1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15361242.csml convertedTime:2009.07.01.10:47

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Manipulation of mitogen-activated protein kinase/nuclear factor-kappaB-signalingcascades during intracellular Toxoplasma gondii infection.
Authors Denkers EY, Butcher BA, Del Rio L, Kim L.
Affiliation Department of Microbiology and Immunology, College of Veterinary Medicine,Cornell University, Ithaca, NY, USA. eyd1@cornell.edu
Abstract The intracellular protozoan Toxoplasma gondii exerts profound effects on nuclearfactor-kappaB (NF-kappaB)- and mitogen-activated protein kinase (MAPK)-signalingcascades in macrophages. During early infection, nuclear translocation ofNF-kappaB is blocked, and later, the cells display defects in lipopolysaccharide(LPS)-induced MAPK phosphorylation after undergoing initial activation inresponse to Toxoplasma itself. Infected macrophages that are subjected totriggering through Toll-like receptor 4 (TLR4) with LPS display defectiveproduction of tumor necrosis factor-alpha and IL-12 (IL-12) that likely reflectsinterference with NF-kappaB- and MAPK-signaling cascades. Nevertheless, T.gondii possesses molecules that themselves induce eventual proinflammatorycytokine synthesis. For interleukin-12, this occurs through both myeloiddifferentiation factor 88-dependent and chemokine receptor CCR5-dependentpathways. The balance between activation and interference with proinflammatorysignaling is likely to reflect the need to achieve an appropriate level ofimmunity that allows the host and parasite to maintain a stable interaction.
PMID 15361242
Model Abstract

Entity

e1: e10: e11:Ligand:TLR e12:MYD88 e13:Ligand:TLR:MYD88 e14:IRAK1:IRAK4 e15:Ligand:TLR:MYD88:IRAK1:IRAK4 e16:TRAF6 e17:Ligand:TLR:MYD88:IRAK1:IRAK4:TRAF6 e19:IRAK1:IRAK4:TRAF6 e2: e20:TAK1:TAB1:TAB2 e21:IRAK1:IRAK4:TRAF6:TAK1:TAB1:TAB2 e22:TRAF6:TAK1:TAB1:TAB2 e23:IKKalpha:IKKbeta:IKKgamma e24:IKKalpha:IKKbeta:IKKgamma {active} e25:IkappaB-NFkappaB e26:IkappaB{active}:NFkappaB e27:protein remnants e28:NF-kappaB e29:NF-kappaB e3: e30:IkappaB{ub}:NF-kappaB e31:IkappaB e32:IkappaB e33:IkappaB e34:IkappaB:NF-kappaB e35:MKK e36:MKK{p} e37:JNK e38:JNK{p} e39:p38 e4: e40:p38{p} e41:ERK1 e42:ERK1{p} e43:ERK2 e44:ERK2{p] e45:ATF2 e46:ATF2{active} e48:CREB e49:CREB{active} e5:Microbial ligand e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR e60: e61: e62: e64:ELK1 e65:ELK1{active} e66:c-jun e67:c-jun{active} e68:NFIL6 e69:NFIL6{active} e7: e70:TNF-alpha e71:iNOS e72:NOS2 e73:IL-12-p40 e74:gondii cell e75:IFN-gmma e76:IFN-gammaR e77:IFN-gamma:IFNgammaR e78:Stat1 e79:Stat1{p} e8: e80:Stat1{p} e81:mucin e84:PP2Ac e87:okadic acid e88:lipophosphoglycan e89:TLR2 e9: e90:Lipophosphoglycan:TLR2 e91:SHP1 e92:SHP1{active} e93:JAK2 e94:JAK2{active} e95:C-18 e96:CCR5 e97:C-18:CCR5 e98:IL20 e99:pertussis toxin

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p7 p70 p71 p72 p8 p9
Model Detail
265.60406973893026, 102.45703650750177
919.7807588420069, 1556.5863751604786

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
274.4660933081429, 126.248738483122
891.5492165428637, 1461.7560743692943

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1136.5, 298.0
31.0, 60.0

Ligand:TLR

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p2

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1064.0, 384.5
48.400702987697706, 31.460456942003514

MYD88

--

e12

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1133.5, 438.0
37.7995962561938, 52.74362268306112

Ligand:TLR:MYD88

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5 p2

p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1083.5, 528.0
32.122312947842026, 39.33344442592902

IRAK1:IRAK4

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1138.0, 586.0
36.0, 60.0

Ligand:TLR:MYD88:IRAK1:IRAK4

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p4

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1090.5, 655.0
26.13604346951097, 42.38277319380156

TRAF6

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1137.0, 716.0
38.47058823529412, 64.11764705882352

Ligand:TLR:MYD88:IRAK1:IRAK4:TRAF6

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p5

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1130.5, 923.0
35.826757203156546, 49.99082400440449

IRAK1:IRAK4:TRAF6

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p6

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
265.60406973893026, 102.45703650750177
919.7807588420069, 1556.5863751604786

