1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/14644140.csml convertedTime:2009.07.01.10:43

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Regulation of cytokine signaling by SOCS family molecules.
Authors Fujimoto M, Naka T.
Affiliation Department of Molecular Medicine, Osaka University Graduate School of Medicine,2-2, Yamadaoka, Suita City, Osaka, Japan.
Abstract Cytokine signaling is dependent on the activation of intracellular molecules,including JAKs (Janus family kinases) and STATs (signal transducers andactivators of transcription). Since the discovery of the SOCS (suppressor ofcytokine signaling) family molecules in 1997, extensive investigation of thesemolecules has given important insights into the as yet unclarified regulatorymechanisms of cytokine signaling. Recent gene targeting analyses of SOCSmolecules have revealed that they do indeed have essential roles in vivo (morespecific than those expected from overexpression studies in vitro) in thenegative regulation of various cytokines. Moreover, consistent with thepathological actions of cytokines in human diseases, recent lines of evidencealso indicate that SOCS molecules are implicated in autoimmunity, allergy andcancers.
PMID 14644140
Model Abstract

Entity

G010539:SOCS1 G012007:SOCS5 G014721:IGF1 MO000000011:ERK MO000000044:Vav MO000000154:IRS-1 MO000000213:IRAK MO000004670:ERK1 MO000004676:ERK2 MO000007384:IL-6 MO000007556:insulin MO000013119:STAT1 MO000013133:STAT5B MO000016866:IRS-4 MO000016876:STAT5 MO000016882:LPS MO000017004:SOCS-1 MO000017061:IL-2 MO000017094:IGF-1 MO000017116:CIS MO000017120:SOCS-2 MO000017121:SOCS-3 MO000017329:GHR MO000017890:GH MO000035128:SOCS-5 MO000062651:SOCS6 e1: e10: e11:IL-2:IL-2R e12:IL-3:IL-3R e13:LIgand:EpoR:CIS e14:Ligand:Prolactin e15:CpGDNA e16:JAK e17:SOCS-1:JAK e18:SOCS-1:Vav e19:SOCS-1:IRS-1 e2: e20:SOCS-1:iRAK e21:GH:GHR:SOCS-2 e22:GH:GHR e23:STAT5B{active} e24:IGF-1:IGF-1R e25:SOCS-3{p} e26:ERK{active} e27:LIgand:EpoR{ub}:CIS e28:Insulin:Insulin receptor e29:ERK1{active} e3: e30:ERK2{active} e31:protein kinase B e32:protein kinase B {active} e33:IRS-1{active} e34:SOCS6:IRS-4 e35:Ligand:gp130 e36:IL-2:IL-2R:CIS e37:STAT1{active} e38:IFN responsive genes e39:Ligand:Prolactin:CIS e4: e40:Ligand:EpoR:SOCS-3 e41:IL-3:IL-3R:CIS e42:Ligand:gp130:SOCS-3 e43:IGF-1:IGF-1R:SOCS-2 e44:Insulin:Insulin receptor:SOCS6 e45:Ligand e46:SOCS-1:Vav{ub} e47:degradants e48:SOCS-1:IRS-1{ub} e49:SOCS-1:JAK{ub} e5:Ligand:EpoR e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:GH:GHR:CIS e60: e61: e62: e63:STAT5{active} e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p5 p6 p7 p8 p9
Model Detail
657.0, 961.0
29.0, 29.0

SOCS1

--

G010539

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p6 p7 p8

--

true true true true

csml-variable:Double

m93501

10

false

infinite

0

unit false false false
TRANSFACG010539

--

Go back
627.0, 895.0
26.0, 26.0

SOCS5

--

G012007

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m94812

10

false

infinite

0

unit false false false
TRANSFACG012007

--

Go back
561.0, 925.0
29.5, 29.5

IGF1

--

G014721

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m96897

10

false

infinite

0

unit false false false
TRANSFACG014721

--

Go back
826.0, 458.0
28.0, 28.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
653.0, 481.0
22.0, 22.0

Vav

--

MO000000044

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000044

--

Go back
412.0, 616.0
16.0, 16.0

IRS-1

--

MO000000154

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p25

true true true true

csml-variable:Double

m135

10

false

infinite

0

unit false false false
InterProIPR002404
TRANSPATHMO000000154

--

Go back
528.0, 352.0
16.0, 16.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
268.0, 988.0
24.0, 24.0

