Original Literature | Model OverView |
---|---|
Publication
Title
Protein kinase C epsilon: a new target to control inflammation andimmune-mediated disorders.
Affiliation
Laboratory of Experimental Immunology, Universite Libre de Bruxelles, B-1070,Brussels, Belgium
Abstract
Recent advances in understanding the molecular basis for mammalian host immuneresponses to microbial invasion suggest that the first line of defense againstmicrobes is the recognition of pathogen-associated molecular patterns by a setof germline-encoded receptors: the Toll-like receptors (TLRs). TLRs have beenidentified as being part of a large family of pathogen-recognition receptorsthat play a decisive role in the induction of both innate and adaptive immunity.Indeed, activation of T lymphocytes depends on their interaction with dendriticcells previously stimulated by TLR agonists such as bacterial lipopolysaccharide(LPS), a TLR-4 ligand. A novel PKC epsilon (epsilon) was recently found to be acritical component of TLR-4 signaling pathway and thereby to play a key role inmacrophage and dendritic cell (DC) activation in response to LPS. Thus,controlling the kinase activity of PKC epsilon might represent an efficientstrategy to prevent or treat certain inflammatory disorders of microbial origin.
PMID
14643884
|
Entity
Process
csml-variable:Double
m88393
10
infinite
0
--
csml-variable:Double
m118431
10
infinite
0
--
c-Rel
--
MO000000192
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m165
10
infinite
0
TRANSPATH | MO000000192 |
--
IL-1RI
--
MO000007336
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m310329
10
infinite
0
DIP | 93 |
InterPro | IPR004076 |
PDB | 1IRA |
Proteome | HumanPSD/IL1R1 |
UniProt | P14778 |
--
MyD88
--
MO000016573
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m1572
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000016573 |
--
PKCepsilon{activate}
--
MO000016645
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m1629
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000016645 |
--
IFNbeta
--
MO000016660
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m1636
10
infinite
0
InterPro | IPR000471 |
TRANSPATH | MO000016660 |
--
IFNRIalpha/beta
--
MO000016669
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
csml-variable:Double
m1642
10
infinite
0
--
MAPK
--
MO000016894
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
csml-variable:Double
m1812
10
infinite
0
TRANSPATH | MO000016894 |
--
CD14
--
MO000018132
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m2828
10
infinite
0
InterPro | IPR001611 |
TRANSPATH | MO000018132 |
--
TLR4
--
MO000019394
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m3961
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000019394 |
--
TLRs
--
MO000019395
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m3962
10
infinite
0
TRANSPATH | MO000019395 |
--
TLR2
--
MO000019397
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m3964
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000019397 |
--
NF-kappaB
--
MO000019669
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
csml-variable:Double
m330830
10
infinite
0
--
MD-2
--
MO000022131
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m6438
10
infinite
0
InterPro | IPR003172 |
TRANSPATH | MO000022131 |
--
TIRAP
--
MO000022528
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m6810
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000022528 |
--
PGN:CD14:TLR2
--
MO000042039
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m128944
10
infinite
0
--
TLR2:CD14
--
MO000096323
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m69486
10
infinite
0
--
csml-variable:Double
m309848
10
infinite
0
--
LPS
--
e1
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
csml-variable:Double
m1
0
infinite
0
--
csml-variable:Double
m10
0
infinite
0
--
IFNRIalpha/beta
--
e11
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m11
10
infinite
0
--
TLR-4:LPS
--
e12
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m12
0
infinite
0
--
csml-variable:Double
m13
10
infinite
0
--
csml-variable:Double
m15
0
infinite
0
--
csml-variable:Double
m16
0
infinite
0
--
csml-variable:Double
m17
0
infinite
0
--
--
e18
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m18
0
infinite
0
--
--
e19
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m19
0
infinite
0
--
IRF-3{activate}
--
e2
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m2
10
infinite
0
InterPro | IPR008984 |
TRANSPATH | MO000007694 |
--
--
e20
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m20
