1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15283983.csml convertedTime:2009.07.01.10:46

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title What is disrupting IFN-alpha's antiviral activity?
Authors Mbow ML, Sarisky RT.
Affiliation Infectious Diseases Research, Centocor, 200 Great Valley Parkway, R-4-1,Malvern, PA 19087, USA.
Abstract Despite advances in treatment strategies for hepatitis C virus (HCV), asignificant proportion of patients fail to achieve viral clearance followingtreatment with pegylated interferon (IFN)-alpha plus ribavirin. Many of theseindividuals show elevated levels of tumor necrosis factor (TNF)-alpha comparedwith normal controls, and recent data have implicated this cytokine in thenegative regulation of IFN-alpha. Although a therapeutic opportunity forTNF-alpha antagonists might exist for reducing inflammation in chronic HCVdisease, further exploration is required to identify the key mediators ofresponsiveness to IFN-alpha. In particular, the interplay should be clarifiedbetween host response factors [e.g. IFN-alpha, IFN-gamma, suppressor of cytokinesignaling (SOCS), TNF-alpha and others] and pathogen-associated molecularpatterns [PAMPs, e.g. lipopolysaccharide (LPS) and CpG DNA] in HCV disease; thisinformation might guide future therapies aimed at improving IFN-alpharesponsiveness.
PMID 15283983
Model Abstract

Entity

G010228:IFN-beta G010329:TNF-alpha G010539:SOCS1 G011948:SOCS3 MO000000214:IL-1 MO000000289:TNF-alpha MO000007384:IL-6 MO000007694:IRF-3 MO000008179:PKR MO000016882:LPS MO000017247:IL-10 MO000017252:IL-10R MO000017264:IL-8 MO000018458:IL-6R MO000019394:TLR4 MO000042012:TLR9 MO000099682:CBP e1: e10:IFNA:IFNAR e11:Il-8 e12:Il-1 e13:TNF-alphaR e14:TNF-alpha:recpetor e15:shp2 e16:NS5A e17:NS5A:PKR e18:JAKs e19:IFNA:IFNAR:JAK e2: e20:STAT e21:STAT{p} e22:STAT{p} e23:ISGs e24:DNA:STAT{p} e25:mRNA e26:IFN-alpha e27:HCV E2 e28:HCV E2:PKR {inactive} e29:SOCS3 e3: e30:IFNAR:JAK:SOCS3 e31:SHP2 e32:IFNAR:JAK:SHP2 e33:ISG15 e34:IRF-3:ISG15 e35:IRF-3:CBP e36:p300 e37:IRF-3:p300 e38:SOCS1 e39:IFNAR:JAK:SOCS1 e4: e40:HCV core e41:LPS:TLR4 e42:CpG DNA e43:CpGDNA:TLR9 e44:IL-6:IL-6R e45:Il-6:IL-6R:JAKs e46:IL-10:IL-10R e47:Il-10:IL-10R:JAKs e48:IRF-3 e5:IFNalpha e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IFNAR e60: e61: e62: e7: e8: e9:

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p114 p115 p116 p117 p118 p119 p12 p120 p121 p122 p123 p124 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
270.0, 690.0
28.0, 28.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p17

p90

true true true true

csml-variable:Double

m93217

0

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
505.0, 597.0
30.0, 30.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p119

p2 p81

true true true true

csml-variable:Double

m93309

0

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
589.0, 705.0
30.5, 30.5

SOCS1

--

G010539

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p6 p8 p30 p32

p27 p82

true true true true

csml-variable:Double

m93501

0

false

infinite

0

unit false false false
TRANSFACG010539

--

Go back
611.0, 775.0
33.5, 33.5

SOCS3

--

G011948

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p7 p9 p31 p33

p20 p83

true true true true

csml-variable:Double

m94757

0

false

infinite

0

unit false false false
TRANSFACG011948

--

Go back
1031.0, 807.0
25.5, 25.5

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4

p58

true true true true

csml-variable:Double

m185

0

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
1030.0, 598.0
27.0, 27.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p5 p55

true true true true

csml-variable:Double

m230

0

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
724.0, 28.0
24.0, 24.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p100

p35 p42

true true true true

csml-variable:Double

m871

0

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
190.0, 1030.0
28.0, 28.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

p113

p25 p26 p41 p94

true true true true

csml-variable:Double

m977

0

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
269.0, 269.0
30.0, 30.0

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

p122

p11 p19 p76

true true true true

csml-variable:Double

m1055

0

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
1035.0, 875.0
26.0, 26.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

p109

p29 p59

true true true true

csml-variable:Double

m155666

0

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
857.0, 21.0
29.0, 29.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

p102

p38 p43

true true true true

csml-variable:Double

m2103

0

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
857.0, 105.0
30.0, 30.0

IL-10R

--

MO000017252

cso30:c:Protein

cso30:i:CC_CellComponent

--

p103

p38 p44

true true true true

csml-variable:Double

m2108

0

false

infinite

0

unit false false false
TRANSPATHMO000017252

--

Go back
1033.0, 721.0
29.5, 29.5

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

p57

true true true true

csml-variable:Double

m2120

0

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
627.0, 111.0
26.0, 26.0

IL-6R

--

MO000018458

cso30:c:Protein

cso30:i:CC_CellComponent

--

p101

p35 p67

true true true true

csml-variable:Double

m3096

0

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000018458

--

Go back
930.0, 890.0
28.0, 28.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

p110

p29 p60

true true true true

csml-variable:Double

m3961

0

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
931.0, 1063.0
26.0, 26.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

p112

p34 p63

true true true true

csml-variable:Double

m19828

0

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
231.0, 1179.0
26.0, 26.0

CBP

--

MO000099682

cso30:c:Protein

cso30:i:CC_CellComponent

--

p114

p25 p98

true true true true

csml-variable:Double

m72733

0

false

infinite

0

unit false false false
TRANSPATHMO000099682

--

Go back
90.75, 89.99690800911759
889.7889701147293, 1291.9735846065857

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
932.5, 393.0
23.6730980048235, 45.81889936417452

