1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15189145.csml convertedTime:2009.07.01.10:46

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Lysophospholipid receptors: signaling and biology.
Authors Ishii I, Fukushima N, Ye X, Chun J.
Affiliation Department of Molecular Genetics, National Institute of Neuroscience, NCNP,Kodaira, Tokyo 187-8502, Japan. isao@ncnp.go.jp
Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affectfundamental cellular functions, which include proliferation, differentiation,survival, migration, adhesion, invasion, and morphogenesis. These functionsinfluence many biological processes that include neurogenesis, angiogenesis,wound healing, immunity, and carcinogenesis. In recent years, identification ofmultiple cognate G protein-coupled receptors has provided a mechanisticframework for understanding how LPs play such diverse roles. Generation of LPreceptor-null animals has allowed rigorous examination of receptor-mediatedphysiological functions in vivo and has identified new functions for LP receptorsignaling. Efforts to develop LP receptor subtype-specific agonists/antagonistsare in progress and raise expectations for a growing collection of chemicaltools and potential therapeutic compounds. The rapidly expanding literature onthe LP receptors is herein reviewed.
PMID 15189145
Model Abstract

Entity

MO000000003:Ras family MO000000023:JNK MO000000048:AKT MO000000057:Rac MO000000058:NF-kappaB MO000000132:PLC MO000000318:Gi MO000000321:Gq MO000000322:G12/13 MO000016894:MAPK MO000017265:IL-12 MO000017369:Rho MO000022492:PPARgamma (NR1C3) e1: e10: e100:S1P:GPR63 e101:GPR63 e102:dihydro S1P: GPR63 e103:di hydro S1P e104:e104 e105:dioleoylphosphatidic acid e106:IL-12 e107:LPA:PPARG e108:FTY720-P e109:FTY720-P:S1P e11:LPA:albumin e110:FTY720-P:S1P3 e111:FTY720-P:S1P4 e112:FTY720-P:S1P5 e12:LDLs e13:LPA:LDLs e14:S1P e15:S1P:albumin e16:S1P:LDLs e17:LPA1 e18:LPA:LPA1 e19:LPA:LPA1:Gi e2: e20:LPA:LPA1:Gq e21:LPA:LPA1:G12/13 e22:MAPK{active} e23:PLC{active} e24:AKT{active} e25:Rho{active} e26:Adenylate cyclase e27:adenylate cyclase e28:LPA2 e29:LPA:LPA2 e3: e30:LPA:LPA2:Gi e31:LPA:LPA2:Gq e32:LPA:LPA2:G12/13 e33:JNK{active} e34:LPA3 e35:LPA:LPA3 e36:LPA:LPA3:Gi e37:LPA4 e38:LPA:LPA3:Gq e39:LPA:LPA4 e4: e40:S1P e41:S1P:S1P1 e42:S1P:S1P1{p} e43:S1P:S1P1:Gi e44:Rac{active} e45:S1P2 e46:S1P:S1P2 e47:S1P2:S1P:Gi e48:S1P:S1P2:Gq e49:S1P2:S1P:G12/13 e5:albumin e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPA e60: e61: e62: e63:S1P3 e64:S1P:S1P3 e65:S1P:S1P3:Gi e66:S1P:S1P3:Gq e67:S1P:S1P3:G12/13 e68:S1P4 e69:S1P:S1P4 e7: e70:S1P:S1P4:Gi e71:S1P:S1P4:G12/13 e72:S1P4:phytosphingosine 1-phosphate e73:phytosphingosine 1-phosphate e74:S1P5 e75:S1P:S1P5 e76:S1P:S1P5:Gi e77:S1P:S1P5:G12/13 e78:G2A e79:G2A:LPA e8: e80:SPC e81:G2A:SPC e82:LPA:G2A:G12/13 e83:Ras family{active} e84:LPA:G2A:Gi e85:LPA:G2A:Gq e86:NF-kappaB e87:LPA:G2A:G13 e88:G13 e89:OGR1 e9: e90:SPC:OGR1 e91:SPC:OGR1:Gi e92:SPC:OGR1:Gq e93:GPR4 e94:SPC:GPR4 e95:LPC:GPR4 e96:LPC e97:SPC:GPR4:Gi e98:GPR12 e99:S1P:GPR12

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90
Model Detail
767.0, 859.0
42.0, 42.0

Ras family

--

MO000000003

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65

true true true true

csml-variable:Double

m86

10

false

infinite

0

unit false false false
TRANSPATHMO000000003

--

Go back
482.0, 606.0
36.0, 36.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
829.0, 385.0
30.0, 30.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p27

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
549.0, 741.0
38.0, 38.0

Rac

--

MO000000057

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p47 p64

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSPATHMO000000057

--

Go back
1101.0, 1217.0
38.0, 38.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p69 p70

true true true true

csml-variable:Double

m90

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
849.0, 469.0
29.0, 29.0

PLC

--

MO000000132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p30 p11 p20 p38 p45 p53

true true true true

csml-variable:Double

m119

10

false

infinite

0

unit false false false
TRANSPATHMO000000132

--

Go back
1236.0, 348.0
40.0, 40.0

Gi

--

MO000000318

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p23 p36 p17 p29 p42 p51 p58 p66 p73 p78

true true true true

csml-variable:Double

m253

10

false

infinite

0

unit false false false
TRANSPATHMO000000318

--

Go back
1242.0, 458.0
35.0, 35.0

Gq

--

MO000000321

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p24 p37 p31 p43 p68 p74

true true true true

csml-variable:Double

m256

10

false

infinite

0

unit false false false
TRANSPATHMO000000321

--

Go back
1228.0, 536.0
40.0, 40.0

G12/13

--

MO000000322

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p25 p32 p44 p52 p59 p62

true true true true

csml-variable:Double

m257

10

false

infinite

0

unit false false false
TRANSPATHMO000000322

--

Go back
689.0, 429.0
38.0, 38.0

MAPK

--

MO000016894

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p10 p19 p39 p46 p54 p67 p75 p79

true true true true

csml-variable:Double

m1812

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
98.0, 1250.0
60.0, 60.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p86

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
1044.0, 744.0
40.0, 40.0

Rho

--

MO000017369

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p40 p48 p56 p63

true true true true

csml-variable:Double

m2203

10

false

infinite

0

unit false false false
TRANSPATHMO000017369

--

Go back
1003.0, 643.0
42.0, 42.0

PPARgamma (NR1C3)

--

MO000022492

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p84

true true true true

csml-variable:Double

m6775

10

false

infinite

0

unit false false false
InterProIPR003077
TRANSPATHMO000022492

--

Go back
251.28407718872364, 63.90861031075064
1100.4868286801, 1735.197474167938

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
261.8871911586767, 90.4303002298188
1066.7087351998161, 1629.4858342401608

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
716.5, 1718.0
31.0, 60.0

S1P:GPR63

--

e100

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p81

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
782.5, 1725.0456942003516
35.07029876977153, 53.95430579964851

GPR63

--

e101

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p81 p82 p83

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
660.5, 1718.0
31.0, 60.0

dihydro S1P: GPR63

--

e102

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p82

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
838.0, 1919.0
60.0, 34.0

di hydro S1P

--

e103

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p82

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
600.5, 1718.578601183951
30.18438938829204, 58.42139881604911

e104

--

e104

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p83

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
655.0, 1911.1009251471826
58.05719091673675, 32.89907485281749

dioleoylphosphatidic acid

--

e105

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p83

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
686.0, 1268.0
60.0, 32.0

IL-12

--

e106

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p85

p86

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
1079.0, 565.5046257359124
50.28595458368377, 28.49537426408747

LPA:PPARG

--

e107

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p84

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
22.0, 955.0
60.0, 34.0

FTY720-P

--

e108

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p87 p88 p89 p90

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
272.5, 942.0
31.0, 60.0

FTY720-P:S1P

--

e109

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p87

--

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
1699.0, 384.69470142977286
41.126997476871324, 23.305298570227073

