1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/11790540.csml convertedTime:2009.07.01.10:39

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The interferon-alpha/beta system in antiviral responses: a multimodal machineryof gene regulation by the IRF family of transcription factors.
Authors Taniguchi T, Takaoka A.
Affiliation Department of Immunology, Faculty of Medicine and Graduate School of Medicine,University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-0033, Tokyo, Japan.tada@m.u-tokyo.ac.jp
Abstract The efficient induction of interferons alpha and beta (IFN-alpha/beta) invirus-infected cells is central to the antiviral response of a host and isregulated mainly at the level of gene transcription. Once produced,IFN-alpha/beta transmit signals to the cell interior via a specific receptorcomplex to induce an antiviral response. Recently, the auto-amplificationmechanism of the IFN-alpha/beta system that follows viral infection has beenidentified. This mechanism is mediated by transcription factors of the IFNregulatory factor family and, in fact, may have evolved to render the systemmore robust in antiviral responses.
PMID 11790540
Model Abstract

Entity

G010199:OAS G010214:c-fos G010228:IFN-beta G010384:IRF-1 G010514:iNOS G010713:IRF-7 MO000000058:NF-kappaB MO000000279:c-Fos MO000007685:IRF-1 MO000007694:IRF-3 MO000007702:IRF-7 MO000013119:STAT1 MO000013120:STAT2 MO000016660:IFNbeta MO000016882:LPS MO000018626:RANK MO000018743:RANKL MO000022224:dsRNA MO000038482:IFNalpha, IFNbeta MO000041456:IRF-3{p} MO000041457:IRF-7{p} e1: e10: e11:unmethylated DNA e12:IRF-9 e13:ISGF3 e14:IFNAR1: IFNAR2: Jak1: Tyk2 e15:IFNAR1: IFNAR2: Jak1: Tyk2: IFNalpha,IFNbeta e16:AAF e17:IFNAR1: IFNAR2: Jak1{activated}: Tyk2 {activated}: IFNalpha,IFNbeta e18:AAf: GAs e19:GAS e2: e20:ISRE e21:ISGF3: ISRE e22:IRF-1: ISRE e23:IRF-3{p} e24:p300:CBP e25:DRAF1 e26:IRF-7: IRF-7 {p} e27:IRF-3{p}: IRF-7{p} e28:Isg15 e29:IP-10 e3: e30:PKR e31:RANK:RANKL e32:ISGF3 {nucleus} e4: e5:IFN-alpha e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:AAF {nucleus} e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p5 p6 p7 p8 p9
Model Detail
579.0, 1079.0
26.0, 26.0

OAS

--

G010199

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p29

--

true true true true

csml-variable:Double

m93189

10

false

infinite

0

unit false false false
TRANSFACG010199

--

Go back
643.0, 1127.0
26.0, 26.0

c-fos

--

G010214

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m93203

10

false

infinite

0

unit false false false
TRANSFACG010214

--

Go back
427.0, 1087.0
25.5, 25.5

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
481.0, 905.0
30.0, 30.0

IRF-1

--

G010384

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p6

--

true true true true

csml-variable:Double

m93359

10

false

infinite

0

unit false false false
TRANSFACG010384

--

Go back
673.0, 1057.0
22.0, 22.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p10

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
660.0, 1016.0
24.0, 24.0

IRF-7

--

G010713

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p8

--

true true true true

csml-variable:Double

m93631

10

false

infinite

0

unit false false false
TRANSFACG010713

--

Go back
194.0, 1062.0
36.0, 36.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
722.0, 1206.0
28.0, 28.0

c-Fos

--

MO000000279

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m221

10

false

infinite

0

unit false false false
InterProIPR002114
TRANSPATHMO000000279

--

Go back
754.0, 978.0
28.0, 28.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
255.0, 443.0
34.0, 34.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p14

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
235.0, 559.0
26.0, 26.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p17

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
650.0, 298.0
28.0, 28.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p4

