1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15379975.csml convertedTime:2009.07.01.10:47

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4.
Authors Palsson-McDermott EM, O'Neill LA.
Affiliation Department of Biochemistry, Trinity College, Dublin, Ireland. palssone@tcd.ie
Abstract An understanding of lipopolysaccharide (LPS) signal transduction is a key goalin the effort to provide a molecular basis for the lethal effect of LPS duringseptic shock and point the way to novel therapies. Rapid progress in this fieldduring the last 6 years has resulted in the discovery of not only the receptorfor LPS - Toll-like receptor 4 (TLR4) - but also in a better appreciation of thecomplexity of the signalling pathways activated by LPS. Soon after the discoveryof TLR4, the formation of a receptor complex in response to LPS, consisting ofdimerized TLR4 and MD-2, was described. Intracellular events following theformation of this receptor complex depend on different sets of adapters. Anearly response, which is dependent on MyD88 and MyD88-like adapter (Mal), leadsto the activation of nuclear factor-kappaB (NF-kappaB). A later response to LPSmakes use of TIR-domain-containing adapter-inducing interferon-beta (TRIF) andTRIF-related adapter molecule (TRAM), and leads to the late activation ofNF-kappaB and IRF3, and to the induction of cytokines, chemokines, and othertranscription factors. As LPS signal transduction is an area of intense researchand rapid progress, this review is intended to sum up our present understandingof the events following LPS binding to TLR4, and we also attempt to create amodel of the signalling pathways activated by LPS.
PMID 15379975
Model Abstract

Entity

G010228:IFN-beta MO000000022:p38 MO000000023:JNK MO000000193:RelA-p65 MO000000210:IKK-alpha MO000000211:IKK-beta MO000000212:TRAF6 MO000000214:IL-1 MO000000248:IKK MO000001935:Btk MO000007694:IRF-3 MO000016566:IRAK-2 MO000016569:IRAK-M MO000016573:MyD88 MO000016599:IKK-gamma MO000016882:LPS MO000018132:CD14 MO000019331:TBK1 MO000019394:TLR4 MO000019406:Tollip MO000019420:LBP MO000021928:LPS:LBP MO000021929:LPS:LBP:CD14 MO000022125:TAB2 MO000022131:MD-2 MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000061958:TRIAD3 e1: e10:TAK1:TAB1 e11:LPS:TLR4:MD2 e12:LPS:(TLR4:MD2)2 e13:LTA e14:LTA:TLR4 e15:fibronectin e16:fibronectin:TLR4 e17:diterpene e18:diterpene:TLR4 e19:LPS:TLR4:MD2:MYD88 e2: e20:LPS:TLR4:MD2:MYD88:TIRAP e21:(TIRAP)2 e22:MYD88:TIRAP e23:IRAK1 e24:LPS:TLR4:MD2:MYD88:MAL:IRAK1:IRAK2 e25:IL-1R:IL-1RAcP e26:IL1:IL1R:IL1RAcP e27:IL1:IL1R:MYD88 e28:IL1:IL1R:MYD88:IRAK1:IRAK2 e29:IRAK1:IRAK2:IRAKM e3: e30:IRAK4:IRAK1:TRAF6 e31:IRAK1{p} e32:IRAK4:MYd88 e33:LPS:TLR4:MD2:MYD88:MAL:IRAK4 e34:LPS:TLR4:MD2:MYD88:MAL:IRAK1:IRAK4 e35:LPS:TLR4:MD2:MYD88:MAL:IRAK1{p}:IRAK4 e36:IRAK1{p}:IRAK4 e37:LPS:TLR4:MD2:MYD88:MAL e38:TAK1:TAB1{active} e39:NF-kappaB:IkappaB e4: e40:NF-kappaB:IkappaB{p} e41:NF-kappaB:IkappaB{p}{ub} e42:protein remnants e43:NFkappaB{active} e44:NFkappaB e45:p38{active} e46:JNK e47:IRF-3{active} e48:IFN-beta e49:LPS:TLR4:MD2:TRAM e5:LPS:MD2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR4:MD2 e60: e61: e62: e63:NF-kappaB e64:LPS:TLR4:MD2:TRAM:TRIF e65:TRAM:IRF3 e66:IRF-3{active} e67:LPS:TLR4:MD2:TRAM:TRIF:TRAF6 e68:IKKE e69:TBK1:IKKE:TRIF:IRF{p} e7: e70:TBK1:IKKE:TRIF:IRF{p} e71:IFN-beta e72:IFN-beta:IRF3:p65 e73:IL1:IL!R:MYD88:IRAK1:IRAK2:Tollip e74:IL1:IL!R:MYD88:IRAK1{p}:IRAK2:Tollip e75:PKR e76:TIRAP:PKR e77:TLR4:Btk e78:Btk:MYD88:IRAK1:MAL e79:protein remnants e8:IRAK1{p}:IRAK4:TRAF6 e80:e80 e9:IRAK1{p}:IRAK4:TRAF6:TAb2

