1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/12213596.csml convertedTime:2009.07.01.10:41

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Multiple signaling pathways leading to the activation of interferon regulatoryfactor 3.
Authors Servant MJ, Grandvaux N, Hiscott J.
Affiliation Terry Fox Molecular Oncology Group, Lady Davis Institute-Jewish GeneralHospital, McGill University, 3755 Cote Ste., Catherine Montreal, Que., Canada.
Abstract Virus infection of susceptible cells activates multiple signaling pathways thatorchestrate the activation of genes, such as cytokines, involved in theantiviral and innate immune response. Among the kinases induced are themitogen-activated protein (MAP) kinases, Jun-amino terminal kinases (JNK) andp38, the IkappaB kinase (IKK) and DNA-PK. In addition, virus infection alsoactivates an uncharacterized VAK responsible for the C-terminal phosphorylationand subsequent activation of interferon regulatory factor 3 (IRF-3).Virus-mediated activation of IRF-3 through VAK is dependent on viral entry andtranscription, since replication deficient virus failed to induce IRF-3activity. The pathways leading to VAK activation are not well characterized, butIRF-3 appears to represent a novel cellular detection pathway that recognizesviral nucleocapsid (N) structure. Recently, the range of inducers responsiblefor IRF-3 activation has increased. In addition to virus infection, recognitionof bacterial infection mediated through lipopolysaccharide by Toll-like receptor4 has also been reported. Furthermore, MAP kinase kinase kinase (MAPKKK)-related pathways and DNA-PK induce N-terminal phosphorylation of IRF-3.This review summarizes recent observations in the identification of novelsignaling pathways leading to IRF-3 activation.
PMID 12213596
Model Abstract

Entity

G010199:OAS G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010522:RANTES G012390:IL15 MO000000022:p38 MO000000023:JNK MO000000047:MEKK1 MO000000104:PKC MO000000136:Src family MO000000212:TRAF6 MO000000213:IRAK MO000000254:p50:RelA-p65:IkappaB-alpha{p} MO000000276:AP-1 MO000007694:IRF-3 MO000007758:ISGF-3gamma MO000008179:PKR MO000016573:MyD88 MO000016632:p50:RelA-p65 MO000016658:IFN Type I MO000016882:LPS MO000016916:MKK7 MO000016917:MKK4 MO000016966:MKK3 MO000017608:PI3K family MO000017793:Lp MO000018132:CD14 MO000018334:DNA-PK MO000019005:MKK6 MO000019387:cytokines MO000019394:TLR4 MO000019395:TLRs MO000019398:TLR3 MO000019399:TLR5 MO000019479:protein remnants MO000022185:flagellin MO000022224:dsRNA MO000022225:dsRNA:PKR MO000022533:PACT MO000022570:eIF-2alpha MO000038724:p50:RelA-p65:IkappaB-alpha MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000042012:TLR9 MO000068430:eIF-2beta e1: e10: e100:IRF-3{pT135} e101:PKR {activated} e102:lipid A e103:IKK-alpha:IKK-beta {activated}:IKK-gamma: PKR{p} e104:c-Jun: ATF2 e105:c-Jun {p}: ATF2 e106:c-Jun: ATF2 {p} e11:TLR2: TLR6 e12:IP-10 e13:PKR{p} e14:IFN Type 1 receptor: STAT1: STAT2: JAK e15:INF Type I: IFN Type 1 receptor: STAT1: STAT2: JAK e16:STAT1: STAT2 [activated} e17:ISGF-3gamma: STAT1: STAT2 {activated} e18:ISRE e19:ISGF-3gamma: STAT1: STAT2 {activated} e2: e20:ISGF-3gamma: STAT1: STAT2 {activated}: ISRE e21:PKR e22:LPS: TLR4 e23:RSV fusion protein e24:RSV fusion protein: CD14: TLR4 e25:Lp: TLR2: TLR6 e26:peptidoglycanTLR2: TLR6 e27:Zymosan: TLR2: TLR6 e28:flagellin: TLR5 e29:CpG DNA e3: e30:CpG DNA: TLR9 e31:TLR ligand e32:TLR ligand: TLR e33:TLR ligand: TLR: MyD88 e34:peptidoglycan e35:Zymosan e36:TLR ligand: TLR: MyD88: IRAK e37:TLR ligand: TLR: MyD88: IRAK: TRAF6 e38:TLR ligand: TLR: MyD88: IRAK: TRAF6 {activated} e39:IRF{p} { N terimal} e4: e40:p38{p} e41:IKK-alpha:IKK-beta:IKK-gamma {activated} e42:IP-10 e44:p50:RelA-p65 e45:p50:RelA-p65:IkappaB-alpha{p} {ub} e46:AP-1 {activated} e47:poly I: C e48:poly I: C: TLR3 e5:IFN-alpha1 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IKK-alpha:IKK-beta:IKK-gamma e60: e61: e62: e63:ISG e64:IRF-3: IRF-3 {p} e65:p300: CBP: IRF-3: IRF-3 {p} e66:p300: CBP e67:p300: CBP: IRF-3: IRF-3 {p} {nucleus} e68:p300: CBP: IRF-3: IRF-3 {p} {nucleus}: ISRE e69:ISG56 e7: e70:ISG56 e71:ISG56: ISG-3gamma e72:VAK e73:VAK {activated} e74:MKK4 {activated} e75:MKK7 {activated} e76:MKK3 {activated} e77:MKK6 {activated} e78:dsRNA: PACT e79:N protein of MeV e8: e80:N protein of MeV: IRF-3 e81:eIF-2alpha {p} e82:eIF-2beta {activated} e83:IKK-alpha:IKK-beta:IKK-gamma: PKR{p} e84:cytokines e85:LPS: TLR4: MyD88 e86:LPS: TLR4: MyD88: IRAK e87:LPS: TLR4: MyD88: IRAK: TRAF6 e88:LPS: TLR4: MyD88: IRAK: TRAF6 {activated} e89:PKC {activated} e9: e90:Src family {activated} e91:PI3K family e92:USG43 e93:doxorubicin e94:CG18 e95:MEKK1 {activated} e96:JNK {p} e97:sorbitol e98:anisomycin e99:PMA

Process

p1 p10 p100 p101 p102 p103 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p99
Model Detail
785.0, 1505.0
21.0, 21.0

OAS

--

G010199

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p7

--

true true true true

csml-variable:Double

m93189

10

false

infinite

0

unit false false false
TRANSFACG010199

--

Go back
515.0, 1466.0
23.5, 23.5

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p45

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
826.0, 1346.0
27.0, 27.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p30 p34

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
734.0, 1342.0
28.0, 28.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p29 p33

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
550.0, 1493.0
26.0, 26.0

RANTES

--

G010522

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p46

--

true true true true

csml-variable:Double

m93487

10

false

infinite

0

unit false false false
TRANSFACG010522

--

Go back
583.0, 1518.0
24.5, 24.5

IL15

--

G012390

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p47

--

true true true true

csml-variable:Double

m95141

10

false

infinite

0

unit false false false
TRANSFACG012390

--

Go back
991.0, 561.0
23.0, 23.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60 p22

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
898.0, 560.0
26.0, 26.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58 p23 p90

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
894.0, 452.0
26.0, 26.0

MEKK1

--

MO000000047

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p88

true true true true

csml-variable:Double

m99

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000047

--

Go back
285.0, 387.0
28.0, 28.0

PKC

--

MO000000104

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p82

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
283.0, 469.0
32.0, 32.0

Src family

--

MO000000136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p83

true true true true

csml-variable:Double

m122

10

false

infinite

0

unit false false false
TRANSPATHMO000000136

--

Go back
878.0, 352.0
26.0, 26.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p77

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
790.0, 364.0
25.0, 25.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p76

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
802.0, 732.0
34.0, 34.0

p50:RelA-p65:IkappaB-alpha{p}

--

MO000000254

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26 p100

p31

true true true true

csml-variable:Double

m208

10

false

infinite

0

unit false false false
TRANSPATHMO000000254

--

Go back
930.0, 1194.0
28.0, 28.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
503.0, 761.0
32.0, 32.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p39 p62 p85 p87 p89 p93 p95 p96 p97

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1036.0, 1212.0
32.0, 32.0

ISGF-3gamma

--

MO000007758

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p49

true true true true

csml-variable:Double

m991

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007758

--

Go back
476.0, 546.0
29.0, 29.0

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64 p61

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
724.0, 330.0
30.0, 30.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p75

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
736.0, 914.0
32.0, 32.0

p50:RelA-p65

--

MO000016632

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27

p28

true true true true

csml-variable:Double

m1617

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
1322.0, 1072.0
28.0, 28.0

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
316.0, 123.0
30.0, 30.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1105.0, 560.0
28.0, 28.0

MKK7

--

MO000016916

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55 p101

true true true true

csml-variable:Double

m1831

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016916

--

Go back
1097.0, 395.0
30.0, 30.0

MKK4

--

MO000016917

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54 p79

true true true true

csml-variable:Double

m1832

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016917

--

Go back
1103.0, 477.0
26.0, 26.0

MKK3

--

MO000016966

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56 p80

true true true true

csml-variable:Double

m1875

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
399.0, 421.0
32.0, 32.0

PI3K family

--

MO000017608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p84

true true true true

csml-variable:Double

m2387

10

false

infinite

0

unit false false false
TRANSPATHMO000017608

--

Go back
81.0, 1328.0
28.0, 28.0

Lp

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
225.0, 239.0
27.0, 27.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
622.0, 1068.0
26.0, 26.0

DNA-PK

--

MO000018334

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p97

true true true true

csml-variable:Double

m2978

10

false

infinite

0

unit false false false
TRANSPATHMO000018334

--

Go back
1106.0, 637.0
25.0, 25.0

MKK6

--

MO000019005

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57 p102

true true true true

csml-variable:Double

m3613

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
1096.0, 1443.0
30.0, 30.0

cytokines

--

MO000019387

cso30:c:Protein

cso30:i:CC_CellComponent

--

p74

--

true true true true

csml-variable:Double

m3957

10

false

infinite

0

unit false false false
TRANSPATHMO000019387

--

Go back
277.0, 296.0
27.0, 27.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p9

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
729.0, 291.0
28.0, 28.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
209.0, 775.0
28.0, 28.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p35

