1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/1315450.csml convertedTime:2009.07.01.10:42

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The role of macrophages in the hypothalamic-pituitary-adrenal activation inresponse to endotoxin (LPS).
Authors Derijk RH, van Rooijen N, Berkenbosch F.
Affiliation Department of Pharmacology, Free University, Amsterdam.
Abstract
PMID 1315450
Model Abstract

Entity

G010262:IL-6 MO000000204:TNF MO000000214:IL-1 MO000007384:IL-6 MO000016882:LPS e1: e10: e11:ACTH e12:TNF e13:IL-1 e14:TNFR e15:TNF:TNFR e16:IL-1R e17:IL-1:IL-1R e18:IL-6:IL-6R e19:IL-6R e2: e20:complement e21:C3a e22:C5a e23:histamines e3: e4: e5:corticosterone e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:ACTH e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p3 p4 p5 p6 p7 p8 p9
Model Detail
613.0, 1069.0
38.0, 38.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
1082.0, 914.0
44.0, 44.0

TNF

--

MO000000204

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4

p9

true true true true

csml-variable:Double

m175

10

false

infinite

0

unit false false false
TRANSPATHMO000000204

--

Go back
1194.0, 985.5
36.5, 36.5

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
1119.0, 1067.0
50.0, 50.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
1116.0, 488.0
32.0, 32.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p3 p4 p5 p6 p20

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
168.75, 99.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
177.0, 119.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1071.0, 840.4199999999998
41.44, 31.08

ACTH

--

e11

cso30:c:Protein

cso30:i:CC_Extracellular

--

p2 p13 p14 p16

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
624.0, 920.7716262975779
56.67820069204152, 30.22837370242215

TNF

--

e12

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p3

p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
646.0, 992.0
60.0, 32.0

IL-1

--

e13

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p5

p6

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
976.5, 942.0
39.0, 60.0

TNFR

--

e14

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p9

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
976.5, 1142.0
31.0, 60.0

TNF:TNFR

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
964.5, 1226.0
39.0, 60.0

IL-1R

--

e16

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p10

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
824.5, 1286.0
31.0, 60.0

IL-1:IL-1R

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
672.5, 1278.0
31.0, 60.0

IL-6:IL-6R

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
900.5, 1282.0
39.0, 60.0

IL-6R

--

e19

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p15

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
168.75, 99.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
434.0, 523.9379150734553
52.80338096196418, 32.56208492654457

complement

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
382.5, 670.1078687864762
27.066814248339707, 43.892131213523854

C3a

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
484.0, 713.510757717493
23.17867165575304, 53.48924228250701

C5a

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
70.0, 743.0
60.0, 34.0

histamines

--

e23

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p21 p22

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
185.87518862352903, 117.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
217.55678757705792, 147.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1090.0, 671.0
60.0, 34.0

corticosterone

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p1 p17 p18 p19

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
350.0, 817.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
400.29367619468036, 827.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
356.06992643728904, 822.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
356.93705878547314, 823.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
350.0, 817.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
350.0, 817.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
356.93705878547314, 823.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
689.9158804881849, 990.4264696368292
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
613.6082338479803, 1111.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
350.0, 817.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
510.0, 836.0
60.0, 32.0

ACTH

--

e6

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p2 p13 p14 p16

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
459.7511016961721, 1004.6637213250546
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
459.25867587120234, 983.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
480.43298634490145, 1042.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
180.0, 105.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
183.0, 126.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
191.0, 147.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
712.0, 676.0
23.0, 23.0

p1

p1

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 1315450, 2361453, 1647300 Our time-course studies show that plasma corticosterone levels are already maximally elevated 1 hour after endotoxin administration.

Go back
1200.0, 1244.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m16*m185*0.1

nodelay

--

true

0

false

PMID: 1315450, 3543052 The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF) which in turn induce other cytokines like interleukin 6.

Go back
539.0, 1119.0
25.0, 25.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c27 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 1315450, 3543052 The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF) which in turn induce other cytokines like interleukin 6.

Go back
857.0, 1125.0
21.0, 21.0

p12

p12

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c28 : 1

m93248*m17*0.1

nodelay

--

true

0

false

PMID: 1315450, 3543052 The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF) which in turn induce other cytokines like interleukin 6.

Go back
824.0, 880.0
23.0, 23.0

p13

p13

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c32 : 1

m6*m17*0.1

nodelay

--

true

0

false

PMID: 1315450, 2361453, 2845968, 2542010 Injections of recombinant preparations of these 3 cytokines can induce the release of ACTH and corcorticosterone, by an action involving the release of CRF from the hypothalamus.

Go back
871.0, 815.0
25.0, 25.0

p14

p14

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c35 : 1

m6*m15*0.1

nodelay

--

true

0

false

PMID: 1315450, 2361453, 2845968, 2542010 Injections of recombinant preparations of these 3 cytokines can induce the release of ACTH and corcorticosterone, by an action involving the release of CRF from the hypothalamus.

Go back
1132.0, 1188.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m871*m19*0.1

nodelay

--

true

0

false

PMID: 1315450, 2361453, 2845968, 2542010 Injections of recombinant preparations of these 3 cytokines can induce the release of ACTH and corcorticosterone, by an action involving the release of CRF from the hypothalamus.

Go back
915.0, 891.0
25.0, 25.0

p16

p16

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c41 : 1

m6*m18*0.1

nodelay

--

true

0

false

PMID: 1315450, 2361453, 2845968, 2542010 Injections of recombinant preparations of these 3 cytokines can induce the release of ACTH and corcorticosterone, by an action involving the release of CRF from the hypothalamus.

