1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15178705.csml convertedTime:2009.07.01.10:45

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Endogenous ligands of Toll-like receptors.
Authors Tsan MF, Gao B.
Affiliation Office of Research Oversight, Department of Veterans Affairs, 50 Irving Street,NW, Washington, DC 20422, USA. min-fu.tsan2@med.va.gov
Abstract Extensive work has suggested that a number of endogenous molecules such as heatshock proteins (hsp) may be potent activators of the innate immune systemcapable of inducing proinflammatory cytokine production by themonocyte-macrophage system and the activation and maturation of dendritic cells.The cytokine-like effects of these endogenous molecules are mediated via theToll-like receptor (TLR) signal-transduction pathways in a manner similar tolipopolysaccharide (LPS; via TLR4) and bacterial lipoproteins (via TLR2).However, recent evidence suggests that the reported cytokine effects of hsp maybe a result of the contaminating LPS and LPS-associated molecules. The reasonsfor previous failure to recognize the contaminant(s) being responsible for theputative TLR ligands of hsp include failure to use highly purified hsp free ofLPS contamination; failure to recognize the heat sensitivity of LPS; and failureto consider contaminant(s) other than LPS. Whether other reported putativeendogenous ligands of TLR2 and TLR4 are a result of contamination ofpathogen-associated molecular patterns is not clear. It is essential thatefforts should be directed to conclusively determine whether the reportedputative endogenous ligands of TLRs are a result of the endogenous molecules orof contaminant(s), before exploring further the implication and therapeuticpotential of these putative TLR ligands.
PMID 15178705
Model Abstract

Entity

MO000000058:NF-kappaB MO000000077:MAPKs MO000000212:TRAF6{active} MO000000213:IRAK MO000016573:MyD88 MO000016660:IFNbeta MO000016882:LPS MO000019394:TLR4 MO000019396:TLR1 MO000019397:TLR2 MO000019398:TLR3 MO000019422:TLR6 MO000022224:dsRNA MO000041125:TRIF MO000041132:TRAM MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000042006:TLR8(h) MO000042012:TLR9 MO000042032:PGN MO000042126:TLR7 e1: e10: e11:TLR2:Lipoproteins e12:TLR2:PGN e13:LPS:TLR4 e14:Diacyl Lipopeptides e15:TLR2:TLR6:Diacyl Lipopeptides e16:ssRNA e17:TLR7:ssRNA e18:Imidazoquinolines e19:TLR7:Imidazoquinolines e2: e20:TLR8:Imidazoquinolines e21:Resiquimod e22:TLR8:Resiquimod e23:CpGDNA e24:TLR9:CpGDNA e25:TLR9:CpGDNA:MyD88 e26:TLR2:PGN:MyD88 e27:TLR2:Lipoproteins:MyD88 e28:TLR2:TLR6:Diacyl Lipopeptides:MyD88 e29:TLR2:TLR1:Triacyl lipopeptides:MyD88 e3: e30:LPS:TLR4:MyD88 e31:TLR7:ssRNA:MyD88 e32:TLR7:Imidazoquinolines:MyD88 e33:TLR8:Imidazoquinolines:MyD88 e34:TLR8:Resiquimod:MyD88 e35:TLR9:CpGDNA:MyD88:IRAK e36:TLR2:Lipoproteins:MyD88:IRAK e37:TLR2:PGN:MyD88:IRAK e38:TLR7:Imidazoquinolines:MyD88:IRAK e39:TLR8:Resiquimod:MyD88:IRAK e4: e40:TLR8:Imidazoquinolines:MyD88:IRAK e41:TLR2:TLR6:Diacyl Lipopeptides:MyD88:IRAK e42:TLR2:TLR1:Triacyl lipopeptides:MyD88:IRAK e43:TLR7:ssRNA:MyD88:IRAK e44:LPS:TLR4:MyD88:IRAK e45:TRAF6 e46:NF-kappaB{active} e47:MAPKs{active} e48:IRF3 e5:TLR1:TLR2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR2:TLR6 e60: e61: e62: e63:LPS:TLR4:TRIF e64:LPS:TLR4:TRAM e65:Immunologically relevant genes e7:Triacyl Lipopeptides e8:TLR2:TLR1:Triacyl lipopeptides e9:Lipoproteins