LPA:albumin

--

e11

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p1

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
276.5, 1014.0
31.0, 60.0

FTY720-P:S1P3

--

e110

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p88

--

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
272.5, 1090.0
31.0, 60.0

FTY720-P:S1P4

--

e111

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p89

--

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
276.5, 1174.0
31.0, 60.0

FTY720-P:S1P5

--

e112

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p90

--

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
1543.0, 530.6999999999998
34.400000000000006, 25.799999999999997

LDLs

--

e12

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p2 p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1619.0, 452.69470142977286
41.126997476871324, 23.305298570227073

LPA:LDLs

--

e13

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p2

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1394.0, 183.0
60.0, 34.0

S1P

--

e14

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p3 p4 p14 p28 p41 p49 p57 p80 p81

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1575.0, 136.69470142977286
41.126997476871324, 23.305298570227073

S1P:albumin

--

e15

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p3

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1747.0, 272.69470142977286
41.126997476871324, 23.305298570227073

S1P:LDLs

--

e16

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p4

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1288.5, 214.0
39.0, 60.0

LPA1

--

e17

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p5

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1288.5, 302.0
31.0, 60.0

LPA:LPA1

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p6 p7 p8 p85 p86

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1288.5, 385.61772802349054
38.25729491649844, 53.38227197650946

LPA:LPA1:Gi

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p12 p15 p9

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
251.28407718872364, 63.90861031075064
1100.4868286801, 1735.197474167938

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1292.5, 485.6177280234906
38.25729491649844, 53.38227197650946

LPA:LPA1:Gq

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p18 p21 p55

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1284.5, 561.6177280234906
38.25729491649844, 53.38227197650946

LPA:LPA1:G12/13

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
677.0, 769.0
38.0, 38.0

MAPK{active}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9 p10 p19 p39 p46 p54 p67 p75 p79

--

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
809.0, 785.0
29.0, 29.0

PLC{active}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12 p30 p11 p20 p38 p45 p53

--

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSPATHMO000000132

--

Go back
1093.0, 401.0
30.0, 30.0

AKT{active}

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15 p27

p16

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
1044.0, 948.0
40.0, 40.0

Rho{active}

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18 p40 p48 p56 p63

--

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000017369

--

Go back
441.0, 267.17999999999984
45.760000000000005, 34.32

Adenylate cyclase

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p21 p55

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
472.0, 485.5
48.0, 36.0

adenylate cyclase

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

p21 p55

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1288.5, 146.0
39.0, 60.0

LPA2

--

e28

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p22

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1264.5, 74.0
31.0, 60.0

LPA:LPA2

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p22

p23 p24 p25

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
273.29381376232556, 87.80940196595658
1056.4673555328964, 1687.3958908575287

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1211.5, 68.7839970636814
33.83813543769499, 47.2160029363186

LPA:LPA2:Gi

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p23

p21 p27 p55

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1146.5, 87.72692237107725
34.59570563406129, 48.27307762892274

LPA:LPA2:Gq

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

p30 p33

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1068.5, 81.5186272710589
38.32831712240778, 53.481372728941096

LPA:LPA2:G12/13

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p25

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
478.0, 786.0
36.0, 36.0

JNK{active}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33

--

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1290.5, 640.4130052724078
35.481546572934974, 54.58699472759226

LPA3

--

e34

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p35

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1292.5, 722.0
31.0, 60.0

LPA:LPA3

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p35

p36 p37

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1289.5, 794.1503028078547
36.442282987704175, 50.849697192145356

LPA:LPA3:Gi

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p36

p10 p11

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1291.5, 934.3848857644991
32.89982425307557, 50.615114235500876

LPA4

--

e37

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p13

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1292.5, 862.2415122040743
31.3602495870802, 43.758487795925866

LPA:LPA3:Gq

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane

--

p37

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
1292.5, 1006.0
31.0, 60.0

LPA:LPA4

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
314.0118264234893, 129.63578736256645
975.0313302105691, 1603.7431200643077

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
973.5, 83.5659050966608
37.332161687170476, 57.43409490333919

S1P

--

e40

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p14 p87

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
912.5, 94.0
31.0, 60.0

S1P:S1P1

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

p16 p17

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
844.5, 74.0
31.0, 60.0

S1P:S1P1{p}

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

p26

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
799.5, 93.0
33.25417507799597, 46.40117452743623

S1P:S1P1:Gi

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p17

p21 p19 p20 p55

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
557.0, 925.0
38.0, 38.0

Rac{active}

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26 p47 p64

--

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
TRANSPATHMO000000057

--

Go back
715.5, 87.22847100175744
32.35149384885764, 49.77152899824254

S1P2

--

e45

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p28

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
656.5, 82.0
31.0, 60.0

S1P:S1P2

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

p29 p31 p32

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
591.5, 84.77298586896677
33.84602679390714, 47.22701413103322

S1P2:S1P:Gi

--

e47

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p21 p26 p38 p39 p40 p47 p64

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
536.5, 86.97026977427049
30.121306661772792, 42.0297302257295

S1P:S1P2:Gq

--

e48

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p31

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
467.5, 85.14039273261147
32.1493852082951, 44.85960726738852

S1P2:S1P:G12/13

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1582.5, 321.90259609579397
27.193399074260416, 44.09740390420609

albumin

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1 p3

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
484.23127804374576, 1064.594903147679
598.4655482016115, 589.3744047387133

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
548.8700150934544, 1078.562219724372
349.94074885531836, 571.2211889870074

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
492.03250492905534, 1072.4612966400846
582.8630944309926, 573.6416177539015

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
493.146965912671, 1073.6715110235323
580.6341724637609, 571.2211889870074

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
484.23127804374576, 1064.594903147679
598.4655482016115, 589.3744047387133

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
484.23127804374576, 1064.594903147679
598.4655482016115, 589.3744047387133

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
493.146965912671, 1073.6715110235323
580.6341724637609, 571.2211889870074

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
921.0999836210854, 1306.6377798370881
37.38883918024405, 36.75481736961283

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
823.027417062907, 1476.067793519676
105.87379344348805, 104.0784369764464

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
484.23127804374576, 1064.594903147679
598.4655482016115, 589.3744047387133

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1454.0, 267.0
60.0, 34.0

LPA

--

e6

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p1 p2 p5 p22 p35 p13 p60 p84

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
625.286240421005, 1326.5080185727645
18.95252455879257, 9.90932557736857

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
624.6533619793197, 1296.956064769512
64.87004027272309, 126.79849945814075

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
651.8671349717798, 1379.4266335227744
10.126055066961635, 10.996075833768298

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
419.5, 82.13884007029878
33.0597539543058, 50.86115992970123

S1P3

--

e63

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p41 p88

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
344.5, 86.0
31.0, 60.0

S1P:S1P3

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41

p42 p43 p44

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
279.5, 100.07028812626169
33.63296017617912, 46.92971187373831

S1P:S1P3:Gi

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p42

p45 p46 p47 p48

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
276.5, 170.2305010093595
31.368140943292357, 43.769498990640486

S1P:S1P3:Gq

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
276.5, 242.9702697742705
30.121306661772795, 42.02973022572951

S1P:S1P3:G12/13

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p44

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
277.5, 305.25483304042166
29.084358523725832, 44.745166959578206

S1P4

--

e68

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p49 p50 p89

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
279.5, 379.286998465249
25.16838412628809, 48.71300153475115

S1P:S1P4

--

e69

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p49

p51 p52

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
265.7428689659319, 70.89118211971854
1079.2347237266972, 1660.6391985044236

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
277.5, 519.9722884933016
29.403193246467247, 41.02771150669848