IFNA:IFNAR

--

e10

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p1

p2 p3 p4 p8 p9 p13 p52

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
496.0, 735.0
47.80276816608996, 25.49480968858131

Il-8

--

e11

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p117

p3 p99

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
504.0, 829.0
55.7439446366782, 29.730103806228374

Il-1

--

e12

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p118

p4 p84

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
921.5, 674.0
28.673110720562388, 44.112478031634446

TNF-alphaR

--

e13

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p124

p5 p56

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
924.5, 554.0
22.510852883139663, 43.56939267704451

TNF-alpha:recpetor

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p6 p7 p10 p54

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
523.0, 897.0
42.456747404844286, 22.643598615916957

shp2

--

e15

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p10

p22 p85

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
191.0, 309.5
34.848057959347955, 21.489635741597905

NS5A

--

e16

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p123

p11 p78

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
232.5, 498.0
23.491584735877346, 28.76520579903349

NS5A:PKR

--

e17

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p11

p79

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
866.5, 273.0
18.719661903803587, 30.35620849265448

JAKs

--

e18

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p106

p13 p36 p39 p50

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
933.5, 332.0
29.24536612222426, 40.80748761240595

IFNA:IFNAR:JAK

--

e19

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p13

p12 p21 p23 p28 p51

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
90.75, 89.99690800911759
889.7889701147293, 1291.9735846065857

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
657.0, 298.5
30.079999999999995, 22.56

STAT

--

e20

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p107

p12 p37 p40 p66

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
660.0, 379.5
30.08, 22.560000000000006

STAT{p}

--

e21

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p12 p37 p40

p14 p65

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
409.0, 584.5
30.08, 22.560000000000006

STAT{p}

--

e22

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p14

p15 p17 p18 p80

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
471.0, 661.5
57.24595383390819, 12.403289997346779

ISGs

--

e23

cso30:c:Dna

cso30:i:CC_Cytoplasm

--

--

p15 p88

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
396.0, 723.5
56.57495500128568, 16.029570583697605

DNA:STAT{p}

--

e24

cso30:c:Complex

cso30:i:CC_NuclearEnvelopeLumen

--

p15

p16 p87

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
404.0, 857.8546712802769
39.03114186851211, 20.816608996539795

mRNA

--

e25

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p16

p86

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
313.0, 754.0
54.083044982698965, 28.844290657439448

IFN-alpha

--

e26

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p18

p89

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
400.0, 246.0
15.797006548175865, 36.45463049579046

HCV E2

--

e27

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p121

p19 p75

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
342.5, 387.0
26.986335610731537, 33.044492584569234

HCV E2:PKR {inactive}

--

e28

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p19

p77

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
695.0, 455.0
17.876520112254447, 41.25350795135641

SOCS3

--

e29

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p20

p21 p70

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
108.54577940229457, 107.7926874114122
854.1974113101401, 1256.3820258019969

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
930.0, 480.0
28.23529411764706, 47.05882352941177

IFNAR:JAK:SOCS3

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p21

p12 p53

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
475.0, 339.0
17.876520112254447, 41.253507951356404

SHP2

--

e31

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p22

p23 p72

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
555.0, 95.0
25.411764705882355, 42.352941176470594

IFNAR:JAK:SHP2

--

e32

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p23

p12 p37 p40 p69

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
430.0, 977.5
60.0, 13.0

ISG15

--

e33

cso30:c:Dna

cso30:i:CC_Nucleolus

--

p116

p24 p92

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
294.0, 883.5
60.0, 17.0

IRF-3:ISG15

--

e34

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p24

p91

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
273.5, 1115.0
28.121313114480913, 34.434260956507245

IRF-3:CBP

--

e35

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p25

p97

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
352.0, 1179.5
32.32000000000001, 24.240000000000002

p300

--

e36

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p115

p26 p96

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
446.5, 1103.0
27.990668221963006, 34.27428761873021

IRF-3:p300

--

e37

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p26

p95

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
560.0, 409.0
16.769878391019642, 38.69971936389149

SOCS1

--

e38

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p27

p28 p71

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
408.0, 99.0
24.79411764705883, 41.32352941176472

IFNAR:JAK:SOCS1

--

e39

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p28

p12 p37 p40 p73

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
141.4679712965397, 138.9353013654275
788.3530275216503, 1194.0967978939657

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
507.0, 221.5
34.570336083719056, 21.31837391829342

HCV core

--

e40

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p108

p12 p37 p40 p74

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
932.5, 969.0
23.6730980048235, 45.81889936417452

LPS:TLR4

--

e41

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p29

p30 p31 p61

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1026.0, 1045.5
60.0, 13.0

CpG DNA

--

e42

cso30:c:Dna

cso30:i:CC_Extracellular

--

p111

p34 p62

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
936.5, 1137.0
23.856610392457796, 46.17408463056348

CpGDNA:TLR9

--

e43

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p34

p32 p33 p64

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
700.5, 99.0
22.041876781407584, 42.661696996272745

IL-6:IL-6R

--

e44

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p35

p36 p46

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
786.5, 101.0
26.759588915397327, 37.338961277298594

Il-6:IL-6R:JAKs

--

e45

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p36

p37 p68

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
937.5, 108.0
20.397062047796535, 39.47818460863846

