1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/12860525.csml convertedTime:2009.07.01.10:41

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title PI3K and negative regulation of TLR signaling.
Authors Fukao T, Koyasu S.
Affiliation Department of Microbiology and Immunology, Keio University School of Medicine,35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan.
Abstract Excessive immune responses are detrimental to the host and negative feedbackregulation is crucial for the maintenance of immune-system integrity. Recentstudies have shown that phosphoinositide 3-kinase (PI3K) is an endogenoussuppressor of interleukin-12 (IL-12) production triggered by Toll-like receptor(TLR) signaling and limits excessive Th1 polarization. Unlike IRAK-M (IL-1receptor-associated kinase-M) and SOCS-1 (suppressor of cytokine signaling-1)that are induced by TLR signaling and function during the second or continuousexposure to stimulation, PI3K functions at the early phase of TLR signaling andmodulates the magnitude of the primary activation. Thus, PI3K, IRAK-M and SOCS-1have unique roles in the gate-keeping system, preventing excessive innate immuneresponses.
PMID 12860525
Model Abstract

Entity

MO000000022:p38 MO000000048:AKT MO000000058:NF-kappaB MO000000079:ASK1 MO000000166:Rac1 MO000000193:RelA-p65 MO000000212:TRAF6 MO000000213:IRAK MO000000248:IKK MO000016573:MyD88 MO000016574:TAK1 MO000016882:LPS MO000016966:MKK3 MO000017265:IL-12 MO000017608:PI3K family MO000018743:RANKL MO000019005:MKK6 MO000019394:TLR4 MO000019397:TLR2 MO000019406:Tollip MO000019479:protein remnants e1: e10: e11:PI3K family e12:peptidoglycan e13:CD40L e14:CpG ODN e15:LPS:TLR4:MyD88 e16:LPS:TLR4:MyD88:IRAK e17:LPS:TLR4:MyD88:IRAK{p} e18:LPS:TLR4:MyD88:IRAK{p}:Tollip e19:LPS:TLR4:MyD88:IRAK{p}:Tollip:TRAF6 e2: e20:TAK1{active} e21:IKK{active} e22:TLR2 ligand e23:TLR2 ligand: TLR2 e24:Rac1{active} e25:LPS:TLR4:MYD88:PI3K e26:NF-kappaB{active} e27:MAP3K e28:MAP3K{active} e29:MKK3{active} e3: e30:p38{active} e31:MKK6{active} e32:AKT{active} e33:ASK1{p} e34:MEKK3 e35:RelA-p65 e36:IkappaB-alpha:NF-kappaB e37:IkappaB-alpha{p}:NF-kappaB e38:NF-kappaB{active} e39:IL-12p40 e4: e40:IL-12p35 e5:LPS:TLR4 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IL-12 e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p4 p5 p6 p7 p8 p9
Model Detail
536.0, 1072.0
24.0, 24.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30 p26 p32

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
868.0, 604.0
32.0, 32.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
1014.0, 882.0
24.0, 24.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
974.0, 710.0
28.0, 28.0

ASK1

--

MO000000079

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000079

--

Go back
434.0, 566.0
28.0, 28.0

Rac1

--

MO000000166

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m146

10

false

infinite

0

unit false false false
TRANSPATHMO000000166

--

Go back
1119.0, 811.0
26.0, 26.0

RelA-p65

--

MO000000193

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m166

10

false

infinite

0

unit false false false
TRANSPATHMO000000193

--

Go back
579.0, 291.0
34.0, 34.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
753.0, 393.0
38.0, 38.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
782.0, 734.0
28.0, 28.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
827.0, 367.0
26.0, 26.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
626.0, 484.0
38.0, 38.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
881.0, 49.0
30.0, 30.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
661.0, 865.0
30.0, 30.0

MKK3

--

MO000016966

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m1875

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
1506.0, 1202.0
36.0, 36.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3 p8 p9 p10

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
1086.0, 406.0
28.0, 28.0

PI3K family

--

MO000017608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p5 p6 p7 p17 p21 p22

true true true true

csml-variable:Double

m2387

10

false

infinite

0

unit false false false
TRANSPATHMO000017608

--

Go back
1471.0, 567.0
34.0, 34.0

RANKL

--

MO000018743

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8

true true true true

csml-variable:Double

m3373

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000018743

--

Go back
414.0, 886.0
28.0, 28.0

MKK6

--

MO000019005

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m3613

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
973.0, 221.0
30.0, 30.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
337.0, 349.0
30.0, 30.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
651.0, 303.0
26.0, 26.0

