1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15075354.csml convertedTime:2009.07.01.10:45

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Toll-like receptors and the host defense against microbial pathogens: bringingspecificity to the innate-immune system.
Authors Netea MG, van der Graaf C, Van der Meer JW, Kullberg BJ.
Affiliation Department of Medicine, University Medical Center St. Radboud, NijmegenUniversity, The Netherlands. M.Netea@aig.umcn.nl
Abstract Toll-like receptors (TLRs) have been identified as a major class ofpattern-recognition receptors. Recognition of pathogen-associated molecularpatterns (PAMPs) by TLRs, alone or in heterodimerization with other TLR ornon-TLR receptors, induces signals responsible for the activation of genesimportant for an effective host defense, especially proinflammatory cytokines.Although a certain degree of redundancy exists between signals induced by thevarious TLRs, recent studies have identified intracellular pathways specific forindividual TLRs. This leads to the release of cytokine profiles specific forparticular PAMPs, and thus, TLRs confer a certain degree of specificity to theinnate-immune response. In addition to the activation of the innate-immuneresponse, TLR-mediated recognition represents a link between the innate- andacquired-immune systems, by inducing the maturation of dendritic cells anddirecting the T helper responses. Alternatively, recent data have also suggestedTLR-mediated escape mechanisms used by certain pathogenic microorganisms,especially through TLR2 induction of anti-inflammatory cytokines. Finally, thecrucial role of TLRs for the host defense against infections has beenstrengthened recently by the description of patients partially defective in theTLR-activation pathways.
PMID 15075354
Model Abstract

Entity

G001062:IP-10 G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010514:iNOS G010657:IL-12 p40 G011345:IL10 MO000000058:NF-kappaB MO000000077:MAPKs MO000000212:TRAF6 MO000000213:IRAK1 MO000000265:chemokines MO000000276:AP-1 MO000000289:TNF-alpha MO000007384:IL-6 MO000016573:MyD88 MO000016660:IFNbeta MO000016882:LPS MO000016922:CD40 MO000017247:IL-10{extracellular} MO000017265:IL-12 MO000017269:CD80 MO000017270:CD86 MO000017793:Lp MO000018132:CD14 MO000019387:cytokines MO000019394:TLR4 MO000019395:TLRs MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000020461:Nod2 MO000021891:Hsp MO000022185:flagellin MO000022224:dsRNA MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000042012:TLR9 MO000042032:PGN MO000069513:dectin-1 e1: e10: e11:CD11b: CD18 e12:lipoteichoic acid: CD14 e13:LPS: CD11b: CD18 e14:LPS: CD11b: CD18: TLR4 e15:lipoteichoic acid e16:lipoteichoic acid: CD14: TLR4 e17:zymosan e18:zymosan: dectin-1 e19:zymosan: dectin-1: TLR2 e2: e20:PGN: TLR2 e21:Lp: TLR2 e22:Hsp: TLR4 e23:flagellin: TLR5 e24:CpG DNA e25:CpG DNA: TLR9 e26:PAMP e27:PAMP: TLR4 e28:PAMP: TLR4: MyD88 e29:PAMP: TLR4: MyD88: IRAK1 e3: e30:PAMP: TLR4: MyD88: IRAK1: TRAF6 e31:NF-kappaB{activated} e32:MAPKs{activated} e33:AP-1{activated} e34:proinflammatory cytokines e35:Ligand: TLR4 e36:Ligand: TLR4: TRAM e37:dsRNA:TLR3: TRIF e38:Ligand: TLR4: TRAM: TRIF e39:TLR2: TLR1 e4: e40:TLR2: TLR6 e41:triacetylated lipopeptides: TLR2: TLR1 e42:diacetylated Mycoplasma lipopeptide: TLR2: TLR6 e43:triacetylated lipopeptides e44:diacetylated Mycoplasma lipopeptide e45:NO e46:NO{extracellular} e47:reactive nitrogen e48:oxigen intermediates e49:reactive nitrogen{extracellular} e5:LPS: CD14 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS: CD14: TLR4 e60: e61: e62: e63:oxigen intermediates{extracellular} e64:microbial stimuli e65:ligand: TLR2 e66:chemokine e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p6 p7 p8 p9
Model Detail
565.0, 986.0
32.0, 32.0

IP-10

--

G001062

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p29 p30

true true true true

csml-variable:Double

m88001

10

false

infinite

0

unit false false false
Affymetrix1418930_at
EnsemblENSMUSG00000034855
MGDCxcl10
ProteomeHumanPSD/Cxcl10
RefSeqNM_021274
TRANSFACG001062
UnigeneMm.263514

--

Go back
524.0, 1036.0
32.0, 32.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p28 p27 p40

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
795.0, 1116.0
28.0, 28.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p39

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
822.0, 1011.0
30.0, 30.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
598.0, 963.0
30.0, 30.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p31 p32

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
819.0, 1068.0
28.0, 28.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
555.0, 1168.0
28.0, 28.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p55 p56

