1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/14698224.csml convertedTime:2009.07.01.10:43

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title TIR domain-containing adaptors define the specificity of TLR signaling.
Authors Yamamoto M, Takeda K, Akira S.
Affiliation Department of Host Defense, Research Institute for Microbial Diseases, OsakaUniversity, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
Abstract The concept that Toll-like receptors (TLRs) recognize specific molecularpatterns in various pathogens has been established. In signal transduction viaTLRs, MyD88, which harbors a Toll/IL-1 receptor (TIR)-domain and a death domain,has been shown to link between TLRs and MyD88-dependent downstream eventsleading to proinflammatory cytokine production and splenocyte proliferation.However, recent studies using MyD88-deficient mice have revealed that some TLRspossess a MyD88-independent pathway, which is represented by interferon(IFN)-beta production induced by LPS stimulation. This indicates that additionalsignaling molecules other than MyD88 exist in the TLR signaling pathway. Indeed,two additional TIR domain-containing adaptors, TIRAP/Mal and TRIF, have recentlybeen identified. Both define the specific biological responses of each TLR.
PMID 14698224
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010389:IL-1beta G010522:RANTES G010657:IL-12 p40 G022992:IFNA4 MO000000058:NF-kappaB MO000000212:TRAF6 MO000000289:TNF-alpha MO000007384:IL-6 MO000007694:IRF-3 MO000016573:MyD88 MO000016597:IL-1beta MO000016882:LPS MO000016894:MAPK MO000019331:TBK1 MO000019394:TLR4 MO000019396:TLR1 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019422:TLR6 MO000022131:MD-2 MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000042012:TLR9 MO000042126:TLR7 MO000043607:IL-12B MO000061564:IFNA4 e1: e10: e11:peptidoglycan e12:peptidoglycan:TLR2 e13:LPS:TLR4 e14:Flagellin e15:Flagellin:TLR5 e16:Diacylated lipoprotein e17:Diacylated lipoprotein:TLR6 e18:Imidazoquinoline e19:Imidazoquinoline: TLR7 e2: e20:R-848 e21:R-848:TLR7 e22:CpGDNA e23:CpGDNA:TLR9 e24:triacylated lipoprotein:TLR1:MyD88 e25:peptidoglycan:TLR2:MyD88 e26:dsRNA:TLR3:MyD88 e27:LPS:TLR4:MyD88 e28:Flagellin:TLR5:MyD88 e29:CpGDNA:TLR9:MyD88 e3: e30:Diacylated lipoprotein:TLR5:MyD88 e31:imidazoquinoline:TLR7:MyD88 e32:R-848:TLR7:MyD88 e33:IRAK-4(active} e34:IRAK1 e35:IRAK1{active} e36:TRAF6{active} e37:NF-kappaB{active} e38:TIRAP:MyD88 e39:TLR4:TIRAP e4: e40:MALP-2 e41:MALP-2:TLR2 e42:MAPK{p} e43:IRF-3:IRF-3 e44:IRF-3:IRF-3 e45:IP-10 e46:GARG-16 e47:IRG-1 e48:TLR3:TRIF e49:TRIF:IRF-3 e5:Triacylated Lipoprotein e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:triacylated lipoprotein:TLR1 e60: e61: e62: e63:Type I IFN e64:Type I IFN e65:TRAM:TIRAP e66:TRAM:TRIF e67:IKK-i e68:IRF-3{p} e69:Ikk-i:TRIF e7: e70:TBK1:TRIF e71:IFN-beta e73:MAPK{active} e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95
Model Detail
347.0, 1171.0
34.0, 34.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p64 p71 p79 p80 p95

p88

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
647.0, 1079.0
34.0, 34.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p90

p51 p57

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
591.0, 1035.0
33.0, 33.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p89

p50 p56

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
621.0, 1149.0
38.0, 38.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
525.0, 1325.0
38.0, 38.0

RANTES

--

G010522

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p81 p82

--

true true true true

csml-variable:Double

m93487

10

false

infinite

0

unit false false false
TRANSFACG010522

--

Go back
640.0, 1212.0
40.0, 40.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p91

p53 p58

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
375.0, 1311.0
34.0, 34.0

IFNA4

--

G022992

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p87

true true true true

csml-variable:Double

m101705

10

false

infinite

0

unit false false false
TRANSFACG022992

--

Go back
205.0, 653.0
38.0, 38.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47 p48 p49 p60 p68 p69 p70 p83 p84 p92 p94

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
356.0, 628.0
32.0, 32.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p39 p40 p41 p42 p43 p44 p45 p46

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1186.0, 914.0
36.0, 36.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50 p56

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
1198.0, 978.0
28.0, 28.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51 p57

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
422.0, 798.0
28.0, 28.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62 p73 p77 p78

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
550.0, 338.0
36.5, 36.5

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12 p13 p14 p15 p16 p17 p18 p19 p50 p51 p52 p53 p54 p68

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1187.0, 1023.0
34.0, 34.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
749.0, 21.0
29.5, 29.5

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
193.0, 1013.0
30.0, 30.0

MAPK

--

MO000016894

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61 p93

true true true true

csml-variable:Double

m1812

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
972.0, 1164.0
32.0, 32.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p78 p79 p81 p83 p86

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
638.0, 126.0
28.0, 28.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p55

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
138.0, 250.0
27.5, 27.5

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false
InterProIPR003016
TRANSPATHMO000019396

--

Go back
182.0, 126.0
27.5, 27.5

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p59

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
433.0, 121.0
30.0, 30.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p72

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1080.0, 188.0
31.0, 31.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
1081.0, 321.0
29.5, 29.5

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
611.0, 883.0
26.0, 26.0

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p92

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
521.0, 21.0
38.0, 38.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
524.0, 744.0
32.0, 32.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54 p55 p69 p75

