Original Literature | Model OverView |
---|---|
Publication
Title
Receptor tyrosine kinases and the regulation of macrophage activation.
Affiliation
Department of Veterinary Science, The Pennsylvania State University, UniversityPark, PA 16802-3500, USA. phc7@psu.edu
Abstract
PMID
14726496
|
Entity
IL-12 p40
--
G010657
cso30:c:mRNA
cso30:i:CC_CellComponent
--
csml-variable:Double
m93589
10
infinite
0
TRANSFAC | G010657 |
--
RTK ligan: RTK
--
MO000000013
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m45
10
infinite
0
TRANSPATH | MO000000013 |
--
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m37
10
infinite
0
TRANSPATH | MO000000058 |
--
IkappaB
--
MO000000215
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m186
10
infinite
0
TRANSPATH | MO000000215 |
--
TNF-alpha
--
MO000000289
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m230
10
infinite
0
InterPro | IPR003636 |
TRANSPATH | MO000000289 |
--
IFNgamma: IFN gamma receptor
--
MO000016665
cso30:c:Complex
cso30:i:CC_CellComponent
--
csml-variable:Double
m1639
10
infinite
0
InterPro | IPR002069 |
TRANSPATH | MO000016665 |
--
IL-4: IL-4R
--
MO000017053
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1947
10
infinite
0
InterPro | IPR001325 |
TRANSPATH | MO000017053 |
--
PI-3K
--
MO000017257
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2113
10
infinite
0
InterPro | IPR002420 |
TRANSPATH | MO000017257 |
--
IL-12
--
MO000017265
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2121
10
infinite
0
TRANSPATH | MO000017265 |
--
FGF-2: FGF-2 receptor
--
MO000019755
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m4286
10
infinite
0
InterPro | IPR008996 |
TRANSPATH | MO000019755 |
--
STAT3{p}
--
MO000021607
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m5950
10
infinite
0
TRANSPATH | MO000021607 |
--
L-arginine
--
MO000038797
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m16983
10
infinite
0
DIP | 232 |
TRANSPATH | MO000038797 |
--
prostaglandin E synthase 2
--
MO000064501
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m39373
10
infinite
0
TRANSPATH | MO000064501 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
ligand: Gas6
--
e11
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m11
0
infinite
0
--
ligand: protein S
--
e12
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m12
0
infinite
0
--
ligand: STK
--
e13
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m13
0
infinite
0
--
InlB
--
e15
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m15
0
infinite
0
--
InlB: Met
--
e16
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m16
0
infinite
0
--
CR3 {activated}
--
e18
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m18
10
infinite
0
TRANSPATH | MO000017034 |
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
C3bi: CR3 {activated}
--
e20
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m20
0
infinite
0
--
ICAM-1: CR3 {activated}
--
e21
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m21
0
infinite
0
--
csml-variable:Double
m22
0
infinite
0
--
LPS: CR3 {activated}
--
e23
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m23
0
infinite
0
--
zymosan: CR3 {activated}
--
e24
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m24
0
infinite
0
--
scavenger receptor A
--
e25
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m25
10
infinite
0
Affymetrix | 208422_at |
Ensembl | ENSG00000038945 |
HGNC | MSR1 |
InterPro | IPR003543 |
OMIM | 153622 |
PIR | A38415 |
PROSITE | PS00420 |
Proteome | HumanPSD/MSR1 |
RefSeq | NM_002445 |
TRANSPATH | MO000116148 |
Unigene | Hs.147635 |
UniProt | P21757 |
--
csml-variable:Double
m26
10
infinite
0
Affymetrix | 1425434_a_at |
Ensembl | ENSMUSG00000025044 |
MGD | Msr1 |
Proteome | HumanPSD/Msr1 |
RefSeq | NM_031195 |
TRANSFAC | G006438 |
Unigene | Mm.1227 |
--
lipid A
--
e27
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m27
0
infinite
0
--
lipoteichoic acid
--
e28
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m28
0
infinite
0
--
lipid A: scavenger receptor A
--
e29
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
lipoteichoic acid: scavenger receptor A
--
e30