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
237.0, 1588.0
28.0, 28.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
784.0, 899.0
30.0, 30.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
138.0, 1589.0
26.0, 26.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
101.0, 592.0
28.0, 28.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

p65

p13 p59 p64

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
478.0, 512.0
34.0, 34.0

dsRNA:PKR

--

MO000022225

cso30:c:Protein

cso30:i:CC_CellComponent

--

p64

p65

true true true true

csml-variable:Double

m6524

10

false

infinite

0

unit false false false
TRANSPATHMO000022225

--

Go back
318.0, 593.0
25.0, 25.0

PACT

--

MO000022533

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59

true true true true

csml-variable:Double

m6814

10

false

infinite

0

unit false false false
InterProIPR001159
TRANSPATHMO000022533

--

Go back
605.0, 683.0
28.0, 28.0

eIF-2alpha

--

MO000022570

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p66

true true true true

csml-variable:Double

m6843

10

false

infinite

0

unit false false false
InterProIPR003029
TRANSPATHMO000022570

--

Go back
855.0, 721.0
32.0, 32.0

p50:RelA-p65:IkappaB-alpha

--

MO000038724

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p100

true true true true

csml-variable:Double

m16910

10

false

infinite

0

unit false false false
TRANSPATHMO000038724

--

Go back
227.0, 642.0
32.0, 32.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

p53 p54 p55 p56 p57 p71

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
496.0, 822.0
30.0, 30.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38 p39 p85 p89

p40 p94

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
239.0, 1698.0
30.0, 30.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
678.0, 748.0
26.0, 26.0

eIF-2beta

--

MO000068430

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p67

true true true true

csml-variable:Double

m43278

10

false

infinite

0

unit false false false
TRANSPATHMO000068430

--

Go back
194.70288971335913, 238.8869620421364
1041.264002684513, 1585.8960729762975

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
204.43439863832543, 309.97977384429583
979.0223519575014, 1444.5984887818474

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
553.5, 1160.125
34.28, 25.709999999999997

IRF-3{pT135}

--

e100

cso30:c:Protein

cso30:i:CC_Cytosol

--

p97

p103

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
476.0, 650.0
29.0, 29.0

PKR {activated}

--

e101

cso30:c:Protein

cso30:i:CC_CellComponent

--

p61

--

true true true true

csml-variable:Double

m106

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
704.5, 1856.25
45.0, 25.5

lipid A

--

e102

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p99

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
709.875, 616.5
27.578317122407782, 38.48137272894109

IKK-alpha:IKK-beta {activated}:IKK-gamma: PKR{p}

--

e103

cso30:c:Complex

cso30:i:CC_Cytosol

--

p70

p100

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
821.5, 1075.0
28.219296783869357, 34.55424095984004

c-Jun: ATF2

--

e104

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

--

p24 p92 p25

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
770.5, 1151.0
27.100649891684714, 33.18446925512415

c-Jun {p}: ATF2

--

e105

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p25

p32

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
825.5, 1135.0
28.12131311448092, 34.43426095650725

c-Jun: ATF2 {p}

--

e106

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p24 p92

p32

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
227.5, 1327.125
38.44, 28.830000000000002

TLR2: TLR6

--

e11

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p10 p11 p12

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
712.0, 1450.0
30.0, 30.0

IP-10

--

e12

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
Affymetrix1418930_at
EnsemblENSMUSG00000034855
MGDCxcl10
ProteomeHumanPSD/Cxcl10
RefSeqNM_021274
TRANSFACG001062
UnigeneMm.263514

--

Go back
476.0, 582.0
29.0, 29.0

PKR{p}

--

e13

cso30:c:Protein

cso30:i:CC_CellComponent

--

p65

p66 p69

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
TRANSPATHMO000048863

--

Go back
1169.5, 1000.0
28.695957820738133, 44.147627416520216

IFN Type 1 receptor: STAT1: STAT2: JAK

--

e14

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1171.5, 1061.0
25.43345757509318, 49.22604691953519

INF Type I: IFN Type 1 receptor: STAT1: STAT2: JAK

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p3

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1104.875, 1130.5
27.578317122407782, 38.48137272894109

STAT1: STAT2 [activated}

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p2

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1102.875, 1267.5
32.25, 45.0

ISGF-3gamma: STAT1: STAT2 {activated}

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p5

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
797.5, 1415.125
45.0, 9.75

ISRE

--

e18

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p4 p44

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
931.875, 1389.5
32.25, 45.0

ISGF-3gamma: STAT1: STAT2 {activated}

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p4

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
194.70288971335913, 238.8869620421364
1041.264002684513, 1585.8960729762975

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
881.5, 1453.625
45.0, 12.75

ISGF-3gamma: STAT1: STAT2 {activated}: ISRE

--

e20

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p4

p6 p7

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
780.0, 1468.0
24.0, 24.0

PKR

--

e21

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p6

--

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
Affymetrix116778_at
EnsemblENSMUSG00000024079
MGDEif2ak2
ProteomeHumanPSD/Eif2ak2
RefSeqNM_011163
TRANSFACG001168
UnigeneMm.378990

--

Go back
315.625, 286.5
31.05061656390602, 38.021163139476755

LPS: TLR4

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p75 p82 p83 p84 p85

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
83.5, 300.375
30.342706502636204, 19.722759226713535

RSV fusion protein

--

e23

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p9

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
222.875, 343.5
32.25, 45.0

RSV fusion protein: CD14: TLR4

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
230.875, 1375.5
32.25, 45.0

Lp: TLR2: TLR6

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
228.875, 1422.5
32.25, 45.0

peptidoglycanTLR2: TLR6

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
234.875, 1499.5
32.25, 45.0

Zymosan: TLR2: TLR6

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
236.625, 1640.5
29.319571738043663, 35.901516413931006

flagellin: TLR5

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
143.5, 1705.125
45.0, 15.75

CpG DNA

--

e29

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p15

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
215.52816976704935, 260.73126056798066
999.6134425771324, 1542.2074759246102

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
236.625, 1752.5
27.449716713881024, 33.611898016997166

CpG DNA: TLR9

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
779.5, 122.375
31.889279437609837, 20.728031634446396

TLR ligand

--

e31

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p16

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
781.625, 276.5
27.31907182136311, 33.45192467922013

TLR ligand: TLR

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p17

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
842.875, 266.5
32.25, 45.0

TLR ligand: TLR: MyD88

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p17

p18

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
85.5, 1430.375
34.068541300527244, 22.14455184534271

peptidoglycan

--

e34

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p11

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
87.5, 1512.375
30.518453427065023, 19.83699472759227

Zymosan

--

e35

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p12

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
918.875, 254.5
32.25, 45.0

TLR ligand: TLR: MyD88: IRAK

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

p19

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
977.875, 240.5
34.751559919251235, 48.49054872453661

TLR ligand: TLR: MyD88: IRAK: TRAF6

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

p20

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1033.875, 232.5
34.751559919251235, 48.49054872453661

TLR ligand: TLR: MyD88: IRAK: TRAF6 {activated}

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p21 p23 p22

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
453.5, 980.125
34.28, 25.709999999999997

IRF{p} { N terimal}

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

p87 p93 p95 p96

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
254.05493786637646, 298.9587829882082
922.5599063784789, 1465.7524310841536

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
997.5, 607.125
26.12, 19.59

p38{p}

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

p60 p22

p24

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
815.0, 587.0
34.0, 34.0

IKK-alpha:IKK-beta:IKK-gamma {activated}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21 p71 p81 p91

p26

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
685.5, 1482.0
37.110726643598625, 19.792387543252595

IP-10

--

e42

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p99

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
736.0, 1212.0
32.0, 32.0

p50:RelA-p65

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

p29 p30 p72

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
802.875, 834.5
32.25, 45.0

p50:RelA-p65:IkappaB-alpha{p} {ub}

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

p27

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
854.0, 1242.0
28.0, 28.0

AP-1 {activated}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

p33 p34 p73

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
24.5, 714.25
37.026913372582, 20.98191757779647

poly I: C

--

e47

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p35

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
225.625, 708.5
27.229253457757043, 33.341943009498415

poly I: C: TLR3

--

e48

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p35

p36 p37

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
486.0, 1424.0
25.0, 25.0

IFN-alpha1

--

e5

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p43

--

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHG016992

--

Go back
417.56196536367315, 1030.462890979717
581.4095147654737, 553.0750443426506

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
480.3585237554746, 1043.5699654859932
339.96757474182283, 536.0398787058134

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
425.14086034199397, 1037.844796089013
566.2517248088326, 538.3112341240584

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
426.2235596246112, 1038.9804737981353
564.0863262435975, 536.0398787058134

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
417.56196536367315, 1030.462890979717
581.4095147654737, 553.0750443426506

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
417.56196536367315, 1030.462890979717
581.4095147654737, 553.0750443426506

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
426.2235596246112, 1038.9804737981353
564.0863262435975, 536.0398787058134

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
841.9800841496426, 1257.598432804215
36.32327192559933, 34.49110121352608

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
746.702547279323, 1416.5933120813625
102.85643184864057, 97.66828298453389

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
417.56196536367315, 1030.462890979717
581.4095147654737, 553.0750443426506

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
794.0, 524.0
34.0, 34.0

IKK-alpha:IKK-beta:IKK-gamma

--

e6

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p69 p71 p81 p91

true true true true

csml-variable:Double

m6

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
554.5969166277287, 1276.2448705888764
18.412385041078696, 9.299013732261747

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
553.982074973449, 1248.5130111312342
63.021269563665555, 118.98902488221059

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
580.4202661074751, 1325.904246826981
9.837466468474615, 10.318831426099552

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
496.5, 1299.0
37.110726643598625, 19.792387543252595

ISG

--

e63

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p37

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
493.5, 928.125
34.28, 25.709999999999997

IRF-3: IRF-3 {p}

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

p40

p41

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
494.5, 1026.0
33.24628372178381, 46.3901633327216

p300: CBP: IRF-3: IRF-3 {p}

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41 p103

p42

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
577.625, 977.5
25.939135144142647, 31.762206298950176

p300: CBP

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p41

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
586.5, 1218.0
33.24628372178381, 46.3901633327216

p300: CBP: IRF-3: IRF-3 {p} {nucleus}

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p44 p103

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
540.5, 1346.625
45.0, 12.75

p300: CBP: IRF-3: IRF-3 {p} {nucleus}: ISRE

--

e68

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p44

p43 p45 p46 p47 p48 p86

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
632.5, 1540.0
37.214532871972324, 19.847750865051903

