1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/12773095.csml convertedTime:2009.07.01.10:41

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Principles of interleukin (IL)-6-type cytokine signalling and its regulation.
Authors Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F.
Affiliation Institut fur Biochemie, RWTH Aachen, Universitatsklinikum, Pauwelsstrasse 30,D-52074 Aachen, Germany. heinrich@rwth-aachen.de
Abstract The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitoryfactor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 andcardiotrophin-like cytokine are an important family of mediators involved in theregulation of the acute-phase response to injury and infection. Besides theirfunctions in inflammation and the immune response, these cytokines play also acrucial role in haematopoiesis, liver and neuronal regeneration, embryonaldevelopment and fertility. Dysregulation of IL-6-type cytokine signallingcontributes to the onset and maintenance of several diseases, such as rheumatoidarthritis, inflammatory bowel disease, osteoporosis, multiple sclerosis andvarious types of cancer (e.g. multiple myeloma and prostate cancer). IL-6-typecytokines exert their action via the signal transducers gp (glycoprotein) 130,LIF receptor and OSM receptor leading to the activation of the JAK/STAT (Januskinase/signal transducer and activator of transcription) and MAPK(mitogen-activated protein kinase) cascades. This review focuses on recentprogress in the understanding of the molecular mechanisms of IL-6-type cytokinesignal transduction. Emphasis is put on the termination and modulation of theJAK/STAT signalling pathway mediated by tyrosine phosphatases, the SOCS(suppressor of cytokine signalling) feedback inhibitors and PIAS (proteininhibitor of activated STAT) proteins. Also the cross-talk between the JAK/STATpathway with other signalling cascades is discussed.
PMID 12773095
Model Abstract

Entity

G010507:EpoR G011662:NMI G011948:SOCS3 G012485:OSMR MO000000011:ERK MO000000030:PI3K MO000000044:Vav MO000000048:AKT MO000000071:EGF MO000000092:EpoR MO000000098:PDGF MO000000145:Jak1 MO000000146:Jak2 MO000000148:Tyk2 MO000000154:IRS-1 MO000000289:TNF-alpha MO000003153:CNTF MO000003590:CT-1 MO000004676:ERK2 MO000006538:Hck MO000007384:IL-6 MO000008548:LIF MO000013119:STAT1{active} MO000013122:STAT3 MO000016665:IFNgamma MO000016777:Sos MO000016852:Pyk2{p} MO000016858:IRS-2 MO000016875:OSM MO000016876:STAT5 MO000016882:LPS MO000016894:MAPK MO000016917:MKK4 MO000016943:gp130 MO000016944:OSMR MO000016946:CNTFRalpha MO000016949:IL-11 MO000017004:SOCS-1 MO000017007:PIAS3 MO000017061:IL-2 MO000017065:PKCdelta MO000017066:Epo MO000017121:SOCS-3 MO000017277:Nmi MO000017526:caveolin-1 MO000017700:PIAS1 MO000017758:Cdk9 MO000018279:ErbB2 MO000018458:IL-6Ralpha MO000018946:elongin C MO000018966:OSMR:gp130 MO000018967:LIFR:gp130 MO000018968:CNTF:CNTFRalpha:LIFR:gp130 MO000019984:p300 MO000021135:Hsp90 MO000031185:SMRT MO000058820:IL-11Ralpha MO000066172:LEPR MO000089770:GCSFR MO000099682:CBP e1: e10: e100:STAT5:CBP e101:STAT3:p300 e102:STAT1:p300 e103:STAT5:p300 e104:STAT1:CBP:Nmi e105:STAT5:CBP:Nmi e106:SMRT:STAT5 e107:STAT3 e108:FKHR e109:STAT3:FKHR e11:CNTF:CNTFRalpha e110:mRNA e111:FKHR{p} e112:EZI e113:STAT3:EZI e114:Vav{active} e115:Rac-1 e116:Rac-1{active} e117:MKK4{active} e118:PKCdelta{active} e119:PKCdelta{active} e12:OSM:OSMR:gp130 e120:STAT3{p} e121:MAPK{active} e122:SOCS3:Ras e123:SOCS-3{p} e124:IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SHP2{p}:Gab1{p} e125:ERK2{active} e126:IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SHP2{p}:Gab1{p}:PI3K e127:PI3K:IRS-1 e128:STAT1:PIAS1 e129:DNA e13:OSM:LIFR:gp130 e130:STAT1:DNA e131:IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SOCS1 e132:EpoR:SOCS-3 e133:IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SOCS3 e134:LEPR:SOCS-3 e135:GCSFR:SOCS3 e136:SOCS-1:elongin C e137:degradants e138:Tel:Jak2 e14:gp130:gp130 e15:IL-6:IL-6Ralpha:gp130:gp130 e16:IL-11:IL-11Ralpha:gp130:gp130 e17:LIF:LIFR:gp130 e18:CT-1:LIFR:gp130 e19:CLC:CNTFR e2: e20:CLC:CNTFR:LIFR:gp130 e21:ErbB2:gp130 e22:IL-6:IL-6Ralpha:gp130{2}:Jak1 e23:IL-6:IL-6Ralpha:gp130{2}:Jak2 e24:IL-6:IL-6Ralpha:gp130{2}{p}:TYK2 e25:OSM:OSMR:gp130:Jak1 e26:OSM:OSMR:gp130:Jak2 e27:OSM:OSMR:gp130{p}:TYK2 e28:LIF:LIFR:gp130:Jak1 e29:LIF:LIFR:gp130:Jak2 e3: e30:LIF:LIFR:gp130{p}:TYK2 e31:IL-11:IL-11Ralpha:gp130:gp130:Hck e32:ERK{active} e33:Pyk2 e34:IL-6:IL-6Ralpha:gp130:gp130:Cdk9 e35:IL-6:IL-6Ralpha:gp130:gp130:PKCdelta e36:IFNalpha receptor 1 e37:IFNalpha receptor 1 e38:STAT3:caveolin-1 e39:STAT3:Hsp90 e4: e40:STAT3{active} e41:STAT1 e42:STAT5{active} e43:IL-6:IL-6Ralpha:gp130{2}:TYK2 e44:LIF:LIFR:gp130:TYK2 e45:OSM:OSMR:gp130:TYK2 e46:IL-6:IL-6Ralpha:gp130{2}{p}:TYK2:STAT1 e47:IL-6:IL-6Ralpha:gp130{2}{p}:TYK2:STAT3 e48:LIF:LIFR:gp130{p}:TYK2:STAT3 e49:IL-6:IL-6Ralpha:gp130{2}{p}:TYK2:STAT1{p} e5:IL-6:IL-6Ralpha e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IL-11:IL-11Ralpha e60: e61: e62: e63:IL-6:IL-6Ralpha:gp130{2}{p}:TYK2:STAT3{p} e64:LIF:LIFR:gp130{p}:TYK2:STAT3{p} e65:PRMT-1 e66:STAT1{met} e67:PRMT-1:IFNalpha receptor 1 e68:IFNbeta receptor 1 e69:PRMT-1:IFNbeta receptor 1 e7: e70:IFN e71:NPI-1 e72:Importin-alpha5 e73:Importin-alpha5{active} e74:NPI-1{active} e75:Ran e76:STAT1{active} e77:CRM-1{active} e78:CRM-1 e79:STAT1:Importin-alpha5 e8: e80:shc e81:OSM:OSMR:gp130:Jak1:shc{p} e82:OSM:OSMR:gp130:Jak1:shc e83:IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1 e84:SHP2 e85:IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SHP2 e86:IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SHP2{p} e87:Grb2:SOS e88:IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SHP2{p}:Grb2:SOS e89:Gab1 e9: e90:IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SHP2{p}:Gab1 e91:Grb2 e92:OSM:OSMR:gp130:Jak1:shc{p}:grb2 e93:OSM:OSMR:gp130:Jak1:shc{p}:grb2:SOS e94:ras{active} e95:ras e96:raf e97:raf{active} e98:STAT3:CBP e99:STAT1:CBP

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p114 p115 p116 p117 p118 p119 p12 p120 p121 p122 p123 p124 p125 p126 p127 p128 p129 p13 p130 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
715.0, 995.0
26.0, 26.0

EpoR

--

G010507

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p29

p30

true true true true

csml-variable:Double

m93473

10

false

infinite

0

unit false false false
TRANSFACG010507

--

Go back
604.0, 1184.0
24.0, 24.0

NMI

--

G011662

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p93 p94

true true true true

csml-variable:Double

m94491

10

false

infinite

0

unit false false false
TRANSFACG011662

--

Go back
830.0, 1110.0
20.0, 20.0

SOCS3

--

G011948

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p83 p84

true true true true

csml-variable:Double

m94757

10

false

infinite

0

unit false false false
TRANSFACG011948

--

Go back
670.0, 946.0
28.0, 28.0

OSMR

--

G012485

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p27

p28

true true true true

csml-variable:Double

m95214

10

false

infinite

0

unit false false false
TRANSFACG012485

--

Go back
440.0, 356.0
23.0, 23.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
371.0, 1463.0
18.0, 18.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p114 p115

true true true true

csml-variable:Double

m135

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
361.0, 1505.0
22.0, 22.0

Vav

--

MO000000044

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p100 p127

true true true true

csml-variable:Double

m117

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000044

--

Go back
562.0, 1162.0
20.0, 20.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p98

true true true true

csml-variable:Double

m113

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
1213.0, 1329.0
22.0, 22.0

EGF

--

MO000000071

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p109

true true true true

csml-variable:Double

m126

10

false

infinite

0

unit false false false
InterProIPR000033
TRANSPATHMO000000071

--

Go back
1119.0, 1139.0
26.0, 26.0

EpoR

--

MO000000092

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

p121

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
InterProIPR003528
TRANSPATHMO000000092

--

Go back
1214.0, 1402.0
20.0, 20.0

PDGF

--

MO000000098

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p110

true true true true

csml-variable:Double

m128

10

false

infinite

0

unit false false false
TRANSPATHMO000000098

--

Go back
263.0, 287.0
17.0, 17.0

Jak1

--

MO000000145

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p19 p27 p42

true true true true

csml-variable:Double

m129

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000145

--

Go back
411.0, 263.0
18.0, 18.0

Jak2

--

MO000000146

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p17 p20 p27 p29 p126

true true true true

csml-variable:Double

m130

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000146

--

Go back
217.0, 685.0
21.0, 21.0

Tyk2

--

MO000000148

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p18 p21 p27 p32

true true true true

csml-variable:Double

m132

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000148

--

Go back
739.0, 1475.0
18.0, 18.0

IRS-1

--

MO000000154

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p115 p128

true true true true

csml-variable:Double

m137

10

false

infinite

0

unit false false false
InterProIPR002404
TRANSPATHMO000000154

--

Go back
1193.0, 981.0
22.0, 22.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
616.0, 116.0
24.0, 24.0

CNTF

--

MO000003153

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m434

10

false

infinite

0

unit false false false
InterProIPR000151
TRANSPATHMO000003153

--

Go back
1205.0, 525.0
22.0, 22.0

CT-1

--

MO000003590

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m472

10

false

infinite

0

unit false false false
TRANSPATHMO000003590

--

Go back
234.0, 1466.0
20.0, 20.0

ERK2

--

MO000004676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p113

true true true true

csml-variable:Double

m554

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
369.0, 357.0
21.5, 21.5

Hck

--

MO000006538

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m751

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000006538

--

Go back
290.0, 126.0
19.0, 19.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
1117.0, 301.0
21.5, 21.5

LIF

--

MO000008548

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m1080

10

false

infinite

0

unit false false false
InterProIPR003624
TRANSPATHMO000008548

--

Go back
388.0, 816.0
24.0, 24.0

STAT1{active}

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36 p37 p39 p16 p43 p54 p58 p84

p68 p71 p86 p89

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
256.0, 1012.0
24.0, 24.0

STAT3

--

MO000013122

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p34 p35 p38 p40 p41 p44 p51 p52 p56 p59

true true true true

csml-variable:Double

m1360

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
1205.0, 1133.0
22.0, 22.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p84 p94