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
521.0, 421.0
30.0, 30.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p21 p22 p23 p24 p25 p26 p27 p28

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
274.0, 982.0
28.0, 28.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p70 p71 p72 p73 p76 p85 p86 p93

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
949.0, 1093.0
30.0, 30.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p75 p76

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
523.0, 119.0
34.0, 34.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

p13 p94 p95

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
141.0, 485.0
29.0, 29.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
1081.0, 817.0
29.5, 29.5

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
1191.0, 1075.0
26.0, 26.0

IL-12B

--

MO000043607

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53 p58

--

true true true true

csml-variable:Double

m21351

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000043607

--

Go back
64.0, 1336.0
32.0, 32.0

IFNA4

--

MO000061564

cso30:c:Protein

cso30:i:CC_CellComponent

--

p87

--

true true true true

csml-variable:Double

m36461

10

false

infinite

0

unit false false false
TRANSPATHMO000061564

--

Go back
120.75, 103.60405068242082
1011.7345713171857, 1469.0385975525526

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
146.5657484780543, 156.2234699001853
978.2054041513774, 1376.059947375106

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
331.0, 38.0
50.43734230445753, 28.581160639192603

peptidoglycan

--

e11

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
384.5, 97.0
23.340057005042752, 45.17430388072791

peptidoglycan:TLR2

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p12

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
700.5, 101.0
23.25169918877439, 45.00328875246656

LPS:TLR4

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p14 p56 p57 p58 p62 p87 p88 p92 p93

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1194.0, 256.5
36.00724491849466, 22.204467699738377

Flagellin

--

e14

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1084.5, 253.0
23.6730980048235, 45.81889936417451

Flagellin:TLR5

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p15

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1141.5, 407.0
20.59609579392232, 33.399074260414565

Diacylated lipoprotein

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1081.5, 375.0
21.871957903968426, 42.332821749616315

Diacylated lipoprotein:TLR6

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p6

p16

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1191.0, 498.0
50.15979814970564, 28.423885618166526

Imidazoquinoline

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p7 p9

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1079.5, 519.0
25.89563692172769, 50.1205875904407

Imidazoquinoline: TLR7

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p7

p18

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
120.75, 103.60405068242082
1011.7345713171857, 1469.0385975525526

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1177.0, 857.0
53.64171572750209, 30.396972245584543

R-848

--

e20

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p9

p8

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1083.5, 663.0
25.909230431922825, 50.14689761017321

R-848:TLR7

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p19

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
49.05809128630699, 352.2821576763485
54.460580912863065, 14.522821576763487

CpGDNA

--

e22

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
143.5, 400.0
24.69940802455602, 47.8053058539794

CpGDNA:TLR9

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p17 p74

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
148.5, 311.0
30.263351073591487, 42.227931730592765

triacylated lipoprotein:TLR1:MyD88

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p21 p30 p39

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
272.5, 103.0
30.263351073591487, 42.227931730592765

peptidoglycan:TLR2:MyD88

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p22 p31 p40

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
584.5, 103.0
30.263351073591487, 42.227931730592765

dsRNA:TLR3:MyD88

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p23 p32 p41

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
936.5, 103.0
30.263351073591487, 42.227931730592765

LPS:TLR4:MyD88

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p24 p33 p42

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1024.5, 123.0
30.263351073591487, 42.227931730592765

Flagellin:TLR5:MyD88

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p25 p34 p43

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
138.5, 564.0
34.05909341163516, 47.52431638832814

CpGDNA:TLR9:MyD88

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p17

p20 p29 p38

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
140.9846914263437, 123.83874210876456
971.2651884644986, 1428.569214699867

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1080.5, 450.0
31.912644521930645, 44.52927142594972

Diacylated lipoprotein:TLR5:MyD88

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p26 p35 p44

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1084.5, 595.0
30.002936318590574, 41.86456230501011

imidazoquinoline:TLR7:MyD88

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

p27 p36 p45

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1081.5, 748.0
28.298403376766377, 39.486144246650746

R-848:TLR7:MyD88

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

p28 p37 p46

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
649.0, 685.0
30.0, 30.0

IRAK-4(active}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20 p21 p22 p23 p24 p25 p26 p27 p28

p49

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
487.0, 468.5
41.44, 31.08

IRAK1

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p29 p30 p31 p32 p33 p34 p35 p36 p37

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
443.0, 592.5
41.44, 31.08

IRAK1{active}

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

p29 p30 p31 p32 p33 p34 p35 p36 p37

p48

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
412.0, 700.0
32.0, 32.0

TRAF6{active}

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38 p39 p40 p41 p42 p43 p44 p45 p46

p47

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
213.0, 853.0
38.0, 38.0

NF-kappaB{active}

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

p47 p48 p49 p60 p68 p69 p70 p83 p84 p92 p94

p89 p90 p91

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
974.5, 831.0
27.85185802366272, 34.10431594734211

TIRAP:MyD88

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
798.5, 124.0
26.74954174304283, 32.754540909848345

TLR4:TIRAP

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p55

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
178.41887056507971, 159.2494521048659
896.3968301870267, 1357.747794707663

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
46.342304457527334, 782.1606391925988
43.17073170731707, 24.46341463414634

MALP-2

--

e40

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p59

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
152.5, 886.0
31.0, 60.0

MALP-2:TLR2

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p59

p60 p61

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
209.0, 1221.0
30.0, 30.0

MAPK{p}

--

e42

cso30:c:Protein

cso30:i:CC_CellComponent

--

p61

--

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
602.5, 796.0
26.333111148141974, 32.244625895684045

IRF-3:IRF-3

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p62

p63

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
428.5, 978.0
22.634227628728542, 27.715380769871686

IRF-3:IRF-3

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63

p64 p65 p66 p67

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
419.0, 1123.0
50.24221453287197, 26.795847750865054