S1P:S1P4:Gi

--

e70

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p51

p53 p54 p55 p56

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
280.5, 582.8030831345203
30.957790420260604, 43.19691686547992

S1P:S1P4:G12/13

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
284.5, 453.6149967112476
22.93225169918877, 44.38500328875247

S1P4:phytosphingosine 1-phosphate

--

e72

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p50

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
30.0, 487.0
60.0, 34.0

phytosphingosine 1-phosphate

--

e73

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p50

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
276.5, 660.4428822495606
30.91212653778559, 47.55711775043937

S1P5

--

e74

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p57 p90

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
277.5, 723.8283271212454
29.538697654023238, 57.17167287875466

S1P:S1P5

--

e75

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p57

p58 p59

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
278.5, 795.0662506881997
35.06918700679023, 48.93374931180034

S1P:S1P5:Gi

--

e76

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p58

p21 p55

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
275.5, 865.0723068452928
32.91484676087356, 45.92769315470729

S1P:S1P5:G12/13

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p59

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1291.5, 1090.2601054481547
33.63093145869947, 51.73989455184534

G2A

--

e78

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p60 p61

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
1293.5, 1166.986406489805
29.973689980267483, 58.013593510195136

G2A:LPA

--

e79

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p60

p62 p66 p68 p71

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
269.59854677318737, 100.19985928486899
1035.3227303841643, 1632.4496939830965

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
1558.0, 1159.0
60.0, 34.0

SPC

--

e80

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p61 p72 p76

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1294.5, 1245.6167507125633
27.064678798509096, 52.38324928743697

G2A:SPC

--

e81

cso30:c:Complex

cso30:i:CC_Extracellular

--

p61

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
1289.5, 1329.465590016517
37.649660488162965, 52.53440998348321

LPA:G2A:G12/13

--

e82

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p62

p63 p64 p65

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
711.0, 975.0
42.0, 42.0

Ras family{active}

--

e83

cso30:c:Protein

cso30:i:CC_CellComponent

--

p65

--

true true true true

csml-variable:Double

m87

10

false

infinite

0

unit false false false
TRANSPATHMO000000003

--

Go back
1291.5, 1396.5747843641036
33.988071205725824, 47.42521563589649

LPA:G2A:Gi

--

e84

cso30:c:Complex

cso30:i:CC_Extracellular

--

p66

p67

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1291.5, 1448.686915030281
33.19104422829878, 46.31308496971922

LPA:G2A:Gq

--

e85

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p68

p69

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
1101.0, 1393.0
38.0, 38.0

NF-kappaB

--

e86

cso30:c:Protein

cso30:i:CC_CellComponent

--

p69 p70

--

true true true true

csml-variable:Double

m91

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1282.5, 1519.3415305560654
34.87190310148651, 48.65846944393466

LPA:G2A:G13

--

e87

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p71

p70

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
1208.0, 1476.8344737371704
48.10625880458844, 29.66552626282954

G13

--

e88

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p71

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1292.5, 1588.267135325132
31.026362038664324, 47.73286467486819

OGR1

--

e89

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p72

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
279.88035425920225, 129.5085364500195
1030.595914209835, 1611.0405253013898

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1288.5, 1646.0
31.0, 60.0

SPC:OGR1

--

e90

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p72

p73 p74

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1280.5, 1717.8049183336393
38.123141860891906, 53.19508166636081

SPC:OGR1:Gi

--

e91

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p73

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1199.5, 1724.8741053404294
33.05689117269225, 46.12589465957056

SPC:OGR1:Gq

--

e92

cso30:c:Complex

cso30:i:CC_Cytosol

--

p74

p75

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
1139.5, 1727.2284710017577
32.35149384885764, 49.77152899824253

GPR4

--

e93

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p76 p77

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1102.5, 1725.5904406928305
27.07827230870423, 52.40955930716948

SPC:GPR4

--

e94

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p76

p78

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
1034.5, 1725.0118395088796
27.89388292041219, 53.98816049112037

LPC:GPR4

--

e95

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p77

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1358.0, 1891.0
60.0, 34.0

LPC

--

e96

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p77

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
976.5, 1729.4156726004771
31.95210130299138, 44.58432739952285

SPC:GPR4:Gi

--

e97

cso30:c:Complex

cso30:i:CC_Cytosol

--

p78

p79

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
903.5, 1726.1388400702988
33.0597539543058, 50.86115992970123

GPR12

--

e98

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p80

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
857.5, 1723.802017101513
29.55229116421837, 57.197982898487176

S1P:GPR12

--

e99

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p80

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1513.0, 381.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 e6

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m6*0.1

nodelay

--

true

0

false

PMID: 15189145 Serum LPA is bound to albumin, low-density lipoproteins, or other proteins, which possibly protect LPA from rapid degradation.

Go back
735.0, 619.0
25.0, 25.0

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016894 e36

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m1812*m37*0.1

nodelay

--

true

0

false

PMID: 15189145, 11040035, 10488122, 10727522 LPA3 can mediate pleiotropic LPA-induced signaling that includes PLC activation, Ca2+ mobilization, AC inhibition/activation, and MAPK activation.

Go back
784.0, 696.0
23.0, 23.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000132 e36

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c32 : 1

m119*m37*0.1

nodelay

--

true

0

false

PMID: 15189145, 11040035, 10488122, 10727522 LPA3 can mediate pleiotropic LPA-induced signaling that includes PLC activation, Ca2+ mobilization, AC inhibition/activation, and MAPK activation.

Go back
817.0, 669.0
21.0, 21.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000132 e19

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c40 : 1
stoichiometry:c39 : 1

m119*m19*0.1

nodelay

--

true

0

false

PMID: 15189145, 11093753 Through activation of these G proteins, LPA induces a range of cellular responses through LPA1: cell proliferation, serum-response element (SRE) activation, MAPK activation, AC inhibition, PLC activation, Ca2+ mobilization, Akt activation, and Rho activation.

Go back
1455.0, 1075.0
25.0, 25.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e37 e6

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m38*m6*0.1

nodelay

--

true

0

false

PMID: 15189145, 12724320 The orphan receptor, p2y9/GPR23, is a functional high-affinity LPA receptor (Kd 45 nM)that is now classified as LPA4.

Go back
942.0, 10.0
27.0, 27.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e40 e14

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m41*m14*0.1

nodelay

--

true

0

false

PMID: 15189145 S1P1 (EDG-1/LPB1) was the first identified S1P receptor that was initially isolated as an orphan GPCR in human endothelial cells, and it was later shown to encode a high-affinity (Kd 8 nM) S1P receptor.

Go back
993.0, 429.0
21.0, 21.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000048 e19

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c49 : 1
stoichiometry:c46 : 1

m45*m19*0.1

nodelay

--

true

0

false

PMID: 15189145, 11093753 Through activation of these G proteins, LPA induces a range of cellular responses through LPA1: cell proliferation, serum-response element (SRE) activation, MAPK activation, AC inhibition, PLC activation, Ca2+ mobilization, Akt activation, and Rho activation.

Go back
871.0, 179.0
26.0, 26.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e41 e24

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c47 : 1
stoichiometry:c44 : 1

m42*m24*0.1

nodelay

--

true

0

false

PMID: 15189145, 11583630 Akt-mediated phosphorylation of S1P1 is required for Rac activation, cortical actin assembly, and cell migration, but not for Gi/o-dependent signaling in endothelial cells.

Go back
855.0, 7.0
26.0, 26.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e41 MO000000318

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c51 : 1
stoichiometry:c50 : 1

m42*m253*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 The S1P1 receptor primarily couples with PTX-sensitive Gi/o proteins and mediates S1P induced MAPK activation, AC inhibition, PLC activation, Calcium mobilization, cell aggregation, Rac (and often Rho) activation, and cell migration.

