1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/11257452.csml convertedTime:2009.07.01.10:39

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title LPS induction of gene expression in human monocytes.
Authors Guha M, Mackman N.
Affiliation Departments of Immunology, C-204, The Scripps Research Institute, 10550 NorthTorrey Pines Road, La Jolla, CA 92037, USA.
Abstract Lipopolysaccharide (LPS [endotoxin]) is the principal component of the outermembrane of Gram-negative bacteria. Recent studies have elucidated how LPS isrecognized by monocytes and macrophages of the innate immune system. Humanmonocytes are exquisitely sensitive to LPS and respond by expressing manyinflammatory cytokines. LPS binds to LPS-binding protein (LBP) in plasma and isdelivered to the cell surface receptor CD14. Next, LPS is transferred to thetransmembrane signaling receptor toll-like receptor 4 (TLR4) and its accessoryprotein MD2. LPS stimulation of human monocytes activates several intracellularsignaling pathways that include the IkappaB kinase (IKK)-NF-kappaB pathway andthree mitogen-activated protein kinase (MAPK) pathways: extracellularsignal-regulated kinases (ERK) 1 and 2, c-Jun N-terminal kinase (JNK) and p38.These signaling pathways in turn activate a variety of transcription factorsthat include NF-kappaB (p50/p65) and AP-1 (c-Fos/c-Jun), which coordinate theinduction of many genes encoding inflammatory mediators.
PMID 11257452
Model Abstract

Entity

e1:LPS e10:TLR4:MD2 e100:CHOP e101:MEF2C e102:Sap1a e103:Sap1a{p} e104:CHOP{p} e105:MEF2C{p} e106:MNK1/2 e107:MAPKAPK2(MK2) e108:PRAK{p} e109:PRAK e11:MYD88 e110:MAPKAPK2(MK2){p} e111:MNK1/2{p} e112:SB203580 e113:Egr-1 e12:MYD88{active} e13:IRAK{active} e14:TRAF6{active} e15:IRAK e16:TRAF6 e17:TAB2 e18:TAK1 e19:TAB2:TAK1 e2: e20:MEKK1 e21:ECSIT e22:ECSIT:MEKK1 e23:IKK-beta e24:IKK-beta{p} e25:p50:p65:Ikappa-Balpha{p} e26:PD98059 e27:protein reminant of Ikappa-Balpha e28: e29:p50:p65 e3:LBP e30:p50:p65{p} e31:p50:p65{p} e32:PI3K{active} e33:PI3K e34:AKT e35:AKT{active} e36: e37:MEKK1/4{active} e38:MEKK1/4 e39:MKK4/7{active} e4:LPS:LBP e40:MKK4/7 e41:JNK e42:JNK{active} e43:c-fos{p}:c-jun{p} e44: e45:MSK1 e46: e47:PKR e48:PKR{active} e49:MKK3/6 e5:CD14 e50:MKK3/6{active} e51:p38 e52:p38{active} e53:c-jun:ATF2 e54:c-jun{p}:ATF2{p} e55:MSK1{active} e56:Ras e57:Ras{active} e58:c-Raf e59:c-Raf{active} e6:CD14:LPS e60:MEK1/2 e61:MEK1/2{active} e62:ERK1/2 e63:ERK1/2{active} e64:ELK1:SRF e65:ELK1{p}:SRF{p} e66:CREB:ATF1 e67:CREB{p}:ATF1{p} e68: e69: e7:MD2 e70: e71: e72: e73: e74: e75: e76: e77: e78: e79: e8:TLR4 e80: e81: e82: e83: e84: e85:p50:p65:Ikappa-Balpha e86:genistein e87:PKC¦Æ e88:PKC¦Æ{active} e89:p50:p65{p}:CBP e9:LPS: TLR4:MD2 e90:CBP e91:p53/56lyn e92:p58/64c-fgr e93:p53/64c-fgr{p} e94:p53/56lyn{p} e95:PKCbeta e96:PKCbeta{active} e97:unknown e98:U0126 e99:dexamethasone

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p7 p8 p9
Model Detail
1640.0, 188.84020185029442
95.57611438183348, 54.15979814970564

LPS

--

e1

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false false false

--

Go back
1387.5, 494.0
49.0, 60.0

TLR4:MD2

--

e10

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p3

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false
PubMed11257452

--

Go back
793.5, 1370.0
37.0, 60.0

CHOP

--

e100

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p49

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
793.5, 1306.0
37.0, 60.0

MEF2C

--

e101

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p47

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
793.5, 1434.0
37.0, 60.0

Sap1a

--

e102

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p48

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
921.5, 1430.0
37.0, 60.0

Sap1a{p}

--

e103

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
921.5, 1366.0
37.0, 60.0

CHOP{p}

--

e104

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
921.5, 1302.0
37.0, 60.0

MEF2C{p}

--

e105

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
793.5, 1518.0
37.0, 60.0

MNK1/2

--

e106

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p53

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
793.5, 1598.0
37.0, 60.0

MAPKAPK2(MK2)

