PMID: 15049289 In the prototypical pathway, NF-KappaB is retained in the cytoplasm by IKappaB inhibitor proteins.

PMID: 15049289 A wide variety of stimuli activate NF-kB, including mitogens for antigen receptors, proinflammatory cytokines and the bacterial product lipopolysaccharide (LPS).

PMID: 15049289 A wide variety of stimuli activate NF-kB, including mitogens for antigen receptors, proinflammatory cytokines and the bacterial product lipopolysaccharide (LPS). PMID: 15049289, 12910267 Bcl10 is required for full LPS activation of NF-kB in MZ B cells but not in follicular B cells.

PMID: 15049289 A wide variety of stimuli activate NF-kB, including mitogens for antigen receptors, proinflammatory cytokines and the bacterial product lipopolysaccharide (LPS).

PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells. PMID: 15049289, 12154360, 12867038 Bcl10 is recruited to the membrane by dimerization with the CARD domain of the hematopoietic-specific membrane-associated guanylate kinase (MAGUK) protein Carma1 (CARD11 or Bimp3)

PMID: 15049289, 12909454 Carma1 is lipid raft-associated, co-localizes with the T-cell receptor (TCR) in T cells and is required for TCR-activation of NF-KappaB

PMID: 15049289, 12909454 Carma1 is lipid raft-associated, co-localizes with the T-cell receptor (TCR) in T cells and is required for TCR-activation of NF-KappaB.

PMID: 15049289, 10880523 These results suggest that Bcl10 might have a specific role downstream of LPS receptor signaling, which on mature B cells includes Toll-like receptor 4 (TLR4) and RP105 (CD180)

PMID: 15049289 Stimulation of the BCR activates calcium and mitogen-activated protein kinase (MAPK) signaling as well as Carma1, Bcl10 and mucosa-associated lymphoma tissue 1 (MALT1) upstream of IkB kinase (IKK) and NF-KappaB. PMID: 15049289 BCR activation of Carma1 might be mediated by protein kinase Cb (PKCb

PMID: 15049289 Stimulation of the BCR activates calcium and mitogen-activated protein kinase (MAPK) signaling as well as Carma1, Bcl10 and mucosa-associated lymphoma tissue 1 (MALT1) upstream of IkB kinase (IKK) and NF-KappaB.

PMID: 15049289 Stimulation of the BCR activates calcium and mitogen-activated protein kinase (MAPK) signaling as well as Carma1, Bcl10 and mucosa-associated lymphoma tissue 1 (MALT1) upstream of IkB kinase (IKK) and NF-KappaB.

PMID: 15049289 Release of NF-kB is triggered by phosphorylation of IkB by the IkB kinase (IKK) kinase complex, leading to ubiquitin-mediated degradation of IkB and entry of NF-kB into the nucleus, where it can activate transcription. PMID: 15049289 Bcl10 is necessary for LPS induction of NF-kB and proliferation in MZ B cells but the requirement for Carma1 and MALT1 has not been tested. PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells. PMID: 15049289 Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun N-terminal kinase (JNK) and proliferation. PMID: 15049289, 10339464, 11090634, 11262391 Bcl10 binds to and cooperatively activates NF-kB with MALT1 (paracaspase), a protein that was also identified in MALT chromosomal translocations

PMID: 15049289 BCR activation of Carma1 might be mediated by protein kinase Cb (PKCb

PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells. PMID: 15049289, 10339464, 11090634, 11262391 Bcl10 binds to and cooperatively activates NF-kB with MALT1 (paracaspase), a protein that was also identified in MALT chromosomal translocations

PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells. PMID: 15049289, 10339464, 11090634, 11262391 Bcl10 binds to and cooperatively activates NF-kB with MALT1 (paracaspase), a protein that was also identified in MALT chromosomal translocations

PMID: 15049289 Bcl10 is necessary for LPS induction of NF-kB and proliferation in MZ B cells but the requirement for Carma1 and MALT1 has not been tested.

PMID: 15049289 Bcl10 is necessary for LPS induction of NF-kB and proliferation in MZ B cells but the requirement for Carma1 and MALT1 has not been tested.

PMID: 15049289 Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun N-terminal kinase (JNK) and proliferation.

PMID: 15049289 LPS signaling in follicular B cells does not require Bcl10 but might depend on Carma1 and MALT1

PMID: 15049289 LPS signaling in follicular B cells does not require Bcl10 but might depend on Carma1 and MALT1 Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun N-terminal kinase (JNK) and proliferation.

PMID: 15049289 Release of NF-kB is triggered by phosphorylation of IkB by the IkB kinase (IKK) kinase complex, leading to ubiquitin-mediated degradation of IkB and entry of NF-kB into the nucleus, where it can activate transcription. PMID: 15049289 Bcl10 is necessary for LPS induction of NF-kB and proliferation in MZ B cells but the requirement for Carma1 and MALT1 has not been tested. PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells. PMID: 15049289 Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun N-terminal kinase (JNK) and proliferation. PMID: 15049289, 10339464, 11090634, 11262391 Bcl10 binds to and cooperatively activates NF-kB with MALT1 (paracaspase), a protein that was also identified in MALT chromosomal translocations

PMID: 15049289 A wide variety of stimuli activate NF-kB, including mitogens for antigen receptors, proinflammatory cytokines and the bacterial product lipopolysaccharide (LPS). PMID: 15049289, 12910267 Bcl10 is required for full LPS activation of NF-kB in MZ B cells but not in follicular B cells.

PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.

PMID: 15049289 Release of NF-kB is triggered by phosphorylation of IkB by the IkB kinase (IKK) kinase complex, leading to ubiquitin-mediated degradation of IkB and entry of NF-kB into the nucleus, where it can activate transcription. PMID: 15049289 Bcl10 is necessary for LPS induction of NF-kB and proliferation in MZ B cells but the requirement for Carma1 and MALT1 has not been tested. PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells. PMID: 15049289 Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun N-terminal kinase (JNK) and proliferation. PMID: 15049289, 10339464, 11090634, 11262391 Bcl10 binds to and cooperatively activates NF-kB with MALT1 (paracaspase), a protein that was also identified in MALT chromosomal translocations

PMID: 15049289 Release of NF-kB is triggered by phosphorylation of IkB by the IkB kinase (IKK) kinase complex, leading to ubiquitin-mediated degradation of IkB and entry of NF-kB into the nucleus, where it can activate transcription. PMID: 15049289 Bcl10 is necessary for LPS induction of NF-kB and proliferation in MZ B cells but the requirement for Carma1 and MALT1 has not been tested. PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.

PMID: 15049289 Release of NF-kB is triggered by phosphorylation of IkB by the IkB kinase (IKK) kinase complex, leading to ubiquitin-mediated degradation of IkB and entry of NF-kB into the nucleus, where it can activate transcription.

PMID: 15049289 A wide variety of stimuli activate NF-kB, including mitogens for antigen receptors, proinflammatory cytokines and the bacterial product lipopolysaccharide (LPS).

PMID: 15049289 A wide variety of stimuli activate NF-kB, including mitogens for antigen receptors, proinflammatory cytokines and the bacterial product lipopolysaccharide (LPS).

PMID: 15049289 A wide variety of stimuli activate NF-kB, including mitogens for antigen receptors, proinflammatory cytokines and the bacterial product lipopolysaccharide (LPS).