ERK1

--

MO000004670

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m549

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
304.0, 880.0
24.0, 24.0

ERK2

--

MO000004676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m554

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
1090.0, 654.0
20.0, 20.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p29

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
1083.0, 911.0
25.5, 25.5

insulin

--

MO000007556

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m908

10

false

infinite

0

unit false false false
InterProIPR004825
TRANSPATHMO000007556

--

Go back
833.0, 609.0
22.0, 22.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
245.0, 433.0
21.0, 21.0

STAT5B

--

MO000013133

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m1371

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013133

--

Go back
542.0, 666.0
19.0, 19.0

IRS-4

--

MO000016866

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m1793

10

false

infinite

0

unit false false false
InterProIPR002404
TRANSPATHMO000016866

--

Go back
401.0, 429.0
22.0, 22.0

STAT5

--

MO000016876

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p40 p41 p42 p43

true true true true

csml-variable:Double

m1798

10

false

infinite

0

unit false false false
TRANSPATHMO000016876

--

Go back
1085.0, 977.0
29.0, 29.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
596.0, 444.0
15.5, 15.5

SOCS-1

--

MO000017004

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35 p36 p38

p9 p10 p11 p12

true true true true

csml-variable:Double

m1906

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017004

--

Go back
830.0, 110.0
19.0, 19.0

IL-2

--

MO000017061

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m1954

10

false

infinite

0

unit false false false
TRANSPATHMO000017061

--

Go back
96.0, 644.0
24.0, 24.0

IGF-1

--

MO000017094

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

--

true true true true

csml-variable:Double

m1985

10

false

infinite

0

unit false false false
InterProIPR004825
TRANSPATHMO000017094

--

Go back
307.0, 323.0
18.0, 18.0

CIS

--

MO000017116

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

p1 p2 p3 p4 p5

true true true true

csml-variable:Double

m2003

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017116

--

Go back
320.0, 432.0
16.0, 16.0

SOCS-2

--

MO000017120

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p17

true true true true

csml-variable:Double

m2004

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017120

--

Go back
784.0, 296.0
16.0, 16.0

SOCS-3

--

MO000017121

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p27 p28

true true true true

csml-variable:Double

m2005

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017121

--

Go back
353.0, 169.0
22.0, 22.0

GHR

--

MO000017329

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p14

true true true true

csml-variable:Double

m2174

10

false

infinite

0

unit false false false
InterProIPR003528
TRANSPATHMO000017329

--

Go back
105.0, 285.0
22.0, 22.0

GH

--

MO000017890

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m2633

10

false

infinite

0

unit false false false
TRANSPATHMO000017890

--

Go back
730.0, 598.0
20.0, 20.0

SOCS-5

--

MO000035128

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

--

true true true true

csml-variable:Double

m13647

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000035128

--

Go back
359.0, 783.0
18.0, 18.0

SOCS6

--

MO000062651

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p26

true true true true

csml-variable:Double

m37538

10

false

infinite

0

unit false false false
TRANSPATHMO000062651

--

Go back
154.33436890075183, 142.25025641458285
906.5857095058703, 1316.3624502025245

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
169.76947715384242, 192.5699534541351
835.8824091212709, 1175.851512397899

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
544.5, 154.0
22.25257618943214, 43.06950230212673

IL-2:IL-2R

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
669.5, 144.0
20.59416794562596, 39.85967989475992

IL-3:IL-3R

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
413.5, 149.0
21.60653330886401, 30.148651128647465

LIgand:EpoR:CIS

--

e13

cso30:c:Complex

cso30:i:CC_Extracellular

--

p1

p31 p43

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
180.5, 181.0
23.6730980048235, 45.81889936417452

Ligand:Prolactin

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1094.0, 1056.0
60.0, 16.0

CpGDNA

--

e15

cso30:c:Dna

cso30:i:CC_Nucleolus

--

--

p8

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
688.0, 251.5
23.200000000000006, 17.40000000000001

JAK

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
670.0, 405.0
19.441988950276247, 21.602209944751383

SOCS-1:JAK

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p37

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
565.0, 576.0
22.127071823204417, 24.585635359116015

SOCS-1:Vav

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p34

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
554.0, 625.0
20.685082872928174, 22.98342541436465

SOCS-1:IRS-1

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p33

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
154.33436890075183, 142.25025641458285
906.5857095058703, 1316.3624502025245

