1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/11073096.csml convertedTime:2009.07.01.10:38

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Cellular signaling in macrophage migration and chemotaxis.
Authors Jones GE.
Affiliation The Randall Centre for Molecular Mechanisms of Cell Function, King's CollegeLondon, United Kingdom. gareth.jones@kcl.ac.uk
Abstract Whereas most cells in adult tissues are fixed in place by cell junctions,leukocytes are motile and able to migrate actively through the walls of bloodvessels into surrounding tissues. The actin cytoskeleton of these cells plays acentral role in locomotion, phagocytosis, and the regulation of cell shape thatare crucial elements of neutrophil and monocyte/macrophage function. This reviewwill concentrate on how macrophages in particular control the actin cytoskeletonto generate cell movement and the shape changes required for chemotaxis. It hasrecently become evident that a complex of seven proteins known as the Arp2/3complex regulates the assembly of new actin filament networks at the leadingfront of moving cells. Proteins of the Wiskott-Aldrich Syndrome Protein (WASP)family bind directly to the Arp2/3 complex and stimulate its ability to promotethe nucleation of new actin filaments. Upstream of the WASP family proteins,receptor tyrosine kinases, G-protein-coupled receptors, phosphoinositide-3-OHkinase (PI 3-kinase), and the Rho family of GTPases receive and transduce thesignals that lead to actin nucleation through WASP-Arp2/3 action. Although manygaps remain in our understanding, we are now in a position to considercompleting signaling pathways that are initiated from outside the cell to theactin rearrangements that drive cell motility and chemotaxis.
PMID 11073096
Model Abstract

Entity

MO000000012:Grb-2 MO000000021:Cdc42 MO000000030:PI3K MO000000044:Vav MO000000100:M-CSF MO000000143:Fyn MO000000144:Lyn MO000000166:Rac1 MO000000306:ICAM-1 MO000000315:trimeric G-proteins(alpha+beta+gamma subunit) MO000000331:PIP2 MO000002553:CD44 MO000007995:M-CSF-1-R MO000016577:RhoA MO000016777:Sos MO000017251:IQGAP1 MO000017272:PIP3 MO000017392:RhoGEF MO000017852:WASP MO000018441:PAK MO000019590:mDia1 MO000019591:profilin MO000019600:GDIs MO000019632:Arp2/3 complex MO000023102:moesin MO000023103:ezrin MO000033467:fMLP-R MO000033474:fMLP MO000035548:radixin MO000036321:RhoGDI MO000036806:CIP4 MO000105858:DB1 e1: e10:serpentine receptor:trimeric G-proteins:GDP e11:serpentine receptor: Leukotrines:G-proteins:GDP e12:chemokines e13:chemokines:serpentine receptor:G-proteins:GDP e14:Complement factors e15:serpentine receptor:complement factors:G-proteins:GDP e16:GDP e17:Gproteins:GDP e18:serpentine receptor:Bacterial component:G-proteins:GTP e19:serpentine receptor:Leukotrines:G-proteins:GTP e2: e20:GTP e21:serpentine receptor:chemokines:G-proteins:GTP e22:serpentine receptor:complement factors:G-proteins:GTP e23:Alpha subunit:GTP e24:Beta:Gamma subunit e25:PLC e26:Alpha subunit:GDP:PLC{active} e27:M-CSF(2):M-CSF-1-R e28:Alpha subunit:GDP:PI 3-Kinase {active} e29:adenyl cyclase e3: e30:Alpha subunit:GDP:Adenyl cyclase{active} e31:Beta:Gammasubunit:adenyl cyclase{active} e32:Beta:Gammasubunit:PI 3 Kinase{active} e33:Beta:Gammasubunit:PLC{active} e34:p110 catalytic subunit e35:M-CSF(2):M-CSF-1-R(2) e36:101kDa Regulatory subunit e37:M-CSF(2):M-CSF-1-R(2){p} e38:p85 e39:MCSF(2):M-CSF-1-R(2){p}:PI3K (p110:p85) e4: e41:MCSF(2):M-CSF-1-R (2) {p}:PI3K(p110:p85):Grb2 e42:C3 transferase e43:Rho e44:Rho:ADP:Ribose e45:Rho{inactive} e46:ADP e47:Ribose e48:Vav:PIP3 e49:extracellular components e5:serpentine receptor e6:Bacterial component e63:Vav{p} e64:Rac e65:Rho:Rac:Cdc42:GDIs e66:RhoGDI:RhoA:Rac1:Cdc42 e67:RhoGDI:ezrin:radixin:moesin e68:RhoGDI:RhoA:Rac1:moesin:CD44 e69:RhoGDI:RhoA:Rac1:moesin:ICAM-1 e7:serpentine receptor:Bacterial component:Gproteins:GDP e70:Actin e71:RhoGDI:RhoA:Rac1:moesin:actin e72:RhoGEF:ezrin:moesin:radixin e73:DB1:ezrin:moesin:radixin e74:Rac{active} e75:Tiam1 e76:PIP3:Tiam1 e77:PIP3:Sos e78:fMLP:fMLP-R e79:Lyn{active} e8:Leukotrines e80:IQGAP1:Rac e81:Cdc42:CIP4 e82:IQGAP1:Cdc42 e83:ROK e84:Mysosin II Light chain Kinase e85:Mysosin II Light chain Kinase{p} e86:Myosin I heavy chain e87:Myosin I heavy chain{p} e88:mDia1:profilin e89:WASP:Cdc42 e9:M-CSF(2) e90:WASP:Grb2 e91:Nck e92:WASP:Nck e93:WASP:profilin e94:WASP:Fyn e95:WASP:Arp2/3 complex

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p7 p8 p9
Model Detail
673.0, 878.0
22.0, 22.0

Grb-2

--

MO000000012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32 p57

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000012

--

Go back
638.0, 975.0
20.0, 20.0

Cdc42

--

MO000000021

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p38 p51 p52 p56

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
InterProIPR003577
TRANSPATHMO000000021

--

Go back
543.0, 652.0
26.0, 26.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21 p28

p16 p19 p29

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
936.0, 316.0
24.0, 24.0

Vav

--

MO000000044

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p36

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000044

--

Go back
237.0, 558.0
21.0, 21.0

M-CSF

--

MO000000100

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m89

10

false

infinite

0

unit false false false
InterProIPR008001
TRANSPATHMO000000100

--

Go back
1137.0, 1082.0
22.0, 22.0

Fyn

--

MO000000143

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m127

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000143

--

Go back
1109.0, 1262.0
22.0, 22.0

Lyn

--

MO000000144

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m128

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000144

--

Go back
817.0, 1046.0
22.0, 22.0

Rac1

--

MO000000166

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m146

10

false

infinite

0

unit false false false
TRANSPATHMO000000166

--

Go back
1188.0, 949.0
32.0, 32.0

ICAM-1

--

MO000000306

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m242

10

false

infinite

0

unit false false false
InterProIPR003987
TRANSPATHMO000000306

--

Go back
433.0, 170.0
21.0, 21.0

trimeric G-proteins(alpha+beta+gamma subunit)

