1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15346645.csml convertedTime:2009.07.01.10:47

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Dual role of oxidized LDL on the NF-kappaB signaling pathway.
Authors Robbesyn F, Salvayre R, Negre-Salvayre A.
Affiliation INSERM U-466, CHU Rangueil, 31403 Toulouse, Cedex 4, France.
Abstract Atherosclerosis is a slowly evolutive age-linked disease of large arteries,characterized by a local lipid deposition associated with a chronic inflammatoryresponse, leading potentially to acute plaque rupture, thrombosis and ischemicheart disease. Atherogenesis is a complex sequence of events associating firstexpression of adhesion molecules, recruitment of mononuclear cells to theendothelium, local activation of leukocytes and inflammation, lipid accumulationand foam cell formation. Low density lipoproteins (LDLs) become atherogenicafter undergoing oxidation by vascular cells, that transform them into highlybioreactive oxidized LDL (oxidized LDLs). Oxidized LDLs are involved in foamcell formation, and trigger proatherogenic events such as overexpression ofadhesion molecules, chemoattractant agents growth factors and cytokines involvedin the inflammatory process, cell proliferation and apoptosis. Moreover, thistoxic effect of oxidized LDLs plays probably a role in plaque erosion/ruptureand subsequent atherothrombosis. Several biological effects of oxidized LDLs aremediated through changes in the activity of transcription factors andsubsequently in gene expression. Oxidized LDLs exert a biphasic effect on theredox-sensitive transcription factor NF-kappaB, which can be activated therebyup-regulating proinflammatory gene expression, such as adhesion molecules,tissue factor, scavenger receptor LOX-1. On the other hand, higherconcentrations of oxidized LDLs may inhibit NF-kappaB activation triggered byinflammatory agents such as LPS, and may thereby exert an immunosuppressiveeffect. This review is an attempt to clarify the mechanism by which oxidizedLDLs may up- or down-regulate NF-kappaB, the role of NF-kappaB activation (orinhibition), and the consequences of the oxidized LDLs-mediated NF-kappaBdysregulation and their potential involvement in atherosclerosis.
PMID 15346645
Model Abstract

Entity

G010329:TNF-alpha G010334:SELE G010389:IL-1beta G010430:VCAM-1 G010432:p53 G010462:FASN G010815:MCP1 MO000000030:PI3K MO000000047:MEKK1 MO000000048:AKT MO000000104:PKC MO000000203:NIK MO000000233:IkappaB-alpha MO000009092:MEKK2 MO000009093:MEKK3 MO000016599:IKK-gamma MO000016894:MAPK MO000019331:TBK1 MO000019395:TLRs MO000033291:IKK-alpha:IKK-beta MO000042409:LPS e1: e10:VCAM1:NF-kappaB e100:PDGJ2:PPARG e101:LOX1 e102:FasL e103:c-myc e104:TF e105:AT1 e106:AT1 e11:TBK1 e12:MEKK1{active} e13:MEKK3{active} e14:MEKK2 e15:AKT{active} e16:(IKK-gamma)2 e17:IKK-alpha:IKK-beta:(IKK-gamma)2 e18:MEKK3:IKK-alpha:IKK-beta:(IKK-gamma)2 e19:MEKK3:IKK-alpha:IKK-beta{p}:(IKK-gamma)2 e2: e20:NIK:IKK-alpha:IKK-beta:(IKK-gamma)2 e21:NIK:IKK-alpha:IKK-beta{p}:(IKK-gamma)2 e22:PKC{active}:IKK-alpha:IKK-beta:(IKK-gamma)2 e23:PKC{active}:IKK-alpha:IKK-beta{p}:(IKK-gamma)2 e24:MEKK1:IKK-alpha:IKK-beta:(IKK-gamma)2 e25:MEKK1:IKK-alpha:IKK-beta:(IKK-gamma)2 e26:AKT:IKK-alpha:IKK-beta:(IKK-gamma)2 e27:AKT:IKKA:IKKB{p}:(IKKG)2 e28:MEKK2:IKK-alpha:IKK-beta:(IKK-gamma)2 e29:Mekk2:IKK-alpha:IKK-beta{p}:(IKK-gamma)2 e3: e30:TBK1:IKKA:IKKb{p}:(IKKG)2 e31:TBK1:IKKA:IKKB{p}:(IKKG)2 e32:NF-kappaB:I-kappaB{alpha} e33:NF-kappaB:I-kappaB{alpha}{p} e34:NF-kappaB:I-kappaB{alpha}{p}{ub} e35:protein remnants e36:NF-kappaB{active} e37:NF-kappaB e38:TNF-alpha e39:TNF-alpha:NF-kappaB e4: e40:IL-1 e41:IL-1:NF-kappaB e42:IL-1 e43:ICAM1 e44:ICAM1:NFkapapB e45:ICAM1 e46:Eselectin e47:Eselectin:NFkappaB e48:BCL-xL e49:BCL-xL:NFkappaB e5:PKC{active} e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:NIK{active} e60: e61: e62: e63:BCL-xL e64:c-IAPs e65:NF-kappaB:c-IAPs e66:c-IAPs e67:IkappaB-alpha e68:IkappaB-alpha e69:NF-kappaB:I-kappaB{alpha} e7:VCAM1 e70:UV e71:NF-kappaB e72:PI3K:NFkappaB:IkappaBalpha e73:PI3K:IKappaBalpha e74:H2O2 e75:13-HPODE e76:NAC e77:calphostin C e78:Lyso-PC e79:Tyrosine kinase e8: e80:Tyrosine kinase {active} e81:MAPK e82:HNE e83:oxidised LDL e84:sphingosine-1-phosphate e85:LOX1 e86:oxidized LDL:LOX1 e87:ROS e88:LPS:TLRs e89:PAF-receptor e9: e90:phtohaemagglutinin e91:IL-2R e92:PPAR-gamma e93:9-HODE e94:9-HODE:PPARG e95:13-HODE e96:13-HODE:PPARG e97:HETE e98:HETE:PPARG e99:PDGJ2

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91
Model Detail
1035.0, 1323.0
34.0, 34.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p35 p71

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
877.0, 1519.0
41.0, 41.0

SELE

--

G010334

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p43

--

true true true true

csml-variable:Double

m93313

10

false

infinite

0

unit false false false
TRANSFACG010334

--

Go back
1135.0, 1247.0
34.0, 34.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p72