IL-10:IL-10R

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p38

p39 p45

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
938.5, 177.0
26.759588915397327, 37.338961277298594

Il-10:IL-10R:JAKs

--

e47

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p39

p40 p47

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
326.0, 966.0
28.0, 28.0

IRF-3

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41

p24 p93

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1006.0, 209.5
28.480000000000004, 21.359999999999992

IFNalpha

--

e5

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p104

p1 p48

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
190.0, 529.4052038101905
579.3172406181851, 525.37708786044

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
252.5705771989845, 541.8558770143344
338.7441593186411, 509.1950420331164

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
197.55162138608438, 536.4174236686979
564.2139978460166, 511.35264814342617

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
198.6304244412392, 537.4962267238524
562.0563917357067, 509.1950420331164

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
190.0, 529.4052038101905
579.3172406181851, 525.37708786044

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
190.0, 529.4052038101905
579.3172406181851, 525.37708786044

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
198.6304244412392, 537.4962267238524
562.0563917357067, 509.1950420331164

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
612.8907976207229, 745.1658148411719
36.19255813288556, 32.763789467664864

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
517.9561287670913, 896.1982425628589
102.48629023971614, 92.77706274332208

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
190.0, 529.4052038101905
579.3172406181851, 525.37708786044

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
935.5, 252.0
25.383128295254828, 39.050966608084345

IFNAR

--

e6

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p105

p1 p49

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
326.541814019956, 762.8784404287545
18.346125793107976, 8.833319826311259

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
325.92918494951823, 736.5353903999331
62.79447971986582, 113.03006349575845

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
352.2722349783406, 810.0508788524597
9.802065127003436, 9.802065127003436

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
128.56128421843667, 105.64034368959287
801.1624512781975, 1135.226499228147

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
121.95834641656671, 136.0755189968549
787.5986390005611, 1143.5932238288146

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
104.84119006644553, 136.4852735364863
821.987865875782, 1183.2758853161592

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1001.0, 325.0
22.0, 22.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 e5

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m6*m5*0.1

nodelay

--

true

0

false

PMID: 15283983,9041265,8591843 IFN-a also confers immunomodulatory benefits. For example, binding to its cognate cell-surface receptor on immune cells can result in: a reduction in inflammation by inhibiting production of IL-1, IL-8 and tumor necrosis factor (TNF)-a

Go back
673.0, 893.0
21.0, 21.0

p6

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15283983 TNF-a stimulates expression of SOCS3 and SHP2, which bind to the JAK ?IFN receptor complex.

Go back
776.5, 68.5
15.0, 15.0

p100

p100

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

--

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
660.5, 108.5
15.0, 15.0

p101

p101

cso30:i:ME_UnknownProduction

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

MO000018458

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
900.5, 12.5
15.0, 15.0

p102

p102

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

--

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
904.5, 112.5
15.0, 15.0

p103

p103

cso30:i:ME_UnknownProduction

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

MO000017252

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
1052.5, 180.5
15.0, 15.0

p104

p104

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

--

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
908.5, 256.5
15.0, 15.0

p105

p105

cso30:i:ME_UnknownProduction

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
836.5, 280.5
15.0, 15.0

p106

p106

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

--

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
620.5, 320.5
15.0, 15.0

p107

p107

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

--

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
473.5, 166.5
NaN, NaN

p108

p108

cso30:i:-

cso30:i:CC_CellComponent

--

--

e40

true true true true

--

and

connectorcustom

--

1.0

--

0

false

--

Go back
1068.5, 852.5
15.0, 15.0

p109

p109

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

--

MO000016882

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
231.0, 415.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e16 MO000008179

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m16*m1055*0.1

nodelay

--

true

0

false

PMID: 15283983 NS5A binds to PKR in a region that overlaps the ISDR domain, and would be expected to suppress its function in vivo.

Go back
984.5, 896.5
15.0, 15.0

p110

p110

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

--

MO000019394

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
1044.5, 1012.5
15.0, 15.0

p111

p111

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

--

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
888.5, 1076.5
15.0, 15.0

p112

p112

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

--

MO000042012

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
168.5, 1044.5
15.0, 15.0

p113

p113

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

--

MO000007694

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
264.5, 1192.5
15.0, 15.0

p114

p114

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

--

MO000099682

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
400.5, 1184.5
15.0, 15.0

p115

p115

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

--

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
484.5, 1004.5
15.0, 15.0

p116

p116

cso30:i:ME_UnknownProduction

cso30:i:CC_Nucleoplasm

--

--

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
504.5, 716.5
15.0, 15.0

p117

p117

cso30:i:ME_UnknownProduction

cso30:i:CC_Nucleoplasm

--

--

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
480.5, 848.5
15.0, 15.0

p118

p118

cso30:i:ME_UnknownProduction

cso30:i:CC_Nucleoplasm

--

--

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
516.5, 552.5
15.0, 15.0

p119

p119

cso30:i:ME_UnknownProduction

cso30:i:CC_Nucleoplasm

--

--

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
792.0, 296.0
23.0, 23.0

p12

p12

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e19 e20 e30 e32 e39 e40

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c54 : 1
stoichiometry:c60 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c34 : 1

m19*m20*0.1

nodelay

--

true

0

false

PMID:15283983 Specifically, the signal transducer and activator of transcription (STAT) family of latent cytoplasmic transcription factors become tyrosine phosphorylated by the Janus family of tyrosine kinases (JAK) following binding of IFNs to their cognate multi-subunit transmembrane receptor PMID:15283983 This interaction prevents STAT activation and translocation to the nucleus, where it would otherwise induce antiviral response genes containing an ISRE. PMID: 15283983,9857039,11427497 treatment ofcultured mammalian cells with IFN-a or TNF-a results in induction of SOCS1 and SOCS3, the only two SOCS proteins reported to inhibit IFN-mediated antiviral and antiproliferative activities PMID: 15283983,12551851 Consistent with this observation, an initial report by Bode et al. claimed that overexpression of the HCV core protein inhibits IFN-a-induced tyrosine phosphorylation and activation of STAT1 in hepatic cells.