ISG56

--

e69

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p48

p52

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
207.97312915649502, 292.65763461432033
990.5186698777655, 1472.217079868043

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1008.5, 1143.125
28.200000000000003, 21.149999999999995

ISG56

--

e70

cso30:c:Protein

cso30:i:CC_Cytosol

--

p52

p49 p51

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1052.625, 1283.5
29.499208465255794, 36.12147975337444

ISG56: ISG-3gamma

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p49

p50

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
293.5, 730.125
34.857114107466295, 21.495220366270882

VAK

--

e72

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p53 p63

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
325.5, 770.125
35.4125578587241, 21.837744012879856

VAK {activated}

--

e73

cso30:c:Protein

cso30:i:CC_Cytosol

--

p53 p63

p39

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1097.0, 435.0
30.0, 30.0

MKK4 {activated}

--

e74

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54 p79

p58

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016917

--

Go back
1105.0, 600.0
28.0, 28.0

MKK7 {activated}

--

e75

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55 p101

p60

true true true true

csml-variable:Double

m78

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016916

--

Go back
1102.0, 516.0
26.0, 26.0

MKK3 {activated}

--

e76

cso30:c:Protein

cso30:i:CC_CellComponent

--

p56 p80

p60

true true true true

csml-variable:Double

m79

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
1106.0, 669.0
25.0, 25.0

MKK6 {activated}

--

e77

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57 p102

p58

true true true true

csml-variable:Double

m80

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
395.5, 647.0
31.828361939676718, 38.973504415930684

dsRNA: PACT

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p59

p38 p61

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
154.5, 882.375
32.170474516695954, 20.910808435852374

N protein of MeV

--

e79

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p62 p63

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
211.5118596746646, 318.64084345928376
950.2163628067578, 1447.2260582983408

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
316.625, 875.5
28.02945342442926, 34.321779703382774

N protein of MeV: IRF-3

--

e80

cso30:c:Complex

cso30:i:CC_Cytosol

--

p62

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
538.5, 745.125
33.32, 24.989999999999995

eIF-2alpha {p}

--

e81

cso30:c:Protein

cso30:i:CC_Cytosol

--

p66

p67 p68

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
678.0, 780.0
26.0, 26.0

eIF-2beta {activated}

--

e82

cso30:c:Protein

cso30:i:CC_CellComponent

--

p67

--

true true true true

csml-variable:Double

m85

10

false

infinite

0

unit false false false
TRANSPATHMO000068430

--

Go back
603.875, 625.5
32.25, 45.0

IKK-alpha:IKK-beta:IKK-gamma: PKR{p}

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p69

p70

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
939.5, 1355.0
32.076124567474054, 17.10726643598616

cytokines

--

e84

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p36 p72 p73

p74

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
362.875, 271.5
32.25, 45.0

LPS: TLR4: MyD88

--

e85

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p75

p76

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
406.875, 255.5
32.25, 45.0

LPS: TLR4: MyD88: IRAK

--

e86

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p76

p77

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
457.875, 241.5
34.88571297485777, 48.67773903468526

LPS: TLR4: MyD88: IRAK: TRAF6

--

e87

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p77

p78

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
585.875, 264.5
34.42012295834098, 48.028078546522295

LPS: TLR4: MyD88: IRAK: TRAF6 {activated}

--

e88

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p78

p79 p80 p81 p101 p102

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
285.0, 427.0
28.0, 28.0

PKC {activated}

--

e89

cso30:c:Protein

cso30:i:CC_CellComponent

--

p82

--

true true true true

csml-variable:Double

m93

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
220.94847438978343, 344.6240523042471
945.8781038841892, 1428.246051185796

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
287.0, 509.0
32.0, 32.0

Src family {activated}

--

e90

cso30:c:Protein

cso30:i:CC_CellComponent

--

p83

--

true true true true

csml-variable:Double

m94

10

false

infinite

0

unit false false false
TRANSPATHMO000000136

--

Go back
475.0, 469.0
32.0, 32.0

PI3K family

--

e91

cso30:c:Protein

cso30:i:CC_CellComponent

--

p84

--

true true true true

csml-variable:Double

m95

10

false

infinite

0

unit false false false
TRANSPATHMO000017608

--

Go back
636.5, 1407.0
37.110726643598625, 19.792387543252595

USG43

--

e92

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p86

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
32.5, 850.25
36.92598822539949, 20.924726661059715

doxorubicin

--

e93

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p87

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
781.0, 454.5
40.92514718250631, 23.19091673675357

CG18

--

e94

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p88

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
850.0, 496.0
26.0, 26.0

MEKK1 {activated}

--

e95

cso30:c:Protein

cso30:i:CC_CellComponent

--

p88

p90 p91 p96

true true true true

csml-variable:Double

m100

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000047

--

Go back
898.5, 617.125
32.36, 24.269999999999996

JNK {p}

--

e96

cso30:c:Protein

cso30:i:CC_Cytosol

--

p58 p23 p90

p89 p92 p25

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
75.5, 912.25
30.214465937762817, 17.121530698065598

sorbitol

--

e97

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p93

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
69.5, 943.25
35.260723296888145, 19.981076534903277

anisomycin

--

e98

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p94

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
69.5, 983.25
34.85702270815811, 19.752312867956267

PMA

--

e99

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p95

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1260.0, 1074.0
24.0, 24.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016658 e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m1634*m15*0.1

nodelay

--

true

0

false

PMID: 12213596 Once produced, these secreted proteins act in a paracrine fashion to induce gene expression in target cells in the adjacent microenvironment, through engagement of cell surface IFN receptors and the JAK-STAT signaling pathway.

Go back
154.0, 1329.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 MO000017793

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c46 : 1
stoichiometry:c26 : 1

m11*m2549*0.1

nodelay

--

true

0

false

PMID: 12213596, 11554921 TLR2 in conjunction with TLR6, and possibly other TLRs, is essential for the recognition of lipoproteins and peptidoglycan molecules found on pathogens such as Gram-negative bacteria, Gram-positive bacteria, mycobacteria, spirochetes, and zymozan from fungi.

Go back
743.0, 681.0
23.0, 23.0

p100

p100

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038724 e103

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c264 : 1
stoichiometry:c262 : 1

m16910*m108*0.1

nodelay

--

true

0

false

PMID: 12213596, 10626894, 10848580 Another putative target of PKR is the IKKbeta subunit of the IKK complex that physically associates with PKR [20] and is believed to mediate the NF-kappaB activation in a manner that is independent of PKR kinase activity.

Go back
1350.0, 562.0
27.0, 27.0

p101

p101

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e88 MO000016916

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c269 : 1
stoichiometry:c270 : 1

m91*m1831*0.1

nodelay

--

true

0

false

PMID: 12213596 Components of bacterial cell wall, such as LPS, activate TLR4 signaling, leading to cytokine production through the activation of JNK/p38 and IKK complex.

Go back
1374.0, 634.0
27.0, 27.0

p102

p102

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e88 MO000019005

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c266 : 1
stoichiometry:c271 : 1
stoichiometry:c272 : 1

m91*m3613*0.1

nodelay

--

true

0

false

PMID: 12213596 Components of bacterial cell wall, such as LPS, activate TLR4 signaling, leading to cytokine production through the activation of JNK/p38 and IKK complex.

Go back
448.0, 1156.0
23.0, 23.0

p42

p103

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e67 e100

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c276 : 1
stoichiometry:c274 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 12213596, 9566918, 9463386, 10082512 In addition, IRF-3 C-terminal phosphorylation is required for association with the histone acetyltransferase nuclear proteins CBP and p300 [10, 13 and 23] causing IRF-3, which normally shuttles into and out of the nucleus, to become predominantly nuclear. PMID: 12213596 DNA-PK phosphorylates Thr 135 near the nuclear export sequence and may inhibit export of IRF-3 from the nucleus.

Go back
152.0, 1432.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 e34

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c47 : 1
stoichiometry:c28 : 1

m11*m37*0.1

nodelay

--

true

0

false

PMID: 12213596, 11554921 TLR2 in conjunction with TLR6, and possibly other TLRs, is essential for the recognition of lipoproteins and peptidoglycan molecules found on pathogens such as Gram-negative bacteria, Gram-positive bacteria, mycobacteria, spirochetes, and zymozan from fungi.

Go back
151.0, 1510.0
23.0, 23.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 e35

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c48 : 1
stoichiometry:c30 : 1

m11*m38*0.1

nodelay

--

true

0

false

PMID: 12213596, 11554921 TLR2 in conjunction with TLR6, and possibly other TLRs, is essential for the recognition of lipoproteins and peptidoglycan molecules found on pathogens such as Gram-negative bacteria, Gram-positive bacteria, mycobacteria, spirochetes, and zymozan from fungi.

Go back
158.0, 645.0
25.0, 25.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c32 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 12213596, 11607032 TLR3 is associated with the binding and activation of dsRNA signaling.

Go back
139.0, 1646.0
23.0, 23.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 MO000022185

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 12213596, 11554921 TLR5 is responsible for the recognition of flagellin, a monomeric constituent of bacterial flagella.

Go back
153.0, 1756.0
25.0, 25.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m19828*m32*0.1

nodelay

--

true

0

false

PMID: 12213596, 11554921, 11470918 TLR9 is essential for the recognition of bacterial CpG DNA, a motif found in non-methylated bacterial DNA.

Go back
782.0, 192.0
25.0, 25.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e31 MO000019395

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m34*m3962*0.1

nodelay

--

true

0

false

PMID: 12213596 Activated TLRs associate with a cytoplasmic adapter molecule, MyD88, through the homophilic interaction between their TIR domains.

Go back
784.0, 334.0
21.0, 21.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e32 MO000016573

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m35*m1572*0.1

nodelay

--

true

0

false

PMID: 12213596 Activated TLRs associate with a cytoplasmic adapter molecule, MyD88, through the homophilic interaction between their TIR domains.

Go back
846.0, 340.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e33 MO000000213

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m36*m184*0.1

nodelay

--

true

0

false

PMID: 12213596 MyD88 interacts with the Ser/Thr kinase IRAK which subsequently activates the TRAF6 adapter.