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p6 p7 p8 p9
Model Detail
782.0, 1374.0
40.0, 40.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p37 p41

p38 p42

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
684.0, 944.0
28.0, 28.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
795.0, 951.0
30.0, 30.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
749.0, 1425.0
38.0, 38.0

RelA-p65

--

MO000000193

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m166

10

false

infinite

0

unit false false false
TRANSPATHMO000000193

--

Go back
398.0, 550.0
36.0, 36.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
456.0, 564.0
36.0, 36.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
515.0, 459.0
30.0, 30.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p26 p47

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
87.0, 287.0
38.0, 38.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
386.0, 706.0
32.0, 32.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

p30

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1115.0, 255.0
34.0, 34.0

Btk

--

MO000001935

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55 p56

true true true true

csml-variable:Double

m367

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000001935

--

Go back
904.0, 1096.0
32.0, 32.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p43 p45 p48

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1004.0, 880.0
28.0, 28.0

IRAK-2

--

MO000016566

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p17 p18

true true true true

csml-variable:Double

m1569

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
912.0, 952.0
28.0, 28.0

IRAK-M

--

MO000016569

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m1571

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016569

--

Go back
1156.0, 708.0
36.0, 36.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p13 p16 p21 p56

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
498.0, 622.0
32.0, 32.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
1631.0, 203.0
38.0, 38.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p3

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1210.0, 198.0
48.0, 48.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p2

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
1005.0, 445.0
38.0, 38.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1217.0, 377.0
38.0, 38.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p7 p8 p9 p55 p57

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
331.0, 479.0
34.0, 34.0

Tollip

--

MO000019406

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53

p40 p51

true true true true

csml-variable:Double

m3973

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000019406

--

Go back
1379.0, 203.0
38.0, 38.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p1

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
1479.0, 251.0
37.0, 37.0

LPS:LBP

--

MO000021928

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p2

true true true true

csml-variable:Double

m6254

10

false

infinite

0

unit false false false
TRANSPATHMO000021928

--

Go back
1213.0, 293.0
42.0, 42.0

LPS:LBP:CD14

--

MO000021929

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p5

true true true true

csml-variable:Double

m6255

10

false

infinite

0

unit false false false
TRANSPATHMO000021929

--

Go back
853.0, 713.0
42.0, 42.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
1272.0, 364.0
36.0, 36.0

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p4

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
1077.0, 837.0
38.0, 38.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12 p13 p54 p56

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
935.0, 319.0
29.0, 29.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p20 p21 p22

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
1025.0, 537.0
38.0, 38.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44 p46 p48

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1137.0, 413.0
29.0, 29.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p45 p46

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
422.0, 306.0
44.0, 44.0

TRIAD3

--

MO000061958

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m36851

10

false

infinite

0

unit false false false
TRANSPATHMO000061958

--

Go back
228.03156713732574, 129.68081371369158
1047.4415230463433, 1875.875971502217

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
569.0, 766.436464088398
34.70718232044199, 38.56353591160222

TAK1:TAB1

--

e10

cso30:c:Complex

cso30:i:CC_Cell

--

--

p28

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
1215.5, 548.7449073224445
36.01614975224811, 50.255092677555524

LPS:TLR4:MD2

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p6

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1214.5, 614.0
43.0, 60.0

LPS:(TLR4:MD2)2

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p10 p39

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1648.0, 545.0
60.0, 34.0

LTA

--

e13

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1102.5, 140.0
31.0, 60.0

LTA:TLR4

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1662.0, 638.245166959578
48.08435852372583, 31.254833040421794

fibronectin

--

e15

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1022.5, 140.0
31.0, 60.0

fibronectin:TLR4

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1648.0, 725.0
60.0, 34.0

diterpene

--

e17

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p9

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
946.5, 140.0
31.0, 60.0

diterpene:TLR4

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1216.0, 744.0
36.0, 60.0

LPS:TLR4:MD2:MYD88

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p11

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
228.03156713732574, 129.68081371369158
1047.4415230463433, 1875.875971502217

