1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15241548.csml convertedTime:2009.07.01.10:46

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Lipopolysaccharide-binding molecules: transporters, blockers and sensors.
Authors Chaby R.
Affiliation Endotoxin Group, UMR-8619 of the National Center for Scientific Research,Batiment 430, University of Paris-Sud, 91405, Orsay, France.richard.chaby@bbmpc.u-psud.fr
Abstract Lipopolysaccharide (LPS), a major component of the outer membrane ofGram-negative bacteria, can be beneficial to the host by activating the innateimmune system, or harmful, by inducing inflammation, disseminated intravascularcoagulation, multiple organ failure, shock and often death. On the bacteria, andin host biological fluids and cells, LPS is never free but constantly attachedto cognate-binding proteins. Understanding how LPS is transported and furtherrecognized by sensors able to deliver a signal, or by inactivating moleculesable to neutralize its biological effects, is an important goal. This reviewdescribes the large panel of peptides and proteins reported to associate withLPS, and provides information on their origin, their structure and the locationof amino acid residues involved in their interaction with LPS. A betterunderstanding of the mode of recognition of LPS by cognate proteins promptedmany laboratories to design on a rational basis synthetic molecules which can beused to detect low amounts of endotoxin, or to act as efficient blockers of invitro and in vivo responses to LPS.
PMID 15241548
Model Abstract

Entity

G010329:TNF-alpha MO000000058:NF-kappaB MO000000289:TNF-alpha MO000005766:GDF5 MO000012555:SELPLG(P-selectin) MO000016653:RP105 MO000016882:LPS MO000017075:tubulin MO000017157:CXCR4 MO000018132:sCD14 MO000018240:apo A1 MO000018926:heparin MO000019394:TLR4 MO000019420:LBP MO000021135:Hsp90 MO000021614:Hsp70 MO000022131:MD-2 MO000022200:MD-1 MO000023102:moesin MO000061423:BPI MO000064893:SLPI MO000066851:PLTP MO000069324:CETP MO000079001:hCAP18(h) MO000089774:L-selectin MO000100669:hemoglobin e1: e10: e100:Lactoferrin:Iron e101:Lactoferrin:Heparin e102:proteoglycans e103:Lactoferrin:proteoglycans e104:DNA e105:Lactoferrin:DNA e106:oligonucleotide e107:lactoferrin:oligo e108:Lactoferrin:LPS e109:HBP e11:LBP:apoA1 e110:HBP:syndecans e111:syndecans e112:glypicans e113:HBP:glypicans e114:LPS:HBP e115:Indolicidin e116:Indolicidin:LPS e117:Bac5 e118:Bac5:LPS e119:Prophenin e12:LBP:mCD14 e120:Prophenin:LPS e121:C1 inhibitor e122:LPS:C1 inhibitor e123:Lysozyme e124:Lysozyme:LPS e125:LPS:SLPI e126:Dermatan e127:Dermatan:LPS e128:Heparan e129:Dermatan:LPS e13:LBP:mCD14:LPS e130:Dextran sulfate e131:LPS:Dextran sulfate e132:Histatin e133:LPS:Histatin e134:HNP-1 e135:LPS:HNP-1 e136:SMAP-29 e137:SMAP-29:LPS e138:LPS:hCAP18 e139:MD-2:TLR4:LBP:mCD14:LPS e14:LPS:sCD14 e140:LPS e141:P2X7 e142:LPS:P2X7 e143:LPS:moesin e144:LPS:Tubulin e145:proteasome e146:LPS:proteasome e147:H1 e148:LPS:H1 e149:H2A e15:LTA e150:H2A:LPS e151:H2B e152:H2B:LPS e153:H3 e154:H3:LPS e155:H4 e156:LPS:H4 e157:NO e158:HNP-2 e159:LPS:HNP-2 e16:Phosphatidyl inositol e160:HNP-3 e161:LPS:HNP-3 e162:HNP-4 e163:LPS:HNP-4 e164:PMB e165:LPS:PMB e166:gramicidine e167:gramicidine:LPS e168:Lectins e169:LPS:lectin e17:sCD14:LTA e170:FhuA e171:ompT e172:MsbA e173:LPS:FhuA e174:LPS:ompT e175:LPS:MsbA e176:Lysosomal phosphatases e177:Lysosomal phosphatases:LPS e178:Granule acyloxyacyl hydrolase e179:Granule acyloxyacyl hydrolase:LPS e18:sCD14:phosphatidyl inositol e180:PLTP:apoA1 e181:LPS:CETP e182:PLTP:apoA1:LPS e19:MD-2:TLR4 e2: e20:LPS:MD-2 e21:MD-1:RP105 e22:MD-1:RP105:LPS e23:PGRP-LCx e24:peptidoglycan e25:PGRP-LCx:peptidoglycan e26:PGRP-LCx:LPS e27:PGRP-LCa e28:PGRP-LCa:LPS e29:Hsp70:LPS e3: e30:Hsp90:LPS e31:CXCR4:LPS e32:GDF5:LPS e33:CR3(CD11b) e34:CR3(CD11b):LPS e35:NF-kappaB{active} e36:CD55 e37:CD55:LPS e38:L-selectin:LPS e39:P-selectin:LPS e4: e40:SP-A e41:LPS:SP-A e42:SP-D e43:LPS:SP-D e44:SP-C e45:SP-C:LPS e46:SP-C:mCD14 e47:SP-C:MCD14:LPS e48:phospholipids e49:SP-A:phospholipids e5:Hageman factor e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS:Hageman factor{active} e60: e61: e62: e63:phospholipids:SP-D e64:cecropin e65:LPS:cecropin e66:sarcotoxin IA e67:LPS:sarcotoxin IA e68:melittin e69:LPS:melittin e7:mCD14 e70:Attacin e71:LPS:Attacin e72:MBP e73:LPS:MBP e74:C1q e75:C1q:LPS e76:C3 e77:LPS:C3 e78:HDLs e79:LPS:HDLs e8: e80:LDLs e81:LDLs:LPS e82:VLDLs e83:VLDLs:LPS e84:chylomicrons e85:LPS:chylomicrons e86:apoE e87:LPS:apoE e88:SAP e89:LPS:SAP e9: e90:SAP:heparin e91:3-sulfated carbohydrates e92:SAP:3-sulfated carbohydrates e93:M6P e94:SAP:M6P e95:Hb:LPS e96:LPS:BPI e97:Heparin:BPI e98:Lactoferrin e99:Iron

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98
Model Detail
483.0, 983.0
25.0, 25.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
682.0, 1034.0
28.0, 28.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
363.0, 1255.0
26.0, 26.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p56

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
228.0, 760.0
23.5, 23.5

GDF5

--

MO000005766

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m689

10

false

infinite

0

unit false false false
InterProIPR002400
TRANSPATHMO000005766

--

Go back
225.0, 1061.0
30.0, 30.0

SELPLG(P-selectin)

--

MO000012555

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m1347

10

false

infinite

0

unit false false false
TRANSPATHMO000012555

--

Go back
228.0, 432.0
24.0, 24.0

RP105

--

MO000016653

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m1632

10

false

infinite

0

unit false false false
InterProIPR000483
TRANSPATHMO000016653

--

Go back
408.0, 120.0
23.0, 23.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p4 p5 p9 p11 p13 p14 p15 p16 p17 p18 p19 p21 p22 p23 p24 p25 p26 p28 p31 p32 p33 p34 p35 p36 p37 p38 p39 p40 p41 p42 p43 p47 p48 p55 p59 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p70 p71 p72 p85 p86 p87 p88 p89 p90 p91 p92 p93 p94 p95 p98

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
661.0, 397.0
29.0, 29.0

tubulin

--

MO000017075

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p77

true true true true

csml-variable:Double

m1967

10

false

infinite

0

unit false false false
TRANSPATHMO000017075

--

Go back
220.0, 636.0
32.0, 32.0

CXCR4

--

MO000017157

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m2033

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000017157

--

Go back
183.0, 95.0
25.0, 25.0

sCD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6 p7

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
696.0, 44.0
23.0, 23.0

apo A1

--

MO000018240

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

p2 p96 p97

true true true true

csml-variable:Double

m2916

10

false

infinite

0

unit false false false
InterProIPR000712
TRANSPATHMO000018240

--

Go back
1166.0, 566.0
28.0, 28.0

heparin

--

MO000018926

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44 p49 p51

true true true true

csml-variable:Double

m356124

10

false

infinite

0

unit false false false
TRANSPATHMO000018926

--

Go back
226.0, 278.0
27.0, 27.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
660.0, 12.0
24.0, 24.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
819.0, 863.0
33.0, 33.0

Hsp90

--

MO000021135

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m5516

10

false

infinite

0

unit false false false
TRANSPATHMO000021135

--

Go back
825.0, 733.0
30.0, 30.0

Hsp70

--

MO000021614

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m5956

10

false

infinite

0

unit false false false
InterProIPR001023
TRANSPATHMO000021614

--

Go back
119.0, 283.0
26.0, 26.0

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p9

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
153.0, 397.0
30.0, 30.0

MD-1

--

MO000022200

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m6500

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022200

--

Go back
404.0, 516.0
32.0, 32.0

moesin

--

MO000023102

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76

true true true true

csml-variable:Double

m6914

10

false

infinite

0

unit false false false
InterProIPR008954
TRANSPATHMO000023102

--

Go back
924.0, 892.0
24.0, 24.0

BPI

--

MO000061423

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48 p49

true true true true

csml-variable:Double

m36321

10

false

infinite

0

unit false false false
TRANSPATHMO000061423

--

Go back
242.0, 1238.0
27.0, 27.0

SLPI

--

MO000064893

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65

true true true true

csml-variable:Double

m39762

10

false

infinite

0

unit false false false
TRANSPATHMO000064893

--

Go back
761.0, 41.0
22.0, 22.0

PLTP

--

MO000066851

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p96

true true true true

csml-variable:Double

m41708

10

false

infinite

0

unit false false false
TRANSPATHMO000066851

--

Go back
548.0, 16.0
24.0, 24.0

CETP

--

MO000069324

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p97

true true true true

csml-variable:Double

m44168

10

false

infinite

0

unit false false false
TRANSPATHMO000069324

--

Go back
1004.0, 1268.0
24.0, 24.0

hCAP18(h)