Tollip

--

MO000019406

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m3973

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000019406

--

Go back
872.0, 1164.0
24.0, 24.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
309.2799548583088, 195.9213678790802
1110.2160357146968, 1794.4804119478729

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
319.97680906061726, 223.34917005147813
1076.1393161571723, 1685.157138954838

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1102.0, 634.0
28.0, 28.0

PI3K family

--

e11

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4 p5 p6 p7 p17 p21

p29 p31 p33 p34 p35

true true true true

csml-variable:Double

m11

10

false

infinite

0

unit false false false
TRANSPATHMO000017608

--

Go back
1122.0, 83.0
60.0, 34.0

peptidoglycan

--

e12

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1522.0, 423.9674868189807
36.20386643233744, 23.53251318101934

CD40L

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5 p9

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1481.0, 249.7589546298753
54.18944016980632, 11.7410453701247

CpG ODN

--

e14

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p6 p10

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
826.5, 221.59699027344465
26.08882363736466, 36.40300972655534

LPS:TLR4:MyD88

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p12 p22

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
759.0, 218.5
25.499999999999996, 42.5

LPS:TLR4:MyD88:IRAK

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p13

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
687.0, 217.58823529411768
26.647058823529417, 44.411764705882355

LPS:TLR4:MyD88:IRAK{p}

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p14

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
613.0, 225.82352941176464
21.70588235294118, 36.1764705882353

LPS:TLR4:MyD88:IRAK{p}:Tollip

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p15

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
508.0, 224.4411764705883
23.73529411764706, 39.55882352941178

LPS:TLR4:MyD88:IRAK{p}:Tollip:TRAF6

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p16

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
309.2799548583088, 195.9213678790802
1110.2160357146968, 1794.4804119478729

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
697.0, 617.0
38.0, 38.0

TAK1{active}

--

e20

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

p17 p18 p24

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
790.0, 878.0
28.0, 28.0

IKK{active}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

p23 p33

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
62.0, 377.62126537785593
44.42882249560633, 28.87873462214412

TLR2 ligand

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p19

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
333.5, 426.4698531023897
21.973909230431925, 42.53014689761017

TLR2 ligand: TLR2

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p20

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
502.0, 650.0
28.0, 28.0

Rac1{active}

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

p21

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000166

--

Go back
1032.0, 219.67647058823525
24.794117647058822, 41.32352941176471

LPS:TLR4:MYD88:PI3K

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1024.0, 1008.0
24.0, 24.0

NF-kappaB{active}

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23 p34

p35

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
519.0, 779.4682028577179
42.21372509559267, 26.03179714228215

MAP3K

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p24

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
482.0, 841.1466089756489
36.24874220165023, 22.353391024350977

MAP3K{active}

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

p24

p25 p28

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
661.0, 1017.0
30.0, 30.0

MKK3{active}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

p30

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
331.48427557260277, 220.63872892519402
1065.8073942861079, 1745.0456898556456

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
536.0, 1200.0
24.0, 24.0

p38{active}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30 p26 p32

--

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
446.0, 1018.0
28.0, 28.0

MKK6{active}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

p26

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
872.0, 732.0
32.0, 32.0

AKT{active}

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

p27

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
954.0, 829.4390243902438
36.95121951219513, 29.560975609756095

ASK1{p}

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

p27

p25 p28 p32

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
822.0, 1086.0
28.0, 28.0

MEKK3

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000009093

--

Go back
1170.0, 953.9268292682926
36.34146341463415, 29.073170731707318

RelA-p65

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

p31

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
835.0, 1003.0939226519336
24.215469613259668, 26.9060773480663

IkappaB-alpha:NF-kappaB

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
975.0, 1037.1602209944751
25.955801104972377, 28.83977900552486

IkappaB-alpha{p}:NF-kappaB

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
836.0, 1316.0
24.0, 24.0

NF-kappaB{active}

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

p36 p37

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
843.0, 1522.840830449827
49.048442906574394, 26.15916955017301