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
784.0, 709.0
33.0, 33.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
893.0, 314.0
32.0, 32.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
903.0, 244.0
27.0, 27.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
818.0, 235.0
30.0, 30.0

IRAK1

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
630.0, 1398.0
27.0, 27.0

chemokines

--

MO000000265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57

--

true true true true

csml-variable:Double

m211

10

false

infinite

0

unit false false false
TRANSPATHMO000000265

--

Go back
776.0, 905.0
34.0, 34.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
973.0, 1010.0
31.5, 31.5

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37

p45

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
970.0, 1119.0
30.0, 30.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
749.0, 234.0
31.5, 31.5

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
209.0, 1010.0
32.0, 32.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28 p27 p40

p44

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
325.0, 58.0
32.0, 32.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p3

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
395.0, 1128.0
28.5, 28.5

CD40

--

MO000016922

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46

--

true true true true

csml-variable:Double

m1837

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000016922

--

Go back
555.0, 1404.0
28.0, 28.0

IL-10{extracellular}

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55 p56

--

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
975.0, 1068.0
27.0, 27.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
398.0, 1163.0
29.5, 29.5

CD80

--

MO000017269

cso30:c:Protein

cso30:i:CC_CellComponent

--

p47

--

true true true true

csml-variable:Double

m2125

10

false

infinite

0

unit false false false
InterProIPR003599
TRANSPATHMO000017269

--

Go back
399.0, 1204.0
27.0, 27.0

CD86

--

MO000017270

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

--

true true true true

csml-variable:Double

m2126

10

false

infinite

0

unit false false false
InterProIPR003596
TRANSPATHMO000017270

--

Go back
181.0, 495.0
32.0, 32.0

Lp

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
489.0, 125.0
30.0, 30.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p5

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
825.0, 1374.0
31.5, 31.5

cytokines

--

MO000019387

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41 p49 p50 p51

--

true true true true

csml-variable:Double

m3957

10

false

infinite

0

unit false false false
TRANSPATHMO000019387

--

Go back
357.0, 177.0
30.0, 30.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p4 p6 p12

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
664.0, 189.0
26.0, 26.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
295.0, 396.0
28.0, 28.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p9 p10

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
288.0, 850.0
28.0, 28.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1041.0, 626.0
30.0, 30.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
654.0, 743.0
30.5, 30.5

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
165.0, 238.0
32.0, 32.0

Hsp

--

MO000021891

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m6220

10

false

infinite

0

unit false false false
TRANSPATHMO000021891

--

Go back
1107.0, 620.0
28.0, 28.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
163.0, 890.0
32.0, 32.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
367.0, 840.0
28.0, 28.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p26

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
432.0, 715.0
30.0, 30.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
285.0, 893.0
30.0, 30.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

p25

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
1045.0, 330.0
28.0, 28.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
182.0, 440.0
30.0, 30.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
193.0, 286.0
32.0, 32.0

dectin-1

--

MO000069513

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m44357

10

false

infinite

0

unit false false false
TRANSPATHMO000069513

--

Go back
271.07328050471915, 159.7536151248911
817.6053985245444, 1187.1630386576373

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
278.95085159150983, 177.89885246149709
792.5100035942205, 1114.8387334725332

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
222.625, 127.5
26.78016163972671, 32.79203466088985

CD11b: CD18

--

e11

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
579.625, 111.5
32.70000833194467, 40.04082652891185

lipoteichoic acid: CD14

--

e12

cso30:c:Complex

cso30:i:CC_Extracellular

--

p5

p6

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
287.875, 109.5
32.25, 45.0

LPS: CD11b: CD18

--

e13

cso30:c:Complex

cso30:i:CC_Extracellular

--

p3

p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
295.875, 189.5
32.25, 45.0

LPS: CD11b: CD18: TLR4

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p51 p52

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
573.5, 68.25
45.0, 25.5

lipoteichoic acid

--

e15

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
579.875, 162.5
32.25, 45.0

lipoteichoic acid: CD14: TLR4

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
101.5, 293.375
38.9543057996485, 25.32029876977153

zymosan

--

e17

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
168.625, 342.5
32.65101649725047, 39.98083652724546

zymosan: dectin-1

--

e18

cso30:c:Complex

cso30:i:CC_Extracellular

--

p7

p8

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
292.875, 339.5
32.25, 45.0

zymosan: dectin-1: TLR2

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
271.07328050471915, 159.7536151248911
817.6053985245444, 1187.1630386576373

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
294.625, 437.5
29.27874520913181, 35.851524745875686

PGN: TLR2

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
293.625, 492.5
30.25858190301616, 37.05132477920347

Lp: TLR2

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p35 p36 p50 p54

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
293.625, 283.5
30.9199716713881, 37.861189801699716

Hsp: TLR4

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1041.625, 671.5
28.07027995334111, 34.37177137143809

flagellin: TLR5

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1104.5, 312.125
45.0, 15.75

CpG DNA

--

e24

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p14

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1047.625, 373.5
31.00979003499417, 37.97117147142143

CpG DNA: TLR9

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p49 p53

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
659.0, 73.5
32.33743409490334, 21.01933216168717