--

MO000079001

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p71

true true true true

csml-variable:Double

m286360

10

false

infinite

0

unit false false false
Affymetrix210244_at
EnsemblENSG00000164047
HGNCCAMP
OMIM600474
ProteomeHumanPSD/CAMP
RefSeqNM_004345
TRANSPATHMO000079001
UnigeneHs.112760
UniProtP49913

--

Go back
777.0, 1129.0
29.0, 29.0

L-selectin

--

MO000089774

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m63356

10

false

infinite

0

unit false false false
TRANSPATHMO000089774

--

Go back
985.0, 17.0
30.0, 30.0

hemoglobin

--

MO000100669

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m73673

10

false

infinite

0

unit false false false
TRANSPATHMO000100669

--

Go back
215.20120784347085, 223.8712597825493
650.1484172764835, 944.0155018854513

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
217.2239362215278, 255.70043308042509
629.1200205905815, 884.9949701285165

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1061.5, 1086.0
29.811531411431428, 36.50391601399767

Lactoferrin:Iron

--

e100

cso30:c:Complex

cso30:i:CC_Extracellular

--

p50

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
1217.5, 987.0
28.072321279786703, 34.37427095484086

Lactoferrin:Heparin

--

e101

cso30:c:Complex

cso30:i:CC_Extracellular

--

p51

--

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
960.0, 1161.0
16.514499532273156, 38.110383536014965

proteoglycans

--

e102

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p52

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
941.5, 1007.0
28.562239626728875, 34.974170971504755

Lactoferrin:proteoglycans

--

e103

cso30:c:Complex

cso30:i:CC_Extracellular

--

p52

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1102.0, 1217.5
60.0, 13.0

DNA

--

e104

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p53

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
1174.0, 1127.5
60.0, 17.0

Lactoferrin:DNA

--

e105

cso30:c:Complex

cso30:i:CC_Extracellular

--

p53

--

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
1176.0, 759.0
47.46005046257359, 26.894028595458366

oligonucleotide

--

e106

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p54

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
1250.5, 856.0
26.390268288618564, 32.31461423096151

lactoferrin:oligo

--

e107

cso30:c:Complex

cso30:i:CC_Extracellular

--

p54

--

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
1217.5, 683.0
28.11314780869855, 34.42426262289619

Lactoferrin:LPS

--

e108

cso30:c:Complex

cso30:i:CC_Extracellular

--

p55

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
759.0, 1261.5
34.46166230629905, 21.25135842221775

HBP

--

e109

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p57 p58 p59

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
786.5, 148.0
26.61073154474254, 32.584569238460254

LBP:apoA1

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
831.5, 1184.0
25.933011164805862, 31.754707548741877

HBP:syndecans

--

e110

cso30:c:Complex

cso30:i:CC_Extracellular

--

p57

--

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
911.0, 1184.0
17.000935453695043, 39.23292797006548

syndecans

--

e111

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p57

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
649.0, 1297.0
13.32834424695977, 30.757717492984106

glypicans

--

e112

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p58

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
684.5, 1214.0
23.5324112647892, 28.81519746708882

HBP:glypicans

--

e113

cso30:c:Complex

cso30:i:CC_Extracellular

--

p58

--

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
447.5, 1269.0
24.52041326445593, 30.024995834027667

LPS:HBP

--

e114

cso30:c:Complex

cso30:i:CC_Extracellular

--

p59

p56

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
56.0, 939.5
32.96, 24.72

Indolicidin

--

e115

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p60

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
108.5, 1001.0
26.365772371271454, 32.284619230128314

Indolicidin:LPS

--

e116

cso30:c:Complex

cso30:i:CC_Extracellular

--

p60

--

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
41.0, 1076.5
29.759999999999998, 22.319999999999997

Bac5

--

e117

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p61

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
117.5, 1154.0
29.452257957007166, 36.06398933511082

Bac5:LPS

--

e118

cso30:c:Complex

cso30:i:CC_Extracellular

--

p61

--

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
88.0, 1235.5
32.160000000000004, 24.12

Prophenin

--

e119

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p62

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
534.5, 232.0
26.33311114814197, 32.24462589568405

LBP:mCD14

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3 p74

p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
178.5, 1296.0
26.643392767872022, 32.62456257290452

Prophenin:LPS

--

e120

cso30:c:Complex

cso30:i:CC_Extracellular

--

p62

--

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
95.0, 393.5
34.32883880056349, 21.16945059368082

C1 inhibitor

--

e121

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p63

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
134.5, 531.0
27.067988668555248, 33.14447592067989

LPS:C1 inhibitor

--

e122

cso30:c:Complex

cso30:i:CC_Extracellular

--

p63

--

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false false false

--

Go back
57.5, 771.0
20.417387804387197, 33.109277520627884

Lysozyme

--

e123

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p64

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
78.5, 872.0
26.161639726712213, 32.03466088985169

Lysozyme:LPS

--

e124

cso30:c:Complex

cso30:i:CC_Extracellular

--

p64

--

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false false false

--

Go back
292.5, 1286.0
22.985335777370423, 28.14530911514748

LPS:SLPI

--

e125

cso30:c:Complex

cso30:i:CC_Extracellular

--

p65

--

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
67.0, 614.0
50.08410428931876, 28.380992430613958

Dermatan

--

e126

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p66

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
79.5, 425.0
24.70821529745042, 30.25495750708215

Dermatan:LPS

--

e127

cso30:c:Complex

cso30:i:CC_Extracellular

--

p66

--

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
57.0, 339.0
46.65264928511354, 26.436501261564338

Heparan

--

e128

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p67

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
85.5, 494.8093651058157
21.5972337943676, 26.445592401266456

Dermatan:LPS

--

e129

cso30:c:Complex

cso30:i:CC_Extracellular

--

p67

--

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false false false

--

Go back
333.5, 228.0
28.36942558267572, 39.585244999082406

LBP:mCD14:LPS

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p73

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
14.0, 124.0
43.82674516400337, 24.83515559293524

Dextran sulfate

--

e130

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p68

true true true true

csml-variable:Double

m131

0

false

infinite

0

unit false false false

--

Go back
63.0, 254.0
25.40883977900551, 28.23204419889503

LPS:Dextran sulfate

--

e131

cso30:c:Complex

cso30:i:CC_Extracellular

--

p68

--

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
1047.0, 212.5
34.93848857644991, 22.710017574692444

Histatin

--

e132

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p69

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false false false

--

Go back
1070.5, 264.0
26.749541743042826, 32.75454090984835

LPS:Histatin

--

e133

cso30:c:Complex

cso30:i:CC_Extracellular

--

p69

--

true true true true

csml-variable:Double

m134

0

false

infinite

0

unit false false false

--

Go back
1184.0, 307.0
15.15247895229186, 34.96725912067352

HNP-1

--

e134

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p70

true true true true

csml-variable:Double

m135

0

false

infinite

0

unit false false false

--

Go back
1114.5, 432.0
26.398433594400935, 32.32461256457257

LPS:HNP-1

--

e135

cso30:c:Complex

cso30:i:CC_Extracellular

--

p70

--

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false false false

--

Go back
989.0, 1324.5
29.6, 22.199999999999996

SMAP-29

--

e136

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p72

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false false false

--

Go back
779.5, 1349.0
24.112147975337443, 29.525079153474422

SMAP-29:LPS

--

e137

cso30:c:Complex

cso30:i:CC_Extracellular

--

p72

--

true true true true

csml-variable:Double

m138

0

false

infinite

0

unit false false false

--

Go back
1050.5, 1159.0
27.566072321279787, 33.75437427095484

LPS:hCAP18

--

e138

cso30:c:Complex

cso30:i:CC_Extracellular

--

p71

--

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
223.0, 378.0
26.47058823529412, 44.11764705882353

MD-2:TLR4:LBP:mCD14:LPS

--

e139

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p73

p74

true true true true

csml-variable:Double

m140

0

false

infinite

0

unit false false false

--

Go back
642.5, 120.0
26.16163972671223, 32.03466088985169

LPS:sCD14

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
512.0, 396.0
23.0, 23.0

LPS

--

e140

cso30:c:Protein

cso30:i:CC_CellComponent

--

p74

p75 p76 p77 p78 p79 p80 p81 p82 p83 p84

true true true true

csml-variable:Double

m141

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
831.0, 315.0
17.949485500467723, 41.42188961646398

P2X7

--

e141

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p75

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false false false

--

Go back
609.5, 534.0
29.640059990001664, 36.2939510081653

LPS:P2X7

--

e142

cso30:c:Complex

cso30:i:CC_Cytosol

--

p75

--

true true true true

csml-variable:Double

m143

0

false

infinite

0

unit false false false

--

Go back
491.5, 549.0
25.05115814030996, 30.67488751874687

LPS:moesin

--

e143

cso30:c:Complex

cso30:i:CC_Cytosol

--

p76

--

true true true true

csml-variable:Double

m144

0

false

infinite

0

unit false false false

--

Go back
648.5, 502.0
30.129978336943843, 36.8938510248292

LPS:Tubulin

--

e144

cso30:c:Complex

cso30:i:CC_Cytosol

--

p77

--

true true true true

csml-variable:Double

m145

0

false

infinite

0

unit false false false

--

Go back
536.0, 599.5
32.8, 24.600000000000005

proteasome

--

e145

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p78

true true true true

csml-variable:Double

m146

0

false

infinite

0

unit false false false

--

Go back
827.5, 420.0
25.93301116480587, 31.75470754874187

LPS:proteasome

--

e146

cso30:c:Complex

cso30:i:CC_Cytosol

--

p78

--

true true true true

csml-variable:Double

m147

0

false

infinite

0

unit false false false

--

Go back
315.5, 434.0
16.72408935399477, 27.120144898369887

H1

--

e147

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p79

true true true true

csml-variable:Double

m148

0

false

infinite

0

unit false false false

--

Go back
362.5, 535.0
27.949841693051162, 34.22429595067489

LPS:H1

--

e148

cso30:c:Complex

cso30:i:CC_Cytosol

--

p79

--

true true true true

csml-variable:Double

m149

0

false

infinite

0

unit false false false

--

Go back
402.5, 325.0
18.533507748037835, 30.05433688871

H2A

--

e149

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p56 p80 p84

true true true true

csml-variable:Double

m150

0

false

infinite

0

unit false false false

--

Go back
811.9428090832632, 38.10092514718252
48.21698906644239, 27.32296047098402