IL-12p40

--

e39

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p36

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
372.56226889404667, 263.8941107558934
983.6514076432215, 1658.5349261942463

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
954.0, 1508.0
60.0, 32.0

IL-12p35

--

e40

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p37

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
917.5, 220.9033106774831
20.19995614996711, 39.096689322516994

LPS:TLR4

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p2 p3 p11

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
544.2866002120593, 1230.7960595113273
603.7564749712761, 609.5103527707753

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
609.4967967638918, 1245.2405687833166
353.03451236681724, 590.7369332809153

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
552.1567963476252, 1238.9312079569327
588.0160827001447, 593.2400558795632

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
553.2811100812778, 1240.1827692562576
585.7674552328397, 590.7369332809153

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
544.2866002120593, 1230.7960595113273
603.7564749712761, 609.5103527707753

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
544.2866002120593, 1230.7960595113273
603.7564749712761, 609.5103527707753

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
553.2811100812778, 1240.1827692562576
585.7674552328397, 590.7369332809153

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
985.0175838037542, 1481.1083193761222
37.71938721379395, 38.010543927352536

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
886.0779752423531, 1656.3269012814794
106.80980469696685, 107.6342717418618

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
544.2866002120593, 1230.7960595113273
603.7564749712761, 609.5103527707753

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
914.0, 1336.5536332179931
43.96193771626297, 23.446366782006923

IL-12

--

e6

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p2

p3 p8 p9 p10

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
686.5886042589324, 1501.6574238571538
19.12008043538759, 10.24787720644234

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
685.9501306522473, 1471.095828981531
65.44354468523198, 131.13056405935882

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
713.404495739711, 1556.3840007274566
10.215577706963018, 11.37175623278991

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
323.8665742250932, 203.1424989161804
1088.776044706119, 1717.3748564024186

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
327.7563393895691, 233.45250561912724
1044.4758332919132, 1688.2222588225413

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
338.1290464948381, 263.762512322074
1039.7072281820178, 1666.0816469283054

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
938.0, 122.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000019394

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 12860525, 7612223, 10973276 Stimulation through TLRs by PAMPs, such as lipopolysaccharide (LPS) (endotoxin), triggers production of various cytokines, including interleukin-12 (IL-12), which is a crucial inducer of Th1 responses.

Go back
1193.0, 1360.5
22.5, 22.5

p10

p10

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e6 e14

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c29 : 1
stoichiometry:c28 : 1

m6*m14*0.1

nodelay

--

true

0

false

PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631 PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-¦ÊB ligand), all of which induce IL-12 production.

Go back
828.0, 308.0
23.0, 23.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e5

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m1572*m5*0.1

nodelay

--

true

0

false

PMID: 12860525, 16924467, 12524386 PI3K is activated after triggering of many TLR members, suggesting the presence of ¡Æshared¡Ç signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ¡Æshared¡Ç signaling pathway(s).

Go back
760.0, 316.0
23.0, 23.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m184*m15*0.1

nodelay

--

true

0

false

PMID: 12860525, 16924467, 12524386 PI3K is activated after triggering of many TLR members, suggesting the presence of ¡Æshared¡Ç signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ¡Æshared¡Ç signaling pathway(s).

Go back
689.0, 325.0
21.0, 21.0

p13

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 12860525, 16924467, 12524386 PI3K is activated after triggering of many TLR members, suggesting the presence of ¡Æshared¡Ç signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ¡Æshared¡Ç signaling pathway(s).

Go back
653.0, 125.0
21.0, 21.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000019406

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m17*m3973*0.1

nodelay

--

true

0

false

PMID: 12860525, 16924467, 12524386 PI3K is activated after triggering of many TLR members, suggesting the presence of ¡Æshared¡Ç signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ¡Æshared¡Ç signaling pathway(s).

Go back
563.0, 123.0
25.0, 25.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 MO000000212

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m18*m183*0.1

nodelay

--

true

0

false

PMID: 12860525, 16924467, 12524386 PI3K is activated after triggering of many TLR members, suggesting the presence of ¡Æshared¡Ç signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ¡Æshared¡Ç signaling pathway(s).

