_enti_e1
_enti_e3
_enti_e2
_enti_e4
g1_fact_g1
g1_fact_g14
p1_propro_p1
PMID: 11073096,10427991,9704038
Cells are responsive to bacterial components, leukotrienes, complement factors, and chemokines, an ever-expanding family of attractants controlling leukocyte migration. All these attractants in both neutrophils and monocytes/macrophages interact with specific serpentine (heptahelical) receptors [13 ], embedded in the plasma membrane, that transduce ligand-induced signals by coupling to heterotrimeric G proteins
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p1_propro_p3
PMID: 11073096,10427991,9704038
Cells are responsive to bacterial components, leukotrienes, complement factors, and chemokines, an ever-expanding family of attractants controlling leukocyte migration. All these attractants in both neutrophils and monocytes/macrophages interact with specific serpentine (heptahelical) receptors [13 ], embedded in the plasma membrane, that transduce ligand-induced signals by coupling to heterotrimeric G proteins
c8 cso30:c:InputProcess connector
c7 cso30:c:InputProcess connector
c11 cso30:c:OutputProcess connector
p1_propro_p4
PMID: 11073096,10427991,9704038
Cells are responsive to bacterial components, leukotrienes, complement factors, and chemokines, an ever-expanding family of attractants controlling leukocyte migration. All these attractants in both neutrophils and monocytes/macrophages interact with specific serpentine (heptahelical) receptors [13 ], embedded in the plasma membrane, that transduce ligand-induced signals by coupling to heterotrimeric G proteins
c10 cso30:c:InputProcess connector
c9 cso30:c:InputProcess connector
c12 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 11073096
In the GDP-bound form, the {alpha} subunit interacts with the and {gamma} subunits to form an inactive heterotrimer that binds to the serpentine receptor
c14 cso30:c:InputProcess connector
c18 cso30:c:InputProcess connector
c16 cso30:c:OutputProcess connector
p1_propro_p2
PMID: 11073096,10427991,9704038
Cells are responsive to bacterial components, leukotrienes, complement factors, and chemokines, an ever-expanding family of attractants controlling leukocyte migration. All these attractants in both neutrophils and monocytes/macrophages interact with specific serpentine (heptahelical) receptors [13 ], embedded in the plasma membrane, that transduce ligand-induced signals by coupling to heterotrimeric G proteins
c5 cso30:c:InputProcess connector
c4 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 11073096
Heterotrimeric G-proteins are made up of an {alpha}, beta, and {gamma} subunit, with the {alpha} subunit being the GDP/GTP binding module.
PMID: 11073096
In the GDP-bound form, the {alpha} subunit interacts with the beta and {gamma} subunits to form an inactive heterotrimer that binds to the serpentine receptor
c13 cso30:c:InputProcess connector
c15 cso30:c:InputProcess connector
c17 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 11073096
Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.
c28 cso30:c:InputProcess connector
c30 cso30:c:InputProcess connector
c27 cso30:c:OutputProcess connector
c19 cso30:c:OutputProcess connector
p7_propro_p8
PMID: 11073096
Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.
c20 cso30:c:InputProcess connector
c22 cso30:c:InputProcess connector
c21 cso30:c:OutputProcess connector
c23 cso30:c:OutputProcess connector
p7_propro_p9
PMID: 11073096
Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.
c24 cso30:c:InputProcess connector
c26 cso30:c:InputProcess connector
c25 cso30:c:OutputProcess connector
c29 cso30:c:OutputProcess connector
p7_propro_p10
PMID: 11073096
Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.
c31 cso30:c:InputProcess connector
c33 cso30:c:InputProcess connector
c32 cso30:c:OutputProcess connector
c34 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 11073096
Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.
c35 cso30:c:InputProcess connector
c36 cso30:c:OutputProcess connector
c37 cso30:c:OutputProcess connector
p11_propro_p12
PMID: 11073096
Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.
c38 cso30:c:InputProcess connector
c39 cso30:c:OutputProcess connector
c40 cso30:c:OutputProcess connector
p11_propro_p13
PMID: 11073096
Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.
c41 cso30:c:InputProcess connector
c42 cso30:c:OutputProcess connector
c43 cso30:c:OutputProcess connector
p11_propro_p14
PMID: 11073096
Ligand (chemokine) binding to the receptor induces a conformational change that results in exchange of GDP for GTP on the {alpha} subunit, inducing its dissociation from both the receptor and the Gbeta{gamma} subunit.