Process

p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p6 p7 p8 p9
Model Detail
453.0, 701.0
22.0, 22.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45 p49

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
595.0, 767.0
26.0, 26.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
504.0, 480.0
23.0, 23.0

TRAF6{active}

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34 p35 p36 p37 p38 p39 p40 p41 p43 p44

p45 p46

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
584.0, 440.0
23.0, 23.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p25 p26 p27 p28 p29 p30 p31 p32 p33

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
584.0, 360.0
23.0, 23.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p15 p16 p17 p18 p19 p20 p21 p22 p23

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1073.0, 1065.0
22.0, 22.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52 p56

--

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
1049.0, 53.0
21.0, 21.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
950.0, 130.0
19.0, 19.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
368.0, 124.0
23.0, 23.0

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false
InterProIPR003016
TRANSPATHMO000019396

--

Go back
319.0, 127.0
25.0, 25.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p5 p57 p2

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
809.0, 129.0
22.0, 22.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
283.0, 127.0
25.0, 25.0

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
740.0, 44.0
32.0, 32.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
947.0, 583.0
26.0, 26.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50 p53

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
913.0, 937.0
21.0, 21.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
1000.0, 992.0
24.0, 24.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

p51

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
844.0, 120.0
24.0, 24.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

p49 p50

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
996.0, 436.0
24.0, 24.0

TLR8(h)

--

MO000042006

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12

true true true true

csml-variable:Double

m155646

10

false

infinite

0

unit false false false
Affymetrix220832_at
EnsemblENSG00000101916
HGNCTLR8
OMIM300366
ProteomeHumanPSD/TLR8
RefSeqNM_016610
TRANSPATHMO000042006
UnigeneHs.272410
UniProtQ9NR97

--

Go back
211.0, 495.0
26.0, 26.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p14

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
72.0, 352.0
23.0, 23.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
995.0, 211.0
25.0, 25.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p10

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
194.53193123967282, 106.39227216912252
850.47749993678, 1234.8933299082032

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
195.03358606460435, 159.93735570873565
801.5390748222632, 1127.5400978548798

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
212.5, 293.0
23.605130453847842, 45.68734926551195

TLR2:Lipoproteins

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p16

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
212.5, 351.0
22.028283271212448, 42.63538697654022

TLR2:PGN

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p15

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1005.5, 108.0
20.478623108967334, 39.636044727033564

LPS:TLR4

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p19 p53 p55

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
116.94280908326323, 79.10092514718247
45.4920100925147, 25.77880571909167

Diacyl Lipopeptides

--

e14

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
208.5, 199.0
22.00109625082219, 42.582766937075206

TLR2:TLR6:Diacyl Lipopeptides

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p17

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1065.0, 120.5
45.85836439377331, 23.6934882701162

ssRNA

--

e16

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
996.5, 258.0
23.12256084192063, 44.753343565007675

TLR7:ssRNA

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p20

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1071.0, 368.0
41.98486122792263, 23.791421362489483

Imidazoquinolines

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p10 p11

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
997.5, 312.0
21.110721333041, 40.85946064459548

TLR7:Imidazoquinolines

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p21

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
194.53193123967282, 106.39227216912252
850.47749993678, 1234.8933299082032

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
996.5, 490.0
22.266169699627273, 43.09581232185924

TLR8:Imidazoquinolines

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p22

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1049.0, 613.0
37.74600504625735, 21.389402859545832

Resiquimod

--

e21

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
999.5, 543.0
17.861872396404294, 34.57136592852444

TLR8:Resiquimod

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p23

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
86.0, 617.5
60.0, 13.0

CpGDNA

--

e23

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
216.5, 539.0
22.082657311992985, 42.7406270554703