--

MO000000315

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m250

10

false

infinite

0

unit false false false
TRANSPATHMO000000315

--

Go back
323.0, 1064.0
26.0, 26.0

PIP2

--

MO000000331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p23 p31

true true true true

csml-variable:Double

m290229

10

false

infinite

0

unit false false false
TRANSPATHMO000000331

--

Go back
1192.0, 913.0
24.0, 24.0

CD44

--

MO000002553

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m399

10

false

infinite

0

unit false false false
InterProIPR001231
TRANSPATHMO000002553

--

Go back
331.0, 668.0
26.0, 26.0

M-CSF-1-R

--

MO000007995

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p26

true true true true

csml-variable:Double

m1031

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000007995

--

Go back
759.0, 932.0
26.0, 26.0

RhoA

--

MO000016577

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m1574

10

false

infinite

0

unit false false false
InterProIPR005225
TRANSPATHMO000016577

--

Go back
390.0, 1347.0
20.0, 20.0

Sos

--

MO000016777

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m1720

10

false

infinite

0

unit false false false
TRANSPATHMO000016777

--

Go back
697.0, 1162.0
22.0, 22.0

IQGAP1

--

MO000017251

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50 p51

true true true true

csml-variable:Double

m2107

10

false

infinite

0

unit false false false
InterProIPR008936
TRANSPATHMO000017251

--

Go back
328.0, 1153.0
24.0, 24.0

PIP3

--

MO000017272

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22 p23 p31

p35 p46 p47

true true true true

csml-variable:Double

m157492

10

false

infinite

0

unit false false false
TRANSPATHMO000017272

--

Go back
649.0, 766.0
22.0, 22.0

RhoGEF

--

MO000017392

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m2225

10

false

infinite

0

unit false false false
InterProIPR001849
TRANSPATHMO000017392

--

Go back
913.0, 970.0
22.0, 22.0

WASP

--

MO000017852

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56 p57 p58 p59 p60 p61

true true true true

csml-variable:Double

m2602

10

false

infinite

0

unit false false false
InterProIPR000697
TRANSPATHMO000017852

--

Go back
815.0, 1188.0
18.0, 18.0

PAK

--

MO000018441

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m3079

10

false

infinite

0

unit false false false
TRANSPATHMO000018441

--

Go back
853.0, 1170.0
22.0, 22.0

mDia1

--

MO000019590

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m4134

10

false

infinite

0

unit false false false
InterProIPR003104
TRANSPATHMO000019590

--

Go back
937.0, 1142.0
21.0, 21.0

profilin

--

MO000019591

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55 p59

true true true true

csml-variable:Double

m4135

10

false

infinite

0

unit false false false
TRANSPATHMO000019591

--

Go back
568.0, 1009.0
24.0, 24.0

GDIs

--

MO000019600

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m4142

10

false

infinite

0

unit false false false
TRANSPATHMO000019600

--

Go back
1084.0, 1321.0
24.0, 24.0

Arp2/3 complex

--

MO000019632

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m4169

10

false

infinite

0

unit false false false
TRANSPATHMO000019632

--

Go back
848.0, 817.0
24.0, 24.0

moesin

--

MO000023102

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p43 p44

true true true true

csml-variable:Double

m6914

10

false

infinite

0

unit false false false
InterProIPR008954
TRANSPATHMO000023102

--

Go back
768.0, 789.0
24.0, 24.0

ezrin

--

MO000023103

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p43 p44

true true true true

csml-variable:Double

m6915

10

false

infinite

0

unit false false false
InterProIPR008954
TRANSPATHMO000023103

--

Go back
1194.0, 1127.0
28.0, 28.0

fMLP-R

--

MO000033467

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m12151

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000033467

--

Go back
1278.0, 1123.0
28.0, 28.0

fMLP

--

MO000033474

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m138859

10

false

infinite

0

unit false false false
TRANSPATHMO000033474

--

Go back
698.0, 851.0
28.0, 28.0

radixin

--

MO000035548

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p43 p44

true true true true

csml-variable:Double

m14041

10

false

infinite

0

unit false false false
InterProIPR008954
TRANSPATHMO000035548

--

Go back
673.0, 930.0
29.0, 29.0

RhoGDI

--

MO000036321

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p39

true true true true

csml-variable:Double

m14748

10

false

infinite

0

unit false false false
TRANSPATHMO000036321

--

Go back
762.0, 1031.0
20.0, 20.0

CIP4

--

MO000036806

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m15135

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000036806

--

Go back
541.0, 826.0
22.0, 22.0

DB1

--

MO000105858

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m78700

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000105858

--

Go back
305.43322375524946, 92.5447680918425
937.563957209059, 1379.2455913587269

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
330.0, 126.0
26.99999999999999, 30.000000000000004

serpentine receptor:trimeric G-proteins:GDP

--

e10

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p5

p1 p3 p4 p2

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
474.5, 86.0
19.751370313527733, 38.228458671344

serpentine receptor: Leukotrines:G-proteins:GDP

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p8

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
767.5, 35.0
17.200643992755083, 27.892936204467713

chemokines

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
726.5, 98.0
19.744573558430165, 38.21530366147773

chemokines:serpentine receptor:G-proteins:GDP

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p9

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
962.0, 42.0
12.756782039289048, 29.438727782974734

Complement factors

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
978.5, 86.0
19.561061170795877, 37.86011839508879

serpentine receptor:complement factors:G-proteins:GDP

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p10

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
553.0, 304.5
30.28790786948176, 16.65834932821497

GDP

--

e16

cso30:c:SmallMolecule

cso30:i:CC_Cytoplasm

--

p7 p8 p9 p10

p6

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
373.2800000000001, 248.5
44.96000000000001, 33.72

Gproteins:GDP

--

e17

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p6

p5

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
332.5, 310.0
23.469195351896506, 45.424249068186796

serpentine receptor:Bacterial component:G-proteins:GTP

--

e18

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p7

p11

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
332.5, 382.0
23.469195351896506, 45.424249068186796

serpentine receptor:Leukotrines:G-proteins:GTP

--

e19

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p8

p12

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
305.43322375524946, 92.5447680918425
937.563957209059, 1379.2455913587269

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
513.0, 176.5
29.443378119001924, 16.193857965451055

GTP

--

e20

cso30:c:SmallMolecule

cso30:i:CC_Cytoplasm

--

--

p7 p8 p9 p10 p56

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1116.5, 133.0
23.469195351896506, 45.424249068186796

serpentine receptor:chemokines:G-proteins:GTP

--

e21

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p9

p13

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1196.5, 222.0
23.469195351896506, 45.424249068186796

serpentine receptor:complement factors:G-proteins:GTP

--

e22

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p10

p14

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
624.0, 343.5
31.708593278325623, 19.553632521634142