c44 cso30:c:InputProcess connector
c45 cso30:c:OutputProcess connector
c46 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 11073096
The G protein complex dissociates into {alpha} and {gamma} subunits, which in turn bind and activate target enzymes such as phospholipase C, phosphoinositide 3-kinase (PI 3-kinase), or adenyl cyclase.
c47 cso30:c:InputProcess connector
c48 cso30:c:InputProcess connector
c49 cso30:c:OutputProcess connector
p15_propro_p16
PMID: 11073096
The G protein complex dissociates into {alpha} and {gamma} subunits, which in turn bind and activate target enzymes such as phospholipase C, phosphoinositide 3-kinase (PI 3-kinase), or adenyl cyclase.
c51 cso30:c:InputProcess connector
c75 cso30:c:InputProcess connector
c52 cso30:c:OutputProcess connector
p15_propro_p17
PMID: 11073096
The G protein complex dissociates into {alpha} and {gamma} subunits, which in turn bind and activate target enzymes such as phospholipase C, phosphoinositide 3-kinase (PI 3-kinase), or adenyl cyclase.
c53 cso30:c:InputProcess connector
c54 cso30:c:InputProcess connector
c55 cso30:c:OutputProcess connector
p15_propro_p18
PMID: 11073096
The G protein complex dissociates into {alpha} and {gamma} subunits, which in turn bind and activate target enzymes such as phospholipase C, phosphoinositide 3-kinase (PI 3-kinase), or adenyl cyclase.
c56 cso30:c:InputProcess connector
c57 cso30:c:InputProcess connector
c58 cso30:c:OutputProcess connector
p15_propro_p19
PMID: 11073096
The G protein complex dissociates into {alpha} and {gamma} subunits, which in turn bind and activate target enzymes such as phospholipase C, phosphoinositide 3-kinase (PI 3-kinase), or adenyl cyclase.
c59 cso30:c:InputProcess connector
c76 cso30:c:InputProcess connector
c61 cso30:c:OutputProcess connector
p15_propro_p20
PMID: 11073096
The G protein complex dissociates into {alpha} and {gamma} subunits, which in turn bind and activate target enzymes such as phospholipase C, phosphoinositide 3-kinase (PI 3-kinase), or adenyl cyclase.
c62 cso30:c:InputProcess connector
c63 cso30:c:InputProcess connector
c64 cso30:c:OutputProcess connector
p21_propro_p21
PMID:11073096,10579926
At least four Class I PI 3-kinase isoforms exist in mammalian cells, but only one form, a single Class IB variant containing the p110{gamma} catalytic subunit complexed with a 101-kDa regulatory protein, is thought to interact with G-proteins in leukocytes.
PMID:11073096
he free G{alpha} and G{gamma} subunits then interact with and modulate the activity of target proteins such as the Class 1B p101/p110{gamma} PI 3-kinase.
c65 cso30:c:InputProcess connector
c66 cso30:c:InputProcess connector
c74 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 11073096
Whatever the case, all appear to converge on a common pathway where the outcome will lead to the phosphorylation of phosphatidylinositol-4,5-bisphosphate (PIP2) by activated PI 3-kinase. As a result, phosphatidylinositol-3,4,5-triphosphate (PIP3) is generated
c50 cso30:c:InputProcess connector
c60 cso30:c:InputAssociation connector
c70 cso30:c:OutputProcess connector
p22_propro_p23
PMID: 11073096
Whatever the case, all appear to converge on a common pathway where the outcome will lead to the phosphorylation of phosphatidylinositol-4,5-bisphosphate (PIP2) by activated PI 3-kinase. As a result, phosphatidylinositol-3,4,5-triphosphate (PIP3) is generated
c71 cso30:c:InputAssociation connector
c72 cso30:c:InputProcess connector
c73 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 11073096
Homodimers of cytokine (such as CSF-1) induce a rapid sequence of changes.