--

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
1091.0, 1451.0
42.0, 42.0

VCAM-1

--

G010430

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p41 p59

--

true true true true

csml-variable:Double

m93402

10

false

infinite

0

unit false false false
TRANSFACG010430

--

Go back
1198.0, 1274.0
36.0, 36.0

p53

--

G010432

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p85

--

true true true true

csml-variable:Double

m93404

10

false

infinite

0

unit false false false
TRANSFACG010432

--

Go back
824.0, 1056.0
32.0, 32.0

FASN

--

G010462

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p84

--

true true true true

csml-variable:Double

m93432

10

false

infinite

0

unit false false false
TRANSFACG010462

--

Go back
704.0, 1148.0
40.0, 40.0

MCP1

--

G010815

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p61

--

true true true true

csml-variable:Double

m93710

10

false

infinite

0

unit false false false
TRANSFACG010815

--

Go back
1269.0, 637.0
38.0, 38.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1012.0, 202.0
28.0, 28.0

MEKK1

--

MO000000047

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000047

--

Go back
1099.0, 201.0
30.0, 30.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
919.0, 197.0
38.0, 38.0

PKC

--

MO000000104

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p91

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
762.0, 200.0
32.0, 32.0

NIK

--

MO000000203

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m174

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
1236.0, 1576.0
31.0, 31.0

IkappaB-alpha

--

MO000000233

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

p50

true true true true

csml-variable:Double

m199

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
543.0, 209.0
29.0, 29.0

MEKK2

--

MO000009092

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m1115

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000009092

--

Go back
605.0, 255.0
26.0, 26.0

MEKK3

--

MO000009093

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m1116

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000009093

--

Go back
1273.0, 297.0
29.0, 29.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
416.0, 104.0
40.0, 40.0

MAPK

--

MO000016894

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p63

true true true true

csml-variable:Double

m1812

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
675.0, 205.0
30.0, 30.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1411.0, 771.0
42.0, 42.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p69

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
1192.0, 398.0
36.0, 36.0

IKK-alpha:IKK-beta

--

MO000033291

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m11981

10

false

infinite

0

unit false false false
TRANSPATHMO000033291

--

Go back
1593.0, 773.0
38.0, 38.0

LPS

--

MO000042409

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p69

true true true true

csml-variable:Double

m157177

10

false

infinite

0

unit false false false
TRANSPATHMO000042409

--

Go back
219.1786744250983, 9.157188494590741
1265.8529092597255, 1838.0184242451185

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
1076.0, 1311.5
60.0, 17.0

VCAM1:NF-kappaB

--

e10

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p40

p41

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
1256.5, 1486.4172330629247
22.001096250822187, 42.5827669370752

PDGJ2:PPARG

--

e100

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p81

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1053.0, 1093.3771626297578
53.667820069204154, 28.622837370242216

LOX1

--

e101

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p82 p90

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
873.0, 1039.3356401384085
46.24567474048443, 24.664359861591695

FasL

--

e102

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p83

--

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
1173.0, 1403.4186851211073
46.089965397923876, 24.581314878892734

c-myc

--

e103

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p86

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
983.0, 1530.8166089965398
50.96885813148789, 27.18339100346021

TF

--

e104

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p87

--

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
838.0, 1584.0
60.0, 32.0

AT1

--

e105

cso30:c:mRNA

cso30:i:CC_Cell_WithoutCellWall_

--

p88

p89

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
1071.0, 1675.1926947071845
42.66049506943047, 26.307305292815457

AT1

--

e106

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

p89

p90

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
679.0, 329.0
30.0, 30.0

TBK1

--

e11

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

p22

true true true true

csml-variable:Double

m11

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1012.0, 330.0
28.0, 28.0

MEKK1{active}

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

p16

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000047

--

Go back
605.0, 391.0
26.0, 26.0

MEKK3{active}

--

e13

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p10

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000009093

--

Go back
543.0, 349.0
29.0, 29.0

MEKK2

--

e14

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4

p20

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000009092

--

Go back
1099.0, 309.0
30.0, 30.0

AKT{active}

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

p18

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
1252.0, 478.0
36.0, 36.0

(IKK-gamma)2

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p8

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
TRANSPATHMO000033291

--

Go back
1077.5, 425.3255643237293
32.73334556799413, 45.67443567627089

IKK-alpha:IKK-beta:(IKK-gamma)2

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p10 p12 p14 p16 p18 p20 p22

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1008.0, 561.4117647058823
27.352941176470587, 45.588235294117645

MEKK3:IKK-alpha:IKK-beta:(IKK-gamma)2

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p11

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1009.0, 714.029411764706
26.823529411764707, 44.70588235294119

MEKK3:IKK-alpha:IKK-beta{p}:(IKK-gamma)2

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p28

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
219.1786744250983, 9.157188494590741
1265.8529092597255, 1838.0184242451185

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
911.0, 530.8529411764706
30.08823529411764, 50.14705882352941

NIK:IKK-alpha:IKK-beta:(IKK-gamma)2

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p13

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
915.0, 655.1470588235295
29.911764705882348, 49.852941176470594

NIK:IKK-alpha:IKK-beta{p}:(IKK-gamma)2

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p27

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1098.0, 537.5
31.5, 52.5

PKC{active}:IKK-alpha:IKK-beta:(IKK-gamma)2

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p15

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1099.0, 678.8235294117648
30.705882352941167, 51.176470588235304

PKC{active}:IKK-alpha:IKK-beta{p}:(IKK-gamma)2

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p29

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1180.0, 535.9117647058824
28.85294117647058, 48.08823529411765

MEKK1:IKK-alpha:IKK-beta:(IKK-gamma)2

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p17

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1179.0, 666.8529411764706
30.08823529411765, 50.14705882352941

MEKK1:IKK-alpha:IKK-beta:(IKK-gamma)2

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p30

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
847.0, 458.2647058823529
30.441176470588236, 50.735294117647065

AKT:IKK-alpha:IKK-beta:(IKK-gamma)2

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
847.0, 599.4411764705883
29.735294117647058, 49.55882352941177

AKT:IKKA:IKKB{p}:(IKKG)2

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p26

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
543.0, 507.47058823529426
29.117647058823522, 48.5294117647059

MEKK2:IKK-alpha:IKK-beta:(IKK-gamma)2

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p21

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
544.0, 631.9117647058824
28.85294117647058, 48.08823529411765

Mekk2:IKK-alpha:IKK-beta{p}:(IKK-gamma)2

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p24

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
244.49573261029292, 34.474246679785274
1215.2187928893366, 1787.3843078747327