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
900.0, 532.0
16.0, 16.0

Sos

--

MO000016777

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p80

true true true true

csml-variable:Double

m1720

10

false

infinite

0

unit false false false
TRANSPATHMO000016777

--

Go back
442.0, 690.0
20.0, 20.0

Pyk2{p}

--

MO000016852

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m1785

10

false

infinite

0

unit false false false
TRANSPATHMO000016852

--

Go back
767.0, 367.0
18.0, 18.0

IRS-2

--

MO000016858

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p129

true true true true

csml-variable:Double

m1789

10

false

infinite

0

unit false false false
InterProIPR002404
TRANSPATHMO000016858

--

Go back
825.0, 113.0
21.0, 21.0

OSM

--

MO000016875

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p5

true true true true

csml-variable:Double

m1797

10

false

infinite

0

unit false false false
InterProIPR003623
TRANSPATHMO000016875

--

Go back
640.0, 504.0
20.0, 20.0

STAT5

--

MO000016876

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45 p49 p55 p57

true true true true

csml-variable:Double

m1798

10

false

infinite

0

unit false false false
TRANSPATHMO000016876

--

Go back
1199.0, 1055.0
18.0, 18.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p83

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
637.0, 361.0
22.0, 22.0

MAPK

--

MO000016894

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p106

true true true true

csml-variable:Double

m1812

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
666.0, 1490.0
20.0, 20.0

MKK4

--

MO000016917

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p102

true true true true

csml-variable:Double

m1832

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016917

--

Go back
133.0, 453.0
22.0, 22.0

gp130

--

MO000016943

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m1854

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000016943

--

Go back
1114.0, 1086.0
19.0, 19.0

OSMR

--

MO000016944

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

--

true true true true

csml-variable:Double

m1855

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000016944

--

Go back
642.0, 198.0
20.0, 20.0

CNTFRalpha

--

MO000016946

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m1857

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000016946

--

Go back
449.0, 121.0
22.0, 22.0

IL-11

--

MO000016949

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m1859

10

false

infinite

0

unit false false false
TRANSPATHMO000016949

--

Go back
515.0, 427.0
18.0, 18.0

SOCS-1

--

MO000017004

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p120 p125

true true true true

csml-variable:Double

m1906

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017004

--

Go back
958.0, 1478.0
20.0, 20.0

PIAS3

--

MO000017007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p119

true true true true

csml-variable:Double

m1908

10

false

infinite

0

unit false false false
InterProIPR004181
TRANSPATHMO000017007

--

Go back
1214.0, 1210.0
20.0, 20.0

IL-2

--

MO000017061

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p93 p107

true true true true

csml-variable:Double

m1954

10

false

infinite

0

unit false false false
TRANSPATHMO000017061

--

Go back
726.0, 466.0
20.0, 20.0

PKCdelta

--

MO000017065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p103

true true true true

csml-variable:Double

m1957

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017065

--

Go back
1219.0, 1279.0
18.0, 18.0

Epo

--

MO000017066

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p108

true true true true

csml-variable:Double

m1958

10

false

infinite

0

unit false false false
InterProIPR003013
TRANSPATHMO000017066

--

Go back
887.0, 1211.0
18.0, 18.0

SOCS-3

--

MO000017121

cso30:c:Protein

cso30:i:CC_CellComponent

--

p83 p107

p108 p109 p110 p121 p122 p123 p124

true true true true

csml-variable:Double

m2005

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017121

--

Go back
294.0, 1350.0
20.0, 20.0

Nmi

--

MO000017277

cso30:c:Protein

cso30:i:CC_CellComponent

--

p93 p94

p91 p92

true true true true

csml-variable:Double

m2131

10

false

infinite

0

unit false false false
TRANSPATHMO000017277

--

Go back
213.0, 1153.0
22.0, 22.0

caveolin-1

--

MO000017526

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m2322

10

false

infinite

0

unit false false false
InterProIPR001612
TRANSPATHMO000017526

--

Go back
926.0, 1502.0
18.0, 18.0

PIAS1

--

MO000017700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p116 p117

true true true true

csml-variable:Double

m2460

10

false

infinite

0

unit false false false
InterProIPR004181
TRANSPATHMO000017700

--

Go back
657.0, 273.0
21.0, 21.0

Cdk9

--

MO000017758

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m2515

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017758

--

Go back
130.0, 414.0
27.0, 27.0

ErbB2

--

MO000018279

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m2935

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000018279

--

Go back
201.0, 197.0
22.0, 22.0

IL-6Ralpha

--

MO000018458

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3096

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000018458

--

Go back
426.0, 530.0
20.0, 20.0

elongin C

--

MO000018946

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p125

true true true true

csml-variable:Double

m3558

10

false

infinite

0

unit false false false
InterProIPR001232
TRANSPATHMO000018946

--

Go back
811.0, 199.0
25.0, 25.0

OSMR:gp130

--

MO000018966

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m3577

10

false

infinite

0

unit false false false
TRANSPATHMO000018966

--

Go back
1031.0, 195.0
26.0, 26.0

LIFR:gp130

--

MO000018967

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p8 p9 p10 p11

true true true true

csml-variable:Double

m3578

10

false

infinite

0

unit false false false
TRANSPATHMO000018967

--

Go back
1117.0, 409.0
22.0, 22.0

CNTF:CNTFRalpha:LIFR:gp130

--

MO000018968

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p39 p40

true true true true

csml-variable:Double

m3579

10

false

infinite

0

unit false false false
TRANSPATHMO000018968

--

Go back
462.0, 1386.0
20.0, 20.0

p300

--

MO000019984

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p88 p89 p90

true true true true

csml-variable:Double

m4512

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000019984

--

Go back
312.0, 1076.0
24.0, 24.0

Hsp90

--

MO000021135

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m5516

10

false

infinite

0

unit false false false
TRANSPATHMO000021135

--

Go back
823.0, 319.0
18.0, 18.0

SMRT

--

MO000031185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p95

true true true true

csml-variable:Double

m10730

10

false

infinite

0

unit false false false
InterProIPR001005
TRANSPATHMO000031185

--

Go back
374.0, 210.0
20.5, 20.5

IL-11Ralpha

--

MO000058820

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m33847

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000058820

--

Go back
901.0, 1677.0
22.0, 22.0

LEPR

--

MO000066172

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p123

true true true true

csml-variable:Double

m41032

10

false

infinite

0

unit false false false
TRANSPATHMO000066172

--

Go back
662.0, 1678.0
20.0, 20.0

GCSFR

--

MO000089770

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p124

true true true true

csml-variable:Double

m63352

10

false

infinite

0

unit false false false
TRANSPATHMO000089770

--

Go back
520.0, 1336.0
24.0, 24.0

CBP

--

MO000099682

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85 p86 p87

true true true true

csml-variable:Double

m72733

10

false

infinite

0

unit false false false
TRANSPATHMO000099682

--

Go back
109.1967572280872, 185.18863469081958
1059.7283798457493, 1538.7256075360285

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
118.72699855156122, 258.998881591034
985.7965535332085, 1386.7385600412704

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
622.5, 1388.0
19.090484919180135, 23.376103982669562

STAT5:CBP

--

e100

cso30:c:Complex

cso30:i:CC_Cytosol

--

p87

p92

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
586.5, 1452.0
19.090484919180135, 23.376103982669562

STAT3:p300

--

e101

cso30:c:Complex

cso30:i:CC_Cytosol

--

p88

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
734.5, 1424.0
19.090484919180135, 23.376103982669562

STAT1:p300

--

e102

cso30:c:Complex

cso30:i:CC_Cytosol

--

p89

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
742.5, 1372.0
19.090484919180135, 23.376103982669562

STAT5:p300

--

e103

cso30:c:Complex

cso30:i:CC_Cytosol

--

p90

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
394.5, 1342.0
19.507432556432374, 27.219673334556806

STAT1:CBP:Nmi

--

e104

cso30:c:Complex

cso30:i:CC_Cytosol

--

p91

--

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
434.5, 1430.0
19.58634611855387, 27.329785281703067

STAT5:CBP:Nmi

--

e105

cso30:c:Complex

cso30:i:CC_Cytosol

--

p92

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
761.5, 303.0
21.7033827695384, 26.575570738210295

SMRT:STAT5

--

e106

cso30:c:Complex

cso30:i:CC_Cytosol

--

p95

--

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
696.0, 1156.0
24.0, 24.0

STAT3

--

e107

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p96 p99 p105 p119

true true true true

csml-variable:Double

m109

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
693.0, 1108.5
21.12, 15.84

FKHR

--

e108

cso30:c:Protein

cso30:i:CC_Nucleolus

--

--

p96 p98

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
766.0, 1053.0
19.740331491712716, 21.933701657458567

STAT3:FKHR

--

e109

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p96

p97

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
709.5, 180.0
20.730103047577284, 40.12278009208507

CNTF:CNTFRalpha

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p9

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
834.0, 1024.0
42.45674740484429, 22.643598615916954

mRNA

--

e110

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p97 p118 p119

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
673.0, 1212.5
21.12, 15.84

FKHR{p}

--

e111

cso30:c:Protein

cso30:i:CC_Nucleolus

--

p98

--

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
817.0, 1171.0
14.994387277829746, 34.60243217960709

EZI

--

e112

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p99

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
598.0, 1061.0
19.64088397790055, 21.823204419889503

STAT3:EZI

--

e113

cso30:c:Complex

cso30:i:CC_Cytosol

--

p99

--

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
461.0, 1553.0
22.0, 22.0

Vav{active}

--

e114

cso30:c:Protein

cso30:i:CC_CellComponent

--

p100

p101

true true true true

csml-variable:Double

m118

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000044

--

Go back
477.0, 1496.0
13.693171188026188, 31.59962581852198

Rac-1

--

e115

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p101

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
605.0, 1576.0
13.693171188026188, 31.59962581852198

Rac-1{active}

--

e116

cso30:c:Protein

cso30:i:CC_Cytosol

--

p101

p102

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
746.0, 1546.0
20.0, 20.0

MKK4{active}

--

e117

cso30:c:Protein

cso30:i:CC_CellComponent

--

p102

p103

true true true true

csml-variable:Double

m121

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016917

--

Go back
842.0, 1394.0
20.0, 20.0

PKCdelta{active}

--

e118

cso30:c:Protein

cso30:i:CC_CellComponent

--

p103

p104

true true true true

csml-variable:Double

m122

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017065

--

Go back
770.0, 1198.0
20.0, 20.0

PKCdelta{active}

--

e119

cso30:c:Protein

cso30:i:CC_CellComponent

--

p104

p105

true true true true

csml-variable:Double

m123

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017065

--

Go back
881.5, 185.0
21.60653330886402, 30.148651128647476

OSM:OSMR:gp130

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p17 p18 p42 p115

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
864.0, 1088.0
24.0, 24.0

STAT3{p}

--

e120

cso30:c:Protein

cso30:i:CC_CellComponent

--

p105

--

true true true true

csml-variable:Double

m124

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
725.0, 377.0
22.0, 22.0

MAPK{active}

--

e121

cso30:c:Protein

cso30:i:CC_CellComponent

--

p106

--

true true true true

csml-variable:Double

m125

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
959.5, 689.0
17.89018496917181, 21.906348941843024

SOCS3:Ras

--

e122

cso30:c:Complex

cso30:i:CC_Extracellular

--

p111

--

true true true true

csml-variable:Double

m131

0

false

infinite

0

unit false false false

--

Go back
819.0, 1335.0
18.0, 18.0

SOCS-3{p}

--

e123

cso30:c:Protein

cso30:i:CC_CellComponent

--

p107 p108 p109 p110

p111

true true true true

csml-variable:Double

m127

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017121

--

Go back
141.0, 1586.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SHP2{p}:Gab1{p}

--

e124

cso30:c:Complex

cso30:i:CC_Cytosol

--

p112

p113 p114

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false false false

--

Go back
306.0, 1442.0
20.0, 20.0

ERK2{active}

--

e125

cso30:c:Protein

cso30:i:CC_CellComponent

--

p113

--

true true true true

csml-variable:Double

m134

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
261.0, 1670.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SHP2{p}:Gab1{p}:PI3K

--

e126

cso30:c:Complex

cso30:i:CC_Cytosol

--

p114

--

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false false false

--

Go back
832.5, 1506.0
15.677387102149643, 19.196800533244463

PI3K:IRS-1

--

e127

cso30:c:Complex

cso30:i:CC_Cytosol

--

p115

--

true true true true

csml-variable:Double

m138

0

false

infinite

0

unit false false false

--

Go back
970.5, 1437.0
18.68221963006165, 22.87618730211631

STAT1:PIAS1

--

e128

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p116

--

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
589.0, 962.5
53.52082780578403, 11.59617935791987

DNA

--

e129

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p117

true true true true

csml-variable:Double

m140

0

false

infinite

0

unit false false false

--

Go back
1080.5, 175.0
23.95026610387228, 33.418975958891565

OSM:LIFR:gp130

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
570.0, 991.5
53.27333504757007, 15.094111596811521

