1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/12106784.csml convertedTime:2009.07.01.10:40

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Structural and functional analyses of bacterial lipopolysaccharides.
Authors Caroff M, Karibian D, Cavaillon JM, Haeffner-Cavaillon N.
Affiliation Equipe Endotoxines, UMR 8619 du Centre National de la Recherche Scientifique,Biochimie, Universite de Paris-Sud, Orsay, France.martine.caroff@bbmpc.u-psud.fr
Abstract Bacterial lipopolysaccharides (LPSs) are powerful immunomodulators in infectedhosts, and may cause endotoxic shock. Most of them share a common architecturebut vary considerably in structural motifs from one genus, species, and strainto another. Cells of the innate immune response recognize evolutionarilyconserved LPS molecular patterns of endotoxins and structural details therebygreatly influencing their response.
PMID 12106784
Model Abstract

Entity

e1: e10: e11:LPS:CD14 e12:CD55 e13:HSP70/HSP90/CXCR4/GDF e14:P2X7 e15:LPS:P2X7 e16:LPS: HSP70/HSP90/CXCR4/GDF e17:LPS: CD55 e18:CR3 e19:LPS: CR3 e2: e20:TLR2 e21:LPS: TLR2 e22:TLR4 e23:LPS: TLR4 e24:MyD88 e25:LPS: TLR4: MyD88 e26:IRAK1 e27:IRAK1{activated} e28:TRAF6 e29:TRAF6{activated} e3: e30:IKK-alpha/beta e31:IKK-alpha/beta{activated} e32:p65/p50 e33:p65/p50{activated} e34:TIRAP e35:LPS: TLR4: TIRAP e36:PKR e37:PKR{activated} e38:MKK3 e39:MKK3{activated} e4: e40:p38 MAPK e41:p38MAPK{activated} e42:IL-8 e43:IL-6 e44:ATF-2 e45:ATF-2{activated} e46:IL-12 e47:B7-2 e48:MKK6 e49:MKK6{activated} e5:LPS e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:CD14 e60: e61: e62: e63:c-Jun e64:c-Jun{activated} e65:p65/p50_nucleus e66:pI-3 kinase e67:pI-3 kinase{activated} e68:TNF-alpha e69:B7-1 e7: e70:IL-1beta e71:IL-1ra e72:IL-1 e73:IL-1alpha e74:HLA-DR e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p4 p5 p6 p7 p8 p9
Model Detail
118.75, 161.3006538632727
856.2594311764528, 1333.9849482140532

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
127.0, 181.68999610237574
829.9775981223105, 1252.715963782007

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
768.375, 133.5
40.22149747862312, 77.84805963604474

LPS:CD14

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p6 p7 p30

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
145.5, 282.125
45.0, 27.75

CD55

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
125.5, 443.125
45.0, 33.75

HSP70/HSP90/CXCR4/GDF

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
256.375, 153.5
39.782513181019326, 61.20386643233744

P2X7

--

e14

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p2

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
192.375, 133.5
39.786505152378865, 77.00613900460425

LPS:P2X7

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
108.625, 499.5
46.14010164972505, 56.49808365272454

LPS: HSP70/HSP90/CXCR4/GDF

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
123.625, 333.5
49.038785202466265, 60.04749208465256

LPS: CD55

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
929.375, 191.5
36.44683655536028, 56.072056239015815

CR3

--

e18

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p5

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
888.375, 138.5
39.11362639771979, 75.70379302784478

LPS: CR3

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
118.75, 161.3006538632727
856.2594311764528, 1333.9849482140532

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
648.375, 153.5
40.216608084358526, 61.87170474516695

TLR2

--

e20

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p6

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
708.375, 137.5
39.874862968647236, 77.17715413286558

LPS: TLR2

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
315.375, 148.5
40.51362038664324, 62.32864674868189

TLR4

--

e22

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p7

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
497.375, 140.5
36.347347073010305, 70.34970401227802

LPS: TLR4

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p8 p13 p24 p31 p17 p19 p28 p34 p35 p36

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
554.25, 169.5
19.5, 45.0

MyD88

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
589.375, 136.5
36.401721113790835, 70.45494409120806

LPS: TLR4: MyD88

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p9

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
661.5, 263.125
45.0, 33.75

IRAK1

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
669.5, 307.125
45.0, 33.75

IRAK1{activated}

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

p9

p10

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
678.125, 353.5
27.75, 45.0

TRAF6

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
678.125, 409.5
27.75, 45.0

TRAF6{activated}

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

p10

p11

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
135.87518862352903, 179.67510218578036
822.0090539293948, 1297.2360515690389