--

e107

cso30:c:Protein

cso30:i:CC_Nucleolus

--

--

p54

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
541.5, 1714.0
37.0, 60.0

PRAK{p}

--

e108

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
793.5, 1670.0
37.0, 60.0

PRAK

--

e109

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p55

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
1030.0, 561.5
60.0, 45.0

MYD88

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false
PubMed11257452

--

Go back
541.5, 1642.0
37.0, 60.0

MAPKAPK2(MK2){p}

--

e110

cso30:c:Protein

cso30:i:CC_Nucleolus

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
541.5, 1562.0
37.0, 60.0

MNK1/2{p}

--

e111

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
174.0, 763.0
60.0, 34.0

SB203580

--

e112

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p26

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
886.0, 1532.0
60.0, 32.0

Egr-1

--

e113

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p59

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
818.0, 581.5
60.0, 45.0

MYD88{active}

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

p6

p7

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
835.0, 462.0
26.0, 60.0

IRAK{active}

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

p7

p8

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
802.0, 321.5
60.0, 37.0

TRAF6{active}

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

p8

p5 p9

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1051.0, 454.0
26.0, 60.0

IRAK

--

e15

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1022.0, 353.5
60.0, 37.0

TRAF6

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1033.5, 250.0
37.0, 60.0

TAB2

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1043.0, 158.0
26.0, 60.0

TAK1

--

e18

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p5

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
713.0, 198.0
54.0, 60.0

TAB2:TAK1

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
45.79754588977405, 176.55248932439426
1352.8518924120633, 1644.1936224446438

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
651.0, 426.0
26.0, 60.0

MEKK1

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
742.0, 521.5
60.0, 37.0

ECSIT

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
637.0, 590.0
54.0, 60.0

ECSIT:MEKK1

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
591.0, 686.0
26.0, 60.0

IKK-beta

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10 p40

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
795.0, 694.0
26.0, 60.0

IKK-beta{p}

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
777.0, 782.0
54.0, 60.0

p50:p65:Ikappa-Balpha{p}

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
534.0, 1295.0
60.0, 34.0

PD98059

--

e26

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p34 p37 p38

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
738.0, 859.0
60.0, 58.0

protein reminant of Ikappa-Balpha

--

e27

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
201.48169702704527, 1147.8722433903204
839.5386115321603, 636.6211159308099

--

e28

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false true false

--

Go back
501.0, 938.0
54.0, 60.0

p50:p65

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
1658.0, 20.5
60.0, 39.0

LBP

--

e3

cso30:c:Protein

cso30:i:CC_Extracellular

--

p2

p1

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false false false
Entrez Gene3929, 16803, 29469
PubMed11257452

--

Go back
701.0, 970.0
54.0, 60.0

p50:p65{p}

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
597.0, 1110.0
54.0, 60.0

p50:p65{p}

--

e31

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
895.0, 714.0
26.0, 60.0

PI3K{active}

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1071.0, 714.0
26.0, 60.0

PI3K

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1067.0, 830.0
26.0, 60.0

AKT

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
923.0, 830.0
26.0, 60.0

AKT{active}

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
188.59050913403752, 1137.7564417600634
865.3209873181769, 656.8527191913234

--

e36

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false true false

--

Go back
1108.0, 1052.0
26.0, 60.0

MEKK1/4{active}

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1292.0, 1076.0
26.0, 60.0

MEKK1/4

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p18

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1104.0, 1172.0
26.0, 60.0

MKK4/7{active}

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
1499.5, 30.0
49.0, 60.0

LPS:LBP

--

e4

cso30:c:Complex

cso30:i:CC_Extracellular

--

p1

p2

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false false false
PubMed11257452

--

Go back
1288.0, 1172.0
26.0, 60.0

MKK4/7

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p19

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1308.0, 1280.0
26.0, 60.0

JNK

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1128.0, 1304.0
26.0, 60.0

JNK{active}

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
535.5, 1410.0
49.0, 60.0

c-fos{p}:c-jun{p}

--

e43

cso30:c:Complex

cso30:i:CC_Nucleolus

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
691.5, 1410.0
49.0, 60.0

--

e44

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

--

p22

true true true true

csml-variable:Double

c-fos:c-jun

0

false

infinite

0

unit false false false

--

Go back
395.0, 1670.0
26.0, 60.0

MSK1

--

e45

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p21

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
188.59050913403752, 1137.7564417600634
865.3209873181769, 656.8527191913234

--

e46

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false true false

--

Go back
143.0, 222.0
26.0, 60.0

PKR

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p24

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
319.0, 226.0
26.0, 60.0

PKR{active}

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
139.0, 438.0
26.0, 60.0

MKK3/6

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p25

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1393.5, 158.0
37.0, 60.0

CD14

--

e5

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p2

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false
Entrez Gene929, 60350, 12475
PubMed11257452
UniProtP08571