STAT1:DNA

--

e130

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p117

p118

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false false false

--

Go back
137.0, 226.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SOCS1

--

e131

cso30:c:Complex

cso30:i:CC_Cytosol

--

p120

--

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false false false

--

Go back
1122.5, 1473.0
19.486296864722647, 37.71541328655996

EpoR:SOCS-3

--

e132

cso30:c:Complex

cso30:i:CC_Cytosol

--

p121

--

true true true true

csml-variable:Double

m143

0

false

infinite

0

unit false false false

--

Go back
1117.0, 1542.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SOCS3

--

e133

cso30:c:Complex

cso30:i:CC_Cytosol

--

p122

--

true true true true

csml-variable:Double

m144

0

false

infinite

0

unit false false false

--

Go back
790.5, 1675.0
18.07936855952642, 34.99232624424468

LEPR:SOCS-3

--

e134

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p123

--

true true true true

csml-variable:Double

m145

0

false

infinite

0

unit false false false

--

Go back
998.5, 1677.0
19.669809252356938, 38.07059855294892

GCSFR:SOCS3

--

e135

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p124

--

true true true true

csml-variable:Double

m146

0

false

infinite

0

unit false false false

--

Go back
449.5, 575.0
21.001166472254624, 25.715714047658725

SOCS-1:elongin C

--

e136

cso30:c:Complex

cso30:i:CC_Cytosol

--

p125

p126 p127 p128 p129 p130

true true true true

csml-variable:Double

m147

0

false

infinite

0

unit false false false

--

Go back
882.0, 390.0
19.91958644457209, 19.255600229753014

degradants

--

e137

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p126 p127 p128 p129 p130

--

true true true true

csml-variable:Double

m148

0

false

infinite

0

unit false false false

--

Go back
888.5, 318.0
20.552074654224292, 25.165805699050146

Tel:Jak2

--

e138

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p130

true true true true

csml-variable:Double

m149

0

false

infinite

0

unit false false false

--

Go back
131.0, 267.0
26.0, 26.0

gp130:gp130

--

e14

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p7

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
TRANSPATHMO000018967

--

Go back
137.0, 309.0
22.676470588235293, 37.794117647058826

IL-6:IL-6Ralpha:gp130:gp130

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p13 p14 p15 p22 p23 p24 p25 p26

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
133.0, 361.0
22.676470588235293, 37.794117647058826

IL-11:IL-11Ralpha:gp130:gp130

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p37 p38

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1111.5, 223.0
24.83409799963297, 34.652229766929715

LIF:LIFR:gp130

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p19 p20 p21

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1115.5, 623.0
24.518443751147007, 34.211781978344675

CT-1:LIFR:gp130

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p54 p55 p56

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1118.5, 682.0
18.174523130892347, 35.176496382372285

CLC:CNTFR

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
109.1967572280872, 185.18863469081958
1059.7283798457493, 1538.7256075360285

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1116.0, 744.0
23.64705882352942, 39.41176470588236

CLC:CNTFR:LIFR:gp130

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p57 p58 p59

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
132.5, 490.0
23.24662556240626, 28.46525579070155

ErbB2:gp130

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
133.0, 586.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}:Jak1

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p73

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
129.0, 878.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}:Jak2

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
133.0, 982.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}{p}:TYK2

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p35 p36 p50 p51

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
492.0, 181.0
23.38235294117647, 38.970588235294116

OSM:OSMR:gp130:Jak1

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p72

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1116.0, 801.0
23.38235294117647, 38.970588235294116

OSM:OSMR:gp130:Jak2

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1112.0, 945.0
23.38235294117647, 38.970588235294116

OSM:OSMR:gp130{p}:TYK2

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

p16 p41 p45

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
129.0, 1030.0
21.882352941176475, 36.47058823529412

LIF:LIFR:gp130:Jak1

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1121.0, 1010.0
21.882352941176475, 36.47058823529412

LIF:LIFR:gp130:Jak2

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
130.39132482500221, 214.62239712037922
1017.3392446519198, 1496.3364723422003

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
129.0, 1098.0
21.882352941176475, 36.47058823529412

LIF:LIFR:gp130{p}:TYK2

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

p43 p44 p49 p52

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
133.0, 533.0
22.676470588235293, 37.794117647058826

IL-11:IL-11Ralpha:gp130:gp130:Hck

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
560.0, 460.0
23.0, 23.0

ERK{active}

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

--

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
606.0, 766.0
20.0, 20.0

Pyk2

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24

--

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000016852

--

Go back
130.0, 183.0
20.470588235294116, 34.11764705882353

IL-6:IL-6Ralpha:gp130:gp130:Cdk9

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
549.0, 165.0
22.676470588235293, 37.794117647058826

IL-6:IL-6Ralpha:gp130:gp130:PKCdelta

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
681.0, 1056.0
45.83044982698962, 24.442906574394463

IFNalpha receptor 1

--

e36

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p32

p31

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1119.5, 1208.0
25.771528998242527, 39.64850615114235

IFNalpha receptor 1

--

e37

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p31

p63

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
183.5, 1037.0
19.351774704215966, 23.69605065822363

STAT3:caveolin-1

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
248.5, 1186.0
22.503582736210635, 27.555407432094654

STAT3:Hsp90

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
169.60127487929503, 243.47369558233578
938.9193445433341, 1422.1554857529948

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
368.0, 896.0
24.0, 24.0

STAT3{active}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35 p38 p40 p41 p44 p56 p59 p70

p85 p88

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
256.0, 760.0
24.0, 24.0

STAT1

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p37 p39 p16 p43 p50 p54 p58 p62 p84 p116

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
814.0, 546.0
20.0, 20.0

STAT5{active}

--

e42

cso30:c:Protein

cso30:i:CC_CellComponent

--

p45 p49 p55 p57

p87 p90 p95

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
TRANSPATHMO000016876

--

Go back
133.0, 930.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}:TYK2

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p46

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
129.0, 1154.0
21.882352941176475, 36.47058823529412

LIF:LIFR:gp130:TYK2

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p47

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1108.0, 873.0
23.38235294117647, 38.970588235294116

OSM:OSMR:gp130:TYK2

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p48

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
129.0, 1214.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}{p}:TYK2:STAT1

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p53

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
129.0, 1274.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}{p}:TYK2:STAT3

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p60

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
133.0, 1326.0
21.882352941176475, 36.47058823529412

LIF:LIFR:gp130{p}:TYK2:STAT3

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

p61

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
129.0, 1390.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}{p}:TYK2:STAT1{p}

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p53

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
295.5, 192.0
17.046261784696338, 32.99276474457357

IL-6:IL-6Ralpha

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p6 p97 p105 p119

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
486.23671073687757, 882.610753331004
418.56959738046663, 379.59663673051733

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
531.44534509082, 891.6066417748085
244.75019288168826, 367.90474853553224

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
491.6929252278708, 887.6772382154977
407.65716839848085, 369.46366696153

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
492.4723844408696, 888.4566974284962
406.09824997248234, 367.90474853553224

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
486.23671073687757, 882.610753331004
418.56959738046663, 379.59663673051733

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
486.23671073687757, 882.610753331004
418.56959738046663, 379.59663673051733

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
492.4723844408696, 888.4566974284962
406.09824997248234, 367.90474853553224

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
791.7847222324881, 1038.5025959308057
26.149928611973554, 23.672566953997183

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
723.1923114885756, 1147.6268857506666
74.0486252349056, 67.03349231791483

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
486.23671073687757, 882.610753331004
418.56959738046663, 379.59663673051733

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
421.5, 191.0
21.803990352992766, 42.20127165095374

IL-11:IL-11Ralpha

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p7

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
584.8912097104359, 1051.3003620612153
13.255484125620459, 6.382270134558023

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
584.448571574752, 1032.2669222268146
45.37040890758366, 81.66673603365082

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
603.4820114091538, 1085.383498508863
7.0822101709398835, 7.0822101709399075

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
137.0, 1450.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}{p}:TYK2:STAT3{p}

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p60

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
137.0, 1514.0
21.882352941176475, 36.47058823529412

LIF:LIFR:gp130{p}:TYK2:STAT3{p}

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p61

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
438.0, 1128.5
19.840000000000007, 14.879999999999997

PRMT-1

--

e65

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p62 p63 p64

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
420.0, 1024.0
24.0, 24.0

STAT1{met}

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

p62

--

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
1117.5, 1280.0
20.961192720894537, 40.57005042753783

PRMT-1:IFNalpha receptor 1

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1119.5, 1340.0
25.771528998242527, 39.64850615114235

IFNbeta receptor 1

--

e68

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p64

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1121.5, 1404.0
20.961192720894537, 40.57005042753783

PRMT-1:IFNbeta receptor 1

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
117.48889227346035, 182.65518423716196
917.5108940026548, 1300.0892372583753

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1210.0, 814.0
12.136576239476145, 28.007483629560337

IFN

--

e70

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p65 p68

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
892.5, 855.0
15.64439525055343, 25.36928959549205

NPI-1

--

e71

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p67

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
557.0, 791.5
22.720000000000002, 17.040000000000003

Importin-alpha5

--

e72

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p66

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
713.0, 763.5
22.720000000000002, 17.040000000000003

Importin-alpha5{active}

--

e73

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p66

p71

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
848.5, 851.0
15.64439525055343, 25.36928959549205

NPI-1{active}

--

e74

cso30:c:Protein

cso30:i:CC_Cytosol

--

p67

p68

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
944.0, 884.5
24.36707587039645, 15.026363453411145

Ran

--

e75

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p66 p67 p69

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
724.0, 916.0
24.0, 24.0

STAT1{active}

--

e76

cso30:c:Protein

cso30:i:CC_CellComponent

--

p65 p68

p70 p117

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
545.0, 1071.5
22.560000000000006, 16.920000000000005

CRM-1{active}

--

e77

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p69

p70

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
529.0, 1111.5
22.560000000000006, 16.920000000000005

CRM-1

--

e78

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p69

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
494.5, 853.0
18.175970671554737, 22.256290618230295

STAT1:Importin-alpha5

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p71

p65

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
120.76679495222646, 205.60050298852522
880.1791334658719, 1278.0201017924476

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
545.0, 343.5
22.08, 16.560000000000002

shc

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p72

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
1112.0, 445.0
23.38235294117647, 38.970588235294116

OSM:OSMR:gp130:Jak1:shc{p}

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p78

p79

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
932.0, 169.0
23.38235294117647, 38.970588235294116

OSM:OSMR:gp130:Jak1:shc

--

e82

cso30:c:Complex

cso30:i:CC_Cytosol

--

p72

p78

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
133.0, 634.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p73

p74 p120 p122

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
307.0, 612.5
25.828134433487623, 15.927349567317371

SHP2

--

e84

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p74

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
133.0, 686.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SHP2

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p74

p75

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
133.0, 734.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SHP2{p}

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p75

p76 p77

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
346.5, 668.0
19.261956340609895, 23.586068988501914

Grb2:SOS

--

e87

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p76

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
133.0, 782.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SHP2{p}:Grb2:SOS

--

e88

cso30:c:Complex

cso30:i:CC_Cytosol

--

p74 p76

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
320.5, 524.0
14.28919299657879, 23.17166431877641

Gab1

--

e89

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p77

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
129.50786876226977, 228.54582173988857
876.1606329130734, 1261.2591884003016

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
137.0, 826.0
21.0, 35.00000000000002

IL-6:IL-6Ralpha:gp130{2}{p}}:Jak1:SHP2{p}:Gab1

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

p77

p112

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
775.0, 452.5
25.562487422016503, 15.763533910243515

Grb2

--

e91

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p79

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1116.0, 505.0
23.38235294117647, 38.970588235294116

OSM:OSMR:gp130:Jak1:shc{p}:grb2

--

e92

cso30:c:Complex

cso30:i:CC_Cytosol

--

p79

p80

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
1116.0, 565.0
23.38235294117647, 38.970588235294116

OSM:OSMR:gp130:Jak1:shc{p}:grb2:SOS

--

e93

cso30:c:Complex

cso30:i:CC_Cytosol

--

p80

p81

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
779.0, 644.0
10.78671655753039, 24.892422825070145

ras{active}

--

e94

cso30:c:Protein

cso30:i:CC_Cytosol

--

p81

p82

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
747.0, 594.0
10.78671655753039, 24.892422825070145

ras

--

e95

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p81 p111

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
608.0, 535.5
23.039999999999996, 17.28

raf

--

e96

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p82

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
670.0, 476.5
20.159999999999997, 15.120000000000001

raf{active}

--

e97

cso30:c:Protein

cso30:i:CC_Cytosol

--

p82

p106

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
414.5, 1312.0
19.090484919180135, 23.376103982669562

STAT3:CBP

--

e98

cso30:c:Complex

cso30:i:CC_Cytosol

--

p85

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
334.5, 1260.0
19.090484919180135, 23.376103982669562

STAT1:CBP

--

e99

cso30:c:Complex

cso30:i:CC_Cytosol

--

p86

p91

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
197.0, 125.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007384 MO000018458

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m871*m3096*0.1

nodelay

--

true

0

false

PMID: 12773095 IL-6, IL-11 and CNTF first bind specifically to their respective ¦Á-receptor subunits.

