1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15331118.csml convertedTime:2009.07.01.10:46

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Mechanism of age-associated up-regulation in macrophage PGE2 synthesis.
Authors Wu D, Meydani SN.
Affiliation Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition ResearchCenter on Aging at Tufts University, Boston, MA 02111, USA. dayong.wu@tufts.edu
Abstract Many physiological functions of the body change during the aging process.Dysregulated immune and inflammatory responses have been well documented in bothhumans and animals. The investigation into the cellular and molecular mechanismunderlying these disorders has provided compelling evidence that up-regulatedcyclooxygenase (COX)-2 and its product, particularly prostaglandin (PG)E2, playa critical role in the age-associated dysregulation of the immune andinflammatory responses. In particular, several studies have shown that increasedPGE2 production in old macrophages (Mphi) contributes to the suppression of Tcell function with aging. Furthermore, interventions targeted at decreasing PGE2production have been shown to enhance T cell-mediated function. COX-2 and itscatalytic products are also suggested to play a key role in age-relatedneurodegenerative diseases such as Alzheimer's and Parkinson's disease.Administration of anti-inflammatory drugs which inhibit COX activity has beenshown, by some investigators, to be beneficial in preventing and treating thesediseases. It is, thus, important to understand the underlying mechanisms ofage-related COX-2 up-regulation and to delineate the factors, which contributeto this age-related change. This review focuses on the regulation of PGE2production in murine Mphi; the age-associated changes in COX-2 expression; andits implication for certain disorders observed in the aged immune system andbrain. Increased PGE2 production has been shown to be mainly due to an increasein COX activity, which is, in turn, due to an increase in COX-2 protein and mRNAexpression. Elevated COX-2 mRNA represents a higher transcription rate ratherthan an altered stability of COX-2 mRNA. Upon stimulation, Mphi from old micegenerate more ceramide, a sphingolipid, than those from young mice. Ceramide hasbeen shown to induce, by itself, and also augment, LPS-stimulated COX-2expression and PGE2 production. Several lines of evidence indicate that thehigher ceramide levels in old Mphi are an important contributor to theage-associated up-regulation of COX-2 in Mphi. Ceramide up-regulates COX-2transcription by increasing activation of transcription factor NF-kappaB.Further understanding of molecular mechanisms involved in COX-2 up-regulationwill help in delineating fundamental age-related changes, which lead to thedevelopment of immune and neurological disorders in the aged.
PMID 15331118
Model Abstract

Entity

e1: e10: e11:TCR e12:MHC e13:antigen:TCR e14:anti-TCR antibody e15:antibody:TCR e16:FYN e17:FYN{active} e18:LCK e19:LCK{active} e2: e20:CD3zeta e21:CD3zeta{p} e22:ZAP70 e23:CD3zeta{p}:ZAP70 e25:LAT e26:LAT{p} e27:cytokine genes e28:Unknown protein{active} e29:CD14 e3: e30:LPS e31:LPS:CD14 e32:LPS:CD14:TLR4:MYD88 e33:TLR4 e34:LPS:CD14:TLR4 e35:TLR2 e36:LPS:CD14:TLR2 e37:MYD88 e38:LPS:CD14:TLR2:MYD88 e39:IRAK e4: e40:LPS:CD14:TLR4:MYD88:IRAK e41:LPS:CD14:TLR2:MYD88:IRAK e42:LPS:CD14:TLR4:MYD88:IRAK{active} e43:TRAF6 e44:TRAF6{p} e45:LPS:CD14:TLR4:MYD88:IRAK{active}:TRAF6{p} e46:LPS:CD14:TLR2:MYD88:IRAK{active} e47:LPS:CD14:TLR2:MYD88:IRAK{active}:TRAF6{p} e48:IKKalpha:IKK-beta:IKK-gamma e49:IKK-alpha:IKK-beta:IKK-gamma{active} e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:antigen:MHC e60: e61: e62: e63:Ikappa-B:NF-kappaB e64:IkappaB{p}:NF-kappaB e65:protein remnants e66:p50:p65 e67:p50:p65 e68:COX2 e69:COX2:p50:p65 e7: e70:NIK e71:NIK{active} e72:COX2 e73:COX2 e74:Arachidonic acid e75:PGH2 e76:PGE2 e77:Sphingolipid e78:ceramide e79:SMase e8: e80:ERK e81:ERK{active} e82:JNK e83:JNK{active} e84:p38 e85:p38{active} e86:Unknown protein e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p6 p7
Model Detail
210.44891412709092, 58.82869668124192
1024.8847828220987, 1517.9738884697397