--

Go back
311.0, 438.0
26.0, 60.0

MKK3/6{active}

--

e50

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
143.0, 626.0
26.0, 60.0

p38

--

e51

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p26

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false false false

--

Go back
147.0, 1262.0
26.0, 60.0

p38{active}

--

e52

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false false false

--

Go back
293.0, 1254.0
54.0, 60.0

c-jun:ATF2

--

e53

cso30:c:Complex

cso30:i:CC_NuclearChromosome

--

--

p27 p39

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false false false

--

Go back
389.0, 1114.0
54.0, 60.0

c-jun{p}:ATF2{p}

--

e54

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false false false

--

Go back
215.0, 1486.0
26.0, 60.0

MSK1{active}

--

e55

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false false false

--

Go back
413.5, 190.0
37.0, 60.0

Ras

--

e56

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p30

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false false false
PubMed11257452

--

Go back
577.5, 190.0
37.0, 60.0

Ras{active}

--

e57

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false false false

--

Go back
378.0, 353.5
60.0, 45.0

c-Raf

--

e58

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false false false

--

Go back
538.0, 309.5
60.0, 45.0

c-Raf{active}

--

e59

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false false false

--

Go back
1385.0, 246.0
54.0, 60.0

CD14:LPS

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p3

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false
PubMed11257452

--

Go back
383.0, 414.0
26.0, 60.0

MEK1/2

--

e60

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p32 p46

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false false false

--

Go back
571.0, 414.0
26.0, 60.0

MEK1/2{active}

--

e61

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false false false

--

Go back
379.0, 610.0
26.0, 60.0

ERK1/2

--

e62

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false false false

--

Go back
419.0, 710.0
26.0, 60.0

ERK1/2{active}

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false false false

--

Go back
397.0, 1026.0
54.0, 60.0

ELK1:SRF

--

e64

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

--

p34 p37 p38

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
597.0, 1026.0
54.0, 60.0

ELK1{p}:SRF{p}

--

e65

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
201.0, 1370.0
54.0, 60.0

CREB:ATF1

--

e66

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

--

p28 p56 p57 p58

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
381.0, 1378.0
54.0, 60.0

CREB{p}:ATF1{p}

--

e67

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
678.4556490683501, 1596.339448998359
153.08285622947253, 115.99452536027482

--

e68

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false true false

--

Go back
282.05162135834746, 1153.322896291245
505.9791248005719, 636.6211159308099

--

e69

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false true false

--

Go back
1469.5, 414.0
37.0, 60.0

MD2

--

e7

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false false false
Entrez Gene23643, 17087
PubMed11257452
TRANSPATHQ9Y6Y9

--

Go back
188.59050913403752, 1137.7564417600634
865.3209873181769, 656.8527191913234

--

e70

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false true false

--

Go back
392.5417970188648, 1429.6563625499862
27.403444212734403, 11.043858366622288

--

e71

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false true false

--

Go back
430.9750969566722, 1488.6337050444606
14.641257119164393, 12.25503220664424

--

e72

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false true false

--

Go back
391.6267184489168, 1396.720963494629
93.79555341964695, 141.31584013286647

--

e73

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false true false

--

Go back
201.48169702704527, 1147.8722433903204
839.5386115321603, 636.6211159308099

--

e74

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false true false

--

Go back
188.59050913403752, 1137.7564417600634
865.3209873181769, 656.8527191913234

--

e75

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false true false

--

Go back
820.2587158914398, 1407.5111519002364
54.06050077794968, 40.96292872323448

--

e76

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false true false

--

Go back
199.87029854041975, 1146.5234698396205
842.7614085054114, 639.3186630322116

--

e77

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false true false

--

Go back
40.75934778497512, 147.03296400312666
1410.2315109113022, 1672.5859237355648

--

e78

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false true false

--

Go back
59.232740835904856, 206.0720146456616
1346.6753814374117, 1622.6304350839234

--

e79

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false true false

--

Go back
1392.5, 354.0
38.86291739894552, 59.78910369068543

TLR4

--

e8

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p4

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false
Entrez Gene7099, 21898, 29260
PubMed11257452
UniProtO00206

--

Go back
21.86610489197876, 140.00015920743698
1438.0015477898328, 1747.6805755329574

--

e80

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false true false

--

Go back
103.83219311599916, 206.20018100792754
1274.0693713417925, 1615.2805319319762

--

e81

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false true false

--

Go back
21.86610489197876, 140.00015920743698
1438.0015477898328, 1747.6805755329574

--

e82

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false true false

--

Go back
50.62613584777533, 164.07289440761568
1380.4814858782404, 1699.5351051326015

--

e83

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false true false

--

Go back
35.72114968017607, 166.71264755063822
1393.8638539618248, 1641.2084405397309

