1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15051069.csml convertedTime:2009.07.01.10:44

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2.
Authors Miyake K.
Affiliation Division of Infectious Genetics, Department of Microbiology and Immunology,Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Tokyo108-8639, Japan. kmiyake@ims.u-tokyo.ac.jp
Abstract Toll-like receptors (TLRs) are pathogen recognition molecules that activate theimmune system as part of the innate immune response. Microbial recognition byTLRs plays a crucial role in the host immune system's decision to respond or notto a particular microbial infection. Lipopolysaccharide (LPS), a membraneglycolipid of Gram-negative bacteria, exhibits strong immunostimulating activityamong TLR ligands and has been studied in great detail. Recent studies haveshown that cell surface TLR4-MD-2 physically interacts with LPS and triggers therelease of an LPS signal, revealing a host-pathogen interaction mediated by TLR.
PMID 15051069
Model Abstract

Entity

G010228:IFN-beta MO000000011:ERK MO000000022:p38 MO000000023:JNK MO000000212:TRAF6 MO000000248:IKK MO000016573:MyD88 MO000016653:RP105 MO000016882:LPS MO000018132:CD14 MO000019394:TLR4 MO000019420:LBP MO000021928:LPS:LBP MO000022131:MD-2 MO000022200:MD-1 MO000041125:TRIF MO000041132:TRAM e1: e10: e11:LPS:CD14 e12:LBP:sCD14 e13:TLR4:MD2 e14:LPS:TLR4:MD2 e15:(LPS:TLR4:MD2)n:MYD88 e16:(LPS:TLR4:MD2)n e17:IRAK1 e18:LPS:TLR4:MD2:MYD88:IRAK1 e19:IRAK4 e2: e20:LPS:TLR4:MD2:MYD88:IRAK1:IRAK4 e21:MD-2 e22:LPS:TLR4:MD2:MYD88:IRAK1{p}:IRAK4 e23:LPS:TLR4:MD2:MYD88:IRAK1{p}:IRAK4:TRAF6 e24:IKK e25:ERK{active} e26:p38 e27:JNK e28:IkappaBalpha:NFkappaB e29:IkappaBalpha{p}:NF-kappaB e3: e30:IkappaBalpha{p}:NF-kappaB e31:NF-kappaB e32:protein remnants e33:LPS:TLR4:MD2:TRIF e34:LPS:TLR4:MD2:TRAM e35:IRF3 e36:IRF3{active} e37:NF-kappaB{active} e38:IFN-alpha e39:IFN-beta e4: e40:IFN-alpha e41: e42: e43: e44: e45: e46: e47:gp96 e48: e49: e5:sCD14 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS:LBP:sCD14 e60: e61: e62: e63: e64: e65:TLR4:MD2 e66:TLR4{gly}:MD2 e67:TLR4{gly}:MD2 e68:LPS:MD2 e69:E5531 e7: e70:RP105:MD1 e71:LPS:RP105:MD1 e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p4 p5 p6 p7 p8 p9
Model Detail
849.0, 1205.0
38.0, 38.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p25

p26

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
932.0, 484.0
40.0, 40.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
838.0, 554.0
44.0, 44.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
932.0, 768.0
39.0, 39.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1132.0, 1136.0
40.0, 40.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
774.0, 234.0
36.0, 36.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1142.0, 682.0
36.0, 36.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1187.0, 1339.0
50.0, 50.0

RP105

--

MO000016653

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m1632

10

false

infinite

0

unit false false false
InterProIPR000483
TRANSPATHMO000016653

--

Go back
1583.0, 183.0
34.0, 34.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p31 p33

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1190.0, 230.0
44.0, 44.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p3

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
788.0, 1036.0
31.0, 31.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1347.0, 115.0
34.0, 34.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
1354.0, 238.0
35.0, 35.0