Go back
706.0, 546.0
19.0, 19.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016574 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c46 : 1
stoichiometry:c45 : 1

m1573*m19*0.1

nodelay

--

true

0

false

PMID: 12860525, 11129660, 11460167 In TLR4 signaling, TAK1 (transforming growth factor ¦Â-activated kinase 1) and TRAF6 pathways are operative in PI3K activation downstream of TLR4.

Go back
1025.0, 497.0
21.0, 21.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017608 e20

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c49 : 1
stoichiometry:c48 : 1

m2387*m20*0.1

nodelay

--

true

0

false

PMID: 12860525, 11129660, 11460167 In TLR4 signaling, TAK1 (transforming growth factor ¦Â-activated kinase 1) and TRAF6 pathways are operative in PI3K activation downstream of TLR4.

Go back
744.0, 800.0
23.0, 23.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c52 : 1
stoichiometry:c51 : 1

m207*m20*0.1

nodelay

--

true

0

false

PMID: 12860525 confirmed pathway from fig.1

Go back
238.0, 322.0
19.0, 19.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000019397

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m22*m3964*0.1

nodelay

--

true

0

false

PMID: 12860525 TLR2 binds TLR2 ligand

Go back
924.0, 1284.0
23.0, 23.0

p2

p2

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c4 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 12860525, 7612223, 10973276 Stimulation through TLRs by PAMPs, such as lipopolysaccharide (LPS) (endotoxin), triggers production of various cytokines, including interleukin-12 (IL-12), which is a crucial inducer of Th1 responses.

Go back
506.0, 570.0
19.0, 19.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000166 e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c58 : 1
stoichiometry:c57 : 1

m146*m23*0.1

nodelay

--

true

0

false

PMID: 12860525, 11101877 activation of PI3K downstream of TLR2 is mediated in a Rac1-dependent manner.

Go back
1033.0, 449.0
21.0, 21.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017608 e24

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c61 : 1
stoichiometry:c60 : 1

m2387*m24*0.1

nodelay

--

true

0

false

PMID: 12860525, 11101877 activation of PI3K downstream of TLR2 is mediated in a Rac1-dependent manner.

Go back
885.0, 377.0
21.0, 21.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000017608

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m15*m2387*0.1

nodelay

--

true

0

false

PMID: 12860525, 12616480 interaction of PI3K with MyD88 in response to LPS has been reported, demonstrating the importance of such ¡Æshared¡Ç signaling in the PI3K pathway

Go back
1046.0, 946.0
19.0, 19.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e21

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c67 : 1
stoichiometry:c66 : 1

m26*m21*0.1

nodelay

--

true

0

false

PMID: 12860525 confirmed pathway from fig.1

Go back
598.0, 842.0
19.0, 19.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e27 e20

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c70 : 1
stoichiometry:c69 : 1

m28*m20*0.1

nodelay

--

true

0

false

--

Go back
704.0, 968.0
23.0, 23.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016966 e28 e33

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c73 : 1
stoichiometry:c89 : 1
stoichiometry:c72 : 1

m1875*m29*0.1

nodelay

--

true

0

false

PMID: 12860525 confirmed pathway from fig.1 PMID: 12860525, 11154276 Protein kinase B (PKB)-mediated phosphorylation of apoptosis signal-regulating kinase 1 (ASK1), one of the MAPK kinase kinases (MAPKK-Ks), blocks ASK1 kinase activity, leading to suppression of MAPK kinase 3 (MKK3) or MKK6, upstream regulators of p38

Go back
501.0, 1141.0
21.0, 21.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 e31

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c82 : 1
stoichiometry:c78 : 1

m31*m33*0.1

nodelay

--

true

0

false

PMID: 12860525 confirmed pathway from fig.1

Go back
978.0, 770.0
19.0, 19.0

p27

p27

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000079 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c88 : 1
stoichiometry:c87 : 1

m71*m34*0.1

nodelay

--

true

0

false

PMID: 12860525, 11154276 Protein kinase B (PKB)-mediated phosphorylation of apoptosis signal-regulating kinase 1 (ASK1), one of the MAPK kinase kinases (MAPKK-Ks), blocks ASK1 kinase activity, leading to suppression of MAPK kinase 3 (MKK3) or MKK6, upstream regulators of p38

Go back
417.0, 957.0
21.0, 21.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019005 e28 e33

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c90 : 1
stoichiometry:c80 : 1

m3613*m29*0.1

nodelay

--

true

0

false

PMID: 12860525, 11154276 Protein kinase B (PKB)-mediated phosphorylation of apoptosis signal-regulating kinase 1 (ASK1), one of the MAPK kinase kinases (MAPKK-Ks), blocks ASK1 kinase activity, leading to suppression of MAPK kinase 3 (MKK3) or MKK6, upstream regulators of p38

Go back
849.0, 673.0
21.0, 21.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000048 e11

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c84 : 1

m45*m11*0.1

nodelay

--

true

0

false

PMID: 12860525, 9192891 activation of PKB is positively regulated by PI3K.