IP-10

--

e45

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p65

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
466.0, 1166.0
52.16262975778547, 27.82006920415225

GARG-16

--

e46

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p66

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
514.0, 1102.0
52.62975778546713, 28.069204152249135

IRG-1

--

e47

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p67

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
139.5, 668.0
32.71021496417264, 40.05332444592568

TLR3:TRIF

--

e48

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p72

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
458.5, 907.0
27.092484585902348, 33.17447092151309

TRIF:IRF-3

--

e49

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p73

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
102.5, 68.0
19.501509358019717, 31.624069229221178

Triacylated Lipoprotein

--

e5

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
263.0, 941.0
561.8330491800778, 509.5208472080039

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
323.6821542876062, 953.0749033520287
328.5206283846268, 493.82718661638154

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
270.32370827609043, 947.8005862563696
547.1856326278976, 495.9196746952642

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
271.3699523155318, 948.8468302958112
545.0931445490144, 493.82718661638154

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
263.0, 941.0
561.8330491800778, 509.5208472080039

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
263.0, 941.0
561.8330491800778, 509.5208472080039

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
271.3699523155318, 948.8468302958112
545.0931445490144, 493.82718661638154

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
673.1276634610622, 1150.248807888297
35.10024191879371, 31.774955842276448

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
581.0581879902118, 1296.7229734101056
99.39318374694115, 89.97698739196785

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
263.0, 941.0
561.8330491800778, 509.5208472080039

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
144.5, 161.0
23.67309800482351, 45.818899364174534

triacylated lipoprotein:TLR1

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p11

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
395.4208884747678, 1167.4268542938162
17.792427140583847, 8.566724178799628

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
394.82674896962726, 1141.8788555727651
60.899299276924204, 109.61873869846352

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
420.37474769067893, 1213.1755961896524
9.506232082251573, 9.506232082251579

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
348.0, 1243.0
48.63321799307959, 25.93771626297578

Type I IFN

--

e63

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p74

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
67.0, 1250.0
21.67072029934518, 50.00935453695042

Type I IFN

--

e64

cso30:c:Protein

cso30:i:CC_Extracellular

--

p74

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
928.5, 1233.0
31.820196633894348, 38.96350608231962

TRAM:TIRAP

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p75

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
848.5, 1273.0
31.583402766205634, 38.673554407598736

TRAM:TRIF

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p76

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
842.0, 1358.5
43.89213121352385, 27.06681424833971

IKK-i

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p77 p80 p82 p84 p85

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
442.0, 862.0
28.0, 28.0

IRF-3{p}

--

e68

cso30:c:Protein

cso30:i:CC_CellComponent

--

p77 p78

--

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
726.5, 1439.0
27.794700883186135, 34.03432761206466

Ikk-i:TRIF

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p85

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
161.9780938627506, 218.14324775800492
745.7606622090838, 1056.7235951597345

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
967.5, 1398.0
27.89268455257456, 34.15430761539743

TBK1:TRIF

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p86

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
53.5, 1030.0
24.31173274300664, 39.42443147514591

IFN-beta

--

e71

cso30:c:Protein

cso30:i:CC_Extracellular

--

p88

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
205.0, 1117.0
30.0, 30.0

MAPK{active}

--

e73

cso30:c:Protein

cso30:i:CC_CellComponent

--

p93

--

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
132.77573879517578, 168.11037273059523
762.781246621952, 1107.5583700950742

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
175.0, 131.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
56.0, 176.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 MO000019396

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m3963*0.1

nodelay

--

true

0

false

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

Go back
72.0, 516.0
23.0, 23.0

p2

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1

m19828*m22*0.1

nodelay

--

true

0

false

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

Go back
246.0, 206.0
27.0, 27.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000016573

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m6*m1572*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
390.0, 194.0
27.0, 27.0

p11

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000016573

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c37 : 1

m12*m1572*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
454.0, 198.0
27.0, 27.0

p11

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000016573

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c38 : 1

m19314*m1572*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
646.0, 194.0
27.0, 27.0

p11

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000016573

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m13*m1572*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
842.0, 218.0
27.0, 27.0

p11

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000016573

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m15*m1572*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
866.0, 366.0
27.0, 27.0

p11

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000016573

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m17*m1572*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
250.0, 422.0
27.0, 27.0

p11

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 MO000016573

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m23*m1572*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
902.0, 534.0
27.0, 27.0

p11

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 MO000016573

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m19*m1572*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
914.0, 670.0
27.0, 27.0

p11

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e21

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m1572*m21*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
236.0, 40.0
23.0, 23.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3964*m11*0.1

nodelay

--

true

0

false

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

Go back
274.0, 506.0
27.0, 27.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000039077 e29

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c57 : 1
stoichiometry:c59 : 1

m17258*m29*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
286.0, 314.0
27.0, 27.0

p20

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e24 MO000039077

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m24*m17258*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
334.0, 226.0
27.0, 27.0

p20

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 MO000039077

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m25*m17258*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
598.0, 218.0
27.0, 27.0

p20

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 MO000039077

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m26*m17258*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
754.0, 274.0
27.0, 27.0

p20

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e27 MO000039077

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m27*m17258*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
946.0, 314.0
27.0, 27.0

p20

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 MO000039077

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m28*m17258*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
826.0, 402.0
27.0, 27.0

p20

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 MO000039077

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m30*m17258*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
838.0, 542.0
27.0, 27.0

p20

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 MO000039077

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m31*m17258*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
886.0, 726.0
27.0, 27.0

p20

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 MO000039077

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m32*m17258*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
298.0, 462.0
27.0, 27.0

p20

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e29 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m29*m34*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
420.0, 28.0
23.0, 23.0

p2

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

Go back
278.0, 358.0
27.0, 27.0

p20

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e24 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m24*m34*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
318.0, 282.0
27.0, 27.0