LTA

--

e15

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
433.5, 286.0
29.81153141143143, 36.50391601399767

H2A:LPS

--

e150

cso30:c:Complex

cso30:i:CC_Cytosol

--

p80

--

true true true true

csml-variable:Double

m151

0

false

infinite

0

unit false false false

--

Go back
681.5, 343.0
20.826926947071843, 33.7733950493057

H2B

--

e151

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p81

true true true true

csml-variable:Double

m152

0

false

infinite

0

unit false false false

--

Go back
595.5, 237.0
24.879686718880187, 30.46492251291452

H2B:LPS

--

e152

cso30:c:Complex

cso30:i:CC_Cytosol

--

p81

--

true true true true

csml-variable:Double

m153

0

false

infinite

0

unit false false false

--

Go back
366.5, 645.0
19.11430871402697, 30.996176293016706

H3

--

e153

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p82

true true true true

csml-variable:Double

m154

0

false

infinite

0

unit false false false

--

Go back
482.5, 644.0
26.382102982836205, 32.30461589735045

H3:LPS

--

e154

cso30:c:Complex

cso30:i:CC_Cytosol

--

p82

--

true true true true

csml-variable:Double

m155

0

false

infinite

0

unit false false false

--

Go back
710.5, 632.0
19.978063996780033, 32.396860535318964

H4

--

e155

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p83

true true true true

csml-variable:Double

m156

0

false

infinite

0

unit false false false

--

Go back
674.5, 708.0
26.24329278453592, 32.13464422596234

LPS:H4

--

e156

cso30:c:Complex

cso30:i:CC_Cytosol

--

p83

--

true true true true

csml-variable:Double

m157

0

false

infinite

0

unit false false false

--

Go back
462.0, 863.0
44.407064760302774, 25.164003364171574

NO

--

e157

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p84

--

true true true true

csml-variable:Double

m158

0

false

infinite

0

unit false false false

--

Go back
1209.0, 387.0
14.422825070159027, 33.283442469597745

HNP-2

--

e158

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p85

true true true true

csml-variable:Double

m159

0

false

infinite

0

unit false false false

--

Go back
1202.5, 528.0
26.398433594400935, 32.32461256457257

LPS:HNP-2

--

e159

cso30:c:Complex

cso30:i:CC_Extracellular

--

p85

--

true true true true

csml-variable:Double

m160

0

false

infinite

0

unit false false false

--

Go back
525.0, 47.0
45.037846930193446, 25.521446593776282

Phosphatidyl inositol

--

e16

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1132.0, 170.0
15.711880261927035, 36.25818521983162

HNP-3

--

e160

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p86

true true true true

csml-variable:Double

m161

0

false

infinite

0

unit false false false

--

Go back
1130.5, 316.0
26.398433594400935, 32.32461256457257

LPS:HNP-3

--

e161

cso30:c:Complex

cso30:i:CC_Extracellular

--

p86

--

true true true true

csml-variable:Double

m162

0

false

infinite

0

unit false false false

--

Go back
1104.0, 114.0
15.56594948550047, 35.92142188961647

HNP-4

--

e162

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p87

true true true true

csml-variable:Double

m163

0

false

infinite

0

unit false false false

--

Go back
1054.5, 56.0
26.398433594400935, 32.32461256457257

LPS:HNP-4

--

e163

cso30:c:Complex

cso30:i:CC_Extracellular

--

p87

--

true true true true

csml-variable:Double

m164

0

false

infinite

0

unit false false false

--

Go back
1201.0, 82.5
29.912126537785582, 19.442882249560625

PMB

--

e164

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p88

true true true true

csml-variable:Double

m165

0

false

infinite

0

unit false false false

--

Go back
333.5, 14.878020329945002
20.952174637560407, 25.655724045992336

LPS:PMB

--

e165

cso30:c:Complex

cso30:i:CC_Extracellular

--

p88

--

true true true true

csml-variable:Double

m166

0

false

infinite

0

unit false false false

--

Go back
1226.0, 146.5
27.978910369068537, 18.186291739894557

gramicidine

--

e166

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p89

true true true true

csml-variable:Double

m167

0

false

infinite

0

unit false false false

--

Go back
416.5, 54.0
22.356607232127978, 27.37543742709549

gramicidine:LPS

--

e167

cso30:c:Complex

cso30:i:CC_Extracellular

--

p89

--

true true true true

csml-variable:Double

m168

0

false

infinite

0

unit false false false

--

Go back
593.5, 1338.0
16.75387401891729, 27.168444355001007

Lectins

--

e168

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p90

true true true true

csml-variable:Double

m169

0

false

infinite

0

unit false false false

--

Go back
544.5, 1390.0
22.60156640559907, 27.67538743542743

LPS:lectin

--

e169

cso30:c:Complex

cso30:i:CC_Extracellular

--

p90

--

true true true true

csml-variable:Double

m170

0

false

infinite

0

unit false false false

--

Go back
892.5, 14.0
22.078986835527417, 27.035494084319282

sCD14:LTA

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
323.0, 72.0
10.25163704396632, 23.657623947614585

FhuA

--

e170

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p91

true true true true

csml-variable:Double

m171

0

false

infinite

0

unit false false false

--

Go back
330.0, 127.0
11.613657623947613, 26.80074836295603

ompT

--

e171

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p92

true true true true

csml-variable:Double

m172

0

false

infinite

0

unit false false false

--

Go back
322.0, 175.0
11.601496725912071, 26.772684752104777

MsbA

--

e172

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p93

true true true true

csml-variable:Double

m173

0

false

infinite

0

unit false false false

--

Go back
382.5, 68.0
19.22112981169805, 23.536077320446598

LPS:FhuA

--

e173

cso30:c:Complex

cso30:i:CC_Cytosol

--

p91

--

true true true true

csml-variable:Double

m174

0

false

infinite

0

unit false false false

--

Go back
366.5, 104.0
19.22112981169805, 23.536077320446598

LPS:ompT

--

e174

cso30:c:Complex

cso30:i:CC_Cytosol

--

p92

--

true true true true

csml-variable:Double

m175

0

false

infinite

0

unit false false false

--

Go back
366.5, 160.0
19.22112981169805, 23.536077320446598

LPS:MsbA

--

e175

cso30:c:Complex

cso30:i:CC_Cytosol

--

p93

--

true true true true

csml-variable:Double

m176

0

false

infinite

0

unit false false false

--

Go back
251.0, 1378.5
25.92, 19.439999999999998

Lysosomal phosphatases

--

e176

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p94

true true true true

csml-variable:Double

m177

0

false

infinite

0

unit false false false

--

Go back
308.5, 1433.0
23.92434594234294, 29.29511748041993

Lysosomal phosphatases:LPS

--

e177

cso30:c:Complex

cso30:i:CC_Extracellular

--

p94

--

true true true true

csml-variable:Double

m178

0

false

infinite

0

unit false false false

--

Go back
394.0, 1329.5
27.519999999999985, 20.639999999999997

Granule acyloxyacyl hydrolase

--

e178

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p95

true true true true

csml-variable:Double

m179

0

false

infinite

0

unit false false false

--

Go back
500.5, 1477.0
23.92434594234294, 29.29511748041993

Granule acyloxyacyl hydrolase:LPS

--

e179

cso30:c:Complex

cso30:i:CC_Extracellular

--

p95

--

true true true true

csml-variable:Double

m180

0

false

infinite

0

unit false false false

--

Go back
46.5, 16.0
26.61889685052491, 32.59456757207131

sCD14:phosphatidyl inositol

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
724.5, 178.0
22.144309281786363, 27.11548075320779

PLTP:apoA1

--

e180

cso30:c:Complex

cso30:i:CC_Extracellular

--

p96

p98

true true true true

csml-variable:Double

m181

0

false

infinite

0

unit false false false

--

Go back
594.5, 80.0
20.004999166805526, 24.495917347108815

LPS:CETP

--

e181

cso30:c:Complex

cso30:i:CC_Cytosol

--

p97

--

true true true true

csml-variable:Double

m182

0

false

infinite

0

unit false false false

--

Go back
853.5, 199.0
21.90751541409765, 26.825529078486916

PLTP:apoA1:LPS

--

e182

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p98

--

true true true true

csml-variable:Double

m183

0

false

infinite

0

unit false false false

--

Go back
221.5, 327.0
28.309115147475417, 34.66422262956174

MD-2:TLR4

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8 p74

p73

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
215.20120784347085, 223.8712597825493
650.1484172764835, 944.0155018854513

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
167.5, 260.0
25.998333611064822, 31.8346942176304

LPS:MD-2

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
224.5, 493.0
31.477253791034833, 38.54357607065489

MD-1:RP105

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p11

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
228.5, 557.0
23.659504494628372, 45.792589344442014

MD-1:RP105:LPS

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
826.5, 372.0
26.228471001757473, 40.35149384885765

PGRP-LCx

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12 p13

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1001.0, 163.0
46.829268292682926, 26.536585365853657

peptidoglycan

--

e24

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
828.5, 475.0
22.11664108748082, 42.80640210480159

PGRP-LCx:peptidoglycan

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
828.5, 263.0
22.11664108748082, 42.80640210480159

PGRP-LCx:LPS

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
826.5, 539.0
27.48506151142355, 42.28471001757469

PGRP-LCa

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p14

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
828.5, 609.0
23.652707739530804, 45.77943433457575

PGRP-LCa:LPS

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
824.5, 789.0
23.577943433457573, 45.63472922604693

Hsp70:LPS

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
228.2041761890004, 236.87422812807887
624.1424805854243, 918.0095651943913

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
828.5, 937.0
23.632317474238107, 45.73996930497698

Hsp90:LPS

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
223.5, 691.0
25.406270554702914, 49.17342688007017

CXCR4:LPS

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
226.5, 822.0
26.45976759482569, 51.212453409340064

GDF5:LPS

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
826.5, 1023.0
27.256590509666083, 41.933216168717045

CR3(CD11b)