Go back
1196.0, 1208.0
23.0, 23.0

p3

p3

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e6 e5

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c8 : 1
stoichiometry:c6 : 1

m6*m5*0.1

nodelay

--

true

0

false

PMID: 12860525, 7612223, 10973276 Stimulation through TLRs by PAMPs, such as lipopolysaccharide (LPS) (endotoxin), triggers production of various cytokines, including interleukin-12 (IL-12), which is a crucial inducer of Th1 responses.

Go back
567.0, 1139.0
25.0, 25.0

p30

p30

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c76 : 1
stoichiometry:c75 : 1

m31*m30*0.1

nodelay

--

true

0

false

PMID: 12860525 confirmed pathway from fig.1

Go back
1178.0, 886.0
19.0, 19.0

p31

p31

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000193 e11

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c97 : 1
stoichiometry:c93 : 1

m166*m11*0.1

nodelay

--

true

0

false

PMID: 12860525, 11101877, 10373529 NF-¦ÊB transactivation by the PI3K cascade in TLR2-mediated signaling is independent of I¦ÊB¦Á (inhibitor of NF-¦ÊB¦Á) degradation and triggered by PI3K-pathway-mediated p65 phosphorylation.

Go back
632.0, 1132.0
23.0, 23.0

p32

p32

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 e34 e33

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c96 : 1
stoichiometry:c91 : 1
stoichiometry:c95 : 1

m31*m36*0.1

nodelay

--

true

0

false

PMID: 12860525, 11387313 PKB blocks kinase activity of MEKK3, another MAPKK-K upstream of p38.

Go back
901.0, 1041.0
21.0, 21.0

p33

p33

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e36 e21 e11

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c100 : 1
stoichiometry:c106 : 1
stoichiometry:c99 : 1

m38*m21*0.1

nodelay

--

true

0

false

PMID: 12860525, 12052830 inhibition of PI3K augments the phosphorylation and degradation of I¦ÊB¦Á, resulting in nuclear localization of NF-¦ÊB in monocytes.

Go back
984.0, 1120.0
23.0, 23.0

p34

p34

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e37 e11

MO000019479 e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c107 : 1
stoichiometry:c101 : 1
stoichiometry:c103 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 12860525, 12052830 inhibition of PI3K augments the phosphorylation and degradation of I¦ÊB¦Á, resulting in nuclear localization of NF-¦ÊB in monocytes.

Go back
1030.0, 1182.0
19.0, 19.0

p35

p35

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e26 e11

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c108 : 1
stoichiometry:c105 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 12860525, 12052830 inhibition of PI3K augments the phosphorylation and degradation of I¦ÊB¦Á, resulting in nuclear localization of NF-¦ÊB in monocytes.

Go back
856.0, 1428.0
23.0, 23.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c109 : 1

m40*0.1

nodelay

--

true

0

false

--

Go back
972.0, 1408.0
23.0, 23.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e38

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c110 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 12860525, 7612223, 10973276 NF-¦ÊB activation is required for the transcription of both IL-12 p35 and p40

Go back
1106.0, 530.5
19.5, 19.5

p4

p4

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017608 e12

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c11 : 1
stoichiometry:c10 : 1

m2387*m12*0.1

nodelay

--

true

0

false

PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631 PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-¦ÊB ligand), all of which induce IL-12 production.

Go back
1166.0, 578.0
19.0, 19.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e13 MO000017608

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m13*m2387*0.1

nodelay

--

true

0

false

PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631 PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-¦ÊB ligand), all of which induce IL-12 production.

Go back
1074.0, 530.5
19.5, 19.5

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017608 e14

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c17 : 1
stoichiometry:c16 : 1

m2387*m14*0.1

nodelay

--

true

0

false

PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631 PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-¦ÊB ligand), all of which induce IL-12 production.