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m30
0
infinite
0
--
lipoprotein
--
e31
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m31
0
infinite
0
--
lipoprotein: scavenger receptor A
--
e32
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m32
0
infinite
0
--
MSP: STK
--
e35
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m35
0
infinite
0
--
cyclooxygenase-2
--
e36
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m36
0
infinite
0
--
NF-kappaB {activated}
--
e37
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m38
10
infinite
0
TRANSPATH | MO000000058 |
--
phosphatidyl serine
--
e38
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m39
0
infinite
0
--
phosphatidyl serine: Gas6
--
e39
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m40
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
csml-variable:Double
m42
10
infinite
0
Affymetrix | 100962_at |
Ensembl | ENSMUSG00000002147 |
InterPro | IPR008967 |
MGD | MGI:103034 |
PROSITE | PS50001 |
Proteome | HumanPSD/Stat6 |
RefSeq | NM_009284 |
TRANSFAC | T08683 |
TRANSPATH | MO000079083 |
Unigene | Mm.121721 |
UniProt | P52633 |
--
STAT6 {activated}
--
e42
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m43
10
infinite
0
Affymetrix | 100962_at |
Ensembl | ENSMUSG00000002147 |
InterPro | IPR008967 |
MGD | MGI:103034 |
PROSITE | PS50001 |
Proteome | HumanPSD/Stat6 |
RefSeq | NM_009284 |
TRANSFAC | T08683 |
TRANSPATH | MO000079083 |
Unigene | Mm.121721 |
UniProt | P52633 |
--
SOCS
--
e44
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m46
0
infinite
0
--
IkappaB {p}
--
e45
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m47
0
infinite
0
--
IkappaB
--
e46
cso30:c:mRNA
cso30:i:CC_Nucleolus
--
--
csml-variable:Double
m48
0
infinite
0
--
IFNgamma receptor
--
e47
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m63
0
infinite
0
--
IL-4R
--
e48
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m64
0
infinite
0
--
IL-4
--
e49
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m65
0
infinite
0
--
IFN gamma
--
e5
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m49
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
ligand
--
e6
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
FGF-2 receptor
--
e63
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m66
0
infinite
0
--
FGF-2
--
e64
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m67
0
infinite
0
--
RTK ligand
--
e65
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m68
0
infinite
0
--
RTK
--
e66
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m69
0
infinite
0
--
Th2 cytokines
--
e67
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m70
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1
m63*m49*0.1
nodelay
--
0
PMID: 14726496 Pretreatment of macrophages with MSP also results in the inhibition of major histcompatibility complex (MHC) class II expression in response to IFN-gamma and IL-4 and reduced Th1/Th2 differentiation under polarizing conditions in vitro.
p10
p10
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c28 : 1
m18*m22*0.1
nodelay
--
0
PMID: 14726496 signaling through the STK receptor regulates the activation of the alphaMbeta2 integrin, complement receptor 3 (CR3), which recognizes a variety of exogenous and endogenous ligands, including C3bi, intercellular adhesion molecule-1 (ICAM-1), LPS, and zymosan.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c29 : 1
m35*0.1
nodelay
--
0
PMID: 14726496, 11777982 MSP stimulation of primary peritoneal macrophages induces the expression of scavenger receptor A, which recognizes the exogenous ligands lipid A and lipoteichoic acid as well as oxidized low-density lipoprotein and apoptotic cells, resulting in enhanced uptake of acetylated LDL by these cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c34 : 1
m27*m25*0.1
nodelay
--
0
PMID: 14726496, 11777982 MSP stimulation of primary peritoneal macrophages induces the expression of scavenger receptor A, which recognizes the exogenous ligands lipid A and lipoteichoic acid as well as oxidized low-density lipoprotein and apoptotic cells, resulting in enhanced uptake of acetylated LDL by these cells.