c67 cso30:c:InputProcess connector
c68 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 11073096
Ligand-induced covalent dimerization of receptor leads to autophosphorylation at a number of tyrosine residues on the cytoplasmic tail, which initiates signaling events that precede the rapid internalization and subsequent degradation of receptor-ligand complexes
c69 cso30:c:InputProcess connector
c77 cso30:c:InputProcess connector
c78 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 11073096
Ligand-induced covalent dimerization of receptor leads to autophosphorylation at a number of tyrosine residues on the cytoplasmic tail, which initiates signaling events that precede the rapid internalization and subsequent degradation of receptor-ligand complexes
c79 cso30:c:InputProcess connector
c80 cso30:c:InputProcess connector
c81 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 11073096
Ligand-induced covalent dimerization of receptor leads to autophosphorylation at a number of tyrosine residues on the cytoplasmic tail, which initiates signaling events that precede the rapid internalization and subsequent degradation of receptor-ligand complexes
PMID: 11073096,8947469
Unlike serpentine receptors, receptor tyrosine kinases such as CSF-1R directly interact with a host of substrates after autophosphorylation induced by ligand binding, although in CSF-1-treated mouse macrophages, PI 3-kinase is the major protein associated with the activated receptor
c82 cso30:c:InputProcess connector
c83 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 11073096
The p110 subunits in these PI 3-kinases exist in complex with a p85 protein that has two Src-homology-2 (SH2) domains
c84 cso30:c:InputProcess connector
c85 cso30:c:InputProcess connector
c86 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 11073096,10754559
The latter bind to phosphorylated tyrosine residues found on activated CSF-1R, thus allowing translocation to the plasma membrane where their lipid (such as PIP2) and other substrates are found
c87 cso30:c:InputProcess connector
c88 cso30:c:InputProcess connector
c89 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 11073096
As was described for serpentine receptors, the net result of PI 3-kinase activation through receptor tyrosine kinases is the generation of PIP3
PMID: 11073096
Once again, recruitment to the plasma membrane of any of the p110 catalytic subunits results in the generation of PIP3
c93 cso30:c:InputProcess connector
c90 cso30:c:InputAssociation connector
c94 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 11073096,7737969
It was shown earlier that CSF-1R induces direct interaction of PI 3-kinase (via its p85 subunit) with the SH2/SH3 adaptor protein Grb2
c96 cso30:c:InputProcess connector
c201 cso30:c:InputProcess connector
c97 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 11073096,1643657
The most frequently used tool for studying Rho function is C3 transferase, an exoenzyme from Clostridium botulinum, which ADP-ribosylates and inactivates Rho
c98 cso30:c:InputAssociation connector
c99 cso30:c:InputProcess connector
c103 cso30:c:InputProcess connector
c104 cso30:c:InputProcess connector
c100 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 11073096,1643657
The most frequently used tool for studying Rho function is C3 transferase, an exoenzyme from Clostridium botulinum, which ADP-ribosylates and inactivates Rho
c101 cso30:c:InputProcess connector
c102 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 11073096,8990121
In the case of Vav, a GEF expressed only in hematopoietic cells, there is good evidence for this hypothesis because Vav is activated by tyrosine phosphorylation in response to extracellular signals, and binding of PIP3 enhances this phosphorylation
PMID: 11073096,9268346
PIP3 binds to the PH domain of at least three GEFs, Tiam1, Sos, and the leukocyte-specific Vav
c105 cso30:c:InputProcess connector
c106 cso30:c:InputProcess connector
c107 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 11073096,8990121
In the case of Vav, a GEF expressed only in hematopoietic cells, there is good evidence for this hypothesis because Vav is activated by tyrosine phosphorylation in response to extracellular signals, and binding of PIP3 enhances this phosphorylation
c108 cso30:c:InputProcess connector
c110 cso30:c:InputAssociation connector
c111 cso30:c:InputAssociation connector
c109 cso30:c:OutputProcess connector
p37_propro_p37
PMID:11073096,7888179,10081066
Finally, Rho, Rac, and Cdc42 have all been shown to complex with proteins known as GDIs (guanine nucleotide dissociation inhibitors), which prevent their interaction with other regulatory proteins and keep them sequestered in the cytoplasm