0
infinite
0
--
--
e21
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m21
0
infinite
0
--
--
e22
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m22
0
infinite
0
--
--
e23
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m23
0
infinite
0
--
--
e24
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m24
0
infinite
0
--
--
e25
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m25
0
infinite
0
--
csml-variable:Double
m26
0
infinite
0
--
--
e27
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m27
0
infinite
0
--
TLRs:LPS
--
e3
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m3
0
infinite
0
--
TLR4:MD2:CD14
--
e30
cso30:c:Complex
cso30:i:CC_PlasmaMembrane
--
csml-variable:Double
m30
0
infinite
0
--
PGN
--
e31
cso30:c:SmallMolecule
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m31
0
infinite
0
--
TLR4:MD2:CD14:LPS
--
e33
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m33
0
infinite
0
--
TLR2:CD14:TIRAP:MyD88
--
e36
cso30:c:Complex
cso30:i:CC_PlasmaMembrane
--
csml-variable:Double
m36
0
infinite
0
--
TLR4:MD2:CD14:TIRAP:MyD88
--
e37
cso30:c:Complex
cso30:i:CC_PlasmaMembrane
--
csml-variable:Double
m37
0
infinite
0
--
TLR2:CD14:TIRAP:MyD88:IRAK
--
e39
cso30:c:Complex
cso30:i:CC_PlasmaMembrane
--
csml-variable:Double
m39
0
infinite
0
--
double-stranded RNA (viruses)
--
e4
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m4
0
infinite
0
--
TLR4:MC2:CD14:TIRAP:MyD88:IRAK
--
e40
cso30:c:Complex
cso30:i:CC_PlasmaMembrane
--
csml-variable:Double
m40
0
infinite
0
--
IRAK{active}
--
e41
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m41
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000000213 |
--
csml-variable:Double
m42
0
infinite
0
--
csml-variable:Double
m43
0
infinite
0
--
TAB1:TAB2:TAK1:IRAK:TRAF-6
--
e47
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m47
0
infinite
0
--
mannan (fungi)
--
e5
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m5
0
infinite
0
--
csml-variable:Double
m51
0
infinite
0
--
csml-variable:Double
m52
0
infinite
0
--
csml-variable:Double
m53
0
infinite
0
--
NF-kappaB{active}
--
e54
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m54
10
infinite
0
--
csml-variable:Double
m57
0
infinite
0
--
csml-variable:Double
m58
0
infinite
0
--
mannan:TLRs
--
e6
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m6
0
infinite
0
--
double-stranded RNA(viruses):TLRs
--
e7
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
csml-variable:Double
m7
0
infinite
0
--
p1
p1
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c14 : 1
stoichiometry:c3 : 1
m1*m3962*0.1
nodelay
--
0
PMID: 14643884 The TLRs recognize molecular patterns that are characteristic of particular classes of microorganism, such as lipopolysaccharide (LPS; Gram-negative bacteria), double-stranded RNA (viruses) and mannan (fungi).
p1
p10
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c26 : 1
stoichiometry:c2 : 1
stoichiometry:c27 : 1
m6438*m2828*m3961*0.1
nodelay
--
0
TLR-4 and TLR-2 require the co-receptor, CD14 and a secreted protein, MD-2 to transmit LPS or PGN signals.
p38
p100
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
1.0*0.1
nodelay
--
0
--
p38
p101
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p102
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p103
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p39
p104
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p105
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p106
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p107
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p108
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p109
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m31*m69486*0.1
nodelay
--
0
TLR-4 and TLR-2 require the co-receptor, CD14 and a secreted protein, MD-2 to transmit LPS or PGN signals.
p39
p110
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p111
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p112
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p113
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p114
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p115
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p116
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p117
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p118
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p119
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c32 : 1
m1*m30*0.1
nodelay
--
0
TLR-4 and TLR-2 require the co-receptor, CD14 and a secreted protein, MD-2 to transmit LPS or PGN signals.