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1086.5, 968.0
34.406313084969725, 48.00880895577171

TAK1:TAB1:TAB2

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p6

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1134.0, 1082.0
36.0, 60.0

IRAK1:IRAK4:TRAF6:TAK1:TAB1:TAB2

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p7

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1018.0, 210.0
36.0, 60.0

TRAF6:TAK1:TAB1:TAB2

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p18 p8

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
410.5, 309.0
43.94696274545788, 61.32134336575518

IKKalpha:IKKbeta:IKKgamma

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
570.5, 309.0
43.94696274545788, 61.32134336575518

IKKalpha:IKKbeta:IKKgamma {active}

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p9

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
417.5, 371.0
36.30812993209764, 50.6625068819967

IkappaB-NFkappaB

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p9

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
557.5, 371.0
36.426500275279864, 50.827674802716096

IkappaB{active}:NFkappaB

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p10

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
366.0, 619.0
35.083285468121765, 33.91384261918438

protein remnants

--

e27

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p12 p72

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
448.0, 762.0
32.61878453038673, 36.243093922651944

NF-kappaB

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12 p72

p11

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
551.0, 1113.0
34.06077348066298, 37.84530386740331

NF-kappaB

--

e29

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p11

p16 p47 p46 p48 p45 p13

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
283.99968491577033, 123.89762018739815
882.9895284883264, 1513.7052078006868

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
423.5, 516.0
33.790787300422096, 47.14993576803083

IkappaB{ub}:NF-kappaB

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p12 p72

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
764.0, 1451.0
48.892733564013845, 26.07612456747405

IkappaB

--

e31

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p13

p14

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
383.0, 1100.5
41.76, 31.320000000000004

IkappaB

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

p14

p15

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
589.0, 1057.5
38.56, 28.919999999999998

IkappaB

--

e33

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p15

p16

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
652.5, 1038.0
31.099834832079285, 43.3951183703432

IkappaB:NF-kappaB

--

e34

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p16

p17

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
591.0, 266.5
42.310324008854906, 26.09136647212719

MKK

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

p52

p18

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
926.0, 263.0
43.29268292682927, 34.634146341463406

MKK{p}

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

p18

p52 p20 p19 p21 p22

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
509.0, 445.5
45.27240773286467, 29.427065026362037

JNK

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p57 p19 p58

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
526.0, 570.0
44.02439024390243, 35.21951219512195

JNK{p}

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

p57 p19 p58

p28 p44 p37 p36 p23

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
641.0, 418.5
45.159991950090564, 27.848661702555848

p38

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

p53

p20 p55 p56

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
318.0315729929246, 161.41864162721654
814.925752334018, 1438.6631649210465

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
655.0, 583.0
41.463414634146346, 33.17073170731707

p38{p}

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

p20 p55 p56

p35 p38 p29 p53 p43 p24

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
800.0, 381.5
39.52, 29.639999999999997

ERK1

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p62 p61 p21

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
787.0, 528.0
41.21951219512195, 32.975609756097576

ERK1{p}

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

p62 p61 p21

p41 p25 p31 p39 p33

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
960.0, 353.5
47.442141275910636, 29.2559871201449

ERK2

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p59 p60 p22

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
956.0, 505.0
47.5609756097561, 38.048780487804876

ERK2{p]

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

p59 p60 p22

p26 p34 p30 p40 p42

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
672.0, 757.5
41.706580800965995, 25.7190581605957

ATF2

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p26 p25 p23 p24

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
714.0, 973.5
35.62084926544577, 21.96619038035822

ATF2{active}

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

p26 p25 p23 p24

p27

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
772.0, 782.5
41.28, 30.96

CREB

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p28 p30 p31 p29

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
792.0, 969.5
39.199999999999996, 29.39999999999999

CREB{active}

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

p28 p30 p31 p29

p32

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1295.0, 208.5
50.67820487019521, 31.25155966995371

Microbial ligand

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
460.30004209284994, 1000.1385237323135
518.8520945438993, 548.4291597100306

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
516.3399331236621, 1013.1354975268505
303.388375580604, 531.5370911357995

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
467.0634772172581, 1007.4584201144805
505.32522429508265, 533.789366945697

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
468.0296822350311, 1008.5845580194289
503.3928142595371, 531.5370911357995

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
460.30004209284994, 1000.1385237323135
518.8520945438993, 548.4291597100306

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
460.30004209284994, 1000.1385237323135
518.8520945438993, 548.4291597100306

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
468.0296822350311, 1008.5845580194289
503.3928142595371, 531.5370911357995

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
839.0524090597193, 1225.3661047220594
32.41502803215562, 34.201372579538386

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
754.0263674957282, 1383.02541141488
91.78947668839923, 96.84785982559055

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
460.30004209284994, 1000.1385237323135
518.8520945438993, 548.4291597100306

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1136.5, 202.0
39.0, 60.0

TLR

--

e6

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
582.5905613970561, 1243.8559105999977
16.431283461134964, 9.220901104618994