c112 cso30:c:InputProcess connector
c113 cso30:c:InputProcess connector
c114 cso30:c:InputProcess connector
c115 cso30:c:InputProcess connector
c116 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 11073096,9490022
Of the three mammalian GDIs specific for the Rho family, only RhoGDI has a high affinity for RhoA, Rac1, and Cdc42
c117 cso30:c:InputProcess connector
c118 cso30:c:InputProcess connector
c119 cso30:c:InputProcess connector
c120 cso30:c:InputProcess connector
c121 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 11073096,8858161
In addition to keeping Rho family proteins in an inactive complex in the cytoplasm, RhoGDI interacts with ERM (ezrin/radixin/moesin) proteins, which in turn interact with transmembrane proteins such as CD44 and ICAM-1, and also with actin
c122 cso30:c:InputProcess connector
c123 cso30:c:InputProcess connector
c124 cso30:c:InputProcess connector
c125 cso30:c:InputProcess connector
c126 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 11073096,8858161
In addition to keeping Rho family proteins in an inactive complex in the cytoplasm, RhoGDI interacts with ERM (ezrin/radixin/moesin) proteins, which in turn interact with transmembrane proteins such as CD44 and ICAM-1, and also with actin
c127 cso30:c:InputProcess connector
c128 cso30:c:InputProcess connector
c129 cso30:c:OutputProcess connector
p40_propro_p41
PMID: 11073096,8858161
In addition to keeping Rho family proteins in an inactive complex in the cytoplasm, RhoGDI interacts with ERM (ezrin/radixin/moesin) proteins, which in turn interact with transmembrane proteins such as CD44 and ICAM-1, and also with actin
c130 cso30:c:InputProcess connector
c131 cso30:c:InputProcess connector
c132 cso30:c:OutputProcess connector
p40_propro_p42
PMID: 11073096,8858161
In addition to keeping Rho family proteins in an inactive complex in the cytoplasm, RhoGDI interacts with ERM (ezrin/radixin/moesin) proteins, which in turn interact with transmembrane proteins such as CD44 and ICAM-1, and also with actin
c133 cso30:c:InputProcess connector
c134 cso30:c:InputProcess connector
c135 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 11073096,9681826
ERM proteins can also bind to the Rho GEF, Dbl, suggesting that they may coordinate the release of Rho proteins from GDIs and enhance exchange of GDP for GTP
c136 cso30:c:InputProcess connector
c137 cso30:c:InputProcess connector
c138 cso30:c:InputProcess connector
c139 cso30:c:InputProcess connector
c140 cso30:c:OutputProcess connector
p43_propro_p44
PMID: 11073096,9681826
ERM proteins can also bind to the Rho GEF, Dbl, suggesting that they may coordinate the release of Rho proteins from GDIs and enhance exchange of GDP for GTP
c141 cso30:c:InputProcess connector
c142 cso30:c:InputProcess connector
c143 cso30:c:InputProcess connector
c144 cso30:c:InputProcess connector
c145 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 11073096,9099945
Rac is activated by a wide variety of tyrosine kinase receptors including the CSF-1R and serpentine receptors .
c146 cso30:c:InputAssociation connector
c147 cso30:c:InputProcess connector
c148 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 11073096,9268346
PIP3 binds to the PH domain of at least three GEFs, Tiam1, Sos, and the leukocyte-specific Vav
c149 cso30:c:InputProcess connector
c150 cso30:c:InputProcess connector
c151 cso30:c:OutputProcess connector
p46_propro_p47
PMID: 11073096,9268346
PIP3 binds to the PH domain of at least three GEFs, Tiam1, Sos, and the leukocyte-specific Vav
c152 cso30:c:InputProcess connector
c153 cso30:c:InputProcess connector
c154 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 11073096,8810279
It should not be forgotten that many other possibilities exist. It has been shown that N-formyl-methionyl-leucyl-phenylalanine (fMLP) receptor stimulation will also cause activation of the src-related kinase, Lyn, directly indicating the involvement of tyrosine kinase activity leading to Rac and Cdc42 activation through serpentine receptor activation.
c155 cso30:c:InputProcess connector
c156 cso30:c:InputProcess connector
c157 cso30:c:OutputProcess connector
p49_propro_p49
PMID: 11073096,8810279
It should not be forgotten that many other possibilities exist. It has been shown that N-formyl-methionyl-leucyl-phenylalanine (fMLP) receptor stimulation will also cause activation of the src-related kinase, Lyn, directly indicating the involvement of tyrosine kinase activity leading to Rac and Cdc42 activation through serpentine receptor activation.