--

e84

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false true false

--

Go back
473.0, 778.0
54.0, 60.0

p50:p65:Ikappa-Balpha

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
644.0, 1328.8402018502943
52.85954583683768, 29.95374264087469

genistein

--

e86

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p15

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1142.5, 952.0
37.0, 60.0

PKC¦Æ

--

e87

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p41

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
1314.5, 984.0
37.0, 60.0

PKC¦Æ{active}

--

e88

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
765.5, 1190.0
37.0, 60.0

p50:p65{p}:CBP

--

e89

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1386.5, 644.0
51.15177096714996, 71.3745641402092

LPS: TLR4:MD2

--

e9

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false
PubMed11257452

--

Go back
665.5, 1182.0
37.0, 60.0

CBP

--

e90

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p42

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
1138.0, 793.5
60.0, 37.0

p53/56lyn

--

e91

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p43

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
1146.0, 849.5
60.0, 37.0

p58/64c-fgr

--

e92

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p44

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
1286.0, 828.0
60.0, 48.0

p53/64c-fgr{p}

--

e93

cso30:c:Protein

cso30:i:CC_Cytosol

--

p44

--

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
1134.0, 724.0
60.0, 48.0

p53/56lyn{p}

--

e94

cso30:c:Protein

cso30:i:CC_Cytosol

--

p43

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1185.5, 422.0
37.0, 60.0

PKCbeta

--

e95

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p45

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
1185.5, 514.0
37.0, 60.0

PKCbeta{active}

--

e96

cso30:c:Protein

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
538.0, 570.0
60.0, 60.0

unknown

--

e97

cso30:c:ObjectUnknown

cso30:i:CC_Cytosol

--

--

p46

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
340.0, 520.8402018502944
95.57611438183348, 54.15979814970564

U0126

--

e98

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p32 p46

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
1200.0, 1372.8402018502943
95.57611438183348, 54.15979814970564

dexamethasone

--

e99

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p20

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1673.0, 105.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e3 e1

e4

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3*m1*0.1

nodelay

--

true

0

false

PubMed11257452

PMID: 11257452 LPS binds to the serum protein LBP and is transferred to the CD14 at the cell surface. PMID: 11257452 LPS and LPS-containing particles (including intact bacteria) form complexes with a plasma protein known as LPS-binding protein (LBP).

Go back
693.0, 725.0
30.0, 30.0

p10

p10

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c32 : 1
stoichiometry:c31 : 1

m23*m22*0.1

nodelay

--

true

0

false

PMID: 11257452 TAK1?TAB2 and MEKK1?ECSIT complexes phosphorylate IKK¦Â.

Go back
637.0, 793.0
30.0, 30.0

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m24*m84*0.1

nodelay

--

true

0

false

PMID: 11257452 IKK¦Â phosphorylates I¦ÊBs.

Go back
637.0, 873.0
30.0, 30.0

p12

p12

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m25*0.1

nodelay

--

true

0

false

--

Go back
637.0, 953.0
30.0, 30.0

p13

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c120 : 1
stoichiometry:c40 : 1

m29*m87*0.1

nodelay

--

true

0

false

PMID: 11257452 The PI3K?Akt pathway phosphorylates and activates p65 via an unknown kinase.

Go back
797.0, 957.0
30.0, 30.0

p14

p14

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 11257452 Degradation of I¦ÊBs permits nuclear translocation of NF-¦ÊB/Rel complexes, such as p50/p65.

Go back
709.0, 1265.0
30.0, 30.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e86 e89

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c44 : 1

m88*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines. The transcription factors that bind to these LPS response elements include NF-¦ÊB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS. PMID: 11257452, 78 The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.

Go back
993.0, 733.0
30.0, 30.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c47 : 1
stoichiometry:c46 : 1

m33*m9*0.1

nodelay

--

true

0

false

--

Go back
997.0, 845.0
30.0, 30.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c50 : 1
stoichiometry:c49 : 1

m34*m32*0.1

nodelay

--

true

0

false

--

Go back
1190.0, 1067.0
30.0, 30.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c53 : 1

m38*m9*0.1

nodelay

--

true

0

false

PMID: 11257452, 8610116 LPS stimulation of THP-1 cells and RAW 264.7 cells rapidly activates the JNK pathway. PMID: 11257452, 9891090, 10207617, 9096336 The MAPKKs, MKK4, and MKK7 are direct activators of JNK.

Go back
1186.0, 1187.0
30.0, 30.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1

m40*m37*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS stimulation of THP-1 cells and RAW 264.7 cells rapidly activates the JNK pathway. The MAPKKs, MKK4, and MKK7 are direct activators of JNK.

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1517.0, 221.0
30.0, 30.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true false true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
stoichiometry:c104 : 1

m4*m5*0.1

nodelay

--

true

0

false

PubMed11257452

PMID:11257452 LPS binds to the serum protein LBP and is transferred to the CD14 at the cell surface.