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
220.3236076491993, 82.03022467709238
993.4272014149624, 1425.4959362443717

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1180.5, 369.0
39.0, 60.0

TCR

--

e11

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1 p2

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1350.5, 316.0
35.32161687170474, 54.340949033391915

MHC

--

e12

cso30:c:Protein

cso30:i:CC_Extracellular

--

p1

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1182.5, 494.0
34.513922385441795, 66.80114010085508

antigen:TCR

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1426.0, 486.5
52.12653778558876, 33.88224956063269

anti-TCR antibody

--

e14

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1184.5, 645.0
31.0, 60.0

antibody:TCR

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1041.0, 378.0
21.926099158091674, 50.598690364826936

FYN

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3 p49

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1088.0, 439.0
23.908325537885872, 55.17305893358279

FYN{active}

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1036.0, 504.0
23.65294667913938, 54.58372310570626

LCK

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4 p50

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
990.0, 563.0
20.770813844714684, 47.932647333956965

LCK{active}

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
210.44891412709092, 58.82869668124192
1024.8847828220987, 1517.9738884697397

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
979.0, 399.5
49.3499698128396, 30.432481384584424

CD3zeta

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5 p6

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
926.0, 625.0
43.78048780487805, 35.02439024390244

CD3zeta{p}

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

p5 p6

p7

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1136.5, 738.0
31.020728516804194, 50.30388408130409

ZAP70

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1170.5, 861.0
43.0, 60.0

CD3zeta{p}:ZAP70

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1136.0, 923.5
40.15999999999999, 30.119999999999997

LAT

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
929.0, 825.0
46.21951219512194, 36.975609756097555

LAT{p}

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
853.0, 1089.0
53.25259515570934, 28.401384083044984

cytokine genes

--

e27

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p11

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
851.0, 890.5
50.86115992970123, 33.059753954305805

Unknown protein{active}

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
260.5, 61.0
39.0, 60.0

CD14

--

e29

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p13

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
230.94660978353295, 79.73742792738169
983.889391509215, 1476.1564259774605

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
126.0, 30.0
60.0, 34.0

LPS

--

e30

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p13

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
336.5, 65.0
31.0, 60.0

LPS:CD14

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
694.0, 45.0
36.0, 60.0

LPS:CD14:TLR4:MYD88

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
403.5, 73.0
33.196836555360285, 51.072056239015815

TLR4

--

e33

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p14

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
474.5, 61.0
43.0, 60.0

LPS:CD14:TLR4

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
543.5, 73.0
33.35676625659051, 51.31810193321616

TLR2

--

e35

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p15

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
606.5, 58.0
43.0, 60.0

LPS:CD14:TLR2

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
514.0, 164.5
44.81546572934973, 29.130052724077334

MYD88

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16 p17

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
766.0, 41.0
36.0, 60.0

LPS:CD14:TLR2:MYD88

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
665.0, 214.0
21.780168381665106, 50.26192703461178

IRAK

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p18 p19

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
268.8673467479505, 116.32770760812582
908.0479175803791, 1402.9758666159717

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
846.0, 49.0
36.0, 60.0

LPS:CD14:TLR4:MYD88:IRAK

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
946.0, 49.0
36.0, 60.0

LPS:CD14:TLR2:MYD88:IRAK

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1046.0, 49.0
36.0, 60.0

LPS:CD14:TLR4:MYD88:IRAK{active}

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
939.0, 219.5
42.24, 31.680000000000003

TRAF6

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p21 p24

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1059.0, 222.0
41.58536585365854, 33.26829268292682

TRAF6{p}

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1162.0, 45.0
36.0, 60.0

LPS:CD14:TLR4:MYD88:IRAK{active}:TRAF6{p}

--

e45

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
214.0, 305.0
36.0, 60.0

LPS:CD14:TLR2:MYD88:IRAK{active}

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1170.0, 189.0
36.0, 60.0

LPS:CD14:TLR2:MYD88:IRAK{active}:TRAF6{p}

--

e47

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
557.5, 461.0
37.373463020737745, 52.14901816847128

IKKalpha:IKK-beta:IKK-gamma

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p26

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
663.5, 540.0
33.656634244815564, 46.96274545788219