p39
p120
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p121
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p122
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p123
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p124
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p38
p125
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p39
p126
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p128
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p39
p129
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p13
p13
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c30 : 1
stoichiometry:c37 : 1
stoichiometry:c41 : 1
m69486*m1572*m6810*0.1
nodelay
--
0
TIRAP and MyD88 are recruited to both TLR-4 and TLR-2 by TIR domain interactions Signaling downstream from certain TLRs, such as TLR-2, appears to be completely dependent on MyD88 (Fig. 2) (Yamamoto et al., 2002).
p39
p130
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c113 : 1
stoichiometry:c47 : 1
m36*m41*0.1
nodelay
--
0
IRAK is recruited by its DD (grey region)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c46 : 1
stoichiometry:c50 : 1
m37*m41*0.1
nodelay
--
0
IRAK is recruited by its DD (grey region)
p13
p16
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c33 : 1
stoichiometry:c39 : 1
stoichiometry:c43 : 1
m30*m1572*m6810*0.1
nodelay
--
0
TIRAP and MyD88 are recruited to both TLR-4 and TLR-2 by TIR domain interactions
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c114 : 1
stoichiometry:c53 : 1
m183*m41*0.1
nodelay
--
0
IRAK associates with TRAF-6 in the cytoplasm.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1
m42*m43*0.1
nodelay
--
0
IRAK associates with TRAF-6 in the cytoplasm. Subsequently, tumor-necrosis factor receptor (TNFR)-associated factor 6 (TRAF-6) is activated, triggering the NF-_B and mitogen-activated protein kinase (MAPK) pathways, which leads to secretion of pro-inflammatory cytokines (O¡ÇNeill, 2002; Takeda, Kaisho, & Akira, 2003)
p19
p19
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c61 : 1
stoichiometry:c64 : 1
m47*m46*0.1
nodelay
--
0
TRAF-6 forms a complex with TAB1-TAB2-TAK1 upon which TAK1 mediates downstream NF-_B, p38, ERK and JNK activation.
p2
p2
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c40 : 1
stoichiometry:c5 : 1
m5*m3962*0.1
nodelay
--
0
PMID: 14643884 The TLRs recognize molecular patterns that are characteristic of particular classes of microorganism, such as lipopolysaccharide (LPS; Gram-negative bacteria), double-stranded RNA (viruses) and mannan (fungi).
p20
p20
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c86 : 1
stoichiometry:c62 : 1
m47*m8*0.1
nodelay
--
0
TRAF-6 forms a complex with TAB1-TAB2-TAK1 upon which TAK1 mediates downstream NF-_B, p38, ERK and JNK activation.
p21
p21
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c63 : 1
stoichiometry:c52 : 1
m47*m49*0.1
nodelay
--
0
TRAF-6 forms a complex with TAB1-TAB2-TAK1 upon which TAK1 mediates downstream NF-_B, p38, ERK and JNK activation.
p22
p22
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c90 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c66 : 1
m33*m128944*m54*m165*0.1
nodelay
--
0
TIRAP exclusively regulates phenotypic maturation of DC: increase of CD40, CD80 and CD86 surface expression. IL-12 p70 is produced only in response to TLR-4 signaling. whereas stimulation through TLR-2 with Staphylococcus aureus peptidoglycan (PGN) results only in the release of the IL-12 p40 (Fig. 2) (Re& Strominger, 2001; Nau, Schlesinger, Richmond, & Young, 2003) c-Rel and NF-_B1/p50 are essential for LPS-induced IL-12 production (Ouaaz, Arron, Zheng, Choi, & Beg, 2002)
p22
p23
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c89 : 1
stoichiometry:c67 : 1
m33*m128944*0.1
nodelay
--
0
TIRAP exclusively regulates phenotypic maturation of DC: increase of CD40, CD80 and CD86 surface expression. IL-12 p70 is produced only in response to TLR-4 signaling.