PAMP

--

e26

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p15

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
717.625, 179.5
30.9199716713881, 37.861189801699716

PAMP: TLR4

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

p16

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
792.875, 167.5
32.25, 45.0

PAMP: TLR4: MyD88

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

p17 p37 p38 p39 p40 p41 p42 p43

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
868.875, 159.5
32.25, 45.0

PAMP: TLR4: MyD88: IRAK1

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p17

p18

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
287.42538847521007, 176.10572309538202
784.9011825835629, 1154.4588227166562

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
948.875, 143.5
36.037850981831525, 50.28537346302073

PAMP: TLR4: MyD88: IRAK1: TRAF6

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

p19 p20

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
784.0, 757.0
33.0, 33.0

NF-kappaB{activated}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

p22

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
893.0, 358.0
32.0, 32.0

MAPKs{activated}

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19

p21

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
780.0, 953.0
34.0, 34.0

AP-1{activated}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

p23

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
655.5, 945.0
34.775086505190316, 18.546712802768166

proinflammatory cytokines

--

e34

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p22 p23 p35

p41 p49 p50 p51

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
296.625, 711.5
29.629853357773698, 36.28145309115148

Ligand: TLR4

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p24 p57

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
296.625, 759.5
29.409390101649723, 36.011498083652725

Ligand: TLR4: TRAM

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

p26 p28 p30 p32

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
294.625, 936.5
28.960298283619398, 35.46158973504416

dsRNA:TLR3: TRIF

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p25

p27 p29 p31

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
289.875, 803.5
28.935630390897412, 40.37529821985685

Ligand: TLR4: TRAM: TRIF

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p26

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
297.625, 540.5
27.890643226128983, 34.15180803199466

TLR2: TLR1

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p33

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
317.6767882206183, 204.72191204374087
724.3983830927466, 1097.2264448199378

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
296.625, 627.5
23.840651558073656, 29.192634560906512

TLR2: TLR6

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p34

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
296.875, 585.5
24.327078363002386, 33.94476050651495

triacetylated lipopeptides: TLR2: TLR1

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
291.875, 666.5
27.238988805285373, 38.00789135621215

diacetylated Mycoplasma lipopeptide: TLR2: TLR6

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
173.5, 543.25
38.086627417998315, 21.582422203532378

triacetylated lipopeptides

--

e43

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p33

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
170.5, 631.25
37.884777123633306, 21.468040370058873

diacetylated Mycoplasma lipopeptide

--

e44

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p34

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
413.5, 474.5
39.117647058823536, 23.47058823529412

NO

--

e45

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p36

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
101.5, 474.5
39.117647058823536, 23.47058823529412

NO{extracellular}

--

e46

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
942.5, 489.25
45.0, 25.5

reactive nitrogen

--

e47

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p42

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
942.5, 545.25
45.0, 25.5

oxigen intermediates

--

e48

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p43

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1106.5, 485.25
45.0, 25.5

reactive nitrogen{extracellular}

--

e49

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p42

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
415.5, 112.0
33.42876187302116, 40.933177803699394

LPS: CD14

--

e5

cso30:c:Complex

cso30:i:CC_Extracellular

--

p2

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
444.14113013875766, 844.3891092590632
444.6292770513708, 403.22990302424165

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
492.1644040102278, 853.9450717566642
259.98806889037337, 390.8100908161027

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
449.9370425025558, 849.77102788259
433.03745232377486, 392.4660657771878

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
450.76502998309843, 850.5990153631325
431.38147736268945, 390.8100908161027

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
444.14113013875766, 844.3891092590632
444.6292770513708, 403.22990302424165

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
444.14113013875766, 844.3891092590632
444.6292770513708, 403.22990302424165

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
450.76502998309843, 850.5990153631325
431.38147736268945, 390.8100908161027

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
768.7122225114529, 1009.986605367581
27.77799421279553, 25.146394761057035

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
695.8493242237051, 1125.904852643544
78.65881065154605, 71.20692332666282

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
444.14113013875766, 844.3891092590632
444.6292770513708, 403.22990302424165

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
476.5, 170.0
31.620664342081113, 44.121857221508535

LPS: CD14: TLR4

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
548.9377489830235, 1023.5811462469178
14.080755890120928, 6.779623206354526

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
548.467552687124, 1003.3627055232405
48.195120329696024, 86.75121659345284

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
568.6859934108018, 1059.7862610311777
7.523140734391567, 7.5231407343915695

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1106.5, 533.25
45.0, 25.5

oxigen intermediates{extracellular}

--

e63

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p43

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
208.5, 1167.375
33.154657293497365, 21.550527240773285

microbial stimuli

--

e64

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p46 p47 p48

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
416.625, 1296.5
31.279245125812363, 38.30111648058657

ligand: TLR2

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p56

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
625.5, 1176.0
37.110726643598625, 19.792387543252595

chemokine

--

e66

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p57

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
281.8154228957974, 164.5308530414886
801.8161720775979, 1136.1528047151198

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
284.67999420008493, 184.58285217150132
769.1918081314251, 1116.8665054068294

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
292.3188510115183, 204.63485130151412
765.6800255991434, 1102.2190810498425

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
418.0, 178.0
27.0, 27.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000019394 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3961*m5*0.1

nodelay

--

true

0

false

PMID: 15075354, 12072369, 7500012, 12719478, 12719479 As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].