TLR9:CpGDNA

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
212.5, 588.0
23.09010827674803, 32.218755734997245

TLR9:CpGDNA:MyD88

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

p24

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
210.5, 401.0
27.848596072673896, 38.858506147917055

TLR2:PGN:MyD88

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p26

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
212.5, 448.0
23.58726371811343, 32.91246100201872

TLR2:Lipoproteins:MyD88

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p25

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
211.0, 243.0
25.500000000000004, 42.50000000000001

TLR2:TLR6:Diacyl Lipopeptides:MyD88

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p30

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
573.0, 110.0
21.970588235294116, 36.61764705882353

TLR2:TLR1:Triacyl lipopeptides:MyD88

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p31

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
211.54148123840835, 123.40182216785814
816.4583999393088, 1200.8742299107328

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
703.5, 119.0
24.778858506147923, 34.57515140392733

LPS:TLR4:MyD88

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p33

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
892.5, 104.0
23.61093778674986, 32.94549458616262

TLR7:ssRNA:MyD88

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p32

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
998.5, 381.0
26.688566709487983, 37.23986052486696

TLR7:Imidazoquinolines:MyD88

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p27

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
997.5, 700.0
28.59827491282805, 39.904569645806575

TLR8:Imidazoquinolines:MyD88

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p29

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
998.5, 637.0
26.814828408882367, 37.41603964030097

TLR8:Resiquimod:MyD88

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p28

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
214.0, 647.0
20.73529411764706, 34.55882352941176

TLR9:CpGDNA:MyD88:IRAK

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p36

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
213.0, 714.0
21.88235294117647, 36.470588235294116

TLR2:Lipoproteins:MyD88:IRAK

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p25

p35

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
217.0, 786.0
21.617647058823533, 36.029411764705884

TLR2:PGN:MyD88:IRAK

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

p34

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1001.0, 765.0
22.5, 37.50000000000001

TLR7:Imidazoquinolines:MyD88:IRAK

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

p41

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1001.0, 825.0
22.58823529411764, 37.647058823529406

TLR8:Resiquimod:MyD88:IRAK

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

p43

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
243.00914873606936, 153.16853466564524
753.5230649439873, 1141.3408049151574

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1001.0, 893.0
22.852941176470587, 38.08823529411764

TLR8:Imidazoquinolines:MyD88:IRAK

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p44

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
245.0, 122.0
21.970588235294116, 36.61764705882353

TLR2:TLR6:Diacyl Lipopeptides:MyD88:IRAK

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p37

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
428.0, 111.0
24.79411764705882, 41.32352941176471

TLR2:TLR1:Triacyl lipopeptides:MyD88:IRAK

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

p38

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1002.0, 168.0
19.58823529411765, 32.647058823529406

TLR7:ssRNA:MyD88:IRAK

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p40

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
750.0, 107.0
20.82352941176471, 34.70588235294117

LPS:TLR4:MyD88:IRAK

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p39

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
644.0, 480.0
23.0, 23.0

TRAF6

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34 p35 p36 p37 p38 p39 p40 p41 p43 p44

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
541.0, 777.0
22.0, 22.0

NF-kappaB{active}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p45 p49

p48

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
451.0, 791.0
26.0, 26.0

MAPKs{active}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46

p47

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
597.0, 1088.0
46.86851211072664, 24.996539792387544

IRF3

--

e48

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p51 p54

p52 p56

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
522.0, 124.0
28.79005524861878, 31.988950276243095

TLR1:TLR2

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
319.0, 825.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
369.29367619468036, 835.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
325.06992643728904, 830.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
325.93705878547314, 831.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
319.0, 825.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
319.0, 825.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
325.93705878547314, 831.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
658.9158804881849, 998.4264696368292
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
582.6082338479803, 1119.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
319.0, 825.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
204.0, 150.0
32.76795580110497, 36.40883977900552

TLR2:TLR6

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p57

p8

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
428.7511016961721, 1012.6637213250546
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
428.25867587120234, 991.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
449.43298634490145, 1050.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
999.5, 1167.0
24.30537713341897, 33.91447972104973