Alpha subunit:GTP

--

e23

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p11 p12 p13 p14

p15 p16 p17

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
687.5, 398.0
24.26728878520247, 29.715047492084658

Beta:Gamma subunit

--

e24

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p11 p12 p13 p14

p18 p19 p20

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
465.0, 478.0
21.5, 21.5

PLC

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p20

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000132

--

Go back
540.0, 579.0
24.911602209944746, 27.679558011049718

Alpha subunit:GDP:PLC{active}

--

e26

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p15

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
332.5, 729.0
23.09010827674803, 32.218755734997245

M-CSF(2):M-CSF-1-R

--

e27

cso30:c:Complex

cso30:i:CC_Extracellular

--

p25

p26

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
620.0, 547.0
24.911602209944746, 27.679558011049718

Alpha subunit:GDP:PI 3-Kinase {active}

--

e28

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p16

p22

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
774.0, 458.0
12.927034611786716, 29.83161833489241

adenyl cyclase

--

e29

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p17 p18

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
324.18450289943047, 111.54264125105358
900.0613989206976, 1341.2498450403057

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
720.0, 523.0
24.911602209944746, 27.679558011049718

Alpha subunit:GDP:Adenyl cyclase{active}

--

e30

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p17

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
872.5, 381.0
23.476784731143344, 32.75830427601397

Beta:Gammasubunit:adenyl cyclase{active}

--

e31

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p18

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
612.5, 848.0
23.476784731143344, 32.75830427601397

Beta:Gammasubunit:PI 3 Kinase{active}

--

e32

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p19

p23

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
616.5, 701.0
23.476784731143344, 32.75830427601397

Beta:Gammasubunit:PLC{active}

--

e33

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p20

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
385.0, 439.5
29.812839605554416, 18.38458442342523

p110 catalytic subunit

--

e34

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p21 p28

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
333.0, 787.0
21.794117647058822, 36.32352941176471

M-CSF(2):M-CSF-1-R(2)

--

e35

cso30:c:Complex

cso30:i:CC_Extracellular

--

p26

p27

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
399.0, 507.5
25.439999999999998, 19.08

101kDa Regulatory subunit

--

e36

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p21

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
329.0, 851.0
21.794117647058822, 36.32352941176471

M-CSF(2):M-CSF-1-R(2){p}

--

e37

cso30:c:Complex

cso30:i:CC_Extracellular

--

p27

p29 p45

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
398.0, 634.5
27.520000000000007, 20.640000000000004

p85

--

e38

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p28

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
327.0, 920.0
25.05882352941176, 41.764705882352956

MCSF(2):M-CSF-1-R(2){p}:PI3K (p110:p85)

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p31 p32

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
358.87436931616594, 144.78891927967294
830.6816660872266, 1274.757288983066

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
324.0, 989.0
23.91176470588236, 39.852941176470594

MCSF(2):M-CSF-1-R (2) {p}:PI3K(p110:p85):Grb2

--

e41

cso30:c:Complex

cso30:i:CC_Extracellular

--

p32

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
245.0, 1321.0
13.76613657623947, 31.768007483629553

C3 transferase

--

e42

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p33

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
486.0, 1074.5
28.000000000000007, 21.000000000000004

Rho

--

e43

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p33 p37

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
521.5, 1125.0
28.243163883281348, 39.40906588364838

Rho:ADP:Ribose

--

e44

cso30:c:Complex

cso30:i:CC_Extracellular

--

p33

p34

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
438.0, 1038.5
28.000000000000007, 21.000000000000004

Rho{inactive}

--

e45

cso30:c:Protein

cso30:i:CC_Extracellular

--

p34

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
401.0, 1192.5
30.556621880998076, 16.80614203454894

ADP

--

e46

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p33

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
479.0, 1200.5
33.41139383021843, 16.14884035127224

Ribose

--

e47

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p33

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1009.0, 361.0
21.480662983425418, 23.867403314917123

Vav:PIP3

--

e48

cso30:c:Complex

cso30:i:CC_Extracellular

--

p35

p36

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1263.0, 300.5
25.65905096660808, 16.678383128295255

extracellular components

--

e49

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p36

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
323.5, 190.0
24.69771528998242, 37.996485061511414

serpentine receptor

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5 p62

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
326.0, 48.5
27.521968365553604, 17.88927943760984

Bacterial component

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
1052.0, 333.0
24.0, 24.0

Vav{p}

--

e63

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

--

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000044

--

Go back
484.0, 1011.5
31.467095995170048, 19.404709197021536

Rac

--

e64

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p37 p45 p50 p62

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
733.0, 1110.0
22.588235294117652, 37.64705882352942

Rho:Rac:Cdc42:GDIs

--

e65

cso30:c:Complex

cso30:i:CC_Extracellular

--

p37

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
820.0, 988.0
23.735294117647065, 39.558823529411775

RhoGDI:RhoA:Rac1:Cdc42

--

e66

cso30:c:Complex

cso30:i:CC_Extracellular

--

p38

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
913.0, 890.0
22.58823529411765, 37.64705882352941

RhoGDI:ezrin:radixin:moesin

--

e67

cso30:c:Complex

cso30:i:CC_Extracellular

--

p39

p40 p41 p42

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1192.0, 865.0
24.264705882352942, 40.44117647058825

RhoGDI:RhoA:Rac1:moesin:CD44

--

e68

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p40

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1196.0, 1017.0
24.264705882352942, 40.44117647058825

RhoGDI:RhoA:Rac1:moesin:ICAM-1

--

e69

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
405.5, 100.0
21.844770883578168, 42.280201710151296

serpentine receptor:Bacterial component:Gproteins:GDP

--

e7

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p7

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false false false

--

Go back
887.5, 856.0
16.47836586838398, 26.721674381163204

Actin

--

e70

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p42

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1032.0, 797.0
24.264705882352942, 40.44117647058825

RhoGDI:RhoA:Rac1:moesin:actin

--

e71

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p42

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
809.0, 727.0
21.970588235294112, 36.61764705882353

RhoGEF:ezrin:moesin:radixin

--

e72

cso30:c:Complex

cso30:i:CC_Extracellular

--

p43

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
537.0, 738.0
22.588235294117652, 37.64705882352942

DB1:ezrin:moesin:radixin

--

e73

cso30:c:Complex

cso30:i:CC_Extracellular

--

p44

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
432.0, 994.5
31.467095995170048, 19.404709197021536

Rac{active}

--

e74

cso30:c:Protein

cso30:i:CC_Extracellular

--

p45 p62

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
437.0, 1280.5
22.239999999999995, 16.680000000000003

Tiam1

--

e75

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p46

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
441.0, 1225.0
21.182320441988946, 23.535911602209943