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1198.0, 1295.0
30.0, 30.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c138 : 1
stoichiometry:c59 : 1

m41*m39*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS stimulation of THP-1 cells and RAW 264.7 cells rapidly activates the JNK pathway. The MAPKKs, MKK4, and MKK7 are direct activators of JNK. PMID: 11257452, 9343388 The immunosuppressant dexamethasone reduced LPS-induced translation of TNF¦Á mRNA by selectively inhibiting the JNK pathway.

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293.0, 1613.0
30.0, 30.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c80 : 1

m44*m51*0.1

nodelay

--

true

0

false

PMID: 11257452, 9687510 p38 also phosphorylates numerous downstream kinases, including MNK1/2, MAPKAPK2 (MK2), MSK1, and PRAK, which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.

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617.0, 1425.0
30.0, 30.0

p22

p22

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleolus

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c63 : 1
stoichiometry:c62 : 1

c-fos:c-jun*m42*0.1

nodelay

--

true

0

false

PMID: 11257452 Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.

Go back
549.0, 1517.0
30.0, 30.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e43

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines. The transcription factors that bind to these LPS response elements include NF-¦ÊB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.

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229.0, 241.0
30.0, 30.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c107 : 1
stoichiometry:c68 : 1

m46*m9*0.1

nodelay

--

true

0

false

PMID: 11257452 MAPKKKs involved in the p38 signaling cascade include protein kinase RNA-regulated (PKR).

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217.0, 453.0
30.0, 30.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c72 : 1
stoichiometry:c71 : 1

m48*m47*0.1

nodelay

--

true

0

false

PMID: 11257452 The MAPKKs involved in p38 activation include the dual specificity kinases MKK3 and MKK6.

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225.0, 645.0
30.0, 30.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c139 : 1
stoichiometry:c170 : 1
stoichiometry:c74 : 1

m50*m49*m39*0.1

nodelay

--

true

0

false

PMID: 11257452 The MAPKKs involved in p38 activation include the dual specificity kinases MKK3 and MKK6. PMID: 11257452, 7839144 There is some evidence that MKK4 also phosphorylates the p38. PMID: 11257452, 7997261 One of these compounds, SB203580, specifically inhibited p38 activation and reduced LPS induction of IL-1 and TNFa expression without affecting the mRNA accumulation [149].

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261.0, 1169.0
30.0, 30.0

p27

p27

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c66 : 1
stoichiometry:c77 : 1

m52*m42*0.1

nodelay

--

true

0

false

PMID: 11257452 Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1. p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1.

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301.0, 1433.0
30.0, 30.0

p28

p28

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c102 : 1
stoichiometry:c101 : 1

m65*m54*0.1

nodelay

--

true

0

false

PMID: 11257452 p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.

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421.0, 1293.0
30.0, 30.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e54

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1

m53*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines. The transcription factors that bind to these LPS response elements include NF-¦ÊB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.

Go back
1645.0, 305.0
30.0, 30.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c105 : 1

m6*m10*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS binds to LPS-binding protein (LBP) in plasma and is delivered to the cell surface receptor CD14. Next, LPS is transferred to the transmembrane signaling receptor toll-like receptor 4 (TLR4) and its accessory protein MD2. PMID: 11257452 TLR4-MD2 complex functions as the LPS signaling receptor on the surface of monocytes. PMID: 11257452 LPS then interacts with the signaling receptor TLR4 and the accessory protein MD-2.

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497.0, 209.0
30.0, 30.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c106 : 1
stoichiometry:c83 : 1

m55*m9*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS activation of tyrosine kinases leads to activation of the MEK?ERK1/2 pathway in a Raf-1-dependent manner.

Go back
469.0, 313.0
30.0, 30.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c87 : 1
stoichiometry:c86 : 1

m57*m56*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS activation of tyrosine kinases leads to activation of the MEK?ERK1/2 pathway in a Raf-1-dependent manner.

Go back
469.0, 429.0
30.0, 30.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c90 : 1
stoichiometry:c136 : 1
stoichiometry:c89 : 1

m59*m58*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS activation of tyrosine kinases leads to activation of the MEK?ERK1/2 pathway in a Raf-1-dependent manner. PMID: 11257452, 99 Inhibition of MEK in monocytes by U0126 reduced LPS induction of several inflammatory cytokines, including IL-1, IL-8, and TNF¦Á, as well as prostaglandin E2.

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473.0, 625.0
30.0, 30.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c93 : 1
stoichiometry:c92 : 1

m61*m60*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS activation of tyrosine kinases leads to activation of the MEK?ERK1/2 pathway in a Raf-1-dependent manner.

Go back
489.0, 1041.0
30.0, 30.0

p34

p34

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c96 : 1
stoichiometry:c43 : 1
stoichiometry:c95 : 1

m63*m62*0.1

nodelay

--

true

0

false

PMID: 11257452 Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway. PMID: 11257452 Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1. PMID: 11257452, 10417144 PD98059 inhibited LPS induction of TNF¦Á in human monocytes. PMID: 11257452 PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes. PMID: 11257452 One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1.