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
680.0, 474.0
36.0, 60.0

TBK1:IKKA:IKKb{p}:(IKKG)2

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p23

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
683.0, 627.0294117647059
29.38235294117647, 48.97058823529412

TBK1:IKKA:IKKB{p}:(IKKG)2

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p25

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
492.0, 823.9944751381216
44.10497237569061, 49.00552486187846

NF-kappaB:I-kappaB{alpha}

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

p24 p25 p26 p27 p28 p29 p30 p76

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1036.0, 829.1381215469613
40.37569060773481, 44.86187845303868

NF-kappaB:I-kappaB{alpha}{p}

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24 p25 p26 p27 p28 p29 p30 p76

p31 p54

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1226.0, 830.1878453038674
39.43093922651934, 43.812154696132595

NF-kappaB:I-kappaB{alpha}{p}{ub}

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

p77

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1228.0, 1022.9035037334866
36.30672027570362, 35.0964962665135

protein remnants

--

e35

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p77

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1063.0, 999.4599999999999
34.71999999999999, 26.040000000000003

NF-kappaB{active}

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

p53 p55 p56 p57 p58 p64 p66 p70 p74

p33

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
942.0, 1167.22
35.04, 26.279999999999998

NF-kappaB

--

e37

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p33

p34 p36 p38 p40 p42 p44 p46 p48 p51 p71 p72 p73 p75 p82 p83 p84 p85 p86 p88

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
808.0, 1233.5
60.0, 13.0

TNF-alpha

--

e38

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p34

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
956.0, 1231.5
60.0, 17.0

TNF-alpha:NF-kappaB

--

e39

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p34

p35

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
291.3322902529027, 78.77909850387545
1121.545677604119, 1698.7746042265494

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
780.0, 1173.5
60.0, 13.0

IL-1

--

e40

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p36

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
721.0, 1228.0245564412446
58.148624325019284, 16.475443558755465

IL-1:NF-kappaB

--

e41

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p36

p37

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
719.0, 1361.3771626297578
53.667820069204154, 28.622837370242216

IL-1

--

e42

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p37

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
776.0, 1285.5
60.0, 13.0

ICAM1

--

e43

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p38

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
949.0, 1284.0245564412446
58.148624325019284, 16.475443558755465

ICAM1:NFkapapB

--

e44

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p38

p39

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
954.0, 1409.9584775086505
52.57785467128028, 28.041522491349482

ICAM1

--

e45

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p39 p60

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
788.0, 1329.5
60.0, 13.0

Eselectin

--

e46

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p42

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
868.0, 1395.5
60.0, 17.0

Eselectin:NFkappaB

--

e47

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p42

p43

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
704.0, 1429.5
60.0, 13.0

BCL-xL

--

e48

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p44

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
744.0, 1491.5
60.0, 17.0

BCL-xL:NFkappaB

--

e49

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p44

p45

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
919.0, 321.0
38.0, 38.0

PKC{active}

--

e5

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1 p91

p14

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
553.8208599561117, 1013.5248741176435
684.6738887786136, 620.9239922442929

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
627.7707399359244, 1028.2398700523331
400.3493502355395, 601.799023283996

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
562.7458454709166, 1021.8123606671045
666.8239177490038, 604.3490191453687

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
564.0208434016031, 1023.0873585977924
664.2739218876304, 601.799023283996

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
553.8208599561117, 1013.5248741176435
684.6738887786136, 620.9239922442929

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
553.8208599561117, 1013.5248741176435
684.6738887786136, 620.9239922442929

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
564.0208434016031, 1023.0873585977924
664.2739218876304, 601.799023283996

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
1053.620048785193, 1268.5244602549299
42.77466262741659, 38.722326167977215

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
941.4202308847867, 1447.0241705510293
121.12480341521095, 109.64982203903327

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
553.8208599561117, 1013.5248741176435
684.6738887786136, 620.9239922442929

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
762.0, 344.0
32.0, 32.0

NIK{active}

--

e6

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p12

true true true true

csml-variable:Double

m6

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
715.1946431464246, 1289.4583655338206
21.68261603501562, 10.439778090933476

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
714.4705992226015, 1258.3244768094382
74.21450219184221, 133.58610394531607

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
745.6044879469836, 1345.2097476681827
11.584702781165612, 11.584702781165635

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
767.0, 1570.840830449827
49.048442906574394, 26.15916955017301

BCL-xL

--

e63

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p45

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
640.0, 1273.5
60.0, 13.0

c-IAPs

--

e64

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p46

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
620.0, 1375.5
60.0, 17.0

NF-kappaB:c-IAPs

--

e65

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p46

p47

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
682.0, 1452.0
60.0, 32.0

c-IAPs

--

e66

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p47

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
916.0, 1576.0
60.0, 32.0

IkappaB-alpha

--

e67

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p48

p49

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1132.0, 1420.0
31.0, 31.0

IkappaB-alpha

--

e68

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

p51

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
999.5, 1465.8473587735377
36.05799033494418, 44.15264122646225

NF-kappaB:I-kappaB{alpha}

--

e69

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p51

p52

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1046.0, 1185.5
60.0, 13.0

VCAM1

--

e7

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p40

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false false false

--

Go back
120.5, 991.3429697766098
38.62417871222077, 40.65703022339028

UV

--

e70

cso30:c:EntityBiologicalEnvironment

cso30:i:CC_Cell_WithoutCellWall_

--

--

p53

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
997.0, 878.06
37.92, 28.44

NF-kappaB

--

e71

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p53 p56 p57 p58 p64 p66 p70 p74

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1303.5, 741.4576986603048
32.63864929344834, 45.542301339695356

PI3K:NFkappaB:IkappaBalpha

--

e72

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p54

p55

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1300.0, 1085.9723756906078
40.52486187845304, 45.027624309392266

PI3K:IKappaBalpha

--

e73

cso30:c:SmallMolecule

cso30:i:CC_Cell_WithoutCellWall_

--

p55

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1120.0, 1041.235294117647
47.94117647058824, 28.764705882352942

H2O2

--

e74

cso30:c:SmallMolecule

cso30:i:CC_Cytoplasm

--

--

p56

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
130.0, 1075.0
60.0, 34.0

13-HPODE

--

e75

cso30:c:SmallMolecule

cso30:i:CC_Cytoplasm

--

--

p41 p57

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
414.0, 1315.0
60.0, 34.0

NAC

--

e76

cso30:c:SmallMolecule

cso30:i:CC_Cell_WithoutCellWall_

--

--

p40 p41

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
386.0, 1427.0
60.0, 34.0

calphostin C

--

e77

cso30:c:SmallMolecule

cso30:i:CC_Cell_WithoutCellWall_

--

--

p40 p41

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
94.0, 259.0
60.0, 34.0

Lyso-PC

--

e78

cso30:c:SmallMolecule

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p1 p58 p59 p60 p61 p62 p70 p87