p22
p24
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c29 : 1
stoichiometry:c68 : 1
m33*m128944*0.1
nodelay
--
0
TIRAP exclusively regulates phenotypic maturation of DC: increase of CD40, CD80 and CD86 surface expression. IL-12 p70 is produced only in response to TLR-4 signaling.
p25
p25
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c75 : 1
stoichiometry:c77 : 1
m330830*m1629*0.1
nodelay
--
0
PMID: 14643884, 11937546 initiated upon LPS binding to TLR-4, predominantly leading to nuclear factor NF-kB and mitogen-activated protein (MAP) kinases activation. PKC isoforms actively participate in several TLR signaling pathways. PMID: 14643884, 11521059 Nevertheless, NF-kB and MAPKs can still be activated by TLR-4 but not TLR-2 in DCs derived from MyD88 ¡Ý/¡Ý mice, supporting the existence of an alternative, MyD88-independent pathway.
p25
p26
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c80 : 1
stoichiometry:c79 : 1
m1812*m12*0.1
nodelay
--
0
PMID: 14643884 initiated upon LPS binding to TLR-4, predominantly leading to nuclear factor (NF)-kB and mitogen-activated protein (MAP) kinases activation. PKC isoforms actively participate in several TLR signaling pathways. PMID: 14643884, 11521059 Nevertheless, NF-kB and MAPKs can still be activated by TLR-4 but not TLR-2 in DCs derived from MyD88 ¡Ý/¡Ý mice, supporting the existence of an alternative, MyD88-independent pathway.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c48 : 1
stoichiometry:c83 : 1
m310329*m41*0.1
nodelay
--
0
The cytoplasmic domains of the TLRs and members of the interleukin-1 receptor (IL-1R) family contain a conserved signal-transduction module¡½ the Toll-interleukin 1 receptor (TIR) domain through which TIR-containing adaptor molecules recruit the putative serine/threonine kinase, IL-1Rassociated kinase (IRAK)
p28
p28
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c91 : 1
stoichiometry:c103 : 1
stoichiometry:c85 : 1
m33*m165*m54*0.1
nodelay
--
0
For example, stimulation of DCs by Escherichia coli LPS results in the bioactive IL-12 p70 and interferon (IFN)-stimulated genes expression through TLR-4 IL-12 p70 is produced only in response to TLR-4 signaling. c-Rel and NF-_B1/p50 are essential for LPS-induced IL-12 production (Ouaaz, Arron, Zheng, Choi, & Beg, 2002)
p29
p29
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c72 : 1
stoichiometry:c74 : 1
stoichiometry:c73 : 1
m309848*m977*m33*0.1
nodelay
--
0
TIRAP/MyD88-independent pathway downstream of TLR-4 activates IRF-3 through TICAM-1 which in turn induces INF-beta.
p3
p3
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c42 : 1
stoichiometry:c7 : 1
m4*m3962*0.1
nodelay
--
0
PMID: 14643884 The TLRs recognize molecular patterns that are characteristic of particular classes of microorganism, such as lipopolysaccharide (LPS; Gram-negative bacteria), double-stranded RNA (viruses) and mannan (fungi).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c100 : 1
m2*0.1
nodelay
--
0
TIRAP/MyD88-independent pathway downstream of TLR-4 activates IRF-3 through TICAM-1 which in turn induces INF-beta. TIR-containing adaptor molecule (TICAM-1), can activate type I IFN-beta gene promoter directly through interferon response factor (IRF)-3 upon TLR-4 triggering
p3
p31
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1
m1642*m1636*0.1
nodelay
--
0
Secreted IFN-beta then binds to type I IFN alpha/beta receptor and instigates an autocrine/paracrine loop leading to the production of a set of secondary genes, such as IP-10, ISG15 and many of which are involved in antiviral and/or antimicrobial responses
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c96 : 1
m11*0.1
nodelay
--
0
Secreted IFN-beta then binds to type I IFN alpha/beta receptor and instigates an autocrine/paracrine loop leading to the production of a set of secondary genes, such as IP-10, ISG15 and many of which are involved in antiviral and/or antimicrobial responses
p22
p33
cso30:i:ME_UnknownProduction
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c97 : 1
m11*0.1
nodelay
--
0
Secreted IFN-beta then binds to type I IFN alpha/beta receptor and instigates an autocrine/paracrine loop leading to the production of a set of secondary genes, such as IP-10, ISG15 and many of which are involved in antiviral and/or antimicrobial responses
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
m13*0.1
nodelay
--
0
TIR-containing adaptor molecule (TICAM-1), can activate type I IFN-beta gene promoter directly through interferon response factor (IRF)-3 upon TLR-4 triggering
p35
p35
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c108 : 1
stoichiometry:c107 : 1
m14*m12*0.1
nodelay
--
0
PKC ¦Å is a downstream target of LPS signals that leads to NF-_B and MAPKs activation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
m58*0.1
nodelay
--
0