LPS:LBP

--

MO000021928

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p2

true true true true

csml-variable:Double

m6254

10

false

infinite

0

unit false false false
TRANSPATHMO000021928

--

Go back
822.0, 1014.0
36.0, 36.0

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
1239.0, 1395.0
42.0, 42.0

MD-1

--

MO000022200

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m6500

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022200

--

Go back
1104.0, 200.0
40.0, 40.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
971.0, 223.0
42.0, 42.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
396.4765302372901, 120.24172449575643
850.9151498079593, 1652.260886250939

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
403.67503845841475, 200.49576707184121
824.7973529157643, 1551.6019062360763

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1192.5, 318.0
31.0, 60.0

LPS:CD14

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p5

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1402.5, 362.7570404932511
34.49841693051158, 42.242959506748875

LBP:sCD14

--

e12

cso30:c:Complex

cso30:i:CC_Extracellular

--

p3

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
748.5, 982.0
39.0, 60.0

TLR4:MD2

--

e13

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p28

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1190.5, 546.0
43.0, 60.0

LPS:TLR4:MD2

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p6

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1198.0, 726.0
36.0, 60.0

(LPS:TLR4:MD2)n:MYD88

--

e15

cso30:c:Complex

cso30:i:CC_Extracellular

--

p7

p8

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1190.5, 630.0
43.0, 60.0

(LPS:TLR4:MD2)n

--

e16

cso30:c:Complex

cso30:i:CC_Extracellular

--

p6

p7 p19 p20

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1124.0, 786.2599999999999
48.32, 36.239999999999995

IRAK1

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1194.0, 838.0
36.0, 60.0

LPS:TLR4:MD2:MYD88:IRAK1

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p9

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1136.0, 901.7913938260058
23.05706267539757, 53.20860617399439

IRAK4

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
396.4765302372901, 120.24172449575643
850.9151498079593, 1652.260886250939

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1190.0, 958.0
36.0, 60.0

LPS:TLR4:MD2:MYD88:IRAK1:IRAK4

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p10

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1355.0, 455.0
26.0, 26.0

MD-2

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
1190.0, 1050.0
36.0, 60.0

LPS:TLR4:MD2:MYD88:IRAK1{p}:IRAK4

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p11

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1190.0, 1230.0
36.0, 60.0

LPS:TLR4:MD2:MYD88:IRAK1{p}:IRAK4:TRAF6

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

p12 p13 p14 p15

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
694.0, 306.0
36.0, 36.0

IKK

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

p16

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
932.0, 636.0
40.0, 40.0

ERK{active}

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

--

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
818.0, 702.0
44.0, 44.0

p38

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

--

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
959.0, 1010.5
34.5, 34.5

JNK

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

--

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
567.5, 355.84685885685724
33.60839860023329, 41.15314114314282

IkappaBalpha:NFkappaB

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
558.5, 510.97700383269455
34.318780203299454, 42.02299616730544

IkappaBalpha{p}:NF-kappaB

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p17

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
413.4948332334493, 143.0001389069265
816.8785438156414, 1606.7440574286

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
558.5, 698.9770038326945
34.318780203299454, 42.02299616730544

IkappaBalpha{p}:NF-kappaB

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p18

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
626.0, 906.4517005433688
51.970215335077484, 32.04829945663112

NF-kappaB

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

p18

p22 p23

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
518.0, 886.4078116025273
44.0608845491097, 42.592188397472725

protein remnants

--

e32

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p18

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1014.0, 126.0
36.0, 60.0

LPS:TLR4:MD2:TRIF

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p19

p21 p22

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
894.0, 126.0
36.0, 60.0

LPS:TLR4:MD2:TRAM

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p21 p23

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
729.5, 399.4469712215738
29.941034413362846, 48.553028778426246

IRF3

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p21

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
710.5, 557.5316965184143
27.54336888710002, 44.66492251962166

IRF3{active}

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

p21

p24 p25

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
566.0, 1088.4517005433688
51.970215335077484, 32.04829945663112