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
582.0418743322003, 1216.357001482469
56.24042414770837, 117.98950539962803

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
605.6354181209958, 1293.0981432058052
8.778993037691059, 10.232152229778038

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
912.0, 611.5
39.22671353251318, 25.497363796133566

ELK1

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p34 p35 p36 p33

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
903.0, 802.5
41.898066783831275, 27.233743409490337

ELK1{active}

--

e65

cso30:c:Protein

cso30:i:CC_Cytosol

--

p34 p35 p36 p33

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
473.0, 665.5
45.49808814650835, 28.057154357013484

c-jun

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p40 p38 p37 p39

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
523.0, 882.5
42.87784262427048, 26.441336284966795

c-jun{active}

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

p40 p38 p37 p39

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1025.0, 1209.5
37.44, 28.080000000000002

NFIL6

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p41 p44 p43 p42

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1036.0, 1449.5
39.51999999999999, 29.640000000000008

NFIL6{active}

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

p41 p44 p43 p42

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
277.6886473333114, 108.72086313428427
902.018367951354, 1489.7026931697942

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
660.0, 1331.0
47.17993079584775, 25.162629757785467

TNF-alpha

--

e70

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p45 p71

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
482.0, 1334.0
51.95501730103806, 27.709342560553637

iNOS

--

e71

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p46

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
477.0, 1256.0
45.622837370242216, 24.332179930795846

NOS2

--

e72

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p47

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
561.0, 1330.0
54.13494809688581, 28.871972318339104

IL-12-p40

--

e73

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p48 p70

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
369.5, 888.0
37.88676387047907, 55.44404468850597

gondii cell

--

e74

cso30:c:Cell

cso30:i:CC_Extracellular

--

--

p64 p51 p11 p70 p71 p72

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
198.0, 186.5
43.77138257194607, 26.992352586033416

IFN-gmma

--

e75

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p49

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
284.5, 194.0
39.0, 60.0

IFN-gammaR

--

e76

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p49

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
284.5, 334.0
31.0, 60.0

IFN-gamma:IFNgammaR

--

e77

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p49

p64 p65

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
337.0, 378.5
45.28074059166834, 27.92312336486215

Stat1

--

e78

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p64

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
338.0, 770.5
44.93056953109277, 27.707184544173884

Stat1{p}

--

e79

cso30:c:Protein

cso30:i:CC_Cytosol

--

p64

p51

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
280.9112013584795, 135.01267615754085
865.3169686194765, 1464.4148516914267

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
616.0, 1236.7227812437109
48.28738176695513, 29.777218756288995

Stat1{p}

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

p51

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
110.0, 571.0
60.0, 34.0

mucin

--

e81

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p62 p57 p59 p55

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
778.5, 187.17568927349566
26.128597303280333, 42.370698329643794

PP2Ac

--

e84

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p52 p53

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
489.0, 237.0
53.61648444070648, 30.382674516400336

okadic acid

--

e87

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p52 p53

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
506.0, 19.0
60.0, 34.0

lipophosphoglycan

--

e88

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p54

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
500.5, 106.0
39.0, 60.0

TLR2

--

e89

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p54

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
289.5046787589284, 161.3044891807971
861.3663220016101, 1445.2094178606533

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
656.5, 110.0
31.0, 60.0

Lipophosphoglycan:TLR2

--

e90

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p54

p61 p60 p63 p58 p56

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
559.5, 184.0
24.20004024954719, 39.24330851277924

SHP1

--

e91

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p63

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
418.5, 185.0
27.92312336486215, 45.28074059166835

SHP1{active}

--

e92

cso30:c:Protein

cso30:i:CC_Cytosol

--

p63

p66

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
348.0, 203.5
32.8, 24.599999999999994

JAK2

--

e93

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p66 p65

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
442.0, 262.5
35.839999999999996, 26.880000000000003

JAK2{active}

--

e94

cso30:c:Protein

cso30:i:CC_Cytosol

--

p66 p65

--

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
113.0, 1342.5
45.22036627087945, 27.885892533708997

C-18

--

e95

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p67

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
284.5, 1294.0
39.0, 60.0

CCR5

--

e96

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p67

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
292.5, 1394.0
31.0, 60.0

C-18:CCR5

--

e97

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p67

p68

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
590.0, 1402.3737024221452
51.79930795847751, 27.62629757785467

IL20

--

e98

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p68

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
468.0, 1522.5197645079897
48.49453322119428, 27.480235492010095

pertussis toxin

--

e99

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p68

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
1269.0, 317.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 e5

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m6*m5*0.1

nodelay

--

true

0

false

PMID: 15361242 The TLR family recognizes an increasingly diverse spectrum of microbial ligands.

Go back
472.0, 432.0
23.0, 23.0

p10

p10

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e26

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c33 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 15361242 When IkB molecules, most prominently IkBalpha, undergo phosphorylative activation, they are targeted for ubiquitin-dependent proteasomal degradation as a result of the activity of IkB-targeted ubiquitin ligases.