p13
p13
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c35 : 1
m28*m25*0.1
nodelay
--
0
PMID: 14726496, 11777982 MSP stimulation of primary peritoneal macrophages induces the expression of scavenger receptor A, which recognizes the exogenous ligands lipid A and lipoteichoic acid as well as oxidized low-density lipoprotein and apoptotic cells, resulting in enhanced uptake of acetylated LDL by these cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1
m25*m31*0.1
nodelay
--
0
PMID: 14726496, 11777982 MSP stimulation of primary peritoneal macrophages induces the expression of scavenger receptor A, which recognizes the exogenous ligands lipid A and lipoteichoic acid as well as oxidized low-density lipoprotein and apoptotic cells, resulting in enhanced uptake of acetylated LDL by these cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c40 : 1
1.0*0.1
nodelay
--
0
PMID: 14726496 Although the Tyro3 family of receptors is reported to be widely expressed by monocytes and their derivatives, expression of the STK receptor by monocyte/macrophage populations is highly regulated. PMID: 14726496, 10725742 LPS stimulation of macrophages in vitro or in vivo inhibits expression of STK.
p16
p16
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c44 : 1
stoichiometry:c43 : 1
m74475*m13*0.1
nodelay
--
0
PMID: 14726496, 11141491 STK may enhance clearance of Listeria through the activation of other PRRs, such as R-A, which has been shown to be critical in the innate response to infection with Listeria.
p17
p17
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1
m14*m1781*0.1
nodelay
--
0
PMID: 14726496 MSP, the ligand for STK, was originally isolated from serum as a result of its ability to induce chemotaxis and complement-mediated phagocytosis by primary peritoneal macrophages.
p18
p18
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c119 : 1
stoichiometry:c127 : 1
stoichiometry:c48 : 1
m155666*0.1
nodelay
--
0
PMID: 14726496, 7514598, 10586055, 12177064 MSP stimulation of primary peritoneal macrophages inhibits the production of nitric oxide (NO) and prostaglandin E2 in response to proinflammatory cytokines and LPS, as a result of an inhibition of the expression of inducible NO synthase (iNOS) and cyclooxygenase- 2, respectively. PMID: 14726496, 10229863 Conversely, PI-3K has been shown to be a negative regulator of iNOS expression in macrophages through sustained activation of NF-kappaB.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c52 : 1
m36*0.1
nodelay
--
0
PMID: 14726496, 7514598, 10586055, 12177064 MSP stimulation of primary peritoneal macrophages inhibits the production of nitric oxide (NO) and prostaglandin E2 in response to proinflammatory cytokines and LPS, as a result of an inhibition of the expression of inducible NO synthase (iNOS) and cyclooxygenase- 2, respectively.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c3 : 1
stoichiometry:c4 : 1
m6039*m6*0.1
nodelay
--
0
PMID: 14726496, 7867073, 7854420, 7939629 Consistent with the activation of nearly all RTKs, the ligands for the Tyro3 family of RTKs (Gas6 and protein S) and STK [macrophage-stimulating protein (MSP)] bind to the extracellular domain of their respective receptors, resulting in the up-regulation of kinase activity.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
m93479*0.1
nodelay
--
0
PMID: 14726496, 7514598, 10586055, 12177064 MSP stimulation of primary peritoneal macrophages inhibits the production of nitric oxide (NO) and prostaglandin E2 in response to proinflammatory cytokines and LPS, as a result of an inhibition of the expression of inducible NO synthase (iNOS) and cyclooxygenase- 2, respectively.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c51 : 1
1.0*0.1
nodelay
--
0
PMID: 14726496, 7514598, 10586055, 12177064 MSP stimulation of primary peritoneal macrophages inhibits the production of nitric oxide (NO) and prostaglandin E2 in response to proinflammatory cytokines and LPS, as a result of an inhibition of the expression of inducible NO synthase (iNOS) and cyclooxygenase- 2, respectively.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c56 : 1
m23*0.1
nodelay
--
0
PMID: 14726496, 10092806 A deletion in the tyrosine kinase domain of the closely related Mer RTK also results in enhanced sensitivity to endotoxic shock, and macrophages from these animals produce elevated levels of tumor necrosis factor alpha (TNF-alpha) and display increased activation of NF-kappaB in response to stimulation with LPS.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c57 : 1
m93309*0.1
nodelay
--
0
PMID: 14726496, 10092806 A deletion in the tyrosine kinase domain of the closely related Mer RTK also results in enhanced sensitivity to endotoxic shock, and macrophages from these animals produce elevated levels of tumor necrosis factor alpha (TNF-alpha) and display increased activation of NF-kappaB in response to stimulation with LPS.