Go back
236.0, 498.0
26.0, 26.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000017793

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m3964*m2549*0.1

nodelay

--

true

0

false

PMID: 15075354, 12527213 The specificity of TLR recognition for several important PAMPs has been identified, including recognition of peptidoglycan (PGN), bacterial lipoproteins, and zymosan by TLR2; double-stranded RNA by TLR3; lipopolysaccharide (LPS) and heat-shock proteins (HSPs) by TLR4; flagellin by TLR5; and CpG motifs of bacterial DNA by TLR9 [5 ].

Go back
222.0, 893.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 15075354, 12527213 The specificity of TLR recognition for several important PAMPs has been identified, including recognition of peptidoglycan (PGN), bacterial lipoproteins, and zymosan by TLR2; double-stranded RNA by TLR3; lipopolysaccharide (LPS) and heat-shock proteins (HSPs) by TLR4; flagellin by TLR5; and CpG motifs of bacterial DNA by TLR9 [5 ].

Go back
224.0, 241.0
25.0, 25.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019394 MO000021891

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c42 : 1

m3961*m6220*0.1

nodelay

--

true

0

false

PMID: 15075354, 12527213 The specificity of TLR recognition for several important PAMPs has been identified, including recognition of peptidoglycan (PGN), bacterial lipoproteins, and zymosan by TLR2; double-stranded RNA by TLR3; lipopolysaccharide (LPS) and heat-shock proteins (HSPs) by TLR4; flagellin by TLR5; and CpG motifs of bacterial DNA by TLR9 [5 ].

Go back
1107.0, 672.0
27.0, 27.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 MO000022185

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 15075354, 12527213 The specificity of TLR recognition for several important PAMPs has been identified, including recognition of peptidoglycan (PGN), bacterial lipoproteins, and zymosan by TLR2; double-stranded RNA by TLR3; lipopolysaccharide (LPS) and heat-shock proteins (HSPs) by TLR4; flagellin by TLR5; and CpG motifs of bacterial DNA by TLR9 [5 ].

Go back
1114.0, 379.0
25.0, 25.0

p14

p14

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000042012 e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m19828*m24*0.1

nodelay

--

true

0

false

PMID: 15075354, 12527213 The specificity of TLR recognition for several important PAMPs has been identified, including recognition of peptidoglycan (PGN), bacterial lipoproteins, and zymosan by TLR2; double-stranded RNA by TLR3; lipopolysaccharide (LPS) and heat-shock proteins (HSPs) by TLR4; flagellin by TLR5; and CpG motifs of bacterial DNA by TLR9 [5 ].

Go back
665.0, 114.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e26 MO000019395

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m26*m3962*0.1

nodelay

--

true

0

false

PMID: 15075354 The TLR?PAMP interaction results in the recruitment of specific adaptor molecules such as MyD88 and Mal, which then bind the IL-1R-associated kinase (IRAK).

Go back
752.0, 89.0
26.0, 26.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e27 MO000016573

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1

m27*m1572*0.1

nodelay

--

true

0

false

PMID: 15075354 The TLR?PAMP interaction results in the recruitment of specific adaptor molecules such as MyD88 and Mal, which then bind the IL-1R-associated kinase (IRAK).

Go back
820.0, 85.0
25.0, 25.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e28 MO000000213

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m28*m184*0.1

nodelay

--

true

0

false

PMID: 15075354 The TLR?PAMP interaction results in the recruitment of specific adaptor molecules such as MyD88 and Mal, which then bind the IL-1R-associated kinase (IRAK).

Go back
904.0, 81.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000212 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c53 : 1

m183*m29*0.1

nodelay

--

true

0

false

PMID: 15075354, 11044373 The signal is thereafter transmitted through a chain of signaling molecules, which is apparently common to all TLRs, involving the tumor necrosis factor (TNF) receptor-associated factor-6 (TRAF6) and mitogen-activated protein kinases.

Go back
953.0, 318.0
24.0, 24.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e30 MO000000077

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m31*m69*0.1

nodelay

--

true

0

false

PMID: 15075354, 11044373 The signal is thereafter transmitted through a chain of signaling molecules, which is apparently common to all TLRs, involving the tumor necrosis factor (TNF) receptor-associated factor-6 (TRAF6) and mitogen-activated protein kinases.

Go back
418.0, 62.0
27.0, 27.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000018132

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m155666*m2828*0.1

nodelay

--

true

0

false

PMID: 15075354, 12072369, 7500012, 12719478, 12719479 As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].

Go back
851.0, 712.0
27.0, 27.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c58 : 1
stoichiometry:c57 : 1

m30*m31*0.1

nodelay

--

true

0

false

PMID: 15075354 Thereafter, activation of nuclear factor NF-kappaB and activated protein-1 (AP-1) leads to transcription of genes involved in the activation of the innate host defense, notably proinflammatory cytokines.