Go back
531.0, 943.0
25.0, 25.0

p11

p11

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e28 e74

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c132 : 1
stoichiometry:c31 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 15361242, 11490005 Degradation of IkB reveals NF-kB nuclear localization sequences, and the latter molecule undergoes nuclear translocation. 2 h gondii pre-infected cells fail to undergo NF-kB translocation when subjected to LPS triggering via TLR4.

Go back
450.0, 602.0
27.0, 27.0

p12

p12

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e30

e27 e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c32 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 15361242, 11490005 When IkB molecules, most prominently IkBalpha, undergo phosphorylative activation, they are targeted for ubiquitin-dependent proteasomal degradation as a result of the activity of IkB-targeted ubiquitin ligases.

Go back
660.0, 1388.0
23.0, 23.0

p13

p13

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 15361242 Genes whose promoters contain kB-binding sites are then targeted for transcriptional activation. One such NF-kB regulated gene is that encoding IkB.

Go back
392.0, 1452.0
23.0, 23.0

p14

p14

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 15361242, 8278379 Newly synthesized IkB translocates to the nucleus and binds NF-kB, terminating its activity and mediating nuclear export of the complex.

Go back
596.0, 952.0
23.0, 23.0

p15

p15

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 15361242, 8278379 Newly synthesized IkB translocates to the nucleus and binds NF-kB, terminating its activity and mediating nuclear export of the complex.

Go back
621.0, 1109.0
21.0, 21.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e29 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m29*m33*0.1

nodelay

--

true

0

false

PMID: 15361242, 8278379 Newly synthesized IkB translocates to the nucleus and binds NF-kB, terminating its activity and mediating nuclear export of the complex.

Go back
628.0, 932.0
23.0, 23.0

p17

p17

cso30:i:ME_NuclearExport

cso30:i:CC_Nucleoplasm

--

e34

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 15361242, 8278379 Newly synthesized IkB translocates to the nucleus and binds NF-kB, terminating its activity and mediating nuclear export of the complex.

Go back
711.0, 267.0
25.0, 25.0

p18

p18

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e35 e22

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c47 : 1
stoichiometry:c46 : 1

m35*m22*0.1

nodelay

--

true

0

false

PMID: 15361242 MAPKs are activated by phosphorylation of Thr-X-Tyr tripeptide motifs mediated by upstream MAPK kinases (MKKs). The MKKs in turn are activated by MKK kinases (M3Ks), a prominent one of which is TAK1.

Go back
517.0, 509.0
22.0, 22.0

p19

p19

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e37 e36

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c50 : 1
stoichiometry:c49 : 1

m37*m36*0.1

nodelay

--

true

0

false

PMID: 15361242 MAPKs are activated by phosphorylation of Thr-X-Tyr tripeptide motifs mediated by upstream MAPK kinases (MKKs). The MKKs in turn are activated by MKK kinases (M3Ks), a prominent one of which is TAK1. purifed Leishmania lipophosphoglycan activates MAPK family members in a TLR2-dependent cascade

Go back
1317.0, 389.0
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m11*m12*0.1

nodelay

--

true

0

false

PMID: 15361242 The TLR family recognizes an increasingly diverse spectrum of microbial ligands, resulting in recruitment of the adapter molecule myeloid differentiation factor 88 (MyD88).

Go back
651.0, 527.0
25.0, 25.0

p20

p20

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e39 e36

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c53 : 1
stoichiometry:c52 : 1

m39*m36*0.1

nodelay

--

true

0

false

PMID: 15361242 MAPKs are activated by phosphorylation of Thr-X-Tyr tripeptide motifs mediated by upstream MAPK kinases (MKKs). The MKKs in turn are activated by MKK kinases (M3Ks), a prominent one of which is TAK1.

Go back
757.0, 469.0
21.0, 21.0

p21

p21

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e41 e36

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c56 : 1
stoichiometry:c55 : 1

m41*m36*0.1

nodelay

--

true

0

false

PMID: 15361242 MAPKs are activated by phosphorylation of Thr-X-Tyr tripeptide motifs mediated by upstream MAPK kinases (MKKs). The MKKs in turn are activated by MKK kinases (M3Ks), a prominent one of which is TAK1.

Go back
932.0, 432.0
24.0, 24.0

p22

p22

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e43 e36

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m43*m36*0.1

nodelay

--

true

0

false

PMID: 15361242 MAPKs are activated by phosphorylation of Thr-X-Tyr tripeptide motifs mediated by upstream MAPK kinases (MKKs). The MKKs in turn are activated by MKK kinases (M3Ks), a prominent one of which is TAK1.