PIP3:Tiam1

--

e76

cso30:c:Complex

cso30:i:CC_Extracellular

--

p46

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
432.5, 1339.0
23.246625562406265, 28.46525579070155

PIP3:Sos

--

e77

cso30:c:Complex

cso30:i:CC_Extracellular

--

p47

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
1194.5, 1198.0
19.581451436088578, 37.89958342468758

fMLP:fMLP-R

--

e78

cso30:c:Complex

cso30:i:CC_Extracellular

--

p48

p49

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
1041.0, 1254.0
22.0, 22.0

Lyn{active}

--

e79

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

--

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000144

--

Go back
613.0, 36.5
21.439999999999998, 16.080000000000002

Leukotrines

--

e8

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false

--

Go back
536.0, 1179.0
24.71270718232044, 27.458563535911615

IQGAP1:Rac

--

e80

cso30:c:Complex

cso30:i:CC_Extracellular

--

p50

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
889.5, 1088.0
20.503082819530075, 25.10581569738377

Cdc42:CIP4

--

e81

cso30:c:Complex

cso30:i:CC_Extracellular

--

p52

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
888.5, 1143.0
22.8056990501583, 27.925345775704045

IQGAP1:Cdc42

--

e82

cso30:c:Complex

cso30:i:CC_Extracellular

--

p51

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
608.0, 1171.5
31.648218957536727, 19.516401690480983

ROK

--

e83

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p53

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
684.0, 1224.0
15.128157156220766, 34.911131898971

Mysosin II Light chain Kinase

--

e84

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p53

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
520.0, 1272.0
15.128157156220766, 34.911131898971

Mysosin II Light chain Kinase{p}

--

e85

cso30:c:Protein

cso30:i:CC_Extracellular

--

p53

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
856.0, 1230.0
16.757717492984096, 38.67165575304021

Myosin I heavy chain

--

e86

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p54

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
792.0, 1270.0
16.757717492984096, 38.67165575304021

Myosin I heavy chain{p}

--

e87

cso30:c:Protein

cso30:i:CC_Extracellular

--

p54

--

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
904.5, 1279.0
22.634227628728546, 27.71538076987169

mDia1:profilin

--

e88

cso30:c:Complex

cso30:i:CC_Extracellular

--

p55

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
954.5, 1081.0
26.063656057323776, 31.91468088651891

WASP:Cdc42

--

e89

cso30:c:Complex

cso30:i:CC_Extracellular

--

p56

--

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
264.5, 611.0
22.46275620729879, 27.505415764039334

M-CSF(2)

--

e9

cso30:c:Complex

cso30:i:CC_Extracellular

--

p24

p25

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
1035.5, 1065.0
25.973837693717705, 31.8046992167972

WASP:Grb2

--

e90

cso30:c:Complex

cso30:i:CC_Extracellular

--

p57

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1058.0, 950.5
27.68, 20.76000000000001

Nck

--

e91

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p58

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
947.5, 950.0
24.463256123979335, 29.95500749875021

WASP:Nck

--

e92

cso30:c:Complex

cso30:i:CC_Extracellular

--

p58

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
988.5, 1198.0
23.965172471254775, 29.34510914847525

WASP:profilin

--

e93

cso30:c:Complex

cso30:i:CC_Extracellular

--

p59

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1075.5, 1117.0
25.973837693717716, 31.804699216797196

WASP:Fyn

--

e94

cso30:c:Complex

cso30:i:CC_Extracellular

--

p60

--

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
950.0, 1341.0
28.889502762430936, 32.09944751381216

WASP:Arp2/3 complex

--

e95

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p61

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
449.0, 46.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 e10

e7

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m6*m10*0.1

nodelay

--

true

0

false

PMID: 11073096,10427991,9704038 Cells are responsive to bacterial components, leukotrienes, complement factors, and chemokines, an ever-expanding family of attractants controlling leukocyte migration. All these attractants in both neutrophils and monocytes/macrophages interact with specific serpentine (heptahelical) receptors [13 ], embedded in the plasma membrane, that transduce ligand-induced signals by coupling to heterotrimeric G proteins

Go back
824.0, 233.0
23.0, 23.0

p7

p10

cso30:i:ME_GDP-GTPExchange

cso30:i:CC_Cytoplasm

--

e20 e15

e16 e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c32 : 1
stoichiometry:c34 : 1

m20*m15*0.1

nodelay

--

true

0

false

PMID: 11073096 Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.

Go back
501.0, 354.0
21.0, 21.0

p11

p11

cso30:i:ME_Dissociation

cso30:i:CC_Cytoplasm

--

e18

e23 e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 11073096 Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.

Go back
469.0, 398.0
21.0, 21.0

p11

p12

cso30:i:ME_Dissociation

cso30:i:CC_Cytoplasm

--

e19

e23 e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 11073096 Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.

Go back
717.0, 306.0
21.0, 21.0

p11

p13

cso30:i:ME_Dissociation

cso30:i:CC_Cytoplasm

--

e21

e23 e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 11073096 Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.

Go back
791.0, 336.0
18.0, 18.0

p11

p14

cso30:i:ME_Dissociation

cso30:i:CC_Cytoplasm

--

e22

e23 e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 11073096 Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.

Go back
541.0, 478.0
22.0, 22.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e23 e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m23*m25*0.1

nodelay

--

true

0

false

PMID: 11073096 The G protein complex dissociates into {alpha} and ?{gamma} subunits, which in turn bind and activate target enzymes such as phospholipase C, phosphoinositide 3-kinase (PI 3-kinase), or adenyl cyclase.

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620.0, 437.0
24.0, 24.0

p15

p16

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e23 MO000000030

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c75 : 1
stoichiometry:c52 : 1

m23*m37*0.1

nodelay

--

true

0

false

PMID: 11073096 The G protein complex dissociates into {alpha} and ?{gamma} subunits, which in turn bind and activate target enzymes such as phospholipase C, phosphoinositide 3-kinase (PI 3-kinase), or adenyl cyclase.

Go back
657.0, 462.0
22.0, 22.0

p15

p17

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e29 e23

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m29*m23*0.1

nodelay

--

true

0

false

PMID: 11073096 The G protein complex dissociates into {alpha} and ?{gamma} subunits, which in turn bind and activate target enzymes such as phospholipase C, phosphoinositide 3-kinase (PI 3-kinase), or adenyl cyclase.

Go back
797.0, 402.0
22.0, 22.0

p15

p18

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e24 e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m24*m29*0.1

nodelay

--

true

0

false

PMID: 11073096 The G protein complex dissociates into {alpha} and ?{gamma} subunits, which in turn bind and activate target enzymes such as phospholipase C, phosphoinositide 3-kinase (PI 3-kinase), or adenyl cyclase.