NF-kappaB{active}

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

p22 p23

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
720.0, 1215.1176470588236
48.529411764705884, 25.88235294117647

IFN-alpha

--

e38

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p24

p27

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
506.0, 1396.086838398068
52.56188367880862, 32.413161601931975

IFN-beta

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

p26

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
444.9786937763439, 182.82736412647364
753.9108227298526, 1527.0896069895045

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
515.0, 1156.9334876232642
49.567317367679614, 30.566512376735762

IFN-alpha

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

p27

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
689.4148824805553, 1006.1800283259281
221.09882338452405, 66.8272971001455

--

e41

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

--

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false true false

--

Go back
693.3249902896065, 1010.0901361349793
213.2786077664219, 59.00708148204327

--

e42

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulumLumen

--

--

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false true false

--

Go back
692.6140615970515, 1009.3792074424243
214.70046515153132, 60.42893886715277

--

e43

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false true false

--

Go back
689.4148824805553, 1006.1800283259281
221.09882338452405, 66.8272971001455

--

e44

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false true false

--

Go back
689.4148824805553, 1006.1800283259281
221.09882338452405, 66.8272971001455

--

e45

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false true false

--

Go back
691.5476685582196, 1008.3128144035923
216.83325122919564, 62.56172494481698

--

e46

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum

--

--

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false true false

--

Go back
875.5, 1040.5634936606964
24.319178909237273, 39.43650633930368

gp96

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
712.4604085992793, 836.4899185472027
231.53959140072092, 95.51008145279744

--

e48

cso30:c:EntityBiologicalCompartment

cso30:i:CC_GolgiLumen

--

--

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false true false

--

Go back
712.4604085992793, 836.4899185472027
231.53959140072092, 95.51008145279744

--

e49

cso30:c:EntityBiologicalCompartment

cso30:i:CC_GolgiApparatus

--

--

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false true false

--

Go back
1284.0, 184.97999999999996
39.36000000000001, 29.519999999999996

sCD14

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
564.5952714589681, 1082.0985870005534
438.12427155648794, 531.3463950281287

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
611.9159562825739, 1094.690724106563
256.1843971484866, 514.9804896371184

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
570.3063885928516, 1089.1904793366575
426.70203728872156, 517.1626103559197

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
571.1222624691208, 1090.2815396960582
425.07028953618305, 514.9804896371184

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
564.5952714589681, 1082.0985870005534
438.12427155648794, 531.3463950281287

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
564.5952714589681, 1082.0985870005534
438.12427155648794, 531.3463950281287

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
571.1222624691208, 1090.2815396960582
425.07028953618305, 514.9804896371184

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
884.4178309564418, 1300.310658880688
27.37159721125446, 33.13604994081652

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
812.6209298447644, 1453.0591091967813
77.50801824556119, 93.83119090845804

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
564.5952714589681, 1082.0985870005534
438.12427155648794, 531.3463950281287

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1423.5, 296.1583776839787
33.56982932648192, 46.841622316021294

LPS:LBP:sCD14

--

e6

cso30:c:Complex

cso30:i:CC_Extracellular

--

p2

p3

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
667.8586971092365, 1318.224534399646
13.874751924199556, 8.933683547097827

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
667.3953798688704, 1291.5821760054816
47.49001713754843, 114.31430520286676

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
687.3180212046227, 1365.932943617102
7.413075845861207, 9.913435681549416

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
712.4604085992793, 836.4899185472027
231.53959140072092, 95.51008145279744

--

e63

cso30:c:EntityBiologicalCompartment

cso30:i:CC_GolgiMembrane

--

--

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false true false

--

Go back
760.6978234744292, 848.5492722659903
129.27627186540252, 14.471224462545065

--

e64

cso30:c:EntityBiologicalCompartment

cso30:i:CC_GolgiTransFace

--

--

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false true false

--

Go back
752.5, 850.0
39.0, 60.0

TLR4:MD2

--

e65

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

p29

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
840.5, 850.0
39.0, 60.0

TLR4{gly}:MD2

--

e66

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p30

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1192.5, 394.0
39.0, 60.0

TLR4{gly}:MD2

--

e67

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p5

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1513.0, 523.403314917127
38.33701657458563, 42.59668508287293