p24
p24
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c60 : 1
stoichiometry:c118 : 1
stoichiometry:c62 : 1
m37*m23*m47*0.1
nodelay
--
0
PMID: 14726496, 10092806 A deletion in the tyrosine kinase domain of the closely related Mer RTK also results in enhanced sensitivity to endotoxic shock, and macrophages from these animals produce elevated levels of tumor necrosis factor alpha (TNF-alpha) and display increased activation of NF-kappaB in response to stimulation with LPS. PMID: 14726496, 10669740, 10485711 RTK signaling has been shown to activate NF-kappaB signaling in several cell types through the PI-3K- and Akt-dependent phosphorylation of IkappaB kinase.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1
m39*m6039*0.1
nodelay
--
0
PMID: 14726496, 11346799 In addition, Tyro3 receptors play a direct role in the recognition of apoptotic cells through the interaction of Gas6 with phosphatidyl serine on the surface of apoptotic cells, and macrophages from Mer knockout (KO) mice are defective in the clearance of apoptotic thymocytes.
p26
p26
cso30:i:ME_Oxidation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1
m5576*m16983*0.1
nodelay
--
0
PMID: 14726496 Although proinflammatory cytokines and LPS induce expression of iNOS, resulting in the metabolism of arginine to NO, T helper cell type 2 (Th2) cytokines induce expression of arginase, resulting in the production of ornithine.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c75 : 1
m23*0.1
nodelay
--
0
PMID: 14726496 MSP stimulation of the STK receptor inhibits iNOS expression in response to interferon-gamma (IFN-gamma) and LPS and induces the expression of arginase, thus favoring the metabolism of arginine to ornithine.
p28
p28
cso30:i:ME_Oxidation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c72 : 1
stoichiometry:c74 : 1
m16983*m63554*0.1
nodelay
--
0
PMID: 14726496 Although proinflammatory cytokines and LPS induce expression of iNOS, resulting in the metabolism of arginine to NO, T helper cell type 2 (Th2) cytokines induce expression of arginase, resulting in the production of ornithine.
p29
p29
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c88 : 1
stoichiometry:c121 : 1
stoichiometry:c85 : 1
m23*0.1
nodelay
--
0
PMID: 14726496 pretreatment of primary peritoneal macrophages with MSP for 2?4 h results in the complete inhibition of IL-12 production in response to IFN-gamma and LPS as a result of the inhibition of IL-12 p40 expression. PMID: 14726496, 12154357 recent studies have demonstrated that PI-3K negatively regulates the production of IL-12 by dendritic cells and Th1 responses in vivo.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c5 : 1
stoichiometry:c7 : 1
m6*m37009*0.1
nodelay
--
0
PMID: 14726496, 7867073, 7854420, 7939629 Consistent with the activation of nearly all RTKs, the ligands for the Tyro3 family of RTKs (Gas6 and protein S) and STK [macrophage-stimulating protein (MSP)] bind to the extracellular domain of their respective receptors, resulting in the up-regulation of kinase activity.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c76 : 1
m1639*0.1
nodelay
--
0
PMID: 14726496 MSP stimulation of the STK receptor inhibits iNOS expression in response to interferon-gamma (IFN-gamma) and LPS and induces the expression of arginase, thus favoring the metabolism of arginine to ornithine.