Go back
1205.0, 449.0
21.0, 21.0

p8

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000003590 MO000018967

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m472*m3578*0.1

nodelay

--

true

0

false

PMID: 12773095 The remaining IL-6 type cytokines signal via heterodimers of either gp130 and the LIFR (LIF, CNTF, CT-1 and CLC) or gp130 and the OSMR (OSM).

Go back
394.0, 1554.0
19.0, 19.0

p100

p100

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000044

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c290 : 1
stoichiometry:c291 : 1

m117*0.1

nodelay

--

true

0

false

PMID: 12773095 A sequential activation of Vav, Rac-1, MKK-4 (MAP kinase kinase 4) and PKC¦Ä is necessary for the IL-6- mediated STAT3 Ser727 phosphorylation and transactivation in HepG2 cells.

Go back
530.0, 1582.0
19.0, 19.0

p100

p101

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e115 e114

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c293 : 1
stoichiometry:c292 : 1
stoichiometry:c294 : 1

m119*m118*0.1

nodelay

--

true

0

false

PMID: 12773095 A sequential activation of Vav, Rac-1, MKK-4 (MAP kinase kinase 4) and PKC¦Ä is necessary for the IL-6- mediated STAT3 Ser727 phosphorylation and transactivation in HepG2 cells.

Go back
670.0, 1550.0
19.0, 19.0

p100

p102

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e116 MO000016917

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c295 : 1
stoichiometry:c296 : 1
stoichiometry:c297 : 1

m120*m1832*0.1

nodelay

--

true

0

false

PMID: 12773095 A sequential activation of Vav, Rac-1, MKK-4 (MAP kinase kinase 4) and PKC¦Ä is necessary for the IL-6- mediated STAT3 Ser727 phosphorylation and transactivation in HepG2 cells.

Go back
786.0, 1474.0
19.0, 19.0

p100

p103

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e117 MO000017065

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c298 : 1
stoichiometry:c299 : 1
stoichiometry:c300 : 1

m121*m1957*0.1

nodelay

--

true

0

false

PMID: 12773095 A sequential activation of Vav, Rac-1, MKK-4 (MAP kinase kinase 4) and PKC¦Ä is necessary for the IL-6- mediated STAT3 Ser727 phosphorylation and transactivation in HepG2 cells.

Go back
742.0, 1294.0
19.0, 19.0

p104

p104

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e118

e119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c301 : 1
stoichiometry:c302 : 1

m122*0.1

nodelay

--

true

0

false

PMID: 12773095 A sequential activation of Vav, Rac-1, MKK-4 (MAP kinase kinase 4) and PKC¦Ä is necessary for the IL-6- mediated STAT3 Ser727 phosphorylation and transactivation in HepG2 cells. PMID: 12773095,11335711 Moreover, there is evidence that the PKC¦Ä-mediated STAT3 Ser727 phosphorylation occurs in the nucleus

Go back
790.0, 1110.0
19.0, 19.0

p105

p105

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e119 e107 e5

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c303 : 1
stoichiometry:c304 : 1
stoichiometry:c306 : 1
stoichiometry:c305 : 1

m123*m109*m5*0.1

nodelay

--

true

0

false

PMID: 12773095 A sequential activation of Vav, Rac-1, MKK-4 (MAP kinase kinase 4) and PKC¦Ä is necessary for the IL-6- mediated STAT3 Ser727 phosphorylation and transactivation in HepG2 cells. PMID: 12773095,11335711 Moreover, there is evidence that the PKC¦Ä-mediated STAT3 Ser727 phosphorylation occurs in the nucleus

Go back
674.0, 398.0
19.0, 19.0

p82

p106

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e97 MO000016894

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c307 : 1
stoichiometry:c308 : 1
stoichiometry:c309 : 1

m99*m1812*0.1

nodelay

--

true

0

false

PMID: 12773095 Finally, recruitment of SOS to the receptor complex at the membrane allows Ras activation, which in turn leads to the activation of the Ras?Raf?MAPK cascade

Go back
858.0, 1250.0
19.0, 19.0

p107

p107

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017061

MO000017121 e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c312 : 1
stoichiometry:c310 : 1
stoichiometry:c311 : 1

m1954*0.1

nodelay

--

true

0

false

PMID: 12773095 In response to IL-2, Epo, EGF, and PDGF, SOCS3 (suppressor of cytokine signalling 3) becomes tyrosine phosphorylated, and subsequently binds and inactivates Ras/GTPase-activating protein.

Go back
906.0, 1298.0
19.0, 19.0

p107

p108

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017066 MO000017121

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c313 : 1
stoichiometry:c314 : 1
stoichiometry:c315 : 1

m1958*m2005*0.1

nodelay

--

true

0

false

PMID: 12773095 In response to IL-2, Epo, EGF, and PDGF, SOCS3 (suppressor of cytokine signalling 3) becomes tyrosine phosphorylated, and subsequently binds and inactivates Ras/GTPase-activating protein.

Go back
886.0, 1334.0
19.0, 19.0

p107

p109

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000071 MO000017121

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c316 : 1
stoichiometry:c317 : 1
stoichiometry:c318 : 1

m126*m2005*0.1

nodelay

--

true

0

false

PMID: 12773095 In response to IL-2, Epo, EGF, and PDGF, SOCS3 (suppressor of cytokine signalling 3) becomes tyrosine phosphorylated, and subsequently binds and inactivates Ras/GTPase-activating protein.

Go back
949.0, 633.0
21.0, 21.0

p8

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018967 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m3578*m19*0.1

nodelay

--

true

0

false

PMID: 12773095 The remaining IL-6 type cytokines signal via heterodimers of either gp130 and the LIFR (LIF, CNTF, CT-1 and CLC) or gp130 and the OSMR (OSM).

Go back
978.0, 1394.0
19.0, 19.0

p107

p110

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000098 MO000017121

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c319 : 1
stoichiometry:c320 : 1
stoichiometry:c321 : 1

m128*m2005*0.1

nodelay

--

true

0

false

PMID: 12773095 In response to IL-2, Epo, EGF, and PDGF, SOCS3 (suppressor of cytokine signalling 3) becomes tyrosine phosphorylated, and subsequently binds and inactivates Ras/GTPase-activating protein.

Go back
879.0, 639.0
19.0, 19.0

p111

p111

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e95 e123

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c322 : 1
stoichiometry:c323 : 1
stoichiometry:c324 : 1

m97*m127*0.1

nodelay

--

true

0

false

PMID: 12773095 In response to IL-2, Epo, EGF, and PDGF, SOCS3 (suppressor of cytokine signalling 3) becomes tyrosine phosphorylated, and subsequently binds and inactivates Ras/GTPase-activating protein.

Go back
303.0, 1223.0
17.0, 17.0

p112

p112

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e90

e124

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c325 : 1
stoichiometry:c326 : 1

m92*0.1

nodelay

--

true

0

false

PMID: 12773095 In response to IL-6, Gab1 is tyrosine phosphorylated and interacts subsequently with SHP2 and PI3K.

Go back
214.0, 1522.0
19.0, 19.0

p113

p113

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e124 MO000004676

e125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c327 : 1
stoichiometry:c328 : 1
stoichiometry:c329 : 1

m133*m554*0.1

nodelay

--

true

0

false

PMID: 12773095,9632795 Finally, IL-6-induced association of Gab1 with SHP2 leads to activation of ERK2

Go back
311.0, 1487.0
17.0, 17.0

p114

p114

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000030 e124

e126

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c330 : 1
stoichiometry:c331 : 1
stoichiometry:c332 : 1

m135*m133*0.1

nodelay

--

true

0

false

PMID: 12773095,9632795 After IL-6 stimulation the adaptor protein Gab1 interacts with PI3K

Go back
590.0, 1490.0
19.0, 19.0

p115

p115

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000030 MO000000154 e12

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c333 : 1
stoichiometry:c334 : 1
stoichiometry:c336 : 1
stoichiometry:c335 : 1

m135*m137*m12*0.1

nodelay

--

true

0

false

--

Go back
890.0, 1438.0
19.0, 19.0

p116

p116

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e41 MO000017700

e128

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c337 : 1
stoichiometry:c338 : 1
stoichiometry:c339 : 1

m42*m2460*0.1

nodelay

--

true

0

false

PMID: 12773095,11257227 As mentioned above, PIAS1 preferentially associates with unmethylated STAT1

Go back
791.0, 931.0
17.0, 17.0

p117

p117

cso30:i:ME_DNABinding

cso30:i:CC_Cytosol

--

e76 e129 MO000017700

e130

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c340 : 1
stoichiometry:c341 : 1
stoichiometry:c343 : 1
stoichiometry:c342 : 1

m77*m140*0.1

nodelay

--

true

0

false

PMID: 12773095,9724754 Whereas PIAS1 specifically inhibits DNA binding of activated STAT1 and thus STAT1-mediated gene induction (after IFN stimulation)

Go back
735.0, 979.0
17.0, 17.0

p118

p118

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearEnvelopeLumen

--

e130

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c344 : 1
stoichiometry:c345 : 1

m141*0.1

nodelay

--

true

0

false

PMID: 12773095,9724754 Whereas PIAS1 specifically inhibits DNA binding of activated STAT1 and thus STAT1-mediated gene induction (after IFN stimulation)

Go back
786.0, 1062.0
19.0, 19.0

p119

p119

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e107 MO000017007 e5

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c346 : 1
stoichiometry:c348 : 1
stoichiometry:c352 : 1
stoichiometry:c347 : 1

m109*m5*0.1

nodelay

--

true

0

false

PMID: 12773095,9388184 PIAS3 was found to be specific for the inhibition of STAT3-mediated gene expression (after IL-6 stimulation)

Go back
198.0, 458.0
19.0, 19.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018279 MO000016943

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m2935*m1854*0.1

nodelay

--

true

0

false

PMID: 12773095,9590694 Moreover, itwas reported that ErbB2 forms a complexwith gp130 in an IL-6-dependent manner in prostate carcinoma cells

Go back
407.0, 483.0
17.0, 17.0

p120

p120

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017004 e83

e131

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c349 : 1
stoichiometry:c350 : 1
stoichiometry:c351 : 1

m1906*m85*0.1

nodelay

--

true

0

false

PMID: 12773095 SOCS1 inhibits signal transduction by binding to the activation loop of the JAKs via its SH2 domain.

Go back
938.0, 1170.0
19.0, 19.0

p121

p121

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000092 MO000017121

e132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c353 : 1
stoichiometry:c354 : 1
stoichiometry:c355 : 1

m82*m2005*0.1

nodelay

--

true

0

false

PMID: 12773095,10777583,10829066,10882725,11108838,11018044,12133942,12027890 SOCS3 associates with specific phosphotyrosine motifs within activated cytokine receptors, such as gp130, EpoR, leptin receptor and the granulocyte colony-stimulating factor receptor

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1002.0, 1494.0
19.0, 19.0

p121

p122

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e83 MO000017121

e133

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c356 : 1
stoichiometry:c357 : 1
stoichiometry:c358 : 1

m85*m2005*0.1

nodelay

--

true

0

false

PMID: 12773095,10777583,10829066,10882725,11108838,11018044,12133942,12027890 SOCS3 associates with specific phosphotyrosine motifs within activated cytokine receptors, such as gp130, EpoR, leptin receptor and the granulocyte colony-stimulating factor receptor

Go back
854.0, 1550.0
19.0, 19.0

p121

p123

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066172 MO000017121

e134

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c359 : 1
stoichiometry:c360 : 1
stoichiometry:c361 : 1

m41032*m2005*0.1

nodelay

--

true

0

false

PMID: 12773095,10777583,10829066,10882725,11108838,11018044,12133942,12027890 SOCS3 associates with specific phosphotyrosine motifs within activated cytokine receptors, such as gp130, EpoR, leptin receptor and the granulocyte colony-stimulating factor receptor

Go back
782.0, 1562.0
19.0, 19.0

p121

p124

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017121 MO000089770

e135

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c362 : 1
stoichiometry:c363 : 1
stoichiometry:c364 : 1

m2005*m63352*0.1

nodelay

--

true

0

false

PMID: 12773095,10777583,10829066,10882725,11108838,11018044,12133942,12027890 SOCS3 associates with specific phosphotyrosine motifs within activated cytokine receptors, such as gp130, EpoR, leptin receptor and the granulocyte colony-stimulating factor receptor

Go back
486.0, 470.0
19.0, 19.0

p125

p125

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017004 MO000018946

e136

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c365 : 1
stoichiometry:c366 : 1
stoichiometry:c367 : 1

m1906*m3558*0.1

nodelay

--

true

0

false

PMID: 12773095 In this complex, the SOCS proteins interact with elongin C via the SOCS box.