novel PKC ¦Å plays an important role in Toll-like receptor 4 (TLR-4) signaling that drives IL-12-dependent TH 1 responses of the host immune system.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
m51*0.1
nodelay
--
0
novel PKC ¦Å plays an important role in Toll-like receptor 4 (TLR-4) signaling that drives IL-12-dependent TH 1 responses of the host immune system.
p38
p38
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p39
p39
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p4
p4
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c17 : 1
stoichiometry:c51 : 1
m184*m12*0.1
nodelay
--
0
PMID: 14643884, 11937546 LPS inducible IRAK activation/degradation has been demonstrated to require a functional TLR-4 that can be inhibited by a protein kinase C inhibitor, calphostin
--
and
custom
custom:1
1
nodelay
--
0
--
p38
p41
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p42
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p43
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p44
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p45
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p46
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p47
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p48
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p49
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p5
p5
cso30:i:ME_UnknownDegradation
cso30:i:CC_Cytosol
--
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c10 : 1
m184*m12*0.1
nodelay
--
0
PMID: 14643884, 11937546 LPS inducible IRAK activation/degradation has been demonstrated to require a functional TLR-4 that can be inhibited by a protein kinase C inhibitor, calphostin
p38
p50
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p51
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p52
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p53
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p54
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p55
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p56
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p57
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p58
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p59
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c18 : 1
stoichiometry:c38 : 1
stoichiometry:c16 : 1
m1*m3961*0.1
nodelay
--
0
PMID: 14643884 The TLRs recognize molecular patterns that are characteristic of particular classes of microorganism, such as lipopolysaccharide (LPS; Gram-negative bacteria), double-stranded RNA (viruses) and mannan (fungi). PMID: 14643884, 11937546 LPS inducible IRAK activation/degradation has been demonstrated to require a functional TLR-4 that can be inhibited by a protein kinase C inhibitor, calphostin.
p38
p60
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p61
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p62
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p63
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p64
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p65
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p66
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p67
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p68
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p69
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c13 : 1
stoichiometry:c19 : 1
m1*m9*0.1
nodelay
--
0
PMID: 14643884, 11696589, 9398616, 12385023 There is evidence that LPS stimulation of macrophages or DCs results in PKC activation.
p38
p70
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p71
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p72
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p73
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p74
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p75
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p76
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p77
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p78
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p79
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c22 : 1
stoichiometry:c24 : 1
m15*m16*0.1
nodelay
--
0
Binding of RACK to PKC isoforms
p38
p80
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p81
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p82
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p39
p83
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
and
custom
custom:1
1
nodelay
--
0
--
p38
p84
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p85
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p86
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p87
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p88
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p89
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p1
p9
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c25 : 1
stoichiometry:c28 : 1
m2828*m3964*0.1
nodelay
--
0
TLR-4 and TLR-2 require the co-receptor, CD14 and a secreted protein, MD-2 to transmit LPS or PGN signals.