LPS:MD2

--

e68

cso30:c:Complex

cso30:i:CC_Extracellular

--

p31

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1294.0, 499.0
60.0, 34.0

E5531

--

e69

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
407.65631417518733, 126.89055291854342
834.4826604778981, 1581.2662447423616

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1199.5, 1463.1383102816196
40.72037993667722, 49.86168971838027

RP105:MD1

--

e70

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

p33

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1202.5, 1558.0
43.0, 60.0

LPS:RP105:MD1

--

e71

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p33

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
410.63758989196, 154.79837414849024
800.5291597002079, 1554.4241034778827

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
418.5876584700202, 182.70619537843703
796.8743049683993, 1534.0382208642072

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1356.0, 188.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019420

MO000021928

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155666*m3985*0.1

nodelay

--

true

0

false

PMID: 15051069, 7537731 LPS-binding protein (LBP), a 60 kDa serum glycoprotein that binds to the lipid A moiety of LPS with a dissociation constant of 3.5 nM

Go back
1268.0, 1048.0
23.0, 23.0

p10

p10

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e20

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15051069, 11960013 IRAK4 is able to phosphorylate IRAK1.

Go back
1296.0, 1144.0
23.0, 23.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e22 MO000000212

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m22*m183*0.1

nodelay

--

true

0

false

PMID: 15051069 IRAK4 is able to phosphorylate IRAK1 [32], which together interact with TRAF6 (TNF receptor-associated factor 6).

Go back
780.0, 312.0
23.0, 23.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m207*m23*0.1

nodelay

--

true

0

false

PMID: 15051069, 12791976 TRAF6 can also lead to the activation of the I¦ÊB¦Á kinase complex (IKK)the phosphorylation and subsequent degradation of I¦ÊB¦Á, and finally the activation of NF-¦ÊBs

Go back
937.0, 560.0
27.0, 27.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000011 e23

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1

m25*m23*0.1

nodelay

--

true

0

false

PMID: 15051069 This then leads to the activation of mitogen-activated protein kinases (MAPKs), such as p38s, ERKs (extracellular signal-regulated kinases) and JNK (c-Jun N-terminal kinase).

Go back
828.0, 636.0
23.0, 23.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e23

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m27*m23*0.1

nodelay

--

true

0

false

PMID: 15051069 This then leads to the activation of mitogen-activated protein kinases (MAPKs), such as p38s, ERKs (extracellular signal-regulated kinases) and JNK (c-Jun N-terminal kinase).

Go back
939.0, 887.0
25.0, 25.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e23

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c45 : 1
stoichiometry:c44 : 1

m29*m23*0.1

nodelay

--

true

0

false

PMID: 15051069 This then leads to the activation of mitogen-activated protein kinases (MAPKs), such as p38s, ERKs (extracellular signal-regulated kinases) and JNK (c-Jun N-terminal kinase).

Go back
628.0, 432.0
23.0, 23.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e28 e24

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1

m31*m24*0.1

nodelay

--

true

0

false

PMID: 15051069, 12791976 TRAF6 can also lead to the activation of the I¦ÊB¦Á kinase complex (IKK)the phosphorylation and subsequent degradation of I¦ÊB¦Á, and finally the activation of NF-¦ÊBs

Go back
563.0, 615.0
26.0, 26.0

p17

p17

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 15051069, 12791976 TRAF6 can also lead to the activation of the I¦ÊB¦Á kinase complex (IKK)the phosphorylation and subsequent degradation of I¦ÊB¦Á, and finally the activation of NF-¦ÊBs.