Go back
923.0, 353.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 MO000000212

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c53 : 1

m39*m183*0.1

nodelay

--

true

0

false

PMID: 12213596 MyD88 interacts with the Ser/Thr kinase IRAK which subsequently activates the TRAF6 adapter.

Go back
1109.0, 1215.0
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007758 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m991*m17*0.1

nodelay

--

true

0

false

PMID: 12213596, 11585785, 11544356 STAT1/2 heterodimers, in conjunction with interferon-stimulated gene factor 3gamma (ISGF3gamma/IRF-9) bind to ISRE found in numerous IFN-induced genes, such as 2¡ì?5¡ì oligoadenylate synthase and the dsRNA activated kinase (PKR), resulting in the induction of proteins which impair viral gene expression and replication [2 and 3].

Go back
1038.0, 132.0
25.0, 25.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 12213596 MyD88 interacts with the Ser/Thr kinase IRAK which subsequently activates the TRAF6 adapter.

Go back
854.0, 544.0
25.0, 25.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e6 e38

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c65 : 1
stoichiometry:c64 : 1

m6*m41*0.1

nodelay

--

true

0

false

PMID: 12213596 TRAF6 in turn activates the stress-related MAPK pathways JNK and p38, as well as the IKK complex leading to AP-1 and NF-kappaB activation respectively, and the induction of cytokines such as TNF-alpha and IL-6. PMID: 11213596 The rate limiting step in this process is the activation of the IKK complex, which is composed of two catalytic subunits¡½IKKalpha and IKKbeta and one regulatory subunit IKKgamma.

Go back
1045.0, 559.0
27.0, 27.0

p22

p22

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 e38

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c61 : 1
stoichiometry:c58 : 1

m20*m41*0.1

nodelay

--

true

0

false

PMID: 12213596 TRAF6 in turn activates the stress-related MAPK pathways JNK and p38, as well as the IKK complex leading to AP-1 and NF-kappaB activation respectively, and the induction of cytokines such as TNF-alpha and IL-6.

Go back
951.0, 561.0
23.0, 23.0

p23

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000023 e38

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c62 : 1
stoichiometry:c60 : 1

m21*m41*0.1

nodelay

--

true

0

false

PMID: 12213596 TRAF6 in turn activates the stress-related MAPK pathways JNK and p38, as well as the IKK complex leading to AP-1 and NF-kappaB activation respectively, and the induction of cytokines such as TNF-alpha and IL-6.

Go back
896.0, 1140.0
23.0, 23.0

p24

p24

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e40 e104

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c275 : 1
stoichiometry:c273 : 1

m43*m109*0.1

nodelay

--

true

0

false

PMID: 12213596 Virus infection results in the activation of multiple signaling cascades resulting in the phosphorylation of ATF-2, C-Jun, IRF-3, and NF-kapppaB. PMID: 12213596 Following virus replication, the generation of dsRNA activates the stress-induced MAPK pathway p38/JNK resulting in the AP-1 activation. PMID: 12213596 The heterodimers ATF-2/c-Jun are expressed as nuclear proteins that are activated by phosphorylation of their activation domains by p38/JNK.

Go back
773.0, 1081.0
22.0, 22.0

p25

p25

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e96 e104

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m101*m109*0.1

nodelay

--

true

0

false

PMID: 12213596 Virus infection results in the activation of multiple signaling cascades resulting in the phosphorylation of ATF-2, C-Jun, IRF-3, and NF-kapppaB. PMID: 12213596 Following virus replication, the generation of dsRNA activates the stress-induced MAPK pathway p38/JNK resulting in the AP-1 activation. PMID: 12213596 The heterodimers ATF-2/c-Jun are expressed as nuclear proteins that are activated by phosphorylation of their activation domains by p38/JNK. PMID: 12213596, 10747925 In addition, a small molecule CG18 that stimulates MEKK1 activity activated the stress-mediated signaling pathway and stimulated the formation of the IFN-beta enhanceosome [48], including the activation of ATF-2/c-Jun, IRF-3, and NF-kappaB.

Go back
807.0, 661.0
23.0, 23.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e41 MO000038724

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m44*m16910*0.1

nodelay

--

true

0

false

PMID: 1213596 The NF-kappaB factors are retained in the cytoplasm of non-stimulated cells in association with inhibitory subunits¡½inhibitors kappa B (I¦ÊBs); dsRNA- and virus-induced phosphorylation at conserved N-terminal residues (Ser 32 and 36) of IkappaB-alpha is accomplished by the I¦ÊB kinase (IKK) complex. PMID: 12213596, 10837071 Phosphorylation triggers a signal that induces ubiquitin-dependent, proteasome-mediated degradation of IkappaB-alpha, and subsequent nuclear translocation of the NF-kappaB dimers. PMID: 12213596, 10626894, 10848580 Another putative target of PKR is the IKKbeta subunit of the IKK complex that physically associates with PKR [20] and is believed to mediate the NF-kappaB activation in a manner that is independent of PKR kinase activity. PMID: 12213596, 11607032 Activation of TLR-3 induces the activation of both MAPK and NF-kappaB pathways, independently of the adapter protein MyD88. PMID: 12213596 These experiments imply that MEKK1 can induce IRF-3 and ATF2/c-Jun through the JNK pathway and NF-kappaB through the IKK pathway, resulting in the integration of multiple signal transduction pathways leading to the proper assembly of the IFN-beta enhanceosome.

Go back
737.0, 843.0
27.0, 27.0

p27

p27

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e45

MO000016632 MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c76 : 1
stoichiometry:c83 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 12213596, 10837071 Phosphorylation triggers a signal that induces ubiquitin-dependent, proteasome-mediated degradation of IkappaB-alpha, and subsequent nuclear translocation of the NF-kappaB dimers. PMID: 12213596, 10626894, 10848580 Another putative target of PKR is the IKKbeta subunit of the IKK complex that physically associates with PKR [20] and is believed to mediate the NF-kappaB activation in a manner that is independent of PKR kinase activity. PMID: 12213596, 11607032 Activation of TLR-3 induces the activation of both MAPK and NF-kappaB pathways, independently of the adapter protein MyD88. PMID: 12213596 These experiments imply that MEKK1 can induce IRF-3 and ATF2/c-Jun through the JNK pathway and NF-kappaB through the IKK pathway, resulting in the integration of multiple signal transduction pathways leading to the proper assembly of the IFN-beta enhanceosome.

Go back
737.0, 1024.0
27.0, 27.0

p28

p28

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000016632

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m1617*0.1

nodelay

--

true

0

false

PMID: 12213596, 10837071 Phosphorylation triggers a signal that induces ubiquitin-dependent, proteasome-mediated degradation of IkappaB-alpha, and subsequent nuclear translocation of the NF-kappaB dimers.

Go back
736.0, 1284.0
23.0, 23.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c77 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 12213596 TRAF6 in turn activates the stress-related MAPK pathways JNK and p38, as well as the IKK complex leading to AP-1 and NF-kappaB activation respectively, and the induction of cytokines such as TNF-alpha and IL-6.

Go back
1107.0, 1074.0
23.0, 23.0

p3

p3

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 12213596, 11585785, 11544356 STAT1/2 heterodimers, in conjunction with interferon-stimulated gene factor 3gamma (ISGF3gamma/IRF-9) bind to ISRE found in numerous IFN-induced genes, such as 2¡ì?5¡ì oligoadenylate synthase and the dsRNA activated kinase (PKR), resulting in the induction of proteins which impair viral gene expression and replication [2 and 3].

Go back
812.0, 1300.0
23.0, 23.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 12213596 TRAF6 in turn activates the stress-related MAPK pathways JNK and p38, as well as the IKK complex leading to AP-1 and NF-kappaB activation respectively, and the induction of cytokines such as TNF-alpha and IL-6.

Go back
807.0, 789.0
23.0, 23.0

p31

p31

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000000254

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c84 : 1

m208*0.1

nodelay

--

true

0

false

PMID: 12213596, 10837071 Phosphorylation triggers a signal that induces ubiquitin-dependent, proteasome-mediated degradation of IkappaB-alpha, and subsequent nuclear translocation of the NF-kappaB dimers. PMID: 12213596, 10626894, 10848580 Another putative target of PKR is the IKKbeta subunit of the IKK complex that physically associates with PKR [20] and is believed to mediate the NF-kappaB activation in a manner that is independent of PKR kinase activity. PMID: 12213596, 11607032 Activation of TLR-3 induces the activation of both MAPK and NF-kappaB pathways, independently of the adapter protein MyD88. PMID: 12213596 These experiments imply that MEKK1 can induce IRF-3 and ATF2/c-Jun through the JNK pathway and NF-kappaB through the IKK pathway, resulting in the integration of multiple signal transduction pathways leading to the proper assembly of the IFN-beta enhanceosome.

Go back
851.0, 1195.0
25.0, 25.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000276 e105 e106

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c89 : 1
stoichiometry:c88 : 1
stoichiometry:c87 : 1

m219*m46*m110*0.1

nodelay

--

true

0

false

PMID: 12213596 Following virus replication, the generation of dsRNA activates the stress-induced MAPK pathway p38/JNK resulting in the AP-1 activation. PMID: 12213596 The heterodimers ATF-2/c-Jun are expressed as nuclear proteins that are activated by phosphorylation of their activation domains by p38/JNK.

Go back
768.0, 1300.0
23.0, 23.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e46

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c92 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 12213596 TRAF6 in turn activates the stress-related MAPK pathways JNK and p38, as well as the IKK complex leading to AP-1 and NF-kappaB activation respectively, and the induction of cytokines such as TNF-alpha and IL-6.

Go back
856.0, 1300.0
23.0, 23.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e46

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c93 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 12213596 TRAF6 in turn activates the stress-related MAPK pathways JNK and p38, as well as the IKK complex leading to AP-1 and NF-kappaB activation respectively, and the induction of cytokines such as TNF-alpha and IL-6.

Go back
134.0, 712.0
25.0, 25.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e47 MO000019398

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m63*m3965*0.1

nodelay

--

true

0

false

PMID: 12213596 The dsRNA mimetic poly(I:C) has the capacity to induce a subset of ISGs and cytokines that function to impede viral replication.