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p19

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
823.5, 1088.0
24.611050208287658, 47.634290725718046

CR3(CD11b):LPS

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p20

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
650.0, 910.0
28.0, 28.0

NF-kappaB{active}

--

e35

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

--

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
224.5, 893.0
30.158172231985937, 46.397188049209134

CD55

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p21

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
226.5, 969.0
27.737557553168166, 53.68559526419645

CD55:LPS

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
708.5, 1122.0
22.3817145362859, 43.31944748958563

L-selectin:LPS

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
231.5, 1111.0
25.7529050646788, 49.8443323832493

P-selectin:LPS

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
252.25966762823063, 259.6294227327554
576.0314977069646, 872.4991759850376

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1008.0, 325.0
16.344246959775493, 37.71749298409729

SP-A

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23 p29

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
994.5, 400.0
26.406598900183308, 32.33461089818365

LPS:SP-A

--

e41

cso30:c:Complex

cso30:i:CC_Extracellular

--

p23

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1051.0, 482.0
18.80074836295604, 43.38634237605239

SP-D

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p25 p30

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
827.5, 673.0
24.47958673554408, 29.975004165972347

LPS:SP-D

--

e43

cso30:c:Complex

cso30:i:CC_Extracellular

--

p25

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
139.0, 575.0
18.460243217960716, 42.60056127221703

SP-C

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p26 p27

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
65.5, 658.0
29.15014164305948, 35.69405099150142

SP-C:LPS

--

e45

cso30:c:Complex

cso30:i:CC_Extracellular

--

p26

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
273.5, 231.0
28.227462089651727, 34.5642392934511

SP-C:mCD14

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

p28

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
219.5, 210.0
32.15727656450724, 44.870618462103145

SP-C:MCD14:LPS

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
709.0, 235.0
45.34062237174096, 25.693019343986542

phospholipids

--

e48

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p29 p30

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
782.5, 232.0
26.28411931344775, 32.18463589401767

SP-A:phospholipids

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
241.0, 30.5
30.959951700543375, 19.091970215335085

Hageman factor

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
427.03930375170523, 905.7111094388533
217.26094608420928, 197.0318077151023

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
450.50510425986926, 910.3804768425075
127.03898895799212, 190.96306620437014

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
429.8713831233802, 908.3408974268372
211.59678734085952, 191.77223173913433

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
430.27596589076234, 908.7454801942196
210.7876218060951, 190.96306620437014

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
427.03930375170523, 905.7111094388533
217.26094608420928, 197.0318077151023

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
427.03930375170523, 905.7111094388533
217.26094608420928, 197.0318077151023

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
430.27596589076234, 908.7454801942196
210.7876218060951, 190.96306620437014

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
585.635748565504, 986.6276629152815
13.57327017018805, 12.28738141722286

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
550.032465035876, 1043.2692503487808
38.43536290130336, 34.79411799486408

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
427.03930375170523, 905.7111094388533
217.26094608420928, 197.0318077151023

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
163.5, 49.0
24.11214797533744, 29.52507915347443

LPS:Hageman factor{active}

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
478.24648630055214, 993.2704167002146
6.880334931059949, 3.3127538556955245

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
478.0167324418548, 983.3910007762241
23.549770516488746, 42.389586929679645

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
487.89614836584525, 1010.9614638199185
3.6760617391592123, 3.6760617391592056

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
445.5, 231.0
28.162139643392756, 34.48425262456258

phospholipids:SP-D

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
873.0, 80.5
29.439999999999976, 22.079999999999995

cecropin

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
831.5, 129.0
25.034827528745197, 30.654890851524744

LPS:cecropin

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1045.0, 540.5
30.720000000000006, 23.04

sarcotoxin IA

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p32

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
998.5, 644.0
26.863856023996, 32.894517580403274

LPS:sarcotoxin IA

--

e67

cso30:c:Complex

cso30:i:CC_Extracellular

--

p32

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
52.0, 719.5
32.15999999999999, 24.120000000000005

melittin

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
125.5, 851.0
28.382602899516748, 34.75420763206132

LPS:melittin

--

e69

cso30:c:Complex

cso30:i:CC_Extracellular

--

p33

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
651.0, 239.0
25.0, 25.0

mCD14

--

e7

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p27

true true true true

csml-variable:Double

m7

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
1026.0, 809.5
28.32000000000001, 21.239999999999995

Attacin

--

e70

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p34

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
962.5, 796.0
26.202466255624064, 32.08465255790702

LPS:Attacin

--

e71

cso30:c:Complex

cso30:i:CC_Extracellular

--

p34

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
981.5, 123.0
20.774803783457443, 33.688871000201246

MBP

--

e72

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p35

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
922.0, 168.0
28.591160220994475, 31.76795580110497

LPS:MBP

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
107.0, 72.5
34.79789103690686, 22.618629173989454

C1q

--

e74

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p36

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
39.0, 89.0
26.850828729281766, 29.834254143646415

C1q:LPS

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
90.0, 127.5
28.93137452203662, 17.841014288589253

C3

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p37

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
70.5, 299.0
27.843692717880344, 34.094317613731036

LPS:C3

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
292.0, 1183.0
15.115996258185215, 34.883068288119716

HDLs

--

e78

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p38

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
356.5, 1186.0
22.60973171138143, 27.68538576903849

LPS:HDLs

--

e79

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p38

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
220.86618341557775, 228.38216210651214
642.4965255924988, 932.9049551603077

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
424.0, 1183.0
15.115996258185216, 34.883068288119745

LDLs

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p39

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
505.5, 1183.0
28.17847025495751, 34.50424929178472

LDLs:LPS

--

e81

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p39

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
572.0, 1186.0
15.906454630495784, 36.707202993451816

VLDLs

--

e82

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p40

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
624.5, 1234.0
23.246625562406273, 28.465255790701562

VLDLs:LPS

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
705.0, 1183.0
14.422825070159027, 33.283442469597745

chylomicrons

--

e84

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p41

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
776.5, 1206.0
23.360939843359443, 28.605232461256463

LPS:chylomicrons

--

e85

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p41

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
982.0, 237.5
28.799999999999997, 21.60000000000001

apoE

--

e86

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p42

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
950.5, 288.0
26.15347442092984, 32.02466255624062

LPS:apoE

--

e87

cso30:c:Complex

cso30:i:CC_Extracellular

--

p42

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
955.0, 453.5
33.04042179261863, 21.476274165202113

SAP

--

e88

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p43 p44 p45 p46

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
966.5, 575.0
27.990668221963006, 34.27428761873021

LPS:SAP

--

e89

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
228.5781985896753, 227.33932058780766
634.6705886858496, 913.6271152996137

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1126.5, 612.0
26.42292951174805, 32.354607565405765

SAP:heparin

--

e90

cso30:c:Complex

cso30:i:CC_Extracellular

--

p44

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
1134.0, 703.0
44.96215306980656, 25.478553406223718

3-sulfated carbohydrates

--

e91

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p45

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
1081.0, 775.0
30.679558011049725, 34.08839779005526

SAP:3-sulfated carbohydrates

--

e92

cso30:c:Complex

cso30:i:CC_Extracellular

--

p45

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1037.0, 379.0
45.542472666105965, 25.807401177460047

M6P

--

e93

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p46

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
1090.0, 340.0
28.9889502762431, 32.209944751381215

SAP:M6P

--

e94

cso30:c:Complex

cso30:i:CC_Extracellular

--

p46

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1095.5, 193.0
24.593901016497252, 30.11498083652724

Hb:LPS

--

e95

cso30:c:Complex

cso30:i:CC_Extracellular

--

p47

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
953.5, 955.0
28.015164139310105, 34.30428261956341

LPS:BPI

--

e96

cso30:c:Complex

cso30:i:CC_Extracellular

--

p48

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
1041.5, 919.0
28.03149475087485, 34.32427928678553

Heparin:BPI

--

e97

cso30:c:Complex

cso30:i:CC_Extracellular

--

p49

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1133.5, 1028.0
20.208895149929567, 32.77118132421011

Lactoferrin

--

e98

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p50 p51 p52 p53 p54 p55

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
937.5, 1089.0
36.61982770795083, 37.24050275384832

Iron

--

e99

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p50

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
244.0, 96.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155666*m5*0.1

nodelay

--

true

0

false

PMID: 15241548,4378413 The observation that the lipid A region of LPS interacts directly with plasma factor XII (Hageman factor) suggests that this factor contains an LPS binding site. PMID: 15241548 This interaction with LPS activates factor XII, and triggers the intrinsic coagulation pathway.

Go back
140.0, 484.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022200 MO000016653

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m6500*m1632*0.1

nodelay

--

true

0

false

PMID: 15241548,11521060 Concerning B lymphocytes, in addition to TLR4-MD-2, another cell surface complex, RP105-MD-1, is also involved in the recognition of LPS

Go back
320.0, 488.0
23.0, 23.0

p10

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m155666*m21*0.1

nodelay

--

true

0

false

PMID: 15241548,11521060 Concerning B lymphocytes, in addition to TLR4-MD-2, another cell surface complex, RP105-MD-1, is also involved in the recognition of LPS

Go back
1026.0, 278.0
20.0, 20.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 e23

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m24*m23*0.1

nodelay

--

true

0

false

PMID: 15241548 This LPS-binding capacity could be due to PGRP-LCa, because PGRP-LCx is required for activation by both peptidoglycan and LPS, whereas PGRP-LCa is required only for activation by LPS.

Go back
941.0, 57.0
22.0, 22.0

p12

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e23

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m155666*m23*0.1

nodelay

--

true

0

false

PMID: 15241548 This LPS-binding capacity could be due to PGRP-LCa, because PGRP-LCx is required for activation by both peptidoglycan and LPS, whereas PGRP-LCa is required only for activation by LPS.

Go back
761.0, 353.0
22.0, 22.0

p12

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m155666*m27*0.1

nodelay

--

true

0

false

PMID: 15241548 This LPS-binding capacity could be due to PGRP-LCa, because PGRP-LCx is required for activation by both peptidoglycan and LPS, whereas PGRP-LCa is required only for activation by LPS.