Go back
1052.0, 868.5
23.0, 23.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017369 e20

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c59 : 1
stoichiometry:c55 : 1

m2203*m20*0.1

nodelay

--

true

0

false

PMID: 15189145, 11093753 Through activation of these G proteins, LPA induces a range of cellular responses through LPA1: cell proliferation, serum-response element (SRE) activation, MAPK activation, AC inhibition, PLC activation, Ca2+ mobilization, Akt activation, and Rho activation.

Go back
668.0, 600.0
23.0, 23.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016894 e43

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1

m1812*m44*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 The S1P1 receptor primarily couples with PTX-sensitive Gi/o proteins and mediates S1P induced MAPK activation, AC inhibition, PLC activation, Calcium mobilization, cell aggregation, Rac (and often Rho) activation, and cell migration.

Go back
1504.0, 452.0
23.0, 23.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m6*m12*0.1

nodelay

--

true

0

false

PMID: 15189145 Serum LPA is bound to albumin, low-density lipoproteins, or other proteins, which possibly protect LPA from rapid degradation.

Go back
750.0, 670.0
19.0, 19.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000132 e43

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c63 : 1
stoichiometry:c60 : 1

m119*m44*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 The S1P1 receptor primarily couples with PTX-sensitive Gi/o proteins and mediates S1P induced MAPK activation, AC inhibition, PLC activation, Calcium mobilization, cell aggregation, Rac (and often Rho) activation, and cell migration.

Go back
403.0, 383.0
25.0, 25.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 e20 e30 e43 e76 e47

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c64 : 1
stoichiometry:c82 : 1
stoichiometry:c52 : 1
stoichiometry:c178 : 1
stoichiometry:c280 : 1
stoichiometry:c62 : 1

m26*m63*0.1

nodelay

--

true

0

false

PMID: 15189145, 11093753 Through activation of these G proteins, LPA induces a range of cellular responses through LPA1: cell proliferation, serum-response element (SRE) activation, MAPK activation, AC inhibition, PLC activation, Ca2+ mobilization, Akt activation, and Rho activation. PMID: 15189145 Importantly, many LPA-induced responses, which include cell proliferation, AC inhibition, PLC activation, Calcium; mobilization, JNK and Akt activation, and stress fiber formation,are absent or severely reduced in double-null MEFs. PMID: 15189145, 11264467, 12069812, 12069815, 12069818 The S1P1 receptor primarily couples with PTX-sensitive Gi/o proteins and mediates S1P induced MAPK activation, AC inhibition, PLC activation, Calcium mobilization, cell aggregation, Rac (and often Rho) activation, and cell migration. PMID: 15189145 S1P5 can couple with Gi/o and G12/13 and it mediates S1P induced AC inhibition.

Go back
1411.0, 23.5
25.5, 25.5

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e28 e6

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m28*m6*0.1

nodelay

--

true

0

false

Go back
1235.0, 11.0
25.0, 25.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e29 MO000000318

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m29*m253*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 11093753 As with LPA1, LPA2 couples with three types of G proteins, Gi/o, Gq, and G12/13, to mediate LPA-induced cellular signaling

Go back
1080.0, 8.0
23.0, 23.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e29 MO000000321

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m29*m256*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 11093753 As with LPA1, LPA2 couples with three types of G proteins, Gi/o, Gq, and G12/13, to mediate LPA-induced cellular signaling.

Go back
995.0, 11.0
25.0, 25.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000322 e29

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m257*m29*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 11093753 As with LPA1, LPA2 couples with three types of G proteins, Gi/o, Gq, and G12/13, to mediate LPA-induced cellular signaling

Go back
576.0, 844.0
23.0, 23.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000057 e42 e47

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c81 : 1
stoichiometry:c123 : 1
stoichiometry:c80 : 1

m46*m43*0.1

nodelay

--

true

0

false

PMID: 15189145, 11583630 Akt-mediated phosphorylation of S1P1 is required for Rac activation, cortical actin assembly, and cell migration, but not for Gi/o-dependent signaling in endothelial cells. PMID: 15189145, 11094076 S1P2 inhibits Rac activity and prevents cell migration.

Go back
944.0, 348.0
23.0, 23.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000048 e30

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c83 : 1
stoichiometry:c79 : 1

m45*m30*0.1

nodelay

--

true

0

false

PMID: 15189145 Importantly, many LPA-induced responses, which include cell proliferation, AC inhibition, PLC activation, Calcium; mobilization, JNK and Akt activation, and stress fiber formation,are absent or severely reduced in double-null MEFs.

Go back
688.0, 12.0
23.0, 23.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e45 e14

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m48*m14*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467 S1P2 was later identified by many groups as a high-affinity (Kd 20?27 nM) S1P receptor and it is also encoded on a single exon.

Go back
612.0, 8.0
23.0, 23.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e46 MO000000318

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m49*m253*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 It couples with Gi/o, Gq, G12/13, and possibly Gs, and it can mediate S1P-induced cell proliferation, cell survival, cell rounding, SRE activation, MAPK activation, AC activation,PLC activation, Ca2 mobilization, and Rho activation.

Go back
1585.0, 216.5
22.5, 22.5

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e14 e5

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m14*m5*0.1

nodelay

--

true

0

false

PMID: 15189145, 12069820 S1P in serum is bound to albumin or lipoproteins, and its concentration is estimated to be 0.5?0.8 microM in human serum and 0.2?0.4 microM in human plasma.

Go back
884.0, 652.0
23.0, 23.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000132 e31

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c95 : 1
stoichiometry:c94 : 1

m119*m31*0.1

nodelay

--

true

0

false

PMID: 15189145 Importantly, many LPA-induced responses, which include cell proliferation, AC inhibition, PLC activation, Calcium; mobilization, JNK and Akt activation, and stress fiber formation,are absent or severely reduced in double-null MEFs.

Go back
408.0, 4.0
23.0, 23.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e46 MO000000321

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m49*m256*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 It couples with Gi/o, Gq, G12/13, and possibly Gs, and it can mediate S1P-induced cell proliferation, cell survival, cell rounding, SRE activation, MAPK activation, AC activation,PLC activation, Calcium mobilization, and Rho activation.

Go back
527.0, 7.0
25.0, 25.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e46 MO000000322

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m49*m257*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 It couples with Gi/o, Gq, G12/13, and possibly Gs, and it can mediate S1P-induced cell proliferation, cell survival, cell rounding, SRE activation, MAPK activation, AC activation,PLC activation, Ca2 mobilization, and Rho activation.

Go back
486.0, 710.0
19.0, 19.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e31

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c106 : 1
stoichiometry:c102 : 1

m33*m31*0.1

nodelay

--

true

0

false

PMID: 15189145 Importantly, many LPA-induced responses, which include cell proliferation, AC inhibition, PLC activation, Calcium mobilization, JNK and Akt activation, and stress fiber formation,are absent or severely reduced in double-null MEFs.

Go back
1499.0, 655.0
25.0, 25.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e34 e6

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m35*m6*0.1

nodelay

--

true

0

false

Go back
1423.0, 831.0
25.0, 25.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000318 e35

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m253*m36*0.1

nodelay

--

true

0

false

PMID: 15189145, 11040035 The LPA3 receptor is distinct from LPA1 and LPA2 in its ability to couple with Gi/o and Gq but not G12/13.

Go back
1401.0, 965.0
21.0, 21.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000321 e35

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m256*m36*0.1

nodelay

--

true

0

false

PMID: 15189145, 11040035 The LPA3 receptor is distinct from LPA1 and LPA2 in its ability to couple with Gi/o and Gq but not G12/13.

Go back
845.0, 685.0
21.0, 21.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000132 e47

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c107 : 1
stoichiometry:c105 : 1

m119*m63*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 It couples with Gi/o, Gq, G12/13, and possibly Gs, and it can mediate S1P-induced cell proliferation, cell survival, cell rounding, SRE activation, MAPK activation, AC activation,PLC activation, Ca2 mobilization, and Rho activation.