Go back
447.0, 1301.0
23.0, 23.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e48

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c245 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 12213596 The dsRNA mimetic poly(I:C) has the capacity to induce a subset of ISGs and cytokines that function to impede viral replication.

Go back
475.0, 1241.0
23.0, 23.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e48

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c99 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 12213596 The dsRNA mimetic poly(I:C) has the capacity to induce a subset of ISGs and cytokines that function to impede viral replication.

Go back
397.0, 712.0
27.0, 27.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e78

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c160 : 1
stoichiometry:c102 : 1

m977*m81*0.1

nodelay

--

true

0

false

PMID: 12213596, 11401490 Indeed, PACT, a dsRNA-binding protein originally identified as an activator of PKR, was shown to enhance IRF-3 activation.

Go back
401.0, 764.0
27.0, 27.0

p39

p39

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e73

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c103 : 1
stoichiometry:c105 : 1

m977*m76*0.1

nodelay

--

true

0

false

PMID: 12213596 Viral nucleocapsid (N) and dsRNA activate VAK, a virus activated kinase, leading to C-terminal phosphorylation of IRF-3. PMID: 12213596 Virus-mediated activation of IRF-3 through VAK is dependent on viral entry and transcription, since replication deficient virus failed to induce IRF-3 activity. PMID: 12213596, 11907205 Indeed, a recent study has shown that the N nucleocapsid (N) protein of MeV induced IRF-3 activation via the induction of VAK.

Go back
888.0, 1408.0
23.0, 23.0

p4

p4

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e19 e18

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m22*m19*0.1

nodelay

--

true

0

false

PMID: 12213596, 11585785, 11544356 STAT1/2 heterodimers, in conjunction with interferon-stimulated gene factor 3gamma (ISGF3gamma/IRF-9) bind to ISRE found in numerous IFN-induced genes, such as 2¡ì?5¡ì oligoadenylate synthase and the dsRNA activated kinase (PKR), resulting in the induction of proteins which impair viral gene expression and replication [2 and 3].

Go back
498.0, 880.0
25.0, 25.0

p40

p40

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 12213596 IRF-3 C-terminal phosphorylation results in homodimerization, accumulation in the nucleus through CBP association, activation of genes through DNA binding and degradation by the proteasome pathway.

Go back
499.0, 981.0
23.0, 23.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e64 e66

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c109 : 1

m67*m69*0.1

nodelay

--

true

0

false

PMID: 12213596, 9566918, 9463386, 10082512 In addition, IRF-3 C-terminal phosphorylation is required for association with the histone acetyltransferase nuclear proteins CBP and p300 [10, 13 and 23] causing IRF-3, which normally shuttles into and out of the nucleus, to become predominantly nuclear. PMID: 12213596, 11035028 Indeed, as opposed to the observation made by Kim¡Çs group, stress-inducers and DNA damaging agents failed to induce nuclear accumulation through CBP association or transcriptional activation of RANTES promoter.

Go back
591.0, 1117.0
23.0, 23.0

p42

p42

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e65

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 12213596, 9566918, 9463386, 10082512 In addition, IRF-3 C-terminal phosphorylation is required for association with the histone acetyltransferase nuclear proteins CBP and p300 [10, 13 and 23] causing IRF-3, which normally shuttles into and out of the nucleus, to become predominantly nuclear. PMID: 12213596, 11035028 Indeed, as opposed to the observation made by Kim¡Çs group, stress-inducers and DNA damaging agents failed to induce nuclear accumulation through CBP association or transcriptional activation of RANTES promoter.

Go back
488.0, 1374.0
21.0, 21.0

p43

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e68

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c116 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 12213596 Genes targeted by IRF-3 include not only the classical IRF-responsive genes IFNalpha1 and beta but also new candidates such as genes encoding for the chemokine RANTES and the cytokine IL-15.

Go back
536.0, 1270.0
21.0, 21.0

p44

p44

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e67 e18

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m70*m19*0.1

nodelay

--

true

0

false

PMID: 12213596, 9566918, 9660935, 9463386 The activated form of IRF-3, bound to CBP, induces transcription through distinct positive regulatory domains in the type 1 IFN promoters, and through select ISRE sites.

Go back
516.0, 1391.0
21.0, 21.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e68

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c117 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 12213596 Genes targeted by IRF-3 include not only the classical IRF-responsive genes IFNalpha1 and beta but also new candidates such as genes encoding for the chemokine RANTES and the cytokine IL-15. PMID: 12213596, 10678979, 11896392 Treatment of murine macrophages with LPS also induces the production of IFNbeta, suggesting the activation of some IRF members by LPS [4 and 5] and also implying a role for ISGs in response to bacterial infection.

Go back
551.0, 1426.0
23.0, 23.0

p46

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e68

G010522

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c118 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 12213596 Genes targeted by IRF-3 include not only the classical IRF-responsive genes IFNalpha1 and beta but also new candidates such as genes encoding for the chemokine RANTES and the cytokine IL-15. PMID: 12213596, 11035028 Indeed, as opposed to the observation made by Kim¡Çs group, stress-inducers and DNA damaging agents failed to induce nuclear accumulation through CBP association or transcriptional activation of RANTES promoter.

Go back
583.0, 1458.0
23.0, 23.0

p47

p47

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e68

G012390

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c122 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 12213596 Genes targeted by IRF-3 include not only the classical IRF-responsive genes IFNalpha1 and beta but also new candidates such as genes encoding for the chemokine RANTES and the cytokine IL-15.

Go back
640.0, 1479.0
21.0, 21.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c124 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 12213596 Recently, the IFN-stimulated gene ISG56 was shown to be a direct target of IRF-3.

Go back
1055.0, 1146.0
23.0, 23.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e70 MO000007758

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1

m73*m991*0.1

nodelay

--

true

0

false

PMID: 12213596, 11118224 Interestingly, ISG56 acts as an inhibitor of cell proliferation by downregulating protein synthesis through interaction with the p48 subunit of eIF-3.

Go back
1108.0, 1400.0
23.0, 23.0

p5

p5

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e17

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 12213596, 11585785, 11544356 STAT1/2 heterodimers, in conjunction with interferon-stimulated gene factor 3gamma (ISGF3gamma/IRF-9) bind to ISRE found in numerous IFN-induced genes, such as 2¡ì?5¡ì oligoadenylate synthase and the dsRNA activated kinase (PKR), resulting in the induction of proteins which impair viral gene expression and replication [2 and 3].

Go back
1306.0, 1289.0
25.0, 25.0

p50

p50

cso30:i:CE_CellProliferation

cso30:i:CC_Extracellular

--

e71

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 12213596, 11118224 Interestingly, ISG56 acts as an inhibitor of cell proliferation by downregulating protein synthesis through interaction with the p48 subunit of eIF-3.

Go back
1293.0, 1187.0
29.0, 29.0

p51

p51

cso30:i:CE_CellDeath

cso30:i:CC_Extracellular

--

e70

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1

m73*0.1

nodelay

--

true

0

false

PMID: 12213596, 11118224 Thus, the translation inhibitory function of ISG56 may provide, at least in part, a mechanistic explanation for the ability of IRF-3 5D to mediate apoptosis.

Go back
1011.0, 1538.0
23.0, 23.0

p52

p52

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c131 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 12213596, 11118224 Thus, the translation inhibitory function of ISG56 may provide, at least in part, a mechanistic explanation for the ability of IRF-3 5D to mediate apoptosis.

Go back
329.0, 672.0
27.0, 27.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e72 MO000041446

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c135 : 1
stoichiometry:c134 : 1

m75*m19314*0.1

nodelay

--

true

0

false

PMID: 12213596 Virus-mediated activation of IRF-3 through VAK is dependent on viral entry and transcription, since replication deficient virus failed to induce IRF-3 activity.

Go back
1236.0, 438.0
23.0, 23.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016917 MO000041446

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c144 : 1
stoichiometry:c137 : 1

m1832*m19314*0.1

nodelay

--

true

0

false

PMID: 12213596 Following virus replication, the generation of dsRNA activates the stress-induced MAPK pathway p38/JNK resulting in the AP-1 activation. PMID: 12213596, 10626894, 10611240, 11846975 Virus infection or dsRNA treatment leads to the activation of the stress-activated members of the MAP kinase (MAP K) superfamily, namely the c-Jun amino terminal kinases (JNKs) and p38 proteins which are downstream of well defined stress-activated kinase cascades comprised of MKK4,7 and MKK3,6 respectively.

Go back
1260.0, 600.0
24.0, 24.0

p55

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000016916 MO000041446

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c267 : 1
stoichiometry:c139 : 1

m1831*m19314*0.1

nodelay

--

true

0

false

PMID: 12213596 Following virus replication, the generation of dsRNA activates the stress-induced MAPK pathway p38/JNK resulting in the AP-1 activation. PMID: 12213596, 10626894, 10611240, 11846975 Virus infection or dsRNA treatment leads to the activation of the stress-activated members of the MAP kinase (MAP K) superfamily, namely the c-Jun amino terminal kinases (JNKs) and p38 proteins which are downstream of well defined stress-activated kinase cascades comprised of MKK4,7 and MKK3,6 respectively. PMID: 12213596 Components of bacterial cell wall, such as LPS, activate TLR4 signaling, leading to cytokine production through the activation of JNK/p38 and IKK complex.

Go back
1238.0, 516.0
25.0, 25.0

p56

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000016966 MO000041446

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c145 : 1
stoichiometry:c141 : 1

m1875*m19314*0.1

nodelay

--

true

0

false

PMID: 12213596 Following virus replication, the generation of dsRNA activates the stress-induced MAPK pathway p38/JNK resulting in the AP-1 activation. PMID: 12213596, 10626894, 10611240, 11846975 Virus infection or dsRNA treatment leads to the activation of the stress-activated members of the MAP kinase (MAP K) superfamily, namely the c-Jun amino terminal kinases (JNKs) and p38 proteins which are downstream of well defined stress-activated kinase cascades comprised of MKK4,7 and MKK3,6 respectively.