p31
p31
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c71 : 1
stoichiometry:c79 : 1
m43*m2113*0.1
nodelay
--
0
PMID: 14726496, 11160269 IL-4, a potent inhibitor of NO production, accomplishes this task by up-regulating arginase expression through the activation of signal transducer and activator of transcription (Stat)6 and limiting the amount of L-arginine available to iNOS. PMID: 14726496 The ability of STK and PI-3K to induce arginase I expression in resident macrophages suggests a potential dual role for RTK signaling in limiting tissue-destructive inflammation and pro-moting the wound-healing process by tipping the balance of arginine metabolism in macrophages.
p32
p32
cso30:i:ME_UnknownActivation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c80 : 1
stoichiometry:c83 : 1
stoichiometry:c81 : 1
m1947*m42*m35*0.1
nodelay
--
0
PMID: 14726496, 11160269 IL-4, a potent inhibitor of NO production, accomplishes this task by up-regulating arginase expression through the activation of signal transducer and activator of transcription (Stat)6 and limiting the amount of L-arginine available to iNOS. PMID: 14726496, 1777982 We have shown that MSP induces expression of arginase I in primary peritoneal macrophages and cooperates with IL-4 to enhance arginase activity in a Stat6-dependent manner.
p33
p33
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c87 : 1
stoichiometry:c120 : 1
stoichiometry:c84 : 1
m1639*0.1
nodelay
--
0
PMID: 14726496 pretreatment of primary peritoneal macrophages with MSP for 2?4 h results in the complete inhibition of IL-12 production in response to IFN-gamma and LPS as a result of the inhibition of IL-12 p40 expression. PMID: 14726496 This inhibition appears to result from a block in Stat1 tyrosine phosphorylation and IFN consensus sequence-binding protein up-regulation induced by IFN-gamma. PMID: 14726496, 12154357 recent studies have demonstrated that PI-3K negatively regulates the production of IL-12 by dendritic cells and Th1 responses in vivo.
p34
p34
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c91 : 1
stoichiometry:c90 : 1
m1639*0.1
nodelay
--
0
PMID: 14726496 Pretreatment of macrophages with MSP also results in the inhibition of major histcompatibility complex (MHC) class II expression in response to IFN-gamma and IL-4 and reduced Th1/Th2 differentiation under polarizing conditions in vitro.
p35
p35
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c92 : 1
m1947*0.1
nodelay
--
0
PMID: 14726496 Pretreatment of macrophages with MSP also results in the inhibition of major histcompatibility complex (MHC) class II expression in response to IFN-gamma and IL-4 and reduced Th1/Th2 differentiation under polarizing conditions in vitro.
p36
p36
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c110 : 1
stoichiometry:c97 : 1
m1357*m1639*0.1
nodelay
--
0
PMID: 14726496 This inhibition appears to result from a block in Stat1 tyrosine phosphorylation and IFN consensus sequence-binding protein up-regulation induced by IFN-gamma. PMID: 14726496 RTK signaling could ultimately inhibit LPS-induced NF-kappaB activation and IFN-gamma-induced Stat1 tyrosine phosphorylation through the induction of classical negative-feedback pathways.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c99 : 1
m23*0.1
nodelay
--
0
PMID: 14726496, 11452127 macrophages and dendritic cells from triple mutant mice for the RTKs Tyro3, Axl, and Mer express elevated levels of MHC class II and the costimulatory molecule B7-2 in response to LPS and produce increased levels of IL-12.