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
529.0, 392.0
21.381215469613256, 23.756906077348063

SOCS-1:iRAK

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
172.5, 368.0
23.334740319324652, 32.56010277115067

GH:GHR:SOCS-2

--

e21

cso30:c:Complex

cso30:i:CC_Extracellular

--

p13

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
176.5, 273.0
23.6730980048235, 45.81889936417452

GH:GHR

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p2 p13 p15 p16

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
249.0, 529.0
21.0, 21.0

STAT5B{active}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

--

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013133

--

Go back
180.5, 607.0
22.01468976101732, 42.60907695680772

IGF-1:IGF-1R

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p17

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
853.0, 392.0
26.46341463414635, 21.170731707317067

SOCS-3{p}

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
926.0, 542.0
28.0, 28.0

ERK{active}

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19

--

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
921.5, 145.0
21.60653330886401, 30.148651128647465

LIgand:EpoR{ub}:CIS

--

e27

cso30:c:Complex

cso30:i:CC_Extracellular

--

p31

p32

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
180.5, 814.0
22.884674413505813, 44.292918219688666

Insulin:Insulin receptor

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p21

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
392.0, 948.0
24.0, 24.0

ERK1{active}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22

--

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
172.4660830908692, 160.3819706047003
870.3222811256356, 1280.0990218222912

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
396.0, 888.0
24.0, 24.0

ERK2{active}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

--

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
269.0, 647.5
22.56, 16.919999999999995

protein kinase B

--

e31

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p24

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
369.0, 727.5
22.56, 16.919999999999995

protein kinase B {active}

--

e32

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p24

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
452.0, 668.0
16.0, 16.0

IRS-1{active}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

--

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
InterProIPR002404
TRANSPATHMO000000154

--

Go back
614.5, 704.0
18.98433594400932, 23.246125645725705

SOCS6:IRS-4

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1018.5, 325.0
19.696996272747207, 38.12321859241394

Ligand:gp130

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
592.5, 139.0
23.800330335841437, 33.20976325931364

IL-2:IL-2R:CIS

--

e36

cso30:c:Complex

cso30:i:CC_Extracellular

--

p3

p41

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
885.0, 705.0
22.0, 22.0

STAT1{active}

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

p30

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
769.0, 870.0
37.57785467128028, 20.041522491349482

IFN responsive genes

--

e38

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p30

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
227.5, 155.0
24.64470545054138, 34.38796109377868

Ligand:Prolactin:CIS

--

e39

cso30:c:Complex

cso30:i:CC_Extracellular

--

p5

p39

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
206.00975434258658, 192.11247043740576
803.2349386222015, 1216.6380221568775

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1016.5, 264.0
23.208478619930265, 32.38392365571665

Ligand:EpoR:SOCS-3

--

e40

cso30:c:Complex

cso30:i:CC_Extracellular

--

p28

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
746.5, 138.0
26.46760873554781, 36.931547072857406

IL-3:IL-3R:CIS

--

e41

cso30:c:Complex

cso30:i:CC_Extracellular

--

p4

p42

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1015.5, 391.0
24.786749862360068, 34.58616259864195

Ligand:gp130:SOCS-3

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
179.5, 555.0
24.723619012662876, 34.498073040924936

IGF-1:IGF-1R:SOCS-2

--

e43

cso30:c:Complex

cso30:i:CC_Extracellular

--

p17

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
175.5, 723.0
24.557900532207743, 34.266837951917786

Insulin:Insulin receptor:SOCS6

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p22 p23 p24 p25

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1014.0, 88.5
26.045694200351488, 16.92970123022847

Ligand

--

e45

cso30:c:Protein

cso30:i:CC_Extracellular

--

p32

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
701.0, 544.0
22.127071823204417, 24.585635359116015

SOCS-1:Vav{ub}

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p35

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
830.0, 538.0
19.781734635267092, 19.122343480758182

degradants

--

e47

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p35 p36 p38

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
374.0, 521.0
20.685082872928174, 22.98342541436465

SOCS-1:IRS-1{ub}

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p36

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
766.0, 405.0
19.441988950276247, 21.602209944751383

SOCS-1:JAK{ub}

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p38

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
469.5, 132.0
20.4242490681868, 39.53080464810349

Ligand:EpoR

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p1 p28

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
453.99617041201594, 750.4472075194319
435.3645960487354, 394.82785526207493