Go back
378.0, 430.0
19.0, 19.0

p126

p126

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e136 MO000000146

e137

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c368 : 1
stoichiometry:c369 : 1
stoichiometry:c370 : 1

m147*m130*0.1

nodelay

--

true

0

false

PMID: 12773095,11313480,11278610,11971965,12228220,10747851 Consistent with the postulated E3-ligase function are new findings that SOCS1 targets JAK2, Tel-JAK2 and IRS1/2, as well as Vav, to degradation

Go back
478.0, 638.0
19.0, 19.0

p126

p127

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e136 MO000000044

e137

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c371 : 1
stoichiometry:c372 : 1
stoichiometry:c373 : 1

m147*m117*0.1

nodelay

--

true

0

false

PMID: 12773095,11313480,11278610,11971965,12228220,10747851 Consistent with the postulated E3-ligase function are new findings that SOCS1 targets JAK2, Tel-JAK2 and IRS1/2, as well as Vav, to degradation

Go back
562.0, 566.0
19.0, 19.0

p126

p128

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e136 MO000000154

e137

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c374 : 1
stoichiometry:c375 : 1
stoichiometry:c376 : 1

m147*m137*0.1

nodelay

--

true

0

false

PMID: 12773095,11313480,11278610,11971965,12228220,10747851 Consistent with the postulated E3-ligase function are new findings that SOCS1 targets JAK2, Tel-JAK2 and IRS1/2, as well as Vav, to degradation

Go back
566.0, 394.0
19.0, 19.0

p126

p129

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e136 MO000016858

e137

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c377 : 1
stoichiometry:c378 : 1
stoichiometry:c379 : 1

m147*m1789*0.1

nodelay

--

true

0

false

PMID: 12773095,11313480,11278610,11971965,12228220,10747851 Consistent with the postulated E3-ligase function are new findings that SOCS1 targets JAK2, Tel-JAK2 and IRS1/2, as well as Vav, to degradation

Go back
278.0, 562.0
19.0, 19.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000145 e15

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c64 : 1
stoichiometry:c39 : 1

m129*m15*0.1

nodelay

--

true

0

false

PMID: 12773095,8272872,11786531,10586060 The signal transducing chains gp130, LIFR and OSMR bind to JAK1, JAK2and TYK2

Go back
782.0, 410.0
19.0, 19.0

p126

p130

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e136 e138

e137

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c380 : 1
stoichiometry:c381 : 1
stoichiometry:c382 : 1

m147*m149*0.1

nodelay

--

true

0

false

PMID: 12773095,11313480,11278610,11971965,12228220,10747851 Consistent with the postulated E3-ligase function are new findings that SOCS1 targets JAK2, Tel-JAK2 and IRS1/2, as well as Vav, to degradation

Go back
338.0, 562.0
19.0, 19.0

p13

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000146 e15

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c37 : 1
stoichiometry:c42 : 1

m130*m15*0.1

nodelay

--

true

0

false

PMID: 12773095,8272872,11786531,10586060 The signal transducing chains gp130, LIFR and OSMR bind to JAK1, JAK2and TYK2

Go back
394.0, 670.0
19.0, 19.0

p13

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000148 e15

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c41 : 1
stoichiometry:c45 : 1

m132*m15*0.1

nodelay

--

true

0

false

PMID: 12773095,8272872,11786531,10586060 The signal transducing chains gp130, LIFR and OSMR bind to JAK1, JAK2and TYK2

Go back
767.0, 671.0
17.0, 17.0

p35

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e27 e41

MO000013119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m27*m42*0.1

nodelay

--

true

0

false

PMID: 12773095,9716487 All IL-6-type cytokines potently activate STAT3, and to a minor extent STAT1 through their common receptor subunit gp130

Go back
518.0, 386.0
19.0, 19.0

p13

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000146 e12

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m130*m12*0.1

nodelay

--

true

0

false

PMID: 12773095,8272872,11786531,10586060 The signal transducing chains gp130, LIFR and OSMR bind to JAK1, JAK2and TYK2

Go back
550.0, 510.0
19.0, 19.0

p13

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000148 e12

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m132*m12*0.1

nodelay

--

true

0

false

PMID: 12773095,8272872,11786531,10586060 The signal transducing chains gp130, LIFR and OSMR bind to JAK1, JAK2and TYK2

Go back
579.0, 619.0
18.0, 18.0

p13

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000145 e17

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m129*m17*0.1

nodelay

--

true

0

false

PMID: 12773095,8272872,11786531,10586060 The signal transducing chains gp130, LIFR and OSMR bind to JAK1, JAK2and TYK2

Go back
373.0, 121.0
21.0, 21.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016949 MO000058820

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m1859*m33847*0.1

nodelay

--

true

0

false

PMID: 12773095 IL-6, IL-11 and CNTF first bind specifically to their respective ¦Á-receptor subunits.

Go back
575.0, 671.0
18.0, 18.0

p13

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000146 e17

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m130*m17*0.1

nodelay

--

true

0

false

PMID: 12773095,8272872,11786531,10586060 The signal transducing chains gp130, LIFR and OSMR bind to JAK1, JAK2and TYK2

Go back
471.0, 723.0
18.0, 18.0

p13

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000148 e17

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m132*m17*0.1

nodelay

--

true

0

false

PMID: 12773095,8272872,11786531,10586060 The signal transducing chains gp130, LIFR and OSMR bind to JAK1, JAK2and TYK2

Go back
341.0, 445.0
21.0, 21.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000006538 e15

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m751*m15*0.1

nodelay

--

true

0

false

PMID: 12773095,11689697 The Src family kinase Hck has recently been shown to associate with an acidic region (amino acids 771?811) of gp130

Go back
410.0, 426.0
19.0, 19.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e15 MO000000011

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m15*m32*0.1

nodelay

--

true

0

false

PMID: 12773095,11689697 Deletion of these amino acids reduces IL-6-induced Hck kinase activity, ERK (extracellular-regulated kinase) activation, dephosphorylation of Pyk2 and proliferation of transfected pro- B Ba/F3 cells

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442.0, 618.0
19.0, 19.0

p24

p24

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

e15 MO000016852

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m15*m1785*0.1

nodelay

--

true

0

false

--

Go back
612.0, 316.0
20.0, 20.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000017758

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m15*m2515*0.1

nodelay

--

true

0

false

PMID: 12773095,12386808 Cdk9 (cyclin-dependent kinase 9) was also found to bind to gp130, and the association increased upon IL-6 stimulation of HEK 293 cells over-expressing gp130 and Cdk9

Go back
605.0, 433.0
21.0, 21.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000017065

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m15*m1957*0.1

nodelay

--

true

0

false

PMID: 12773095,12361954 PKCdelta (protein kinase Cdelta), a kinase implicated in serine phosphorylation of STAT3 (see below), has been found in a complex with gp130 upon IL-6 stimulation

Go back
569.0, 941.0
21.0, 21.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000148 MO000000145 MO000000146

G012485

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m132*m129*m130*0.1

nodelay

--

true

0

false

PMID: 12773095 Co-expression of JAK1, JAK2 and TYK2 substantially enhances the surface expression of the human OSMR.

Go back
902.0, 926.0
19.0, 19.0

p28

p28

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G012485

MO000016944

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c83 : 1

m95214*0.1

nodelay

--

true

0

false

PMID: 12773095 Co-expression of JAK1, JAK2 and TYK2 substantially enhances the surface expression of the human OSMR.

Go back
646.0, 998.0
19.0, 19.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000146

G010507

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m130*0.1

nodelay

--

true

0

false

PMID: 12773095 Similarly, JAK2 is crucial for EpoR surface expression.

Go back
710.0, 118.0
19.0, 19.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000003153 MO000016946

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m434*m1857*0.1

nodelay

--

true

0

false

PMID: 12773095 IL-6, IL-11 and CNTF first bind specifically to their respective ¦Á-receptor subunits.

Go back
914.0, 982.0
19.0, 19.0

p30

p30

cso30:i:ME_Translation

cso30:i:CC_NuclearChromosome

--

G010507

MO000000092

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c87 : 1

m93473*0.1

nodelay

--

true

0

false

PMID: 12773095 Similarly, JAK2 is crucial for EpoR surface expression.

Go back
940.0, 1056.0
23.0, 23.0

p31

p31

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m37*0.1

nodelay

--

true

0

false

--

Go back
622.0, 1022.0
19.0, 19.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000148

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m132*0.1

nodelay

--

true

0

false

PMID: 12773095,9342324 TYK2 is important for surface expression of the IFNalpha receptor 1 chain

Go back
214.0, 1098.0
19.0, 19.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017526 MO000013122

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m2322*m1360*0.1

nodelay

--

true

0

false

PMID: 12773095,12235142 In addition, STAT3 was reported to be associated with both caveolin-1 and heat-shock protein-90 in these rafts, as well as in the cytosol

Go back
250.0, 1078.0
19.0, 19.0

p33

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000013122 MO000021135

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m1360*m5516*0.1

nodelay

--

true

0

false

PMID: 12773095,12235142 In addition, STAT3 was reported to be associated with both caveolin-1 and heat-shock protein-90 in these rafts, as well as in the cytosol

Go back
355.0, 999.0
17.0, 17.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e24 MO000013122 MO000016882 MO000000289

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c236 : 1
stoichiometry:c237 : 1
stoichiometry:c101 : 1

m24*m1360*0.1

nodelay

--

true

0

false

PMID: 12773095,9716487 All IL-6-type cytokines potently activate STAT3, and to a minor extent STAT1 through their common receptor subunit gp130

Go back
263.0, 839.0
17.0, 17.0

p35

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e24 e41

MO000013119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m24*m42*0.1

nodelay

--

true

0

false

PMID: 12773095,9716487 All IL-6-type cytokines potently activate STAT3, and to a minor extent STAT1 through their common receptor subunit gp130

Go back
283.0, 631.0
17.0, 17.0

p35

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e16 e41

MO000013119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m16*m42*0.1

nodelay

--

true

0

false

PMID: 12773095,9716487 All IL-6-type cytokines potently activate STAT3, and to a minor extent STAT1 through their common receptor subunit gp130

Go back
235.0, 615.0
17.0, 17.0

p35

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e16 MO000013122

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m16*m1360*0.1

nodelay

--

true

0

false

PMID: 12773095,9716487 All IL-6-type cytokines potently activate STAT3, and to a minor extent STAT1 through their common receptor subunit gp130

Go back
699.0, 331.0
17.0, 17.0

p35

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000018968 e41

MO000013119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m3579*m42*0.1

nodelay

--

true

0

false

PMID: 12773095,9716487 All IL-6-type cytokines potently activate STAT3, and to a minor extent STAT1 through their common receptor subunit gp130

Go back
766.0, 114.0
19.0, 19.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016875 MO000018966

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m1797*m3577*0.1

nodelay

--

true

0

false

PMID: 12773095 Human OSM has the exceptional capability to recruit two different receptor complexes. It forms both LIFR?gp130 and OSMR?gp130 heterodimers.