Go back
844.0, 957.0
25.0, 25.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e32 MO000000276

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m33*m219*0.1

nodelay

--

true

0

false

PMID: 15075354 Thereafter, activation of nuclear factor NF-kappaB and activated protein-1 (AP-1) leads to transcription of genes involved in the activation of the innate host defense, notably proinflammatory cytokines.

Go back
720.0, 913.0
25.0, 25.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c64 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 15075354 Thereafter, activation of nuclear factor NF-kappaB and activated protein-1 (AP-1) leads to transcription of genes involved in the activation of the innate host defense, notably proinflammatory cytokines.

Go back
721.0, 958.0
23.0, 23.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c65 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 15075354 Thereafter, activation of nuclear factor NF-kappaB and activated protein-1 (AP-1) leads to transcription of genes involved in the activation of the innate host defense, notably proinflammatory cytokines.

Go back
369.0, 716.0
27.0, 27.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e35 MO000041132

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c76 : 1
stoichiometry:c69 : 1

m36*m19005*0.1

nodelay

--

true

0

false

PMID: 15075354, 14556004 Moreover, a recent study described TRAM as an adaptor molecule specifically recruited to TLR4. PMID: 15075354 Ligation of TLR4 recruits TRIF and transverse rectus abdominis musculocutaneous (TRAM), mediating unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IP-10 and iNOS.

Go back
367.0, 895.0
25.0, 25.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 15075354, 12855817, 12872135 Ligation of TLR4 or TLR3 recruits an additional adaptor molecule called TIR domain-containing, adapter-inducing interferon-? (IFN-beta; TRIF).

Go back
369.0, 794.0
23.0, 23.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 MO000041125

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c74 : 1

m37*m18998*0.1

nodelay

--

true

0

false

PMID: 15075354, 12855817, 12872135 Ligation of TLR4 or TLR3 recruits an additional adaptor molecule called TIR domain-containing, adapter-inducing interferon-? (IFN-beta; TRIF). PMID: 15075354 Ligation of TLR4 recruits TRIF and transverse rectus abdominis musculocutaneous (TRAM), mediating unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IP-10 and iNOS.

Go back
392.0, 1033.0
25.0, 25.0

p27

p27

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e37

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c80 : 1
stoichiometry:c82 : 1

m93217*m38*0.1

nodelay

--

true

0

false

PMID: 15075354 In addition to potentiating the secretion of the proinflammatory cytokines, TRIF mediates unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IFN-inducible protein 10 (IP-10) and inducible nitric oxide synthase (iNOS).

Go back
392.0, 985.0
25.0, 25.0

p28

p28

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e36

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c79 : 1
stoichiometry:c81 : 1

m93217*m37*0.1

nodelay

--

true

0

false

PMID: 15075354 In addition to potentiating the secretion of the proinflammatory cytokines, TRIF mediates unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IFN-inducible protein 10 (IP-10) and inducible nitric oxide synthase (iNOS). PMID: 15075354 Ligation of TLR4 recruits TRIF and transverse rectus abdominis musculocutaneous (TRAM), mediating unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IP-10 and iNOS.

Go back
493.0, 990.0
23.0, 23.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

G001062 e37

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c86 : 1

m88001*m38*0.1

nodelay

--

true

0

false

PMID: 15075354 In addition to potentiating the secretion of the proinflammatory cytokines, TRIF mediates unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IFN-inducible protein 10 (IP-10) and inducible nitric oxide synthase (iNOS).

Go back
223.0, 63.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e11

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m155666*m11*0.1

nodelay

--

true

0

false

PMID: 15075354, 12072369, 7500012, 12719478, 12719479 As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].

Go back
504.0, 953.0
25.0, 25.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e36 G001062

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c89 : 1

m37*m88001*0.1

nodelay

--

true

0

false

PMID: 15075354 In addition to potentiating the secretion of the proinflammatory cytokines, TRIF mediates unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IFN-inducible protein 10 (IP-10) and inducible nitric oxide synthase (iNOS). PMID: 15075354 Ligation of TLR4 recruits TRIF and transverse rectus abdominis musculocutaneous (TRAM), mediating unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IP-10 and iNOS.

Go back
537.0, 906.0
23.0, 23.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c87 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 15075354 In addition to potentiating the secretion of the proinflammatory cytokines, TRIF mediates unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IFN-inducible protein 10 (IP-10) and inducible nitric oxide synthase (iNOS).

Go back
571.0, 884.0
27.0, 27.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e36

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c88 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 15075354 In addition to potentiating the secretion of the proinflammatory cytokines, TRIF mediates unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IFN-inducible protein 10 (IP-10) and inducible nitric oxide synthase (iNOS). PMID: 15075354 Ligation of TLR4 recruits TRIF and transverse rectus abdominis musculocutaneous (TRAM), mediating unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IP-10 and iNOS.