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710.0, 626.0
19.0, 19.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016894 e47

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c119 : 1
stoichiometry:c118 : 1

m1812*m63*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 It couples with Gi/o, Gq, G12/13, and possibly Gs, and it can mediate S1P-induced cell proliferation, cell survival, cell rounding, SRE activation, MAPK activation, AC activation,PLC activation, Ca2 mobilization, and Rho activation.

Go back
1546.0, 266.0
27.0, 27.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e14 e12

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m14*m12*0.1

nodelay

--

true

0

false

PMID: 15189145, 12069820 S1P in serum is bound to albumin or lipoproteins, and its concentration is estimated to be 0.5?0.8 microM in human serum and 0.2?0.4 microM in human plasma.

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1017.0, 877.0
21.0, 21.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017369 e47

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c122 : 1
stoichiometry:c121 : 1

m2203*m63*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 It couples with Gi/o, Gq, G12/13, and possibly Gs, and it can mediate S1P-induced cell proliferation, cell survival, cell rounding, SRE activation, MAPK activation, AC activation,PLC activation, Ca2 mobilization, and Rho activation.

Go back
245.0, 9.0
21.0, 21.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e63 e14

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c126 : 1
stoichiometry:c125 : 1

m66*m14*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467 Like S1P2, S1P3 is a high-affinity (Kd 23?26 nM) S1P receptor and is encoded on a single exon.

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186.0, 98.0
19.0, 19.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e64 MO000000318

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m67*m253*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 The S1P3 receptor couples with Gi/o, Gq, G12/13, and possibly Gs, and it induces cell proliferation, cell survival, cell rounding, MAPK activation,SRE activation, AC activation/inhibition, PLC activation, Ca2 mobilization, Rho activation, Rac activation, and cell migration

Go back
152.0, 184.0
23.0, 23.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e64 MO000000321

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m67*m256*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 The S1P3 receptor couples with Gi/o, Gq, G12/13, and possibly Gs, and it induces cell proliferation, cell survival, cell rounding, MAPK activation,SRE activation, AC activation/inhibition, PLC activation, Ca2 mobilization, Rho activation, Rac activation, and cell migration

Go back
132.0, 292.0
23.0, 23.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e64 MO000000322

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m67*m257*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 The S1P3 receptor couples with Gi/o, Gq, G12/13, and possibly Gs, and it induces cell proliferation, cell survival, cell rounding, MAPK activation,SRE activation, AC activation/inhibition, PLC activation, Ca2 mobilization, Rho activation, Rac activation, and cell migration

Go back
744.0, 704.0
23.0, 23.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000132 e65

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c138 : 1
stoichiometry:c137 : 1

m119*m68*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 The S1P3 receptor couples with Gi/o, Gq, G12/13, and possibly Gs, and it induces cell proliferation, cell survival, cell rounding, MAPK activation,SRE activation, AC activation/inhibition, PLC activation, Ca2 mobilization, Rho activation, Rac activation, and cell migration.

Go back
625.0, 553.0
21.0, 21.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016894 e65

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c141 : 1
stoichiometry:c140 : 1

m1812*m68*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 The S1P3 receptor couples with Gi/o, Gq, G12/13, and possibly Gs, and it induces cell proliferation, cell survival, cell rounding, MAPK activation,SRE activation, AC activation/inhibition, PLC activation, Ca2 mobilization, Rho activation, Rac activation, and cell migration.

Go back
537.0, 849.0
21.0, 21.0

p47

p47

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000057 e65 e47

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c144 : 1
stoichiometry:c274 : 1
stoichiometry:c143 : 1

m46*m68*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 The S1P3 receptor couples with Gi/o, Gq, G12/13, and possibly Gs, and it induces cell proliferation, cell survival, cell rounding, MAPK activation,SRE activation, AC activation/inhibition, PLC activation, Ca2 mobilization, Rho activation, Rac activation, and cell migration.

Go back
969.0, 865.0
21.0, 21.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017369 e65

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c147 : 1
stoichiometry:c146 : 1

m2203*m68*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467, 12069812, 12069815, 12069818 The S1P3 receptor couples with Gi/o, Gq, G12/13, and possibly Gs, and it induces cell proliferation, cell survival, cell rounding, MAPK activation,SRE activation, AC activation/inhibition, PLC activation, Ca2 mobilization, Rho activation, Rac activation, and cell migration.

Go back
151.0, 343.0
25.0, 25.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e68 e14

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c150 : 1
stoichiometry:c149 : 1

m71*m14*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467 It was found to encode a high-affinity (Kd 13?63 nM) receptor for S1P.

Go back
1436.0, 348.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 e6

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m17*m6*0.1

nodelay

--

true

0

false

PMID: 15189145, 8922387 LPA1 (previously called VZG-1/EDG-2/mrec1.3) was the first identified, high affinity receptor for LPA.

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183.0, 463.0
25.0, 25.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e68 e73

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c153 : 1
stoichiometry:c152 : 1

m71*m76*0.1

nodelay

--

true

0

false

PMID: 15189145, 12270137 phytosphingosine 1-phosphate (4D-hydroxysphinganine 1-phosphate) has a 50-fold higher affinity for S1P4

Go back
85.0, 453.0
21.0, 21.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e69 MO000000318

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c156 : 1

m72*m253*0.1

nodelay

--

true

0

false

PMID: 15189145, 11443127, 10679247, 10753843, 12761884 S1P4 couples with Gi/o, G12/13, and possibly Gs, and it mediates S1P-induced MAPK activation, PLC activation, Ca2 mobilization, AC activation,Rho activation, cytoskeletal rearrangement.

Go back
172.0, 632.0
23.0, 23.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e69 MO000000322

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m72*m257*0.1

nodelay

--

true

0

false

PMID: 15189145, 11443127, 10679247, 10753843, 12761884 S1P4 couples with Gi/o, G12/13, and possibly Gs, and it mediates S1P-induced MAPK activation, PLC activation, Ca2 mobilization, AC activation,Rho activation, cytoskeletal rearrangement.

Go back
941.0, 621.0
21.0, 21.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000132 e70

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c162 : 1
stoichiometry:c161 : 1

m119*m73*0.1

nodelay

--

true

0

false

PMID: 15189145, 11443127, 10679247, 10753843, 12761884 S1P4 couples with Gi/o, G12/13, and possibly Gs, and it mediates S1P-induced MAPK activation, PLC activation, Ca2 mobilization, AC activation,Rho activation, cytoskeletal rearrangement.

Go back
748.0, 524.0
23.0, 23.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016894 e70

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c165 : 1
stoichiometry:c164 : 1

m1812*m73*0.1

nodelay

--

true

0

false

PMID: 15189145, 11443127, 10679247, 10753843, 12761884 S1P4 couples with Gi/o, G12/13, and possibly Gs, and it mediates S1P-induced MAPK activation, PLC activation, Ca2 mobilization, AC activation,Rho activation, cytoskeletal rearrangement.

Go back
525.0, 342.0
25.0, 25.0

p55

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 e70 e43 e30 e20 e76

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c168 : 1
stoichiometry:c276 : 1
stoichiometry:c277 : 1
stoichiometry:c278 : 1
stoichiometry:c279 : 1
stoichiometry:c167 : 1

m26*m73*0.1

nodelay

--

true

0

false

PMID: 15189145, 11443127, 10679247, 10753843, 12761884 S1P4 couples with Gi/o, G12/13, and possibly Gs, and it mediates S1P-induced MAPK activation, PLC activation, Ca2 mobilization, AC activation,Rho activation, cytoskeletal rearrangement.