Go back
565.0, 797.0
30.0, 30.0

p18

p18

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e30

e32 e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 15051069, 12791976 TRAF6 can also lead to the activation of the I¦ÊB¦Á kinase complex (IKK)the phosphorylation and subsequent degradation of I¦ÊB¦Á, and finally the activation of NF-¦ÊBs.

Go back
1061.0, 268.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000041125

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m16*m18998*0.1

nodelay

--

true

0

false

PMID: 15051069, 12471095, 14556004 Two TIR-containing adaptor molecules, TIR domain-containing adaptor-inducing interferon (IFN)-¦Â (TRIF, also known as TICAM-1) and TRIF-related adaptor molecule (TRAM), are demonstrated to work in concert to activate MyD88-independent activation of IFN regulatory factor 3 (IRF3), leading to the induction of IFN ¦Á/¦Â.

Go back
1361.0, 309.0
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 MO000021928

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m5*m6254*0.1

nodelay

--

true

0

false

PMID: 15051069 LBP removes LPS from the outer membrane and forms complexes consisting of LPS, LBP and soluble CD14 (sCD14).

Go back
1012.0, 416.0
24.0, 24.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000041132

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m16*m19005*0.1

nodelay

--

true

0

false

PMID: 15051069, 12471095, 14556004 Two TIR-containing adaptor molecules, TIR domain-containing adaptor-inducing interferon (IFN)-¦Â (TRIF, also known as TICAM-1) and TRIF-related adaptor molecule (TRAM), are demonstrated to work in concert to activate MyD88-independent activation of IFN regulatory factor 3 (IRF3), leading to the induction of IFN ¦Á/¦Â.

Go back
740.0, 492.0
23.0, 23.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e35 e34 e33

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c61 : 1

m38*m37*m36*0.1

nodelay

--

true

0

false

PMID: 15051069, 12471095, 14556004 Two TIR-containing adaptor molecules, TIR domain-containing adaptor-inducing interferon (IFN)-¦Â (TRIF, also known as TICAM-1) and TRIF-related adaptor molecule (TRAM), are demonstrated to work in concert to activate MyD88-independent activation of IFN regulatory factor 3 (IRF3), leading to the induction of IFN ¦Á/¦Â.

Go back
581.0, 998.0
21.0, 21.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 e33

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c65 : 1

m34*m36*0.1

nodelay

--

true

0

false

PMID: 15051069 The MyD88-independent pathway also activates NF-¦ÊB transcription factors.

Go back
653.0, 1001.0
21.0, 21.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 e34

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c69 : 1
stoichiometry:c68 : 1

m34*m37*0.1

nodelay

--

true

0

false

PMID: 15051069 The MyD88-independent pathway also activates NF-¦ÊB transcription factors.

Go back
731.0, 1131.0
25.0, 25.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e36

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c70 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 15051069, 12471095, 14556004 Two TIR-containing adaptor molecules, TIR domain-containing adaptor-inducing interferon (IFN)-¦Â (TRIF, also known as TICAM-1) and TRIF-related adaptor molecule (TRAM), are demonstrated to work in concert to activate MyD88-independent activation of IFN regulatory factor 3 (IRF3), leading to the induction of IFN ¦Á/¦Â.

Go back
845.0, 1145.0
21.0, 21.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e36

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c72 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 15051069, 12471095, 14556004 Two TIR-containing adaptor molecules, TIR domain-containing adaptor-inducing interferon (IFN)-¦Â (TRIF, also known as TICAM-1) and TRIF-related adaptor molecule (TRAM), are demonstrated to work in concert to activate MyD88-independent activation of IFN regulatory factor 3 (IRF3), leading to the induction of IFN ¦Á/¦Â.

Go back
518.0, 1319.5
25.5, 25.5

p26

p26

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m93217*0.1

nodelay

--

true

0

false

PMID: 15051069, 12471095, 14556004 Two TIR-containing adaptor molecules, TIR domain-containing adaptor-inducing interferon (IFN)-¦Â (TRIF, also known as TICAM-1) and TRIF-related adaptor molecule (TRAM), are demonstrated to work in concert to activate MyD88-independent activation of IFN regulatory factor 3 (IRF3), leading to the induction of IFN ¦Á/¦Â.