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
651.0, 343.0
26.0, 26.0

STAT2

--

MO000013120

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m1358

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013120

--

Go back
651.0, 1231.0
25.0, 25.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
47.0, 563.0
26.0, 26.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p17

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
919.0, 1047.0
26.0, 26.0

RANK

--

MO000018626

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m3258

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000018626

--

Go back
1000.0, 1044.0
31.0, 31.0

RANKL

--

MO000018743

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m3373

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000018743

--

Go back
45.0, 505.0
30.0, 30.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p12

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1035.0, 155.0
25.0, 25.0

IFNalpha, IFNbeta

--

MO000038482

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m16692

10

false

infinite

0

unit false false false
TRANSPATHMO000038482

--

Go back
260.0, 500.0
32.0, 32.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
238.0, 614.0
28.0, 28.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
112.75, 83.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
121.0, 103.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
497.0, 1355.5
46.6369710467706, 16.32293986636971

unmethylated DNA

--

e11

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p23 p24

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
649.0, 381.0
30.0, 30.0

IRF-9

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
Affymetrix103634_at
EnsemblENSMUSG00000002325
InterProIPR008984
MGDMGI:107587
ProteomeHumanPSD/Isgf3g
RefSeqNM_008394
TRANSFACT05096
TRANSPATHMO000031278
UnigeneMm.2032
UniProtQ61179

--

Go back
835.0, 411.0
34.0, 34.0

ISGF3

--

e13

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
TRANSPATHMO000033508

--

Go back
924.5, 163.0
30.594788034501736, 42.69040190860708

IFNAR1: IFNAR2: Jak1: Tyk2

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
925.5, 228.0
29.040190860708382, 40.52119654982565

IFNAR1: IFNAR2: Jak1: Tyk2: IFNalpha,IFNbeta

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p2

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
805.0, 357.5
38.88, 29.159999999999997

AAF

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
925.5, 284.0
29.040190860708382, 40.52119654982565

IFNAR1: IFNAR2: Jak1{activated}: Tyk2 {activated}: IFNalpha,IFNbeta

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p3 p4

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
441.5, 865.625
45.0, 12.75

AAf: GAs

--

e18

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p5

p6

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
445.5, 823.125
45.0, 9.75

GAS

--

e19

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p5

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
112.75, 83.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
701.5, 880.125
36.99257097373308, 8.015057044308834

ISRE

--

e20

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p7 p9

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
649.5, 925.625
45.0, 12.75

ISGF3: ISRE

--

e21

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
705.5, 1005.625
45.0, 12.75

IRF-1: ISRE

--

e22

cso30:c:Complex

cso30:i:CC_NuclearBody

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
366.0, 878.0
28.0, 28.0

IRF-3{p}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
398.0, 914.0
36.0, 36.0

p300:CBP

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000041382

--

Go back
328.875, 967.5
29.74054872453661, 41.498440080748765

DRAF1

--

e25

cso30:c:Complex

cso30:i:CC_NuclearChromosome

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
234.62, 1155.125
33.96, 25.469999999999995

IRF-7: IRF-7 {p}

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
287.5, 1188.125
32.2, 24.15

IRF-3{p}: IRF-7{p}

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
489.0, 1005.0
30.0, 30.0

Isg15

--

e28

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p25 p27

--

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
Affymetrix4950
MGDG1p2
ProteomeHumanPSD/Isg15
RefSeqNM_015783
TRANSFACG043147
UnigeneMm.451527

--

Go back
533.0, 1053.0
30.0, 30.0

IP-10

--

e29

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p26 p28

--

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
Affymetrix1418930_at
EnsemblENSMUSG00000034855
MGDCxcl10
ProteomeHumanPSD/Cxcl10
RefSeqNM_021274
TRANSFACG001062
UnigeneMm.263514

--

Go back
129.87518862352903, 101.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
615.0, 1075.0
25.0, 25.0

PKR

--

e30

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p30

--

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
Affymetrix116778_at
EnsemblENSMUSG00000024079
MGDEif2ak2
ProteomeHumanPSD/Eif2ak2
RefSeqNM_011163
TRANSFACG001168
UnigeneMm.378990