p38
p38
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c103 : 1
stoichiometry:c102 : 1
m1360*m2103*0.1
nodelay
--
0
PMID: 14726496 IL-10, a potent inhibitor of classical activation, induces Stat3 phosphorylation.
p39
p39
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c104 : 1
m5950*0.1
nodelay
--
0
PMID: 14726496, 12538698, 10029571 IL-10 induces the expression of SOCS1 and SOCS3 in a Stat3-dependent manner.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c8 : 1
m14*m6*0.1
nodelay
--
0
PMID: 14726496, 7867073, 7854420, 7939629 Consistent with the activation of nearly all RTKs, the ligands for the Tyro3 family of RTKs (Gas6 and protein S) and STK [macrophage-stimulating protein (MSP)] bind to the extracellular domain of their respective receptors, resulting in the up-regulation of kinase activity.
p40
p40
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c105 : 1
m5950*0.1
nodelay
--
0
PMID: 14726496, 12538698, 10029571 IL-10 induces the expression of SOCS1 and SOCS3 in a Stat3-dependent manner.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c108 : 1
m23*0.1
nodelay
--
0
PMID: 14726496 the induction of IL-10 in response to LPS may provide an important negative-feedback mechanism for limiting the extent and/or duration of this response.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c111 : 1
m45*0.1
nodelay
--
0
PMID: 14726496 Several RTKs have also been shown to induce the expression of SOCS proteins, suggesting the possibility that RTK signaling could regulate macrophage activation through the induction of SOCS1 and SOCS3.
p43
p43
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c1 : 1
stoichiometry:c114 : 1
m186*m5*0.1
nodelay
--
0
PMID: 14726496, 10669740, 10485711 RTK signaling has been shown to activate NF-kappaB signaling in several cell types through the PI-3K- and Akt-dependent phosphorylation of IkappaB kinase.
p44
p44
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c117 : 1
stoichiometry:c116 : 1
m186*m2113*0.1
nodelay
--
0
PMID: 14726496, 10669740, 10485711 RTK signaling has been shown to activate NF-kappaB signaling in several cell types through the PI-3K- and Akt-dependent phosphorylation of IkappaB kinase.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c122 : 1
m38*0.1
nodelay
--
0
PMID: 14726496 Twist 1 and twist 2 are basichelix-loop-helix transcription factors that are up-regulated in response to NF-kappaB. PMID: 14726496 Negative-feedback inhibition of the NF-kappaB signaling pathway has also been demonstrated through the up-regulation of IkappaB and more recently, the p65-dependent xpression of twist proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c123 : 1
m38*0.1
nodelay
--
0
PMID: 14726496 Twist 1 and twist 2 are basichelix-loop-helix transcription factors that are up-regulated in response to NF-kappaB. PMID: 14726496 Negative-feedback inhibition of the NF-kappaB signaling pathway has also been demonstrated through the up-regulation of IkappaB and more recently, the p65-dependent xpression of twist proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
m38*0.1
nodelay
--
0
PMID: 14726496 Negative-feedback inhibition of the NF-kappaB signaling pathway has also been demonstrated through the up-regulation of IkappaB and more recently, the p65-dependent xpression of twist proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c130 : 1
m16*0.1
nodelay
--
0
PMID: 14726496, 10825239, 11169739 It is interesting that the Met RTK has been shown to induce muscle differentiation through the upregulation of twist 1 expression, and fibroblast growth factor 2 induces expression of twist 1 in osteoblasts.
p49
p49
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleolus
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c132 : 1
m4286*0.1
nodelay
--
0
PMID: 14726496, 10825239, 11169739 It is interesting that the Met RTK has been shown to induce muscle differentiation through the upregulation of twist 1 expression, and fibroblast growth factor 2 induces expression of twist 1 in osteoblasts.PMID: 14726496, 10825239, 11169739
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1
m15*m3463*0.1
nodelay
--
0
PMID: 14726496, 11081636 Listeria monocytogenes has been shown to gain entry into hepatocytes through the interaction of InlB with the Met receptor.