Go back
544.5, 648.5
15.0, 15.0

p120

p120

cso30:i:ME_UnknownProduction

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0

1.0*0.1

nodelay

--

true

0

false

--

Go back
420.5, 200.5
15.0, 15.0

p121

p121

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

--

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
292.5, 320.5
15.0, 15.0

p122

p122

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

--

MO000008179

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
176.5, 340.5
15.0, 15.0

p123

p123

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

--

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
896.5, 720.5
15.0, 15.0

p124

p124

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

--

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
792.0, 396.0
23.0, 23.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e18 e10

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m18*m10*0.1

nodelay

--

true

0

false

PMID: 15283983 TNF-a stimulates expression of SOCS3 and SHP2, which bind to the JAK ?IFN receptor complex.

Go back
549.0, 469.0
21.0, 21.0

p14

p14

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m21*0.1

nodelay

--

true

0

false

PMID:15283983 This interaction prevents STAT activation and translocation to the nucleus, where it would otherwise induce antiviral response genes containing an ISRE.

Go back
412.0, 656.0
23.0, 23.0

p15

p15

cso30:i:ME_DNABinding

cso30:i:CC_Cytoplasm

--

e22 e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m22*m23*0.1

nodelay

--

true

0

false

PMID: 15283983 Specifically, they (STAT) recognize DNA promoter elements to modulate type I IFN (IFN-a and IFN-b) genes selectively, and also recognize the interferon-stimulated response element (ISRE) in some ISGs, leading to induction of an antiviral state. PMID:15283983 This interaction prevents STAT activation and translocation to the nucleus, where it would otherwise induce antiviral response genes containing an ISRE.

Go back
412.0, 780.0
23.0, 23.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 15283983 Specifically, they (STAT) recognize DNA promoter elements to modulate type I IFN (IFN-a and IFN-b) genes selectively, and also recognize the interferon-stimulated response element (ISRE) in some ISGs, leading to induction of an antiviral state. PMID:15283983 This interaction prevents STAT activation and translocation to the nucleus, where it would otherwise induce antiviral response genes containing an ISRE.

Go back
332.0, 632.0
22.0, 22.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e22

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 15283983 Specifically, they (STAT) recognize DNA promoter elements to modulate type I IFN (IFN-a and IFN-b) genes selectively, and also recognize the interferon-stimulated response element (ISRE) in some ISGs, leading to induction of an antiviral state.

Go back
353.0, 665.0
22.0, 22.0

p17

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e22

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 15283983 Specifically, they (STAT) recognize DNA promoter elements to modulate type I IFN (IFN-a and IFN-b) genes selectively, and also recognize the interferon-stimulated response element (ISRE) in some ISGs, leading to induction of an antiviral state.

Go back
344.0, 316.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000008179 e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m1055*m27*0.1

nodelay

--

true

0

false

PMID: 15283983 Similar to NS5A, the HCV E2 protein was reported to contain a double-stranded (ds)RNA-activated protein kinase eukaryotic initiation factor 2a (PKR-eIF2a) homology domain, which might be capable of interacting with and inactivating PKR.

Go back
788.0, 668.0
23.0, 23.0

p2

p2

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010329 e10

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c10 : 1
stoichiometry:c7 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 15283983,9041265,8591843 IFN-a also confers immunomodulatory benefits. For example, binding to its cognate cell-surface receptor on immune cells can result in: a reduction in inflammation by inhibiting production of IL-1, IL-8 and tumor necrosis factor (TNF)-a

Go back
652.0, 516.0
23.0, 23.0

p20

p20

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G011948

e29

true true true true

--

and

mass

coefficient1:0.01
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m94757*0.01

nodelay

--

true

0

false

PMID: 15283983 TNF-a stimulates expression of SOCS3 and SHP2, which bind to the JAK ?IFN receptor complex.

Go back
776.0, 444.0
23.0, 23.0

p13

p21

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e19 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m19*m29*0.1

nodelay

--

true

0

false

PMID: 15283983 TNF-a stimulates expression of SOCS3 and SHP2, which bind to the JAK ?IFN receptor complex.

Go back
472.0, 448.0
23.0, 23.0

p20

p22

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e15

e31

true true true true

--

and

mass

coefficient1:0.01
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m15*0.01

nodelay

--

true

0

false

PMID: 15283983 TNF-a stimulates expression of SOCS3 and SHP2, which bind to the JAK ?IFN receptor complex.

Go back
556.0, 348.0
23.0, 23.0

p13

p23

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e31 e19

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m31*m19*0.1

nodelay

--

true

0

false

PMID: 15283983 TNF-a stimulates expression of SOCS3 and SHP2, which bind to the JAK ?IFN receptor complex.