Go back
708.0, 884.0
23.0, 23.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e45 e38

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c62 : 1
stoichiometry:c61 : 1

m45*m38*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
682.0, 882.0
19.0, 19.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e45 e40

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c65 : 1
stoichiometry:c64 : 1

m45*m40*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
613.0, 873.0
21.0, 21.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e45 e42

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c68 : 1
stoichiometry:c67 : 1

m45*m42*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
653.0, 877.0
21.0, 21.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e45 e44

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c71 : 1
stoichiometry:c70 : 1

m45*m44*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
695.0, 1111.0
27.0, 27.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e46

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
739.0, 884.0
19.0, 19.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e48 e38

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c76 : 1
stoichiometry:c75 : 1

m48*m38*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
771.0, 876.0
19.0, 19.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e48 e40

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c79 : 1
stoichiometry:c78 : 1

m48*m40*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
1296.0, 536.0
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m13*m14*0.1

nodelay

--

true

0

false

PMID: 15361242, 12620219, 11923871 Formation of TLR:MYD88 complex in turn leads to association with IL-1 receptor-associated kinases-1 (IRAK-1) and IRAK-4.

Go back
812.0, 873.0
17.0, 17.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e48 e44

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c82 : 1
stoichiometry:c81 : 1

m48*m44*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
843.0, 868.0
19.0, 19.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e48 e42

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c84 : 1

m48*m42*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
791.0, 1127.0
25.0, 25.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e49

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
857.0, 709.0
21.0, 21.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e64 e42

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c90 : 1
stoichiometry:c89 : 1

m64*m42*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
899.0, 707.0
17.0, 17.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e64 e44

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c93 : 1
stoichiometry:c92 : 1

m64*m44*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
944.0, 704.0
23.0, 23.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e64 e40

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c96 : 1
stoichiometry:c95 : 1

m64*m40*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
991.0, 703.0
17.0, 17.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e64 e38

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c99 : 1
stoichiometry:c98 : 1

m64*m38*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
472.0, 740.0
23.0, 23.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e66 e38

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c102 : 1
stoichiometry:c101 : 1

m66*m38*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
538.0, 749.5
20.5, 20.5

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e66 e40

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c105 : 1
stoichiometry:c104 : 1

m66*m40*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
589.0, 753.0
21.0, 21.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e66 e42

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c108 : 1
stoichiometry:c107 : 1

m66*m42*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
1253.0, 665.0
21.0, 21.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m15*m16*0.1

nodelay

--

true

0

false

PMID: 15361242 Activation of the IRAK molecules results in recruitment of TNF receptor-associated factor-6 (TRAF-6).

Go back
496.0, 752.0
23.0, 23.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e66 e44

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c111 : 1
stoichiometry:c110 : 1

m66*m44*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
977.0, 1345.0
21.0, 21.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e68 e42

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c114 : 1
stoichiometry:c113 : 1

m68*m42*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
1053.0, 1329.0
21.0, 21.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e68 e44

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c117 : 1
stoichiometry:c116 : 1

m68*m44*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
1012.0, 1332.0
23.0, 23.0

p43

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e68 e40

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c120 : 1
stoichiometry:c119 : 1

m68*m40*0.1

nodelay

--

true

0

false

Go back
1093.0, 1325.0
21.0, 21.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e68 e38

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c123 : 1
stoichiometry:c122 : 1

m68*m38*0.1

nodelay

--

true

0

false

PMID: 15361242 Upon activation, MAPKs themselves activate transcription factors including NF-IL-6, Elk-1, activating transcription factor-2 (ATF-2), cyclic adenosine monophosphate-responsive element-binding protein (CREB), and c-Jun.

Go back
598.0, 1277.5
20.5, 20.5

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e29

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 15361242 NF-kappaB induced genes include IL-12(p40), TNF-a and iNOS, and NOS2 genes. parasite in a dose-dependent blockade endotoxin-induced IL-12(p40) and TNF-a production

Go back
509.0, 1289.0
21.0, 21.0

p46

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 15361242 NF-kappaB induced genes include IL-12(p40), TNF-a and iNOS, and NOS2 genes.

Go back
499.0, 1171.0
25.0, 25.0

p47

p47

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 15361242 NF-kappaB induced genes include IL-12(p40), TNF-a and iNOS, and NOS2 genes.

Go back
557.0, 1229.0
21.0, 21.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 15361242, 9104813 NF-kappaB induced genes include IL-12(p40), TNF-a and iNOS, and NOS2, genes whose products play an important role in resistance.

Go back
208.0, 260.0
23.0, 23.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e75 e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m75*m76*0.1

nodelay

--

true

0

false

PMID: 15361242 T. gondii infection blocks the ability of IFN-g to activate signal transducer and activator of transcription 1 (Stat1).

Go back
1264.0, 880.0
23.0, 23.0

p5

p5

cso30:i:ME_Dissociation

cso30:i:CC_Extracellular

--

e17

e19 e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c14 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 15361242, 12893815 Activation of the IRAK molecules results in recruitment of TNF receptor-associated factor-6 (TRAF-6), leading to dissociation of the IRAK-1/IRAK-4/TRAF-6 from the receptor complex.