Go back
752.0, 536.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000021614

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m155666*m5956*0.1

nodelay

--

true

0

false

PMID: 15241548,11276205 Triantafilou et al. identified heat shock proteins 70 and 90 (HSP70 and HSP90), chemokine receptor 4 (CXCR4) and growth differentiation factor 5 (GDF-5) as four new molecules on the cell surface that bind LPS and are involved in LPS-induced signaling

Go back
724.0, 608.0
23.0, 23.0

p15

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000021135

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m155666*m5516*0.1

nodelay

--

true

0

false

PMID: 15241548,11276205 Triantafilou et al. identified heat shock proteins 70 and 90 (HSP70 and HSP90), chemokine receptor 4 (CXCR4) and growth differentiation factor 5 (GDF-5) as four new molecules on the cell surface that bind LPS and are involved in LPS-induced signaling

Go back
276.0, 632.0
23.0, 23.0

p15

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000017157

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m155666*m2033*0.1

nodelay

--

true

0

false

PMID: 15241548,11276205 Triantafilou et al. identified heat shock proteins 70 and 90 (HSP70 and HSP90), chemokine receptor 4 (CXCR4) and growth differentiation factor 5 (GDF-5) as four new molecules on the cell surface that bind LPS and are involved in LPS-induced signaling

Go back
308.0, 752.0
23.0, 23.0

p15

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000005766

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m155666*m689*0.1

nodelay

--

true

0

false

PMID: 15241548,11276205 Triantafilou et al. identified heat shock proteins 70 and 90 (HSP70 and HSP90), chemokine receptor 4 (CXCR4) and growth differentiation factor 5 (GDF-5) as four new molecules on the cell surface that bind LPS and are involved in LPS-induced signaling

Go back
728.0, 764.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m155666*m34*0.1

nodelay

--

true

0

false

PMID: 15241548,2462607 A specific LPS binding motif was also shown in the CD11b chain of one of the three adhesion molecules (CR3) belonging to the b-integrin family

Go back
624.0, 56.0
23.0, 23.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019420 MO000018240

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3985*m2916*0.1

nodelay

--

true

0

false

PMID: 15241548 Another plasma protein in association with apo A1 is lipopolysaccharide-binding protein (LBP)

Go back
740.0, 960.0
23.0, 23.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e34 MO000000058

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m35*m33*0.1

nodelay

--

true

0

false

PMID: 15241548,9200483 CR3 can mediate LPS-induced activation of NF-kB in transfected CHO cells, although its cytosolic domain is not required for signaling

Go back
352.0, 892.0
24.0, 24.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m155666*m37*0.1

nodelay

--

true

0

false

PMID: 15241548 Another membrane molecule involved in LPS recognition and signaling is the decay accelerating factor (DAF, CD55).

Go back
713.0, 905.0
21.0, 21.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000089774

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m155666*m63356*0.1

nodelay

--

true

0

false

PMID: 15241548,8660298 For example, it has been reported that in human neutrophils, L-selectin (CD62L) can bind LPS

Go back
757.0, 321.0
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e40

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m155666*m41*0.1

nodelay

--

true

0

false

PMID;15241548 It has been established that the two hydrophilic surfactant proteins, SP-A and SP-D, bind phospholipids and LPS.

Go back
284.0, 1056.0
23.0, 23.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000012555

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m155666*m1347*0.1

nodelay

--

true

0

false

PMID: 15241548,9541593 In human platelets, LPS ligation occurs via another selectin, P-selectin

Go back
737.0, 393.0
21.0, 21.0

p23

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m155666*m43*0.1

nodelay

--

true

0

false

PMID;15241548 It has been established that the two hydrophilic surfactant proteins, SP-A and SP-D, bind phospholipids and LPS.

Go back
329.0, 585.0
21.0, 21.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e44 MO000016882

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m45*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548,11557581 In contrast, the authors reported that SP-C binds efficiently to LPS

Go back
332.0, 280.0
23.0, 23.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e44 e7

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m45*m7*0.1

nodelay

--

true

0

false

PMID: 15241548,12496149 We also demonstrated that CD14 shares with LPS the same binding region on SP-C, and that the interaction with SPC modifies the conformation of CD14, allowing it to bind LPS more efficiently

Go back
284.0, 324.0
23.0, 23.0

p27

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e46

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m155666*m47*0.1

nodelay

--

true

0

false

PMID: 15241548,12496149 We also demonstrated that CD14 shares with LPS the same binding region on SP-C, and that the interaction with SPC modifies the conformation of CD14, allowing it to bind LPS more efficiently

Go back
760.0, 288.0
23.0, 23.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 e40

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m49*m41*0.1

nodelay

--

true

0

false

PMID;15241548 It has been established that the two hydrophilic surfactant proteins, SP-A and SP-D, bind phospholipids and LPS.

Go back
676.0, 128.0
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 e7

e12 MO000018240

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m11*m7*0.1

nodelay

--

true

0

false

PMID: 15241548,12417309 A second function of LBP is to increase the interaction of LPS with soluble CD14 (sCD14) by forming a stable trimolecular complex PMID: 15241548,7510680 This requires an interaction between LBP and CD14 which is mediated by the C-terminal half of LBP PMID: 15241548,11500507 Unlike the membrane form, which requires LBP, sCD14 can directly bind LPS with a dissociation constant of 74 nM

Go back
724.0, 348.0
23.0, 23.0

p29

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 e48

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m43*m49*0.1

nodelay

--

true

0

false

PMID;15241548 It has been established that the two hydrophilic surfactant proteins, SP-A and SP-D, bind phospholipids and LPS.

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788.0, 80.0
23.0, 23.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m155666*m65*0.1

nodelay

--

true

0

false

PMID: 15241548,8569759,11330824,11820943,1536865,9720039 In insects, we can mention cecropin in Drosophila hemolymph, sarcotoxin IA from flesh fly, melittin in bee venom and attacin in silkmoth, which all bind LPS.

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1049.0, 625.0
22.0, 22.0

p31

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m155666*m67*0.1

nodelay

--

true

0

false

PMID: 15241548,8569759,11330824,11820943,1536865,9720039 In insects, we can mention cecropin in Drosophila hemolymph, sarcotoxin IA from flesh fly, melittin in bee venom and attacin in silkmoth, which all bind LPS.

Go back
113.0, 733.0
22.0, 22.0

p31

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m155666*m69*0.1

nodelay

--

true

0

false

PMID: 15241548,8569759,11330824,11820943,1536865,9720039 In insects, we can mention cecropin in Drosophila hemolymph, sarcotoxin IA from flesh fly, melittin in bee venom and attacin in silkmoth, which all bind LPS.

Go back
985.0, 701.0
22.0, 22.0

p31

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m155666*m71*0.1

nodelay

--

true

0

false

PMID: 15241548,8569759,11330824,11820943,1536865,9720039 In insects, we can mention cecropin in Drosophila hemolymph, sarcotoxin IA from flesh fly, melittin in bee venom and attacin in silkmoth, which all bind LPS.

Go back
906.5, 110.0
19.5, 19.5

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m155666*m73*0.1

nodelay

--

true

0

false

PMID:15241548,7540596 The polysaccharide portion of LPSs is recognized by components of the alternative pathway and, for some mannose-containing O-chains, by the mannan-binding protein of the lectin pathway

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244.0, 184.0
23.0, 23.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e74

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m155666*m75*0.1

nodelay

--

true

0

false

PMID: 15241548,351060,2649081,7372350,12390351 In addition, the lipid A portion of LPSs activates the classical pathway [66] via interaction with C1q and C3.

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104.0, 216.0
23.0, 23.0

p36

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e76 MO000016882

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m77*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548,351060,2649081,7372350,12390351 In addition, the lipid A portion of LPSs activates the classical pathway [66] via interaction with C1q and C3.

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433.0, 705.0
21.0, 21.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e78

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m155666*m79*0.1

nodelay

--

true

0

false

PMID: 15241548,7528733 LPS also binds to all of the major plasma lipoproteins: HDLs, low-density lipoproteins (LDLs), very low density lipoproteins (VLDLs) and chylomicrons

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464.0, 704.0
23.0, 23.0

p38

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e80

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m155666*m81*0.1

nodelay

--

true

0

false

PMID: 15241548,7528733 LPS also binds to all of the major plasma lipoproteins: HDLs, low-density lipoproteins (LDLs), very low density lipoproteins (VLDLs) and chylomicrons

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608.0, 140.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000016882

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m12*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548,11500507 Unlike the membrane form, which requires LBP, sCD14 can directly bind LPS with a dissociation constant of 74 nM PMID: 15241548,12417309 A second function of LBP is to increase the interaction of LPS with soluble CD14 (sCD14) by forming a stable trimolecular complex

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528.0, 708.0
23.0, 23.0

p38

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e82

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m155666*m83*0.1

nodelay

--

true

0

false

PMID: 15241548,7528733 LPS also binds to all of the major plasma lipoproteins: HDLs, low-density lipoproteins (LDLs), very low density lipoproteins (VLDLs) and chylomicrons

Go back
588.0, 708.0
23.0, 23.0

p38

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e84

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m155666*m85*0.1

nodelay

--

true

0

false

PMID: 15241548,7528733 LPS also binds to all of the major plasma lipoproteins: HDLs, low-density lipoproteins (LDLs), very low density lipoproteins (VLDLs) and chylomicrons

Go back
917.0, 229.0
21.0, 21.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m155666*m87*0.1

nodelay

--

true

0

false

PMID: 15241548,2463827,9153287 At least one type of protein constituent of lipoproteins, the apolipoprotein apoE, contains a heparin-binding sequence [and can directly bind LPS, possibly by its exposed hydrophilic domain involving arginine residues

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733.0, 421.0
21.0, 21.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e88

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m155666*m89*0.1

nodelay

--

true

0

false

PMID: 15241548,1547784 It (SAP) is a multispecific protein which binds heparin, various 3-sulfated carbohydrates, mannose- 6-phosphate and LPS

Go back
1149.0, 493.0
21.0, 21.0

p43

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e88 MO000018926

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m89*m356124*0.1

nodelay

--

true

0

false

PMID: 15241548,1547784 It (SAP) is a multispecific protein which binds heparin, various 3-sulfated carbohydrates, mannose- 6-phosphate and LPS