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
673.625, 469.5
36.75, 45.0

IKK-alpha/beta

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
673.625, 533.5
36.75, 45.0

IKK-alpha/beta{activated}

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p12

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
671.75, 609.5
40.5, 45.0

p65/p50

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p12 p25

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
671.75, 681.5
40.5, 45.0

p65/p50{activated}

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12 p25

p23

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
446.25, 165.5
19.5, 45.0

TIRAP

--

e34

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p13

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
379.375, 140.5
40.676880070160045, 78.72944529708397

LPS: TLR4: TIRAP

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

p14

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
309.5, 290.125
45.0, 27.75

PKR

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p14

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
309.5, 422.125
45.0, 27.75

PKR{activated}

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

p14

p15 p20

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
406.125, 413.5
27.75, 45.0

MKK3

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
406.125, 481.5
27.75, 45.0

MKK3{activated}

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

p15

p16

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
167.55678757705792, 211.8303867501685
758.6458560223374, 1232.9254824402615

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
313.5, 547.125
45.0, 33.75

p38 MAPK

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16 p21

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
313.5, 631.125
45.0, 33.75

p38MAPK{activated}

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

p16 p21

p18 p22 p29 p32 p33

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
589.5, 1008.0
45.0, 24.0

IL-8

--

e42

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p19

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
605.5, 960.0
45.0, 24.0

IL-6

--

e43

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p17

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
414.125, 649.5
27.75, 45.0

ATF-2

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p18

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
414.125, 853.5
27.75, 45.0

ATF-2{activated}

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

p18

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
585.5, 1060.0
45.0, 24.0

IL-12

--

e46

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p28

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
421.5, 1076.0
45.0, 24.0

B7-2

--

e47

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p34

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
230.125, 417.5
27.75, 45.0

MKK6

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
230.125, 485.5
27.75, 45.0

MKK6{activated}

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

p20

p21

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
513.5, 16.25
53.95710681244743, 30.575693860386878

LPS

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p1 p2 p3 p4 p5

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
300.0, 930.6081663518404
465.6500709748862, 453.09919849962154

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
350.29367619468036, 941.3459586536558
272.27955732982184, 439.14337103043397

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
306.06992643728904, 936.6556915884883
453.51021810030846, 441.00414802632554

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
306.93705878547314, 937.5860800864341
451.7759534039399, 439.14337103043397

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
300.0, 930.6081663518404
465.6500709748862, 453.09919849962154

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
300.0, 930.6081663518404
465.6500709748862, 453.09919849962154

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
306.93705878547314, 937.5860800864341
451.7759534039399, 439.14337103043397

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
639.9158804881849, 1116.6858659410073
29.091257918298922, 28.256364981703864

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
563.6082338479803, 1246.9402556534242
82.37757307749382, 80.01341082334184

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
300.0, 930.6081663518404
465.6500709748862, 453.09919849962154

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
831.375, 148.5
41.19903339191565, 63.38312829525482

CD14

--

e6

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
409.7511016961721, 1131.961706175573
14.746453546866459, 7.618090369513086

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
409.25867587120234, 1109.2427579574405
50.4736470593979, 97.48013828477765

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
430.43298634490145, 1172.6444739150197
7.878813199515761, 8.453562127677191

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
218.125, 657.5
27.75, 45.0

c-Jun

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p22

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
218.125, 849.5
27.75, 45.0

c-Jun{activated}

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

p22

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
671.75, 1117.5
40.5, 45.0

p65/p50_nucleus

--

e65

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p23

p26 p27

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
809.5, 242.125
45.0, 27.75

pI-3 kinase

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p24

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
809.5, 398.125
45.0, 27.75

pI-3 kinase{activated}

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

p24

p25

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
529.5, 1128.0
45.0, 24.0

TNF-alpha

--

e68

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p26 p33

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
409.5, 1032.0
45.0, 24.0

B7-1

--

e69

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p35

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
130.0, 166.66871475066725
839.7237354966342, 1276.6660441811762

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
645.5, 1004.0
45.0, 24.0

IL-1beta

--

e70

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p27

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
369.5, 1200.0
44.221453287197235, 23.58477508650519

IL-1ra

--

e71

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p29

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
493.5, 1236.0
45.0, 24.0

IL-1

--

e72

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p30 p31

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
349.5, 1256.0
45.0, 24.0

IL-1alpha

--

e73

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p32

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
393.5, 988.0
45.0, 24.0

HLA-DR

--

e74

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p36

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
133.0, 189.20063677822992
805.5569854171277, 1254.9945195916794

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
141.0, 211.73255880579262
801.8791759029863, 1238.535580940407

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
857.0, 77.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 e5

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m6*m5*0.1

nodelay

--

true

0

false

PMID: 12106784, 10706718 Epitope-mapping studies revealed that CD14 selectively recognizes E. coli, P. gingivalis and H. pylori LPSs and that hydrophilic domains of the amino-terminal region of CD14 are involved in LPS binding.