Go back
1287.0, 667.0
25.5, 25.5

p57

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000019005 MO000041446

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c268 : 1
stoichiometry:c143 : 1

m3613*m19314*0.1

nodelay

--

true

0

false

PMID: 12213596 Following virus replication, the generation of dsRNA activates the stress-induced MAPK pathway p38/JNK resulting in the AP-1 activation. PMID: 12213596, 10626894, 10611240, 11846975 Virus infection or dsRNA treatment leads to the activation of the stress-activated members of the MAP kinase (MAP K) superfamily, namely the c-Jun amino terminal kinases (JNKs) and p38 proteins which are downstream of well defined stress-activated kinase cascades comprised of MKK4,7 and MKK3,6 respectively. PMID: 12213596 Components of bacterial cell wall, such as LPS, activate TLR4 signaling, leading to cytokine production through the activation of JNK/p38 and IKK complex.

Go back
955.0, 617.0
23.0, 23.0

p58

p58

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000023 e77 e74

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c154 : 1
stoichiometry:c146 : 1
stoichiometry:c238 : 1

m21*m80*m77*0.1

nodelay

--

true

0

false

PMID: 12213596 Following virus replication, the generation of dsRNA activates the stress-induced MAPK pathway p38/JNK resulting in the AP-1 activation. PMID: 12213596, 10626894, 10611240, 11846975 Virus infection or dsRNA treatment leads to the activation of the stress-activated members of the MAP kinase (MAP K) superfamily, namely the c-Jun amino terminal kinases (JNKs) and p38 proteins which are downstream of well defined stress-activated kinase cascades comprised of MKK4,7 and MKK3,6 respectively. PMID: 12213596 Components of bacterial cell wall, such as LPS, activate TLR4 signaling, leading to cytokine production through the activation of JNK/p38 and IKK complex.

Go back
230.0, 593.0
25.0, 25.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000022224 MO000022533

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1
stoichiometry:c156 : 1

m119368*m6814*0.1

nodelay

--

true

0

false

PMID: 12213596, 11401490 Indeed, PACT, a dsRNA-binding protein originally identified as an activator of PKR, was shown to enhance IRF-3 activation.

Go back
837.0, 1469.0
21.0, 21.0

p6

p6

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c16 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 12213596, 11585785, 11544356 STAT1/2 heterodimers, in conjunction with interferon-stimulated gene factor 3gamma (ISGF3gamma/IRF-9) bind to ISRE found in numerous IFN-induced genes, such as 2¡ì?5¡ì oligoadenylate synthase and the dsRNA activated kinase (PKR), resulting in the induction of proteins which impair viral gene expression and replication [2 and 3]. PMID: 12213596, 11585785 The intracellular target of dsRNA is PKR, a Ser/Thr kinase that is induced by IFNs and activated catalytically through the binding of dsRNA.

Go back
1046.0, 604.0
25.0, 25.0

p60

p60

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 e75 e76

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c155 : 1
stoichiometry:c147 : 1
stoichiometry:c149 : 1

m20*m78*m79*0.1

nodelay

--

true

0

false

PMID: 12213596 Following virus replication, the generation of dsRNA activates the stress-induced MAPK pathway p38/JNK resulting in the AP-1 activation. PMID: 12213596, 10626894, 10611240, 11846975 Virus infection or dsRNA treatment leads to the activation of the stress-activated members of the MAP kinase (MAP K) superfamily, namely the c-Jun amino terminal kinases (JNKs) and p38 proteins which are downstream of well defined stress-activated kinase cascades comprised of MKK4,7 and MKK3,6 respectively. PMID: 12213596 Components of bacterial cell wall, such as LPS, activate TLR4 signaling, leading to cytokine production through the activation of JNK/p38 and IKK complex.

Go back
399.0, 593.0
23.0, 23.0

p61

p61

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000008179 e78

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c159 : 1
stoichiometry:c158 : 1

m1055*m81*0.1

nodelay

--

true

0

false

PMID: 12213596, 11401490 Indeed, PACT, a dsRNA-binding protein originally identified as an activator of PKR, was shown to enhance IRF-3 activation.

Go back
247.0, 881.0
23.0, 23.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e79 MO000007694

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m82*m977*0.1

nodelay

--

true

0

false

PMID: 12213596 Interestingly, N protein physically interacts with IRF-3, implying that IRF-3 itself represents the molecule that detects the viral pathogen via nucleocapsid recognition.

Go back
242.0, 832.0
25.0, 25.0

p63

p63

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e72 e79

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c166 : 1
stoichiometry:c165 : 1

m75*m82*0.1

nodelay

--

true

0

false

PMID: 12213596, 11907205 Indeed, a recent study has shown that the N nucleocapsid (N) protein of MeV induced IRF-3 activation via the induction of VAK.

Go back
399.0, 517.0
23.0, 23.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000008179

MO000022225

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m119368*m1055*0.1

nodelay

--

true

0

false

PMID: 12213596 Following interaction with dsRNA, PKR becomes autophosphorylated and, in turn, phosphorylates a restricted number of substrates, the best characterized of which is the ¦Á subunit of eukaryotic protein synthesis initiation factor 2 (eIF2alpha).

Go back
400.0, 556.0
23.0, 23.0

p65

p65

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

MO000022225

e13 MO000022224

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m6524*0.1

nodelay

--

true

0

false

PMID: 12213596 Following interaction with dsRNA, PKR becomes autophosphorylated and, in turn, phosphorylates a restricted number of substrates, the best characterized of which is the alpha subunit of eukaryotic protein synthesis initiation factor 2 (eIF2alpha).

Go back
542.0, 684.0
25.0, 25.0

p66

p66

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000022570 e13

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c175 : 1
stoichiometry:c174 : 1

m6843*m14*0.1

nodelay

--

true

0

false

PMID: 12213596 Following interaction with dsRNA, PKR becomes autophosphorylated and, in turn, phosphorylates a restricted number of substrates, the best characterized of which is the alpha subunit of eukaryotic protein synthesis initiation factor 2 (eIF2alpha).

Go back
607.0, 749.0
23.0, 23.0

p67

p67

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000068430 e81

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c178 : 1
stoichiometry:c177 : 1

m43278*0.1

nodelay

--

true

0

false

PMID: 12213596, 11585785 Phosphorylation of eIF2alpha on Ser 51 causes a dramatic inhibition of protein synthesis by sequestering the guanine nucleotide exchange factor eIF2B, a rate-limiting component of the translation machinery.

Go back
541.0, 880.0
27.0, 27.0

p68

p68

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e81

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 12213596, 11585785 Phosphorylation of eIF2alpha on Ser 51 causes a dramatic inhibition of protein synthesis by sequestering the guanine nucleotide exchange factor eIF2B, a rate-limiting component of the translation machinery.

Go back
607.0, 545.0
23.0, 23.0

p69

p69

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 e6

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m14*m6*0.1

nodelay

--

true

0

false

PMID: 12213596, 10626894, 10848580 Another putative target of PKR is the IKKbeta subunit of the IKK complex that physically associates with PKR [20] and is believed to mediate the NF-kappaB activation in a manner that is independent of PKR kinase activity.

Go back
841.0, 1505.0
21.0, 21.0

p7

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20

G010199

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c17 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 12213596, 11585785, 11544356 STAT1/2 heterodimers, in conjunction with interferon-stimulated gene factor 3gamma (ISGF3gamma/IRF-9) bind to ISRE found in numerous IFN-induced genes, such as 2¡ì?5¡ì oligoadenylate synthase and the dsRNA activated kinase (PKR), resulting in the induction of proteins which impair viral gene expression and replication [2 and 3].

Go back
667.0, 629.0
23.0, 23.0

p70

p70

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e83

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c184 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 12213596, 10626894, 10848580 Another putative target of PKR is the IKKbeta subunit of the IKK complex that physically associates with PKR [20] and is believed to mediate the NF-kappaB activation in a manner that is independent of PKR kinase activity.

Go back
731.0, 589.0
23.0, 23.0

p71

p71

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e6 MO000041446

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c188 : 1
stoichiometry:c187 : 1

m6*m19314*0.1

nodelay

--

true

0

false

PMID: 12213596, 11607032 Activation of TLR-3 induces the activation of both MAPK and NF-kappaB pathways, independently of the adapter protein MyD88.

Go back
911.0, 1303.0
25.0, 25.0

p72

p72

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c189 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 12213596, 11477402, 11191641 Indeed, following PAMP interaction with the TLRs, the IKK and JNK/p38 pathways are activated resulting in the activation of NF-kappaB and AP-1 transcription factors which ultimately lead to cytokine production.

Go back
956.0, 1304.0
23.0, 23.0

p73

p73

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e46

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c190 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 12213596, 11477402, 11191641 Indeed, following PAMP interaction with the TLRs, the IKK and JNK/p38 pathways are activated resulting in the activation of NF-kappaB and AP-1 transcription factors which ultimately lead to cytokine production.

Go back
1035.0, 1446.0
23.0, 23.0

p74

p74

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e84

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c193 : 1

m87*0.1

nodelay

--

true

0

false

PMID: 12213596, 11477402, 11191641 Indeed, following PAMP interaction with the TLRs, the IKK and JNK/p38 pathways are activated resulting in the activation of NF-kappaB and AP-1 transcription factors which ultimately lead to cytokine production.

Go back
319.0, 346.0
23.0, 23.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000016573

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c197 : 1
stoichiometry:c196 : 1

m25*m1572*0.1

nodelay

--

true

0

false

PMID: 12213596 Activated TLRs associate with a cytoplasmic adapter molecule, MyD88, through the homophilic interaction between their TIR domains.

Go back
410.0, 344.0
25.0, 25.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e85 MO000000213

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c200 : 1
stoichiometry:c199 : 1

m88*m184*0.1

nodelay

--

true

0

false

PMID: 12213596 MyD88 interacts with the Ser/Thr kinase IRAK which subsequently activates the TRAF6 adapter.

Go back
464.0, 342.0
21.0, 21.0

p77

p77

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e86 MO000000212

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c203 : 1
stoichiometry:c202 : 1

m89*m183*0.1

nodelay

--

true

0

false

PMID: 12213596 MyD88 interacts with the Ser/Thr kinase IRAK which subsequently activates the TRAF6 adapter.

Go back
534.0, 197.0
25.0, 25.0

p78

p78

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e87

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 12213596 MyD88 interacts with the Ser/Thr kinase IRAK which subsequently activates the TRAF6 adapter.

Go back
1305.0, 396.0
27.0, 27.0

p79

p79

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016917 e88

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c210 : 1
stoichiometry:c207 : 1

m1832*m91*0.1

nodelay

--

true

0

false

PMID: 12213596 Components of bacterial cell wall, such as LPS, activate TLR4 signaling, leading to cytokine production through the activation of JNK/p38 and IKK complex.