Go back
705.0, 721.0
22.0, 22.0

p15

p19

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e24 MO000000030

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c76 : 1
stoichiometry:c61 : 1

m24*m37*0.1

nodelay

--

true

0

false

PMID: 11073096 The G protein complex dissociates into {alpha} and ?{gamma} subunits, which in turn bind and activate target enzymes such as phospholipase C, phosphoinositide 3-kinase (PI 3-kinase), or adenyl cyclase.

Go back
509.0, 34.0
21.0, 21.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e8 e10

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c4 : 1
stoichiometry:c6 : 1

m8*m10*0.1

nodelay

--

true

0

false

PMID: 11073096,10427991,9704038 Cells are responsive to bacterial components, leukotrienes, complement factors, and chemokines, an ever-expanding family of attractants controlling leukocyte migration. All these attractants in both neutrophils and monocytes/macrophages interact with specific serpentine (heptahelical) receptors [13 ], embedded in the plasma membrane, that transduce ligand-induced signals by coupling to heterotrimeric G proteins

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641.0, 618.0
22.0, 22.0

p15

p20

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e25 e24

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m25*m24*0.1

nodelay

--

true

0

false

PMID: 11073096 The G protein complex dissociates into {alpha} and ?{gamma} subunits, which in turn bind and activate target enzymes such as phospholipase C, phosphoinositide 3-kinase (PI 3-kinase), or adenyl cyclase.

Go back
454.0, 439.0
19.0, 19.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e34 e36

MO000000030

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c74 : 1

m34*m36*0.1

nodelay

--

true

0

false

PMID:11073096,10579926 At least four Class I PI 3-kinase isoforms exist in mammalian cells, but only one form, a single Class IB variant containing the p110{gamma} catalytic subunit complexed with a 101-kDa regulatory protein, is thought to interact with G-proteins in leukocytes. PMID:11073096 he free G{alpha} and G?{gamma} subunits then interact with and modulate the activity of target proteins such as the Class 1B p101/p110{gamma} PI 3-kinase.

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385.0, 1050.0
21.0, 21.0

p22

p22

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

MO000000331 e28

MO000017272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c60 : 1
stoichiometry:c70 : 1

m290229*m28*0.1

nodelay

--

true

0

false

PMID: 11073096 Whatever the case, all appear to converge on a common pathway where the outcome will lead to the phosphorylation of phosphatidylinositol-4,5-bisphosphate (PIP2) by activated PI 3-kinase. As a result, phosphatidylinositol-3,4,5-triphosphate (PIP3) is generated

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389.0, 1114.0
21.0, 21.0

p22

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e32 MO000000331

MO000017272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m32*m290229*0.1

nodelay

--

true

0

false

PMID: 11073096 Whatever the case, all appear to converge on a common pathway where the outcome will lead to the phosphorylation of phosphatidylinositol-4,5-bisphosphate (PIP2) by activated PI 3-kinase. As a result, phosphatidylinositol-3,4,5-triphosphate (PIP3) is generated

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200.0, 613.0
23.0, 23.0

p24

p24

cso30:i:ME_Dimerization

cso30:i:CC_Cytoplasm

--

MO000000100

e9

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m89*0.1

nodelay

--

true

0

false

PMID: 11073096 Homodimers of cytokine (such as CSF-1) induce a rapid sequence of changes.

Go back
228.0, 669.0
23.0, 23.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e9 MO000007995

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m9*m1031*0.1

nodelay

--

true

0

false

PMID: 11073096 Ligand-induced covalent dimerization of receptor leads to autophosphorylation at a number of tyrosine residues on the cytoplasmic tail, which initiates signaling events that precede the rapid internalization and subsequent degradation of receptor-ligand complexes

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245.0, 734.0
21.0, 21.0

p26

p26

cso30:i:ME_Dimerization

cso30:i:CC_Extracellular

--

MO000007995 e27

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m1031*m27*0.1

nodelay

--

true

0

false

PMID: 11073096 Ligand-induced covalent dimerization of receptor leads to autophosphorylation at a number of tyrosine residues on the cytoplasmic tail, which initiates signaling events that precede the rapid internalization and subsequent degradation of receptor-ligand complexes

Go back
393.0, 766.0
21.0, 21.0

p27

p27

cso30:i:ME_Autophosphorylation

cso30:i:CC_Extracellular

--

e35

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 11073096 Ligand-induced covalent dimerization of receptor leads to autophosphorylation at a number of tyrosine residues on the cytoplasmic tail, which initiates signaling events that precede the rapid internalization and subsequent degradation of receptor-ligand complexes PMID: 11073096,8947469 Unlike serpentine receptors, receptor tyrosine kinases such as CSF-1R directly interact with a host of substrates after autophosphorylation induced by ligand binding, although in CSF-1-treated mouse macrophages, PI 3-kinase is the major protein associated with the activated receptor

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473.0, 634.0
21.0, 21.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e34 e38

MO000000030

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m34*m39*0.1

nodelay

--

true

0

false

PMID: 11073096 The p110 subunits in these PI 3-kinases exist in complex with a p85 protein that has two Src-homology-2 (SH2) domains

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478.0, 811.0
20.0, 20.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000030 e37

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m37*m38*0.1

nodelay

--

true

0

false

PMID: 11073096,10754559 The latter bind to phosphorylated tyrosine residues found on activated CSF-1R, thus allowing translocation to the plasma membrane where their lipid (such as PIP2) and other substrates are found

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666.0, 39.0
20.0, 20.0

p1

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 e10

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c7 : 1
stoichiometry:c11 : 1

m12*m10*0.1

nodelay

--

true

0

false

PMID: 11073096,10427991,9704038 Cells are responsive to bacterial components, leukotrienes, complement factors, and chemokines, an ever-expanding family of attractants controlling leukocyte migration. All these attractants in both neutrophils and monocytes/macrophages interact with specific serpentine (heptahelical) receptors [13 ], embedded in the plasma membrane, that transduce ligand-induced signals by coupling to heterotrimeric G proteins

Go back
382.0, 991.0
19.0, 19.0

p31

p31

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

MO000000331 e39

MO000017272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c90 : 1
stoichiometry:c94 : 1

m290229*m40*0.1

nodelay

--

true

0

false

PMID: 11073096 As was described for serpentine receptors, the net result of PI 3-kinase activation through receptor tyrosine kinases is the generation of PIP3 PMID: 11073096 Once again, recruitment to the plasma membrane of any of the p110 catalytic subunits results in the generation of PIP3

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394.0, 947.0
19.0, 19.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000012 e39

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c201 : 1
stoichiometry:c97 : 1

m42*m40*0.1

nodelay

--

true

0

false

PMID: 11073096,7737969 It was shown earlier that CSF-1R induces direct interaction of PI 3-kinase (via its p85 subunit) with the SH2/SH3 adaptor protein Grb2