p50
p50
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
m2121*0.1
nodelay
--
0
PMID: 14726496 IL-12 has been shown to play an important role in sustaining autoimmunity in several mouse models through its ability to mediate the production of IFN-gamma and favor a Th1 response.
p51
p51
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c138 : 1
stoichiometry:c137 : 1
m2121*m93423*0.1
nodelay
--
0
PMID: 14726496 IL-12 has been shown to play an important role in sustaining autoimmunity in several mouse models through its ability to mediate the production of IFN-gamma and favor a Th1 response.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1
m65*m64*0.1
nodelay
--
0
PMID: 14726496, 11160269 IL-4, a potent inhibitor of NO production, accomplishes this task by up-regulating arginase expression through the activation of signal transducer and activator of transcription (Stat)6 and limiting the amount of L-arginine available to iNOS.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1
m66*m67*0.1
nodelay
--
0
PMID: 14726496, 10825239, 11169739 It is interesting that the Met RTK has been shown to induce muscle differentiation through the upregulation of twist 1 expression, and fibroblast growth factor 2 induces expression of twist 1 in osteoblasts.PMID: 14726496, 10825239, 11169739
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1
m69*m68*0.1
nodelay
--
0
PMID: 14726496 Several RTKs have also been shown to induce the expression of SOCS proteins, suggesting the possibility that RTK signaling could regulate macrophage activation through the induction of SOCS1 and SOCS3.
p33
p55
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c131 : 1
stoichiometry:c98 : 1
m4238*0.1
nodelay
--
0
PMID: 14726496 pretreatment of primary peritoneal macrophages with MSP for 2?4 h results in the complete inhibition of IL-12 production in response to IFN-gamma and LPS as a result of the inhibition of IL-12 p40 expression. PMID: 14726496 This inhibition appears to result from a block in Stat1 tyrosine phosphorylation and IFN consensus sequence-binding protein up-regulation induced by IFN-gamma. PMID: 14726496, 12154357 recent studies have demonstrated that PI-3K negatively regulates the production of IL-12 by dendritic cells and Th1 responses in vivo.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c152 : 1
m70*0.1
nodelay
--
0
PMID: 14726496 Although proinflammatory cytokines and LPS induce expression of iNOS, resulting in the metabolism of arginine to NO, T helper cell type 2 (Th2) cytokines induce expression of arginase, resulting in the production of ornithine.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1
m17*m13*0.1
nodelay
--
0
PMID: 14726496 signaling through the STK receptor regulates the activation of the alphaMbeta2 integrin, complement receptor 3 (CR3), which recognizes a variety of exogenous and endogenous ligands, including C3bi, intercellular adhesion molecule-1 (ICAM-1), LPS, and zymosan.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1
m18*m19*0.1
nodelay
--
0
PMID: 14726496 signaling through the STK receptor regulates the activation of the alphaMbeta2 integrin, complement receptor 3 (CR3), which recognizes a variety of exogenous and endogenous ligands, including C3bi, intercellular adhesion molecule-1 (ICAM-1), LPS, and zymosan.
p8
p8
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1
m18*m242*0.1
nodelay
--
0
PMID: 14726496 signaling through the STK receptor regulates the activation of the alphaMbeta2 integrin, complement receptor 3 (CR3), which recognizes a variety of exogenous and endogenous ligands, including C3bi, intercellular adhesion molecule-1 (ICAM-1), LPS, and zymosan.
p9
p9
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c27 : 1
m18*m155666*0.1
nodelay
--
0
PMID: 14726496 signaling through the STK receptor regulates the activation of the alphaMbeta2 integrin, complement receptor 3 (CR3), which recognizes a variety of exogenous and endogenous ligands, including C3bi, intercellular adhesion molecule-1 (ICAM-1), LPS, and zymosan.
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--