Go back
525.0, 1220.0
23.0, 23.0

p27

p27

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e38

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 15051069, 12471095, 14556004 Two TIR-containing adaptor molecules, TIR domain-containing adaptor-inducing interferon (IFN)-¦Â (TRIF, also known as TICAM-1) and TRIF-related adaptor molecule (TRAM), are demonstrated to work in concert to activate MyD88-independent activation of IFN regulatory factor 3 (IRF3), leading to the induction of IFN ¦Á/¦Â.

Go back
760.0, 940.0
23.0, 23.0

p28

p28

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e13

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c79 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 15051069 Toll-like receptor (TLR) 4 associates itself with MD-2 in the endoplasmic reticulum (ER) with the aid of a chaperone gp96 and then undergoes N-linked glycosylation in the Golgi apparatus before cell surface expression.

Go back
812.0, 800.0
23.0, 23.0

p29

p29

cso30:i:ME_N-Glycosylation

cso30:i:CC_Cytosol

--

e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 15051069 Toll-like receptor (TLR) 4 associates itself with MD-2 in the endoplasmic reticulum (ER) with the aid of a chaperone gp96 and then undergoes N-linked glycosylation in the Golgi apparatus before cell surface expression. PMID: 15051069, 12738639 Human MD-2 is required for human TLR4 glycosylation at residue positions Asn526 and Asn575, without which human TLR4 cannot get to the cell surface, even with MD-2 association.

Go back
1268.0, 232.0
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 MO000018132

e11 e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m6*m2828*0.1

nodelay

--

true

0

false

PMID: 15051069 These complexes deliver LPS to membrane CD14 for LPS signaling.

Go back
1028.0, 584.0
23.0, 23.0

p30

p30

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 15051069, 12738639 Human MD-2 is required for human TLR4 glycosylation at residue positions Asn526 and Asn575, without which human TLR4 cannot get to the cell surface, even with MD-2 association.

Go back
1435.0, 455.0
25.0, 25.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e21 MO000016882

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m21*m155666*0.1

nodelay

--

true

0

false

PMID: 15051069, 11500507 Human recombinant soluble MD-2 was shown to interact with LPS at an apparent dissociation constant of 65 nM, which is similar to the dissociation constant for binding of LPS to CD14 (30?74 nM).

Go back
1328.0, 1352.0
23.0, 23.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016653 MO000022200

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m1632*m6500*0.1

nodelay

--

true

0

false

PMID: 15051069, 7897216, 9686597, 11521060 Molecular cloning of MD-2 was preceded by the identification of radioproteictive105 (RP105) and associated MD-1.

Go back
1448.0, 1476.0
23.0, 23.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e70 MO000016882

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m73*m155666*0.1

nodelay

--

true

0

false

PMID: 15051069 RP105?MD-1 is a structurally related complex and has a role in the B cell response to LPS.

Go back
824.0, 948.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000022131 e47

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c78 : 1
stoichiometry:c13 : 1

m3961*m6438*m63*0.1

nodelay

--

true

0

false

PMID: 15051069 Toll-like receptor (TLR) 4 associates itself with MD-2 in the endoplasmic reticulum (ER) with the aid of a chaperone gp96. PMID: 15051069, 11593030 Association between human MD-2 and TLR4 occurs in the endoplasmic reticulum (ER).

Go back
1313.0, 337.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 e67 e69

e14 MO000018132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c84 : 1
stoichiometry:c88 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1

m11*m70*0.1

nodelay

--

true

0

false

PMID: 15051069 LPS bound to CD14 is transferred to Toll-like receptor (TLR) 4?MD-2, which undergoes oligomerization and triggers a signal. PMID: 15051069, 14517279 A lipid A antagonist, E5531, was shown to block LPS interaction with TLR4?MD-2 probably through direct interaction with TLR4?MD-2.