Go back
1141.0, 853.0
21.0, 21.0

p56

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017369 e70

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c171 : 1
stoichiometry:c170 : 1

m2203*m73*0.1

nodelay

--

true

0

false

PMID: 15189145, 11443127, 10679247, 10753843, 12761884 S1P4 couples with Gi/o, G12/13, and possibly Gs, and it mediates S1P-induced MAPK activation, PLC activation, Ca2 mobilization, AC activation,Rho activation, cytoskeletal rearrangement.

Go back
135.0, 703.0
25.0, 25.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e74 e14

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c174 : 1
stoichiometry:c173 : 1

m77*m14*0.1

nodelay

--

true

0

false

PMID: 15189145, 11264467 It was later found to encode a high-affinity S1P receptor (Kd 2?10 nM)

Go back
202.0, 810.0
19.0, 19.0

p58

p58

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e75 MO000000318

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c177 : 1
stoichiometry:c176 : 1

m78*m253*0.1

nodelay

--

true

0

false

PMID: 15189145 S1P5 can couple with Gi/o and G12/13 and it mediates S1P induced AC inhibition.

Go back
202.0, 870.0
19.0, 19.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e75 MO000000322

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c181 : 1

m78*m257*0.1

nodelay

--

true

0

false

PMID: 15189145 S1P5 can couple with Gi/o and G12/13 and it mediates S1P induced AC inhibition.

Go back
1428.0, 416.0
23.0, 23.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 MO000000318

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m18*m253*0.1

nodelay

--

true

0

false

PMID: 15189145, 9600933, 11040035 LPA1 couples with three types of G proteins, Gi/o, Gq, and G12/13..

Go back
1381.0, 1141.0
21.0, 21.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e78 e6

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c184 : 1
stoichiometry:c183 : 1

m81*m6*0.1

nodelay

--

true

0

false

PMID: 15189145, 11474113 G2A has properties of a high-affinity LPC receptor (Kd 65 nM) and low-affinity SPC receptor (Kd 230 nM).

Go back
1400.0, 1220.0
23.0, 23.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e78 e80

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c187 : 1
stoichiometry:c186 : 1

m81*m83*0.1

nodelay

--

true

0

false

PMID: 15189145, 11474113 G2A has properties of a high-affinity LPC receptor (Kd 65 nM) and low-affinity SPC receptor (Kd 230 nM).

Go back
1442.0, 1334.0
27.0, 27.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e79 MO000000322

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c190 : 1
stoichiometry:c188 : 1

m82*m257*0.1

nodelay

--

true

0

false

PMID: 15189145, 10951580, 11050239 G2A appears to couple with G12/13 and mediates the activation of small GTPases (Rho, Rac, and Ras), stress fiber formation that requires G13 and Rho, and SRE activation.

Go back
1088.0, 868.0
23.0, 23.0

p63

p63

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017369 e82

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c193 : 1
stoichiometry:c192 : 1

m2203*m85*0.1

nodelay

--

true

0

false

PMID: 15189145, 10951580, 11050239 G2A appears to couple with G12/13 and mediates the activation of small GTPases (Rho, Rac, and Ras), stress fiber formation that requires G13 and Rho, and SRE activation.

Go back
616.0, 840.0
23.0, 23.0

p64

p64

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000057 e82 e47

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c196 : 1
stoichiometry:c275 : 1
stoichiometry:c195 : 1

m46*m85*0.1

nodelay

--

true

0

false

PMID: 15189145, 10951580, 11050239 G2A appears to couple with G12/13 and mediates the activation of small GTPases (Rho, Rac, and Ras), stress fiber formation that requires G13 and Rho, and SRE activation.

Go back
791.0, 931.0
25.0, 25.0

p65

p65

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000003 e82

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c199 : 1
stoichiometry:c198 : 1

m86*m85*0.1

nodelay

--

true

0

false

PMID: 15189145, 10951580, 11050239 G2A appears to couple with G12/13 and mediates the activation of small GTPases (Rho, Rac, and Ras), stress fiber formation that requires G13 and Rho, and SRE activation.

Go back
1453.0, 1290.0
25.0, 25.0

p66

p66

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e79 MO000000318

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c201 : 1
stoichiometry:c202 : 1

m82*m253*0.1

nodelay

--

true

0

false

PMID: 15189145 It also mediates LPC-induced Ca2 mobilization and MAPK activation in a pertussis toxin (PTX)-sensitive manner, suggesting coupling to Gi/o.

Go back
791.0, 507.0
25.0, 25.0

p67

p67

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016894 e84

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c205 : 1
stoichiometry:c204 : 1

m1812*m88*0.1

nodelay

--

true

0

false

PMID: 15189145 It also mediates LPC-induced Ca2 mobilization and MAPK activation in a pertussis toxin (PTX)-sensitive manner, suggesting coupling to Gi/o.

Go back
1424.0, 1416.0
23.0, 23.0

p68

p68

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e79 MO000000321

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c207 : 1
stoichiometry:c208 : 1

m82*m256*0.1

nodelay

--

true

0

false

PMID: 15189145, 12586833 G2A couples with Gq and G13 for NF-kappaB activation.

Go back
1108.0, 1316.0
23.0, 23.0

p69

p69

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c211 : 1
stoichiometry:c210 : 1

m90*m89*0.1

nodelay

--

true

0

false

PMID: 15189145, 12586833 G2A couples with Gq and G13 for NF-kappaB activation.

Go back
1420.0, 476.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 MO000000321

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m18*m256*0.1

nodelay

--

true

0

false

PMID: 15189145, 9600933, 11040035 LPA1 couples with three types of G proteins, Gi/o, Gq, and G12/13..

Go back
1153.0, 1305.0
21.0, 21.0

p70

p70

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e87

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c217 : 1
stoichiometry:c213 : 1

m90*m92*0.1

nodelay

--

true

0

false

PMID: 15189145, 12586833 G2A couples with Gq and G13 for NF-kappaB activation.

Go back
1373.0, 1493.0
21.0, 21.0

p71

p71

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e88 e79

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c216 : 1
stoichiometry:c215 : 1

m93*m82*0.1

nodelay

--

true

0

false

PMID: 15189145, 12586833 G2A couples with Gq and G13 for NF-kappaB activation.

Go back
1464.0, 1600.0
23.0, 23.0

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e89 e80

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c220 : 1
stoichiometry:c219 : 1

m94*m83*0.1

nodelay

--

true

0

false

PMID: 15189145, 10806476 OGR1 encode a high-affinity (Kd 33 nM) receptor for SPC.

Go back
1428.0, 1676.0
23.0, 23.0

p73

p73

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e90 MO000000318

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c223 : 1
stoichiometry:c221 : 1

m95*m253*0.1

nodelay

--

true

0

false

PMID: 15189145, 10806476 OGR1 appears to couple with both Gi/o and Gq, mediating SPC-induced Ca2 mobilization via Gi/o and MAPK activation via Gq. It also mediates SPC inhibition of cell proliferation.

Go back
1511.0, 1719.0
25.0, 25.0

p74

p74

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e90 MO000000321

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c225 : 1
stoichiometry:c226 : 1

m95*m256*0.1

nodelay

--

true

0

false

PMID: 15189145, 10806476 OGR1 appears to couple with both Gi/o and Gq, mediating SPC-induced Ca2 mobilization via Gi/o and MAPK activation via Gq. It also mediates SPC inhibition of cell proliferation.

Go back
634.0, 470.0
19.0, 19.0

p75

p75

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016894 e92

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c229 : 1
stoichiometry:c228 : 1

m1812*m97*0.1

nodelay

--

true

0

false

PMID: 15189145, 10806476 OGR1 appears to couple with both Gi/o and Gq, mediating SPC-induced Ca2 mobilization via Gi/o and MAPK activation via Gq. It also mediates SPC inhibition of cell proliferation.

Go back
1144.0, 1836.0
23.0, 23.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e93 e80

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c232 : 1
stoichiometry:c231 : 1

m98*m83*0.1

nodelay

--

true

0

false

PMID: 15189145, 11535583 It was later reported to encode a high-affinity receptor for SPC (Kd 36 nM) and low-affinity receptor for LPC (Kd 159 nM).