LPS:TLR4:TRIF

--

e63

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p53

p54

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1000.5, 1112.0
23.63461185538631, 32.97852817030648

LPS:TLR4:TRAM

--

e64

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p55

p56

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
493.0, 968.0
45.36332179930796, 24.193771626297583

Immunologically relevant genes

--

e65

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p47 p48

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
613.0, 59.0
45.69386038687974, 25.89318755256518

Triacyl Lipopeptides

--

e7

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false false false

--

Go back
633.5, 105.0
20.01644376233282, 38.74150405612804

TLR2:TLR1:Triacyl lipopeptides

--

e8

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p18

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false

--

Go back
128.0, 258.5
31.96216542563896, 19.71000201247736

Lipoproteins

--

e9

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
1084.0, 320.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m19940*m18*0.1

nodelay

--

true

0

false

PMID: 15178705,11812998 TLR7 also appears to recognize several synthetic compounds that are structurally related to nucleic acids such as imidazoquinolines

Go back
1081.0, 437.0
21.0, 21.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 MO000042006

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m18*m155646*0.1

nodelay

--

true

0

false

PMID: 15178705,12032557 In human, but not in mouse, TLR8 also appears to recognize the imidazoquinoline, resiquimod (R-848)

Go back
1058.0, 550.0
20.0, 20.0

p11

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042006 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m155646*m21*0.1

nodelay

--

true

0

false

PMID: 15178705,12032557 In human, but not in mouse, TLR8 also appears to recognize the imidazoquinoline, resiquimod (R-848)

Go back
104.0, 548.0
23.0, 23.0

p3

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m19828*m23*0.1

nodelay

--

true

0

false

PMID: 15178705,12077222,10549626,11607032,11323673,11431423, 15034168,11130078 Since then, TLRs have been shown to recognize and mediate signals for a wide range of microbial components: TLR1 (in association with TLR2, TLR1/2) for triacyl lipopeptides; TLR2 for lipoproteins and peptidoglycans; TLR3 for double-stranded RNA; TLR5 for flagellin; TLR6 (in association with TLR2, TLR2/6) for diacyl lipopeptides; TLR7 for single-stranded RNA, and TLR9 for nonmethylated CpG DNA

Go back
462.0, 394.0
20.0, 20.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 MO000016573

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m19828*m1572*0.1

nodelay

--

true

0

false

PMID: 15178705 Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains

Go back
466.0, 306.0
20.0, 20.0

p14

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000016573

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m12*m1572*0.1

nodelay

--

true

0

false

PMID: 15178705 Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains

Go back
466.0, 346.0
20.0, 20.0

p14

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 MO000016573

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m11*m1572*0.1

nodelay

--

true

0

false

PMID: 15178705 Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains

Go back
461.0, 269.0
22.0, 22.0

p14

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000016573

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m15*m1572*0.1

nodelay

--

true

0

false

PMID: 15178705 Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains

Go back
585.0, 245.0
22.0, 22.0

p14

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e8 MO000016573

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m8*m1572*0.1

nodelay

--

true

0

false

PMID: 15178705 Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains

Go back
677.0, 261.0
22.0, 22.0

p14

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e13

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m1572*m13*0.1

nodelay

--

true

0

false

PMID: 15178705 Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains

Go back
369.0, 37.0
22.0, 22.0

p57

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000019396

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3964*m3963*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386 TLR1 and TLR6 form heterodimers with TLR2

Go back
841.0, 293.0
21.0, 21.0

p14

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000016573

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m17*m1572*0.1

nodelay

--

true

0

false

PMID: 15178705 Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains

Go back
845.0, 337.0
21.0, 21.0

p14

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e19

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m1572*m19*0.1

nodelay

--

true

0

false

PMID: 15178705 Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains

Go back
837.0, 521.0
21.0, 21.0

p14

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e20

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m1572*m20*0.1

nodelay

--

true

0

false

PMID: 15178705 Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains

Go back
776.0, 548.0
23.0, 23.0

p14

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e22

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m1572*m22*0.1

nodelay

--

true

0

false

PMID: 15178705 Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains

Go back
598.0, 650.0
20.0, 20.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 MO000000213