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1212.0, 828.0
36.0, 60.0

LPS:TLR4:MD2:MYD88:TIRAP

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

p14 p22

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1025.0, 835.1823204419888
29.535911602209946, 32.81767955801105

(TIRAP)2

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1071.5, 647.6667222129646
32.93884352607899, 40.33327778703549

MYD88:TIRAP

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1141.0, 1061.58
38.56, 28.92

IRAK1

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p14 p17 p18 p19 p20 p23 p56

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1220.0, 916.0
36.0, 60.0

LPS:TLR4:MD2:MYD88:MAL:IRAK1:IRAK2

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
246.5, 260.0
39.0, 60.0

IL-1R:IL-1RAcP

--

e25

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p15

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
250.5, 360.0
31.0, 60.0

IL1:IL1R:IL1RAcP

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

p16 p19

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
251.5, 451.3775004587999
37.71279133786015, 52.62249954120023

IL1:IL1R:MYD88

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

p17

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
250.0, 587.3529411764706
31.588235294117638, 52.64705882352941

IL1:IL1R:MYD88:IRAK1:IRAK2

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p17 p53

p51

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
933.5, 883.1464488897046
29.99504496237841, 41.85355111029547

IRAK1:IRAK2:IRAKM

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
248.9803975982527, 155.5193257178541
1005.543862124489, 1824.198947493893

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
815.5, 255.56469076894848
37.57863828225362, 52.43530923105157

IRAK4:IRAK1:TRAF6

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1062.0, 1158.5853658536587
39.268292682926834, 31.41463414634146

IRAK1{p}

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

p20

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
959.0, 704.292817679558
38.43646408839779, 42.707182320441994

IRAK4:MYd88

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1218.0, 994.0
36.0, 60.0

LPS:TLR4:MD2:MYD88:MAL:IRAK4

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22

p23

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1218.0, 1107.3529411764705
31.588235294117645, 52.64705882352942

LPS:TLR4:MD2:MYD88:MAL:IRAK1:IRAK4

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p23

p24

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1218.0, 1203.3529411764705
31.588235294117645, 52.64705882352942

LPS:TLR4:MD2:MYD88:MAL:IRAK1{p}:IRAK4

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

p25

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
652.0, 513.6132596685081
36.34806629834254, 40.38674033149172

IRAK1{p}:IRAK4

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p26

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1216.0, 1280.0
36.0, 60.0

LPS:TLR4:MD2:MYD88:MAL

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p25

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
513.0, 830.436464088398
34.70718232044199, 38.56353591160222

TAK1:TAB1{active}

--

e38

cso30:c:Complex

cso30:i:CC_Cell

--

p28

p34 p35 p36 p37 p38

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
408.5, 797.3162806198968
30.775037493751036, 37.68371938010331

NF-kappaB:IkappaB

--

e39

cso30:c:Complex

cso30:i:CC_Cell

--

--

p30

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
287.73573395096764, 200.7367217251388
928.0331894190599, 1733.7641554793229

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
425.5, 878.4757540409933
28.194800866522243, 34.52424595900685

NF-kappaB:IkappaB{p}

--

e40

cso30:c:Complex

cso30:i:CC_Cell

--

p30

p31

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
349.5, 1036.8276953841028
37.707382102982834, 46.17230461589735

NF-kappaB:IkappaB{p}{ub}

--

e41

cso30:c:Complex

cso30:i:CC_Cell

--

p31

p32

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
596.0, 1044.917863296956
32.15393452039057, 31.082136703044224

protein remnants

--

e42

cso30:c:EntityBiological

cso30:i:CC_Cell

--

p32

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
491.0, 1131.54
37.28000000000001, 27.96

NFkappaB{active}

--

e43

cso30:c:Protein

cso30:i:CC_Cell

--

p32 p40

p33

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
615.0, 1311.54
37.28000000000001, 27.96