Go back
1257.0, 1860.0
23.0, 23.0

p77

p77

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e93 e96

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c235 : 1
stoichiometry:c234 : 1

m98*m101*0.1

nodelay

--

true

0

false

PMID: 15189145, 11535583 It was later reported to encode a high-affinity receptor for SPC (Kd 36 nM) and low-affinity receptor for LPC (Kd 159 nM).

Go back
1061.0, 1857.0
26.0, 26.0

p78

p78

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e94 MO000000318

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c238 : 1
stoichiometry:c237 : 1

m99*m253*0.1

nodelay

--

true

0

false

PMID: 15189145, 11535583 GPR4 appears to couple (at least) with Gi/o to mediate cell proliferation, SRE activation, MAPK activation, Ca2 mobilization, and cell motility.

Go back
579.0, 555.0
25.0, 25.0

p79

p79

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016894 e97

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c241 : 1
stoichiometry:c240 : 1

m1812*m102*0.1

nodelay

--

true

0

false

PMID: 15189145, 11535583 GPR4 appears to couple (at least) with Gi/o to mediate cell proliferation, SRE activation, MAPK activation, Ca2 mobilization, and cell motility.

Go back
1432.0, 520.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000322 e18

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m257*m18*0.1

nodelay

--

true

0

false

PMID: 15189145, 9600933, 11040035 LPA1 couples with three types of G proteins, Gi/o, Gq, and G12/13.

Go back
893.0, 1858.0
25.0, 25.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e98 e14

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c242 : 1
stoichiometry:c244 : 1
stoichiometry:c243 : 1

m103*m14*0.1

nodelay

--

true

0

false

PMID: 15189145, 12220620 GPR12 has been reported to be a moderate-affinity S1P receptor, unresponsive to SPC

Go back
760.0, 1852.0
23.0, 23.0

p81

p81

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e101 e14

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c247 : 1
stoichiometry:c246 : 1

m106*m14*0.1

nodelay

--

true

0

false

PMID: 15189145, 12618218 A human orphan receptor GPR63 was reported to act as a low-affinity receptor for S1P, dihydro-S1P, and dioleoylphosphatidic acid.

Go back
816.0, 1848.0
23.0, 23.0

p82

p82

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e101 e103

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c248 : 1
stoichiometry:c249 : 1
stoichiometry:c250 : 1

m106*m108*0.1

nodelay

--

true

0

false

PMID: 15189145, 12618218 A human orphan receptor GPR63 was reported to act as a low-affinity receptor for S1P, dihydro-S1P, and dioleoylphosphatidic acid.

Go back
764.0, 1916.0
23.0, 23.0

p83

p83

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e105 e101

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c252 : 1
stoichiometry:c253 : 1

m110*m106*0.1

nodelay

--

true

0

false

PMID: 15189145, 12618218 A human orphan receptor GPR63 was reported to act as a low-affinity receptor for S1P, dihydro-S1P, and dioleoylphosphatidic acid.

Go back
1112.0, 640.0
23.0, 23.0

p84

p84

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 MO000022492

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c255 : 1
stoichiometry:c256 : 1

m6*m6775*0.1

nodelay

--

true

0

false

PMID: 15189145, 12502787 The nuclear hormone receptor peroxisome proliferator-activated receptor (PPARgamma) was proposed as an intracellular receptor for LPA.

Go back
700.0, 1176.0
24.0, 24.0

p85

p85

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e18

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c257 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 15189145, 11024010, 11160288 In activated T cells, LPA inhibits cell migration but activates IL-2 production/cell proliferation through LPA1.

Go back
433.0, 1265.0
30.0, 30.0

p86

p86

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e106 e18

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c261 : 1
stoichiometry:c259 : 1

m111*m18*0.1

nodelay

--

true

0

false

PMID: 15189145, 11024010, 11160288 In activated T cells, LPA inhibits cell migration but activates IL-2 production/cell proliferation through LPA1.

Go back
155.0, 959.0
25.0, 25.0

p87

p87

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e108 e40

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c262 : 1
stoichiometry:c264 : 1
stoichiometry:c263 : 1

m113*m41*0.1

nodelay

--

true

0

false

PMID: 15189145 FTY720-P can bind to each of four S1P receptors (S1P1, S1P3?S1P5) and activates them with varied potency and efficacy compared to S1P.

Go back
101.0, 1024.0
27.0, 27.0

p88

p88

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e108 e63

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c267 : 1
stoichiometry:c266 : 1

m113*m66*0.1

nodelay

--

true

0

false

PMID: 15189145 FTY720-P can bind to each of four S1P receptors (S1P1, S1P3?S1P5) and activates them with varied potency and efficacy compared to S1P.

Go back
121.0, 1109.0
21.0, 21.0

p89

p89

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e108 e68

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c270 : 1
stoichiometry:c268 : 1

m113*m71*0.1

nodelay

--

true

0

false

PMID: 15189145 FTY720-P can bind to each of four S1P receptors (S1P1, S1P3?S1P5) and activates them with varied potency and efficacy compared to S1P.

Go back
684.0, 580.0
23.0, 23.0

p9

p9

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016894 e19

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c27 : 1
stoichiometry:c26 : 1

m1812*m19*0.1

nodelay

--

true

0

false

PMID: 15189145, 11093753 Through activation of these G proteins, LPA induces a range of cellular responses through LPA1: cell proliferation, serum-response element (SRE) activation, MAPK activation, AC inhibition, PLC activation, Ca2+ mobilization, Akt activation, and Rho activation.

Go back
24.0, 1120.0
23.0, 23.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e108 e74

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c272 : 1
stoichiometry:c273 : 1
stoichiometry:c271 : 1

m113*m77*0.1

nodelay

--

true

0

false

PMID: 15189145 FTY720-P can bind to each of four S1P receptors (S1P1, S1P3?S1P5) and activates them with varied potency and efficacy compared to S1P.

Go back
1540.6981640364993, 353.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1453.0, 217.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.3525982005662, 642.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 729.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
856.2992556493805, 498.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
831.3254370185559, 706.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
510.91785191573484, 128.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
618.0, 132.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1326.0, 668.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1485.0, 301.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1560.0, 301.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1331.3833665323975, 673.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1264.0, 388.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1324.0, 763.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1333.8508095013187, 824.5377874280933

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1265.0, 493.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1322.0, 782.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1329.996429652523, 903.2955482645657

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
709.0, 467.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
700.2738595105969, 645.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
613.0, 132.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1573.0, 280.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1033.2304815589116, 784.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1033.0, 898.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
621.0, 132.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
588.1067035874378, 132.0

c123

c123

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
273.192390390806, 28.502787527989927

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.0, 29.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
273.9075400232619, 23.212769879454175

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
212.99001871102277, 108.39950093555113

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
212.76948933085248, 111.90657691630037

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
205.0, 109.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1328.0, 260.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
182.39742478779772, 122.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
182.75208218435532, 200.97616340594624

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
175.0, 193.23519241281514

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
161.04026494714114, 129.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
162.800848541954, 308.7739115044145

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.0, 270.0888664809792

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
765.3792291966664, 498.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
765.0, 727.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
313.0, 146.0

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
647.1971969835085, 467.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1457.391520848389, 301.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
639.0, 574.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
313.0, 146.0

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
551.5689290811055, 779.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
551.0, 870.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
304.0, 147.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
992.8126139128935, 784.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
989.0, 886.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
313.0, 143.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
183.82016835265864, 331.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
176.0, 360.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1327.8472364872123, 336.55591757936105

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
183.93922176676003, 204.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
208.38278102645998, 350.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
208.0, 476.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
90.0, 480.601331299634