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m25*m184*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
548.0, 592.0
23.0, 23.0

p24

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000000213

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m27*m184*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
388.0, 440.0
23.0, 23.0

p24

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 e26

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m184*m26*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
885.0, 441.0
22.0, 22.0

p24

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 e32

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m184*m32*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
621.0, 581.0
22.0, 22.0

p24

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 e34

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m184*m34*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
753.0, 673.0
22.0, 22.0

p24

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 e33

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m184*m33*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
524.0, 60.0
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 e7

e8

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m5*m7*0.1

nodelay

--

true

0

false

PMID: 15178705,12077222,10549626,11607032,11323673,11431423, 15034168,11130078 Since then, TLRs have been shown to recognize and mediate signals for a wide range of microbial components: TLR1 (in association with TLR2, TLR1/2) for triacyl lipopeptides; TLR2 for lipoproteins and peptidoglycans; TLR3 for double-stranded RNA; TLR5 for flagellin; TLR6 (in association with TLR2, TLR2/6) for diacyl lipopeptides; TLR7 for single-stranded RNA, and TLR9 for nonmethylated CpG DNA

Go back
373.0, 297.0
21.0, 21.0

p24

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e28 MO000000213

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m28*m184*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
529.0, 217.0
21.0, 21.0

p24

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 e29

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m184*m29*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
825.0, 173.0
22.0, 22.0

p24

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 e31

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m184*m31*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
745.0, 369.0
22.0, 22.0

p24

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 e30

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m184*m30*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
361.0, 693.0
21.0, 21.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e37 e45

MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m37*m45*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
317.0, 641.0
21.0, 21.0

p34

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 e45

MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m36*m45*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
341.0, 549.0
21.0, 21.0

p34

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e35 e45

MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m35*m45*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
397.0, 401.0
21.0, 21.0

p34

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e41 e45

MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m41*m45*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
505.0, 253.0
21.0, 21.0

p34

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e42 e45

MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m42*m45*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
645.0, 213.0
21.0, 21.0

p34

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44 e45

MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m44*m45*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
132.0, 304.0
23.0, 23.0

p3

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e9 MO000019397

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m9*m3964*0.1

nodelay

--

true

0

false

PMID: 15178705,12077222,10549626,11607032,11323673,11431423, 15034168,11130078 Since then, TLRs have been shown to recognize and mediate signals for a wide range of microbial components: TLR1 (in association with TLR2, TLR1/2) for triacyl lipopeptides; TLR2 for lipoproteins and peptidoglycans; TLR3 for double-stranded RNA; TLR5 for flagellin; TLR6 (in association with TLR2, TLR2/6) for diacyl lipopeptides; TLR7 for single-stranded RNA, and TLR9 for nonmethylated CpG DNA

Go back
809.0, 233.0
21.0, 21.0

p34

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e43 e45

MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m43*m45*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
757.0, 577.0
21.0, 21.0

p34

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e38 e45

MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m38*m45*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
625.0, 745.0
21.0, 21.0

p34

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e39 e45

MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m39*m45*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
713.0, 805.0
21.0, 21.0

p34

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e40 e45

MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m40*m45*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
489.0, 649.0
21.0, 21.0

p34

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000212 MO000000058

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m183*m46*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
561.0, 709.0
21.0, 21.0

p34

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000212 MO000000077

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m183*m69*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
470.0, 890.0
19.0, 19.0

p47

p47

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e47

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c164 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
534.0, 886.0
19.0, 19.0

p47

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e46

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c165 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386,12893815,12900270,14751757 The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes

Go back
789.0, 441.0
21.0, 21.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000041446 MO000000058