c158 cso30:c:InputAssociation connector
c159 cso30:c:InputProcess connector
c160 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 11073096,8756646
For example, IQGAP1, which is abundant in lamellipodia, binds to actin filaments and also to Rac and Cdc42
c161 cso30:c:InputProcess connector
c162 cso30:c:InputProcess connector
c163 cso30:c:OutputProcess connector
p50_propro_p51
PMID: 11073096,8756646
For example, IQGAP1, which is abundant in lamellipodia, binds to actin filaments and also to Rac and Cdc42
c164 cso30:c:InputProcess connector
c165 cso30:c:InputProcess connector
c166 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 11073096,9210375
A Cdc42-interacting protein, CIP4, shows sequence homology to a small region of ERM proteins and may act as a transducer to the actin cytoskeleton
c167 cso30:c:InputProcess connector
c168 cso30:c:InputProcess connector
c169 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 11073096,10081063,9037011
In addition, Rho-kinase/ROK can induce the phosphorylation of myosin II light chain kinase, whereas the Rac/Cdc42-specific PAK family of kinases can phosphorylate myosin I heavy chain, although it is debatable whether this occurs in mammalian cells
c170 cso30:c:InputAssociation connector
c171 cso30:c:InputProcess connector
c172 cso30:c:OutputProcess connector
p53_propro_p54
PMID: 11073096,10081063,9037011
In addition, Rho-kinase/ROK can induce the phosphorylation of myosin II light chain kinase, whereas the Rac/Cdc42-specific PAK family of kinases can phosphorylate myosin I heavy chain, although it is debatable whether this occurs in mammalian cells
c173 cso30:c:InputProcess connector
c174 cso30:c:InputAssociation connector
c175 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 11073096,9214622
Finally, the Rho target p140mDia can bind to profilin, an actin-binding protein with the potential to enhance actin polymerization at the leading edge of migrating cells.
c176 cso30:c:InputProcess connector
c177 cso30:c:InputProcess connector
c178 cso30:c:OutputProcess connector
p56_propro_p56
PMID: 11073096,8805223,8643625,8625410
Three groups have demonstrated that WASP interacts directly with Cdc42 in a GTP-dependent manner
PMID: 11073096,9822597
Just carboxy-terminal to the EVH1 domain of WASP is the CRIB motif, which confers interaction with Cdc42, and more centrally there are proline-rich sequences that can interact with SH3-containing proteins such as the adaptor proteins Nck and Grb2, protein tyrosine kinases of the c-Src family such as Fyn, and the actin-binding protein profilin
c179 cso30:c:InputProcess connector
c180 cso30:c:InputProcess connector
c182 cso30:c:InputAssociation connector
c181 cso30:c:OutputProcess connector
p57_propro_p57
PMID: 11073096,9822597
Just carboxy-terminal to the EVH1 domain of WASP is the CRIB motif, which confers interaction with Cdc42, and more centrally there are proline-rich sequences that can interact with SH3-containing proteins such as the adaptor proteins Nck and Grb2, protein tyrosine kinases of the c-Src family such as Fyn, and the actin-binding protein profilin
c183 cso30:c:InputProcess connector
c184 cso30:c:InputProcess connector
c185 cso30:c:OutputProcess connector
p57_propro_p58
PMID: 11073096,9822597