Go back
180.0, 589.0
25.0, 25.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e43 e39

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m44*m40*0.1

nodelay

--

true

0

false

PMID: 15075354, 11431423 In this way, heterodimers of TLR2/TLR1 recognize triacetylated bacterial lipopeptides, whereas TLR2/TLR6 heterodimeres recognize diacetylated Mycoplasma lipopeptides [16 ], and similar heterodimerization is likely to occur for other PAMPs.

Go back
176.0, 673.0
25.0, 25.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e40 e44

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m41*m45*0.1

nodelay

--

true

0

false

PMID: 15075354, 11431423 In this way, heterodimers of TLR2/TLR1 recognize triacetylated bacterial lipopeptides, whereas TLR2/TLR6 heterodimeres recognize diacetylated Mycoplasma lipopeptides [16 ], and similar heterodimerization is likely to occur for other PAMPs.

Go back
657.0, 882.0
23.0, 23.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21 MO000020461

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m21*m4947*0.1

nodelay

--

true

0

false

PMID: 15075354 Our recent finding that NOD2, an intracellular molecule involved in the pathogenesis of Crohn¡Çs disease, specifically mediates cytokine induction by TLR2 but not TLR4 agonists indicates that it may be part of a TLR2-specific pathway.

Go back
361.0, 474.0
23.0, 23.0

p36

p36

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e45 e21

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c102 : 1
stoichiometry:c101 : 1

m46*m21*0.1

nodelay

--

true

0

false

PMID: 15075354, 12917260 TLR2 also mediates host defense against T. gondii by mediating cytokine and NO release.

Go back
912.0, 1013.0
25.0, 25.0

p37

p37

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e28 G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c107 : 1
stoichiometry:c105 : 1

m28*m93309*0.1

nodelay

--

true

0

false

PMID: 15075354 MyD88 is essential for the stimulation of proinflammatory cytokines such as TNF, IL-1beta, IL-12, or IL-6, virtually by the entire range of TLR agonists.

Go back
908.0, 1069.0
25.0, 25.0

p38

p38

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657 e28

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c104 : 1

m93589*m28*0.1

nodelay

--

true

0

false

PMID: 15075354 MyD88 is essential for the stimulation of proinflammatory cytokines such as TNF, IL-1beta, IL-12, or IL-6, virtually by the entire range of TLR agonists.

Go back
910.0, 1119.0
25.0, 25.0

p39

p39

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e28

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c111 : 1
stoichiometry:c106 : 1

m93248*m28*0.1

nodelay

--

true

0

false

PMID: 15075354 MyD88 is essential for the stimulation of proinflammatory cytokines such as TNF, IL-1beta, IL-12, or IL-6, virtually by the entire range of TLR agonists.

Go back
223.0, 199.0
25.0, 25.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 MO000019394

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m13*m3961*0.1

nodelay

--

true

0

false

PMID: 15075354, 12072369, 7500012, 12719478, 12719479 As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].

Go back
391.0, 1080.0
27.0, 27.0

p40

p40

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e28

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c112 : 1

m93217*m28*0.1

nodelay

--

true

0

false

PMID: 15075354 MyD88 is essential for the stimulation of proinflammatory cytokines such as TNF, IL-1beta, IL-12, or IL-6, virtually by the entire range of TLR agonists. PMID: 15075354, 12761116 The stimulation of specific TLRs results in the release of IL-10 or IL-12, leading to skewing of the T cell response toward Th1 or Th2 cytokines.

Go back
828.0, 1217.0
25.0, 25.0

p41

p41

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e34 e28

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c117 : 1
stoichiometry:c116 : 1

m35*m28*0.1

nodelay

--

true

0

false

PMID: 15075354, 12244183, 12055206 The protective mechanisms triggered through MyD88 mainly include release of proinflammatory cytokines and of reactive nitrogen and oxygen intermediates.

Go back
1038.0, 483.0
27.0, 27.0

p42

p42

cso30:i:ME_Translocation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e47 e28

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c122 : 1
stoichiometry:c119 : 1

m48*m28*0.1

nodelay

--

true

0

false

PMID: 15075354, 12244183, 12055206 The protective mechanisms triggered through MyD88 mainly include release of proinflammatory cytokines and of reactive nitrogen and oxygen intermediates.

Go back
1041.0, 534.0
23.0, 23.0

p43

p43

cso30:i:ME_Translocation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e48 e28

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c123 : 1
stoichiometry:c121 : 1

m49*m28*0.1

nodelay

--

true

0

false

PMID: 15075354, 12244183, 12055206 The protective mechanisms triggered through MyD88 mainly include release of proinflammatory cytokines and of reactive nitrogen and oxygen intermediates.

Go back
114.0, 1015.0
25.0, 25.0

p44

p44

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000016660

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1

m1636*0.1

nodelay

--

true

0

false

PMID: 15075354 Stimulation of immature DC by microbial stimuli induces production of proinflammatory cytokines such as TNF and IL-12, which can induce differentiation of T cells into T helper cell type 1 (Th1) cells.