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m19314*m46*0.1

nodelay

--

true

0

false

PMID: 15178705,11607032 Conversely, the TLR3 ligand, double-stranded RNA is able to induce NF-{kappa}B activation in MyD88 knockout (KO) mice, suggesting that TLR3 signaling is independent of MyD88

Go back
136.0, 352.0
23.0, 23.0

p3

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 MO000042032

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m3964*m155701*0.1

nodelay

--

true

0

false

PMID: 15178705,12077222,10549626,11607032,11323673,11431423, 15034168,11130078 Since then, TLRs have been shown to recognize and mediate signals for a wide range of microbial components: TLR1 (in association with TLR2, TLR1/2) for triacyl lipopeptides; TLR2 for lipoproteins and peptidoglycans; TLR3 for double-stranded RNA; TLR5 for flagellin; TLR6 (in association with TLR2, TLR2/6) for diacyl lipopeptides; TLR7 for single-stranded RNA, and TLR9 for nonmethylated CpG DNA

Go back
813.0, 397.0
22.0, 22.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 15178705,12471095,12855817 In addition to the common MyD88-mediated signaling pathway, a MyD88-independent pathway has been identified that involves a third TIR-containing adaptor molecule, TIR domain-containing adaptor-inducing interferon-? (IFN-?; TRIF), which is essential for the TLR3 and TLR4 signaling, leading to the induction of transcription factor, IFN regulatory factor 3, and the subsequent production of IFN-? and the activation and maturation of DCs

Go back
693.0, 957.0
22.0, 22.0

p51

p51

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

MO000041437

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c140 : 1

m19305*0.1

nodelay

--

true

0

false

PMID: 15178705,12471095,12855817 In addition to the common MyD88-mediated signaling pathway, a MyD88-independent pathway has been identified that involves a third TIR-containing adaptor molecule, TIR domain-containing adaptor-inducing interferon-? (IFN-?; TRIF), which is essential for the TLR3 and TLR4 signaling, leading to the induction of transcription factor, IFN regulatory factor 3, and the subsequent production of IFN-? and the activation and maturation of DCs

Go back
841.0, 1065.0
21.0, 21.0

p52

p52

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e48

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c152 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 15178705,12471095,12855817 In addition to the common MyD88-mediated signaling pathway, a MyD88-independent pathway has been identified that involves a third TIR-containing adaptor molecule, TIR domain-containing adaptor-inducing interferon-? (IFN-?; TRIF), which is essential for the TLR3 and TLR4 signaling, leading to the induction of transcription factor, IFN regulatory factor 3, and the subsequent production of IFN-? and the activation and maturation of DCs

Go back
729.0, 409.0
22.0, 22.0

p50

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000041125

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m13*m18998*0.1

nodelay

--

true

0

false

PMID: 15178705,12471095,12855817 In addition to the common MyD88-mediated signaling pathway, a MyD88-independent pathway has been identified that involves a third TIR-containing adaptor molecule, TIR domain-containing adaptor-inducing interferon-? (IFN-?; TRIF), which is essential for the TLR3 and TLR4 signaling, leading to the induction of transcription factor, IFN regulatory factor 3, and the subsequent production of IFN-? and the activation and maturation of DCs

Go back
609.0, 1177.0
22.0, 22.0

p51

p54

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e63

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c142 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 15178705,12471095,12855817 In addition to the common MyD88-mediated signaling pathway, a MyD88-independent pathway has been identified that involves a third TIR-containing adaptor molecule, TIR domain-containing adaptor-inducing interferon-? (IFN-?; TRIF), which is essential for the TLR3 and TLR4 signaling, leading to the induction of transcription factor, IFN regulatory factor 3, and the subsequent production of IFN-? and the activation and maturation of DCs

Go back
689.0, 493.0
22.0, 22.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e13 MO000041132

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m13*m19005*0.1

nodelay

--

true

0

false

PMID: 15178705,14556004 Recently, a fourth TIR-containing adaptor molecule, TRIF-related adaptor molecule (TRAM), has been shown to be involved specifically in TLR4- but not TLR3-mediated, MyD88-independent IFN-? production