--

Go back
916.0, 1100.0
31.0, 31.0

RANK:RANKL

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000053053

--

Go back
631.0, 811.0
34.0, 34.0

ISGF3 {nucleus}

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000033508

--

Go back
161.55678757705792, 131.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
525.0, 1133.0
30.0, 30.0

IFN-alpha

--

e5

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p19 p22 p24 p31

--

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHG016992

--

Go back
299.0, 779.0
496.8244732065042, 450.5652112692136

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
352.6607438472573, 789.6777404882927
290.5081649661869, 436.68743268802626

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
305.4762966712207, 785.0137040518478
483.87187986406303, 438.5378031655178

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
306.40148190996655, 785.9388892905936
482.0215093865711, 436.68743268802626

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
299.0, 779.0
496.8244732065042, 450.5652112692136

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
299.0, 779.0
496.8244732065042, 450.5652112692136

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
306.40148190996655, 785.9388892905936
482.0215093865711, 436.68743268802626

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
661.6726135883605, 964.0370477491638
31.038863281850354, 28.098339391990876

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
580.2563125787285, 1093.562981173578
87.89259768085269, 79.56593053214043

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
299.0, 779.0
496.8244732065042, 450.5652112692136

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
541.0, 809.5
38.88, 29.159999999999997

AAF {nucleus}

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
416.09873289587654, 979.2274568370484
15.733701059569356, 7.575485695348216

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
415.573340081973, 956.6355658391972
53.852763425110325, 96.93497416519858

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
438.1652310798247, 1019.6827035076192
8.406285022456238, 8.406285022456242

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
124.0, 89.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
127.0, 110.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
135.0, 131.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1036.0, 236.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m15*m16692*0.1

nodelay

--

true

0

false

PMID: 11790540, 11355893 In turn, virally induced IFN-alpha/beta activates Jak protein tyrosine kinases (Jak1 and Tyk2), leading to formation of both the ISGF3 transcriptional complex and AAF: the former activates several IFN-inducible genes including IRF-7 [39], whereas the latter mediates activation of the IRF-1 gene by its binding to GAS (IFN-gamma-activated site).

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715.0, 1055.0
25.0, 25.0

p10

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 11790540 IRF-1 in turn induces genes such as that for iNOS.

Go back
328.0, 1036.0
23.0, 23.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c40 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 11790540, 9707562, 9566918, 9541017 This phosphorylated IRF-3 then undergoes nuclear translocation, interacts with coactivators CBP and p300, and primarily activates the IFN-beta promoter. PMID: 11790540, 3805784, 6802744 In this context, it is interesting to note that IFN-alpha/beta are also induced by nonviral, pathogen-associated molecules, such as lipopolysaccharide (LPS) and unmethylated DNA.

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190.0, 562.0
25.0, 25.0

p12

p12

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c46 : 1
stoichiometry:c43 : 1

m980*m119368*0.1

nodelay

--

true

0

false

PMID: 11790540, 9822609, 9877175, 9786932 Subsequently the de novo produced IRF-7 undergoes virus-induced phosphorylation, similar to IRF-3, and activates the IFN-alpha/beta promoters.

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200.0, 504.0
23.0, 23.0

p13

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m155666*m977*0.1

nodelay

--

true

0

false

PMID: 11790540, 7559546, 9488451 Briefly, viral infections result in phosphorylation of the constitutively expressed IRF-3 at its carboxy-terminal region, converting it to its active form. PMID: 11790540, 3805784, 6802744 In this context, it is interesting to note that IFN-alpha/beta are also induced by nonviral, pathogen-associated molecules, such as lipopolysaccharide (LPS) and unmethylated DNA.

Go back
201.0, 449.0
23.0, 23.0

p14

p14

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c34 : 1
stoichiometry:c33 : 1

m977*m119368*0.1

nodelay

--

true

0

false

PMID: 11790540, 7559546, 9488451 Briefly, viral infections result in phosphorylation of the constitutively expressed IRF-3 at its carboxy-terminal region, converting it to its active form. PMID: 11790540, 7559546, 9488451 In fact, IRF-3 interacts with the CREB-binding protein (CBP)/p300 coativators, forming a complex, termed double-stranded RNA-activated factor 1 (DRAF1), for some IFN-inducible genes.