Go back
613.0, 1265.0
30.0, 30.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e65

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines. The transcription factors that bind to these LPS response elements include NF-¦ÊB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.

Go back
393.0, 1513.0
30.0, 30.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e67

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines. The transcription factors that bind to these LPS response elements include NF-¦ÊB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.

Go back
489.0, 1097.0
30.0, 30.0

p37

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c98 : 1
stoichiometry:c115 : 1
stoichiometry:c84 : 1

m63*m51*0.1

nodelay

--

true

0

false

PMID: 11257452 Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway. PMID: 11257452 Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1. PMID: 11257452, 10417144 PD98059 inhibited LPS induction of TNF¦Á in human monocytes. PMID: 11257452 PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes. PMID: 11257452 One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1. PMID: 11257452, 8622669 p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1, CHOP, MEF2C, and Sap1a.

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489.0, 1145.0
30.0, 30.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c116 : 1
stoichiometry:c109 : 1

m63*m42*0.1

nodelay

--

true

0

false

PMID: 11257452 Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway. PMID: 11257452 Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1. PMID: 11257452, 10417144 PD98059 inhibited LPS induction of TNF¦Á in human monocytes. PMID: 11257452 PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes. PMID: 11257452 One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1.

Go back
313.0, 1125.0
30.0, 30.0

p27

p39

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c112 : 1
stoichiometry:c111 : 1

m52*m51*0.1

nodelay

--

true

0

false

PMID: 11257452 Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1. PMID: 11257452, 9422727 p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1.

Go back
1629.0, 425.0
30.0, 30.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c7 : 1
stoichiometry:c12 : 1

m7*m8*0.1

nodelay

--

true

0

false

PMID: 11257452 MD-2 physically associated with TLR4 in a similar manner to MD-1 binding to RP105.

Go back
709.0, 665.0
30.0, 30.0

p10

p40

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m19*m23*0.1

nodelay

--

true

0

false

PMID: 11257452 TAK1?TAB2 and MEKK1?ECSIT complexes phosphorylate IKK¦Â.

Go back
1218.0, 967.0
30.0, 30.0

p17

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c119 : 1
stoichiometry:c118 : 1

m86*m35*0.1

nodelay

--

true

0

false

PMID: 11257452, 9195953 PKC¦Æ is a downstream target of the LPS-activated PI3K-Akt pathway in human moncytic cells and may be involved in this process. However, the specific site(s) of phosphorylation of p65 was not identified.

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741.0, 1141.0
30.0, 30.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m89*m31*0.1

nodelay

--

true

0

false

PMID: 11257452, 9548485 The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.

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1225.0, 765.0
30.0, 30.0

p43

p43

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c128 : 1
stoichiometry:c125 : 1

m90*m9*0.1

nodelay

--

true

0

false

PMID: 11257452, 7691802, 8521300, 7519214 LPS stimulation of monocytes/macrophages induces the rapid tyrosine phosphorylation of proteins, including the src tyrosine kinase family members p53/56lyn, p58/64c-fgr.

Go back
1225.0, 841.0
30.0, 30.0

p43

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c129 : 1
stoichiometry:c127 : 1

m91*m9*0.1

nodelay

--

true

0

false

PMID: 11257452, 7691802, 8521300, 7519214 LPS stimulation of monocytes/macrophages induces the rapid tyrosine phosphorylation of proteins, including the src tyrosine kinase family members p53/56lyn, p58/64c-fgr.

Go back
1257.0, 485.0
30.0, 30.0

p6

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c132 : 1
stoichiometry:c131 : 1

m94*m9*0.1

nodelay

--

true

0

false

PMID: 11257452, 9195953, 7519214 LPS also activates typical (PKCbeta) and a typical (PKC¦Æ) isoforms of protein kinase C

Go back
477.0, 473.0
30.0, 30.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c135 : 1
stoichiometry:c137 : 1
stoichiometry:c134 : 1

m59*m96*0.1

nodelay

--

true

0

false

PMID: 11257452, 7799956, 8513862, 7477354 There is also evidence for LPS activation of the MEK-ERK1/2 pathway via c-Raf-independent pathways. PMID: 11257452, 9820549 Inhibition of MEK in monocytes by U0126 reduced LPS induction of several inflammatory cytokines, including IL-1, IL-8, and TNF¦Á, as well as prostaglandin E2.

Go back
857.0, 1317.0
30.0, 30.0

p38

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c146 : 1
stoichiometry:c141 : 1

m100*m51*0.1

nodelay

--

true

0

false

PMID: 11257452 Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway. PMID: 11257452 Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1. PMID: 11257452 PD98059 inhibited LPS induction of TNF¦Á in human monocytes. PMID: 11257452 PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes. PMID: 11257452 One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1. PMID: 11257452, 8621675 p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1, CHOP, MEF2C, and Sap1a.