IKK-alpha:IKK-beta:IKK-gamma{active}

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1359.5, 141.0
224.16900746864582, 324.09976983418676

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
427.39293847644143, 934.2424093507116
557.3517259909099, 515.592588304549

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
487.5910764791839, 946.4612041398051
325.9002643596756, 499.7119131000966

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
434.65823099401376, 941.1240352726406
542.821140955766, 501.8293364606904

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
435.69612992509553, 942.1827469529375
540.7453430936017, 499.7119131000966

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
427.39293847644143, 934.2424093507116
557.3517259909099, 515.592588304549

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
427.39293847644143, 934.2424093507116
557.3517259909099, 515.592588304549

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
435.69612992509553, 942.1827469529375
540.7453430936017, 499.7119131000966

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
834.249319460495, 1145.9847454100736
34.82027346858305, 32.15360434367858

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
742.9142135252989, 1294.2043806516294
98.6003984527681, 91.0492045055261

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
427.39293847644143, 934.2424093507116
557.3517259909099, 515.592588304549

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1354.1568734926548, 204.59394869546148
35.343126507344884, 68.40605130453847

antigen:MHC

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane

--

--

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
558.7576042901926, 1163.367495216624
17.65051021979566, 8.668810151423145

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
558.1682037927444, 1137.5150519677018
60.413550988438836, 110.92501812619251

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
583.5124251830166, 1209.6614052205107
9.430407959170932, 9.619513767041083

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
529.5, 656.0
37.16030661556407, 45.50241626395601

Ikappa-B:NF-kappaB

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p28 p45

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
735.5, 658.0
36.6703882686219, 44.90251624729213

IkappaB{p}:NF-kappaB

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
745.0, 729.0
38.27110855829983, 36.995404939689834

protein remnants

--

e65

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p29

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
670.0, 802.0
44.1049723756906, 49.00552486187846

p50:p65

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
692.0, 957.0
40.276243093922645, 44.75138121546962

p50:p65

--

e67

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
496.0, 1077.5
56.347438752783965, 19.721603563474385

COX2

--

e68

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p31

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
614.0, 1142.0
60.0, 26.0

COX2:p50:p65

--

e69

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
223.91440529360227, 64.93714360914016
1005.0926704568795, 1452.7493147186653

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
604.5, 362.0
26.433890118736162, 42.8657677601127

NIK

--

e70

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p27 p32

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
804.5, 382.0
30.93882068826725, 50.17106057556853

NIK{active}

--

e71

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
642.0, 1263.0
60.0, 32.0

COX2

--

e72

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
339.0, 1265.5
42.03866432337434, 27.32513181019332

COX2

--

e73

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
258.0, 1086.0
60.0, 34.0

Arachidonic acid

--

e74

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p35

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
350.0, 1026.0
60.0, 34.0

PGH2

--

e75

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
298.0, 898.0
60.0, 34.0

PGE2

--

e76

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
230.0, 410.0
60.0, 34.0

Sphingolipid

--

e77

cso30:c:SmallMolecule

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p37

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
282.0, 570.0
60.0, 34.0

ceramide

--

e78

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
327.0, 405.5
42.70650263620386, 27.759226713532513

SMase

--

e79

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p37

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
227.50520293800548, 90.57676521106848
964.1973752227465, 1428.0887602692108

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
821.0, 467.0
21.14780168381665, 48.802619270346106

ERK

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p38 p47

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
824.0, 600.0
23.17867165575304, 53.48924228250701

ERK{active}

--

e81

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
888.0, 381.0
23.13002806361085, 53.37698783910196

JNK

--

e82

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p40 p48

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
868.0, 700.0
23.1178671655753, 53.348924228250695

JNK{active}

--

e83

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
421.0, 378.0
21.780168381665106, 50.26192703461178

p38

--

e84

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p42 p46

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
422.0, 552.0
20.00467726847521, 46.164639850327404

p38{active}

--

e85

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
925.0, 761.5
45.38941436908835, 27.990138860937822

Unknown protein

--

e86

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
237.08066332308022, 116.21638681299686
959.7952853094318, 1409.3597340249455

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1280.0, 227.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
stoichiometry:c4 : 1

m11*m6*0.1

nodelay

--

true

0

false

PMID: 15331118 Activation of T cells is initiated by engagement of the T cell receptor (TCR) with peptide antigen presented by the major histocompatibility complex (MHC) on antigen-presenting cells (APC).