Go back
447.0, 819.0
25.0, 25.0

p51

p51

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e79 e74

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c145 : 1
stoichiometry:c144 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 15361242,11465104 Stat1 undergoes phosphorylative activation but fails to translocate into nuclei of infected cells.

Go back
892.0, 219.5
24.5, 24.5

p52

p52

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

e36 e84 e87

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c153 : 1
stoichiometry:c158 : 1
stoichiometry:c155 : 1

m36*m84*0.1

nodelay

--

true

0

false

PMID: 15361242, 9707433 The MKKs are also subject to deactivation by phosphatases such as serine/ threonine protein phosphatase type-2Ca that inhibits p38 and SAPK/JNK MAPK by dephosphorylating MKK6, MKK4, and p38 MAPK itself. Inhibition of a protein phosphatase Type-2A with okadaic acid reversed tGPI-mucin-induced hyporesponsiveness allowing MAPK activation and TNF-a production

Go back
733.0, 341.0
30.0, 30.0

p53

p53

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

e40 e84 e87

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c157 : 1
stoichiometry:c159 : 1
stoichiometry:c152 : 1

m40*m84*0.1

nodelay

--

true

0

false

PMID: 15361242, 9707433 The MKKs are also subject to deactivation by phosphatases such as serine/ threonine protein phosphatase type-2Ca that inhibits p38 and SAPK/JNK MAPK by dephosphorylating MKK6, MKK4, and p38 MAPK itself.

Go back
602.0, 22.0
27.0, 27.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e88 e89

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m88*m89*0.1

nodelay

--

true

0

false

PMID: 15361242 purifed Leishmania lipophosphoglycan activates MAPK family members in a TLR2-dependent cascade.

Go back
688.0, 520.0
23.0, 23.0

p55

p55

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e39 e81

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c168 : 1
stoichiometry:c167 : 1

m39*m81*0.1

nodelay

--

true

0

false

PMID:15361242 Similar MAPK activation is observed using Trypanosoma cruzi glycosylphosphatidylinositol-anchored mucin-like glycoproteins (tGPI-mucin).

Go back
616.0, 536.0
23.0, 23.0

p56

p56

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e39 e90

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c170 : 1
stoichiometry:c169 : 1

m39*m90*0.1

nodelay

--

true

0

false

PMID: 15361242 purifed Leishmania lipophosphoglycan activates MAPK family members in a TLR2-dependent cascade

Go back
477.0, 505.0
21.0, 21.0

p57

p57

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e37 e81

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c172 : 1
stoichiometry:c171 : 1

m37*m81*0.1

nodelay

--

true

0

false

PMID: 15361242 Similar MAPK activation is observed using Trypanosoma cruzi glycosylphosphatidylinositol-anchored mucin-like glycoproteins (tGPI-mucin).

Go back
559.0, 503.0
25.0, 25.0

p58

p58

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e37 e90

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c174 : 1
stoichiometry:c173 : 1

m37*m90*0.1

nodelay

--

true

0

false

PMID: 15361242 purifed Leishmania lipophosphoglycan activates MAPK family members in a TLR2-dependent cascade

Go back
976.0, 440.0
23.0, 23.0

p59

p59

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e43 e81

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c176 : 1
stoichiometry:c175 : 1

m43*m81*0.1

nodelay

--

true

0

false

PMID: 15361242 Similar MAPK activation is observed using Trypanosoma cruzi glycosylphosphatidylinositol-anchored mucin-like glycoproteins (tGPI-mucin).

Go back
1235.0, 1099.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e19 e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m19*m20*0.1

nodelay

--

true

0

false

PMID: 15361242 IRAK-1/IRAK-4/TRAF-6 interacts at the membrane with another complex consisting of MAP3K transforming growth factor-b-activated kinase1 (TAK1) and adapter molecules TAK1-binding protein 1 (TAB1) and TAB2.

Go back
1019.0, 447.0
17.0, 17.0

p60

p60

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e43 e90

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c165 : 1
stoichiometry:c178 : 1

m43*m90*0.1

nodelay

--

true

0

false

PMID: 15361242 purifed Leishmania lipophosphoglycan activates MAPK family members in a TLR2-dependent cascade

Go back
809.0, 477.0
21.0, 21.0

p61

p61

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e41 e90

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c180 : 1
stoichiometry:c179 : 1

m41*m90*0.1

nodelay

--

true

0

false

PMID: 15361242 purifed Leishmania lipophosphoglycan activates MAPK family members in a TLR2-dependent cascade

Go back
873.0, 477.0
21.0, 21.0

p62

p62

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e41 e81

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c183 : 1
stoichiometry:c182 : 1

m41*m81*0.1

nodelay

--

true

0

false

PMID: 15361242 Similar MAPK activation is observed using Trypanosoma cruzi glycosylphosphatidylinositol-anchored mucin-like glycoproteins (tGPI-mucin).