p20

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m25*m34*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
462.0, 270.0
27.0, 27.0

p20

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m26*m34*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
734.0, 194.0
27.0, 27.0

p20

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e27 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m27*m34*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
802.0, 282.0
27.0, 27.0

p20

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m28*m34*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
766.0, 438.0
27.0, 27.0

p20

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m30*m34*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
854.0, 594.0
27.0, 27.0

p20

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m31*m34*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
866.0, 678.0
27.0, 27.0

p20

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m32*m34*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
238.0, 542.0
27.0, 27.0

p20

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e29 MO000000212

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m29*m183*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
370.0, 438.0
27.0, 27.0

p20

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e24 MO000000212

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m24*m183*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
672.0, 40.0
23.0, 23.0

p2

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

Go back
438.0, 318.0
27.0, 27.0

p20

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 MO000000212

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1

m25*m183*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
550.0, 238.0
27.0, 27.0

p20

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 MO000000212

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m26*m183*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
754.0, 226.0
27.0, 27.0

p20

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e27 MO000000212

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m27*m183*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
898.0, 282.0
27.0, 27.0

p20

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 MO000000212

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1

m28*m183*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
886.0, 478.0
27.0, 27.0

p20

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 MO000000212

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m30*m183*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
902.0, 630.0
27.0, 27.0

p20

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 MO000000212

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m31*m183*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
910.0, 778.0
27.0, 27.0

p20

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 MO000000212

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m32*m183*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
298.0, 642.0
27.0, 27.0

p20

p47

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 MO000000058

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m36*m37*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
310.0, 694.0
27.0, 27.0

p20

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e35 MO000000058

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m35*m37*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
338.0, 722.0
27.0, 27.0

p20

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e33 MO000000058

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c145 : 1
stoichiometry:c146 : 1

m33*m37*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
1176.0, 188.0
23.0, 23.0

p2

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c13 : 1
stoichiometry:c15 : 1

m3966*m14*0.1

nodelay

--

true

0

false

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

Go back
657.0, 805.0
29.0, 29.0

p50

p50

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 MO000016573

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c157 : 1

m93309*m1572*0.1

nodelay

--

true

0

false

PMID: 14698224 Macrophages from MyD88-deficient mice are completely defective in the production of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, and IL-12 p40 in response to bacterial components.

Go back
793.0, 849.0
29.0, 29.0

p50

p51

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 MO000016573

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c152 : 1
stoichiometry:c156 : 1

m93248*m1572*0.1

nodelay

--

true

0

false

PMID: 14698224 Macrophages from MyD88-deficient mice are completely defective in the production of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, and IL-12 p40 in response to bacterial components.

Go back
973.0, 973.0
29.0, 29.0

p50

p52

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010389 MO000016573

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c153 : 1
stoichiometry:c158 : 1

m93364*m1572*0.1

nodelay

--

true

0

false

PMID: 14698224 Macrophages from MyD88-deficient mice are completely defective in the production of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, and IL-12 p40 in response to bacterial components.

Go back
805.0, 957.0
29.0, 29.0

p50

p53

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657 MO000016573

MO000043607

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m93589*m1572*0.1

nodelay

--

true

0

false

PMID: 14698224 Macrophages from MyD88-deficient mice are completely defective in the production of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, and IL-12 p40 in response to bacterial components.

Go back
610.0, 758.0
27.0, 27.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 MO000016573

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m6810*m1572*0.1

nodelay

--

true

0

false

PMID: 14698224 Furthermore, epitope-tagged TIRAP interacted directly with MyD88 and the TIR domain of TLR4 but not TLR9, suggesting that, unlike MyD88 which participates in all of the TLR and IL-1 receptor signaling pathways, TIRAP is an adaptor molecule specific for TLR4 signaling.

Go back
682.0, 218.0
27.0, 27.0

p54

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 MO000019394

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c162 : 1
stoichiometry:c164 : 1

m6810*m3961*0.1

nodelay

--

true

0

false

PMID: 14698224 Furthermore, epitope-tagged TIRAP interacted directly with MyD88 and the TIR domain of TLR4 but not TLR9, suggesting that, unlike MyD88 which participates in all of the TLR and IL-1 receptor signaling pathways, TIRAP is an adaptor molecule specific for TLR4 signaling.

Go back
683.0, 855.0
25.0, 25.0

p56

p56

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e13

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c165 : 1
stoichiometry:c167 : 1

m93309*m13*0.1

nodelay

--

true

0

false

PMID: 14698224 Regarding cytokine production, LPS stimulation of wildtype macrophages resulted in the production of TNF-alpha, IL-6 and IL-12 p40 in a dose-dependent manner, whereas the production of these cytokines was completely abolished in TIRAP-deficient cells.

Go back
809.0, 905.0
29.0, 29.0

p56

p57

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e13

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m93248*m13*0.1

nodelay

--

true

0

false

PMID: 14698224 Regarding cytokine production, LPS stimulation of wildtype macrophages resulted in the production of TNF-alpha, IL-6 and IL-12 p40 in a dose-dependent manner, whereas the production of these cytokines was completely abolished in TIRAP-deficient cells.

Go back
871.0, 1031.0
25.0, 25.0

p56

p58

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657 e13

MO000043607

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c173 : 1
stoichiometry:c172 : 1

m93589*m13*0.1

nodelay

--

true

0

false

PMID: 14698224 Regarding cytokine production, LPS stimulation of wildtype macrophages resulted in the production of TNF-alpha, IL-6 and IL-12 p40 in a dose-dependent manner, whereas the production of these cytokines was completely abolished in TIRAP-deficient cells.