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
361.0, 283.6361085126286
21.391019644527596, 49.36389148737138

Tyrosine kinase

--

e79

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p62

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
252.2099814892471, 96.26324737504228
1151.409839765435, 1671.8470873394122

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
398.0, 424.2357343311506
20.697848456501404, 47.76426566884939

Tyrosine kinase {active}

--

e80

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p62

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
416.0, 212.0
40.0, 40.0

MAPK

--

e81

cso30:c:Protein

cso30:i:CC_CellComponent

--

p63

--

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
102.0, 159.0
60.0, 34.0

HNE

--

e82

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p63 p76 p77

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
137.5, 890.0
37.0, 60.0

oxidised LDL

--

e83

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p2 p3 p4 p5 p6 p7 p33 p65 p67 p70 p71 p72 p73 p74 p75 p87 p91

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
334.0, 739.0
60.0, 34.0

sphingosine-1-phosphate

--

e84

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p65

p66

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
247.0, 819.9399999999999
42.08, 31.560000000000002

LOX1

--

e85

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p67

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
247.0, 696.0939226519337
42.215469613259664, 46.906077348066304

oxidized LDL:LOX1

--

e86

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p67

p68

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
346.5, 597.9966106482135
35.403332862590034, 36.00338935178647

ROS

--

e87

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p68

p64

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
1424.5, 866.0
31.0, 60.0

LPS:TLRs

--

e88

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p69

p70 p71 p72 p73 p76 p77 p87

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
590.0, 1320.0
60.0, 32.0

PAF-receptor

--

e89

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p73

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
310.76619123616274, 90.72329796069585
857.6308025887296, 1234.584948679698

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
106.0, 1233.5
60.0, 37.0

phtohaemagglutinin

--

e90

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p74 p75

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
705.0, 1551.5017301038065
45.93425605536332, 24.498269896193772

IL-2R

--

e91

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p75

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1236.5, 1180.9349736379615
30.592267135325134, 47.06502636203867

PPAR-gamma

--

e92

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p78 p79 p80 p81

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1346.0, 1055.0
60.0, 34.0

9-HODE

--

e93

cso30:c:SmallMolecule

cso30:i:CC_Cell_WithoutCellWall_

--

--

p78

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
1267.5, 1303.773953080465
25.43345757509318, 49.22604691953519

9-HODE:PPARG

--

e94

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p78

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1334.0, 1281.5752733389404
51.92598822539949, 29.42472666105971

13-HODE

--

e95

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p79

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
1307.5, 1348.5367244025433
24.52269239201929, 47.46327559745669

13-HODE:PPARG

--

e96

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p79

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1241.0, 1104.8460891505465
53.212783851976454, 30.153910849453325

HETE

--

e97

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p80

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
1290.5, 1409.5904406928305
27.07827230870423, 52.40955930716948

HETE:PPARG

--

e98

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p80

--

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
1338.0, 1519.7645079899075
44.5332211942809, 25.23549201009251

PDGJ2

--

e99

cso30:c:SmallMolecule

cso30:i:CC_Cell_WithoutCellWall_

--

--

p81

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
926.0, 272.0
24.0, 24.0

p1

p1

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000104 e78

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c149 : 1
stoichiometry:c2 : 1

m92*m81*0.1

nodelay

--

true

0

false

PMID: 15346645, 9555862, 1381720, 8622597, 9084506 Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.

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1007.0, 505.0
21.0, 21.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 e17

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c24 : 1

m13*m17*0.1

nodelay

--

true

0

false

PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.

Go back
1010.0, 644.0
23.0, 23.0

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.

Go back
864.0, 350.0
19.0, 19.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 e17

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m6*m17*0.1

nodelay

--

true

0

false

PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.

Go back
920.0, 602.0
19.0, 19.0

p13

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.

Go back
971.0, 477.0
21.0, 21.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 e17

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m5*m17*0.1

nodelay

--

true

0

false

PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.

Go back
1105.0, 626.5
18.5, 18.5

p15

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.

Go back
1030.0, 388.0
23.0, 23.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 e17

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m12*m17*0.1

nodelay

--

true

0

false

PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.

Go back
1182.0, 620.0
23.0, 23.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.

Go back
1167.0, 345.0
21.0, 21.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 e15

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m17*m15*0.1

nodelay

--

true

0

false

PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.

Go back
850.0, 547.5
24.5, 24.5

p19

p19

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.

Go back
768.0, 276.0
23.0, 23.0

p2

p2

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000203 e83

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c250 : 1
stoichiometry:c4 : 1

m174*m86*0.1

nodelay

--

true

0

false

PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.

Go back
546.0, 436.0
23.0, 23.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 e17

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m14*m17*0.1

nodelay

--

true

0

false

PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.

Go back
546.0, 584.0
23.0, 23.0

p21

p21

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.

Go back
689.0, 402.5
18.5, 18.5

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 e17

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m11*m17*0.1

nodelay

--

true

0

false

PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.

Go back
686.0, 560.0
23.0, 23.0

p23

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.

Go back
758.0, 837.5
20.5, 20.5

p24

p24

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

e32 e29

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1

m32*m29*0.1

nodelay

--

true

0

false

PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB. PMID: 15346645 Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).

Go back
797.0, 886.5
18.5, 18.5

p25

p25

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e32 e31

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c59 : 1

m32*m31*0.1

nodelay

--

true

0

false

Go back
737.0, 926.5
18.5, 18.5

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e32 e27

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c63 : 1
stoichiometry:c62 : 1

m32*m27*0.1

nodelay

--

true

0

false

PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB. PMID: 15346645 Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).

Go back
826.0, 796.0
23.0, 23.0

p27

p27

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e32 e21

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c65 : 1

m32*m21*0.1

nodelay

--

true

0

false

PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB. PMID: 15346645 Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).

Go back
794.0, 926.5
19.5, 19.5

p28

p28

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e32 e19

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c69 : 1
stoichiometry:c68 : 1

m32*m19*0.1

nodelay

--

true

0

false

PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB. PMID: 15346645 Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).

Go back
766.0, 966.0
20.0, 20.0

p29

p29

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e32 e23

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c72 : 1
stoichiometry:c71 : 1

m32*m23*0.1

nodelay

--

true

0

false

PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB. PMID: 15346645 Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).