Go back
387.0, 919.0
25.0, 25.0

p24

p24

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e33 e48

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c110 : 1
stoichiometry:c63 : 1

m33*m48*0.1

nodelay

--

true

0

false

PMID: 15283983,10048763 Characterization of IRF-3 showed regulatory activity by binding to the ISRE of ISG15 and interaction with the CBP/p300 coactivator

Go back
192.0, 1108.0
23.0, 23.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000007694 MO000099682

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m977*m72733*0.1

nodelay

--

true

0

false

PMID: 15283983,10048763 Characterization of IRF-3 showed regulatory activity by binding to the ISRE of ISG15 and interaction with the CBP/p300 coactivator

Go back
356.0, 1104.0
23.0, 23.0

p25

p26

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000007694 e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m977*m36*0.1

nodelay

--

true

0

false

PMID: 15283983,10048763 Characterization of IRF-3 showed regulatory activity by binding to the ISRE of ISG15 and interaction with the CBP/p300 coactivator

Go back
608.0, 480.0
23.0, 23.0

p27

p27

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010539

e38

true true true true

--

and

mass

coefficient1:0.01
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m93501*0.01

nodelay

--

true

0

false

PMID: 15283983,9857039,11427497 treatment ofcultured mammalian cells with IFN-a or TNF-a results in induction of SOCS1 and SOCS3, the only two SOCS proteins reported to inhibit IFN-mediated antiviral and antiproliferative activities

Go back
493.0, 285.0
21.0, 21.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e38 e19

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m38*m19*0.1

nodelay

--

true

0

false

PMID: 15283983,9857039,11427497 treatment ofcultured mammalian cells with IFN-a or TNF-a results in induction of SOCS1 and SOCS3, the only two SOCS proteins reported to inhibit IFN-mediated antiviral and antiproliferative activities

Go back
1020.0, 948.0
23.0, 23.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 15283983,14644140,10453004,11390452,12433373 SOCS1 and SOCS3 expression can be induced by various cytokines, and can also be induced by, and negatively regulate, LPS and CpG DNA, which are conserved bacterial components characterized as structural correlates of PAMP

Go back
812.0, 748.0
23.0, 23.0

p2

p3

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e11 e10

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c11 : 1
stoichiometry:c8 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 15283983,9041265,8591843 IFN-a also confers immunomodulatory benefits. For example, binding to its cognate cell-surface receptor on immune cells can result in: a reduction in inflammation by inhibiting production of IL-1, IL-8 and tumor necrosis factor (TNF)-a

Go back
596.0, 940.0
23.0, 23.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e41

G010539

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 15283983,14644140,10453004,11390452,12433373 SOCS1 and SOCS3 expression can be induced by various cytokines, and can also be induced by, and negatively regulate, LPS and CpG DNA, which are conserved bacterial components characterized as structural correlates of PAMP

Go back
628.0, 912.0
23.0, 23.0

p30

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e41

G011948

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 15283983,14644140,10453004,11390452,12433373 SOCS1 and SOCS3 expression can be induced by various cytokines, and can also be induced by, and negatively regulate, LPS and CpG DNA, which are conserved bacterial components characterized as structural correlates of PAMP

Go back
496.0, 916.0
23.0, 23.0

p30

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e43

G010539

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c84 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 15283983,14644140,10453004,11390452,12433373 SOCS1 and SOCS3 expression can be induced by various cytokines, and can also be induced by, and negatively regulate, LPS and CpG DNA, which are conserved bacterial components characterized as structural correlates of PAMP

Go back
516.0, 992.0
23.0, 23.0

p30

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e43

G011948

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c85 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 15283983,14644140,10453004,11390452,12433373 SOCS1 and SOCS3 expression can be induced by various cytokines, and can also be induced by, and negatively regulate, LPS and CpG DNA, which are conserved bacterial components characterized as structural correlates of PAMP

Go back
1008.0, 1128.0
23.0, 23.0

p29

p34

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e42 MO000042012

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m42*m19828*0.1

nodelay

--

true

0

false

PMID: 15283983,14644140,10453004,11390452,12433373 SOCS1 and SOCS3 expression can be induced by various cytokines, and can also be induced by, and negatively regulate, LPS and CpG DNA, which are conserved bacterial components characterized as structural correlates of PAMP

Go back
641.0, 29.0
21.0, 21.0

p35

p35

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

MO000018458 MO000007384

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m3096*m871*0.1

nodelay

--

true

0

false

PMID: 15283983,14630206 This same pathway can be induced by activation of other cytokine receptors including those for IL-6 and IL-10

Go back
793.0, 181.0
21.0, 21.0

p35

p36

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e44 e18

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m44*m18*0.1

nodelay

--

true

0

false

PMID: 15283983,14630206 This same pathway can be induced by activation of other cytokine receptors including those for IL-6 and IL-10

Go back
700.0, 172.0
23.0, 23.0

p37

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e45 e20 e32 e39 e40

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c115 : 1
stoichiometry:c99 : 1

m45*m20*0.1

nodelay

--

true

0

false

PMID: 15283983,14630206 This same pathway can be induced by activation of other cytokine receptors including those for IL-6 and IL-10

Go back
921.0, 45.0
21.0, 21.0

p35

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017247 MO000017252

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m2103*m2108*0.1

nodelay

--

true

0

false

PMID: 15283983,14630206 This same pathway can be induced by activation of other cytokine receptors including those for IL-6 and IL-10

Go back
857.0, 181.0
21.0, 21.0

p35

p39

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e46 e18

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m46*m18*0.1

nodelay

--

true

0

false

PMID: 15283983,14630206 This same pathway can be induced by activation of other cytokine receptors including those for IL-6 and IL-10

Go back
824.0, 808.0
23.0, 23.0

p2

p4

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e12 e10

MO000000214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c12 : 1
stoichiometry:c9 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 15283983,9041265,8591843 IFN-a also confers immunomodulatory benefits. For example, binding to its cognate cell-surface receptor on immune cells can result in: a reduction in inflammation by inhibiting production of IL-1, IL-8 and tumor necrosis factor (TNF)-a