Go back
30.0, 646.0
27.0, 27.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e40

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c175 : 1
stoichiometry:c176 : 1

m3964*m41*0.1

nodelay

--

true

0

false

PMID: 14698224 Stimulation with MALP-2, a TLR2 ligand, showed NF-KappaB activation and MAPK phosphorylation in wild-type cells, but these were profoundly inhibited in TIRAP-deficient cells.

Go back
1160.0, 324.0
23.0, 23.0

p2

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e16 MO000019422

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m16*m3987*0.1

nodelay

--

true

0

false

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

Go back
202.0, 742.0
27.0, 27.0

p60

p60

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e41 MO000000058

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c178 : 1
stoichiometry:c179 : 1

m42*m37*0.1

nodelay

--

true

0

false

PMID: 14698224 Stimulation with MALP-2, a TLR2 ligand, showed NF-kappaB activation and MAPK phosphorylation in wild-type cells, but these were profoundly inhibited in TIRAP-deficient cells.

Go back
236.0, 916.0
23.0, 23.0

p61

p61

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e41 MO000016894

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m42*m1812*0.1

nodelay

--

true

0

false

PMID: 14698224 Stimulation with MALP-2, a TLR2 ligand, showed NF-kappaB activation and MAPK phosphorylation in wild-type cells, but these were profoundly inhibited in TIRAP-deficient cells.

Go back
439.0, 739.0
25.0, 25.0

p62

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e13 MO000007694

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m13*m977*0.1

nodelay

--

true

0

false

PMID: 14698224, 11070172, 10607756 IRF3 is a key transcription factor for LPS-mediated expression of IFN-beta and IRGs Activated IRF3 forms a homodimer after LPS stimulation and translocates into the nucleus to switch on the induction of IFN-beta and other IRGs

Go back
567.0, 847.0
25.0, 25.0

p63

p63

cso30:i:ME_Translocation

cso30:i:CC_NuclearEnvelopeLumen

--

e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 14698224, 11070172, 10607756 IRF3 is a key transcription factor for LPS-mediated expression of IFN-beta and IRGs Activated IRF3 forms a homodimer after LPS stimulation and translocates into the nucleus to switch on the induction of IFN-beta and other IRGs

Go back
367.0, 1035.0
25.0, 25.0

p64

p64

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 14698224, 11070172, 10607756 IRF3 is a key transcription factor for LPS-mediated expression of IFN-beta and IRGs Activated IRF3 forms a homodimer after LPS stimulation and translocates into the nucleus to switch on the induction of IFN-beta and other IRGs

Go back
423.0, 1055.0
25.0, 25.0

p64

p65

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 14698224, 11070172, 10607756 IRF3 is a key transcription factor for LPS-mediated expression of IFN-beta and IRGs Activated IRF3 forms a homodimer after LPS stimulation and translocates into the nucleus to switch on the induction of IFN-beta and other IRGs

Go back
475.0, 1047.0
25.0, 25.0

p64

p66

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c193 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 14698224, 11070172, 10607756 IRF3 is a key transcription factor for LPS-mediated expression of IFN-beta and IRGs Activated IRF3 forms a homodimer after LPS stimulation and translocates into the nucleus to switch on the induction of IFN-beta and other IRGs

Go back
547.0, 1043.0
25.0, 25.0

p64

p67

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 14698224, 11070172, 10607756 IRF3 is a key transcription factor for LPS-mediated expression of IFN-beta and IRGs Activated IRF3 forms a homodimer after LPS stimulation and translocates into the nucleus to switch on the induction of IFN-beta and other IRGs

Go back
228.0, 584.0
24.0, 24.0

p68

p68

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016573 MO000000058

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m1572*m37*0.1

nodelay

--

true

0

false

PMID: 14698224 As reported previously, overexpression of MyD88 or TIRAP in 293 cells strongly induced NF-kappaB activation as detected by a luciferase-mediated reporter assay

Go back
344.0, 784.0
24.0, 24.0

p68

p69

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000022528 MO000000058

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c200 : 1
stoichiometry:c201 : 1

m6810*m37*0.1

nodelay

--

true

0

false

PMID: 14698224 As reported previously, overexpression of MyD88 or TIRAP in 293 cells strongly induced NF-kappaB activation as detected by a luciferase-mediated reporter assay

Go back
1156.0, 588.0
23.0, 23.0

p2

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 MO000042126

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m18*m19940*0.1

nodelay

--

true

0

false

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

Go back
318.0, 858.0
27.0, 27.0

p70

p70

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000041125 MO000000058

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c203 : 1
stoichiometry:c204 : 1

m18998*m37*0.1

nodelay

--

true

0

false

PMID: 14698224 Overexpression of TRIF activated NF-kappaB, albeit at a low level compared with MyD88- or TIRAP-induced activation

Go back
323.0, 1095.0
25.0, 25.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041125

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c206 : 1

m18998*0.1

nodelay

--

true

0

false

PMID: 14698224 TRIF overexpression culminated in activation of not only the NF-kappaB-responsive element but also the IFN-beta promoter.

Go back
266.0, 606.0
27.0, 27.0

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000019398

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c208 : 1
stoichiometry:c209 : 1

m18998*m3965*0.1

nodelay

--

true

0

false

PMID: 14698224 Coimmunoprecipitation analysis revealed that TRIF associated with the TIR domain of TLR3, indicating that TRIF may recognize TLR3 through homophilic interaction TRIF interacted with TLR3 through the TIR domain and endogenous IRF3.

Go back
358.0, 822.0
27.0, 27.0

p72

p73

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000007694

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c211 : 1
stoichiometry:c212 : 1

m18998*m977*0.1

nodelay

--

true

0

false

PMID: 14698224 Coimmunoprecipitation analysis revealed that TRIF associated with the TIR domain of TLR3, indicating that TRIF may recognize TLR3 through homophilic interaction TRIF interacted with TLR3 through the TIR domain and endogenous IRF3.

