313.0
30.0, 30.0

p45

p45

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e23

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1

m23*0.1

nodelay

--

true

0

false

--

Go back
529.0, 465.0
30.0, 30.0

p46

p46

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e24

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1

m24*0.1

nodelay

--

true

0

false

--

Go back
437.0, 553.0
30.0, 30.0

p47

p47

cso30:i:ME_UnknownDegradation

cso30:i:CC_NuclearOuterMembrane

--

e26

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1

m26*0.1

nodelay

--

true

0

false

--

Go back
169.0, 709.0
30.0, 30.0

p48

p48

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e27

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1

m27*0.1

nodelay

--

true

0

false

--

Go back
221.0, 797.0
30.0, 30.0

p49

p49

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e38

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1

m38*0.1

nodelay

--

true

0

false

--

Go back
689.0, 377.0
30.0, 30.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c29 : 1

m28*m19*0.1

nodelay

--

true

0

false

PMID: 10669111 TLR4 is involved in LPS signaling leading to LPS-mediated NF-kB activation and transcription of immune response genes.

Go back
321.0, 869.0
30.0, 30.0

p50

p50

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e39

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1

m39*0.1

nodelay

--

true

0

false

--

Go back
457.0, 905.0
30.0, 30.0

p51

p51

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleolus

--

e40

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1

m40*0.1

nodelay

--

true

0

false

--

Go back
545.0, 825.0
30.0, 30.0

p52

p52

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e41

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1

m41*0.1

nodelay

--

true

0

false

--

Go back
29.0, 29.0
30.0, 30.0

p53

p53

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

--

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
377.0, 45.0
30.0, 30.0

p54

p54

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

--

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
541.0, 21.0
30.0, 30.0

p55

p55

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

--

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
269.0, 153.0
30.0, 30.0

p56

p56

cso30:i:ME_UnknownProduction

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
809.0, 189.0
30.0, 30.0

p57

p57

cso30:i:ME_UnknownProduction

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
661.0, 313.0
30.0, 30.0

p58

p58

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

--

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
973.0, 565.0
30.0, 30.0

p59

p59

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

--

e31

true true true true

--

and

custom

custom:0.01

0.01

nodelay

--

true

0

false

--

Go back
513.0, 301.0
30.0, 30.0

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m20*m21*0.1

nodelay

--

true

0

false

PMID: 10669111 TLR4 is involved in LPS signaling leading to LPS-mediated NF-kB activation and transcription of immune response genes.

Go back
813.0, 529.0
30.0, 30.0

p60

p60

cso30:i:ME_UnknownProduction

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
833.0, 765.0
30.0, 30.0

p61

p61

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

--

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
973.0, 793.0
30.0, 30.0

p62

p62

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

--

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
693.0, 529.0
30.0, 30.0

p63

p63

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

--

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
473.0, 197.0
30.0, 30.0

p64

p64

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

--

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
593.0, 217.0
30.0, 30.0

p65

p65

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

--

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
289.0, 421.0
30.0, 30.0

p66

p66

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

--

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
481.0, 389.0
30.0, 30.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e22 e23

e25 e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m22*m23*0.1

nodelay

--

true

0

false

PMID: 10669111 TLR4 is involved in LPS signaling leading to LPS-mediated NF-kB activation and transcription of immune response genes.

Go back
321.0, 485.0
30.0, 30.0

p8

p8

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e24

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 10669111 TLR4 is involved in LPS signaling leading to LPS-mediated NF-kB activation and transcription of immune response genes.

Go back
937.0, 229.0
30.0, 30.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e16 e14

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c30 : 1
stoichiometry:c10 : 1

m16*m14*0.1

nodelay

--

true

0

false

PMID: 10669111 TLR4 is involved in LPS signaling leading to LPS-mediated NF-kB activation and transcription of immune response genes.

Go back
158.0, 40.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
835.5781158511729, 259.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
319.0, 419.46184854067815

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
767.0, 320.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.0, 246.91699286388103

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.8874480940947, 411.4164522465671

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
621.0, 305.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
834.8465862187206, 359.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
549.020613557655, 334.2680368629481

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
483.0, 275.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
434.9232391629239, 318.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
427.0, 345.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
334.98402490518174, 34.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
393.0, 404.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
511.0, 413.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
482.019375177176, 419.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
358.92273397339466, 484.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.0, 515.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
770.0, 103.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
334.94690449522324, 610.9201678889206

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
251.3409919128368, 620.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
826.9711254108329, 163.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.9921104517297, 393.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
248.80475655636832, 49.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
574.0, 161.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.0, 169.19165839362657

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.0, 352.92230218178327

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.0745671513299, 556.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.0, 594.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
834.7902327210916, 629.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
829.0, 694.2929730966948

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
930.0950515759703, 697.1676940130167

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
831.8808071436715, 691.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
677.0, 594.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
242.0, 97.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.9940893970505, 673.3074649768097

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
615.2425972889785, 679.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
525.0665337597682, 666.2150904250639

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
96.81610522039854, 57.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
584.8896558804394, 561.3317663705229

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
500.0, 495.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
470.5988186955916, 550.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.2494651199621, 634.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
378.54186364642925, 638.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
433.6930369309187, 638.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
341.0, 119.69547535069574

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.0, 638.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
272.5470429750542, 691.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
343.26413974855546, 755.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
433.0, 783.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.0, 727.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
261.95860331201504, 649.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
197.96911150685466, 106.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
341.0, 152.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
450.0, 29.347497794210454

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
610.0, 35.73394450469363

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
242.0, 63.04625518531076

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
574.0, 147.35171052088677

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.0, 61.469888674425505

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.3292586792176, 249.20655067215768

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.1570394041597, 282.7037121577134

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.0, 406.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 492.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
976.0, 523.7927985842801

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.0, 574.5777087639997

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.0, 657.020613557655

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
826.0, 738.6499055497528

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
514.8995250553337, 46.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
998.0, 752.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.0, 853.758472741024

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
608.0, 742.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
684.0, 572.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
646.0, 486.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
620.0, 396.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
628.0, 272.79279858428015

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
483.0, 255.13137084989847

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
409.0, 303.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.66914335816205, 350.1089652564389

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.0, 113.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.0, 480.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.0, 590.9195959492894

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
201.0856580228888, 692.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
243.19776902317903, 776.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
336.0, 848.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
452.0, 892.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
539.0, 808.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
59.0, 41.409718015785266

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.0, 49.95715430863216

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
299.0, 157.20655067215768

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
507.0, 62.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
820.0573097607281, 219.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
571.0, 40.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.0, 322.37072939801

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.6079254665552, 559.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
970.3149107106393, 561.9792745494693

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

--

Go back
981.5689290811055, 775.8446454055273

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
819.3531602401445, 767.1513543886333

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
690.6564023547028, 551.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
472.9922778767137, 227.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
605.6643638388299, 247.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back