Go back
1025.5, 833.0
20.5, 20.5

p10

p10

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c31 : 1
stoichiometry:c28 : 1

m23*m25*0.1

nodelay

--

true

0

false

PMID:15331118 ZAP-70 subsequently phosphorylates adaptor proteins, such as the linker for activated T cells (LAT), which in turn mobilize other adaptor proteins or enzymes to amplify and to transmit signals downstream through different stages and ultimately lead to the activation of different nuclear transcription factors necessary for cytokine gene transcription.

Go back
862.0, 1041.0
27.0, 27.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c34 : 1

m28*0.1

nodelay

--

true

0

false

PMID:15331118 LAT in turn mobilize other adaptor proteins or enzymes to amplify and to transmit signals downstream through different stages and ultimately lead to the activation of different nuclear transcription factors necessary for cytokine gene transcription.

Go back
864.0, 831.0
23.0, 23.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m86*m26*0.1

nodelay

--

true

0

false

PMID:15331118 LAT in turn mobilize other adaptor proteins or enzymes to amplify and to transmit signals downstream through different stages and ultimately lead to the activation of different nuclear transcription factors necessary for cytokine gene transcription.

Go back
349.0, 20.0
21.0, 21.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m30*m29*0.1

nodelay

--

true

0

false

PMID: 15331118 The binding of LPS to its receptor CD14 at cell surface triggers its association with transmembrane protein toll-like receptor (TLR), mainly TLR2 and TLR4.

Go back
409.0, 20.0
21.0, 21.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m31*m33*0.1

nodelay

--

true

0

false

PMID: 15331118 The binding of LPS to its receptor CD14 at cell surface triggers its association with transmembrane protein toll-like receptor (TLR), mainly TLR2 and TLR4.

Go back
524.0, 20.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c128 : 1

m31*m35*0.1

nodelay

--

true

0

false

PMID: 15331118 The binding of LPS to its receptor CD14 at cell surface triggers its association with transmembrane protein toll-like receptor (TLR), mainly TLR2 and TLR4.

Go back
486.0, 237.0
19.0, 19.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m34*m37*0.1

nodelay

--

true

0

false

PMID: 15331118 MyD88, a cytoplasmic adaptor protein, responds to CD14/TLR stimulation by recruiting IRAK.

Go back
624.0, 211.0
23.0, 23.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m36*m37*0.1

nodelay

--

true

0

false

PMID: 15331118 MyD88, a cytoplasmic adaptor protein, responds to CD14/TLR stimulation by recruiting IRAK.

Go back
742.0, 197.0
20.0, 20.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m32*m39*0.1

nodelay

--

true

0

false

PMID: 15331118 MyD88, a cytoplasmic adaptor protein, responds to CD14/TLR stimulation by recruiting IRAK.

Go back
774.0, 229.0
19.0, 19.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m38*m39*0.1

nodelay

--

true

0

false

PMID: 15331118 MyD88, a cytoplasmic adaptor protein, responds to CD14/TLR stimulation by recruiting IRAK.

Go back
1284.0, 491.0
23.0, 23.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c6 : 1
stoichiometry:c7 : 1

m11*m14*0.1

nodelay

--

true

0

false

PMID: 15331118 Activation of T cells is initiated by engagement of the T cell receptor (TCR) with peptide antigen presented by the major histocompatibility complex (MHC) on antigen-presenting cells (APC) or anti-receptor antibodies.

Go back
906.0, 209.0
19.0, 19.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 15331118 MyD88, a cytoplasmic adaptor protein, responds to CD14/TLR stimulation by recruiting IRAK which leads to IRAK activation.

Go back
1020.0, 227.0
23.0, 23.0

p21

p21

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c62 : 1
stoichiometry:c61 : 1

m43*m42*0.1

nodelay

--

true

0

false

PMID: 15331118 TRAF6 is phosphorylated and recruited to IRAK.

Go back
1113.0, 164.0
21.0, 21.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m44*m42*0.1

nodelay

--

true

0

false

PMID: 15331118 TRAF6 is phosphorylated and recruited to IRAK.

Go back
849.0, 324.0
21.0, 21.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 15331118 MyD88, a cytoplasmic adaptor protein, responds to CD14/TLR stimulation by recruiting IRAK which leads to IRAK activation.