Go back
227.0, 1295.0
25.0, 25.0

p74

p74

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e23 e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c214 : 1
stoichiometry:c215 : 1

m23*m64*0.1

nodelay

--

true

0

false

PMID: 14698224 However, the production of type I interferon from certain cell types is stimulated by activation of TLR9 signaling but not by that of TLR2

Go back
868.0, 1092.0
23.0, 23.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 MO000041132

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c217 : 1
stoichiometry:c218 : 1

m6810*m19005*0.1

nodelay

--

true

0

false

PMID: 14698224 In addition, the latter group found that TRAM/TIRP associated with other TIR domain-containing adaptors, including TIRAP and TRIF, but not with MyD88.

Go back
852.0, 1156.0
23.0, 23.0

p75

p76

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000041132

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c220 : 1
stoichiometry:c221 : 1

m18998*m19005*0.1

nodelay

--

true

0

false

PMID: 14698224 In addition, the latter group found that TRAM/TIRP associated with other TIR domain-containing adaptors, including TIRAP and TRIF, but not with MyD88.

Go back
516.0, 804.0
23.0, 23.0

p77

p77

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e67 MO000007694

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c223 : 1
stoichiometry:c224 : 1

m68*m977*0.1

nodelay

--

true

0

false

PMID: 14698224, 12692549, 12702806 Recently, two groups reported that IKK-I/IKK-¦Å and TBK1/T2K act as molecules for mediating IRF3 phosphorylation

Go back
516.0, 876.0
23.0, 23.0

p77

p78

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000019331 MO000007694

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c226 : 1
stoichiometry:c227 : 1

m3902*m977*0.1

nodelay

--

true

0

false

PMID: 14698224, 12692549, 12702806 Recently, two groups reported that IKK-I/IKK-¦Å and TBK1/T2K act as molecules for mediating IRF3 phosphorylation

Go back
419.0, 1211.0
25.0, 25.0

p79

p79

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000019331

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1

m3902*0.1

nodelay

--

true

0

false

PMID: 14698224, 12692549 Surprisingly, overexpression of both molecules led to strong activation of the IFN-beta and RANTES promoters as well as NF-kappaB

Go back
1212.0, 744.0
23.0, 23.0

p2

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e20 MO000042126

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m20*m19940*0.1

nodelay

--

true

0

false

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

Go back
435.0, 1267.0
25.0, 25.0

p79

p80

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e67

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c231 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 14698224, 12692549 Surprisingly, overexpression of both molecules led to strong activation of the IFN-beta and RANTES promoters as well as NF-kappaB

Go back
607.0, 1279.0
25.0, 25.0

p79

p81

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000019331

G010522

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c232 : 1
stoichiometry:c233 : 1

m3902*0.1

nodelay

--

true

0

false

PMID: 14698224, 12692549 Surprisingly, overexpression of both molecules led to strong activation of the IFN-beta and RANTES promoters as well as NF-kappaB

Go back
619.0, 1347.0
25.0, 25.0

p79

p82

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e67

G010522

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c235 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 14698224, 12692549 Surprisingly, overexpression of both molecules led to strong activation of the IFN-beta and RANTES promoters as well as NF-kappaB

Go back
355.0, 887.0
25.0, 25.0

p83

p83

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 MO000000058

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c237 : 1
stoichiometry:c238 : 1

m3902*m37*0.1

nodelay

--

true

0

false

PMID: 14698224, 12692549 Surprisingly, overexpression of both molecules led to strong activation of the IFN-beta and RANTES promoters as well as NF-kappaB

Go back
331.0, 959.0
25.0, 25.0

p83

p84

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e67 MO000000058

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c240 : 1
stoichiometry:c241 : 1

m68*m37*0.1

nodelay

--

true

0

false

PMID: 14698224, 12692549 Surprisingly, overexpression of both molecules led to strong activation of the IFN-beta and RANTES promoters as well as NF-kappaB

Go back
824.0, 1416.0
23.0, 23.0

p85

p85

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e67

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c242 : 1
stoichiometry:c243 : 1
stoichiometry:c246 : 1

m18998*m68*0.1

nodelay

--

true

0

false

PMID: 14698224, 12692549 TRIF bound to IKKI/ IKK-¦Å and TBK1/T2K through regions other than the TIR domain

Go back
960.0, 1316.0
23.0, 23.0

p85

p86

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000019331

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c245 : 1
stoichiometry:c247 : 1

m18998*m3902*0.1

nodelay

--

true

0

false

PMID: 14698224, 12692549 TRIF bound to IKKI/ IKK-¦Å and TBK1/T2K through regions other than the TIR domain

Go back
247.0, 1359.0
25.0, 25.0

p87

p87

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G022992 e13

MO000061564

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c248 : 1
stoichiometry:c250 : 1
stoichiometry:c249 : 1

m101705*m13*0.1

nodelay

--

true

0

false

PMID: 14698224 Instead, LPS-mediated production of type I interferons, such as IFN-beta and IFN-alpha4, was perturbed in Tyk2-deficient mice.

Go back
243.0, 1079.0
25.0, 25.0

p87

p88

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e13

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c252 : 1
stoichiometry:c253 : 1

m93217*m13*0.1

nodelay

--

true

0

false

PMID: 14698224 Instead, LPS-mediated production of type I interferons, such as IFN-beta and IFN-alpha4, was perturbed in Tyk2-deficient mice.