Go back
1085.0, 649.0
21.0, 21.0

p43

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e88 e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m89*m92*0.1

nodelay

--

true

0

false

PMID: 15241548,1547784 It (SAP) is a multispecific protein which binds heparin, various 3-sulfated carbohydrates, mannose- 6-phosphate and LPS

Go back
1045.0, 441.0
21.0, 21.0

p43

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e88 e93

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1

m89*m94*0.1

nodelay

--

true

0

false

PMID: 15241548,1547784 It (SAP) is a multispecific protein which binds heparin, various 3-sulfated carbohydrates, mannose- 6-phosphate and LPS

Go back
1013.0, 117.0
22.0, 22.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000100669

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m155666*m73673*0.1

nodelay

--

true

0

false

PMID: 15241548,7831356 Hb is an LPS binding protein

Go back
969.0, 857.0
21.0, 21.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000061423

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m155666*m36321*0.1

nodelay

--

true

0

false

PMID: 15241548 It (BPI) has both heparin- and LPS-binding capacity, and shares ~44% sequence homology with LBP

Go back
1037.0, 861.0
21.0, 21.0

p48

p49

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000061423 MO000018926

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m36321*m356124*0.1

nodelay

--

true

0

false

PMID: 15241548 It (BPI) has both heparin- and LPS-binding capacity, and shares ~44% sequence homology with LBP

Go back
532.0, 88.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018132 MO000016882

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1

m2828*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548,11500507 Unlike the membrane form, which requires LBP, sCD14 can directly bind LPS with a dissociation constant of 74 nM

Go back
1004.0, 1016.0
23.0, 23.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e98 e99

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m99*m100*0.1

nodelay

--

true

0

false

PMID: 15241548,9359845,11509640 Lactoferrin (Lf) is a multispecific protein which binds iron, heparin, proteoglycan, DNA, oligodeoxyncleotides and LPS

Go back
1096.0, 892.0
23.0, 23.0

p50

p51

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e98 MO000018926

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m99*m356124*0.1

nodelay

--

true

0

false

PMID: 15241548,9359845,11509640 Lactoferrin (Lf) is a multispecific protein which binds iron, heparin, proteoglycan, DNA, oligodeoxyncleotides and LPS

Go back
1172.0, 916.0
23.0, 23.0

p50

p52

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e102 e98

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m103*m99*0.1

nodelay

--

true

0

false

PMID: 15241548,9359845,11509640 Lactoferrin (Lf) is a multispecific protein which binds iron, heparin, proteoglycan, DNA, oligodeoxyncleotides and LPS

Go back
1121.0, 1125.0
21.0, 21.0

p53

p53

cso30:i:ME_DNABinding

cso30:i:CC_Extracellular

--

e98 e104

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m99*m105*0.1

nodelay

--

true

0

false

PMID: 15241548,9359845,11509640 Lactoferrin (Lf) is a multispecific protein which binds iron, heparin, proteoglycan, DNA, oligodeoxyncleotides and LPS

Go back
1160.0, 816.0
23.0, 23.0

p50

p54

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e98 e106

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m99*m107*0.1

nodelay

--

true

0

false

PMID: 15241548,9359845,11509640 Lactoferrin (Lf) is a multispecific protein which binds iron, heparin, proteoglycan, DNA, oligodeoxyncleotides and LPS

Go back
704.0, 820.0
23.0, 23.0

p50

p55

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e98 MO000016882

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1

m99*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548,9359845,11509640 Lactoferrin (Lf) is a multispecific protein which binds iron, heparin, proteoglycan, DNA, oligodeoxyncleotides and LPS

Go back
392.0, 1060.0
23.0, 23.0

p56

p56

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

G010329 e114 e149

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c177 : 1
stoichiometry:c252 : 1
stoichiometry:c178 : 1

m93309*m115*0.1

nodelay

--

true

0

false

PMID: 15241548 Like LBP, HBP enhances LPS-induced tumor necrosis factor-alpha (TNF-a) release by monocytes. PMID: 15241548 Furthermore, H2A inhibits the ligation of LPS to macrophages, and the LPS-induced production of TNF-a and nitric oxide.

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833.0, 1305.0
21.0, 21.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e109 e111

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m110*m112*0.1

nodelay

--

true

0

false

PMID: 15241548 Once released from neutrophils, HBP binds to endothelial cell surface proteoglycans, such as syndecans and glypican, and contributes to the progression of inflammation

Go back
717.0, 1305.0
21.0, 21.0

p57

p58

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e112 e109

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m113*m110*0.1

nodelay

--

true

0

false

PMID: 15241548 Once released from neutrophils, HBP binds to endothelial cell surface proteoglycans, such as syndecans and glypican, and contributes to the progression of inflammation

Go back
540.0, 1260.0
23.0, 23.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e109 MO000016882

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m110*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548,9199453 A synthetic peptide corresponding to residues 20?44 has been shown to possess the capacity to bind lipid A

Go back
744.0, 0.0
23.0, 23.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018132 e15

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m2828*m15*0.1

nodelay

--

true

0

false

PMID: 15241548,7534294 Lipoteichoic acid and phosphatidyl inositol also bind to sCD14

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128.0, 908.0
23.0, 23.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e115 MO000016882

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c181 : 1

m116*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548 Another group of neutrophil cationic proteins able to bind LPS involves proline-rich peptides. Indolicidin, Bac5 and prophenin represent three examples of such peptides

Go back
120.0, 1076.0
23.0, 23.0

p60

p61

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e117

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c183 : 1
stoichiometry:c184 : 1

m155666*m118*0.1

nodelay

--

true

0

false

PMID: 15241548 Another group of neutrophil cationic proteins able to bind LPS involves proline-rich peptides. Indolicidin, Bac5 and prophenin represent three examples of such peptides

Go back
180.0, 1224.0
23.0, 23.0

p60

p62

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e119 MO000016882

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m120*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548 Another group of neutrophil cationic proteins able to bind LPS involves proline-rich peptides. Indolicidin, Bac5 and prophenin represent three examples of such peptides

Go back
100.0, 460.0
23.0, 23.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e121

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1
stoichiometry:c190 : 1

m155666*m122*0.1

nodelay

--

true

0

false

PMID: 15241548,12928411 Another related component, the C1 inhibitor (a serine inhibitor of the classical complement pathway and of factor XII of the coagulation system), also interacts with LPS via its N-terminal mucin domain

Go back
144.0, 776.0
23.0, 23.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e123 MO000016882

e124

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c192 : 1
stoichiometry:c193 : 1

m124*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548 Lysozyme, a major cationic protein of leukocyte polymorphonuclear granules, was also found to bind LPS.

Go back
408.0, 676.0
23.0, 23.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000064893 MO000016882

e125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1
stoichiometry:c196 : 1

m39762*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548,9593692,10456890 In addition, SLPI was found to interact directly with different sulfated polysaccharides (dermatan, heparan and dextran sulfates), and with LPS

Go back
64.0, 564.0
23.0, 23.0

p65

p66

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e126

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c198 : 1
stoichiometry:c199 : 1

m155666*m127*0.1

nodelay

--

true

0

false

PMID: 15241548,9593692,10456890 In addition, SLPI was found to interact directly with different sulfated polysaccharides (dermatan, heparan and dextran sulfates), and with LPS

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36.0, 440.0
23.0, 23.0

p65

p67

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e128

e129

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c201 : 1
stoichiometry:c202 : 1

m155666*m129*0.1

nodelay

--

true

0

false

PMID: 15241548,9593692,10456890 In addition, SLPI was found to interact directly with different sulfated polysaccharides (dermatan, heparan and dextran sulfates), and with LPS

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37.0, 197.0
22.0, 22.0

p65

p68

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e130 MO000016882

e131

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m131*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548,9593692,10456890 In addition, SLPI was found to interact directly with different sulfated polysaccharides (dermatan, heparan and dextran sulfates), and with LPS

Go back
969.0, 169.0
22.0, 22.0

p69

p69

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e132

e133

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c207 : 1
stoichiometry:c208 : 1

m155666*m133*0.1

nodelay

--

true

0

false

PMID: 15241548,1663059 In saliva, histatins are small histidin-rich peptides (HRPs) with antimicrobial activity, secreted by epithelial cells of parotid and submandibular glands. They can bind LPS and neutralize its effects on monocytes

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404.0, 0.0
23.0, 23.0

p6

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018132 e16

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m2828*m16*0.1

nodelay

--

true

0

false

PMID: 15241548,7534294 Lipoteichoic acid and phosphatidyl inositol also bind to sCD14

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1149.0, 381.0
21.0, 21.0

p70

p70

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e134

e135

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c210 : 1
stoichiometry:c211 : 1

m155666*m135*0.1

nodelay

--

true

0

false

PMID: 15241548,7730641 Human a-defensins (HNP-1 to HNP-4) have been shown to interact with LPS, although less efficiently than BPI

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655.0, 795.0
25.0, 25.0

p71

p71

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000079001 MO000016882

e138

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c213 : 1
stoichiometry:c214 : 1

m286360*m155666*0.1

nodelay

--

true

0

false

PMID:15241548,9736536 The human cathelicidin hCAP18 carries a 37-residuea-helical peptide termed LL-37, with antimicrobial and LPS-binding activity

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577.0, 789.0
22.0, 22.0

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e136 MO000016882

e137

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c216 : 1
stoichiometry:c217 : 1

m137*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548 SMAP-29 contains two LPS binding sites: the highestaffinity site (RGLRRLGR) is located in the N-terminal region, and the lowest-affinity site (VLRIIRIA) is in the C-terminal region.

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299.0, 371.0
25.0, 25.0

p73

p73

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 e19

e139

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1
stoichiometry:c220 : 1

m13*m19*0.1

nodelay

--

true

0

false

PMID: 15241548,11500507 Unlike the membrane form, which requires LBP, sCD14 can directly bind LPS with a dissociation constant of 74 nM PMID: 15241548,12417309 A second function of LBP is to increase the interaction of LPS with soluble CD14 (sCD14) by forming a stable trimolecular complex

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406.0, 390.0
27.0, 27.0

p74

p74

cso30:i:ME_Internalization

cso30:i:CC_Cytosol

--

e139

e140 e19 e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c222 : 1
stoichiometry:c223 : 1
stoichiometry:c224 : 1

m140*0.1

nodelay

--

true

0

false

PMID: 15241548,11418686 After binding to the cell surface, LPS was found to be internalized and detectable in the cytoplasm of macrophages within seconds

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571.0, 419.0
25.0, 25.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e141 e140

e142

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c226 : 1
stoichiometry:c227 : 1

m142*m141*0.1

nodelay

--

true

0

false

PMID: 15241548, 11489964 It has been shown by Denlinger et al. that the C-terminal region of P2X7, which is located inside the cell after the second transmembrane domain, contains a motif (residues 573?590) which shares strong amino acid homology with the LPS binding sites of LBP and BPI. Furthermore, peptides derived from this sequence were shown to bind LPS in vitro, and to neutralize some LPS responses in macrophages.