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
113.6528581900262, 408.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
113.97304312330729, 370.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
106.0, 468.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
192.28886202485455, 428.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
202.97305373121236, 558.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
195.0, 612.6349772505464

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1320.0, 343.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.0, 498.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
839.8496861356155, 642.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
307.0, 542.0

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
719.0, 467.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
702.9567237019918, 547.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
307.0, 536.0725593735992

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
482.0, 301.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
503.19776902317903, 367.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
307.0, 369.80937899422906

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1082.0, 784.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1276.0, 375.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1086.1859646885794, 874.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
307.0, 546.0

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
167.80949648147163, 687.0

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
160.0, 719.0

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
167.41656945275713, 212.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
227.1192895849364, 764.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
221.0, 820.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
228.34264258596474, 377.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.0, 411.8475928984812

c178

c178

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
222.27194393110386, 775.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1334.9345441785347, 415.02127796357377

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
228.63516495597278, 562.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
221.0, 881.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1325.0, 1123.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1330.1057411452475, 1158.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1393.842901086895, 301.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1325.0, 1135.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1329.4667648496245, 1237.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1430.6226643280158, 1185.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1334.9891337106503, 1349.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1323.0, 1212.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1320.0, 351.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1253.0, 576.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1070.0, 784.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1074.993552273537, 891.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1108.1977655617256, 898.3330958954756

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.0, 779.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
590.932754944306, 863.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.4295071359951, 864.7604031329488

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
793.0, 901.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
759.4404466988269, 953.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.1968974718523, 959.0594922396768

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1490.0, 301.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1277.0, 477.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1323.0, 1206.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1260.0, 388.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1331.4480354359562, 1313.0

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
727.0, 462.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
706.9765266698538, 532.0

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.9063690324222, 538.981423993895

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1323.0, 1224.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1263.0, 493.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1332.56622672162, 1432.0

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1120.0, 1255.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1338.841238500708, 490.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1120.0, 1339.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1137.3571035008742, 1340.8566691342082

c211

c211

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1130.0, 1255.0

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1132.2693178820084, 1326.0

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1256.0, 1494.0

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1324.2061494509512, 1509.0

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1315.0, 1225.0

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1174.095000561587, 1332.872479203359

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1324.0, 1612.0

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1327.4906334205523, 1616.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1268.0, 533.9684350024883

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1480.9984485192067, 1193.0

c220

c220

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1326.4183890569539, 1693.0

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1320.0, 1677.0

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1259.0, 388.0

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1320.0, 1680.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1264.0, 493.0

c225

c225

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1240.6123073424637, 1744.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
660.1554175279994, 457.0

c227

c227

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
646.0, 489.0

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.2917453950623, 496.2913930256218

c229

c229

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1320.0, 354.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1156.0, 1777.0

c230

c230

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1130.0588143418104, 1785.3921346593752

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1168.3234149731381, 1193.0

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1172.0, 1769.0

c233

c233

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1069.0286672978366, 1763.8207114542085

c234

c234

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1287.6462320697756, 1877.3526867907

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.6725439384982, 1778.0

c236

c236

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1011.5823947831562, 1780.5575649483098

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1076.9623280269082, 388.0

c238

c238

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
609.5590628233351, 467.0

c239

c239

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1330.4183890569539, 537.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
598.0, 580.0

c240

c240

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
598.5594875553321, 587.5795134048367

c241

c241

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
908.8834522085988, 1777.0

c242

c242

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
882.197769023179, 1788.6921915811265

c243

c243

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.3700220579009, 217.0

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.9152391000054, 1779.0

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
744.6518879601005, 1785.547681117209

c246

c246

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.9160537502637, 217.0

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
807.0, 1779.0

c248

c248

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
837.6954753506958, 1878.095312673336

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.6351567716034, 467.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
698.4247842258704, 1763.7667753933877

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
713.0, 1928.0

c251

c251

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
779.0421384168941, 1779.0

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.3099897243529, 1770.9836451371439

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1140.5891147065072, 301.0

c254

c254

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1045.0, 653.9484864889977

c255

c255

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1110.1756560418075, 601.6984752248576

c256

c256

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
712.0, 1200.0

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
470.99871333506735, 1280.1434746786558

c258

c258

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
166.0, 1280.0

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.0, 603.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.553263706042, 354.0

c260

c260

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
467.36102316190136, 349.0

c261

c261

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
82.0, 972.0

c262

c262

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
180.0, 972.0

c263

c263

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
185.53706019264436, 131.0

c264

c264

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
68.0, 989.0

c265

c265

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
128.0, 1038.0

c266

c266

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
122.606094095854, 133.0

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
142.0, 1120.0

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
61.0, 989.0

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
714.6755537249578, 418.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
135.59077428959225, 350.0

c270

c270

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
47.0, 1135.0

c271

c271

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
37.79001267273466, 989.0

c272

c272

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
46.963661062356664, 708.0

c273

c273

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
549.3169915293158, 132.0

c274

c274

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
609.0, 132.0

c275

c275

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
553.0327407852467, 130.0

c276

c276

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
553.7383086508893, 98.0

c277

c277

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
553.9198688544556, 357.7966355276215

c278

c278

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
309.0, 370.5473733228761

c279

c279

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
712.0, 467.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.4314760493311, 132.0

c280

c280

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
704.5480149607846, 644.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1534.0, 392.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
767.5837233957394, 638.5469863480031

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
802.320059162263, 498.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
799.0, 719.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.8140373714834, 711.7148819076134

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1324.0, 973.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1468.165339353977, 301.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1331.6009911034591, 1043.4949818125858

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
963.9983134039794, 44.41688052563323

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
831.4270323854224, 498.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.2525057071977, 690.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1487.0, 301.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.9903317698602, 423.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
976.487007374633, 31.818638070450085

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.1620511210258, 37.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
897.4376015698018, 149.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
870.0613012044827, 141.72987951680997

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
859.0, 404.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.0, 421.77723610263484

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
902.6568542494924, 210.65685424949237

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
880.0040235939028, 39.92587864891303

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1021.9671456517416, 414.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1525.8745270641346, 481.99914566424286

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
831.8553499981773, 33.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
886.9588564791545, 37.33779256442572

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.27858303642535, 128.0

c52

c52

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
683.3632247871051, 467.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.0, 784.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.0, 892.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.0, 623.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.1247513071439, 139.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
768.7732180026973, 498.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1076.465413538531, 539.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1527.0, 464.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
765.0, 689.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
425.14052158620797, 301.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
425.0, 408.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
761.7945454389854, 139.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
431.9674672958189, 398.50912008073516

c64

c64

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
572.0, 779.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1328.0, 55.17025099234316

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1428.8899027126092, 56.77356210092081

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1303.217073773085, 42.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1255.9373322778883, 43.441241770650585

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1454.0, 205.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1248.2050608063405, 43.99737144727585

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1237.320059162263, 36.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1110.310492388962, 28.24910772842758

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1098.7607529591942, 38.50854467245819

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1101.0, 31.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1016.295037468384, 43.28990590350425

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1027.683852454392, 30.226749078619726

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.0, 36.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
859.0, 366.7410427608056

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
967.0, 364.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1596.0, 247.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.0930991770963, 867.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.722882663839, 134.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
431.7453167102762, 98.0

c82

c82

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
972.703219554905, 108.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.7455436233884, 42.51411939032591

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
718.7736939145029, 28.889360453598073

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
683.4323213903456, 35.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
633.7431017633522, 38.0703033307765

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
642.0075105353798, 29.859377682546935

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
613.4567140814585, 31.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1596.0, 168.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
438.47694957419213, 22.845210899913813

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
438.0172040453324, 25.841724532833013

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.0, 24.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
867.0, 498.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
835.7312732965926, 675.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
905.4881339308408, 136.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
558.5685164117394, 32.56668283863789

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.3772875439205, 33.83013494450786

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
502.31963755426915, 32.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back