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H2O2</text>
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ONOO-</text>
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NO</text>
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Indirect
PMID: 11841920
Addition of LPS to cultured HM results in induced expression of TNF-alpha with its mRNA and protein expression peaking at 2–4 and 6–8 h, respectively.
PMID: 11841920, 8386517
IL-10 inhibits TNF-alpha expression at both transcriptional and posttranscriptional levels.
Indirect
PMID: 11841920
Addition of LPS to cultured HM results in induced expression of TNF-alpha with its mRNA and protein expression peaking at 2–4 and 6–8 h, respectively. Induction of IL-10 lags slightly behind that of TNF-alpha.
Indirect
PMID: 11841920, 9180188
Iron overloading in mice causes suppressed candidacidal activity by macrophages and reduced release of NO and IL-12 and enhanced production of IL-4 and IL-10 by splenic CD4+ T cells.
Indirect
PMID: 11841920, 9180188
Iron overloading in mice causes suppressed candidacidal activity by macrophages and reduced release of NO and IL-12 and enhanced production of IL-4 and IL-10 by splenic CD4+ T cells.
Indirect
PMID: 11841920
increased iron content may promote NF-kappaB activation and TNF-alpha expression.
Indirect
PMID: 11841920
increased iron content may promote NF-kappaB activation and TNF-alpha expression.
PMID: 11841920
When the cells were pretreated with deferiprone, both the transient rise of iron and NF-kappaB activation were abrogated.
PMID: 11841920, 9710205, 8626684
In fact, low, physiological concentrations of NO are known to increase TNFalpha- or PMA-induced IKK activity, NF-kappaB binding, and promoter transactivation even though high pharmacological concentrations suppress activation of NF-kappaB.
Indirect
PMID: 11841920, 10600822
LPS treatment results in accentuated NF-kappaB activation, the effect which is abrogated by zinc protoporphyrin, a hemeoxygenase inhibitor.
iNOS abolishes LPS-mediated transient rise in LMW iron and NF-kappaB activation.
PMID: 11841920
When the cells were pretreated with deferiprone, both the transient rise of iron and NF-kappaB activation were abrogated.
PMID: 11841920, 9710205, 8626684
In fact, low, physiological concentrations of NO are known to increase TNFalpha- or PMA-induced IKK activity, NF-kappaB binding, and promoter transactivation even though high pharmacological concentrations suppress activation of NF-kappaB.
Indirect
PMID: 11841920
This study demonstrated a transient rise in the intracellular chelatable pool of iron at 10 min following LPS stimulation.
iNOS abolishes LPS-mediated transient rise in LMW iron and NF-kappaB activation.
PMID: 11841920
When the cells were pretreated with deferiprone, both the transient rise of iron and NF-kappaB activation were abrogated.
Indirect
PMID: 118420, 2153975, 2154196
formation of nonheme iron-nitrosyl complex was previously demonstrated in LPS-stimulated macrophages.
Indirect
PMID: 11841920, 9710205
In fact, low, physiological concentrations of NO are known to increase TNF-alpha- or PMA-induced IKK activity, NF-kappaB binding.
Indirect
PMID: 11841920, 9710205
In fact, low, physiological concentrations of NO are known to increase TNF-alpha- or PMA-induced IKK activity, NF-kappaB binding.
Indirect
PMID: 11841920, 9710205
In fact, low, physiological concentrations of NO are known to increase TNF-alpha- or PMA-induced IKK activity, NF-kappaB binding.
Indirect
PMID: 11841920
LPS stimulates activities of iNOS and NADPH oxidase.
Indirect
PMID: 11841920
LPS stimulates activities of iNOS and NADPH oxidase.
PMID: 11841920, 7557022
NO may target and release iron sulfur clusters from enzymes containing them. One such enzyme is iron regulatory protein-1 (IRP-1).
Indirect
PMID: 11841920, 7557022
NO may target and release iron sulfur clusters from enzymes containing them. One such enzyme is iron regulatory protein-1 (IRP-1).
Indirect
PMID: 11841920
A transiently raised LMW-iron may directly provide redox modifications of signaling proteins for IKK activation.
Indirect
PMID: 11841920, 9512778, 10391125, 10678585
iron may produce OH from H2O2 generated from O2-.
Indirect
PMID: 11841920
OH is also produced from ONOO- generated from NO and O2.
Indirect
PMID: 11841920
OH is also produced from ONOO- generated from NO and O2.
Indirect
PMID: 11841920
OH is also produced from ONOO- generated from NO and O2.
Indirect
PMID: 11841920
iron may be released from ferritin via reduction of iron by O2-.
Indirect
PMID: 11841920
iron may be released from ferritin via reduction of iron by O2- or oxidative destruction of ferritin proteins by OH.
Indirect
PMID: 11841920, 9512778, 10391125, 10678585
iron may produce OH from H2O2 generated from O2-.
Indirect
PMID: 11841920
LPS stimulates activities of iNOS and NADPH oxidase resulting in generation of NO and O2-.
PMID: 11841920
Addition of LPS to cultured HM results in induced expression of TNF-alpha with its mRNA and protein expression peaking at 2–4 and 6–8 h, respectively.
Indirect
PMID: 11841920
LPS stimulates activities of iNOS and NADPH oxidase resulting in generation of NO and O2-.