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441.0, 1134.0
21.0, 21.0

p33

p33

cso30:i:ME_ADPRibosylation

cso30:i:CC_Extracellular

--

e42 e43 e46 e47

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c100 : 1

m44*m45*m48*m49*0.1

nodelay

--

true

0

false

PMID: 11073096,1643657 The most frequently used tool for studying Rho function is C3 transferase, an exoenzyme from Clostridium botulinum, which ADP-ribosylates and inactivates Rho

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444.0, 1085.0
23.0, 23.0

p34

p34

cso30:i:ME_UnknownInactivation

cso30:i:CC_Extracellular

--

e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 11073096,1643657 The most frequently used tool for studying Rho function is C3 transferase, an exoenzyme from Clostridium botulinum, which ADP-ribosylates and inactivates Rho

Go back
926.0, 371.0
19.0, 19.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000044 MO000017272

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m63*m157492*0.1

nodelay

--

true

0

false

PMID: 11073096,8990121 In the case of Vav, a GEF expressed only in hematopoietic cells, there is good evidence for this hypothesis because Vav is activated by tyrosine phosphorylation in response to extracellular signals, and binding of PIP3 enhances this phosphorylation PMID: 11073096,9268346 PIP3 binds to the PH domain of at least three GEFs, Tiam1, Sos, and the leukocyte-specific Vav

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993.0, 302.0
21.0, 21.0

p36

p36

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

MO000000044 e49 e48

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c109 : 1

m63*m65*m64*0.1

nodelay

--

true

0

false

PMID: 11073096,8990121 In the case of Vav, a GEF expressed only in hematopoietic cells, there is good evidence for this hypothesis because Vav is activated by tyrosine phosphorylation in response to extracellular signals, and binding of PIP3 enhances this phosphorylation

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629.0, 1070.0
21.0, 21.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e43 e64 MO000000021 MO000019600

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m45*m67*m68*m4142*0.1

nodelay

--

true

0

false

PMID:11073096,7888179,10081066 Finally, Rho, Rac, and Cdc42 have all been shown to complex with proteins known as GDIs (guanine nucleotide dissociation inhibitors), which prevent their interaction with other regulatory proteins and keep them sequestered in the cytoplasm

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729.0, 974.0
21.0, 21.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000021 MO000036321 MO000016577 MO000000166

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m68*m14748*m1574*m146*0.1

nodelay

--

true

0

false

PMID: 11073096,9490022 Of the three mammalian GDIs specific for the Rho family, only RhoGDI has a high affinity for RhoA, Rac1, and Cdc42

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769.0, 898.0
22.0, 22.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000036321 MO000035548 MO000023103 MO000023102

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m14748*m14041*m6915*m6914*0.1

nodelay

--

true

0

false

PMID: 11073096,8858161 In addition to keeping Rho family proteins in an inactive complex in the cytoplasm, RhoGDI interacts with ERM (ezrin/radixin/moesin) proteins, which in turn interact with transmembrane proteins such as CD44 and ICAM-1, and also with actin

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819.0, 48.0
17.0, 17.0

p1

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 e10

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c9 : 1
stoichiometry:c12 : 1

m14*m10*0.1

nodelay

--

true

0

false

PMID: 11073096,10427991,9704038 Cells are responsive to bacterial components, leukotrienes, complement factors, and chemokines, an ever-expanding family of attractants controlling leukocyte migration. All these attractants in both neutrophils and monocytes/macrophages interact with specific serpentine (heptahelical) receptors [13 ], embedded in the plasma membrane, that transduce ligand-induced signals by coupling to heterotrimeric G proteins

Go back
993.0, 914.0
22.0, 22.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e67 MO000002553

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m71*m399*0.1

nodelay

--

true

0

false

PMID: 11073096,8858161 In addition to keeping Rho family proteins in an inactive complex in the cytoplasm, RhoGDI interacts with ERM (ezrin/radixin/moesin) proteins, which in turn interact with transmembrane proteins such as CD44 and ICAM-1, and also with actin

Go back
997.0, 954.0
22.0, 22.0

p40

p41

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e67 MO000000306

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m71*m242*0.1

nodelay

--

true

0

false

PMID: 11073096,8858161 In addition to keeping Rho family proteins in an inactive complex in the cytoplasm, RhoGDI interacts with ERM (ezrin/radixin/moesin) proteins, which in turn interact with transmembrane proteins such as CD44 and ICAM-1, and also with actin

Go back
913.0, 806.0
22.0, 22.0

p40

p42

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e67 e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m71*m74*0.1

nodelay

--

true

0

false

PMID: 11073096,8858161 In addition to keeping Rho family proteins in an inactive complex in the cytoplasm, RhoGDI interacts with ERM (ezrin/radixin/moesin) proteins, which in turn interact with transmembrane proteins such as CD44 and ICAM-1, and also with actin

Go back
758.0, 735.0
19.0, 19.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017392 MO000023103 MO000023102 MO000035548

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m2225*m6915*m6914*m14041*0.1

nodelay

--

true

0

false

PMID: 11073096,9681826 ERM proteins can also bind to the Rho GEF, Dbl, suggesting that they may coordinate the release of Rho proteins from GDIs and enhance exchange of GDP for GTP

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606.0, 787.0
19.0, 19.0

p43

p44

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000105858 MO000035548 MO000023103 MO000023102

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m78700*m14041*m6915*m6914*0.1

nodelay

--

true

0

false

PMID: 11073096,9681826 ERM proteins can also bind to the Rho GEF, Dbl, suggesting that they may coordinate the release of Rho proteins from GDIs and enhance exchange of GDP for GTP

Go back
489.0, 918.0
21.0, 21.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e37 e64

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m38*m67*0.1

nodelay

--

true

0

false

PMID: 11073096,9099945 Rac is activated by a wide variety of tyrosine kinase receptors including the CSF-1R and serpentine receptors .

Go back
401.0, 1226.0
21.0, 21.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017272 e75

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m157492*m79*0.1

nodelay

--

true

0

false

PMID: 11073096,9268346 PIP3 binds to the PH domain of at least three GEFs, Tiam1, Sos, and the leukocyte-specific Vav

Go back
409.0, 1278.0
21.0, 21.0

p46

p47

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017272 MO000016777

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m157492*m1720*0.1

nodelay

--

true

0

false

PMID: 11073096,9268346 PIP3 binds to the PH domain of at least three GEFs, Tiam1, Sos, and the leukocyte-specific Vav

Go back
1257.0, 1202.0
21.0, 21.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000033474 MO000033467

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m138859*m12151*0.1

nodelay

--

true

0

false

PMID: 11073096,8810279 It should not be forgotten that many other possibilities exist. It has been shown that N-formyl-methionyl-leucyl-phenylalanine (fMLP) receptor stimulation will also cause activation of the src-related kinase, Lyn, directly indicating the involvement of tyrosine kinase activity leading to Rac and Cdc42 activation through serpentine receptor activation.