Go back
679.0, 275.0
26.0, 26.0

p3

p3

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e83

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c249 : 1
stoichiometry:c6 : 1

m3902*m86*0.1

nodelay

--

true

0

false

PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.

Go back
766.0, 760.0
23.0, 23.0

p30

p30

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e32 e25

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c74 : 1

m32*m25*0.1

nodelay

--

true

0

false

PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB. PMID: 15346645 Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).

Go back
1116.0, 838.0
27.0, 27.0

p31

p31

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 15346645 This leads to IkB ubiquitination and subsequent degradation by the 26S proteasome.

Go back
939.0, 983.0
25.0, 25.0

p33

p33

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e36 e83

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c168 : 1
stoichiometry:c82 : 1

m36*m86*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL)immunoreceptors. PMID: 15346645, 12586748 oxLDL-mediated NF-kB nuclear translocation.

Go back
892.0, 1220.0
23.0, 23.0

p34

p34

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e37 e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m37*m38*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.

Go back
1013.0, 1263.0
25.0, 25.0

p35

p35

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e39

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.

Go back
867.0, 1171.0
25.0, 25.0

p36

p36

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e40 e37

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m40*m37*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.

Go back
732.0, 1280.0
23.0, 23.0

p37

p37

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c91 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.

Go back
872.0, 1276.0
24.0, 24.0

p38

p38

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e43 e37

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m43*m37*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.

Go back
969.0, 1333.0
21.0, 21.0

p39

p39

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.

Go back
548.0, 276.0
23.0, 23.0

p4

p4

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000009092 e83

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c247 : 1
stoichiometry:c8 : 1

m1115*m86*0.1

nodelay

--

true

0

false

PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.

Go back
1100.0, 1244.0
23.0, 23.0

p40

p40

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e37 e7 e76 e77

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c100 : 1

m37*m7*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors. PMID: 15346645, 11557664 This effect is mediated by oxidative stress and PKC as assessed bythe inhibition of NF-kB DNA binding and transcriptionof VCAM-1 gene by the antioxidant NAC and calphostin C.

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1092.0, 1372.0
23.0, 23.0

p41

p41

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e10 e75 e76 e77

G010430

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c144 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c102 : 1

m10*m78*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.

Go back
877.0, 1333.0
21.0, 21.0

p42

p42

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e46 e37

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m48*m37*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.

Go back
887.0, 1453.0
21.0, 21.0

p43

p43

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e47

G010334

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.

Go back
803.0, 1425.0
21.0, 21.0

p44

p44

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e48 e37

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c109 : 1

m63*m37*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.

Go back
773.0, 1533.0
21.0, 21.0

p45

p45

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e49

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.

Go back
659.0, 1313.0
21.0, 21.0

p46

p46

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e64 e37

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c113 : 1

m66*m37*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.

Go back
639.0, 1433.0
21.0, 21.0

p47

p47

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.

Go back
926.0, 1506.0
19.0, 19.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e37

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 15346645 A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB. The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.

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1200.0, 1582.0
19.0, 19.0

p49

p49

cso30:i:ME_Translation

cso30:i:CC_Cell_WithoutCellWall_

--

e67

MO000000233

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 15346645 A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB. The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.

Go back
609.0, 325.0
21.0, 21.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000009093 e83

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c248 : 1
stoichiometry:c10 : 1

m1116*m86*0.1

nodelay

--

true

0

false

PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.

Go back
1196.0, 1516.0
23.0, 23.0

p50

p50

cso30:i:ME_Translocation

cso30:i:CC_Cell_WithoutCellWall_

--

MO000000233

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m199*0.1

nodelay

--

true

0

false

PMID: 15346645 A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB. The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.

Go back
1042.0, 1404.0
23.0, 23.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e37 e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m37*m70*0.1

nodelay

--

true

0

false

PMID: 15346645 A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB. The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.

Go back
501.0, 1475.0
26.0, 26.0

p52

p52

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

e69

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 15346645 A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB. The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.

Go back
879.0, 999.0
25.0, 25.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e71 e70

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c131 : 1
stoichiometry:c130 : 1

m73*m72*0.1

nodelay

--

true

0

false

PMID: 15346645 UV radiation-induced NF-kB activation does not involve IkBa phosphorylation

Go back
1178.0, 750.0
19.0, 19.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e33 MO000000030

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m33*m74*0.1

nodelay

--

true

0

false

PMID: 15346645, 10488062, 10373503, 10723801 phosphorylation of IkBa at tyrosine 42, that may bind the SH2 domain ofPI3-kinase which pulls it away from NF-kB.

Go back
1308.0, 1000.0
23.0, 23.0

p55

p55

cso30:i:ME_Dissociation

cso30:i:CC_Cell_WithoutCellWall_

--

e72

e36 e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 15346645, 10488062, 10373503, 10723801 phosphorylation of IkBa at tyrosine 42, that may bind the SH2 domain ofPI3-kinase which pulls it away from NF-kB.

Go back
1013.0, 953.0
21.0, 21.0

p56

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e71 e74

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c140 : 1
stoichiometry:c139 : 1

m73*m77*0.1

nodelay

--

true

0

false

PMID: 15346645 NF-kB is a redox-sensitive transcription factorwhich is activated by intracellular reactive oxygen species (ROS), such as H2O2.

Go back
1056.0, 948.0
23.0, 23.0

p57

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e71 e75

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c143 : 1
stoichiometry:c142 : 1

m73*m78*0.1

nodelay

--

true

0

false

PMID: 15346645, 11557664 13-HPODE (13-hydroperoxyoctadecadienoic acid) induces NF-kB activation and subsequent overexpression of the vascular cell adhesion molecule-1 (VCAM-1) in porcine vascular SMCs.

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978.0, 950.0
19.0, 19.0

p58

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e71 e78

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1

m73*m81*0.1

nodelay

--

true

0

false

PMID: 15346645, 9555862, 1381720, 8622597, 9084506 Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.

Go back
1144.0, 1344.0
23.0, 23.0

p59

p59

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e78

G010430

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c153 : 1

m81*0.1

nodelay

--

true

0

false

PMID: 15346645, 9555862, 1381720, 8622597, 9084506 Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.

Go back
1014.0, 274.0
19.0, 19.0

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000047 e83

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c251 : 1
stoichiometry:c12 : 1

m44*m86*0.1

nodelay

--

true

0

false

PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.