Go back
851.0, 1449.0
30.0, 30.0

p38

p48

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c148 : 1
stoichiometry:c145 : 1

m101*m51*0.1

nodelay

--

true

0

false

PMID: 11257452 Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway. PMID: 11257452 Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1. PMID: 11257452 PD98059 inhibited LPS induction of TNF¦Á in human monocytes. PMID: 11257452 PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes. PMID: 11257452 One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1. PMID: 11257452, 9130707 p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1, CHOP, MEF2C, and Sap1a.

Go back
855.0, 1385.0
30.0, 30.0

p38

p49

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c147 : 1
stoichiometry:c143 : 1

m99*m51*0.1

nodelay

--

true

0

false

PMID: 11257452 Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway. PMID: 11257452 Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1. PMID: 11257452 PD98059 inhibited LPS induction of TNF¦Á in human monocytes. PMID: 11257452 PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes. PMID: 11257452 One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1. PMID: 11257452, 8650547 p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1, CHOP, MEF2C, and Sap1a.

Go back
897.0, 217.0
30.0, 30.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m18*m17*m14*0.1

nodelay

--

true

0

false

PMID: 11257452 Adaptor protein called TAB2 that mediates activation of TAK1 by linking TAK1 to TRAF6

Go back
985.0, 1313.0
30.0, 30.0

p15

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e105

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1

m104*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines. The transcription factors that bind to these LPS response elements include NF-¦ÊB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS. PMID: 11257452, 78 The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.

Go back
985.0, 1373.0
30.0, 30.0

p15

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1

m103*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines. The transcription factors that bind to these LPS response elements include NF-¦ÊB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS. PMID: 11257452, 78 The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.

Go back
981.0, 1441.0
30.0, 30.0

p15

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e103

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1

m102*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines. The transcription factors that bind to these LPS response elements include NF-¦ÊB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS. PMID: 11257452, 78 The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.

Go back
701.0, 1565.0
30.0, 30.0

p28

p53

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c158 : 1
stoichiometry:c153 : 1

m105*m51*0.1

nodelay

--

true

0

false

PMID: 11257452, 9155018 p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.

Go back
697.0, 1641.0
30.0, 30.0

p28

p54

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c159 : 1
stoichiometry:c155 : 1

m106*m51*0.1

nodelay

--

true

0

false

PMID: 11257452, 1327754 p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.

Go back
693.0, 1713.0
30.0, 30.0

p28

p55

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c160 : 1
stoichiometry:c157 : 1

m108*m51*0.1

nodelay

--

true

0

false

PMID: 11257452, 9628874 p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.

Go back
301.0, 1473.0
30.0, 30.0

p28

p56

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c164 : 1
stoichiometry:c165 : 1

m110*m65*0.1

nodelay

--

true

0

false

PMID: 11257452, 10391889 p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.

Go back
297.0, 1513.0
30.0, 30.0

p28

p57

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m109*m65*0.1

nodelay

--

true

0

false

PMID: 11257452, 10391889 p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.

Go back
293.0, 1557.0
30.0, 30.0

p28

p58

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m107*m65*0.1

nodelay

--

true

0

false

PMID: 11257452, 10391889 p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.

Go back
977.0, 1549.0
30.0, 30.0

p59

p59

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c171 : 1

m9*0.1

nodelay

--

true

0

false

--

Go back
941.0, 637.0
30.0, 30.0

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c14 : 1

m11*m9*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS activates the IKK pathway via MyD88, IRAK, and TRAF6.

Go back
937.0, 469.0
30.0, 30.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m15*m12*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS activates the IKK pathway via MyD88, IRAK, and TRAF6.

Go back
897.0, 369.0
30.0, 30.0

p8

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c21 : 1
stoichiometry:c20 : 1

m16*m13*0.1

nodelay

--

true

0

false

PMID: 11257452 LPS activates the IKK pathway via MyD88, IRAK, and TRAF6.

Go back
649.0, 525.0
30.0, 30.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c29 : 1
stoichiometry:c28 : 1

m20*m21*m14*0.1

nodelay

--

true

0

false

PMID: 11257452 a novel protein linking TRAF-6 to MEKK1 that was called evolutionarily conserved signaling intermediate in Toll pathways (ECSIT).

Go back
1688.0, 60.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1441.5403691564318, 335.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
255.0, 1415.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
331.0, 1423.221908914128

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
241.0, 1464.867452349257

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
408.0, 1438.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1544.0, 66.26210021209371

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1438.0606493387102, 201.76128048884564

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.1387387722042, 235.61087368128935

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
266.51873654071034, 263.732874097244

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
447.0, 1086.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.0, 1084.2570816034595

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1507.0, 440.19666186209093

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
526.7184029699328, 1166.1038668193905

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
343.0, 1141.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
173.0, 1159.3517178529796

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
617.0, 686.3292929262616

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
739.0, 688.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
510.14101437909676, 1130.833808313765

c115

c115

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
511.45876759286716, 1178.724513003065

c116

c116

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
683.0, 1298.0877209424682

c117

c117

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1248.0, 987.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
949.0, 865.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1444.5160588539031, 445.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
674.9816212176174, 969.5419619345296