Go back
788.0, 232.0
23.0, 23.0

p37

p40

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e47 e20 e32 e39 e40

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c111 : 1
stoichiometry:c114 : 1
stoichiometry:c116 : 1
stoichiometry:c108 : 1

m47*m20*0.1

nodelay

--

true

0

false

PMID: 15283983,14630206 This same pathway can be induced by activation of other cytokine receptors including those for IL-6 and IL-10

Go back
257.0, 1013.0
21.0, 21.0

p41

p41

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

MO000007694

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c109 : 1

m977*0.1

nodelay

--

true

0

false

PMID: 15283983,10048763 Characterization of IRF-3 showed regulatory activity by binding to the ISRE of ISG15 and interaction with the CBP/p300 coactivator

Go back
764.5, 20.5
15.0, 15.0

p42

p42

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

MO000007384

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1

m871*0.1

nodelay

--

true

0

false

--

Go back
840.5, 52.5
15.0, 15.0

p43

p43

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

MO000017247

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1

m2103*0.1

nodelay

--

true

0

false

--

Go back
888.5, 124.5
15.0, 15.0

p44

p44

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000017252

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1

m2108*0.1

nodelay

--

true

0

false

--

Go back
964.5, 112.5
15.0, 15.0

p45

p45

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e46

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1

m46*0.1

nodelay

--

true

0

false

--

Go back
728.5, 108.5
15.0, 15.0

p46

p46

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e44

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1

m44*0.1

nodelay

--

true

0

false

--

Go back
968.5, 176.5
15.0, 15.0

p47

p47

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e47

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1

m47*0.1

nodelay

--

true

0

false

--

Go back
1044.5, 220.5
15.0, 15.0

p48

p48

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e5

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1

m5*0.1

nodelay

--

true

0

false

--

Go back
964.5, 228.5
15.0, 15.0

p49

p49

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e6

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1

m6*0.1

nodelay

--

true

0

false

--

Go back
1020.0, 664.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000289 e13

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m230*m13*0.1

nodelay

--

true

0

false

PMID:15283983,9857039,11427497 treatment ofcultured mammalian cells with IFN-a or TNF-a results in induction of SOCS1 and SOCS3

Go back
896.5, 288.5
15.0, 15.0

p50

p50

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e18

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1

m18*0.1

nodelay

--

true

0

false

--

Go back
980.5, 344.5
15.0, 15.0

p51

p51

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e19

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1

m19*0.1

nodelay

--

true

0

false

--

Go back
964.5, 428.5
15.0, 15.0

p52

p52

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e10

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1

m10*0.1

nodelay

--

true

0

false

--

Go back
964.5, 512.5
15.0, 15.0

p53

p53

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e30

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1

m30*0.1

nodelay

--

true

0

false

--

Go back
960.5, 564.5
15.0, 15.0

p54

p54

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e14

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1

m14*0.1

nodelay

--

true

0

false

--

Go back
1064.5, 600.5
15.0, 15.0

p55

p55

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

MO000000289

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1

m230*0.1

nodelay

--

true

0

false

--

Go back
952.5, 648.5
15.0, 15.0

p56

p56

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e13

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1

m13*0.1

nodelay

--

true

0

false

--

Go back
1080.5, 732.5
15.0, 15.0

p57

p57

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

MO000017264

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1

m2120*0.1

nodelay

--

true

0

false

--

Go back
1068.5, 808.5
15.0, 15.0

p58

p58

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

MO000000214

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1

m185*0.1

nodelay

--

true

0

false

--

Go back
1080.5, 880.5
15.0, 15.0

p59

p59

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

MO000016882

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1

m155666*0.1

nodelay

--

true

0

false

--

Go back
667.0, 699.0
25.0, 25.0

p6

p6

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

G010539

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1

m14*0.1

nodelay

--

true

0

false

PMID:15283983,9857039,11427497 treatment ofcultured mammalian cells with IFN-a or TNF-a results in induction of SOCS1 and SOCS3

Go back
948.5, 852.5
15.0, 15.0

p60

p60

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000019394

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1

m3961*0.1

nodelay

--

true

0

false

--

Go back
964.5, 1008.5
15.0, 15.0

p61

p61

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e41

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1

m41*0.1

nodelay

--

true

0

false

--

Go back
1100.5, 1028.5
15.0, 15.0

p62

p62

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e42

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1

m42*0.1

nodelay

--

true

0

false

--

Go back
980.5, 1072.5
15.0, 15.0

p63

p63

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

MO000042012

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1

m19828*0.1

nodelay

--

true

0

false

--

Go back
964.5, 1184.5
15.0, 15.0

p64

p64

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e43

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1

m43*0.1

nodelay

--

true

0

false

--

Go back
700.5, 396.5
15.0, 15.0

p65

p65

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e21

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1

m21*0.1

nodelay

--

true

0

false

--

Go back
644.5, 324.5
15.0, 15.0

p66

p66

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e20

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1

m20*0.1

nodelay

--

true

0

false

--

Go back
664.5, 140.5
15.0, 15.0

p67

p67

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

MO000018458

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1

m3096*0.1

nodelay

--

true

0

false

--

Go back
820.5, 112.5
15.0, 15.0

p68

p68

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e45

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1

m45*0.1

nodelay

--

true

0

false

--

Go back
580.5, 68.5
15.0, 15.0

p69

p69

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e32

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1

m32*0.1

nodelay

--

true

0

false

--

Go back
679.0, 779.0
25.0, 25.0

p6

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

G011948

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15283983 TNF-a stimulates expression of SOCS3 and SHP2, which bind to the JAK ?IFN receptor complex.