Go back
487.0, 195.0
25.0, 25.0

p63

p63

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e91 e90

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c188 : 1
stoichiometry:c187 : 1

m91*m90*0.1

nodelay

--

true

0

false

PMID: 15361242, 10556830 Leishmania infection is associated with increased Src homology- 2 domain-containing phosphatase-1 (SHP-1) protein tyrosine phosphatase activity that results in impaired IFN-g-triggered Janus kinase-2 (JAK-2) activation.

Go back
348.0, 488.0
23.0, 23.0

p64

p64

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e78 e77 e74

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c185 : 1
stoichiometry:c206 : 1
stoichiometry:c184 : 1

m78*m77*0.1

nodelay

--

true

0

false

PMID: 15361242 T. gondii infection blocks the ability of IFN-g to activate signal transducer and activator of transcription 1 (Stat1).

Go back
354.0, 302.0
19.0, 19.0

p65

p65

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e93 e77

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c191 : 1
stoichiometry:c190 : 1

m93*m77*0.1

nodelay

--

true

0

false

PMID: 15361242, 10556830 Leishmania infection is associated with increased Src homology- 2 domain-containing phosphatase-1 (SHP-1) protein tyrosine phosphatase activity that results in impaired IFN-g-triggered Janus kinase-2 (JAK-2) activation.

Go back
377.0, 249.0
21.0, 21.0

p66

p66

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e93 e92

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c194 : 1
stoichiometry:c193 : 1

m93*0.1

nodelay

--

true

0

false

PMID: 15361242, 10556830 Leishmania infection is associated with increased Src homology- 2 domain-containing phosphatase-1 (SHP-1) protein tyrosine phosphatase activity that results in impaired IFN-g-triggered Janus kinase-2 (JAK-2) activation.

Go back
186.0, 1346.0
19.0, 19.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e95 e96

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1

m95*m96*0.1

nodelay

--

true

0

false

PMID: 15361242 The C-18 protein has been shown to trigger dendritic cell IL-12 production in a manner dependent upon binding to chemokine receptor CCR5.

Go back
535.0, 1363.0
25.0, 25.0

p68

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e97 e99

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c139 : 1
stoichiometry:c198 : 1

m97*0.1

nodelay

--

true

0

false

PMID: 15361242 The C-18 protein has been shown to trigger dendritic cell IL-12 production in a manner dependent upon binding to chemokine receptor CCR5. Chemokine receptors are seven transmembrane domain molecules that signal through G-protein-dependent pathways, and the ability of pertussis toxin, a G-protein uncoupler, to antagonize the IL-12- inducing effects of C-18 implicates this signaling cascade in parasite-driven cytokine production.

Go back
963.0, 835.0
25.0, 25.0

p7

p7

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 15361242 The complex TRAF-6/TAK1/TAB1/TAB2 translocates to the cytoplasm.

Go back
536.0, 1260.0
23.0, 23.0

p70

p70

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e74

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c134 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 15361242, 9104813 In such cells, there is also a parasite in a dose-dependent blockade endotoxin-induced IL-12(p40) and TNF-a production

Go back
674.0, 1226.0
19.0, 19.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e74

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c133 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 15361242, 9104813 In such cells, there is also a parasite in a dose-dependent blockade endotoxin-induced IL-12(p40) and TNF-a production

Go back
414.0, 642.0
27.0, 27.0

p12

p72

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e30 e74

e28 e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c205 : 1
stoichiometry:c204 : 1
stoichiometry:c135 : 1

m30*m74*0.1

nodelay

--

true

0

false

PMID: 15361242, 11490005 T. gondii efficiently triggers phosphorylative degradation of cytoplasmic IkB, despite a failure to accumulate NF-kB.

Go back
496.0, 328.0
23.0, 23.0

p8

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e23 e22

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c23 : 1
stoichiometry:c22 : 1

m23*m22*0.1

nodelay

--

true

0

false

PMID: 15361242 Subsequent activation of TAK1, a MAP3K family member, leads to IKK activation

Go back
487.0, 383.0
25.0, 25.0

p9

p9

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e25 e24

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c26 : 1
stoichiometry:c25 : 1

m25*m24*0.1

nodelay

--

true

0

false

PMID: 15361242 IkB molecules, most prominently IkBalpha, undergo phosphorylative activation.

Go back
1176.0, 247.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1174.0, 626.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
487.37072939801, 694.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.0, 763.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
491.8755378708564, 605.0

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
505.0, 694.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.2830085864283, 770.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
560.9918689199259, 616.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
513.0, 694.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
553.1105009432147, 774.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
615.5036344873324, 561.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
498.0, 694.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1117.0, 676.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
511.0, 775.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.1324217269213, 536.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
996.1013746251994, 1238.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
994.0, 1366.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
812.0, 561.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1046.0, 1238.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1057.4791383258237, 1350.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
982.0, 543.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1027.342394784387, 1238.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1027.0, 1355.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1181.6564023547028, 683.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
684.0, 616.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1051.0, 1238.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1063.808987532707, 1346.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.0, 605.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
573.0, 1151.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
619.0, 1296.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
525.2271683851237, 1151.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
512.9402850002907, 1310.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
529.8700853921454, 1148.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
503.0573097607281, 1196.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1175.0, 771.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
568.0, 1151.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
570.0, 1250.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
407.0, 921.0

c132

c132

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
684.0, 1245.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.0, 1283.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.2636750760036, 646.352465419694