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
703.0, 1172.9571543086322

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
651.0, 1143.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
762.0, 1171.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1198.0, 789.2491077284276

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1201.3775550546281, 763.0938134100054

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1206.0, 860.247700587784

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1255.0, 853.5150582239837

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1261.9329796549935, 695.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1260.592941055391, 706.0

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
977.7257215188587, 604.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1223.0, 465.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1229.716561257217, 510.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1288.9214425886476, 521.30709147283

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
409.0, 450.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
507.0, 453.4874276298162

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
506.5280520215392, 509.59520620528536

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
413.0, 461.94467046840373

c136

c136

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
435.0, 498.98455575342734

c137

c137

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1220.4044937663537, 1328.7453167102763

c138

c138

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
261.8041699352446, 673.2075255783315

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
885.3104923889621, 620.2491077284276

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.0, 1333.6135719910778

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
887.0, 1332.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.0, 1400.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
885.0, 1397.43180206412

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.0, 1464.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
881.0, 1461.3897804297073

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
173.0, 1293.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
173.0, 1294.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
173.0, 1295.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
959.0, 1329.6135719910778

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
978.985592821607, 653.4799034147601

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
959.0, 1390.916992863881

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
959.0, 1457.7242859683402

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
738.5894663844041, 1554.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.9732601698585, 1581.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
734.6965114603821, 1633.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.958950698325, 1658.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.7280699745334, 1705.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.9560436233712, 1730.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
173.0, 1299.0

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
173.0, 1301.0

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
975.0, 484.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
173.0, 1302.0

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
329.6142883137262, 1586.5001322317132

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
333.93002124067414, 1540.9968494597376

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
338.3585609892415, 1497.138722696833

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
255.0, 1427.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
331.0, 1436.2850231591362

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
248.0, 1430.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
324.0, 1444.2469504755443

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
242.0, 1430.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
317.0, 1444.819162328241

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
868.9751851892278, 485.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
209.0, 678.8360708322356

c170

c170

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
953.8035280165417, 1555.7620869714772

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1002.4313939835517, 715.0

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
868.0, 505.07921996143256

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
934.9717843273966, 375.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1688.0, 143.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
869.0308274533255, 360.81673490323385

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
861.0, 405.88548078943586

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
934.6589662697542, 192.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
934.5607282892591, 239.61445744581857

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
846.0, 253.45123996684563

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
774.9978706729183, 229.18456624629812

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
664.0, 486.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
687.0, 540.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
664.0, 555.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
682.1359984279131, 359.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1556.5201165001058, 71.7290745363287

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
617.0, 719.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.0, 727.3151918984429

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.0, 650.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
527.0, 808.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.0, 808.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
674.1554175279994, 825.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
674.0420014782096, 731.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
561.7187586831122, 898.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
667.0, 888.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.0, 968.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1525.0, 90.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.0, 974.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.0, 979.5298221281347

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.9544580660639, 985.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.9045188287974, 1074.8963888009735

c43

c43

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
744.7625617079318, 1239.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1030.9930645847387, 745.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
928.9930645847388, 744.3330443576974

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1030.889976596569, 684.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1035.0, 860.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
957.0, 860.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1431.0, 195.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
921.0, 758.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1180.0, 982.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1227.7859168143195, 1087.8383414700477

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1142.0, 1082.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1216.658327404353, 715.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1224.0, 1202.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1138.0, 1202.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1134.0, 1101.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1236.0, 1310.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1161.5720815054283, 1315.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1446.5894663844042, 241.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1130.0, 1217.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
655.0, 1440.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
593.0, 1440.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.8325200467996, 1337.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
420.0, 1174.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
562.0, 1470.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.8825909118575, 1188.365562344348

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
169.0, 253.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
259.0, 256.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.0, 1075.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1431.0, 389.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
165.0, 468.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
247.0, 468.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
242.4228514452495, 284.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
169.0, 657.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
165.00059831548856, 675.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
250.19345761862482, 498.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
286.1995556481267, 1206.332315026957

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
291.0, 1154.197769023179

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
725.2750216170905, 258.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
329.4854338271991, 1643.6839244307548

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1439.0, 281.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
245.62643064465016, 1540.5265718022742

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
173.0, 1322.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
451.0, 221.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.0, 221.31348453356284

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
519.0, 1072.352465419694

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
438.0, 341.33701495857673

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
499.0, 329.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.765261990441, 238.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
409.0, 444.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
499.0, 444.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1437.0, 337.0981148783624

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
499.8275413614843, 355.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
405.0, 640.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.93275494430594, 655.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
498.5219903405881, 470.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
451.0, 1056.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.0, 1056.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
439.0, 770.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
625.0, 1086.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
173.0, 1123.702828684458

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
322.0, 1162.9898164372275

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back