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455.0, 455.0
26.0, 26.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e140 MO000023102

e143

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1
stoichiometry:c230 : 1

m141*m6914*0.1

nodelay

--

true

0

false

PMID: 15241548,11717582 Moesin, a cytoskeletal linker actin-binding protein associated with the cytoplasmic side of plasma membranes, can also bind LPS

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612.0, 356.0
23.0, 23.0

p77

p77

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e140 MO000017075

e144

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c232 : 1
stoichiometry:c233 : 1

m141*m1967*0.1

nodelay

--

true

0

false

PMID: 15241548,1573273 Moesin, a cytoskeletal linker actin-binding protein associated with the cytoplasmic side of plasma membranes, can also bind LPS , and at the cytoskeleton level, tubulin can do so as well

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519.0, 503.0
25.0, 25.0

p78

p78

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e140 e145

e146

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c235 : 1
stoichiometry:c236 : 1

m141*m146*0.1

nodelay

--

true

0

false

PMID: 15241548,12874245 It has also been suggested that LPS has the capacity to bind to selected subunits (C2 and N3) of the macrophage proteasome, with further activation of the proteasome chymotrypsin- like activity

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396.0, 444.0
23.0, 23.0

p79

p79

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e147 e140

e148

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c237 : 1
stoichiometry:c238 : 1
stoichiometry:c239 : 1

m148*m141*0.1

nodelay

--

true

0

false

PMID: 15241548,12667084 Another new class of LPS-binding molecules recently discovered by the present author¡Çs group is that of histones . The authors found that histones H1, H2A, H2B, H3 and H4 can all bind LPS.

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136.0, 340.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022131 MO000019394

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m6438*m3961*0.1

nodelay

--

true

0

false

PMID: 15241548 In contrast, cysteine residues such as Cys37, Cys95, Cys105 and Cys148 are important for forming a cell surface TLR4- MD-2 complex, in which MD-2 is docked to the extracellular leucine-rich repeats of TLR4.

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508.0, 336.0
23.0, 23.0

p79

p80

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e140 e149

e150

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c241 : 1
stoichiometry:c242 : 1

m141*m150*0.1

nodelay

--

true

0

false

PMID: 15241548,12667084 Another new class of LPS-binding molecules recently discovered by the present author¡Çs group is that of histones . The authors found that histones H1, H2A, H2B, H3 and H4 can all bind LPS.

Go back
608.0, 316.0
23.0, 23.0

p79

p81

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e140 e151

e152

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c244 : 1
stoichiometry:c245 : 1

m141*m152*0.1

nodelay

--

true

0

false

PMID: 15241548,12667084 Another new class of LPS-binding molecules recently discovered by the present author¡Çs group is that of histones . The authors found that histones H1, H2A, H2B, H3 and H4 can all bind LPS.

Go back
428.0, 592.0
23.0, 23.0

p79

p82

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e140 e153

e154

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1
stoichiometry:c247 : 1
stoichiometry:c248 : 1

m141*m154*0.1

nodelay

--

true

0

false

PMID: 15241548,12667084 Another new class of LPS-binding molecules recently discovered by the present author¡Çs group is that of histones . The authors found that histones H1, H2A, H2B, H3 and H4 can all bind LPS.

Go back
588.0, 644.0
23.0, 23.0

p79

p83

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e140 e155

e156

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c250 : 1
stoichiometry:c251 : 1

m141*m156*0.1

nodelay

--

true

0

false

PMID: 15241548,12667084 Another new class of LPS-binding molecules recently discovered by the present author¡Çs group is that of histones . The authors found that histones H1, H2A, H2B, H3 and H4 can all bind LPS.

Go back
504.0, 772.0
23.0, 23.0

p84

p84

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e140 e149

e157

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c255 : 1
stoichiometry:c253 : 1

m141*0.1

nodelay

--

true

0

false

PMID: 15241548 Furthermore, H2A inhibits the ligation of LPS to macrophages, and the LPS-induced production of TNF-a and nitric oxide.

Go back
1205.0, 465.0
21.0, 21.0

p70

p85

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e158

e159

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c256 : 1
stoichiometry:c257 : 1
stoichiometry:c258 : 1

m155666*m159*0.1

nodelay

--

true

0

false

PMID: 15241548,7730641 Human a-defensins (HNP-1 to HNP-4) have been shown to interact with LPS, although less efficiently than BPI

Go back
1121.0, 233.0
21.0, 21.0

p70

p86

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e160

e161

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c259 : 1
stoichiometry:c260 : 1
stoichiometry:c261 : 1

m155666*m161*0.1

nodelay

--

true

0

false

PMID: 15241548,7730641 Human a-defensins (HNP-1 to HNP-4) have been shown to interact with LPS, although less efficiently than BPI

Go back
1045.0, 145.0
21.0, 21.0

p70

p87

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e162

e163

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c262 : 1
stoichiometry:c263 : 1
stoichiometry:c264 : 1

m155666*m163*0.1

nodelay

--

true

0

false

PMID: 15241548,7730641 Human a-defensins (HNP-1 to HNP-4) have been shown to interact with LPS, although less efficiently than BPI

Go back
1092.0, 16.0
23.0, 23.0

p88

p88

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e164 MO000016882

e165

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c266 : 1
stoichiometry:c267 : 1

m165*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548,11036008,1406489 PMB binds to the LPS of Gram-negative bacteria, changes the packing order of LPS and increases the permeability of the outer membrane to a variety of molecules, including PMB itself (self-promoted uptake of PMB)

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1116.0, 84.0
23.0, 23.0

p89

p89

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e166 MO000016882

e167

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c268 : 1
stoichiometry:c269 : 1
stoichiometry:c270 : 1

m167*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548 Another bacterium-derived cyclic antimicrobial peptide, gramicidin S, binds LPS with a fourtimes lower affinity than PMB

Go back
64.0, 156.0
23.0, 23.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022131 MO000016882

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m6438*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548,11500507 It has been shown that MD-2 can directly bind LPS (Kd = 65 nM)

Go back
492.0, 1332.0
23.0, 23.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e168

e169

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c271 : 1
stoichiometry:c272 : 1
stoichiometry:c273 : 1

m155666*m169*0.1

nodelay

--

true

0

false

PMID: 15241548 A first group of molecules that recognize LPSs are lectins directed against the O-specific polysaccharide chain or the core region of particular LPSs

Go back
469.0, 89.0
21.0, 21.0

p91

p91

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e170

e173

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c274 : 1
stoichiometry:c275 : 1
stoichiometry:c276 : 1

m155666*m171*0.1

nodelay

--

true

0

false

PMID: 15241548 Other more extensively studied constitutive proteins of Gram-negative bacteria which interact with the lipid A region of LPS are FhuA, OmpT and MsbA.

Go back
201.0, 125.0
21.0, 21.0

p91

p92

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e171

e174

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c277 : 1
stoichiometry:c278 : 1
stoichiometry:c279 : 1

m155666*m172*0.1

nodelay

--

true

0

false

PMID: 15241548 Other more extensively studied constitutive proteins of Gram-negative bacteria which interact with the lipid A region of LPS are FhuA, OmpT and MsbA.

Go back
237.0, 145.0
21.0, 21.0

p91

p93

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 e172

e175

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c280 : 1
stoichiometry:c281 : 1
stoichiometry:c282 : 1

m155666*m173*0.1

nodelay

--

true

0

false

PMID: 15241548 Other more extensively studied constitutive proteins of Gram-negative bacteria which interact with the lipid A region of LPS are FhuA, OmpT and MsbA.

Go back
337.0, 1353.0
21.0, 21.0

p94

p94

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e176

e177

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c283 : 1
stoichiometry:c284 : 1
stoichiometry:c285 : 1

m155666*m177*0.1

nodelay

--

true

0

false

PMID: 15241548,1918062,2549069 A second group of molecules that interact with LPS are enzymes involved in its degradation, such as the lysosomal phosphatase involved in LPS catabolism and the granule acyloxyacyl hydrolase which removes the secondary acyl chains of LPS

Go back
425.0, 1385.0
21.0, 21.0

p94

p95

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e178 MO000016882

e179

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c286 : 1
stoichiometry:c288 : 1
stoichiometry:c287 : 1

m179*m155666*0.1

nodelay

--

true

0

false

PMID: 15241548,1918062,2549069 A second group of molecules that interact with LPS are enzymes involved in its degradation, such as the lysosomal phosphatase involved in LPS catabolism and the granule acyloxyacyl hydrolase which removes the secondary acyl chains of LPS

Go back
725.0, 105.0
21.0, 21.0

p96

p96

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000066851 MO000018240

e180

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c289 : 1
stoichiometry:c290 : 1
stoichiometry:c291 : 1

m41708*m2916*0.1

nodelay

--

true

0

false

PMID: 15241548 Phospholipid transfer protein (PLTP) and cholesteryl ester transfer protein (CETP) are lipid transport proteins found in plasma in association with apo A1.

Go back
601.0, 29.0
21.0, 21.0

p96

p97

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000018240 MO000069324

e181

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c292 : 1
stoichiometry:c293 : 1
stoichiometry:c294 : 1

m2916*m44168*0.1

nodelay

--

true

0

false

PMID: 15241548 Phospholipid transfer protein (PLTP) and cholesteryl ester transfer protein (CETP) are lipid transport proteins found in plasma in association with apo A1.