Go back
263.0, 879.0
25.0, 25.0

p15

p15

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 11790540, 9707562, 9566918, 9541017 This phosphorylated IRF-3 then undergoes nuclear translocation, interacts with coactivators CBP and p300, and primarily activates the IFN-beta promoter.

Go back
332.0, 920.0
23.0, 23.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m24*m25*0.1

nodelay

--

true

0

false

PMID: 11790540, 9707562, 9566918, 9541017 This phosphorylated IRF-3 then undergoes nuclear translocation, interacts with coactivators CBP and p300, and primarily activates the IFN-beta promoter. PMID: 11790540, 7559546, 9488451 In fact, IRF-3 interacts with the CREB-binding protein (CBP)/p300 coativators, forming a complex, termed double-stranded RNA-activated factor 1 (DRAF1), for some IFN-inducible genes.

Go back
190.0, 614.0
27.0, 27.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c47 : 1
stoichiometry:c45 : 1

m980*m155666*0.1

nodelay

--

true

0

false

PMID: 11790540, 9822609, 9877175, 9786932 Subsequently the de novo produced IRF-7 undergoes virus-induced phosphorylation, similar to IRF-3, and activates the IFN-alpha/beta promoters. PMID: 11790540, 3805784, 6802744 In this context, it is interesting to note that IFN-alpha/beta are also induced by nonviral, pathogen-associated molecules, such as lipopolysaccharide (LPS) and unmethylated DNA.

Go back
349.0, 1093.0
21.0, 21.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c50 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 11790540, 9822609, 9877175, 9786932 Subsequently the de novo produced IRF-7 undergoes virus-induced phosphorylation, similar to IRF-3, and activates the IFN-alpha/beta promoters. PMID: 11790540, 11318879 In the absence of the other, IRF-3 acts on the IFN-beta gene, whereas IRF-7 acts on both IFN-alpha and IFN-beta genes by forming homodimers, and both IRF-3 and IRF-7 are required, functioning as a heterodimer, for amplifying the induction of IFN-beta and certain IFN-alpha family genes. PMID: 11790540, 3805784, 6802744 In this context, it is interesting to note that IFN-alpha/beta are also induced by nonviral, pathogen-associated molecules, such as lipopolysaccharide (LPS) and unmethylated DNA.

Go back
461.0, 1157.0
21.0, 21.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c51 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 11790540, 9822609, 9877175, 9786932 Subsequently the de novo produced IRF-7 undergoes virus-induced phosphorylation, similar to IRF-3, and activates the IFN-alpha/beta promoters. PMID: 11790540, 11318879 In the absence of the other, IRF-3 acts on the IFN-beta gene, whereas IRF-7 acts on both IFN-alpha and IFN-beta genes by forming homodimers, and both IRF-3 and IRF-7 are required, functioning as a heterodimer, for amplifying the induction of IFN-beta and certain IFN-alpha family genes. PMID: 11790540, 3805784, 6802744 In this context, it is interesting to note that IFN-alpha/beta are also induced by nonviral, pathogen-associated molecules, such as lipopolysaccharide (LPS) and unmethylated DNA.

Go back
1006.0, 290.0
27.0, 27.0

p2

p2

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 11790540, 11355893 In turn, virally induced IFN-alpha/beta activates Jak protein tyrosine kinases (Jak1 and Tyk2), leading to formation of both the ISGF3 transcriptional complex and AAF: the former activates several IFN-inducible genes including IRF-7 [39], whereas the latter mediates activation of the IRF-1 gene by its binding to GAS (IFN-gamma-activated site).