Go back
735.0, 423.0
17.0, 17.0

p35

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013122 MO000018968

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c116 : 1
stoichiometry:c115 : 1

m1360*m3579*0.1

nodelay

--

true

0

false

PMID: 12773095,9716487 All IL-6-type cytokines potently activate STAT3, and to a minor extent STAT1 through their common receptor subunit gp130

Go back
743.0, 695.0
17.0, 17.0

p35

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013122 e27

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c117 : 1
stoichiometry:c119 : 1

m1360*m27*0.1

nodelay

--

true

0

false

PMID: 12773095,9716487 All IL-6-type cytokines potently activate STAT3, and to a minor extent STAT1 through their common receptor subunit gp130

Go back
506.0, 278.0
19.0, 19.0

p13

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000000145

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c120 : 1
stoichiometry:c122 : 1

m12*m129*0.1

nodelay

--

true

0

false

PMID: 12773095,8272872,11786531,10586060 The signal transducing chains gp130, LIFR and OSMR bind to JAK1, JAK2and TYK2

Go back
211.0, 875.0
17.0, 17.0

p35

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 e41

MO000013119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m30*m42*0.1

nodelay

--

true

0

false

PMID: 12773095,9716487 All IL-6-type cytokines potently activate STAT3, and to a minor extent STAT1 through their common receptor subunit gp130

Go back
231.0, 943.0
17.0, 17.0

p35

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 MO000013122

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1

m30*m1360*0.1

nodelay

--

true

0

false

PMID: 12773095,9716487 All IL-6-type cytokines potently activate STAT3, and to a minor extent STAT1 through their common receptor subunit gp130

Go back
818.0, 606.0
19.0, 19.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e27 MO000016876

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m27*m1798*0.1

nodelay

--

true

0

false

PMID: 12773095,7797460 In the cases of LIFR and OSMR, STAT3 and STAT1, as well as STAT5, activation has been observed, withOSMRbeing the most potent activator of STAT5

Go back
205.0, 781.0
21.0, 21.0

p46

p46

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e43

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 12773095, 8156998,7871433,7871432,8662795 The recruitment of STATs to the activated receptors has been shown to be mediated by their SH2 domain and requires the phosphorylation of receptor tyrosine motifs

Go back
198.0, 994.0
19.0, 19.0

p46

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e44

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 12773095, 8156998,7871433,7871432,8662795 The recruitment of STATs to the activated receptors has been shown to be mediated by their SH2 domain and requires the phosphorylation of receptor tyrosine motifs

Go back
834.0, 678.0
19.0, 19.0

p46

p48

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e45

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c136 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 12773095, 8156998,7871433,7871432,8662795 The recruitment of STATs to the activated receptors has been shown to be mediated by their SH2 domain and requires the phosphorylation of receptor tyrosine motifs

Go back
662.0, 666.0
19.0, 19.0

p45

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 MO000016876

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m30*m1798*0.1

nodelay

--

true

0

false

PMID: 12773095,7797460 In the cases of LIFR and OSMR, STAT3 and STAT1, as well as STAT5, activation has been observed, withOSMRbeing the most potent activator of STAT5

Go back
998.0, 114.0
19.0, 19.0

p4

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016875 MO000018967

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m1797*m3578*0.1

nodelay

--

true

0

false

PMID: 12773095 Human OSM has the exceptional capability to recruit two different receptor complexes. It forms both LIFR?gp130 and OSMR?gp130 heterodimers.

Go back
198.0, 722.0
19.0, 19.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 e41

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m24*m42*0.1

nodelay

--

true

0

false

PMID: 12773095,7871433,8662591,9182534,10068666 Whereas STAT3 binds to phospho (p)YXXQ motifs (Y767RHQ, Y814FKQ, Y905LPQ and Y915MPQ in gp130; Y981QPQ, Y1001KPQ and Y1028RPQ in LIFR) Whereas STAT3 binds to phospho (p)YXXQ motifs (Y767RHQ, Y814FKQ, Y905LPQ and Y915MPQ in gp130; Y981QPQ, Y1001KPQ and Y1028RPQ in LIFR)

Go back
302.0, 878.0
19.0, 19.0

p50

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000013122

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1
stoichiometry:c146 : 1

m24*m1360*0.1

nodelay

--

true

0

false

PMID: 12773095,7871433,8662591,9182534,10068666 Whereas STAT3 binds to phospho (p)YXXQ motifs (Y767RHQ, Y814FKQ, Y905LPQ and Y915MPQ in gp130; Y981QPQ, Y1001KPQ and Y1028RPQ in LIFR) Whereas STAT3 binds to phospho (p)YXXQ motifs (Y767RHQ, Y814FKQ, Y905LPQ and Y915MPQ in gp130; Y981QPQ, Y1001KPQ and Y1028RPQ in LIFR)

Go back
346.0, 1042.0
19.0, 19.0

p50

p52

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 MO000013122

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m30*m1360*0.1

nodelay

--

true

0

false

PMID: 12773095,7871433,8662591,9182534,10068666 Whereas STAT3 binds to phospho (p)YXXQ motifs (Y767RHQ, Y814FKQ, Y905LPQ and Y915MPQ in gp130; Y981QPQ, Y1001KPQ and Y1028RPQ in LIFR) Whereas STAT3 binds to phospho (p)YXXQ motifs (Y767RHQ, Y814FKQ, Y905LPQ and Y915MPQ in gp130; Y981QPQ, Y1001KPQ and Y1028RPQ in LIFR)

Go back
242.0, 1246.0
19.0, 19.0

p53

p53

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e46

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 12773095,7690989,8626374 Subsequent to receptor binding, the STAT factors are phosphorylated on a single tyrosine residue (Tyr701 in STAT1 and Tyr705 in STAT3)

Go back
799.0, 511.0
17.0, 17.0

p35

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e18 e41

MO000013119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1
stoichiometry:c152 : 1

m18*m42*0.1

nodelay

--

true

0

false

PMID: 12773095,9716487 All IL-6-type cytokines potently activate STAT3, and to a minor extent STAT1 through their common receptor subunit gp130

Go back
826.0, 458.0
19.0, 19.0

p45

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e18 MO000016876

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m18*m1798*0.1

nodelay

--

true

0

false

PMID: 12773095,7797460 In the cases of LIFR and OSMR, STAT3 and STAT1, as well as STAT5, activation has been observed, withOSMRbeing the most potent activator of STAT5

Go back
863.0, 555.0
17.0, 17.0

p35

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e18 MO000013122

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m18*m1360*0.1

nodelay

--

true

0

false

PMID: 12773095,9716487 All IL-6-type cytokines potently activate STAT3, and to a minor extent STAT1 through their common receptor subunit gp130

Go back
798.0, 742.0
19.0, 19.0

p45

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 MO000016876

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m20*m1798*0.1

nodelay

--

true

0

false

PMID: 12773095,7797460 In the cases of LIFR and OSMR, STAT3 and STAT1, as well as STAT5, activation has been observed, withOSMRbeing the most potent activator of STAT5

Go back
827.0, 775.0
17.0, 17.0

p35

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 e41

MO000013119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c164 : 1

m20*m42*0.1

nodelay

--

true

0

false

PMID: 12773095,9716487 All IL-6-type cytokines potently activate STAT3, and to a minor extent STAT1 through their common receptor subunit gp130

Go back
779.0, 795.0
17.0, 17.0

p35

p59

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 MO000013122

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m20*m1360*0.1

nodelay

--

true

0

false

PMID: 12773095,9716487 All IL-6-type cytokines potently activate STAT3, and to a minor extent STAT1 through their common receptor subunit gp130

Go back
202.0, 270.0
19.0, 19.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m5*m14*0.1

nodelay

--

true

0

false

PMID: 12773095 IL-6 and IL-11 are the only IL-6-type cytokines that signal via gp130 homodimers.

Go back
246.0, 1322.0
19.0, 19.0

p53

p60

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e47

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 12773095,7690989,8626374 Subsequent to receptor binding, the STAT factors are phosphorylated on a single tyrosine residue (Tyr701 in STAT1 and Tyr705 in STAT3)

Go back
255.0, 1379.0
19.0, 19.0

p53

p61

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e48

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c173 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 12773095,7690989,8626374 Subsequent to receptor binding, the STAT factors are phosphorylated on a single tyrosine residue (Tyr701 in STAT1 and Tyr705 in STAT3)

Go back
342.0, 1118.0
20.0, 20.0

p62

p62

cso30:i:ME_Methylation

cso30:i:CC_Cytosol

--

e65 e41

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c175 : 1
stoichiometry:c176 : 1

m66*m42*0.1

nodelay

--

true

0

false

PMID: 12773095 Arg31 of STAT1 was found to be specifically methylated by PRMT-1 (protein arginine methyltransferase-1).

Go back
513.0, 1217.0
21.0, 21.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e65 e37

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c178 : 1
stoichiometry:c179 : 1

m66*m38*0.1

nodelay

--

true

0

false

PMID: 12773095,9029147 Therewas earlier evidence for a link between PRMT and the JAK/STAT pathway: PRMT-1 was found to associate with the IFN¦Á/¦Â receptor 1; and also a JAK-associated protein was identified as PRMT-5

Go back
509.0, 1273.0
21.0, 21.0

p63

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e65 e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m66*m69*0.1

nodelay

--

true

0

false

PMID: 12773095,9029147 Therewas earlier evidence for a link between PRMT and the JAK/STAT pathway: PRMT-1 was found to associate with the IFN¦Á/¦Â receptor 1; and also a JAK-associated protein was identified as PRMT-5

Go back
678.0, 814.0
19.0, 19.0

p65

p65

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e70 e79

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c203 : 1
stoichiometry:c189 : 1

m71*m80*0.1

nodelay

--

true

0

false

PMID: 12773095,9918120 Indeed, extracellularsignal- dependent translocation of STAT1 in response to IFN requires the nuclear import receptor NPI-1/importin-¦Á5, which mediates translocation via a Ran-dependent mechanism PMID: 12773095,11927559,11823427 Later it turned out that residues located within this short sequence stretch are important for the interaction of STAT1 with the import receptor importin-¦Á5 and therefore for nuclear import of STAT1

Go back
565.0, 865.0
21.0, 21.0

p66

p66

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e75 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c185 : 1
stoichiometry:c186 : 1

m76*m73*0.1

nodelay

--

true

0

false

PMID: 12773095,9918120 Indeed, extracellularsignal- dependent translocation of STAT1 in response to IFN requires the nuclear import receptor NPI-1/importin-¦Á5, which mediates translocation via a Ran-dependent mechanism

Go back
953.0, 961.0
21.0, 21.0

p66

p67

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e75 e71

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1

m76*m72*0.1

nodelay

--

true

0

false

PMID: 12773095,9918120 Indeed, extracellularsignal- dependent translocation of STAT1 in response to IFN requires the nuclear import receptor NPI-1/importin-¦Á5, which mediates translocation via a Ran-dependent mechanism

Go back
726.0, 838.0
19.0, 19.0

p65

p68

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e70 e74 MO000013119

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c194 : 1
stoichiometry:c195 : 1
stoichiometry:c196 : 1

m71*m75*m1357*0.1

nodelay

--

true

0

false

PMID: 12773095,9918120 Indeed, extracellularsignal- dependent translocation of STAT1 in response to IFN requires the nuclear import receptor NPI-1/importin-¦Á5, which mediates translocation via a Ran-dependent mechanism

Go back
602.0, 1102.0
19.0, 19.0

p69

p69

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e75 e78

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c198 : 1
stoichiometry:c199 : 1

m76*m79*0.1

nodelay

--

true

0

false

PMID: 12773095,11080165,10973496 Sensitivity to leptomycin suggests that nuclear export of STAT1 involves the nuclear export receptor CRM-1 that also acts in a Randependent manner

Go back
298.0, 362.0
19.0, 19.0

p6

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 e14

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m6*m14*0.1

nodelay

--

true

0

false

PMID: 12773095 IL-6 and IL-11 are the only IL-6-type cytokines that signal via gp130 homodimers.