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
501.01878972454233, 759.8040536997261
254.570732140229, 382.66683302607663

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
459.67131412214843, 755.7169838216975
424.01430862847064, 384.28830265754306

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
460.48204893788136, 756.5277186374312
422.3928389970042, 382.66683302607663

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
453.99617041201594, 750.4472075194319
435.3645960487354, 394.82785526207493

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
453.99617041201594, 750.4472075194319
435.3645960487354, 394.82785526207493

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
460.48204893788136, 756.5277186374312
422.3928389970042, 382.66683302607663

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
771.8042181794353, 912.5941706660742
27.1991878485784, 24.62242268397625

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
700.4595543949121, 1026.0970448687242
77.01980749465521, 69.7231941530564

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
453.99617041201594, 750.4472075194319
435.3645960487354, 394.82785526207493

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
291.5, 142.0
25.528537346302077, 35.62121490181685

GH:GHR:CIS

--

e6

cso30:c:Complex

cso30:i:CC_Extracellular

--

p2

p40

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
556.6091560727327, 925.9054439084716
13.787357055786226, 6.638357100934118

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
556.1487571944008, 906.1082921402091
47.1908850289993, 84.94359305219866

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
575.9459089626648, 961.3561575400126
7.366382053307195, 7.366382053307205

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
473.0, 481.0
22.0, 22.0

STAT5{active}

--

e63

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39 p40 p41 p42 p43

--

true true true true

csml-variable:Double

m65

10

false

infinite

0

unit false false false
TRANSPATHMO000016876

--

Go back
175.8367892458752, 154.36560460164517
858.5649226186207, 1216.5643183968648

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
178.90410133790812, 175.83678924587528
823.6315607305086, 1195.913026180699

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
186.08360024999587, 214.30797389010556
819.8712308655354, 1180.228926511029

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
394.0, 250.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017116 e5

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c3 : 1
stoichiometry:c80 : 1

m2003*m5*0.1

nodelay

--

true

0

false

PMID: 14644140,9129017,10585430 The SH2 domain of the CIS associates with STAT5-binding sites of various types of receptor, including growth hormone (GH) receptors and EPO receptors

Go back
586.0, 506.0
19.0, 19.0

p9

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000044 MO000017004

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c25 : 1
stoichiometry:c27 : 1

m41*m1906*0.1

nodelay

--

true

0

false

PMID: 14644140 Based on the results of in vitro studies using cell lines forcedly expressing SOCS-1, it has been confirmed that SOCS-1 inhibits various types of signal transduction through its binding to JAK and possibly other signaling molecules, such as Vav, IRS-1 sand IL-1 receptor-associated kinase (IRAK)

Go back
502.0, 538.0
19.0, 19.0

p9

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017004 MO000000154

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m1906*m135*0.1

nodelay

--

true

0

false

PMID: 14644140 Based on the results of in vitro studies using cell lines forcedly expressing SOCS-1, it has been confirmed that SOCS-1 inhibits various types of signal transduction through its binding to JAK and possibly other signaling molecules, such as Vav, IRS-1 sand IL-1 receptor-associated kinase (IRAK)

Go back
598.0, 350.0
19.0, 19.0

p9

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017004 MO000000213

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m1906*m184*0.1

nodelay

--

true

0

false

PMID: 14644140 Based on the results of in vitro studies using cell lines forcedly expressing SOCS-1, it has been confirmed that SOCS-1 inhibits various types of signal transduction through its binding to JAK and possibly other signaling molecules, such as Vav, IRS-1 sand IL-1 receptor-associated kinase (IRAK)

Go back
318.0, 370.0
19.0, 19.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017120 e22

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c89 : 1
stoichiometry:c34 : 1

m2004*m22*0.1

nodelay

--

true

0

false

PMID: 14644140,12208853,10403376 SOCS-2 is known to bind to the SHP2-binding site of activated GH receptors and to inhibit the activation of STAT5b induced by GH

Go back
105.0, 217.0
21.0, 21.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017890 MO000017329

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m2633*m2174*0.1

nodelay

--

true

0

false

PMID: 14644140,12208853,10403376 SOCS-2 is known to bind to the SHP2-binding site of activated GH receptors and to inhibit the activation of STAT5b induced by GH

Go back
242.0, 486.0
19.0, 19.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013133 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m1371*m22*0.1

nodelay

--

true

0

false

PMID: 14644140,12208853,10403376 SOCS-2 is known to bind to the SHP2-binding site of activated GH receptors and to inhibit the activation of STAT5b induced by GH

Go back
410.0, 694.0
19.0, 19.0

p16

p16

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G014721 e22

MO000017094

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c44 : 1

m96897*m22*0.1

nodelay

--

true

0

false

Growth promotion by GH is dependent on the induction of insulin-like growth factor-1 (IGF-1) by GH, whereas SOCS-2-deficient mice do not exhibit an increase in serum IGF-1.