Go back
239.0, 991.0
25.0, 25.0

p20

p20

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 11790540, 11318879 In the absence of the other, IRF-3 acts on the IFN-beta gene, whereas IRF-7 acts on both IFN-alpha and IFN-beta genes by forming homodimers, and both IRF-3 and IRF-7 are required, functioning as a heterodimer, for amplifying the induction of IFN-beta and certain IFN-alpha family genes.

Go back
372.0, 1112.0
23.0, 23.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c55 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 11790540, 11318879 In the absence of the other, IRF-3 acts on the IFN-beta gene, whereas IRF-7 acts on both IFN-alpha and IFN-beta genes by forming homodimers, and both IRF-3 and IRF-7 are required, functioning as a heterodimer, for amplifying the induction of IFN-beta and certain IFN-alpha family genes.

Go back
484.0, 1176.0
23.0, 23.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c54 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 11790540, 11318879 In the absence of the other, IRF-3 acts on the IFN-beta gene, whereas IRF-7 acts on both IFN-alpha and IFN-beta genes by forming homodimers, and both IRF-3 and IRF-7 are required, functioning as a heterodimer, for amplifying the induction of IFN-beta and certain IFN-alpha family genes.

Go back
392.0, 1136.0
23.0, 23.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c59 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 11790540, 3805784, 6802744 In this context, it is interesting to note that IFN-alpha/beta are also induced by nonviral, pathogen-associated molecules, such as lipopolysaccharide (LPS) and unmethylated DNA.

Go back
517.0, 1181.0
21.0, 21.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c58 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 11790540, 3805784, 6802744 In this context, it is interesting to note that IFN-alpha/beta are also induced by nonviral, pathogen-associated molecules, such as lipopolysaccharide (LPS) and unmethylated DNA.

Go back
440.0, 1008.0
23.0, 23.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c64 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 11790540 More recently, genetic evidence has indicated that some IFN-inducible genes, such as ISG15 and IP-10, are indeed activated in virally infected cells in the absence of ISGF3 by a mechanism dependent on IRF-3 (in the context of the DRAF1 complex) but not on IRF-7.

Go back
451.0, 1055.0
25.0, 25.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c65 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 11790540 More recently, genetic evidence has indicated that some IFN-inducible genes, such as ISG15 and IP-10, are indeed activated in virally infected cells in the absence of ISGF3 by a mechanism dependent on IRF-3 (in the context of the DRAF1 complex) but not on IRF-7.

Go back
528.0, 956.0
23.0, 23.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c68 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 11790540 Moreover, these genes are also activated by ISGF3 in the absence of IRF-3.

Go back
536.0, 996.0
23.0, 23.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c69 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 11790540 Moreover, these genes are also activated by ISGF3 in the absence of IRF-3.

Go back
581.0, 1013.0
21.0, 21.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 11790540, 11355893 By contrast, the induction of other genes, such as 2¡ì-5¡ì oligoadenylate synthetase (OAS) and double-stranded-RNA-dependent protein kinase (PKR) is totally dependent on ISGF3, which cannot directly activate the IFN-alpha/beta genes.

Go back
707.0, 347.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c10 : 1
stoichiometry:c9 : 1

m1357*m1358*m12*m18*0.1

nodelay

--

true

0

false

PMID: 11790540 The IFN-alpha/beta stimulation of the homologous receptor complex, termed IFNAR, leads to the formation of two transcriptional activator complexes: IFN-alpha-activated factor (AAF), which is a homodimer of signal transducer and activator of transcription (Stat)1; and IFN-stimulated gene factor 3 (ISGF3), which comprises Stat1, Stat2 and a member of the IRF family, IRF-9 (also known as p48).

Go back
617.0, 1029.0
21.0, 21.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c72 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 11790540, 11355893 By contrast, the induction of other genes, such as 2¡ì-5¡ì oligoadenylate synthetase (OAS) and double-stranded-RNA-dependent protein kinase (PKR) is totally dependent on ISGF3, which cannot directly activate the IFN-alpha/beta genes.

Go back
552.0, 1184.0
23.0, 23.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m1636*0.1

nodelay

--

true

0

false

PMID: 11790540, 10875919, 9501984 In fibroblasts, IFN-alpha/beta expression is observed even after serum starvation, and IFN-alpha expression in these cells is dependent on IFN-beta for an as-yet-unknown reason.