Go back
510.0, 1002.0
19.0, 19.0

p70

p70

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e77 e76

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c201 : 1
stoichiometry:c202 : 1

m78*m77*0.1

nodelay

--

true

0

false

PMID: 12773095,11080165,10973496 Sensitivity to leptomycin suggests that nuclear export of STAT1 involves the nuclear export receptor CRM-1 that also acts in a Randependent manner

Go back
610.0, 810.0
19.0, 19.0

p71

p71

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e73 MO000013119

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1
stoichiometry:c204 : 1

m74*m1357*0.1

nodelay

--

true

0

false

PMID: 12773095,11927559,11823427 Later it turned out that residues located within this short sequence stretch are important for the interaction of STAT1 with the import receptor importin-¦Á5 and therefore for nuclear import of STAT1

Go back
562.0, 278.0
19.0, 19.0

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 e80

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c206 : 1
stoichiometry:c207 : 1

m25*m81*0.1

nodelay

--

true

0

false

PMID: 12773095,11016927 It has been demonstrated that the adaptor protein Shc (SH2- and collagen-homology-domain-containing protein)is recruited to the receptor via Tyr861 in the cytoplasmic region of the OSMR

Go back
189.0, 557.0
21.0, 21.0

p46

p73

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e22

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c208 : 1
stoichiometry:c209 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 12773095, 8156998,7871433,7871432,8662795 The recruitment of STATs to the activated receptors has been shown to be mediated by their SH2 domain and requires the phosphorylation of receptor tyrosine motifs

Go back
202.0, 642.0
19.0, 19.0

p74

p74

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e83 e84

e85 e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c211 : 1
stoichiometry:c212 : 1
stoichiometry:c220 : 1

m85*m86*0.1

nodelay

--

true

0

false

PMID: 12773095,9794795 SHP2 is rapidly recruited to tyrosine-phosphorylated gp130 and becomes also phosphorylated in a JAK1-dependent manner

Go back
195.0, 695.0
17.0, 17.0

p75

p75

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c214 : 1

m87*0.1

nodelay

--

true

0

false

PMID: 12773095,9794795 SHP2 is rapidly recruited to tyrosine-phosphorylated gp130 and becomes also phosphorylated in a JAK1-dependent manner

Go back
276.0, 716.0
23.0, 23.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e87 e86

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c216 : 1
stoichiometry:c217 : 1

m89*m88*0.1

nodelay

--

true

0

false

PMID: 12773095,9195977,8596638,9885561 According to the current viewof the SHP2-dependent activation of MAPKs adopted from EGF and PDGF (platelet-derived growth factor) signal transduction, SHP2 links the Grb2?SOS (growthfactor- receptor-bound protein/Son of Sevenless) complex and/or Gab1 (Grb2-associated binder-1) to gp130

Go back
295.0, 803.0
18.0, 18.0

p76

p77

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e86 e89

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1
stoichiometry:c221 : 1

m88*m91*0.1

nodelay

--

true

0

false

PMID: 12773095,9195977,8596638,9885561 According to the current viewof the SHP2-dependent activation of MAPKs adopted from EGF and PDGF (platelet-derived growth factor) signal transduction, SHP2 links the Grb2?SOS (growthfactor- receptor-bound protein/Son of Sevenless) complex and/or Gab1 (Grb2-associated binder-1) to gp130

Go back
922.0, 310.0
19.0, 19.0

p78

p78

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e82

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c223 : 1

m84*0.1

nodelay

--

true

0

false

PMID: 12773095 The alternative Shc-mediated pathway mediated by OSM also involves the adaptor protein Grb2 which is recruited to Tyr317- phosphorylated Shc

Go back
897.0, 469.0
17.0, 17.0

p79

p79

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e81 e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c225 : 1
stoichiometry:c226 : 1

m83*m93*0.1

nodelay

--

true

0

false

PMID: 12773095 The alternative Shc-mediated pathway mediated by OSM also involves the adaptor protein Grb2 which is recruited to Tyr317- phosphorylated Shc.

Go back
1153.0, 241.0
21.0, 21.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018967 MO000008548

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m3578*m1080*0.1

nodelay

--

true

0

false

PMID: 12773095 The remaining IL-6 type cytokines signal via heterodimers of either gp130 and the LIFR (LIF, CNTF, CT-1 and CLC) or gp130 and the OSMR (OSM).

Go back
975.0, 527.0
17.0, 17.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e92 MO000016777

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c228 : 1
stoichiometry:c229 : 1

m94*m1720*0.1

nodelay

--

true

0

false

PMID: 12773095 Finally, recruitment of SOS to the receptor complex at the membrane allows Ras activation, which in turn leads to the activation of the Ras?Raf?MAPK cascade

Go back
886.0, 598.0
19.0, 19.0

p81

p81

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e95 e93

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c230 : 1
stoichiometry:c232 : 1

m97*m95*0.1

nodelay

--

true

0

false

PMID: 12773095 Finally, recruitment of SOS to the receptor complex at the membrane allows Ras activation, which in turn leads to the activation of the Ras?Raf?MAPK cascade

Go back
678.0, 542.0
19.0, 19.0

p82

p82

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e94 e96

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c234 : 1
stoichiometry:c235 : 1

m96*m98*0.1

nodelay

--

true

0

false

PMID: 12773095 Finally, recruitment of SOS to the receptor complex at the membrane allows Ras activation, which in turn leads to the activation of the Ras?Raf?MAPK cascade

Go back
930.0, 1122.0
19.0, 19.0

p83

p83

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

MO000016882 G011948

MO000017121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c239 : 1
stoichiometry:c240 : 1

m155666*m94757*0.1

nodelay

--

true

0

false

PMID: 12773095,10453004 A similar mechanism has been discovered for IFN¦Ã signalling, where LPS inhibits IFN¦Ã -dependent STAT1 activation also via the induction of SOCS3

Go back
406.0, 1214.0
19.0, 19.0

p84

p84

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016665 e41 G011948

MO000013119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c242 : 1
stoichiometry:c244 : 1
stoichiometry:c243 : 1

m1639*m42*0.1

nodelay

--

true

0

false

PMID: 12773095,10453004 A similar mechanism has been discovered for IFN¦Ã signalling, where LPS inhibits IFN¦Ã -dependent STAT1 activation also via the induction of SOCS3

Go back
425.0, 1233.0
21.0, 21.0

p85

p85

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 MO000099682

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c246 : 1
stoichiometry:c247 : 1

m41*m72733*0.1

nodelay

--

true

0

false

PMID: 12773095,9037008,8986769,10464260 The C-terminal transactivation domains of STAT1, STAT3 and STAT5 are known to interact with CBP/p300

Go back
329.0, 1185.0
21.0, 21.0

p85

p86

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000099682 MO000013119

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c248 : 1
stoichiometry:c249 : 1
stoichiometry:c250 : 1

m72733*m1357*0.1

nodelay

--

true

0

false

PMID: 12773095,9037008,8986769,10464260 The C-terminal transactivation domains of STAT1, STAT3 and STAT5 are known to interact with CBP/p300

Go back
589.0, 1321.0
21.0, 21.0

p85

p87

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 MO000099682

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c252 : 1
stoichiometry:c253 : 1

m43*m72733*0.1

nodelay

--

true

0

false

PMID: 12773095,9037008,8986769,10464260 The C-terminal transactivation domains of STAT1, STAT3 and STAT5 are known to interact with CBP/p300

Go back
497.0, 1441.0
21.0, 21.0

p85

p88

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 MO000019984

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c255 : 1
stoichiometry:c256 : 1

m41*m4512*0.1

nodelay

--

true

0

false

PMID: 12773095,9037008,8986769,10464260 The C-terminal transactivation domains of STAT1, STAT3 and STAT5 are known to interact with CBP/p300

Go back
653.0, 1361.0
21.0, 21.0

p85

p89

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000013119 MO000019984

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c257 : 1
stoichiometry:c258 : 1
stoichiometry:c259 : 1

m1357*m4512*0.1

nodelay

--

true

0

false

PMID: 12773095,9037008,8986769,10464260 The C-terminal transactivation domains of STAT1, STAT3 and STAT5 are known to interact with CBP/p300

Go back
1161.0, 349.0
21.0, 21.0

p8

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018967 e11

MO000018968

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c25 : 1
stoichiometry:c27 : 1

m3578*m11*0.1

nodelay

--

true

0

false

PMID: 12773095 The remaining IL-6 type cytokines signal via heterodimers of either gp130 and the LIFR (LIF, CNTF, CT-1 and CLC) or gp130 and the OSMR (OSM).

Go back
697.0, 1305.0
21.0, 21.0

p85

p90

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 MO000019984

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c261 : 1
stoichiometry:c262 : 1

m43*m4512*0.1

nodelay

--

true

0

false

PMID: 12773095,9037008,8986769,10464260 The C-terminal transactivation domains of STAT1, STAT3 and STAT5 are known to interact with CBP/p300

Go back
294.0, 1290.0
19.0, 19.0

p91

p91

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e99 MO000017277

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c264 : 1
stoichiometry:c265 : 1

m101*m2131*0.1

nodelay

--

true

0

false

PMID: 12773095,9989503 This interaction is further modulated by Nmi (N-Myc interactor) which augments CBP recruitment to STAT1 and STAT5, and potentiates IL-2 and IFN¦Ã signalling

Go back
358.0, 1382.0
19.0, 19.0

p91

p92

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e100 MO000017277

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c266 : 1
stoichiometry:c267 : 1
stoichiometry:c268 : 1

m102*m2131*0.1

nodelay

--

true

0

false

PMID: 12773095,9989503 This interaction is further modulated by Nmi (N-Myc interactor) which augments CBP recruitment to STAT1 and STAT5, and potentiates IL-2 and IFN¦Ã signalling

Go back
554.0, 1254.0
19.0, 19.0

p93

p93

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011662 MO000017061

MO000017277

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c270 : 1
stoichiometry:c271 : 1
stoichiometry:c269 : 1

m94491*m1954*0.1

nodelay

--

true

0

false

PMID: 12773095 Interestingly, Nmi itself is induced by IL-2 and IFN¦Ã , indicating a positive feedback loop within this signal transduction.

Go back
642.0, 1282.0
19.0, 19.0

p93

p94

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000016665 G011662

MO000017277

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c273 : 1
stoichiometry:c274 : 1
stoichiometry:c272 : 1

m1639*m94491*0.1

nodelay

--

true

0

false

PMID: 12773095 Interestingly, Nmi itself is induced by IL-2 and IFN¦Ã , indicating a positive feedback loop within this signal transduction.

Go back
799.0, 379.0
18.0, 18.0

p95

p95

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000031185 e42

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c275 : 1
stoichiometry:c276 : 1
stoichiometry:c277 : 1

m10730*m43*0.1

nodelay

--

true

0

false

PMID: 12773095,11726519 The nuclear receptor co-repressor SMRT (silencing mediator of retinoic and thyroid hormone receptors) is a potential binding partner for STAT5 and represses STAT5-dependent transcription

Go back
755.0, 1159.0
17.0, 17.0

p96

p96

cso30:i:ME_Binding

cso30:i:CC_Nucleolus

--

e108 e107

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c278 : 1
stoichiometry:c279 : 1
stoichiometry:c280 : 1

m110*m109*0.1

nodelay

--

true

0

false

PMID: 12773095,12456685 Furthermore, FKHR and STAT3 can be co-immunoprecipitated and co-localize in the nucleus of IL-6-treated HepG2 cells

Go back
781.0, 973.0
19.0, 19.0

p97

p97

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5 e109

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c281 : 1
stoichiometry:c283 : 1
stoichiometry:c282 : 1

m5*m111*0.1

nodelay

--

true

0

false

PMID:12773095 These results indicate that FKHR can modulate the IL-6-induced transcriptional activity by enhancing STAT3 action.

Go back
623.0, 1135.0
17.0, 17.0

p98

p98

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

MO000000048 e108

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c284 : 1
stoichiometry:c285 : 1
stoichiometry:c286 : 1

m113*m110*0.1

nodelay

--

true

0

false

PMID: 12773095,1372389,10462375 FKHR is inactivated by Akt/protein kinase B-mediated serine/threonine phosphorylation.

Go back
729.0, 1089.0
21.0, 21.0

p99

p99

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e112 e107

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c287 : 1
stoichiometry:c288 : 1
stoichiometry:c289 : 1

m115*m109*0.1

nodelay

--

true

0

false

PMID: 12773095 STAT3 and EZI physically interact as demonstrated by co-immunoprecipitation.