Go back
257.0, 585.0
21.0, 21.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017120 e24

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c49 : 1
stoichiometry:c43 : 1

m2004*m24*0.1

nodelay

--

true

0

false

PMID: 14644140,12208853,9727029 SOCS-2 binds not only to GH receptors but also to IGF-1 receptors

Go back
822.0, 342.0
19.0, 19.0

p18

p18

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017061 MO000017121

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m1954*m2005*0.1

nodelay

--

true

0

false

PMID: 14644140,11331873 In addition, in vitro data have suggested that SOCS-3 undergoes tyrosine-phosphorylation on stimulation with IL-2 and appears to accelerate the activation of ErK (extracellular-signal-regulated kinase) by acting as an adaptor molecule

Go back
909.0, 461.0
21.0, 21.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000011 e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c55 : 1
stoichiometry:c54 : 1

m26*m25*0.1

nodelay

--

true

0

false

PMID: 14644140,11331873 In addition, in vitro data have suggested that SOCS-3 undergoes tyrosine-phosphorylation on stimulation with IL-2 and appears to accelerate the activation of ErK (extracellular-signal-regulated kinase) by acting as an adaptor molecule

Go back
294.0, 226.0
19.0, 19.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017116 MO000017329 e22

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
stoichiometry:c88 : 1

m2003*m2174*m22*0.1

nodelay

--

true

0

false

PMID: 14644140,9129017,10585430 The SH2 domain of the CIS associates with STAT5-binding sites of various types of receptor, including growth hormone (GH) receptors and EPO receptors PMID: 14644140,7796808 Initial in vitro studies reported CIS as an inhibitor of the signal transduction of EPO, interleukin-2 (IL-2), IL-3, GH and prolactin, by masking the STAT5-binding sites of receptors and inhibiting the activation of STAT5.

Go back
690.0, 650.0
22.0, 22.0

p20

p20

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G012007 MO000007384

MO000035128

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c58 : 1
stoichiometry:c57 : 1

m94812*m871*0.1

nodelay

--

true

0

false

PMID: 14644140,9889194 SOCS-5 is induced in M1 cell lines in response to stimulation with IL-6 and marginally inhibits IL-6 signaling

Go back
273.0, 817.0
21.0, 21.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000062651 e28

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c48 : 1
stoichiometry:c61 : 1

m37538*m29*0.1

nodelay

--

true

0

false

PMID: 14644140,11342531 SOCS-6 binds to insulin receptors and inhibits the activation of Erk1/2, protein kinase B and IRS-1

Go back
270.0, 918.0
19.0, 19.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000004670 e44

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c78 : 1
stoichiometry:c63 : 1

m549*0.1

nodelay

--

true

0

false

PMID: 14644140,11342531 SOCS-6 binds to insulin receptors and inhibits the activation of Erk1/2, protein kinase B and IRS-1

Go back
362.0, 826.0
19.0, 19.0

p22

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000004676 e44

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c64 : 1
stoichiometry:c67 : 1

m554*0.1

nodelay

--

true

0

false

PMID: 14644140,11342531 SOCS-6 binds to insulin receptors and inhibits the activation of Erk1/2, protein kinase B and IRS-1

Go back
290.0, 750.0
19.0, 19.0

p22

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 e44

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c65 : 1
stoichiometry:c70 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 14644140,11342531 SOCS-6 binds to insulin receptors and inhibits the activation of Erk1/2, protein kinase B and IRS-1

Go back
334.0, 642.0
19.0, 19.0

p22

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000154 e44

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c68 : 1
stoichiometry:c73 : 1

m135*0.1

nodelay

--

true

0

false

PMID: 14644140,11342531 SOCS-6 binds to insulin receptors and inhibits the activation of Erk1/2, protein kinase B and IRS-1

Go back
502.0, 730.0
19.0, 19.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000062651 MO000016866