Go back
648.0, 716.0
23.0, 23.0

p17

p17

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c44 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 1315450, 2361453, 2845968, 2542010 Injections of recombinant preparations of these 3 cytokines can induce the release of ACTH and corcorticosterone, by an action involving the release of CRF from the hypothalamus.

Go back
769.0, 612.0
23.0, 23.0

p18

p18

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c46 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 1315450, 2361453, 2845968, 2542010 Injections of recombinant preparations of these 3 cytokines can induce the release of ACTH and corcorticosterone, by an action involving the release of CRF from the hypothalamus.

Go back
672.0, 636.0
23.0, 23.0

p19

p19

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c48 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 1315450, 2361453, 2845968, 2542010 Injections of recombinant preparations of these 3 cytokines can induce the release of ACTH and corcorticosterone, by an action involving the release of CRF from the hypothalamus.

Go back
775.0, 843.0
25.0, 25.0

p2

p2

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c3 : 1

m6*m155666*0.1

nodelay

--

true

0

false

PMID: 1315450, 2555127, 4719686, 3330674 endotoxin administration elevates plasma ACTH and glucocorticoid levels in a variety of species including man.

Go back
449.0, 617.0
21.0, 21.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c53 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m20*m155666*0.1

nodelay

--

true

0

false

PMID: 1315450 endotoxin induces the activation of the complement system resulting in the generation of C3a and CSa, which in turn can degranulate mast cells resulting in the release of vasoactive substances, such as histamine.

Go back
289.0, 685.0
30.0, 30.0

p21

p21

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c54 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 1315450 endotoxin induces the activation of the complement system resulting in the generation of C3a and CSa, which in turn can degranulate mast cells resulting in the release of vasoactive substances, such as histamine.

Go back
361.0, 773.0
30.0, 30.0

p22

p22

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c55 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 1315450 endotoxin induces the activation of the complement system resulting in the generation of C3a and CSa, which in turn can degranulate mast cells resulting in the release of vasoactive substances, such as histamine.

Go back
514.0, 922.0
27.0, 27.0

p3

p3

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c7 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 1315450, 3543052 The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF) which in turn induce other cytokines like interleukin 6.

Go back
858.0, 922.0
27.0, 27.0

p4

p4

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c10 : 1
stoichiometry:c6 : 1

m12*m155666*0.1

nodelay

--

true

0

false

PMID: 1315450, 3543052 The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF) which in turn induce other cytokines like interleukin 6.

Go back
547.0, 995.0
25.0, 25.0

p5

p5

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c11 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 1315450, 3543052 The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF) which in turn induce other cytokines like interleukin 6.

Go back
887.0, 991.0
25.0, 25.0

p6

p6

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c12 : 1

m13*m155666*0.1

nodelay

--

true

0

false

PMID: 1315450, 3543052 The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF) which in turn induce other cytokines like interleukin 6.

Go back
537.0, 1077.0
21.0, 21.0

p7

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c17 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 1315450, 3543052 The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF) which in turn induce other cytokines like interleukin 6.

Go back
860.0, 1080.0
23.0, 23.0

p8

p8

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c22 : 1
stoichiometry:c16 : 1

m93248*m15*0.1

nodelay

--

true

0

false

PMID: 1315450, 3543052 The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF) which in turn induce other cytokines like interleukin 6.

Go back
1235.0, 963.0
17.0, 17.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m175*m14*0.1

nodelay

--

true

0

false

PMID: 1315450, 3543052 The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF) which in turn induce other cytokines like interleukin 6.

Go back
742.2914278651342, 511.0

c1

c1

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
884.1259907909819, 520.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.0, 1008.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.0, 1004.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.0, 1004.1325784755602

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
909.3729625518243, 520.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
578.0041752305708, 518.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
883.0, 1092.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
558.0, 1088.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.0, 1088.0

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1126.0, 942.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
735.0, 688.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1016.0, 972.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.2550072479642, 979.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
889.6455059195068, 1103.4539029034993

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
565.8614866574045, 1091.4822373411334

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1004.0, 1256.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1212.0, 1022.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
863.8960581594441, 1258.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
564.0, 1101.860838029177

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
878.0, 1097.2460167530355

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.0, 1092.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
800.0, 856.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
845.0, 1153.9114908229465

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
570.7503566593692, 1144.2933302891008

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
847.0, 860.0966904401805

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
570.0, 856.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
836.0835463575821, 910.9995637384882

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
896.0, 830.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
570.0, 829.5567861027923

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
890.4005839249475, 847.6313299508856

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1144.0, 1117.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.0, 1209.5777087639997

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
570.0, 853.0

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
711.7861427833735, 1203.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.0, 864.2287366070817

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
570.0, 856.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
704.0, 922.8814158712712

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
671.0, 691.6848277668624

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
672.8, 745.4

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
792.0, 626.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
782.673483938924, 642.9716008043562

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
695.0, 649.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
684.0516952049992, 666.9998329736177

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
805.5857072050433, 520.0

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
460.0, 556.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
415.65685424949237, 638.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
463.0, 638.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
477.8676255087126, 507.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
137.67184361354572, 704.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
137.96063799474356, 763.7926176358403

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
326.9650738084743, 693.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
398.4333130260619, 745.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
885.0, 936.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.0, 936.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.0, 936.0

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
547.502983228668, 515.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back