Go back
593.0, 417.0
30.0, 30.0

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 e27

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m28*m27*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
593.0, 541.0
30.0, 30.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c32 : 1

m30*m29*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
593.0, 689.0
30.0, 30.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e31

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m32*m31*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
441.0, 241.0
30.0, 30.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e34 e23

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m34*m23*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
317.0, 361.0
30.0, 30.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 e35

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c46 : 1
stoichiometry:c41 : 1

m36*m35*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
341.0, 489.0
30.0, 30.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e38 e37

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c47 : 1
stoichiometry:c43 : 1

m38*m37*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
373.0, 561.0
30.0, 30.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e40 e39

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c48 : 1
stoichiometry:c45 : 1

m40*m39*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
553.0, 957.0
30.0, 30.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c52 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 12106784, 9058830, 10940876 human PBMC in the presence of IL-4 and granulocyte-macrophage-CSF, produce high levels of TNF-¦Á, IL-6, IL-8, and IL-12 upon LPS stimulation.

Go back
413.0, 773.0
30.0, 30.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44 e41

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c55 : 1
stoichiometry:c50 : 1

m44*m41*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
537.0, 1005.0
30.0, 30.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c51 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 12106784, 9058830, 10940876 human PBMC in the presence of IL-4 and granulocyte-macrophage-CSF, produce high levels of TNF-¦Á, IL-6, IL-8, and IL-12 upon LPS stimulation.

Go back
237.0, 101.0
30.0, 30.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e14 e5

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m14*m5*0.1

nodelay

--

true

0

false

PMID: 12106784, 11489964 several other molecules are still good candidates as LPS receptors, i.e., complement CR3 receptor, CD55 , HSP 70 and 90 associated with CXCR4 and GDF, P2X7, etc.

Go back
289.0, 493.0
30.0, 30.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e48 e37

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c61 : 1
stoichiometry:c60 : 1

m48*m37*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
265.0, 561.0
30.0, 30.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e40 e49

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c64 : 1
stoichiometry:c63 : 1

m40*m49*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
217.0, 757.0
30.0, 30.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e63 e41

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c67 : 1
stoichiometry:c66 : 1

m63*m41*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
677.0, 849.0
30.0, 30.0

p23

p23

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e33

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
817.0, 301.0
30.0, 30.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e66 e23

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c72 : 1
stoichiometry:c71 : 1

m66*m23*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
817.0, 689.0
30.0, 30.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e67 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m67*m32*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
609.0, 1125.0
30.0, 30.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e65

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 12106784 Fig.4

Go back
657.0, 1057.0
30.0, 30.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e65

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c53 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 12106784 Fig.4

Go back
517.0, 1057.0
30.0, 30.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c78 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 12106784, 9058830, 10940876 human PBMC in the presence of IL-4 and granulocyte-macrophage-CSF, produce high levels of TNF-¦Á, IL-6, IL-8, and IL-12 upon LPS stimulation.

Go back
345.0, 1137.0
30.0, 30.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e41

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c84 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 12106784, 11402003 Blocking of the p38 pathway before LPS stimulation decreased IL-1¦Á, IL-1ra, and TNF-¦Á production by human monocytes.

Go back
141.0, 101.0
30.0, 30.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 e5

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m12*m5*0.1

nodelay

--

true

0

false

PMID: 12106784, 10219599 several other molecules are still good candidates as LPS receptors, i.e., complement CR3 receptor, CD55, HSP 70 and 90 associated with CXCR4 and GDF, P2X7, etc.

Go back
705.0, 1233.0
30.0, 30.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e11

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c80 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 12106784, 9767415 LPS-induced IL-1 production is mediated by CD14-dependent mechanisms in the presence of plasma, whereas in its absence, both CD14-dependent and CD14-independent pathways are involved.

Go back
497.0, 1173.0
30.0, 30.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c81 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 12106784, 9767415 LPS-induced IL-1 production is mediated by CD14-dependent mechanisms in the presence of plasma, whereas in its absence, both CD14-dependent and CD14-independent pathways are involved.

Go back
321.0, 1185.0
30.0, 30.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e41

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c85 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 12106784, 11402003 Blocking of the p38 pathway before LPS stimulation decreased IL-1¦Á, IL-1ra, and TNF-¦Á production by human monocytes.

Go back
397.0, 1125.0
30.0, 30.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e41

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c86 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 12106784, 11402003 Blocking of the p38 pathway before LPS stimulation decreased IL-1¦Á, IL-1ra, and TNF-¦Á production by human monocytes.

Go back
477.0, 1057.0
30.0, 30.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c92 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 12106784, 10940876 human PBMC in the presence of IL-4 and granulocyte-macrophage-CSF, produce high levels of TNF-¦Á, IL-6, IL-8, and IL-12 upon LPS stimulation and upregulate their expression of HLA-DR, B7-1, B7-2, and CD40.