Go back
318.0, 201.0
25.0, 25.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 12213596, 11191641 TLR4 is essential for the recognition of LPS, the major component of the outer membrane of Gram-negative bacteria.

Go back
1305.0, 476.0
27.0, 27.0

p80

p80

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000016966 e88

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c208 : 1
stoichiometry:c211 : 1
stoichiometry:c209 : 1

m1875*m91*0.1

nodelay

--

true

0

false

PMID: 12213596 Components of bacterial cell wall, such as LPS, activate TLR4 signaling, leading to cytokine production through the activation of JNK/p38 and IKK complex.

Go back
686.0, 524.0
25.0, 25.0

p81

p81

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e6 e88

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c214 : 1
stoichiometry:c213 : 1

m6*m91*0.1

nodelay

--

true

0

false

PMID: 12213596 Components of bacterial cell wall, such as LPS, activate TLR4 signaling, leading to cytokine production through the activation of JNK/p38 and IKK complex.

Go back
331.0, 429.0
23.0, 23.0

p82

p82

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000104 e22

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c219 : 1
stoichiometry:c216 : 1

m92*m25*0.1

nodelay

--

true

0

false

PMID: 12213596, 11477402 Treatment of target cells with LPS activates multiple signaling pathways in addition to IKK/JNK/p38, such as protein kinase C, Src-type tyrosine kinases, and the phosphatidylinositol 3-kinase-protein kinase B pathways.

Go back
363.0, 473.0
23.0, 23.0

p83

p83

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000136 e22

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c220 : 1
stoichiometry:c218 : 1

m122*m25*0.1

nodelay

--

true

0

false

PMID: 12213596, 11477402 Treatment of target cells with LPS activates multiple signaling pathways in addition to IKK/JNK/p38, such as protein kinase C, Src-type tyrosine kinases, and the phosphatidylinositol 3-kinase-protein kinase B pathways.

Go back
403.0, 473.0
23.0, 23.0

p84

p84

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017608 e22

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c223 : 1
stoichiometry:c222 : 1

m2387*m25*0.1

nodelay

--

true

0

false

PMID: 12213596, 11477402 Treatment of target cells with LPS activates multiple signaling pathways in addition to IKK/JNK/p38, such as protein kinase C, Src-type tyrosine kinases, and the phosphatidylinositol 3-kinase-protein kinase B pathways.

Go back
403.0, 797.0
23.0, 23.0

p85

p85

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e22 MO000007694

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c225 : 1
stoichiometry:c226 : 1

m25*m977*0.1

nodelay

--

true

0

false

PMID: 12213596, 11698465 Phosphorylation of IRF-3 in response to LPS was demonstrated by Akira¡Çs group. PMID: 12213596, 10678979, 11896392 Treatment of murine macrophages with LPS also induces the production of IFNbeta, suggesting the activation of some IRF members by LPS [4 and 5] and also implying a role for ISGs in response to bacterial infection. PMID: 1213596, 11854279 Another target gene, called UBP43 was also recently shown to be induced by LPS via IRF-3 in the murine macrophage-like cell line RAW 264.7.

Go back
604.0, 1370.0
21.0, 21.0

p86

p86

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e68

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c227 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 1213596, 11854279 Another target gene, called UBP43 was also recently shown to be induced by LPS via IRF-3 in the murine macrophage-like cell line RAW 264.7.

Go back
404.0, 846.0
23.0, 23.0

p87

p87

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e93

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c229 : 1
stoichiometry:c231 : 1
stoichiometry:c230 : 1

m977*m97*0.1

nodelay

--

true

0

false

PMID: 12213596, 11698465 Kim et al. [47] demonstrated that stress inducers and genotoxic agents such as DNA damaging agents doxorubicin and UV radiation stimulated IRF-3 phosphorylation, nuclear translocation, CBP association, and transcriptional activation of an IRF-3 responsive promoter. PMID: 12213596, 11035028 Phosphorylation of IRF-3 by the DNA damaging agent doxorubicin, by the osmotic shock inducer sorbitol, the stress inducer anisomycin, the phorbol ester PMA and overexpression of the MAP KKK family members MEKK1 and Cot has also been observed with phosphorylation occurring at the N-terminal end, between aa 186?198. PMID: 12213596, 11035028 Indeed, as opposed to the observation made by Kim¡Çs group, stress-inducers and DNA damaging agents failed to induce nuclear accumulation through CBP association or transcriptional activation of RANTES promoter.

Go back
851.0, 453.0
23.0, 23.0

p88

p88

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000047 e94

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c232 : 1
stoichiometry:c234 : 1
stoichiometry:c233 : 1

m99*m98*0.1

nodelay

--

true

0

false

PMID: 12213596, 10747925 In addition, a small molecule CG18 that stimulates MEKK1 activity activated the stress-mediated signaling pathway and stimulated the formation of the IFN-beta enhanceosome [48], including the activation of ATF-2/c-Jun, IRF-3, and NF-kappaB.

Go back
427.0, 693.0
23.0, 23.0

p89

p89

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e96

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c240 : 1
stoichiometry:c237 : 1

m977*m101*0.1

nodelay

--

true

0

false

PMID: 12213596, 10747925 In addition, a small molecule CG18 that stimulates MEKK1 activity activated the stress-mediated signaling pathway and stimulated the formation of the IFN-beta enhanceosome [48], including the activation of ATF-2/c-Jun, IRF-3, and NF-kappaB. PMID: 12213596 In these studies, MEKK1 activated IRF-3 through the JNK pathway but not through p38 or IKK pathways. PMID: 12213596, 10747925 However, the phosphorylation site(s) targeted by the MEKK1-related pathway are distinct from the C-terminal sites, since the IRF-3 (5A) protein, in which the five phosphoacceptor sites in the C-terminal end (Ser 396 to Ser 405) were mutated to alanine (see Fig. 2), was still phosphorylated in response to CG18 and MEKK1.

Go back
225.0, 296.0
27.0, 27.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

MO000018132 e23 MO000019394

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c25 : 1

m2828*m26*m3961*0.1

nodelay

--

true

0

false

PMID: 12213596, 11062499 The innate immune response to RSV is mediated by the interaction of fusion protein of RSV with TLR4 and CD-14.

Go back
947.0, 513.0
23.0, 23.0

p90

p90

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000023 e95

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c70 : 1
stoichiometry:c153 : 1

m21*m100*0.1

nodelay

--

true

0

false

PMID: 12213596, 10747925 In addition, a small molecule CG18 that stimulates MEKK1 activity activated the stress-mediated signaling pathway and stimulated the formation of the IFN-beta enhanceosome [48], including the activation of ATF-2/c-Jun, IRF-3, and NF-kappaB. PMID: 12213596 In these studies, MEKK1 activated IRF-3 through the JNK pathway but not through p38 or IKK pathways. PMID: 12213596 These experiments imply that MEKK1 can induce IRF-3 and ATF2/c-Jun through the JNK pathway and NF-kappaB through the IKK pathway, resulting in the integration of multiple signal transduction pathways leading to the proper assembly of the IFN-beta enhanceosome.

Go back
736.0, 486.0
21.0, 21.0

p91

p91

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e6 e95

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c243 : 1
stoichiometry:c242 : 1

m6*m100*0.1

nodelay

--

true

0

false

PMID: 12213596, 10747925 In addition, a small molecule CG18 that stimulates MEKK1 activity activated the stress-mediated signaling pathway and stimulated the formation of the IFN-beta enhanceosome [48], including the activation of ATF-2/c-Jun, IRF-3, and NF-kappaB. PMID: 12213596 These experiments imply that MEKK1 can induce IRF-3 and ATF2/c-Jun through the JNK pathway and NF-kappaB through the IKK pathway, resulting in the integration of multiple signal transduction pathways leading to the proper assembly of the IFN-beta enhanceosome.

Go back
885.0, 1081.0
21.0, 21.0

p92

p92

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e96 e104

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m101*m109*0.1

nodelay

--

true

0

false

PMID: 12213596 These experiments imply that MEKK1 can induce IRF-3 and ATF2/c-Jun through the JNK pathway and NF-kappaB through the IKK pathway, resulting in the integration of multiple signal transduction pathways leading to the proper assembly of the IFN-beta enhanceosome.

Go back
379.0, 909.0
23.0, 23.0

p93

p93

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e97

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c250 : 1
stoichiometry:c248 : 1

m977*m102*0.1

nodelay

--

true

0

false

PMID: 12213596, 11035028 Phosphorylation of IRF-3 by the DNA damaging agent doxorubicin, by the osmotic shock inducer sorbitol, the stress inducer anisomycin, the phorbol ester PMA and overexpression of the MAP KKK family members MEKK1 and Cot has also been observed with phosphorylation occurring at the N-terminal end, between aa 186?198. PMID: 12213596, 11035028 Indeed, as opposed to the observation made by Kim¡Çs group, stress-inducers and DNA damaging agents failed to induce nuclear accumulation through CBP association or transcriptional activation of RANTES promoter.

Go back
378.0, 940.0
25.0, 25.0

p94

p94

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000041456 e98

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c251 : 1

m19324*m103*0.1

nodelay

--

true

0

false

PMID: 12213596, 11035028 Phosphorylation of IRF-3 by the DNA damaging agent doxorubicin, by the osmotic shock inducer sorbitol, the stress inducer anisomycin, the phorbol ester PMA and overexpression of the MAP KKK family members MEKK1 and Cot has also been observed with phosphorylation occurring at the N-terminal end, between aa 186?198. PMID: 12213596, 11035028 Indeed, as opposed to the observation made by Kim¡Çs group, stress-inducers and DNA damaging agents failed to induce nuclear accumulation through CBP association or transcriptional activation of RANTES promoter.

Go back
379.0, 981.0
23.0, 23.0

p95

p95

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e99

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c254 : 1
stoichiometry:c253 : 1

m977*m104*0.1

nodelay

--

true

0

false

PMID: 12213596, 11035028 Phosphorylation of IRF-3 by the DNA damaging agent doxorubicin, by the osmotic shock inducer sorbitol, the stress inducer anisomycin, the phorbol ester PMA and overexpression of the MAP KKK family members MEKK1 and Cot has also been observed with phosphorylation occurring at the N-terminal end, between aa 186?198. PMID: 12213596, 11035028 Indeed, as opposed to the observation made by Kim¡Çs group, stress-inducers and DNA damaging agents failed to induce nuclear accumulation through CBP association or transcriptional activation of RANTES promoter.