Go back
226.0, 136.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
793.0, 124.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.0, 1011.2639240088533

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
365.0, 927.8938353482613

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
154.0, 862.122896687244

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
269.0, 784.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.0, 831.2439429085273

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
155.0, 399.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
270.0, 655.8629774954745

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
297.0, 648.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
152.0, 399.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
244.48332601895532, 639.9853864001312

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.8308170454446, 140.02316458331507

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
248.0, 632.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
723.8600777402186, 343.48969054428085

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
280.0, 353.60220244860204

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
412.2659574620215, 348.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
278.0, 446.2341704273326

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
393.8621860479413, 440.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
759.995679988885, 420.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
766.5573541790346, 714.5826963864844

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
280.0, 714.4109540143046

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
399.0185744968183, 709.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
785.0, 130.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
280.0, 288.28300858642837

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
532.7873373466687, 202.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.09309917709624, 227.9249690339478

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
146.0, 899.5633739427296

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
227.15135438863334, 784.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.0, 834.3861999450876

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
151.0, 966.8335884449156

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
245.87183263447096, 967.4667648496245

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
248.0, 914.4151336375552

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.1784636870352, 631.0978286169798

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
846.0, 124.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
660.0, 520.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.3995009355511, 573.9900187110228

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
152.0, 809.2653354651449

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
152.64280339782485, 802.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
147.0, 1020.4168805256332

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.17484710779348, 1013.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
853.0, 697.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
859.4391770844088, 699.7473148700739

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
151.0, 689.101282112915

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
651.0, 524.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1015.0938134100054, 140.37755505462826

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
681.0, 568.9571543086322

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
148.0, 748.7779250754903

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
223.65640235470275, 742.4376015698018

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
143.08913003548136, 741.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
154.0, 899.4167787461936

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.0, 904.615539172762

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
151.12540203639387, 897.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
151.0, 1057.280738605333

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.0, 1028.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
159.69098446834937, 1061.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1017.0, 131.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
823.4947321178189, 525.7980333239857

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
280.0, 527.3807891767756

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
418.38611198598835, 527.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
851.8889299636784, 477.06726492320496

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
660.0, 471.91825986289587

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
826.1474325785512, 477.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
887.6697288678929, 568.2749195794597

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
280.0, 575.8470299718939

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
398.55189421084793, 570.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.9935648918745, 752.3208119689046

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
227.32842387290043, 215.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.0, 524.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
809.0, 573.9748095637825

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
851.9825400252605, 765.0

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
280.0, 772.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.95934239704286, 785.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
803.9441833872287, 765.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
280.0, 811.1156747399855

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
399.75042163582054, 806.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
150.0, 1234.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
154.74388876723103, 1265.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
157.0, 280.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
150.0, 1295.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
162.99086913606038, 1341.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
155.0, 1348.0

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
164.0659023220581, 1398.0

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
369.9751851892278, 1129.6296198833602

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
271.0, 784.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
361.0, 1054.0312760219992

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
454.0, 1143.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.0, 1228.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 1229.0

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
166.43659263668613, 288.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
452.0, 1143.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.9394589517061, 1285.9823398363976

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
530.0, 1286.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
704.9997568213511, 824.0623762715115

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
593.9929869797618, 876.3349016890961

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
569.0, 809.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.0, 784.5911602671604

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
636.2560717419874, 777.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
412.0, 820.3229688096263

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.0, 833.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
320.91794638954457, 226.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
957.0, 900.0

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
908.0, 880.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
869.6568542494924, 877.6568542494924

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.992610551477, 828.0

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.9284852929829, 850.0672960971323

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
412.0, 829.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 857.0

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.7449892193672, 900.0

c197

c197

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
552.0, 1113.9531617649475

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
574.9835478570981, 1090.9025708613196

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
208.46977617561177, 153.98619498539998

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
157.0, 287.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
528.7431017633522, 1028.0703033307766

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.4538832385473, 933.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
398.41301980074445, 921.7825910378433

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
513.0, 827.7053366017338

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.4746804629865, 824.0

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.0, 215.0

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.0, 304.7513416849957

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.0, 193.09004271568452

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
154.0, 579.3934230932867

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
158.4114641099937, 578.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
163.99029738637822, 372.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
154.0, 652.0

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.68199782849993, 624.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
160.4, 660.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
154.0, 704.0

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
160.23209348210335, 711.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
305.59233539359496, 687.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
154.0, 731.2942002165319

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
161.15541752799933, 734.0

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
154.0, 756.0

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
305.68497529458784, 547.0

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1057.0, 213.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.3600735024118, 661.0

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
165.83797464072018, 814.0

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
933.7031504823708, 208.0

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 327.0

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
921.9853479730496, 465.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.0, 462.0

c225

c225

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
914.0, 480.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
999.9741116400947, 525.0

c227

c227

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
916.0, 537.4062548214393

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 539.0

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1135.0, 268.89092722707045

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
912.9568662751046, 585.0

c230

c230

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
758.0, 606.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
797.3292586792176, 612.0

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
701.423526288381, 566.8809321199312

c233

c233

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
631.0, 545.0

c234

c234

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
681.9531617649475, 499.9430147078954

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
375.99149996998926, 1009.2606299859485

c236

c236

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
375.99924061859235, 992.0

c237

c237

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
956.7500753214106, 1066.0

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
850.0, 1121.0

c239

c239

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1143.6749240125703, 246.2573305919324

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
903.5777087639997, 1141.0

c240

c240

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
432.96029752167993, 1145.0

c241

c241

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
272.0, 784.0

c242

c242

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.34193323053205, 847.992689263687

c243

c243

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.88337377405065, 1122.0

c244

c244

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
382.0, 920.0

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
450.4381173212795, 1259.8674423729594

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
427.22669863865275, 1254.0

c247

c247

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.26488677998634, 1208.9750571488128

c248

c248

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.28177478647893, 840.0

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.0, 204.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
340.0, 1206.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
605.219273202871, 566.0

c251

c251

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.0, 1336.7354436625492

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.0, 1342.0

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
383.0, 920.0

c254

c254

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
478.0, 1406.0

c255

c255

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
518.0, 1453.0

c256

c256

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
406.0, 840.0

c257

c257

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
482.0, 1374.0208260313957

c258

c258

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
674.0, 1380.0

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1055.0, 221.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
711.1987600955919, 566.0

c260

c260

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
482.0, 1322.572063364447

c261

c261

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
714.0, 1326.0

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
319.6098187424604, 1279.0

c263

c263

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
304.0, 1317.0

c264

c264

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.0, 1305.0

c265

c265

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
384.9957730662131, 1392.2600251403646

c266

c266

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
314.0, 1365.0

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
377.0, 1398.0

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
321.5110105270929, 1268.0

c269

c269

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1140.7736221307564, 370.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
576.8441746598661, 1208.0

c270

c270

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.9828822425669, 1221.0

c271

c271

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
321.8519247362056, 1294.0

c272

c272

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
668.7371487086155, 1147.0

c273

c273

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
620.0, 1208.0

c274

c274

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
814.8479626207359, 337.0

c275

c275

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
809.7483815938717, 404.96491839192055

c276

c276

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
782.5189395904805, 337.1845016638977

c277

c277

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
714.0, 1124.0

c278

c278

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.0, 1168.0

c279

c279

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1216.0, 478.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
765.0, 1082.9439061935595

c280

c280

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
313.0, 222.0

c281

c281

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
800.0, 990.0

c282

c282

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
778.0, 999.8730161395608

c283

c283

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
582.0, 1151.3636881022717

c284

c284

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
647.4374520037236, 1120.0

c285

c285

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
637.0, 1152.0

c286

c286

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.4905814614565, 1115.8183773696032

c287

c287

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
714.0, 1117.2775040309043

c288

c288

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
625.8193133235189, 1075.6906623402203

c289

c289

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1053.0, 221.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
380.0, 1527.0

c290

c290

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
413.0, 1564.0

c291

c291

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
483.0, 1569.0

c292

c292

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
491.0, 1522.0

c293

c293

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
549.0, 1592.0

c294

c294

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.0, 1568.406376290639

c295

c295

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
677.0, 1510.0

c296

c296

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
689.0, 1556.420470664982

c297

c297

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
762.0, 1500.0180979353481

c298

c298

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
737.0, 486.0

c299

c299

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
218.0, 143.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1139.5212577361842, 470.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
803.0, 1420.5538553641522

c300

c300

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
766.6568542494924, 1318.6568542494924

c301

c301

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
755.0, 1225.6845141153165

c302

c302

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
782.0, 1136.7932216296308

c303

c303

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
720.0, 1128.7384586046758

c304

c304

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
809.0, 1105.104939246337

c305

c305

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
313.0, 224.0

c306

c306

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
680.0, 424.99001871102274

c307

c307

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
659.0, 383.0

c308

c308

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
693.0, 395.0110163756475

c309

c309

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
963.5065350913145, 221.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.0, 1235.509867769654

c310

c310

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
835.490188052155, 1269.0

c311

c311

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
884.9496209621675, 1221.0

c312

c312

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
932.9850482685217, 1289.0

c313

c313

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
898.0, 1229.0

c314

c314

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.4129027473432, 1312.0

c315

c315

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.9993254353038, 1340.0

c316

c316

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
896.0, 1229.0

c317

c317

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.0, 1344.0

c318

c318

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1004.9945690215859, 1404.2947306551737

c319

c319

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
977.5843608466533, 649.5450875324341

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.0, 1229.0

c320

c320

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.488448574556, 1349.8148069110032

c321

c321

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
758.0, 608.0

c322

c322

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.0, 665.9697920395747

c323

c323

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
898.0, 655.0

c324

c324

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
155.0, 861.0

c325

c325

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
163.16416443227354, 1240.0

c326

c326

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
162.0, 1546.6568542494924

c327

c327

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
230.71715571022045, 1486.0

c328

c328

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
233.0, 1466.2267985930148

c329

c329

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
970.0, 651.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
335.43968576139144, 1476.0

c330

c330

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
162.0, 1506.3329019758976

c331

c331

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
278.91825986289587, 1504.0

c332

c332

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.0, 1473.0

c333

c333

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
616.9540091220535, 1485.0

c334

c334

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
609.0, 1501.0

c335

c335

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.7568258512991, 215.0

c336

c336

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
279.0, 784.0

c337

c337

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.885143449429, 1463.9932582089723

c338

c338

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
909.0, 1448.0

c339

c339

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
157.0, 436.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
748.0, 930.0

c340

c340

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
643.0, 942.228497126079

c341

c341

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.68, 943.0

c342

c342

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
802.9204647935734, 951.8926526384706

c343

c343

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
623.0, 989.5699763999032

c344

c344

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.0, 991.0

c345

c345

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
719.0, 1086.8874480940947

c346

c346

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
805.0, 1051.2399915200253

c347

c347

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
801.5272135529391, 1084.696974271444

c348

c348

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
431.10793806975215, 441.0

c349

c349

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.0, 465.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
154.0, 501.0597326351071

c350

c350

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
163.86486400007954, 258.44089792778465

c351

c351

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
313.0, 223.0

c352

c352

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
964.9064085111415, 1154.0

c353

c353

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
905.0, 1192.8308615039637

c354

c354

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
953.0, 1189.0

c355

c355

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
154.0, 662.0

c356

c356

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.0, 1229.0

c357

c357

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1021.0, 1508.0

c358

c358

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
869.8393213929166, 1576.4791880593903

c359

c359

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
163.016770142732, 474.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
865.7444195949728, 1229.0

c360

c360

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
811.5233999492388, 1569.0

c361

c361

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
797.258578314322, 1229.0

c362

c362

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
682.0, 1586.5414436895273

c363

c363

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.0, 1577.0

c364

c364

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
506.31242957138693, 445.0

c365

c365

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.0, 494.65685424949237

c366

c366

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
466.5562507448574, 489.0

c367

c367

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
395.5320612097545, 456.17805987788813

c368

c368

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
391.4774941305495, 281.0

c369

c369

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
160.0, 342.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.0, 401.6248890229315

c370

c370

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
466.0, 601.0

c371

c371

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
373.0, 664.9286753566283

c372

c372

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.0, 410.1809118774485

c373

c373

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
471.0, 577.8738604149509

c374

c374

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
575.51797989205, 592.8546633949096

c375

c375

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.0, 408.8633881836398

c376

c376

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
468.0, 419.769862720718

c377

c377

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
592.9195959492894, 377.0

c378

c378

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
585.0, 400.10773433736216

c379

c379

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.0, 304.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
471.0, 428.62350237847164

c380

c380

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
807.157225063693, 340.0

c381

c381

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.0, 403.5502913457039

c382

c382

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
161.80352801654166, 574.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
402.0, 132.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.88163215600105, 281.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
160.0, 344.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
154.32264653156685, 581.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
238.0, 681.715074917485

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
358.42562925821557, 379.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
159.5637559696664, 689.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
790.2042806557512, 692.0504357776999

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
280.0, 683.4225473798948

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.44932286935307, 684.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.0, 281.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
384.0, 150.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.0503201829345, 206.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.0, 402.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
238.0, 528.7576545842293

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
574.766310496754, 210.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
569.0, 526.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
280.0, 304.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
603.4851017589798, 249.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
156.83119661198546, 636.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.0, 281.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.201229712711, 250.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
390.0, 142.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
593.0, 686.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
238.0, 697.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
495.3618125111218, 250.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.8894189236468, 741.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
159.0, 347.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
160.0, 335.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
163.25446617597257, 461.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
160.0, 333.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
428.39152084838906, 379.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.0, 438.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
640.0, 128.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
160.0, 340.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
452.0, 645.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
461.0, 636.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
160.0, 326.0353978835685

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
637.8874480940947, 294.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
157.74306962336576, 205.01118691515993

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
160.0, 331.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
633.7425800543061, 449.0130708141196

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
565.6994371546483, 210.8174109113824

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
238.0, 703.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
660.0, 143.08812072874562

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.0, 304.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
422.0, 281.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
590.0, 953.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
921.0, 943.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
698.0, 937.8577715147383

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
423.0, 281.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
665.0, 1008.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
933.0, 999.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
741.0, 993.6452893461455

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
238.0, 704.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
720.0, 137.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
641.0, 1036.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
727.0, 1068.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
963.0, 1078.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
224.0, 1125.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
232.75879265156323, 1036.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
202.8041362749238, 1068.037652108609

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
261.9457031182809, 1036.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.0, 1088.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
260.0, 1097.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
154.0, 1000.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back