p38
p90
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p91
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p92
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p93
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p94
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p95
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p96
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p97
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p98
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
p38
p99
cso30:i:ME_UnknownDegradation
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
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0
1,
--
cso30:c:OutputProcess
threshold
--
0
--
cso30:c:InputProcess
threshold
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0
1,
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cso30:c:OutputProcess
threshold
--
0
--
cso30:c:InputProcess
threshold
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0
1,
--
cso30:c:InputProcess
threshold
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0
1,
--
cso30:c:OutputProcess
threshold
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0
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cso30:c:InputProcess
threshold
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0
1,
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cso30:c:OutputProcess
threshold
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0
--
cso30:c:InputProcess
threshold
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0
1,
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cso30:c:InputProcess
threshold
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0
1,
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cso30:c:OutputProcess
threshold
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0
--
cso30:c:InputProcess
threshold
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1,
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cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
threshold
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1,
--
cso30:c:InputProcess
threshold
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0
1,
--
cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
threshold
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1,
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cso30:c:InputProcess
threshold
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1,
--
cso30:c:InputProcess
threshold
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cso30:c:InputProcess
threshold
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cso30:c:InputProcess
threshold
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cso30:c:InputProcess
threshold
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1,
--
cso30:c:InputProcess
threshold
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1,
--
cso30:c:InputProcess
threshold
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1,
--
cso30:c:InputProcess
threshold
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1,
--
cso30:c:OutputProcess
threshold
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0
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cso30:c:OutputProcess
threshold
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1,
--
cso30:c:InputProcess
threshold
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0
1,
--
cso30:c:OutputProcess
threshold
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0
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cso30:c:InputProcess
threshold
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1,
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cso30:c:InputProcess
threshold
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1,
--
cso30:c:InputProcess
threshold
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cso30:c:InputProcess
threshold
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0
1,
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cso30:c:OutputProcess
threshold
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0
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cso30:c:InputProcess
threshold
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1,
--
cso30:c:InputProcess
threshold
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0
1,
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cso30:c:InputAssociation
threshold
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0
1,
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cso30:c:OutputProcess
threshold
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0
--
cso30:c:InputProcess
threshold
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1,
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cso30:c:InputProcess
threshold
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1,
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cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
threshold
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1,
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cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
threshold
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0
1,
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cso30:c:InputProcess
threshold
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0
1,
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cso30:c:OutputProcess
threshold
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0
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cso30:c:InputInhibitor
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0
1,
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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1,
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cso30:c:InputProcess
threshold
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1,
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cso30:c:InputProcess
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0
1,
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cso30:c:OutputProcess
threshold
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0
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cso30:c:InputProcess
threshold
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0
1,
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cso30:c:InputProcess
threshold
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1,
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cso30:c:InputProcess
threshold
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0
1,
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cso30:c:OutputProcess
threshold
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0
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
threshold
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputAssociation
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:InputAssociation
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:OutputProcess
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cso30:c:OutputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:InputAssociation
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cso30:c:InputAssociation
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:OutputProcess
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:InputAssociation
threshold
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cso30:c:InputProcess
threshold
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cso30:c:InputAssociation
threshold
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cso30:c:InputAssociation
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
threshold
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cso30:c:InputAssociation
threshold
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cso30:c:InputProcess
threshold
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--
cso30:c:InputProcess
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:InputAssociation
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cso30:c:OutputProcess
threshold
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1,
--
cso30:c:InputProcess
threshold
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1,
--
cso30:c:InputProcess
threshold
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1,
--
cso30:c:InputProcess
threshold
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1,
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cso30:c:InputAssociation
threshold
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cso30:c:InputAssociation
threshold
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1,
--
cso30:c:InputAssociation
threshold
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1,
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cso30:c:InputAssociation
threshold
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1,
--
cso30:c:InputProcess
threshold
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1,
--
cso30:c:OutputProcess
threshold
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0
1,
--
cso30:c:OutputProcess
threshold
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0
1,
--
cso30:c:InputAssociation
threshold
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0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--