Go back
376.0, 1026.0
21.0, 21.0

p96

p96

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e95

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c257 : 1
stoichiometry:c256 : 1

m977*m100*0.1

nodelay

--

true

0

false

PMID: 12213596, 11035028 Phosphorylation of IRF-3 by the DNA damaging agent doxorubicin, by the osmotic shock inducer sorbitol, the stress inducer anisomycin, the phorbol ester PMA and overexpression of the MAP KKK family members MEKK1 and Cot has also been observed with phosphorylation occurring at the N-terminal end, between aa 186?198. PMID: 12213596, 11035028 Indeed, as opposed to the observation made by Kim¡Çs group, stress-inducers and DNA damaging agents failed to induce nuclear accumulation through CBP association or transcriptional activation of RANTES promoter.

Go back
511.0, 1109.0
23.0, 23.0

p97

p97

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000018334

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c260 : 1
stoichiometry:c259 : 1

m977*m2978*0.1

nodelay

--

true

0

false

PMID: 12213596 DNA-PK phosphorylates Thr 135 near the nuclear export sequence and may inhibit export of IRF-3 from the nucleus.

Go back
716.0, 1514.0
21.0, 21.0

p99

p99

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e102

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c244 : 1

m107*0.1

nodelay

--

true

0

false

PMID: 12213596, 11698465 Recently, Akira¡Çs group observed induction of the IP-10 gene with lipid A, the functional moiety of LPS, in MyD88-deficient peritoneal macrophages in which production of TNF-alpha and IL-6 in response to LPS is completely impaired.

Go back
1292.0, 1086.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
972.0, 1412.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
19.156219072894373, 729.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
431.24477245946946, 735.3931212784858

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
423.0, 739.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
361.0, 779.1999375292817

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
435.99928898368967, 777.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
428.0, 786.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
511.0, 852.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
511.0, 905.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
511.0, 954.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
511.0, 1004.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
918.9195959492894, 1415.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
530.0, 993.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
528.0, 1063.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
603.0, 1140.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
563.5538553641524, 1253.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.1270256580369, 1289.633937983742

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
549.0, 1291.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
499.0, 1395.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
527.0, 1412.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
563.0, 1449.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
516.1203469188694, 1359.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
843.0, 1420.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
539.6690883852206, 1359.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
563.0, 1359.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
595.0, 1481.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.0, 1359.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
651.0, 1500.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
567.0, 1359.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1037.0, 1155.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1056.0, 1176.8303250020228

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1067.0, 1169.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1082.0, 1302.0

c129

c129

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
901.0, 1431.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1026.0, 1164.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1023.0, 1172.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.0, 1550.0

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
317.0, 705.9183115728807

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.0, 699.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
259.0, 662.0

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1127.0, 414.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1135.0, 450.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1133.0, 577.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1140.9990081824906, 612.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
865.5019900857897, 1466.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1129.0, 494.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1136.0, 529.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1131.0, 652.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1138.9993426188412, 680.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
179.50462128965546, 185.88410879693794

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
150.5003096297827, 161.5703824767985

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
972.2393381083772, 448.89054417822894

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1071.3370149585767, 542.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
924.0, 586.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.0, 617.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
867.4262408218646, 1466.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
129.0, 606.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
263.0, 606.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.0, 582.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
923.0963115579191, 536.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
978.553825469315, 646.5774367039918

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1078.9965420357148, 615.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
255.0, 610.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.9932582089723, 569.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
422.0, 613.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
411.0, 624.0

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
812.0, 1480.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
411.0, 686.0

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
187.0, 893.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.30531145503284, 784.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
270.0, 893.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
265.78754490716733, 752.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.0, 796.6800400983976

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
187.0, 856.0231486264291

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
129.0, 534.0076972702698

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.4087388781564, 536.0183750985082

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
422.0, 529.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.0, 1516.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
430.2325781320424, 537.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
423.0, 572.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
136.93777156944182, 570.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.0, 697.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.0, 709.0

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
500.0, 611.0

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
638.0, 761.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.0, 766.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.0, 759.0

c178

c178

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
555.0, 770.0

c179

c179

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
331.0, 153.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.0, 563.3947205962986

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
637.9710090382491, 542.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.0, 568.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
636.0, 643.0237707010416

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 638.796029752168

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
773.4732382146431, 699.854944935931

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
760.020613557655, 556.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
754.0, 601.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
259.0, 602.9093225628241

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
932.0, 1328.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
297.0, 233.39084770885086

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
959.9402850002907, 1327.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
882.0, 1264.0

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
768.0, 1236.0

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1058.0, 1458.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
964.0, 1372.0

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
331.0, 325.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
340.0, 322.3488508903353

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
330.89536483896717, 360.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
395.0, 317.0

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
423.0, 309.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1198.0, 1032.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
331.0, 226.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
423.02709984408256, 376.9999540997715

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
438.0, 301.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.0, 298.0

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
475.0169038039224, 370.99998214131836

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
493.0, 224.92216684322386

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.0, 222.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1127.0, 410.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1134.8579346928457, 413.0

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1129.0, 490.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1135.8563679957897, 493.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
239.0, 266.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 116.9537106803671

c210

c210

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
599.3114196294885, 96.50816044580816

c211

c211

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
718.9947793925485, 537.2889679298512

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
711.0, 543.0

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.0, 313.0

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
313.0, 414.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
321.0, 441.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
315.0, 485.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
326.02316458331507, 492.0

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
333.0, 325.0

c219

c219

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
114.0, 310.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
336.0, 325.0

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
415.0, 453.0

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.0, 485.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 325.0

c223

c223

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
86.89359405071127, 320.0

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
433.6376026758988, 782.0

c225

c225

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.0, 812.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
625.0, 1390.0

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.0, 1359.0

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
433.31929234671145, 790.0

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
260.0, 310.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
421.0, 869.0

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
69.0, 858.0716389185237

c231

c231

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
882.0, 465.0

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
863.0, 476.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.0, 465.27569820671823

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
911.515890117609, 627.0

c235

c235

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
455.9296349882005, 720.3702354610118

c236

c236

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
445.0, 716.0

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
939.0, 629.0

c238

c238

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
763.6287117495314, 508.4788592902239

c239

c239

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
187.0, 1342.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
457.9018181315364, 632.0

c240

c240

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
789.1700186486779, 641.0

c241

c241

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
755.0, 507.0

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
764.9541490951063, 498.85528484893615

c243

c243

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
715.8, 1508.4

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
470.0, 1314.0

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
896.3269992162815, 641.0

c246

c246

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
407.3117090530842, 793.0

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
402.0, 931.0

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.7488171341327, 851.0

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
239.0, 323.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
106.0, 921.0

c250

c250

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
105.0, 953.0

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
402.09444140075664, 793.0

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
402.0, 993.0

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
104.0, 993.0

c254

c254

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
396.614418356365, 793.0

c255

c255

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.0, 1005.7259714626609

c256

c256

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.9999999197664, 522.0

c257

c257

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
519.0, 793.0

c258

c258

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
533.0, 1132.0

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
179.0, 1350.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.5455043083341, 1086.0

c260

c260

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
766.0, 703.0

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
727.0, 1543.0

c263

c263

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
734.0, 655.0

c264

c264

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
606.0, 84.7025477771711

c265

c265

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
579.4550868670566, 68.61779432942913

c266

c266

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
139.50190688830548, 43.67463008903019

c267

c267

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
127.62527361529322, 4.203217280064564

c268

c268

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1133.0, 574.0

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
180.0075650887785, 1356.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1140.903574756855, 578.0

c270

c270

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1131.0, 648.0658413913775

c271

c271

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1138.9397218657714, 650.0

c272

c272

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
862.0, 1152.0

c273

c273

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
465.0, 1079.3531602401445

c274

c274

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
850.0, 1103.0

c275

c275

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.9953629893121, 1168.1925476139427

c276

c276

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
177.0, 1445.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
172.38823529411764, 1356.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1205.0, 1086.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.0, 1522.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
178.90984206778245, 677.4520345638331

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
183.0, 658.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
129.0, 619.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
168.98004812759777, 1610.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
151.0, 1615.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
162.0, 1658.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
184.74017719010317, 1722.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
166.0, 1721.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
178.0, 1769.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1068.0, 1226.1950639396377

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
795.0, 143.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
750.0, 224.07727008765872

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
795.0, 217.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
795.0, 310.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
754.0, 345.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
805.0, 308.24549324356997

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
109.0, 1342.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
120.0, 1442.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
118.0, 1522.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
859.0, 312.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1119.0, 1169.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
815.0, 362.0938134100054

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
871.0, 298.65685424949237

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
935.0, 300.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
942.0, 295.831526369483

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
904.0, 365.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1006.0, 164.25607174198745

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.0, 157.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1014.0, 573.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1026.897233121606, 585.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
924.0, 573.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1119.2498780190217, 1236.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
930.1758195855608, 584.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1052.0, 281.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
968.1468285180592, 281.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
828.0, 546.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
849.6839244307548, 569.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
879.1768457708087, 281.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
803.0, 1092.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.0, 1103.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
850.0, 1092.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
859.4057970281387, 1102.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1138.0, 1086.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
876.0, 511.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
924.0, 541.6568542494924

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.5689290811055, 621.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
833.0384156673698, 690.2140459897561

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.0, 684.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
819.0, 766.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
751.0, 870.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.0, 1307.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
751.1025556746006, 946.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
751.0, 1051.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1119.0, 1097.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
749.3995009355511, 1244.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
766.0, 1244.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
828.0, 1323.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
762.0, 870.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
819.0, 812.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
772.0, 857.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
884.0, 1208.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
865.0, 1220.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
847.0, 1169.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
798.0, 1175.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1119.0, 1313.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
797.7537025219824, 1265.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
868.0, 1270.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
762.7455923043988, 1323.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.159575575166, 1323.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
62.0, 725.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
147.0248262296831, 744.9999614785522

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
159.0, 725.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
478.13066005404005, 1177.6268012343824

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
7.389045542935946, 728.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
493.0, 1264.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back