Go back
1020.0, 263.0
23.0, 23.0

p24

p24

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c70 : 1
stoichiometry:c69 : 1

m43*m46*0.1

nodelay

--

true

0

false

--

Go back
1090.0, 293.0
19.0, 19.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m44*m46*0.1

nodelay

--

true

0

false

PMID: 15331118 TRAF6 is phosphorylated and recruited to IRAK.

Go back
670.0, 477.0
19.0, 19.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c78 : 1
stoichiometry:c75 : 1

m48*m71*0.1

nodelay

--

true

0

false

PMID: 15331118 Several tentative molecules have been suggested to relay the signal to IKK complex downstream of TRAF6. NF-¦ÊB-inducing kinase (NIK) is one of these molecules.

Go back
711.0, 370.0
25.0, 25.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c79 : 1
stoichiometry:c77 : 1

m70*m45*0.1

nodelay

--

true

0

false

PMID: 15331118 Several tentative molecules have been suggested to relay the signal to IKK complex downstream of TRAF6. NF-¦ÊB-inducing kinase (NIK) is one of these molecules.

Go back
669.0, 668.0
21.0, 21.0

p28

p28

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c82 : 1
stoichiometry:c81 : 1

m63*m49*0.1

nodelay

--

true

0

false

PMID: 15331118 IKK is a major kinase responsible for the phosphorylation of I¦ÊB.

Go back
681.0, 732.0
29.0, 29.0

p29

p29

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 15331118 Phosphorylated I¦ÊB is eventually degraded, leaving the NF-¦ÊB dimer free and translocate to nucleus

Go back
1089.5, 393.0
20.5, 20.5

p3

p3

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c11 : 1
stoichiometry:c9 : 1

m16*m15*0.1

nodelay

--

true

0

false

PMID: 15331118 Occupancy of the TCR triggers activation of Src family protein tyrosine kinases Fyn and Lck.

Go back
634.0, 873.0
27.0, 27.0

p30

p30

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 15331118 Phosphorylated I¦ÊB is eventually degraded, leaving the NF-¦ÊB dimer free and translocate to nucleus

Go back
577.0, 1072.0
30.0, 30.0

p31

p31

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m67*m68*0.1

nodelay

--

true

0

false

PMID: 15331118 NF-¦ÊB binds to the promoter region of COX-2 gene

Go back
672.0, 419.0
23.0, 23.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c93 : 1
stoichiometry:c92 : 1

m70*m47*0.1

nodelay

--

true

0

false

PMID: 15331118 Several tentative molecules have been suggested to relay the signal to IKK complex downstream of TRAF6. NF-¦ÊB-inducing kinase (NIK) is one of these molecules.

Go back
638.0, 1201.0
27.0, 27.0

p33

p33

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 15331118 NF-¦ÊB binds to the promoter region of COX-2 gene and initiates the transcription.

Go back
411.0, 1267.0
25.0, 25.0

p34

p34

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 15331118 The resulting mRNA of COX-2 encodes synthesis of COX-2 enzyme.

Go back
347.0, 1150.0
25.0, 25.0

p35

p35

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m73*m74*0.1

nodelay

--

true

0

false

PMID: 15331118 COX-2 catalyzes metabolism of AA to PGH2 which is further isomerized to PGE2.

Go back
366.0, 953.0
28.0, 28.0

p36

p36

cso30:i:ME_Isomerization

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 15331118 COX-2 catalyzes metabolism of AA to PGH2 which is further isomerized to PGE2

Go back
293.0, 476.0
30.0, 30.0

p37

p37

cso30:i:ME_Hydrolysis

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c105 : 1
stoichiometry:c104 : 1

m77*m79*0.1

nodelay

--

true

0

false

PMID: 15331118 Ceramide is a sphingolipid second messenger generated from the hydrolysis of membrane sphingomyelin under the action of sphingomyelinase (SMase).

Go back
819.0, 546.0
25.0, 25.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c109 : 1
stoichiometry:c107 : 1

m80*m36*0.1

nodelay

--

true

0

false

PMID: 15331118 Mitogen-activated protein kinase (MAPK) intermediates such as extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinases (JNK), and p38 are involved in LPS- as well as ceramide-induced COX-2 gene expression.

Go back
741.0, 1196.0
21.0, 21.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m81*0.1

nodelay

--

true

0

false

PMID: 15331118 Mitogen-activated protein kinase (MAPK) intermediates such as extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinases (JNK), and p38 are involved in LPS- as well as ceramide-induced COX-2 gene expression.