Go back
720.5, 444.5
15.0, 15.0

p70

p70

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e29

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1

m29*0.1

nodelay

--

true

0

false

--

Go back
592.5, 400.5
15.0, 15.0

p71

p71

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e38

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1

m38*0.1

nodelay

--

true

0

false

--

Go back
440.5, 364.5
15.0, 15.0

p72

p72

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e31

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1

m31*0.1

nodelay

--

true

0

false

--

Go back
424.5, 72.5
15.0, 15.0

p73

p73

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e39

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1

m39*0.1

nodelay

--

true

0

false

--

Go back
512.5, 256.5
15.0, 15.0

p74

p74

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e40

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1

m40*0.1

nodelay

--

true

0

false

--

Go back
432.5, 256.5
15.0, 15.0

p75

p75

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e27

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1

m27*0.1

nodelay

--

true

0

false

--

Go back
280.5, 228.5
15.0, 15.0

p76

p76

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

MO000008179

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1

m1055*0.1

nodelay

--

true

0

false

--

Go back
376.5, 424.5
15.0, 15.0

p77

p77

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e28

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1

m28*0.1

nodelay

--

true

0

false

--

Go back
204.5, 256.5
15.0, 15.0

p78

p78

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e16

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1

m16*0.1

nodelay

--

true

0

false

--

Go back
276.5, 500.5
15.0, 15.0

p79

p79

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e17

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1

m17*0.1

nodelay

--

true

0

false

--

Go back
575.0, 571.0
23.0, 23.0

p8

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e10

G010539

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m10*0.1

nodelay

--

true

0

false

PMID:15283983,9857039,11427497 treatment ofcultured mammalian cells with IFN-a or TNF-a results in induction of SOCS1 and SOCS3

Go back
424.5, 556.5
15.0, 15.0

p80

p80

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e22

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1

m22*0.1

nodelay

--

true

0

false

--

Go back
536.5, 572.5
15.0, 15.0

p81

p81

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

G010329

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1

m93309*0.1

nodelay

--

true

0

false

--

Go back
616.5, 684.5
15.0, 15.0

p82

p82

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

G010539

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1

m93501*0.1

nodelay

--

true

0

false

--

Go back
584.5, 800.5
15.0, 15.0

p83

p83

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

G011948

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1

m94757*0.1

nodelay

--

true

0

false

--

Go back
500.5, 868.5
15.0, 15.0

p84

p84

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e12

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1

m12*0.1

nodelay

--

true

0

false

--

Go back
556.5, 876.5
15.0, 15.0

p85

p85

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e15

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1

m15*0.1

nodelay

--

true

0

false

--

Go back
448.5, 856.5
15.0, 15.0

p86

p86

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e25

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1

m25*0.1

nodelay

--

true

0

false

--

Go back
440.5, 748.5
15.0, 15.0

p87

p87

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e24

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1

m24*0.1

nodelay

--

true

0

false

--

Go back
472.5, 628.5
15.0, 15.0

p88

p88

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e23

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1

m23*0.1

nodelay

--

true

0

false

--

Go back
324.5, 792.5
15.0, 15.0

p89

p89

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e26

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1

m26*0.1

nodelay

--

true

0

false

--

Go back
524.0, 680.0
23.0, 23.0

p8

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e10

G011948

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m10*0.1

nodelay

--

true

0

false

PMID:15283983,9857039,11427497 treatment ofcultured mammalian cells with IFN-a or TNF-a results in induction of SOCS1 and SOCS3

Go back
280.5, 652.5
15.0, 15.0

p90

p90

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

G010228

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1

m93217*0.1

nodelay

--

true

0

false

--

Go back
312.5, 856.5
15.0, 15.0

p91

p91

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e34

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1

m34*0.1

nodelay

--

true

0

false

--

Go back
448.5, 1004.5
15.0, 15.0

p92

p92

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e33

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1

m33*0.1

nodelay

--

true

0

false

--

Go back
356.5, 992.5
15.0, 15.0

p93

p93

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e48

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1

m48*0.1

nodelay

--

true

0

false

--

Go back
192.5, 992.5
15.0, 15.0

p94

p94

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

MO000007694

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1

m977*0.1

nodelay

--

true

0

false

--

Go back
488.5, 1108.5
15.0, 15.0

p95

p95

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e37

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1

m37*0.1

nodelay

--

true

0

false

--

Go back
376.5, 1216.5
15.0, 15.0

p96

p96

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e36

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1

m36*0.1

nodelay

--

true

0

false

--

Go back
284.5, 1164.5
15.0, 15.0

p97

p97

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e35

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1

m35*0.1

nodelay

--

true

0

false

--

Go back
240.5, 1220.5
15.0, 15.0

p98

p98

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

MO000099682

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1

m72733*0.1

nodelay

--

true

0

false

--

Go back
488.5, 776.5
15.0, 15.0

p99

p99

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e11

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1

m11*0.1

nodelay

--

true

0

false

--

Go back
961.0, 285.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.9154085227223, 437.0

c10

c10

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
886.0, 41.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
886.0, 71.80370958807373

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
934.0, 66.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
884.2469504755443, 136.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
869.6736551832275, 209.97158633485898

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
878.0, 192.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
818.6187017701216, 200.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
687.0, 253.66196615570553

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.1740993536283, 255.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
278.0, 993.1369251194046

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
829.3197686025272, 439.0

c11

c11

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
354.0, 947.0659023220582

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.0, 123.0

c111

c111

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
580.0, 122.0

c112

c112

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
433.0, 123.0

c113

c113

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
433.0, 124.0

c114

c114

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
542.0, 188.00469903646567

c115

c115

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
542.0, 233.0

c116

c116

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
748.0, 33.2573305919324

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
712.0, 118.39028267127239

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
653.0, 134.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.0365142643494, 439.0

c12

c12

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
800.0, 120.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.0, 120.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.0, 125.2573305919324