Just carboxy-terminal to the EVH1 domain of WASP is the CRIB motif, which confers interaction with Cdc42, and more centrally there are proline-rich sequences that can interact with SH3-containing proteins such as the adaptor proteins Nck and Grb2, protein tyrosine kinases of the c-Src family such as Fyn, and the actin-binding protein profilin
c186 cso30:c:InputProcess connector
c187 cso30:c:InputProcess connector
c188 cso30:c:OutputProcess connector
p57_propro_p59
PMID: 11073096,9822597
Just carboxy-terminal to the EVH1 domain of WASP is the CRIB motif, which confers interaction with Cdc42, and more centrally there are proline-rich sequences that can interact with SH3-containing proteins such as the adaptor proteins Nck and Grb2, protein tyrosine kinases of the c-Src family such as Fyn, and the actin-binding protein profilin
c189 cso30:c:InputProcess connector
c190 cso30:c:InputProcess connector
c191 cso30:c:OutputProcess connector
p57_propro_p60
PMID: 11073096,9822597
Just carboxy-terminal to the EVH1 domain of WASP is the CRIB motif, which confers interaction with Cdc42, and more centrally there are proline-rich sequences that can interact with SH3-containing proteins such as the adaptor proteins Nck and Grb2, protein tyrosine kinases of the c-Src family such as Fyn, and the actin-binding protein profilin
c192 cso30:c:InputProcess connector
c193 cso30:c:InputProcess connector
c194 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 11073096,9889097
The second is the A motif, which includes a cluster of acidic residues that mediate binding to the Arp2/3 complex
c195 cso30:c:InputProcess connector
c196 cso30:c:InputProcess connector
c197 cso30:c:OutputProcess connector
p62_propro_p62
PMID: 11073096,10224076
Rac is activated by a wide variety of tyrosine kinase receptors including the CSF-1R and serpentine receptors
c198 cso30:c:InputAssociation connector
c199 cso30:c:InputProcess connector
c200 cso30:c:OutputProcess connector
serpentine receptor_enti_e5
serpentine receptor
Bacterial component_enti_e6
Bacterial component
serpentine receptor:Bacterial component:Gproteins:GDP_enti_e7
serpentine receptor:Bacterial component:Gproteins:GDP
Leukotrines_enti_e8
Leukotrines
serpentine receptor: Leukotrines:G-proteins:GDP_enti_e11
serpentine receptor: Leukotrines:G-proteins:GDP
chemokines_enti_e12
chemokines
chemokines:serpentine receptor:G-proteins:GDP_enti_e13
chemokines:serpentine receptor:G-proteins:GDP
Complement factors_enti_e14
Complement factors
serpentine receptor:complement factors:G-proteins:GDP_enti_e15
serpentine receptor:complement factors:G-proteins:GDP
trimeric G-proteins(alpha+beta+gamma subunit)_enti_MO000000315
trimeric G-proteins(alpha+beta+gamma subunit)
serpentine receptor:trimeric G-proteins:GDP_enti_e10
serpentine receptor:trimeric G-proteins:GDP
GDP_enti_e16
GDP
Gproteins:GDP_enti_e17
Gproteins:GDP
GTP_enti_e20
GTP
serpentine receptor:Bacterial component:G-proteins:GTP_enti_e18
serpentine receptor:Bacterial component:G-proteins:GTP
serpentine receptor:Leukotrines:G-proteins:GTP_enti_e19
serpentine receptor:Leukotrines:G-proteins:GTP
serpentine receptor:chemokines:G-proteins:GTP_enti_e21
serpentine receptor:chemokines:G-proteins:GTP
serpentine receptor:complement factors:G-proteins:GTP_enti_e22
serpentine receptor:complement factors:G-proteins:GTP
Alpha subunit:GTP_enti_e23
Alpha subunit:GTP
Beta:Gamma subunit_enti_e24
Beta:Gamma subunit
PLC_enti_e25
PLC
Alpha subunit:GDP:PLC{active}_enti_e26
Alpha subunit:GDP:PLC{active}
Alpha subunit:GDP:PI 3-Kinase {active}_enti_e28
Alpha subunit:GDP:PI 3-Kinase {active}