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
220.0, 213.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
237.93802477467847, 235.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
230.0, 283.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.0, 1391.7776095295123

c139

c139

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1162.2316566276095, 498.6824285676111

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
360.0, 406.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
383.0, 795.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
465.0, 844.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
407.0, 847.0065027562817

c145

c145

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
501.86745234925706, 475.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
669.0, 446.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.0, 411.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
985.0, 383.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1173.3258231839584, 897.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.3343588757587, 249.9619305082008

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
684.9244824410953, 370.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
805.0, 211.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
681.0, 378.6685578425023

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
640.8968438219807, 234.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.2797621446637, 230.0

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
543.0, 233.20602987928115

c158

c158

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
543.0, 264.0

c159

c159

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1163.0, 973.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.0, 36.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
540.0, 54.78488380226497

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.0, 49.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
543.0, 475.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.3765324210899, 446.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
688.0, 154.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
429.8060044294945, 563.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
684.6428033978249, 543.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
170.0, 533.799072620973

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
638.0, 559.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1121.0, 1006.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
629.8691417371869, 170.0

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
496.0, 526.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
170.0, 519.6326527291989

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
556.5298221281347, 528.0

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.065634581688, 170.0

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
982.9457031182809, 463.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
170.0, 455.26430625478713

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
991.0, 383.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
997.6197177650145, 464.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
812.8178369248513, 498.0

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1178.0, 1112.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.0, 170.0

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
830.0, 411.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
834.4512399668456, 496.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
170.0, 490.07134316801114

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
360.0, 511.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
313.0, 394.0

c185

c185

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
519.9930645847388, 205.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.0, 208.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
519.445387664775, 146.0

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
364.0, 228.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
988.4376015698018, 866.6564023547028

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
373.0, 285.8208738733947

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
316.0, 325.05701381977434

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
371.0, 228.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
398.0, 262.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
399.6425115795681, 224.0

c194

c194

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
158.0, 1356.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
212.68855443143906, 1330.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
205.0, 1361.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
560.0, 1383.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
324.0, 1380.561777433662

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1286.9042412217725, 240.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.0, 277.9609920027185

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.0, 943.0

c202

c202

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
407.0, 937.0

c203

c203

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
432.0, 669.0

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.0, 676.9052969001128

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
361.2646706944795, 514.9912340727504

c206

c206

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
454.0, 340.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.0, 340.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.8588463465566, 243.0

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
454.0, 396.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.0, 396.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
518.8291142426931, 353.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
502.13263094474064, 406.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.0, 563.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
408.7703784930558, 620.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1176.0, 328.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
472.0, 798.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
546.0, 968.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
464.0, 629.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
454.3373412826452, 455.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.0, 1151.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
683.0, 1406.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
423.0, 1464.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
404.0, 1140.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
425.0, 977.7940053891535

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
608.0, 975.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1168.0, 334.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
585.0, 1123.5269572728178

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
616.0, 1086.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
638.0, 1087.8383001217737

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
644.8740708586411, 962.7773940633604

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.7928721853836, 429.4966569186612

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
633.0, 280.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 280.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
743.9355982368307, 242.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
529.4697761756117, 475.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.0, 531.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1112.0, 400.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
545.9470495468925, 293.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
664.0, 446.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
666.0, 552.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.907883951425, 298.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
779.2189028942252, 411.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
774.0, 490.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
783.3536382304228, 298.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
953.7497264551948, 383.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
944.2386996451351, 298.0

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
949.0, 456.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1178.5198500701624, 404.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.0, 783.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
722.0, 907.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
558.0, 605.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
692.080803958683, 783.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
696.0, 901.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
677.0, 616.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
635.1159660434203, 783.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.0, 893.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
633.8102651883261, 561.0

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.9013581567824, 783.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1171.0, 474.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
671.0, 898.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.2346156068595, 543.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
712.2931136888268, 995.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
757.287188150334, 813.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
755.0, 903.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
559.0, 605.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
783.1313708498985, 813.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.0, 895.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
682.0, 616.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1116.0, 548.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
798.0, 813.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
813.6973356022473, 890.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.2552705614929, 543.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
805.0, 813.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.877858141724, 887.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
810.0, 561.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
805.3745886903887, 999.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
879.4376015698018, 637.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
874.0, 730.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1181.2931332664082, 553.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.0, 561.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.0956050533966, 637.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
909.0, 724.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
913.8289791386326, 543.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
935.0, 637.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
930.4090509434968, 727.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.0, 608.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
942.0, 637.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.6867759713501, 720.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
570.0, 594.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back