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.9691115068547, 46.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.0, 191.40637629063903

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1034.0, 224.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.0, 250.4

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
885.0, 291.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
963.0, 352.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
956.0, 425.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1035.4133125023502, 625.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
944.0, 504.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
947.0, 573.5699763999032

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1057.0, 606.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1063.0, 737.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.0, 670.5538553641524

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1057.0, 817.6643638388299

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1061.0, 888.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.0, 875.7181105699019

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
956.0, 1001.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1077.0, 1040.5298221281348

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
950.0, 679.676232709847

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
957.0, 1077.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.0, 1177.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.0, 1117.53215208419

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
374.0, 1204.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
289.0, 1149.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
245.0, 1205.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
201.72428596834015, 1015.9671456517416

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
340.0, 980.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
458.1313708498985, 991.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
321.6643638388299, 879.972366065959

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.5418346747588, 593.7695813052284

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.0, 865.9531617649475

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.5876987549067, 859.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
550.0, 896.2063309876478

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
607.2829318197008, 799.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
614.0, 698.3409919128368

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.34601022525817, 760.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 740.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
334.56892908110547, 783.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
285.0, 675.9671456517416

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
427.0, 579.795129565557

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
699.062176823857, 582.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
489.17160007563183, 650.8262546692157

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.0, 594.3148177390107

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
577.0, 417.23999152002546

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 396.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
713.0, 465.2680368629481

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.9402850002907, 317.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.5699763999032, 243.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
416.0, 264.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
463.50674493453687, 363.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
369.0, 417.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
627.9551113054329, 713.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.0, 509.758472741024

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
209.0, 279.9751851892278

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
285.0, 251.974522228289

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
425.0, 95.5183473879075

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
578.0, 91.02316458331508

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.2494651199621, 23.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
754.4795369723441, 53.692078497214744

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
660.4906334205524, 115.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.0, 120.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1039.2469504755443, 194.0

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
709.9987028429207, 586.0

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
852.0, 288.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1066.6568542494924, 868.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
966.0, 904.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1053.0, 1028.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
904.0, 1079.4567140814584

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.0, 1192.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
176.0, 1050.197769023179

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.72987951680994, 1198.0613012044826

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
521.550416732923, 568.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
512.0, 724.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
653.0, 792.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0, 848.9922778767136

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
474.1754418849364, 996.0856580228888

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
191.0, 337.2469504755442

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
291.7339445046936, 306.5183473879075

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
416.7540371932674, 216.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.0, 178.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

0,

--

Go back
912.0, 716.6568542494924

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
924.0, 266.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
636.0, 319.15135438863337

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1013.5096012338028, 231.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.2439311583398, 421.0

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
588.0, 594.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
553.627204573173, 424.0

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
546.0, 703.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.8868033008508, 591.0

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.9969153652218, 904.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
212.0, 331.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.1274319850065, 299.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.0, 440.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
815.12679808717, 303.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
961.1972186206572, 347.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.9896781549733, 409.40625482143935

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
815.0, 360.88443420460845

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.6392587538185, 313.3752317133721

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
687.0, 308.1523533170974

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
696.7465670172733, 316.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
576.3409919128368, 402.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
443.0740528189224, 489.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.0, 607.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
443.0, 668.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.0, 679.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
535.0, 616.0

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
424.0, 740.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
424.0, 803.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
360.91478670167504, 605.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
302.5766271463345, 654.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
376.8350918509939, 607.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
345.96750495905803, 687.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
299.0, 293.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
371.03358582934374, 274.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.0, 339.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
630.0, 546.9274567054412

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
544.0, 749.0

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
673.0, 494.2905467105794

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
805.7018722063407, 361.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
713.0, 460.85296421844834

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
799.0, 459.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.3268176844322, 322.2536009994179

c54

c54

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
486.07924488898703, 478.9268676329049

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
484.0, 388.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
493.0, 360.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.9979694303767, 352.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
568.0, 145.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
560.0, 821.6343598516645

c6

c6

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.0, 126.0

c60

c60

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
218.0, 1029.3526867907

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
418.020613557655, 948.2680368629482

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
347.1248421192625, 904.6382172523894

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
204.0, 1058.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
213.92208991706048, 1137.9726042969965

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
215.0, 1122.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
218.0, 1050.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.0, 1135.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
379.0, 1116.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
811.0, 618.1465952605031

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
605.0, 510.98085514092867

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
582.016075241693, 445.2320934821034

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
512.4952317018954, 313.196065268608

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.9370546234986, 298.0015807024891

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.4375346821403, 147.2238047668166

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
433.0, 126.0

c75

c75

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
542.0, 237.0

c76

c76

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1036.6648611557189, 901.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
958.0, 913.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
963.4906334205524, 964.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
835.0, 738.8437524961076

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
626.9420532305062, 953.9611401998702

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
604.1568325994756, 743.9984625732538

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
658.807537202421, 927.7442370345834

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
630.696375757411, 816.9696336681487

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
514.0, 743.264855902464

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.0, 816.2403419158106

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1028.0081344481973, 1059.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
957.0, 1087.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
967.7218109753595, 1143.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.4983474601235, 1010.7883302113022

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
847.0, 820.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.0793457790559, 937.7259714626609

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
642.0, 57.91432290859588

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
670.0, 40.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
660.0, 50.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
723.0, 128.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
816.8139928513253, 208.38948142085005

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.3716911948197, 145.99136068862452

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
729.4961229707417, 130.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
676.0, 202.62532970349073

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
678.4048516650215, 195.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back