adenyl cyclase_enti_e29
adenyl cyclase
Alpha subunit:GDP:Adenyl cyclase{active}_enti_e30
Alpha subunit:GDP:Adenyl cyclase{active}
Beta:Gammasubunit:adenyl cyclase{active}_enti_e31
Beta:Gammasubunit:adenyl cyclase{active}
Beta:Gammasubunit:PI 3 Kinase{active}_enti_e32
Beta:Gammasubunit:PI 3 Kinase{active}
Beta:Gammasubunit:PLC{active}_enti_e33
Beta:Gammasubunit:PLC{active}
p110 catalytic subunit_enti_e34
p110 catalytic subunit
101kDa Regulatory subunit_enti_e36
101kDa Regulatory subunit
PIP2_enti_MO000000331
PIP2
PIP3_enti_MO000017272
PIP3
PI3K_enti_MO000000030
PI3K
M-CSF-1-R_enti_MO000007995
M-CSF-1-R
M-CSF_enti_MO000000100
M-CSF
M-CSF(2)_enti_e9
M-CSF(2)
M-CSF(2):M-CSF-1-R_enti_e27
M-CSF(2):M-CSF-1-R
M-CSF(2):M-CSF-1-R(2)_enti_e35
M-CSF(2):M-CSF-1-R(2)
M-CSF(2):M-CSF-1-R(2){p}_enti_e37
M-CSF(2):M-CSF-1-R(2){p}
p85_enti_e38
p85
MCSF(2):M-CSF-1-R(2){p}:PI3K (p110:p85)_enti_e39
MCSF(2):M-CSF-1-R(2){p}:PI3K (p110:p85)
Grb-2_enti_MO000000012
Grb-2
MCSF(2):M-CSF-1-R (2) {p}:PI3K(p110:p85):Grb2_enti_e41
MCSF(2):M-CSF-1-R (2) {p}:PI3K(p110:p85):Grb2
C3 transferase_enti_e42
C3 transferase
Rho_enti_e43
Rho
Rho{inactive}_enti_e45
Rho{inactive}
ADP_enti_e46
ADP
Ribose_enti_e47
Ribose
Rho:ADP:Ribose_enti_e44
Rho:ADP:Ribose
Vav_enti_MO000000044
Vav
Vav:PIP3_enti_e48
Vav:PIP3
extracellular components_enti_e49
extracellular components
Vav{p}_enti_e63
Vav{p}
Rac_enti_e64
Rac
Cdc42_enti_MO000000021
Cdc42
Rho:Rac:Cdc42:GDIs_enti_e65
Rho:Rac:Cdc42:GDIs
GDIs_enti_MO000019600
GDIs
RhoGDI_enti_MO000036321
RhoGDI
RhoA_enti_MO000016577
RhoA
Rac1_enti_MO000000166
Rac1
RhoGDI:RhoA:Rac1:Cdc42_enti_e66
RhoGDI:RhoA:Rac1:Cdc42
radixin_enti_MO000035548
radixin
ezrin_enti_MO000023103
ezrin
moesin_enti_MO000023102
moesin
RhoGDI:ezrin:radixin:moesin_enti_e67
RhoGDI:ezrin:radixin:moesin
CD44_enti_MO000002553
CD44
ICAM-1_enti_MO000000306
ICAM-1
RhoGDI:RhoA:Rac1:moesin:CD44_enti_e68
RhoGDI:RhoA:Rac1:moesin:CD44
RhoGDI:RhoA:Rac1:moesin:ICAM-1_enti_e69
RhoGDI:RhoA:Rac1:moesin:ICAM-1
Actin_enti_e70
Actin
RhoGDI:RhoA:Rac1:moesin:actin_enti_e71
RhoGDI:RhoA:Rac1:moesin:actin
RhoGEF_enti_MO000017392
RhoGEF
RhoGEF:ezrin:moesin:radixin_enti_e72
RhoGEF:ezrin:moesin:radixin
DB1_enti_MO000105858
DB1
DB1:ezrin:moesin:radixin_enti_e73
DB1:ezrin:moesin:radixin
Rac{active}_enti_e74
Rac{active}
Tiam1_enti_e75
Tiam1
PIP3:Tiam1_enti_e76
PIP3:Tiam1
Sos_enti_MO000016777
Sos
PIP3:Sos_enti_e77
PIP3:Sos
fMLP_enti_MO000033474
fMLP
fMLP-R_enti_MO000033467
fMLP-R
fMLP:fMLP-R_enti_e78
fMLP:fMLP-R
Lyn_enti_MO000000144
Lyn
Lyn{active}_enti_e79
Lyn{active}
IQGAP1_enti_MO000017251
IQGAP1
IQGAP1:Rac_enti_e80
IQGAP1:Rac
IQGAP1:Cdc42_enti_e82
IQGAP1:Cdc42
CIP4_enti_MO000036806
CIP4
Cdc42:CIP4_enti_e81
Cdc42:CIP4
ROK_enti_e83
ROK
Mysosin II Light chain Kinase_enti_e84
Mysosin II Light chain Kinase
Mysosin II Light chain Kinase{p}_enti_e85
Mysosin II Light chain Kinase{p}
Myosin I heavy chain_enti_e86
Myosin I heavy chain
PAK_enti_MO000018441
PAK
Myosin I heavy chain{p}_enti_e87
Myosin I heavy chain{p}
mDia1_enti_MO000019590
mDia1
profilin_enti_MO000019591
profilin
mDia1:profilin_enti_e88
mDia1:profilin
WASP_enti_MO000017852
WASP
WASP:Cdc42_enti_e89
WASP:Cdc42
WASP:Grb2_enti_e90
WASP:Grb2
Nck_enti_e91
Nck
WASP:Nck_enti_e92
WASP:Nck
WASP:profilin_enti_e93
WASP:profilin
Fyn_enti_MO000000143
Fyn
Arp2/3 complex_enti_MO000019632
Arp2/3 complex
WASP:Fyn_enti_e94
WASP:Fyn
WASP:Arp2/3 complex_enti_e95
WASP:Arp2/3 complex