Go back
1109.0, 1202.0
21.0, 21.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e78 MO000000144

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m82*m128*0.1

nodelay

--

true

0

false

PMID: 11073096,8810279 It should not be forgotten that many other possibilities exist. It has been shown that N-formyl-methionyl-leucyl-phenylalanine (fMLP) receptor stimulation will also cause activation of the src-related kinase, Lyn, directly indicating the involvement of tyrosine kinase activity leading to Rac and Cdc42 activation through serpentine receptor activation.

Go back
389.0, 198.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 e17

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c18 : 1
stoichiometry:c16 : 1

m5*m17*0.1

nodelay

--

true

0

false

PMID: 11073096 In the GDP-bound form, the {alpha} subunit interacts with the ? and {gamma} subunits to form an inactive heterotrimer that binds to the serpentine receptor

Go back
605.0, 1122.0
21.0, 21.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e64 MO000017251

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m67*m2107*0.1

nodelay

--

true

0

false

PMID: 11073096,8756646 For example, IQGAP1, which is abundant in lamellipodia, binds to actin filaments and also to Rac and Cdc42

Go back
789.0, 1138.0
21.0, 21.0

p50

p51

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017251 MO000000021

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1

m2107*m68*0.1

nodelay

--

true

0

false

PMID: 11073096,8756646 For example, IQGAP1, which is abundant in lamellipodia, binds to actin filaments and also to Rac and Cdc42

Go back
793.0, 1082.0
22.0, 22.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000021 MO000036806

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m68*m15135*0.1

nodelay

--

true

0

false

PMID: 11073096,9210375 A Cdc42-interacting protein, CIP4, shows sequence homology to a small region of ERM proteins and may act as a transducer to the actin cytoskeleton

Go back
589.0, 1230.0
21.0, 21.0

p53

p53

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e83 e84

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m87*m88*0.1

nodelay

--

true

0

false

PMID: 11073096,10081063,9037011 In addition, Rho-kinase/ROK can induce the phosphorylation of myosin II light chain kinase, whereas the Rac/Cdc42-specific PAK family of kinases can phosphorylate myosin I heavy chain, although it is debatable whether this occurs in mammalian cells

Go back
725.0, 1186.0
21.0, 21.0

p53

p54

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e86 MO000018441

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m91*m3079*0.1

nodelay

--

true

0

false

PMID: 11073096,10081063,9037011 In addition, Rho-kinase/ROK can induce the phosphorylation of myosin II light chain kinase, whereas the Rac/Cdc42-specific PAK family of kinases can phosphorylate myosin I heavy chain, although it is debatable whether this occurs in mammalian cells

Go back
906.0, 1219.0
20.0, 20.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019591 MO000019590

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c177 : 1
stoichiometry:c178 : 1

m4135*m4134*0.1

nodelay

--

true

0

false

PMID: 11073096,9214622 Finally, the Rho target p140mDia can bind to profilin, an actin-binding protein with the potential to enhance actin polymerization at the leading edge of migrating cells.

Go back
873.0, 1046.0
21.0, 21.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000021 MO000017852 e20

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c182 : 1
stoichiometry:c181 : 1

m68*m2602*m20*0.1

nodelay

--

true

0

false

PMID: 11073096,8805223,8643625,8625410 Three groups have demonstrated that WASP interacts directly with Cdc42 in a GTP-dependent manner PMID: 11073096,9822597 Just carboxy-terminal to the EVH1 domain of WASP is the CRIB motif, which confers interaction with Cdc42, and more centrally there are proline-rich sequences that can interact with SH3-containing proteins such as the adaptor proteins Nck and Grb2, protein tyrosine kinases of the c-Src family such as Fyn, and the actin-binding protein profilin

Go back
917.0, 1038.0
21.0, 21.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017852 MO000000012

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m2602*m42*0.1

nodelay

--

true

0

false

PMID: 11073096,9822597 Just carboxy-terminal to the EVH1 domain of WASP is the CRIB motif, which confers interaction with Cdc42, and more centrally there are proline-rich sequences that can interact with SH3-containing proteins such as the adaptor proteins Nck and Grb2, protein tyrosine kinases of the c-Src family such as Fyn, and the actin-binding protein profilin

Go back
998.0, 1031.0
19.0, 19.0

p57

p58

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017852 e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c187 : 1
stoichiometry:c188 : 1

m2602*m96*0.1

nodelay

--

true

0

false

PMID: 11073096,9822597 Just carboxy-terminal to the EVH1 domain of WASP is the CRIB motif, which confers interaction with Cdc42, and more centrally there are proline-rich sequences that can interact with SH3-containing proteins such as the adaptor proteins Nck and Grb2, protein tyrosine kinases of the c-Src family such as Fyn, and the actin-binding protein profilin

Go back
1010.0, 1115.0
19.0, 19.0

p57

p59

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017852 MO000019591

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c190 : 1
stoichiometry:c191 : 1

m2602*m4135*0.1

nodelay

--

true

0

false

PMID: 11073096,9822597 Just carboxy-terminal to the EVH1 domain of WASP is the CRIB motif, which confers interaction with Cdc42, and more centrally there are proline-rich sequences that can interact with SH3-containing proteins such as the adaptor proteins Nck and Grb2, protein tyrosine kinases of the c-Src family such as Fyn, and the actin-binding protein profilin

Go back
433.0, 302.0
21.0, 21.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e16 MO000000315

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c17 : 1

m16*m250*0.1

nodelay

--

true

0

false

PMID: 11073096 Heterotrimeric G-proteins are made up of an {alpha}, beta, and {gamma} subunit, with the {alpha} subunit being the GDP/GTP binding module. PMID: 11073096 In the GDP-bound form, the {alpha} subunit interacts with the beta and {gamma} subunits to form an inactive heterotrimer that binds to the serpentine receptor

Go back
1081.0, 1046.0
21.0, 21.0

p57

p60

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017852 MO000000143

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c193 : 1
stoichiometry:c194 : 1

m2602*m127*0.1

nodelay

--

true

0

false

PMID: 11073096,9822597 Just carboxy-terminal to the EVH1 domain of WASP is the CRIB motif, which confers interaction with Cdc42, and more centrally there are proline-rich sequences that can interact with SH3-containing proteins such as the adaptor proteins Nck and Grb2, protein tyrosine kinases of the c-Src family such as Fyn, and the actin-binding protein profilin

Go back
990.0, 1271.0
20.0, 20.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017852 MO000019632

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1

m2602*m4169*0.1

nodelay

--

true

0

false

PMID: 11073096,9889097 The second is the A motif, which includes a cluster of acidic residues that mediate binding to the Arp2/3 complex

Go back
449.0, 770.0
21.0, 21.0

p62

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e5 e64

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c199 : 1
stoichiometry:c200 : 1

m5*m67*0.1

nodelay

--

true

0

false

PMID: 11073096,10224076 Rac is activated by a wide variety of tyrosine kinase receptors including the CSF-1R and serpentine receptors

Go back
516.0, 233.0
23.0, 23.0

p7

p7

cso30:i:ME_GDP-GTPExchange

cso30:i:CC_Cytoplasm

--

e20 e7

e16 e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c27 : 1
stoichiometry:c19 : 1

m20*m7*0.1

nodelay

--

true

0

false

PMID: 11073096 Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.