Go back
523.0, 987.0
25.0, 25.0

p89

p89

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c255 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
1188.0, 676.0
23.0, 23.0

p9

p9

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

e18

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

Go back
591.0, 1099.0
25.0, 25.0

p89

p90

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c256 : 1
stoichiometry:c257 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
471.0, 1231.0
25.0, 25.0

p89

p91

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c259 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

Go back
339.0, 583.0
25.0, 25.0

p92

p92

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e13 MO000000058 MO000022131

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c261 : 1
stoichiometry:c270 : 1
stoichiometry:c262 : 1

m13*m37*m6438*0.1

nodelay

--

true

0

false

PMID: 14698224, 10435584 Although the activation of NF-KappaB and MAPK through almost all of the TLRs is abolished in MyD88-deficient cells, the TLR4 ligand LPS stimulation still activates NF-KappaB and MAPK in MyD88-deficient cells, but with delayed kinetics compared with those of wild-type cells PMID: 14698224 LPS stimulation activated the NF-KappaB responsive reporter in cells transfected with both TLR4 and MD-2,

Go back
255.0, 955.0
25.0, 25.0

p92

p93

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e13 MO000016894 MO000041125

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c264 : 1
stoichiometry:c265 : 1
stoichiometry:c266 : 1

m13*m1812*m18998*0.1

nodelay

--

true

0

false

PMID: 14698224, 10435584 Although the activation of NF-KappaB and MAPK through almost all of the TLRs is abolished in MyD88-deficient cells, the TLR4 ligand LPS stimulation still activates NF-KappaB and MAPK in MyD88-deficient cells, but with delayed kinetics compared with those of wild-type cells

Go back
307.0, 539.0
25.0, 25.0

p94

p94

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000041446 MO000000058

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c267 : 1
stoichiometry:c268 : 1
stoichiometry:c269 : 1

m19314*m37*0.1

nodelay

--

true

0

false

PMID: 14698224, 11607032 TLR3 has also been shown to utilize the MyD88-independent pathway, since poly(I:C)-induced NF-KappaB activation and maturation of dendritic cells were observed normally in MyD88-deficient mice

Go back
435.0, 1179.0
25.0, 25.0

p95

p95

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

MO000041446

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c271 : 1
stoichiometry:c272 : 1

m19314*0.1

nodelay

--

true

0

false

PMID: 14698224, 12054664 293 cells stably transfected with TLR3 showed poly(I:C) stimulation-dependent activation of NF-KappaB and the IFN-beta promoter

Go back
76.10445600046506, 100.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
702.8390123896642, 39.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
528.0, 309.1635295009299

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.98235822601083, 308.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
800.9844206278631, 453.49902628924144

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
528.0, 454.9347299805392

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
491.17565817971456, 459.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
888.995294427932, 608.2743483382134

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
528.0, 491.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 608.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
900.5527339886228, 699.6374626626937

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
528.0, 495.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.0, 70.51485855856117

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
491.84226767639854, 613.5807712332007

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
173.0, 563.5647693945351

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
271.47603797215, 570.6969066611198

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
265.0, 568.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
179.0, 340.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
373.0, 472.9849872259236

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
386.0, 465.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
303.0, 143.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
376.0, 352.74643218486716

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.4948253680913, 345.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.0, 63.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
570.1539663520066, 145.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
380.0, 272.18290568597365

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
435.24203364016597, 265.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
787.7742101675565, 134.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
388.0, 258.7175122869749

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
443.65678586900265, 253.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
929.1515151370236, 162.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
388.0, 309.3367147142699

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
450.0419984351752, 308.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.9593538328169, 474.0

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1194.62816499953, 218.55597437364926

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
388.0, 498.2079635197211

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.23223324887346, 499.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
936.906973581205, 618.0

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
388.0, 644.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.9132562344903, 646.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
944.9249690339478, 770.0

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
388.0, 648.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.9061873786675, 719.2215568482061

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.1057411452476, 666.6753833509902

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
343.50156883886996, 623.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1111.0, 200.3688381328672

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
372.94653367162914, 702.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
243.0, 660.4310835055999

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
241.77320112697302, 669.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
243.0, 679.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
246.91204611469414, 721.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
243.0, 682.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
254.30059105762422, 749.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
613.0, 841.7163360018362

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.0, 375.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
675.0, 884.8086101600229

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1114.1754418849364, 210.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
659.0, 999.6679898188406

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
672.0, 992.814301580089

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
577.0, 375.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.0, 375.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
576.0, 375.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
834.0, 976.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.0, 868.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
686.0, 823.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1002.0, 991.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.0, 762.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1156.0, 354.79072967793434

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
570.0, 375.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
637.0, 775.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
659.0, 154.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
545.0, 252.67394375846607

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.0, 155.95489126182227

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.1804900129883, 146.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
616.0, 887.2194367584729

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
708.0, 870.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
715.0, 146.0

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
838.0, 923.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1111.0, 336.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
679.0, 939.9158269941693

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
680.0, 1060.137249016671

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
896.0, 1046.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
716.0, 146.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
50.247190026165704, 154.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
47.443786966451334, 680.8686389671598

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
50.0, 673.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
177.0, 776.6644108915211

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
217.78057139225098, 691.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
218.0, 769.0

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1109.440446698827, 345.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
184.0, 918.0

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
214.0, 946.4139141457872

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
225.62222285707904, 939.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
460.0654168420641, 146.0

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
440.0, 771.7336418228921

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
464.0, 756.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.7455923043988, 828.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.83002450901733, 872.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
397.89062016604316, 1003.0

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
366.9305765837493, 1060.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1177.846660889655, 526.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
437.3262589561145, 1006.0

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
437.0, 1080.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
450.0, 1006.0

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
488.0, 1072.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.0, 998.0

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
547.4625622833173, 1068.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
258.4567462555225, 369.0

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
228.0, 615.8446454055273

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
233.22847819119102, 608.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
375.8465740016939, 763.0

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
84.95136622435614, 203.34614254052332

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1101.0, 618.6397887097269

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
243.0, 690.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
257.82081001928753, 803.0

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
293.0, 892.5496526468145

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
234.0, 691.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
259.0, 872.0

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
294.0, 1010.0

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.0, 1120.0

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
280.18333292925934, 640.9978990389383