Go back
1004.0, 1104.0
23.0, 23.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m3258*m3373*0.1

nodelay

--

true

0

false

PMID: 11790540 More recently, we found that the IFN-beta gene is induced in bone marrow macrophages upon stimulation by RANK ligand (receptor activator of NF-kappaB ligand) as a negative regulator of osteoclast differentiation, and that this induction is not dependent on IRFs but on RANKL-induced c-Fos, one of the essential transcriptional factors for osteoclast differentiation.

Go back
699.0, 1103.0
25.0, 25.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 11790540 More recently, we found that the IFN-beta gene is induced in bone marrow macrophages upon stimulation by RANK ligand (receptor activator of NF-kappaB ligand) as a negative regulator of osteoclast differentiation, and that this induction is not dependent on IRFs but on RANKL-induced c-Fos, one of the essential transcriptional factors for osteoclast differentiation.

Go back
580.0, 1116.0
23.0, 23.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m221*0.1

nodelay

--

true

0

false

PMID: 11790540 More recently, we found that the IFN-beta gene is induced in bone marrow macrophages upon stimulation by RANK ligand (receptor activator of NF-kappaB ligand) as a negative regulator of osteoclast differentiation, and that this induction is not dependent on IRFs but on RANKL-induced c-Fos, one of the essential transcriptional factors for osteoclast differentiation.

Go back
758.0, 1162.0
27.0, 27.0

p35

p35

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c81 : 1

m93203*0.1

nodelay

--

true

0

false

PMID: 11790540 More recently, we found that the IFN-beta gene is induced in bone marrow macrophages upon stimulation by RANK ligand (receptor activator of NF-kappaB ligand) as a negative regulator of osteoclast differentiation, and that this induction is not dependent on IRFs but on RANKL-induced c-Fos, one of the essential transcriptional factors for osteoclast differentiation.

Go back
332.0, 1068.0
23.0, 23.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c85 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 11790540, 9541017, 9660935, 9446577 We also speculate that IFN-beta represents the prototype IFN gene, which is subject to induction by a various factors such as IRF-3, c-Fos and NF-kappaB.

Go back
1006.0, 1206.0
27.0, 27.0

p37

p37

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m221*0.1

nodelay

--

true

0

false

PMID: 11790540 More recently, we found that the IFN-beta gene is induced in bone marrow macrophages upon stimulation by RANK ligand (receptor activator of NF-kappaB ligand) as a negative regulator of osteoclast differentiation, and that this induction is not dependent on IRFs but on RANKL-induced c-Fos, one of the essential transcriptional factors for osteoclast differentiation.

Go back
609.0, 705.0
29.0, 29.0

p38

p38

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c89 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 11790540 The latter mediates activation of the IRF-1 gene by its binding to GAS (IFN-gamma-activated site).

Go back
686.0, 706.0
27.0, 27.0

p39

p39

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c91 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 11790540, 8197455 ISGF3 binds to cis elements, termed IFN-stimulated response elements (ISREs; consensus sequence A/GNGAAANNGAAACT), which usually reside within the promoter region of IFN-inducible genes [5].

Go back
708.0, 300.0
23.0, 23.0

p4

p4

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c13 : 1
stoichiometry:c12 : 1

m1357*m18*0.1

nodelay

--

true

0

false

PMID: 11790540 The IFN-alpha/beta stimulation of the homologous receptor complex, termed IFNAR, leads to the formation of two transcriptional activator complexes: IFN-alpha-activated factor (AAF), which is a homodimer of signal transducer and activator of transcription (Stat)1; and IFN-stimulated gene factor 3 (ISGF3), which comprises Stat1, Stat2 and a member of the IRF family, IRF-9 (also known as p48).