Go back
840.0, 1120.0
20.0, 20.0

p56

p56

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e64 e48

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c167 : 1
stoichiometry:c163 : 1

m65*m49*0.1

nodelay

--

true

0

false

PMID: 15178705,14556004 Recently, a fourth TIR-containing adaptor molecule, TRIF-related adaptor molecule (TRAM), has been shown to be involved specifically in TLR4- but not TLR3-mediated, MyD88-independent IFN-? production

Go back
284.0, 32.0
24.0, 24.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019422 MO000019397

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1
stoichiometry:c157 : 1

m3987*m3964*0.1

nodelay

--

true

0

false

PMID: 15178705,12524386 TLR1 and TLR6 form heterodimers with TLR2

Go back
808.0, 48.0
23.0, 23.0

p3

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 15178705,12077222,10549626,11607032,11323673,11431423, 15034168,11130078 Since then, TLRs have been shown to recognize and mediate signals for a wide range of microbial components: TLR1 (in association with TLR2, TLR1/2) for triacyl lipopeptides; TLR2 for lipoproteins and peptidoglycans; TLR3 for double-stranded RNA; TLR5 for flagellin; TLR6 (in association with TLR2, TLR2/6) for diacyl lipopeptides; TLR7 for single-stranded RNA, and TLR9 for nonmethylated CpG DNA

Go back
980.0, 52.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019394 MO000016882

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m3961*m155666*0.1

nodelay

--

true

0

false

PMID: 15178705,9851930 In 1998, TLR4 was identified as the signal transducer for lipopolysaccharide (LPS), a major cell-wall component of Gram-negative bacteria

Go back
128.0, 156.0
23.0, 23.0

p3

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 e6

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m14*m6*0.1

nodelay

--

true

0

false

PMID: 15178705,12077222,10549626,11607032,11323673,11431423, 15034168,11130078 Since then, TLRs have been shown to recognize and mediate signals for a wide range of microbial components: TLR1 (in association with TLR2, TLR1/2) for triacyl lipopeptides; TLR2 for lipoproteins and peptidoglycans; TLR3 for double-stranded RNA; TLR5 for flagellin; TLR6 (in association with TLR2, TLR2/6) for diacyl lipopeptides; TLR7 for single-stranded RNA, and TLR9 for nonmethylated CpG DNA

Go back
1076.0, 212.0
23.0, 23.0

p3

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000042126

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m16*m19940*0.1

nodelay

--

true

0

false

PMID: 15178705,12077222,10549626,11607032,11323673,11431423, 15034168,11130078 Since then, TLRs have been shown to recognize and mediate signals for a wide range of microbial components: TLR1 (in association with TLR2, TLR1/2) for triacyl lipopeptides; TLR2 for lipoproteins and peptidoglycans; TLR3 for double-stranded RNA; TLR5 for flagellin; TLR6 (in association with TLR2, TLR2/6) for diacyl lipopeptides; TLR7 for single-stranded RNA, and TLR9 for nonmethylated CpG DNA

Go back
144.0, 278.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
239.0, 716.5732438904543

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
388.40586318390854, 501.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
379.0, 509.60245808999866

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
235.0, 665.8739464471706

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
345.1926307064737, 498.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
338.0, 507.1790546266568

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
235.0, 574.0403268549408

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
369.807537202421, 495.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
362.0, 500.06953323108155

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
266.0, 159.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
160.83185994120439, 152.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
425.61271593083774, 417.45897461482815

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
418.0, 419.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
452.0, 152.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
526.1983112638025, 280.8098592153017

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.0, 274.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
671.7931034482758, 134.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
656.0, 242.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
525.7152841149846, 234.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
837.6326747000592, 187.0

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
664.0, 260.6790483253175

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.0, 316.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
533.1994868664364, 253.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
784.238753854053, 601.0077889680515

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
667.0, 501.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.4717770319409, 498.85876686439474

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
653.7899196116239, 759.8213051486332

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
637.5934021147817, 503.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
524.3104235544095, 510.2829318197008