NFkappaB

--

e44

cso30:c:Protein

cso30:i:CC_Cell

--

p33

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
683.0, 1075.0
30.0, 30.0

p38{active}

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

--

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
795.0, 1103.0
30.0, 30.0

JNK

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

--

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
918.0, 1226.0
32.0, 32.0

IRF-3{active}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36 p43

p46

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1106.0, 1378.6557657476355
48.39605554437512, 29.844234252364664

IFN-beta

--

e48

cso30:c:Protein

cso30:i:CC_Cell

--

p38 p42

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
858.0, 142.0
36.0, 60.0

LPS:TLR4:MD2:TRAM

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p39

p44

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1560.5, 396.1773037827029
35.788535244125974, 43.82269621729712

LPS:MD2

--

e5

cso30:c:Complex

cso30:i:CC_Extracellular

--

p3

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
538.9041705867544, 1219.2856960554136
405.52699001414294, 453.60951665530234

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
582.704106193496, 1230.035582155632
237.12378931925676, 439.637970967767

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
544.1903697117059, 1225.3400325200116
394.95459176423986, 441.5008437261051

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
544.9455410152705, 1226.2714688991812
393.4442491571106, 439.637970967767

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
538.9041705867544, 1219.2856960554136
405.52699001414294, 453.60951665530234

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
538.9041705867544, 1219.2856960554136
405.52699001414294, 453.60951665530234

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
544.9455410152705, 1226.2714688991812
393.4442491571106, 439.637970967767

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
834.9313215840425, 1405.5729718892128
25.33509816638494, 28.288189659636306

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
768.4762468703657, 1535.9740649728728
71.74127383862863, 80.10352860853386

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
538.9041705867544, 1219.2856960554136
405.52699001414294, 453.60951665530234

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1213.5, 480.5957820738138
32.76274165202109, 50.40421792618629

TLR4:MD2

--

e6

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p5

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
634.4846003897705, 1420.8660170507374
12.84244391442745, 7.626670499074234

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
634.0557548358825, 1398.1214808558611
43.95666927351923, 97.58992855708384

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
652.4961136530669, 1461.594605120632
6.861528862207873, 8.463083235302667

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
328.0, 1129.86
43.52, 32.64

NF-kappaB

--

e63

cso30:c:Protein

cso30:i:CC_Cell

--

--

p40

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
686.0, 134.0
36.0, 60.0

LPS:TLR4:MD2:TRAM:TRIF

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p44

p40 p41 p42 p43 p47

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
693.5, 689.7667055490751
32.85719046825529, 40.23329445092484

TRAM:IRF3

--

e65

cso30:c:Complex

cso30:i:CC_Cell

--

p45

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
866.0, 1434.0
32.0, 32.0

IRF-3{active}

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46

p50

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
544.0, 140.0
36.0, 60.0

LPS:TLR4:MD2:TRAM:TRIF:TRAF6

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p47

p29

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
947.0, 508.42
41.44, 31.08

IKKE

--

e68

cso30:c:Protein

cso30:i:CC_Cell

--

--

p48

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
834.0, 446.0
36.0, 60.0

TBK1:IKKE:TRIF:IRF{p}

--

e69

cso30:c:Complex

cso30:i:CC_Cell

--

p48

p49

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
303.69952183418684, 197.63964585537224
927.8179875446879, 1621.5578206741593

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
678.0, 430.0
36.0, 60.0

TBK1:IKKE:TRIF:IRF{p}

--

e70

cso30:c:Complex

cso30:i:CC_Cell

--

p49

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
586.0, 1493.5
60.0, 13.0

IFN-beta

--

e71

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p50

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
802.0, 1499.5
60.0, 17.0

IFN-beta:IRF3:p65

--

e72

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p50

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
252.0, 665.5
31.5, 52.5

IL1:IL!R:MYD88:IRAK1:IRAK2:Tollip

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p51

p52

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
252.0, 757.5
31.5, 52.5

IL1:IL!R:MYD88:IRAK1{p}:IRAK2:Tollip

--

e74

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p52

p53

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
875.5, 556.7325417589052
24.21493258200845, 39.267458241094786

PKR

--

e75

cso30:c:Protein

cso30:i:CC_Cell

--

--

p54

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1069.0, 330.5138121546961
38.23756906077348, 42.48618784530387

TIRAP:PKR

--

e76

cso30:c:Complex

cso30:i:CC_Cell

--

p54

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
787.5, 146.96833861023163
40.859190134977496, 50.03166138976837