Go back
1185.0, 517.0
21.0, 21.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017608 MO000018743

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c20 : 1
stoichiometry:c19 : 1

m2387*m3373*0.1

nodelay

--

true

0

false

PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631 PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-¦ÊB ligand), all of which induce IL-12 production.

Go back
1236.0, 1276.0
23.0, 23.0

p8

p8

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e6 MO000018743

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c23 : 1
stoichiometry:c22 : 1

m6*m3373*0.1

nodelay

--

true

0

false

PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631 PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-¦ÊB ligand), all of which induce IL-12 production.

Go back
1207.0, 1135.0
17.0, 17.0

p9

p9

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e6 e13

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c26 : 1
stoichiometry:c25 : 1

m6*m13*0.1

nodelay

--

true

0

false

--

Go back
907.0, 79.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1116.0, 550.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
813.0, 906.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
903.4623850752448, 1137.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
989.0, 1066.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.0, 1039.5183473879074

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1036.0, 1032.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
866.5357429061181, 1199.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
919.8001553201204, 662.0

c106

c106

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
999.9661537370597, 662.0

c107

c107

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1041.5560855737954, 662.0

c108

c108

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
868.0, 1451.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1117.6548003536773, 117.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
984.0, 1431.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
850.0, 1340.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
860.0, 1336.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1192.3878542440334, 444.0

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1106.0, 434.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1135.6568542494924, 597.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1086.0626638893168, 434.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1087.0, 550.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1100.6463112182357, 262.0

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1112.0, 434.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1129.437601569802, 538.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
953.8905685420692, 148.45953172146886

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1213.855840053257, 531.5118786517589

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
958.0, 1291.5254450313403

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1259.0, 1225.9180813318717

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1254.5802492992138, 601.0

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
952.0, 1155.7144114488897

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1224.0, 1146.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1223.3343310936464, 448.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
958.0, 1350.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1216.0, 1232.4375346821403

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1209.106721800948, 262.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
932.4743082804015, 141.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
840.0, 339.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.9596035747526, 250.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.0, 266.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
772.0, 347.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
785.9189245967844, 257.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
772.0, 269.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
712.8, 257.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
700.0, 270.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
669.6240935117632, 153.5573893138783

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
664.0, 154.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
936.0, 1307.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
633.7263945889712, 146.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
584.2751338252662, 155.29886966773606

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
577.944398901614, 155.94406134887126

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
533.7259714626609, 148.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
664.0, 517.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
716.0, 565.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.0, 263.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1048.7175610316242, 434.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1042.0, 518.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
735.0, 514.9711254108329

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
958.0, 1229.406376290639

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
767.2719439311038, 762.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
762.0, 823.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 655.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
106.0, 338.7339445046936

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
264.6626102817692, 337.2987830845308

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
256.0, 341.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
462.0, 580.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.0, 589.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
355.0, 457.0

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1060.4961229707417, 430.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1219.0, 1220.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1048.0, 470.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
530.0, 466.89169666546536

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
847.0, 258.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
913.9049317516391, 391.22965605025496

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
906.0, 257.65685424949237

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1032.0, 906.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1042.3151160102107, 965.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
818.0, 896.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
555.0, 806.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
526.0, 852.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
928.0, 260.0

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
616.5623785035427, 655.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
682.0, 895.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
691.8776860867976, 991.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
518.0, 863.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
554.0, 1096.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
557.734068956465, 1164.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
595.014069158532, 1047.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.7647058823529, 1096.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
518.0, 1162.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.0, 914.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
934.0, 260.0

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
433.0, 978.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
439.20085861637284, 863.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
466.0, 1046.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
866.8311367793272, 636.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
864.0, 694.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
877.9202772896064, 650.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
988.0, 738.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.9402850002907, 789.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
904.0, 753.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
730.5362878125189, 854.0

c89

c89

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1102.0, 434.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
441.89934020347215, 848.0

c90

c90

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
657.9530922221818, 859.0

c91

c91

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1142.0, 837.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1188.0, 905.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
560.0, 1091.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.5281958488132, 1152.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
662.8006037422365, 1103.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1120.0, 662.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
859.0, 1024.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
922.0, 1052.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back