Go back
1039.0, 574.0
25.0, 25.0

p4

p4

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c15 : 1
stoichiometry:c13 : 1

m18*m13*0.1

nodelay

--

true

0

false

PMID: 15331118 Occupancy of the TCR triggers activation of Src family protein tyrosine kinases Fyn and Lck.

Go back
869.0, 500.0
21.0, 21.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c116 : 1
stoichiometry:c113 : 1

m82*m34*0.1

nodelay

--

true

0

false

PMID: 15331118 Mitogen-activated protein kinase (MAPK) intermediates such as extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinases (JNK), and p38 are involved in LPS- as well as ceramide-induced COX-2 gene expression.

Go back
732.0, 1103.0
23.0, 23.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m83*0.1

nodelay

--

true

0

false

PMID: 15331118 Mitogen-activated protein kinase (MAPK) intermediates such as extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinases (JNK), and p38 are involved in LPS- as well as ceramide-induced COX-2 gene expression.

Go back
419.0, 478.0
25.0, 25.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c120 : 1
stoichiometry:c119 : 1

m84*m34*0.1

nodelay

--

true

0

false

PMID: 15331118 Mitogen-activated protein kinase (MAPK) intermediates such as extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinases (JNK), and p38 are involved in LPS- as well as ceramide-induced COX-2 gene expression.

Go back
677.0, 1072.0
21.0, 21.0

p43

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m85*0.1

nodelay

--

true

0

false

PMID: 15331118 Mitogen-activated protein kinase (MAPK) intermediates such as extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinases (JNK), and p38 are involved in LPS- as well as ceramide-induced COX-2 gene expression.

Go back
712.0, 1027.0
23.0, 23.0

p44

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 15331118 ceramide stimulates by itself and also potentiates LPS-induced PGE2 production and COX-2 expression.

Go back
589.0, 737.0
21.0, 21.0

p28

p45

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c131 : 1
stoichiometry:c130 : 1

m63*m78*0.1

nodelay

--

true

0

false

PMID: 15331118 Ceramide alone was a weak inducer of NF-¦ÊB activation.

Go back
451.0, 479.0
25.0, 25.0

p42

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c133 : 1
stoichiometry:c132 : 1

m84*m36*0.1

nodelay

--

true

0

false

PMID: 15331118 Mitogen-activated protein kinase (MAPK) intermediates such as extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinases (JNK), and p38 are involved in LPS- as well as ceramide-induced COX-2 gene expression.

Go back
771.0, 547.0
25.0, 25.0

p38

p47

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c135 : 1
stoichiometry:c134 : 1

m80*m34*0.1

nodelay

--

true

0

false

PMID: 15331118 Mitogen-activated protein kinase (MAPK) intermediates such as extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinases (JNK), and p38 are involved in LPS- as well as ceramide-induced COX-2 gene expression.

Go back
905.0, 497.0
21.0, 21.0

p40

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c137 : 1
stoichiometry:c136 : 1

m82*m36*0.1

nodelay

--

true

0

false

PMID: 15331118 Mitogen-activated protein kinase (MAPK) intermediates such as extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinases (JNK), and p38 are involved in LPS- as well as ceramide-induced COX-2 gene expression.

Go back
1133.5, 362.0
20.5, 20.5

p3

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c139 : 1
stoichiometry:c138 : 1

m16*m13*0.1

nodelay

--

true

0

false

PMID: 15331118 Occupancy of the TCR triggers activation of Src family protein tyrosine kinases Fyn and Lck.

Go back
1017.0, 460.0
22.0, 22.0

p5

p5

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m20*m17*0.1

nodelay

--

true

0

false

PMID: 15331118 Occupancy of the TCR triggers activation of Src family protein tyrosine kinases Fyn and Lck, which mediate the phosphorylation of immunoreceptor tyrosine-based activation motifs on CD3-¦Æ.

Go back
1017.5, 622.0
20.5, 20.5

p3

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c14 : 1
stoichiometry:c140 : 1

m15*m18*0.1

nodelay

--

true

0

false

PMID: 15331118 Occupancy of the TCR triggers activation of Src family protein tyrosine kinases Fyn and Lck.

Go back
952.0, 463.0
23.0, 23.0

p6

p6

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19*m20*0.1

nodelay

--

true

0

false

PMID: 15331118 Occupancy of the TCR triggers activation of Src family protein tyrosine kinases Fyn and Lck, which mediate the phosphorylation of immunoreceptor tyrosine-based activation motifs on CD3-¦Æ.