Go back
620.0, 233.0
23.0, 23.0

p7

p8

cso30:i:ME_GDP-GTPExchange

cso30:i:CC_Cytoplasm

--

e20 e11

e16 e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c22 : 1
stoichiometry:c21 : 1
stoichiometry:c23 : 1

m20*m11*0.1

nodelay

--

true

0

false

PMID: 11073096 Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.

Go back
684.0, 229.0
23.0, 23.0

p7

p9

cso30:i:ME_GDP-GTPExchange

cso30:i:CC_Cytoplasm

--

e13 e20

e16 e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c26 : 1
stoichiometry:c25 : 1
stoichiometry:c29 : 1

m13*m20*0.1

nodelay

--

true

0

false

PMID: 11073096 Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.

Go back
354.0, 57.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.0, 57.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
462.0, 1145.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
473.91478670167504, 1108.023148626429

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.6379617782631, 1067.974522228289

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
422.0, 1161.7639112242477

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
463.4708276965784, 1161.6341314207293

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
939.7620869714772, 340.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.0, 396.36881498276625

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.0, 374.74672566954445

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
960.0, 318.10493924633687

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.0, 318.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.0, 59.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1021.9989679583271, 309.0

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1009.0359463942372, 330.7365962981012

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
514.0, 1081.2780926979885

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
515.0, 1028.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
641.6379617782632, 995.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.0, 1033.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
650.0, 1086.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
658.0, 985.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
702.0, 956.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
754.0447410007557, 958.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
836.0, 59.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
756.1834263784746, 998.0759470271059

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
750.0, 987.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.0, 915.8941975532522

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.0, 874.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.0, 813.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.6568542494924, 841.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
791.0, 909.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
936.0, 911.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1023.0, 925.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1015.0, 888.5944732131918

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
462.0, 313.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
936.0, 917.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1027.0, 965.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1019.0, 969.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
924.0, 836.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
903.0, 835.0518397602302

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.0, 817.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
671.0, 750.2906988878473

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
771.5689290811055, 761.8446454055273

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
782.9006816948239, 758.4020325375149

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
719.0, 761.2570919756213

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 209.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
777.0, 745.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
563.0, 807.2541450602852

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
631.5158932948676, 807.6414582374399

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.9968720980183, 797.2236887300145

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.9331994522724, 799.0316716776498

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.8993262705642, 768.0496045501138

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.0, 873.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
500.0, 947.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
459.4920113466981, 939.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
352.0, 1177.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.0, 191.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
423.48247494163365, 1253.6262673050237

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
422.0, 1237.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
348.0, 1177.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
403.0, 1306.68

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.0, 1299.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1273.3947205962986, 1151.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1220.0, 1155.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1221.9913606886246, 1214.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1137.9914928787896, 1214.3688381328673

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1120.0, 1231.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
361.1214751973158, 162.14577023677901

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1069.3000400080607, 1221.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
510.0, 1031.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
633.3316266328584, 1140.2011327551918

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.9867755138251, 1143.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
719.0, 1153.9923283184849

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.0, 995.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
810.0, 1150.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
658.0, 992.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
778.0, 1051.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
815.0, 1094.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
418.65685424949237, 287.65685424949237

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
607.0364508500504, 1191.0

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
618.0, 1241.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
541.6564023547028, 1248.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
753.4043756496454, 1204.0290627657641

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
754.0, 1197.0

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
743.0, 1207.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
923.1513543886333, 1163.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.0, 1191.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
916.0, 1239.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
658.0, 988.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
398.0, 226.98228126285287

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.68253731564, 992.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.0, 1062.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
531.0, 193.0

c182

c182

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
925.0, 992.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
695.0, 896.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.0, 1052.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
935.0, 989.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.9975603804354, 971.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
974.2519285685115, 986.7765111560652

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
931.0, 992.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
363.22622003483434, 251.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
958.0, 1131.871832634471

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.8255305823146, 1134.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
935.0, 986.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1108.68564383761, 1067.3934230932866

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1089.3197443067909, 1067.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
927.0, 992.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1017.037652108609, 1289.8041362749238

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
975.3432448658572, 1291.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 228.0

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
463.2862142469185, 798.8959263491388

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.0, 69.70955211337804

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
541.0, 193.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.43074679772144, 791.0

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
352.0, 944.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.4754872673307, 256.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
494.0, 115.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
363.00075025331915, 252.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.456022239382, 136.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
589.9670707151171, 248.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
542.0, 190.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 256.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.0, 193.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
707.0, 159.55051879390047

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.5995641337032, 67.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
427.0, 134.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.0, 188.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
590.7554279005304, 248.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.897233121606, 114.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.0, 245.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.0, 335.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
522.0, 354.780571392251

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
522.0, 368.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.0, 405.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
490.0, 361.64782166760466

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.0, 54.83405311971232

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
490.0, 409.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
745.4251082046682, 161.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
663.4024411092854, 321.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.2690275348773, 327.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
816.7704729133137, 248.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
663.989267179309, 345.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
718.6045080093561, 351.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
563.3290170032623, 363.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
487.0, 489.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 500.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
538.0, 45.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.0, 1066.1411509102888

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
633.6465269501284, 363.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.0, 461.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
687.0, 473.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
642.0, 363.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
679.0, 484.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
712.0, 413.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
787.0, 431.23854961760793

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.0, 400.73544366254924

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
701.0, 428.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
498.1464137287468, 55.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.42469075791234, 575.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
639.5666828386379, 743.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
487.0, 497.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
655.7658681539207, 428.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.1476659023066, 640.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
415.0, 449.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.0, 464.36929755298485

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.3460102252582, 579.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
223.0, 625.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
252.28041664947477, 639.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.0, 54.121832049451854

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
350.78254163851676, 1071.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
414.2189607942333, 877.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
349.0, 1087.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
358.62871174953136, 1132.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
468.0, 458.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.0, 468.5490164590915

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
569.0, 670.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
259.0, 681.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
251.0, 688.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.4828028645824, 691.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
694.0, 49.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
274.0, 745.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.0, 752.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
355.0, 785.4246907579123

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
355.57434129350537, 787.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.0, 458.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.0, 645.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
494.0, 648.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
495.19787132923324, 678.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.0, 826.4577736509865

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
358.2179589656599, 829.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.0, 60.364968613913966

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.0, 955.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
345.0, 1016.428457546758

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.4013878696029, 1010.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.7750082841109, 892.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
354.36662955296686, 965.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
259.0, 1160.545499382968

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
466.05701381977434, 1096.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back