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m37538*m1793*0.1

nodelay

--

true

0

false

PMID: 14644140,12052866 Interestingly, a recent study has reported that SOCS-6 binds to IRS-4, a molecule with an important role in insulin signaling, and that SOCS-6-deficient mice exhibit mild growth retardation

Go back
881.0, 293.0
21.0, 21.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017121

e35 e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c79 : 1
stoichiometry:c36 : 1

m2005*0.1

nodelay

--

true

0

false

PMID: 14644140,12626585 It is noteworthy that this notion is in line with the recent finding that SOCS-3 associates with gp130 but not with the IL-10 receptor (IL-10R), and endogenous SOCS-3 induced by cytokines inhibits IL-6 signaling but not IL-10 signaling in human macrophages PMID: 14644140 SOCS-3 inhibits the function of JAK by binding to the Src homology phosphatase-2 (SHP-2)-binding domain of gp130 and the EPORs

Go back
806.0, 246.0
19.0, 19.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017121 e5

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c2 : 1
stoichiometry:c82 : 1

m2005*m5*0.1

nodelay

--

true

0

false

PMID: 14644140 SOCS-3 inhibits the function of JAK by binding to the Src homology phosphatase-2 (SHP-2)-binding domain of gp130 and the EPORs

Go back
920.0, 608.0
23.0, 23.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007384 MO000013119

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m871*m1357*0.1

nodelay

--

true

0

false

PMID: 14644140,12754506 Other groups showed that IL-6 strongly activates STAT1 and induces the expression of IFN-responsive genes in SOCS-3 deficient macrophages, implying that IL-6 could mimic the action of IFNs

Go back
501.0, 257.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017116 e11

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c9 : 1
stoichiometry:c8 : 1

m2003*m11*0.1

nodelay

--

true

0

false

PMID: 14644140,7796808 Initial in vitro studies reported CIS as an inhibitor of the signal transduction of EPO, interleukin-2 (IL-2), IL-3, GH and prolactin, by masking the STAT5-binding sites of receptors and inhibiting the activation of STAT5.

Go back
725.0, 813.0
21.0, 21.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 14644140,12754506 Other groups showed that IL-6 strongly activates STAT1 and induces the expression of IFN-responsive genes in SOCS-3 deficient macrophages, implying that IL-6 could mimic the action of IFNs

Go back
473.0, 225.0
21.0, 21.0

p31

p31

cso30:i:ME_Ubiquitination

cso30:i:CC_Extracellular

--

e13

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c71 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 14644140,9774439 CIS is also involved in the ubiquitination and degradation of EPO receptors

Go back
882.0, 218.0
19.0, 19.0

p32

p32

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e27

e45 MO000017116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 14644140,9774439 CIS is also involved in the ubiquitination and degradation of EPO receptors

Go back
374.0, 574.0
19.0, 19.0

p33

p33

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e19

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 14644140,10747851,12228220,11971965 Indeed, SOCS-1 accelerates ubiquitination and degradation of Vav, insulin receptor substrate-1 (IRS-1) and JAKs that can associate with SOCS-1

Go back
629.0, 565.0
21.0, 21.0

p34

p34

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e18

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 14644140,10747851,12228220,11971965 Indeed, SOCS-1 accelerates ubiquitination and degradation of Vav, insulin receptor substrate-1 (IRS-1) and JAKs that can associate with SOCS-1

Go back
741.0, 517.0
21.0, 21.0

p35

p35

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e46

MO000017004 e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 14644140,10747851,12228220,11971965 Indeed, SOCS-1 accelerates ubiquitination and degradation of Vav, insulin receptor substrate-1 (IRS-1) and JAKs that can associate with SOCS-1

Go back
433.0, 521.0
21.0, 21.0

p36

p36

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e48

MO000017004 e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 14644140,10747851,12228220,11971965 Indeed, SOCS-1 accelerates ubiquitination and degradation of Vav, insulin receptor substrate-1 (IRS-1) and JAKs that can associate with SOCS-1

Go back
722.0, 346.0
19.0, 19.0

p33

p37

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e17

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 14644140,10747851,12228220,11971965 Indeed, SOCS-1 accelerates ubiquitination and degradation of Vav, insulin receptor substrate-1 (IRS-1) and JAKs that can associate with SOCS-1

Go back
737.0, 457.0
21.0, 21.0

p35

p38

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e49

MO000017004 e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 14644140,10747851,12228220,11971965 Indeed, SOCS-1 accelerates ubiquitination and degradation of Vav, insulin receptor substrate-1 (IRS-1) and JAKs that can associate with SOCS-1

Go back
361.0, 365.0
17.0, 17.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016876 e39

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c109 : 1

m1798*0.1

nodelay

--

true

0

false

PMID: 14644140,7796808 Initial in vitro studies reported CIS as an inhibitor of the signal transduction of EPO, interleukin-2 (IL-2), IL-3, GH and prolactin, by masking the STAT5-binding sites of receptors and inhibiting the activation of STAT5.