Go back
1150.0, 1019.0
29.0, 29.0

p45

p45

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000000289

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 15075354 Stimulation of immature DC by microbial stimuli induces production of proinflammatory cytokines such as TNF and IL-12, which can induce differentiation of T cells into T helper cell type 1 (Th1) cells.

Go back
344.0, 1129.0
25.0, 25.0

p46

p46

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e64

MO000016922

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c126 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 15075354, 9521319 In addition, these stimuli induce up-regulation of costimulatory molecules such as CD40, CD80, and CD86.

Go back
342.0, 1163.0
27.0, 27.0

p47

p47

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e64

MO000017269

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c127 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 15075354, 9521319 In addition, these stimuli induce up-regulation of costimulatory molecules such as CD40, CD80, and CD86.

Go back
344.0, 1205.0
25.0, 25.0

p48

p48

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e64

MO000017270

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c128 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 15075354, 9521319 In addition, these stimuli induce up-regulation of costimulatory molecules such as CD40, CD80, and CD86.

Go back
790.0, 1243.0
22.0, 22.0

p49

p49

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e25 e34

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m25*m35*0.1

nodelay

--

true

0

false

PMID: 15075354, 11286707, 11561001 A variety of microbial PAMPs are able to induce cytokine release and DC maturation: LPS through TLR4, CpG through TLR9, bacterial lipopeptides through TLR2.

Go back
492.0, 69.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 MO000018132

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m15*m2828*0.1

nodelay

--

true

0

false

PMID: 15075354, 12072369, 7500012, 12719478, 12719479 As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].

Go back
743.0, 1248.0
27.0, 27.0

p50

p50

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e21 e34

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1

m21*m35*0.1

nodelay

--

true

0

false

PMID: 15075354, 11286707, 11561001 A variety of microbial PAMPs are able to induce cytokine release and DC maturation: LPS through TLR4, CpG through TLR9, bacterial lipopeptides through TLR2.

Go back
706.0, 1255.0
25.0, 25.0

p51

p51

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e14 e34

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c140 : 1

m14*m35*0.1

nodelay

--

true

0

false

PMID: 15075354, 11286707, 11561001 A variety of microbial PAMPs are able to induce cytokine release and DC maturation: LPS through TLR4, CpG through TLR9, bacterial lipopeptides through TLR2.

Go back
114.0, 135.0
27.0, 27.0

p52

p52

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e14

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15075354, 11286707, 11561001 A variety of microbial PAMPs are able to induce cytokine release and DC maturation: LPS through TLR4, CpG through TLR9, bacterial lipopeptides through TLR2.

Go back
1112.0, 441.0
25.0, 25.0

p53

p53

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e25

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 15075354, 11286707, 11561001 A variety of microbial PAMPs are able to induce cytokine release and DC maturation: LPS through TLR4, CpG through TLR9, bacterial lipopeptides through TLR2. PMID: 15075354, 11286707 One pathway induced mainly by TLR9 is strictly dependent on MyD88, whereas another pathway induced primarily by TLR4 can induce DC maturation through a MyD88-independent mechanism.

Go back
109.0, 514.0
23.0, 23.0

p54

p54

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e21

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 15075354, 11286707, 11561001 A variety of microbial PAMPs are able to induce cytokine release and DC maturation: LPS through TLR4, CpG through TLR9, bacterial lipopeptides through TLR2.

Go back
553.0, 1249.0
30.0, 30.0

p55

p55

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011345

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m94230*0.1

nodelay

--

true

0

false

PMID: 15075354, 12761116 The stimulation of specific TLRs results in the release of IL-10 or IL-12, leading to skewing of the T cell response toward Th1 or Th2 cytokines.

Go back
493.0, 1249.0
30.0, 30.0

p56

p56

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011345 e65

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c146 : 1

m94230*m66*0.1

nodelay

--

true

0

false

PMID: 15075354, 12391013 Yersinia enterocolitica and C. albicans have been shown to exploit TLR2-mediated IL-10 release to induce immunosuppression. PMID: 15075354 Thus, whereas interaction of Candida mannan with TLR4 induces release of chemokines, leukocyte recruitment, and protection, interaction of Candida glucans and phospholipomannan with TLR2 primarily mediates release of the anti-inflammatory cytokine IL-10, resulting in inhibition of the host defense and increased susceptibility to infection.

Go back
631.0, 1283.0
25.0, 25.0

p57

p57

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e66 e35

MO000000265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1

m67*m36*0.1

nodelay

--

true

0

false

PMID: 15075354 Thus, whereas interaction of Candida mannan with TLR4 induces release of chemokines, leukocyte recruitment, and protection, interaction of Candida glucans and phospholipomannan with TLR2 primarily mediates release of the anti-inflammatory cytokine IL-10, resulting in inhibition of the host defense and increased susceptibility to infection.

Go back
516.0, 229.0
23.0, 23.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e12 MO000019394

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m12*m3961*0.1

nodelay

--

true

0

false

PMID: 15075354, 12072369, 7500012, 12719478, 12719479 As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].

Go back
108.0, 349.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e17 MO000069513

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m17*m44357*0.1

nodelay

--

true

0

false

PMID: 15075354, 12072369, 7500012, 12719478, 12719479 As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].