Go back
919.0, 1335.0
25.0, 25.0

p60

p60

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e78

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c155 : 1

m81*0.1

nodelay

--

true

0

false

PMID: 15346645, 9555862, 1381720, 8622597, 9084506 Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.

Go back
783.0, 1095.0
25.0, 25.0

p61

p61

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e78

G010815

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c157 : 1

m81*0.1

nodelay

--

true

0

false

PMID: 15346645, 9555862, 1381720, 8622597, 9084506 Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.

Go back
348.0, 372.0
23.0, 23.0

p62

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e79 e78

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c161 : 1
stoichiometry:c160 : 1

m82*m81*0.1

nodelay

--

true

0

false

PMID: 15346645, 9555862, 1381720, 8622597, 9084506 Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.

Go back
376.0, 164.0
23.0, 23.0

p63

p63

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

MO000016894 e82

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c164 : 1
stoichiometry:c163 : 1

m1812*m85*0.1

nodelay

--

true

0

false

PMID: 15346645 Low HNE concentration induces MAPK activation.

Go back
1084.0, 936.0
23.0, 23.0

p64

p64

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e71 e87

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c167 : 1
stoichiometry:c166 : 1

m73*m90*0.1

nodelay

--

true

0

false

PMID: 15346645, 8876974 Moderate concentrations of oxidized LDLs trigger a rapid and dose-dependent activation of NF-kB. PMID: 15346645 ROS are generated by a DPI-sensitive oxidase system activated through signaling triggered by binding ofoxidized LDLs to LOX-1 (lectin-like ox-LDL receptor-1) in endothelial cells.

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351.0, 843.0
25.0, 25.0

p65

p65

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

e83

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 15346645, 8657285 Another survival mechanism that regulates cell death and proliferation induced by oxidized LDLs is the generation of bioactive sphingolipid metabolites, for instance sphingosine-1-phosphate (S1-P).

Go back
1116.0, 924.0
23.0, 23.0

p66

p66

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e71 e84

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c173 : 1
stoichiometry:c172 : 1

m73*m87*0.1

nodelay

--

true

0

false

PMID: 15346645, 10567432, 9826677 S1-P is involved in NF-kB activation mediated by inflammatory cytokines

Go back
172.0, 824.0
23.0, 23.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e83 e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c175 : 1
stoichiometry:c176 : 1

m86*m88*0.1

nodelay

--

true

0

false

PMID: 15346645 ROS are generated by a DPI-sensitive oxidase system activated through signaling triggered by binding ofoxidized LDLs to LOX-1 (lectin-like ox-LDL receptor-1) in endothelial cells.

Go back
353.0, 673.0
30.0, 30.0

p68

p68

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c178 : 1

m89*0.1

nodelay

--

true

0

false

PMID: 15346645 ROS are generated by a DPI-sensitive oxidase system activated through signaling triggered by binding ofoxidized LDLs to LOX-1 (lectin-like ox-LDL receptor-1) in endothelial cells.

Go back
1530.0, 782.0
19.0, 19.0

p69

p69

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042409 MO000019395

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c181 : 1

m157177*m3962*0.1

nodelay

--

true

0

false

PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995 oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages.

Go back
1100.0, 259.5
24.5, 24.5

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000048 e83

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c252 : 1
stoichiometry:c14 : 1

m45*m86*0.1

nodelay

--

true

0

false

PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.

Go back
1155.0, 895.0
25.0, 25.0

p70

p70

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e71 e88 e83 e78

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c184 : 1
stoichiometry:c188 : 1
stoichiometry:c240 : 1
stoichiometry:c183 : 1

m73*m91*0.1

nodelay

--

true

0

false

PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995 oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages. PMID: 15346645, 9888865 oxidized LDLs significantly enhanced TF expression induced by LPS in human monocytes, whereas other reports have shown that lysoPC induce a decrease in both NFkB activation and TF expression induced by LPS.

Go back
1046.0, 1134.0
19.0, 19.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37 e88 e83

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c187 : 1
stoichiometry:c189 : 1
stoichiometry:c186 : 1

m37*m91*0.1

nodelay

--

true

0

false

PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995 oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages.

Go back
1107.0, 1163.0
25.0, 25.0

p72

p72

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37 e88 e83

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c192 : 1
stoichiometry:c193 : 1
stoichiometry:c190 : 1

m37*m91*0.1

nodelay

--

true

0

false

PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995 oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages.

Go back
652.0, 1208.0
23.0, 23.0

p73

p73

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37 e88 e83

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c194 : 1

m37*m91*0.1

nodelay

--

true

0

false

PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995 oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages.

Go back
901.0, 945.0
21.0, 21.0

p74

p74

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e71 e90 e83

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c200 : 1
stoichiometry:c201 : 1
stoichiometry:c199 : 1

m73*m94*0.1

nodelay

--

true

0

false

PMID: 15346645, 9882624 phytohaemagglutinin (PHA)-induced NF-kB activation and subsequent IL-2 receptor expression in human T-lymphocytes.

Go back
671.0, 1499.0
25.0, 25.0

p75

p75

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e37 e90 e83

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1
stoichiometry:c202 : 1

m37*m94*0.1

nodelay

--

true

0

false

PMID: 15346645, 9882624 phytohaemagglutinin (PHA)-induced NF-kB activation and subsequent IL-2 receptor expression in human T-lymphocytes.

Go back
940.0, 744.0
23.0, 23.0

p76

p76

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e32 e88 e82

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c208 : 1
stoichiometry:c209 : 1
stoichiometry:c207 : 1

m32*m91*0.1

nodelay

--

true

0

false

PMID: 15346645, 10206970 HNE prevents the LPS-induced IkBa phosphorylation in THP-1 monocytic cells.

Go back
1263.0, 923.0
25.0, 25.0

p77

p77

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cell_WithoutCellWall_

--

e34 e88 e82

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c212 : 1
stoichiometry:c213 : 1
stoichiometry:c211 : 1

m34*m91*0.1

nodelay

--

true

0

false

PMID: 15346645, 10698969, 10446139 HNE (like oxidized LDLS) is also able to inhibit the proteasome activity and subsequent proteolysis of IkBa, possibly through a modification of proteasome proteins by 4-HNE.

Go back
1345.0, 1192.5
22.5, 22.5

p78

p78

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e92 e93

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c215 : 1
stoichiometry:c216 : 1

m96*m97*0.1

nodelay

--

true

0

false

PMID: 15346645, 9568715, 9422508, 12223313 Oxidized PUFAs, such as 9-HODE and 13-HODE, prostaglandin J2 and HETE, have been identified as endogenous ligands and activators of PPARg.