Go back
589.0, 317.0
21.0, 21.0

p3

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017116

e12 e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c12 : 1
stoichiometry:c11 : 1

m2003*0.1

nodelay

--

true

0

false

PMID: 14644140,7796808 Initial in vitro studies reported CIS as an inhibitor of the signal transduction of EPO, interleukin-2 (IL-2), IL-3, GH and prolactin, by masking the STAT5-binding sites of receptors and inhibiting the activation of STAT5.

Go back
399.0, 331.0
17.0, 17.0

p39

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e6 MO000016876

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m1798*0.1

nodelay

--

true

0

false

PMID: 14644140,7796808 Initial in vitro studies reported CIS as an inhibitor of the signal transduction of EPO, interleukin-2 (IL-2), IL-3, GH and prolactin, by masking the STAT5-binding sites of receptors and inhibiting the activation of STAT5.

Go back
475.0, 339.0
17.0, 17.0

p39

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 MO000016876

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m1798*0.1

nodelay

--

true

0

false

PMID: 14644140,7796808 Initial in vitro studies reported CIS as an inhibitor of the signal transduction of EPO, interleukin-2 (IL-2), IL-3, GH and prolactin, by masking the STAT5-binding sites of receptors and inhibiting the activation of STAT5.

Go back
543.0, 299.0
17.0, 17.0

p39

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e41 MO000016876

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1

m1798*0.1

nodelay

--

true

0

false

PMID: 14644140,7796808 Initial in vitro studies reported CIS as an inhibitor of the signal transduction of EPO, interleukin-2 (IL-2), IL-3, GH and prolactin, by masking the STAT5-binding sites of receptors and inhibiting the activation of STAT5.

Go back
435.0, 311.0
17.0, 17.0

p39

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016876 e13

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c122 : 1
stoichiometry:c121 : 1

m1798*0.1

nodelay

--

true

0

false

PMID: 14644140,7796808 Initial in vitro studies reported CIS as an inhibitor of the signal transduction of EPO, interleukin-2 (IL-2), IL-3, GH and prolactin, by masking the STAT5-binding sites of receptors and inhibiting the activation of STAT5.

Go back
253.0, 273.0
21.0, 21.0

p3

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017116 e14

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c14 : 1

m2003*m14*0.1

nodelay

--

true

0

false

PMID: 14644140,7796808 Initial in vitro studies reported CIS as an inhibitor of the signal transduction of EPO, interleukin-2 (IL-2), IL-3, GH and prolactin, by masking the STAT5-binding sites of receptors and inhibiting the activation of STAT5.

Go back
766.0, 918.0
20.0, 20.0

p6

p6

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000007556

G010539

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1

m908*0.1

nodelay

--

true

0

false

PMID: 14644140,10453004,11390452,12433365,12433373,11208867 However, SOCS-1 expression is now known to be induced by insulin, lipopolysaccharide (LPS), CpG DNA and other molecules that do not use STATs in signal transduction

Go back
770.0, 970.0
20.0, 20.0

p6

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000016882

G010539

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 14644140,10453004,11390452,12433365,12433373,11208867 However, SOCS-1 expression is now known to be induced by insulin, lipopolysaccharide (LPS), CpG DNA and other molecules that do not use STATs in signal transduction

Go back
770.0, 1018.0
20.0, 20.0

p6

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e15

G010539

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 14644140,10453004,11390452,12433365,12433373,11208867 However, SOCS-1 expression is now known to be induced by insulin, lipopolysaccharide (LPS), CpG DNA and other molecules that do not use STATs in signal transduction

Go back
670.0, 330.0
19.0, 19.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017004 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m1906*m16*0.1

nodelay

--

true

0

false

PMID: 14644140 Based on the results of in vitro studies using cell lines forcedly expressing SOCS-1, it has been confirmed that SOCS-1 inhibits various types of signal transduction through its binding to JAK and possibly other signaling molecules, such as Vav, IRS-1 sand IL-1 receptor-associated kinase (IRAK) PMID: 14644140 Currently, SOCS-1 is thought to inhibit the catalytic activity of JAKs by directly binding to the JAK activation loop with both its SH2 and KIR domains and preventing the access of JAK substrates with its KIR domain.