Go back
241.0, 350.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m3964*m18*0.1

nodelay

--

true

0

false

PMID: 15075354, 12072369, 7500012, 12719478, 12719479 As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].

Go back
236.0, 442.0
25.0, 25.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000042032

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c27 : 1
stoichiometry:c26 : 1

m3964*m155701*0.1

nodelay

--

true

0

false

PMID: 15075354, 12527213 The specificity of TLR recognition for several important PAMPs has been identified, including recognition of peptidoglycan (PGN), bacterial lipoproteins, and zymosan by TLR2; double-stranded RNA by TLR3; lipopolysaccharide (LPS) and heat-shock proteins (HSPs) by TLR4; flagellin by TLR5; and CpG motifs of bacterial DNA by TLR9 [5 ].

Go back
387.0, 192.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.19588680098812, 151.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 486.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
149.0, 486.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
324.0, 493.83113677932715

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
811.0, 69.51897798108143

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
933.0, 1082.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
937.0, 1026.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
935.0, 1133.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.0, 1026.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
847.0, 1082.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
823.0, 1130.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
255.11397807407278, 192.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
809.0, 54.015444246572656

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
801.0111046050699, 38.01431901094833

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
248.4782686447068, 1034.8417420849885

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
425.63839984092334, 1057.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
84.65729482141865, 37.848933569613564

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
679.0, 964.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
841.0, 1242.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
792.9906061560179, 26.014525578687483

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
988.0, 498.47913832582356

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1065.0, 497.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
248.0, 212.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 549.0475069540363

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.0, 546.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
811.0, 213.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
809.0, 213.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
146.99673669168556, 1026.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1005.0, 1027.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
369.0, 1142.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
369.0, 1177.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
369.0, 1218.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
242.0, 1148.1177358542493

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
523.0, 81.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
242.0, 1177.0799960003

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
242.0, 1183.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
819.9999992290434, 400.0

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
677.0, 964.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
804.0, 1265.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
64.61208753259774, 515.0

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
96.53093850423039, 215.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
674.0, 964.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
676.0, 964.0

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
766.0, 1275.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.0, 100.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
731.0, 1280.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
148.56970539325195, 155.58835087640227

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1079.0, 408.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
139.97436547166782, 512.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
568.1509165355809, 1196.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
568.0, 1279.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
514.0, 1279.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
523.819255247295, 1196.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
448.0, 1278.5384418900119

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
515.0, 87.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
644.0, 1196.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
644.0, 1308.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
112.23525592439256, 728.0265457763494

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
540.232063414382, 152.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
539.0, 215.99933117450453

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
387.0, 205.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
121.0, 319.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 153.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.60515713200652, 313.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
133.0, 362.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
270.03265276709044, 376.2542459584336

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
201.0, 362.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
264.0, 362.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
267.4452081011954, 421.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
261.0, 455.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
212.0, 455.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
261.0886031430172, 424.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
213.0, 511.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
445.0, 192.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
262.0, 511.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
253.75606862759741, 873.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
195.0, 906.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
247.0, 906.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.99999760558586, 207.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
197.0, 254.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1071.0, 651.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1121.0, 648.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1077.9970797589829, 687.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1073.0, 354.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.0, 74.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1127.0, 328.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1087.0, 392.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
249.0, 262.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.0, 95.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.0, 145.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
686.0, 137.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
739.0, 122.57772775658087

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
771.0, 115.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
765.0, 123.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
815.0, 117.74517529289281

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
450.98677551382514, 93.30646011452681

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.0, 118.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.0, 110.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
917.0, 114.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
925.0, 106.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
893.0, 113.50199008578963

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
965.1290154777461, 194.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
817.0, 726.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.3548626638176, 736.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
885.9999997810146, 169.0

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
925.0, 330.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 89.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
931.2905467105794, 339.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
876.9994232983034, 390.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
810.0, 935.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.0, 970.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
697.2494651199621, 932.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
697.7462185896749, 960.9990241521741

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
742.2656264948855, 790.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.0, 970.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
326.0, 730.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
332.63257703060543, 739.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
255.99730276458956, 74.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
315.0, 908.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
380.29609328407906, 868.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
330.7039846776599, 916.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
326.0, 784.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
326.77909841584415, 809.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
381.0, 825.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.0, 730.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.4230194818756, 1005.9830825955202

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
424.99441584435925, 1047.2988566670788

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
326.0, 780.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
236.0, 96.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.94693552023574, 972.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
248.90082688116684, 1000.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
248.94977739241796, 1028.895008050802

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
326.0, 761.7804739479102

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
326.0, 778.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
324.0, 921.1885398205029

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
324.0, 958.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
560.0, 928.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.0, 911.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
535.9932582089723, 976.885143449429

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
248.0, 86.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
524.0, 1002.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
193.0, 565.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
212.48731964313836, 563.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
205.0, 602.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
208.51605885390313, 647.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
189.0, 653.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
201.0, 686.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
324.0, 509.5867182289346

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
669.0, 774.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
670.0, 905.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back