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
163.07263670565638, 152.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
741.5894663844041, 821.5298221281347

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
658.0, 503.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.3238075830109, 509.7308757220066

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.7636205865145, 503.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
472.0, 676.6233495239067

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
504.0, 670.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
519.0, 503.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
582.0886031430172, 736.8762871041653

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
483.3269656037119, 729.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
466.0, 817.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
95.0, 364.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.2789412031452, 979.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
545.550416732923, 799.0

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
620.0, 1121.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
803.3796862498524, 144.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
475.0, 464.8961662978551

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.7574246014838, 462.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
825.9420170915832, 144.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
836.6983281033682, 425.47500679791926

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.7910245570642, 419.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
722.9436722517244, 969.9476661633636

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
159.0, 365.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
296.0, 64.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
302.8435825769178, 63.4775689985616

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
862.0, 1076.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.5043422689236, 139.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
757.2438413325883, 434.0014443327365

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
740.0, 431.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
638.9995300096197, 1184.0

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
235.20085861637287, 56.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
714.1504153958606, 140.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.6337001596239, 522.1271469151371

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
772.0, 60.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.1941984722218, 515.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
867.9991953329289, 1128.0

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
860.0, 1080.7935291779863

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.0, 909.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
522.5298221281347, 905.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
644.0, 1077.8479875014102

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
644.0, 1103.0

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
820.0, 79.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
826.0, 71.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
964.0, 82.3806390171605

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1011.0, 64.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
996.0, 75.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
140.0, 105.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
159.0, 168.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
151.0, 175.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1088.0, 144.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.0, 224.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1027.999862405834, 235.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1018.0, 236.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1093.0, 350.974522228289

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1027.0, 332.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1092.0, 392.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.0, 448.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1026.9998495597224, 458.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1014.0, 460.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1068.0, 578.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1025.0, 560.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
134.1893248090344, 514.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
116.0, 579.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
127.0, 560.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
339.0, 66.1130864831044

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
237.0, 420.6294119933627

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.7521162826164, 375.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
243.99999379739376, 414.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
235.0, 319.75690151519495

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
493.2701752102633, 324.3383457598148

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
245.39608044298504, 320.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
236.0, 318.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
493.9305281915463, 358.05200884173576

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
243.34819358944267, 360.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
231.0, 222.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
380.0, 67.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.42282042930947, 292.7694211108734

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.9844206278631, 265.49902628924144

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
602.7518517376798, 144.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
596.0, 275.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.7316151395659, 154.9664759641612

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
607.0, 288.88135505504476

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
706.9999949578356, 144.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 161.83608150167737

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
869.9999949176249, 284.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
607.0, 309.0489571142346

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
391.0, 55.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
855.0, 144.69959740789122

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
607.0, 349.7363565559253

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
873.9553806775862, 333.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
855.7024211534792, 358.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
607.0, 379.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
865.9337547378442, 513.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.9700202393324, 542.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
607.0, 383.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
807.0, 560.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.0, 571.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 91.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
236.0, 606.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
597.0, 463.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
242.9995143457702, 660.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
236.0, 469.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.8121079572823, 463.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
242.9999961909522, 615.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
419.0, 452.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
238.0, 423.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
246.99999865706155, 463.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
607.0, 452.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.0, 72.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
914.3072133659795, 406.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.0, 463.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
599.0, 463.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
650.8887426902205, 595.3295633747563

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.0, 603.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0, 463.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
782.9188841750425, 687.1363421237729

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.0, 695.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
237.0, 267.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.6186498798444, 319.49371491842066

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
535.7204096687287, 31.690535633260367

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.64325908535926, 156.67041681849847

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.922188542689, 245.76564171246363

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
548.2394092661764, 147.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
458.76958130522837, 149.54183467475883

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
607.0, 200.9644766695917

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
852.8442155145995, 131.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.0, 184.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
607.0, 388.27851937152826

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
719.0, 154.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
756.0, 149.99875827010757

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back