Go back
293.0, 613.0
30.0, 30.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m19324*m19325*0.1

nodelay

--

true

0

false

--

Go back
528.0, 860.0
23.0, 23.0

p5

p5

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c90 : 1
stoichiometry:c16 : 1

m20*m6*0.1

nodelay

--

true

0

false

PMID: 11790540 The latter mediates activation of the IRF-1 gene by its binding to GAS (IFN-gamma-activated site).

Go back
540.0, 908.0
23.0, 23.0

p6

p6

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 11790540 The latter mediates activation of the IRF-1 gene by its binding to GAS (IFN-gamma-activated site).

Go back
629.0, 873.0
22.0, 22.0

p7

p7

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c92 : 1
stoichiometry:c20 : 1

m21*m33*0.1

nodelay

--

true

0

false

PMID: 11790540, 8197455 ISGF3 binds to cis elements, termed IFN-stimulated response elements (ISREs; consensus sequence A/GNGAAANNGAAACT), which usually reside within the promoter region of IFN-inducible genes [5].

Go back
660.0, 964.0
23.0, 23.0

p8

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c22 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 11790540, 11355893 The former activates several IFN-inducible genes including IRF-7.

Go back
707.0, 943.0
25.0, 25.0

p9

p9

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m970*m21*0.1

nodelay

--

true

0

false

PMID: 11790540, 2342456, 7687740 ISREs are also known to bind and be activated by IRF-1.

Go back
955.0, 193.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
739.756413487951, 308.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
678.0, 312.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
731.0, 318.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
738.9948504727106, 305.0

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
636.9902267446631, 387.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.0, 833.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
495.0, 872.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
476.0, 878.0

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
519.0, 920.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
659.0, 884.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1048.0, 180.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
647.0, 895.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
710.696811669982, 445.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
672.0, 987.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
672.0, 938.0

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
738.4698886744255, 969.7053735814004

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.0, 888.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
722.0, 968.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.0, 1018.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
703.0, 1068.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
73.0, 523.9306585370963

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
963.0, 248.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
228.8362976331207, 476.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
223.0, 516.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
231.9958409147176, 460.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.0, 471.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
75.0, 468.8479626207359

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
276.0, 532.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
288.0, 892.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
360.4436087949382, 906.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
363.0, 932.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.0, 943.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
955.0, 258.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.0, 1054.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
341.5909734841225, 1009.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
222.99001871102277, 573.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
214.0, 587.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
219.97115768801635, 585.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
217.0, 628.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
75.0, 526.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
73.0, 581.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
269.0, 1115.0523923890469

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
269.0, 1168.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
963.0, 304.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.0, 1101.420470664982

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
482.0, 1154.3151160102107

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
252.0, 642.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.0, 1016.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
507.0, 1167.3149107106394

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
395.0, 1108.2065506721576

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
316.0, 1140.4990785985597

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
320.0, 1189.4869005636044

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
531.0, 1170.7081432770394

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
413.0, 1119.3000400080607

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.0, 324.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
413.76284571916636, 1166.059815301674

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
520.0, 1209.9892273979074

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
359.0, 992.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
359.0, 998.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
463.0, 1020.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
476.0, 1068.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
558.7181105699019, 938.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
565.8246162947313, 938.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
518.5536798306425, 979.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
548.0, 1019.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
677.0, 357.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
606.2394443073428, 938.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
592.0, 1034.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
628.0, 1050.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
635.013200663471, 938.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
582.192874166032, 1204.501794001884

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
551.4394686431388, 1170.2228841505914

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
945.0, 1069.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1016.0, 1075.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
955.0, 1116.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
732.0, 1116.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
679.0, 373.326060730508

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.3404450024794, 1121.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.0856580228888, 1189.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
669.0, 1144.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
609.7422840299793, 1139.305996523348

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
460.8608673540657, 1103.4855182401384

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
355.0, 1082.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
230.0, 1080.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
750.0, 1220.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
945.0, 1131.0

c88

c88

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
573.1424214352462, 734.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
732.0, 366.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
548.1513543886333, 839.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
659.5037553862376, 733.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
643.1313708498985, 845.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
281.0, 532.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.0, 628.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
304.0587140149624, 643.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back