Go back
1309.0, 1216.5
22.5, 22.5

p79

p79

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e92 e95

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c218 : 1
stoichiometry:c219 : 1

m96*m99*0.1

nodelay

--

true

0

false

PMID: 15346645, 9568715, 9422508, 12223313 Oxidized PUFAs, such as 9-HODE and 13-HODE, prostaglandin J2 and HETE, have been identified as endogenous ligands and activators of PPARg.

Go back
1259.0, 541.0
21.0, 21.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000033291 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m11981*m16*0.1

nodelay

--

true

0

false

PMID: 15346645 IKK is an heterodimer IKKa/IKKb associated with either dimer or trimer of IKKg.

Go back
1294.0, 1158.0
19.0, 19.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e92 e97

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c221 : 1
stoichiometry:c222 : 1

m96*m101*0.1

nodelay

--

true

0

false

PMID: 15346645, 9568715, 9422508, 12223313 Oxidized PUFAs, such as 9-HODE and 13-HODE, prostaglandin J2 and HETE, have been identified as endogenous ligands and activators of PPARg.

Go back
1349.0, 1437.0
21.0, 21.0

p81

p81

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e92 e99

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c223 : 1
stoichiometry:c224 : 1
stoichiometry:c225 : 1

m96*m103*0.1

nodelay

--

true

0

false

PMID: 15346645, 9568715, 9422508, 12223313 Oxidized PUFAs, such as 9-HODE and 13-HODE, prostaglandin J2 and HETE, have been identified as endogenous ligands and activators of PPARg.

Go back
982.0, 1098.0
19.0, 19.0

p82

p82

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c227 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 15346645, 10764682, 10085242 NF-kB may enhance the pro-apoptotic effect of oxidized LDLs by up-regulating LOX-1 expression.

Go back
890.0, 1114.0
19.0, 19.0

p83

p83

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 15346645, 10508269, 10022897, 10234031 NF-kB may also up-regulate the expression of pro-apoptotic genes such as Fas ligand, Fas (Cd95), c-myc and p53,thereby sensitizing cells to apoptotic stimuli

Go back
825.0, 1105.0
21.0, 21.0

p84

p84

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

G010462

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c231 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 15346645, 10508269, 10022897, 10234031 NF-kB may also up-regulate the expression of pro-apoptotic genes such as Fas ligand, Fas (Cd95), c-myc and p53,thereby sensitizing cells to apoptotic stimuli

Go back
1164.0, 1208.0
23.0, 23.0

p85

p85

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

G010432

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c232 : 1
stoichiometry:c233 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 15346645, 10508269, 10022897, 10234031 NF-kB may also up-regulate the expression of pro-apoptotic genes such as Fas ligand, Fas (Cd95), c-myc and p53,thereby sensitizing cells to apoptotic stimuli

Go back
1198.0, 1350.0
19.0, 19.0

p86

p86

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c235 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 15346645, 10508269, 10022897, 10234031 NF-kB may also up-regulate the expression of pro-apoptotic genes such as Fas ligand, Fas (Cd95), c-myc and p53,thereby sensitizing cells to apoptotic stimuli

Go back
1095.0, 1527.0
25.0, 25.0

p87

p87

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e88 e83 e78

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c238 : 1
stoichiometry:c239 : 1
stoichiometry:c237 : 1

m91*m86*0.1

nodelay

--

true

0

false

PMID: 15346645, 9888865 oxidized LDLs significantly enhanced TF expression induced by LPS in human monocytes, whereas other reports have shown that lysoPC induce a decrease in both NFkB activation and TF expression induced by LPS.

Go back
827.0, 1515.0
25.0, 25.0

p88

p88

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c242 : 1
stoichiometry:c241 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 15346645, 11034947 NF-kB-mediated overexpression of Angiotensin Receptor-1 (AT1) which may up-regulate LOX-1 expression and enhances the toxicity of oxidized LDLs.

Go back
847.0, 1675.0
25.0, 25.0

p89

p89

cso30:i:ME_Translation

cso30:i:CC_Cell_WithoutCellWall_

--

e105

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c243 : 1

m109*0.1

nodelay

--

true

0

false

PMID: 15346645, 11034947 NF-kB-mediated overexpression of Angiotensin Receptor-1 (AT1) which may up-regulate LOX-1 expression and enhances the toxicity of oxidized LDLs.

Go back
1258.0, 388.0
23.0, 23.0

p9

p9

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000016599

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1

m1593*0.1

nodelay

--

true

0

false

PMID: 15346645 IKK is an heterodimer IKKa/IKKb associated with either dimer or trimer of IKKg.

Go back
997.0, 1053.0
21.0, 21.0

p90

p90

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e106

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1
stoichiometry:c245 : 1

m110*0.1

nodelay

--

true

0

false

PMID: 15346645, 11034947 NF-kB-mediated overexpression of Angiotensin Receptor-1 (AT1) which may up-regulate LOX-1 expression and enhances the toxicity of oxidized LDLs.

Go back
974.0, 258.0
19.0, 19.0

p91

p91

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000000104 e83

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c253 : 1
stoichiometry:c255 : 1
stoichiometry:c254 : 1

m92*m86*0.1

nodelay

--

true

0

false

PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.

Go back
938.0, 235.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.3552049089658, 346.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1107.7083183222703, 1267.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1104.3716911948197, 1329.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1105.0, 1395.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
848.0, 1339.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.2148427577599, 1194.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
890.0, 1354.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
898.0, 1413.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
898.0, 1474.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
764.0, 1436.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
783.2664073870042, 1446.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1024.1817712428262, 230.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.9691115068547, 1194.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.0, 1509.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
786.0, 1554.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
655.5298221281347, 1334.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.0, 1287.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
687.1663250237366, 1189.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
650.0, 1393.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
660.0, 1448.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
937.5627053967539, 1194.0

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
937.0, 1525.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1024.0, 293.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
976.0, 1592.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1219.0, 1592.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1220.478859290224, 1545.6287117495312

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1162.3417230863822, 1457.7193333479725

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
965.0, 1194.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1072.806745122666, 1419.7477787588057

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.6505331807703, 1427.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
535.0, 1488.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
514.0, 881.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
909.7746663552114, 907.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1113.2756982067183, 231.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
904.0, 1012.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
159.0, 1012.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1076.0, 771.5704017715636