Go back
457.0, 1001.0
30.0, 30.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c91 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 12106784, 10940876 human PBMC in the presence of IL-4 and granulocyte-macrophage-CSF, produce high levels of TNF-¦Á, IL-6, IL-8, and IL-12 upon LPS stimulation and upregulate their expression of HLA-DR, B7-1, B7-2, and CD40.

Go back
445.0, 949.0
30.0, 30.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c90 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 12106784, 10940876 human PBMC in the presence of IL-4 and granulocyte-macrophage-CSF, produce high levels of TNF-¦Á, IL-6, IL-8, and IL-12 upon LPS stimulation and upregulate their expression of HLA-DR, B7-1, B7-2, and CD40.

Go back
93.0, 57.0
30.0, 30.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 e5

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m13*m5*0.1

nodelay

--

true

0

false

PMID: 12106784, 11276205 several other molecules are still good candidates as LPS receptors, i.e., complement CR3 receptor, CD55 , HSP 70 and 90 associated with CXCR4 and GDF, P2X7, etc.

Go back
961.0, 53.0
30.0, 30.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 e5

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m18*m5*0.1

nodelay

--

true

0

false

PMID: 12106784 several other molecules are still good candidates as LPS receptors, i.e., complement CR3 receptor, CD55, HSP 70 and 90 associated with CXCR4 and GDF, P2X7, etc.

Go back
701.0, 73.0
30.0, 30.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m11*m20*0.1

nodelay

--

true

0

false

PMID: 12106784 Genetic approaches have involved TLR2 and TLR4 in LPS recognition.

Go back
521.0, 61.0
30.0, 30.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 e22

e23 e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c58 : 1

m11*m22*0.1

nodelay

--

true

0

false

PMID: 12106784 Genetic approaches have involved TLR2 and TLR4 in LPS recognition.

Go back
549.0, 245.0
30.0, 30.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m23*m24*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
593.0, 309.0
30.0, 30.0

p9

p9

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m25*m26*0.1

nodelay

--

true

0

false

PMID: 12106784 TLRs are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and an extracellular leucine-rich domain activating the MyD88/IRAK signaling cascade, which leads to NF-kB and c-Jun/ATF2/TCF activation.

Go back
859.0, 114.78244971748293

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
157.5286433380591, 138.98251440469267

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
178.81534875540018, 38.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
149.27569820671823, 131.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
953.0, 90.86863896715977

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
567.0, 34.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
931.2596089499316, 83.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
734.1734820130813, 109.1020557077369

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
683.0, 110.12724917521584

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
718.0, 103.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
558.4720767881265, 84.85798328762444

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
567.0, 37.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.0, 87.69758898383094

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
524.5689290811055, 91.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.0, 206.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.0, 215.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
571.0, 214.15541752799933

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
608.0, 207.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
629.9678277419434, 293.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.0, 324.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
629.6377768816001, 385.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.0, 432.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.7759056409234, 107.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.9057664270523, 341.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
629.3548626638176, 506.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.0, 556.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
622.4719418645126, 452.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
629.0740528189224, 649.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.0, 704.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.9281045069552, 579.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
456.0, 211.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
471.8, 201.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.73912360382013, 213.4452081011954

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
260.62816499953016, 138.55597437364926

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
332.0, 318.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
332.0, 391.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
375.50195718328627, 451.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
371.0, 504.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
359.0, 568.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.69574057168745, 591.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
339.60956667764395, 219.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
337.0, 450.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
398.22912165261033, 527.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
428.0, 695.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
274.6803481658828, 40.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
428.0, 803.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
567.0, 1020.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
583.0, 972.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
669.550416732923, 1035.9810426273839

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
517.0, 211.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
347.0, 665.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
517.0, 211.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
518.0, 211.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
551.0, 81.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
258.0, 456.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
236.87768608679752, 131.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
266.0, 508.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
312.94127111496874, 450.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
302.828398279894, 568.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.0, 591.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.0, 531.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
232.0, 703.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
232.0, 787.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
250.1345814735881, 665.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
692.0, 727.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.0, 879.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
110.80488386770384, 94.95940713618232

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
832.0, 270.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
832.0, 331.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.0, 184.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
832.0, 426.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
712.0, 642.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.0, 704.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
647.0, 1140.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
583.0, 1140.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
547.0, 1072.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.2304815589116, 1094.682769814029

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
130.9644200689087, 34.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
547.0, 1248.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
513.0, 1203.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
721.5077802979287, 211.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
512.0332637457168, 211.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
368.0, 1167.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 1215.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
427.0, 1140.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 665.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
337.0, 665.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
339.0, 665.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
109.0, 87.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.2905467105794, 977.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
454.3148177390106, 1025.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
474.4278135270821, 1077.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.217413757249, 211.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
473.4146318479159, 211.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
461.57304989407277, 211.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back