Go back
325.0, 273.09505157597033

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
325.0, 328.12119821037015

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
395.0, 532.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.0, 459.5777087639997

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
454.0, 532.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
689.0, 371.020613557655

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
739.0, 365.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
757.7647058823529, 427.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.9502911748085, 453.89043261157855

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
758.0, 477.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
379.30428362337494, 388.7433776766207

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
378.0, 382.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
610.0, 175.8524123740445

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
251.0, 189.0

c110

c110

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
314.0, 178.0

c111

c111

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
408.39458089848506, 355.9902631943229

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
412.0, 348.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.1145102500878, 172.0

c114

c114

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
421.0, 362.3055042995707

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
484.0, 356.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
563.2349443372127, 166.0

c117

c117

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
423.0, 321.4859189764302

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
490.7740709305215, 316.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
605.0, 191.18754868322594

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
415.0, 335.72860799360114

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.0, 328.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
426.0, 179.0

c122

c122

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
279.8307845767519, 298.4774036933124

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
245.676232709847, 196.82241931261927

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
204.0, 218.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
793.9992745491421, 924.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
693.2610163262345, 933.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
797.9944441727429, 980.2980979183056

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
693.9949028347804, 977.2855322440993

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
490.0, 155.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
797.9560436233712, 1029.8374782761443

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
693.2228841505914, 986.4394686431388

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
609.0, 355.60245808999866

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
684.9103049700403, 269.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.0, 349.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
598.0347134725422, 460.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.5410178012896, 496.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.1177358542493, 525.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.546327990804, 460.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
428.0, 561.0885814306548

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
415.6350307577579, 167.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.0, 557.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0, 376.98864643742263

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.0, 360.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.7203150221502, 366.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
203.99570354426584, 380.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
328.0, 397.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
902.0, 312.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
116.0, 246.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
133.85382208071974, 182.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
126.0, 237.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
306.01731452788295, 252.9350533174868

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
253.49902628924144, 454.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
195.0, 319.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
254.0, 505.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
211.6177225322558, 578.4434204348745

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
127.90947903871141, 659.200058888632

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
430.4084922779337, 719.6757168780139

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
200.0, 317.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
274.8864248990313, 448.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
203.0, 829.6832091307715

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
203.0, 604.1348965210016

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
318.7999954687553, 190.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
832.3002577781567, 129.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
799.0, 312.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.0, 361.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
854.0, 472.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
922.0, 482.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
874.0, 413.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
643.0, 679.767247653025

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
709.0, 624.4

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
719.999748059269, 661.0634900639625

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
301.34730092648806, 796.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
200.0, 244.69794865315157

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
435.0, 177.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
205.89388059586426, 756.4094520537384

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
280.0, 945.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
289.0, 930.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
200.0, 746.0

c64

c64

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
200.0, 742.0

c65

c65

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
328.0, 850.6568542494924

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
377.0, 845.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
200.0, 659.9536202379851

c68

c68

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
282.0, 664.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
325.0, 274.46486486486486

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
309.0, 741.2987830845308

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
494.0, 163.32714666507482

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
360.4958416382905, 627.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.0, 654.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
377.0, 746.7097557461819

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
522.2264150943396, 685.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.0, 719.6648611557189

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
800.0, 304.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
196.0, 757.0

c78

c78

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
902.0, 307.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
521.0, 176.16315456899753

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
406.0, 186.82722662522383

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.0, 272.1089652564389

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.0, 257.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
950.7453954596493, 625.0022110712018

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
855.0, 620.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
902.8311367793272, 631.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.6269180010013, 723.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
745.0, 834.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
304.0, 186.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
200.0, 303.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.4813492843222, 197.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
902.0209636589963, 175.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 110.58291781528342

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.8741066185304, 230.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
587.0, 579.49689686312

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
650.0, 561.1177358542493

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
723.0, 540.4376015698018

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.1219853038187, 459.6438064345119

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
762.0, 530.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.69219158112656, 589.197769023179

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
384.0, 552.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back