Go back
1029.0, 668.0
21.0, 21.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c141 : 1
stoichiometry:c24 : 1

m22*m21*0.1

nodelay

--

true

0

false

PMID: 15331118 Occupancy of the TCR triggers activation of Src family protein tyrosine kinases Fyn and Lck, which mediate the phosphorylation of immunoreceptor tyrosine-based activation motifs on CD3-¦Æ. This leads to the recruitment and activation of ZAP-70.

Go back
1217.0, 256.9207542694089

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1045.7580256148958, 635.9527003248377

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
362.0, 1067.8911513906571

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
380.0, 989.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
350.65685424949237, 937.6568542494924

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
273.0, 444.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
309.0, 506.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
319.8989292741131, 433.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
832.0, 516.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.0, 571.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
904.0, 434.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
641.0, 118.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1106.7626303107336, 421.5078541385816

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
755.13749548724, 653.0

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
695.9405577885492, 1217.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
883.5460518241941, 434.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
880.0, 521.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
750.6524067304601, 753.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
682.2093564318556, 1126.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
518.0, 115.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1063.0, 378.46541608681963

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 428.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 503.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1051.0, 559.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
435.2613347817922, 121.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
797.5876987549067, 507.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
442.0, 595.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
673.6566007563224, 1093.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
327.0, 604.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
676.7237915756482, 1050.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
441.0, 428.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.7839255292249, 789.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
547.0, 39.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.0, 702.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1019.0, 587.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
610.0, 691.2491077284276

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
342.0, 604.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
443.80898753270714, 504.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
472.01707115546486, 118.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
793.0, 572.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
514.0, 121.0

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
885.3011236078253, 518.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
649.0, 118.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1115.376236641263, 383.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1150.7121565968148, 390.5262345561611

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1031.616732229823, 559.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1015.1716000756318, 610.8262546692157

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
970.0, 652.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1071.4191829561219, 534.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1010.0, 430.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
959.3941730389498, 482.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1046.9933444248047, 468.0

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
970.380551483397, 493.6376026758988

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1311.0, 239.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
976.4376015698018, 430.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
950.7449505064465, 486.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1056.40882891103, 690.7882055082407

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1047.0, 689.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
983.0, 843.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1300.0, 250.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1052.240254709472, 856.0059186130931

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1053.6541322323844, 848.3268561986449

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
877.0, 1068.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.0, 843.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
876.0, 854.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
876.0, 924.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
186.0, 32.63601722820888

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
300.0, 43.82082133068498

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1213.435939381538, 250.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.9922778767137, 41.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
368.0, 46.51724137931034

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.0, 49.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
430.0, 39.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
368.0, 38.61688451106533

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.7540371932674, 50.51101052709287

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 121.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.02096365899627, 194.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.0, 93.99352644736227

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
630.0, 118.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1220.0, 420.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
559.0, 189.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
647.0, 95.72682783630002

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
721.0, 105.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
687.0, 214.08644904353986

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.0, 106.01676947949146

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
784.0, 101.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
687.0, 239.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
793.0, 100.31491071063935

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
875.0, 109.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
925.0, 101.48591897643018

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1315.0, 503.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
981.0, 236.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1043.0, 238.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1035.5944732131918, 109.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1092.0, 191.62871174953136

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1082.0, 108.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1130.0, 111.98206517698506

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
867.0304036026449, 109.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
258.0, 335.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
981.0, 247.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1043.0, 259.8

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1219.8896054897032, 514.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
250.0, 276.6008951323524

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1085.0, 255.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.0, 303.29503724892123

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1109.0, 241.51249302884673

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
595.0, 487.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.0, 496.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.0, 383.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 386.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
695.9533106561923, 416.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
742.6275411916054, 87.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1063.0, 403.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
567.0, 679.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 679.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
680.0, 587.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
714.2542459584337, 701.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
710.0, 747.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
693.3897804297072, 761.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
663.7053735814004, 851.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.0, 900.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.9289801172165, 997.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 1087.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1100.0, 414.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.0, 1102.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.0, 392.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
695.0, 411.3616551718397

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.3786268665851, 227.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
646.0, 1168.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.0, 1228.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
443.999905742075, 1279.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
388.99555925583326, 1279.266518641861

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
360.0, 1183.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
309.0, 1120.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back