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
287.6242993781095, 151.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
179.03172341702356, 628.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1111.4753747837033, 558.6978209215102

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
295.0, 856.0793457790559

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.48229005965027, 817.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
385.0, 847.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
158.0, 448.0

c213

c213

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
259.43845290457017, 1265.0

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
96.8402447129903, 1278.5907742895922

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.0, 776.0

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
898.9893198795369, 1104.4132406834244

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
885.0, 1115.0

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
302.0, 1000.0

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1201.7434356128128, 526.0

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
881.8762871041653, 1117.0

c220

c220

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
864.0, 1179.0

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
539.1329942768483, 833.8496976800103

c222

c222

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
450.0, 813.0

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.1676940130167, 826.0

c224

c224

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
545.7531423576442, 899.2889472248318

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
450.0, 824.0

c226

c226

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
477.8816940385574, 879.37072939801

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.97480956378246, 1181.0

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
388.07934577905587, 1200.725971462661

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1200.0, 699.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
467.8133273780737, 1284.7181138737126

c230

c230

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
384.4143940870649, 1210.8893409368075

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
639.6563846025418, 1185.0

c232

c232

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
569.6098187424603, 1301.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.9898164372274, 1361.4035260826884

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
570.8754206040678, 1349.4063251078692

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
387.2879825398394, 908.2992893930355

c236

c236

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
236.0, 691.0

c237

c237

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
258.84173195540416, 877.5834266448412

c238

c238

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
362.33425804450775, 985.8864276343346

c239

c239

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1207.0, 774.8911513906571

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
232.0, 691.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
256.98339922956467, 894.3102668162386

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
302.0, 1007.0

c242

c242

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.5777087639997, 1386.0

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
302.0, 1003.0

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
973.8616253494672, 1196.0

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.6921915811266, 1432.0

c246

c246

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
973.0, 1339.0

c247

c247

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
279.59680967328194, 1334.0

c248

c248

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
103.94977739241796, 1354.895008050802

c249

c249

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1111.0, 767.0858833110734

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.722488800231, 146.0

c250

c250

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
273.98763048928566, 1108.305495370253

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
265.41235091822966, 146.0

c252

c252

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
85.81612609127994, 1054.7053366017337

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
251.0, 880.0

c254

c254

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
548.0, 1009.0

c255

c255

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
251.0, 884.0

c256

c256

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
616.0, 1102.9990241521741

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
245.0, 891.0

c258

c258

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
496.0, 1233.5542207894264

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1116.0569260566433, 698.7682614865571

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
366.8548153975259, 139.0

c260

c260

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
243.0, 608.0843100332435

c261

c261

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
243.20184069957602, 608.0

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
278.7274138682504, 146.0

c263

c263

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
223.0, 985.6568542494924

c264

c264

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.64990554975276, 974.5098677696539

c265

c265

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
226.24215237830634, 980.0

c266

c266

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
330.7380493899304, 153.0

c267

c267

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
239.0, 570.2537999557666

c268

c268

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
239.13427024647592, 564.0

c269

c269

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
102.44994223764603, 506.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.36956483049005, 613.9302422826697

c270

c270

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
449.69906998171876, 153.0

c271

c271

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
388.99451867013414, 1189.296093284079

c272

c272

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
76.0, 367.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
92.0, 448.5455335748853

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
79.0, 185.3632612873492

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
168.0, 188.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.32135058332136, 229.22456596088523

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
184.19409903942767, 233.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
398.0, 142.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
422.93968667858485, 225.35911580022693

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.5268621723705, 153.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
481.58380379521583, 231.5565801121442

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
309.4795369723442, 139.69207849721474

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
481.0, 138.42279864409215

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
673.2519285685115, 143.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
204.0, 69.8982868839523

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
579.0, 227.78724345206274

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.0, 130.21314898004775

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
876.8662560398757, 235.45671408145847

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.0, 241.1687288914772

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
869.0, 154.46635547894303

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
168.0, 425.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
284.7354940600272, 361.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
177.61788654201956, 449.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
900.9781420356537, 381.5909734841225

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.0, 357.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.0, 52.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.0, 385.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
936.9971945819503, 544.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.0, 366.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
929.0, 553.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
587.0, 373.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.9968720980183, 684.2236887300145

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 691.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
173.0, 530.6619661557055

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
308.57208150542834, 441.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
301.0, 526.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
259.0, 57.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
179.0, 328.29885666707884

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
320.27692927208295, 337.32359750407636

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.0, 341.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
299.0, 145.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
365.55308456467384, 258.7587543633655

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.0, 253.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
602.0, 145.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
542.0, 252.50455861763058

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
613.0, 245.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
786.991972499923, 138.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
451.0, 40.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
551.0, 301.2906986696185

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
669.9592898756969, 301.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
969.1988039844687, 165.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
551.0, 333.9633749357631

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.9842388029148, 341.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
860.8143047067587, 420.71366331288567

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
551.0, 417.5225182481238

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.2208851533543, 429.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.7774910545393, 560.8736682995027

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
551.0, 442.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
435.35171052088674, 58.884978038506134

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.3469229432658, 567.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.9205305721302, 743.1248090753321

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
551.0, 449.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
686.8880399010758, 704.333726553322

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
173.0, 490.6744378067606

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
332.99451867013414, 477.29609328407906

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
325.0, 487.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
179.0, 337.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
312.10793806975215, 382.67113284921265

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
301.0, 385.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
443.0, 50.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
293.0, 145.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
349.4520240674143, 314.85452248849856

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.0, 309.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
491.91152490811936, 144.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
479.2854048166537, 304.89605815944407

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
465.2970922219909, 297.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
768.3895745392846, 130.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.0, 227.03265276709044

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
479.629976047529, 221.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
835.6354954168422, 155.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back