Go back
630.0, 186.0
22.0, 22.0

p98

p98

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e180

e182

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c295 : 1
stoichiometry:c296 : 1
stoichiometry:c297 : 1

m155666*m181*0.1

nodelay

--

true

0

false

PMID: 15241548,10768924,8647810 PLTP has been reported to bind LPS, and to transfer it from Gram-negative bacterial membranes or LPS aggregates to high-density lipoprotein (HDL) particles

Go back
274.9207155501065, 111.12350575178816

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
691.0, 74.7972783164867

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
125.0, 755.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 143.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1003.0588143418104, 730.3921346593751

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
980.6101943867961, 723.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 120.2016166138935

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.7611400011626, 124.94028500029067

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
919.0, 130.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
274.45305749400245, 137.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
137.0, 95.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
73.28153022668651, 113.3135053278742

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
560.0, 169.38887177195

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
105.0, 145.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
134.6266076028601, 136.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
92.75403719326738, 239.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.0, 143.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
305.0, 733.6676712350015

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
371.2371115759281, 726.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
421.0, 143.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
434.0, 734.9678578792928

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
477.0, 727.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
422.0, 143.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.0, 133.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
541.66581387621, 738.9722450967244

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.0, 731.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
423.0, 143.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.8102061011062, 738.79250626381

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 731.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 134.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.9488420383177, 241.9032775043543

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
934.0, 250.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 142.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.9180125442983, 434.14239981982416

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
369.54222307300796, 156.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
754.0, 439.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 467.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1164.9402850002907, 521.7611400011626

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1144.2103934880736, 514.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
979.0, 475.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1111.8161052203986, 674.4929882637098

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1096.0, 670.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 455.1119090269775

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1057.4437601569803, 405.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1061.0, 379.1346179391275

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
208.0, 100.19747067807054

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.0, 128.05498151932855

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.0, 47.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1035.0, 138.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.0, 143.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.0, 882.0335858293437

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
970.9287423733235, 878.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.0, 877.2433129922822

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1056.3021967939198, 594.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1049.0, 882.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1034.932389267097, 1030.0378827078446

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.0, 104.99438395098254

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
970.0, 1045.3692975529848

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1025.0, 1039.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1112.988652599722, 922.7488877161577

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1112.7298927661552, 594.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1119.0, 913.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.0, 945.0740528189224

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1149.0, 946.5548284865331

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.3737699510729, 933.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1134.1140386511927, 1061.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1132.0, 1154.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.0, 104.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1142.0, 1136.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1146.0, 846.9309183731222

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1181.5777087639997, 786.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1183.0, 833.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
734.1659503896211, 840.5565650582395

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
425.0, 143.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
727.0, 705.9737038588187

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
793.0, 1283.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
855.5066945971321, 1217.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.0, 1224.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
208.0, 15.353343668749812

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
662.0, 1312.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
743.8784275570199, 1283.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
703.7824545836681, 1250.5005297472794

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
571.0, 1272.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
421.0, 143.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
479.9308381279197, 1273.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
421.1754418849364, 1007.0

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
409.0379935830836, 1090.7360572745624

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
379.1055682552917, 1083.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
89.0, 929.352465419694

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
774.1870748873536, 21.51368105603954

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
146.68007734123844, 143.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
126.46073755074221, 931.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
138.30706726743742, 143.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
71.0, 1088.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
132.0, 1099.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
120.0, 1239.0573097607282

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
195.6232410134582, 143.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
192.0, 1247.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
128.3692657658187, 143.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
112.0, 415.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
767.0, 13.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
117.0, 483.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
78.0, 788.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
163.9893070104001, 143.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
106.3307167369338, 799.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
260.0, 706.6807975175808

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.0, 143.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.48643449810686, 699.0

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
89.89799158513148, 143.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
81.27270663753099, 594.6703849016671

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
77.0, 462.9437023256794

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.0, 50.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
208.0, 20.21439180520625

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
65.05809546893475, 142.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
54.43820581683027, 365.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
58.0, 463.0

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
38.0, 149.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
66.83500363512593, 134.0

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
53.0, 219.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 133.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
998.1039552742183, 189.67883398129163

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
991.0, 191.0

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 136.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
434.5093580761338, 18.758539701436916

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1168.4324545165464, 341.0

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1140.944100575847, 402.0

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.744611371106, 826.4411693765318

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.0, 143.0

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.0, 819.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.8978819417562, 817.3254053217655

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
423.0, 143.0

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.0, 811.0

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
317.09859662286067, 268.0

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.0, 351.0

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
80.98819714486025, 13.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.8446454055274, 387.0

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
249.0, 400.0

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.0, 405.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
257.60396260140516, 350.4859108504594

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 270.169784200017

c224

c224

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.491942767728, 339.0

c225

c225

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
535.0, 412.0

c226

c226

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 444.0

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
485.4929882637097, 419.0

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 487.4219507836356

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
136.0, 309.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.0, 481.0

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
535.0, 375.9877349668638

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
641.1070902829529, 383.1675379317294

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
627.0, 379.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
525.0, 419.0

c234

c234

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
535.631634032896, 535.8318433579009

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.0, 441.017155788605

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.0, 449.0

c237

c237

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.40564345206184, 413.0

c238

c238

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
384.4625622833173, 467.0

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
165.68695227583535, 301.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.43180206412, 366.98833818622006

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
421.0, 341.0

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
469.79245283018867, 317.22641509433964

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
535.0, 343.12974211278174

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
638.3456897029698, 336.1687288914772

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
611.2890551912172, 274.89546304620546

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
448.14622231744374, 419.0

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
386.0, 619.288244344552

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.0, 615.0

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
527.0, 419.0

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
159.0, 345.758472741024

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
618.9856387637262, 649.0

c250

c250

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
611.0, 664.0

c251

c251

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.04538714885166, 355.0

c252

c252

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
490.6625609418811, 795.0

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
516.1812565748395, 419.0

c254

c254

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
416.0, 355.0

c255

c255

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
431.0, 137.0

c256

c256

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1216.0, 420.0

c257

c257

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1216.0, 486.0

c258

c258

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 134.0

c259

c259

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
84.17689658476435, 186.34216099589983

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1135.1723892887157, 206.0

c260

c260

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1133.0, 254.0

c261

c261

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 132.0

c262

c262

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1073.3025460151594, 135.0

c263

c263

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1058.0, 95.92235181721476

c264

c264

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1121.9509135032858, 37.960404205360575

c265

c265

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.0, 31.19667055791947

c266

c266

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
362.0, 28.0

c267

c267

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1146.0385665808597, 105.80244401494711

c268

c268

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.0, 97.39659206308038

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
94.95549875014396, 133.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.9931665190606, 68.33058886637178

c270

c270

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
421.0, 143.0

c271

c271

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
522.9770261172122, 1345.6058500848515

c272

c272

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
514.0, 1355.0

c273

c273

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 109.72597146266098

c274

c274

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
333.0, 85.0

c275

c275

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
409.80674512266586, 83.7477787588058

c276

c276

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
229.9981507165726, 132.0

c277

c277

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
229.99451867013414, 136.29609328407903

c278

c278

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.0, 117.98553879239803

c279

c279

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
87.0, 179.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
265.92273397339466, 134.0

c280

c280

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
265.4117326169785, 163.0110163756475

c281

c281

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
258.0, 157.0

c282

c282

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
349.46203739766537, 143.0

c283

c283

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.0, 1369.1808205796483

c284

c284

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
327.5683142492632, 1374.0

c285

c285

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
413.0, 1350.0

c286

c286

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.0, 1406.0

c287

c287

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.0, 143.0

c288

c288

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
745.9691115068547, 63.0

c289

c289

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.51589011760902, 427.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
713.0, 67.0

c290

c290

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 126.0

c291

c291

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
629.8968438219807, 43.280569268429296

c292

c292

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
572.0, 31.0

c293

c293

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
607.0573097607281, 50.0

c294

c294

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 135.0

c295

c295

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
659.9932530560083, 193.0

c296

c296

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
652.0, 198.0

c297

c297

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
194.99914566424286, 73.87452706413444

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
169.90637435295267, 451.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
163.0, 498.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.84991412875183, 143.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
256.0, 502.9922778767137

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
258.0425797384169, 510.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1025.0, 190.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
853.0, 296.7562266522799

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.4829175920399, 298.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 69.96544109145819

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.0, 86.56325812751248

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
650.9975603804354, 36.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
854.6701273990304, 79.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 139.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
778.6263777987339, 382.5565957717955

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
775.0, 375.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
429.0, 143.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.8372338729644, 566.4799802105423

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
767.0, 559.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
427.0, 143.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
742.8653593550446, 638.4692513524756

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
739.0, 631.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.8954630462055, 58.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.9961491887296, 143.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.0, 647.3151918984429

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
253.67841260300818, 655.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
323.24570153357547, 143.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.0, 765.8522649890741

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
258.50741048025066, 775.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
425.0, 143.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.7950595939388, 794.4958416382906

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
743.0, 787.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
763.1252954816291, 989.8543371079376

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
647.0, 74.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.0, 989.4150626209072

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.0144992693705, 935.8466608896548

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
365.5752758638477, 143.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
255.0, 905.8203941659004

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
260.44705450312756, 913.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.0, 143.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
729.3022453936667, 933.6615707363007

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.1632313173002, 926.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
299.05105069365266, 143.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
255.0, 1071.0930991770963

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
706.8198090732454, 143.68836786808708

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
261.9005733234865, 1079.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 138.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
785.9908663274663, 333.3821718678353

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
778.0, 335.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 141.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
765.6175798544476, 409.44386520927674

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
751.0, 414.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
157.0, 596.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.35567115760455, 143.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
102.6462320697756, 599.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
667.0, 158.8198090732454

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
157.0, 309.71526480281614

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
362.9967687418885, 264.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.2469504755442, 263.9975603804354

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
307.1547815751688, 143.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
290.0, 266.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
253.01224348505514, 261.9211200117201

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
742.0, 261.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.8703990060646, 303.43416159666066

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
778.0, 271.2725185831543

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
754.3114838394541, 368.246876047126

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
567.32664860332, 149.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
733.0, 261.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
481.41753840099125, 256.9966855140005

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 93.84675723787703

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.0, 92.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
810.0, 103.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 141.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1060.0, 564.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.1554175279994, 641.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
132.48958931157614, 143.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
84.0, 736.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back