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1202.5418346747588, 675.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1197.0, 760.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1320.0, 787.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1106.0, 1012.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1320.0, 1023.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1018.0, 907.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1034.0, 972.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1113.0, 284.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1040.374693103257, 976.8335585068652

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1027.0, 907.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1070.0, 971.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
190.0, 963.1518442999796

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
190.0, 1101.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
474.0, 1257.457050742315

c145

c145

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
446.0, 1260.0449743419604

c146

c146

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
474.0, 1334.0

c147

c147

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
446.0, 1385.3454536669276

c148

c148

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
154.0, 276.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1273.6417187543784, 326.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
995.089104705009, 907.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
997.0, 965.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
145.0, 293.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1122.8479626207359, 1367.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
140.0, 293.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
940.0, 1360.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
137.0, 293.0

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
750.1845869638607, 1119.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
138.0, 293.0

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
363.21645747403153, 333.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1270.0, 411.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
368.0, 395.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
154.0, 290.0

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
404.3517178529796, 144.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.0, 187.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
162.0, 176.0

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1035.0, 905.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1084.9402850002907, 959.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
382.0, 624.0

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 922.0

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 862.346578828079

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1218.0, 434.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
364.0, 781.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1035.0, 899.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1092.2865955178518, 947.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
394.0, 763.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
166.0, 854.6069714518937

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
203.0, 836.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
193.0, 749.5044375474413

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
289.0, 695.3861999450876

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
365.40971801578524, 641.9895013078127

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1557.0, 792.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1270.0, 514.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1453.0, 792.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1461.5080652753668, 801.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1035.0, 894.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1096.1744587445608, 920.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1187.9933444248047, 897.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
977.0, 1150.8208738733947

c185

c185

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1052.1881832090878, 1153.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1071.724568280749, 906.0

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 908.0489759203102

c188

c188

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
175.0, 925.0

c189

c189

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1116.8883324101619, 462.06827685969296

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1124.0, 1188.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.0, 1176.2460374062957

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1138.0244330827904, 910.0

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 925.0

c193

c193

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
628.854944935931, 1231.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
682.9282586084793, 1182.0

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
682.3828667696663, 902.0

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 931.0

c197

c197

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
928.8195028725718, 904.0

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
922.0, 959.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
938.0, 296.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.0, 408.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
166.0, 962.8568388473848

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 921.0

c201

c201

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
694.0, 1524.0

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.1194924244251, 1194.0

c203

c203

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
166.0, 1266.0

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 941.0

c205

c205

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
536.0, 760.6285370912865

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
963.0, 766.0

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
970.9502054869724, 757.8911973490273

c208

c208

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
156.0, 193.0

c209

c209

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1034.005708135382, 463.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1254.0, 874.0

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1253.2517885436057, 948.0

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1295.7775498066592, 900.0

c212

c212

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
158.0, 193.0

c213

c213

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1267.0, 1204.0

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1359.1420287602946, 1089.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1297.159575575166, 1215.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1267.0, 1209.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1330.0209636589962, 1245.9160574934735

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1320.0, 1239.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1022.0, 607.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1267.0, 1179.603947249397

c220

c220

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1279.0, 1135.0

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1304.0, 1177.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1263.0, 1228.0

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1360.0, 1466.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1285.68564383761, 1455.0

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
966.0, 1124.3225202593821

c226

c226

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1001.0, 1108.0

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
914.8117473356377, 1137.4975988310086

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
897.319744306791, 1071.9936076697743

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1022.0, 667.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
853.0953126733358, 1124.6954753506957

c230

c230

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
837.0, 1095.945204834583

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.0, 1183.0

c232

c232

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1182.0, 1231.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.0, 1192.0

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1200.6132233653639, 1369.0

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1118.6673351859893, 926.0

c236

c236

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1041.9957035442658, 1541.0

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
175.0, 932.0

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
137.0, 293.0

c239

c239

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1018.0, 526.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
152.0, 293.0

c240

c240

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
845.0, 1540.0

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
846.6144574458186, 1194.0

c242

c242

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
872.0, 1688.0

c243

c243

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
861.6755446134895, 1616.0

c244

c244

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1018.0, 1070.0

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1010.0685419567347, 1081.928317481452

c246

c246

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 305.74271817297625

c247

c247

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 352.2679814327163

c248

c248

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 307.10282295932694

c249

c249

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
794.0, 359.8236820569791

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
175.0, 304.6945653471075

c250

c250

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 295.7295756183097

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 284.4886845081929

c252

c252

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
955.0, 235.0

c253

c253

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
954.2950039375453, 277.0

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
175.0, 280.9484768506501

c255

c255

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
890.4408987739598, 366.93820105433286

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
876.0, 369.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
927.0, 581.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
930.0, 621.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.0, 232.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
944.0, 359.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
999.5536014515662, 454.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 488.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1114.0, 590.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1114.0, 645.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1030.0, 358.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1058.8874480940947, 415.4164522465671

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1053.0, 405.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1194.0, 584.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1194.0, 643.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.1777338982812, 299.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1110.0, 371.8819498499407

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1129.0, 331.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
884.4100608551544, 360.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
862.0, 509.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
862.0, 572.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
558.0, 378.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
577.0, 448.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.0, 459.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
558.0, 556.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.0, 607.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.0, 235.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
695.0, 359.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
715.9664359361021, 413.73205086980397

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
698.0, 421.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
698.0, 534.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
698.0, 583.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 848.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
779.0, 848.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.0, 670.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 852.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
816.0, 857.3616551718397

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
693.0, 301.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
709.0, 676.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 856.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
756.0, 859.0956050533966

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.779393692334, 649.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 809.9855387923981

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
849.0, 810.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
851.6563807250392, 701.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 855.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
814.0, 861.5298221281347

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
819.8934680842923, 748.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
559.0, 238.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.0, 859.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
786.0, 864.2463938847335

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
792.2313818857341, 716.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 777.2374351732874

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
789.0, 775.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.8560515758452, 695.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1076.0, 852.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1143.0, 852.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
558.319744306791, 299.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
971.9418702562697, 998.9626509401539

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.0, 1008.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.9368211420091, 1194.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.0, 1233.9922778767136

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
915.0, 1233.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
995.0, 1249.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1031.0, 1288.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
840.0, 1181.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
899.9936076697743, 1181.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.0, 281.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
777.422524508706, 1189.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
744.0, 1303.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
745.9083727292858, 1245.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
836.0, 1289.4437601569803

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
897.6197177650145, 1194.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.0, 1289.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
978.0, 1301.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
980.0, 1354.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.0, 1189.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1080.0, 1199.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back