Go back
1424.0, 564.5
23.5, 23.5

p6

p6

cso30:i:ME_Oligomerization

cso30:i:CC_Extracellular

--

e14

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15051069 LPS bound to CD14 is transferred to Toll-like receptor (TLR) 4?MD-2, which undergoes oligomerization and triggers a signal.

Go back
1291.0, 691.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e16 MO000016573

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m16*m1572*0.1

nodelay

--

true

0

false

PMID: 15051069 The TIR domain of MyD88 is important for interaction with the cytoplasmic domain of TLR4.

Go back
1284.0, 796.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 e17

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m15*m17*0.1

nodelay

--

true

0

false

PMID: 15051069 The death domain of MyD88 recruits members of the (IL)-1 receptor-associated kinases (IRAKs), IRAK1 and IRAK4.

Go back
1317.0, 917.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m18*m19*0.1

nodelay

--

true

0

false

PMID: 15051069 The death domain of MyD88 recruits members of the (IL)-1 receptor-associated kinases (IRAKs), IRAK1 and IRAK4.

Go back
1387.0, 200.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1291.0, 255.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
810.0, 978.5777277565809

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
837.3716911948197, 978.9913606886246

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
794.3148177390107, 969.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
770.0, 970.9889426346601

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1224.0, 348.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1230.5164229118466, 358.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1240.063204452124, 276.2189607942333

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1234.0, 576.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1241.4938701929884, 581.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1365.0, 149.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1234.0, 670.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1178.0, 701.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1240.923410283849, 712.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1234.0, 768.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1172.0, 805.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1236.5424513544062, 817.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1230.0, 877.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1159.0, 928.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1233.171108776664, 934.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1226.0, 1006.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1369.0, 211.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1233.6921915811265, 1063.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1226.0, 1094.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1172.0, 1156.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1231.53863057437, 1167.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
792.0, 270.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.0, 324.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
800.2506232576972, 342.3098186322588

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
951.2221365379228, 524.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
951.0, 587.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
958.8077107519503, 594.4911120892283

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1312.0, 214.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.2244646123285, 598.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.0, 659.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
851.1194979089057, 665.8578230495195

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
952.0, 807.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
954.0, 912.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
965.6269413035362, 918.5262097862105

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
601.0, 397.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
595.7259108037559, 455.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.1159660434203, 342.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
576.0, 553.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1372.0, 273.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
576.0, 641.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.0, 741.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.1211922734731, 827.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.0, 827.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1079.7481755022175, 298.513157219772

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1039.0483717877987, 446.2059602232175

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1088.2063309876478, 240.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1044.5020050995781, 193.5986821542742

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
996.0, 265.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
927.0540812353584, 193.3940914119202

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1382.0, 320.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.0, 448.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
734.7898696961713, 515.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
761.328325273425, 186.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
767.0072470613969, 178.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
604.5135240402044, 938.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.0, 1019.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.6684742838222, 186.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
654.0, 938.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
608.9509778128281, 1022.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
669.2251514157615, 186.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1298.2299027111483, 252.42469075791234

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
744.0, 1156.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
725.0, 602.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
858.0, 1166.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
729.0, 602.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
551.6164882726274, 1230.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
531.0, 1345.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.9978375455747, 1228.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
538.0, 1195.9960966086967

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
845.658784100966, 978.1143024185452

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
772.0, 918.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1234.0, 245.93472998053917

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.0, 829.4

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.0, 823.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
879.0, 613.7572953387291

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.0, 449.63683017428986

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1232.0, 360.49400927243204

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1381.0, 468.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1458.9470510118, 217.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1460.0, 479.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1324.0, 362.0

c88

c88

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1237.0, 1364.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1228.5242268444122, 255.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1281.0, 1376.3042836233749

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1245.562330253742, 1375.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1240.0, 1488.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1461.8654234918495, 217.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1253.3606783017763, 1493.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back