TLR4:Btk

--

e77

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p55

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
618.0, 150.0
36.0, 60.0

Btk:MYD88:IRAK1:MAL

--

e78

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p56

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
332.0, 320.91786329695606
32.15393452039057, 31.082136703044224

protein remnants

--

e79

cso30:c:EntityBiological

cso30:i:CC_Cell

--

p58

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
788.5, 620.0
43.0, 60.0

IRAK1{p}:IRAK4:TRAF6

--

e8

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p26

p27

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false

--

Go back
392.5, 150.0
39.0, 60.0

e80

--

e80

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p57

p58

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
664.0, 816.0
36.0, 60.0

IRAK1{p}:IRAK4:TRAF6:TAb2

--

e9

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p27

p28

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
1489.0, 209.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019420 MO000016882

MO000021928

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3985*m155666*0.1

nodelay

--

true

0

false

PMID: 15379975 Circulating LBP recognizes LPS in the plasma and brings it to CD14.

Go back
1374.0, 714.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 MO000016573

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m12*m1572*0.1

nodelay

--

true

0

false

PMID: 15379975 MyD88 was initially shown to associate with the Type I IL-1R (IL-1RI) through its TIR domain, which subsequently also was shown to occur for TLR4.

Go back
1150.0, 798.0
23.0, 23.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e19 MO000022528

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m19*m6810*0.1

nodelay

--

true

0

false

PMID: 15379975 LPS binds, with the help of CD14, to MD-2 and TLR4. This induces homodimerization of TLR4, which in turn recruits MyD88 and Mal to the receptor complex.

Go back
1076.0, 912.0
27.0, 27.0

p12

p12

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000022528

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m6810*0.1

nodelay

--

true

0

false

PMID: 15379975 Mal has been shown to form homodimers and also to heterodimerize with MyD88.

Go back
1086.0, 762.0
19.0, 19.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000022528

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m1572*m6810*0.1

nodelay

--

true

0

false

PMID: 15379975 Mal has been shown to form homodimers and also to heterodimerize with MyD88.

Go back
1142.0, 886.0
23.0, 23.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e20 e23 MO000016566

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m20*m23*m1569*0.1

nodelay

--

true

0

false

PMID: 15379975 This appears to be true also for the TLR4/MyD88/Mal complex.

Go back
178.0, 286.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000214 e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m185*m25*0.1

nodelay

--

true

0

false

PMID: 15379975 After forming a complex with IL-1R/IL-1RAcP, MyD88 associates with IL-1R-associated kinase (IRAK)-1 and IRAK-2.

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153.0, 381.0
25.0, 25.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 MO000016573

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m26*m1572*0.1

nodelay

--

true

0

false

PMID: 15379975 After forming a complex with IL-1R/IL-1RAcP, MyD88 associates with IL-1R-associated kinase (IRAK)-1 and IRAK-2.

Go back
158.0, 498.0
23.0, 23.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 e23 MO000016566

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m27*m23*m1569*0.1

nodelay

--

true

0

false

PMID: 15379975 After forming a complex with IL-1R/IL-1RAcP, MyD88 associates with IL-1R-associated kinase (IRAK)-1 and IRAK-2.

Go back
1008.0, 956.0
19.0, 19.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 MO000016566 MO000016569

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m23*m1569*m1571*0.1

nodelay

--

true

0

false

Go back
823.0, 323.0
21.0, 21.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000039077 MO000000212 e23 e26

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c62 : 1
stoichiometry:c61 : 1

m17258*m183*m23*m26*0.1

nodelay

--

true

0

false

PMID: 15379975 IRAK4 has been shown to interact with both IRAK-1 and TNF-receptor associated factor (TRAF)-6 in response to IL-1.

Go back
1366.0, 302.0
19.0, 19.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000021928 MO000018132

MO000021929

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m6254*m2828*0.1

nodelay

--

true

0

false

PMID: 15379975 The role of LBP appears to be that of aiding LPS to dock at the LPS receptor complex by initially binding LPS and then forming a ternary complex with CD14.

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1065.0, 1105.0
21.0, 21.0

p20

p20

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e23 MO000039077

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c65 : 1
stoichiometry:c64 : 1

m23*m17258*0.1

nodelay

--

true

0

false

PMID: 15379975 IRAK-4 can phosphorylate IRAK-1.

Go back
1029.0, 713.0
25.0, 25.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000039077

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m1572*m17258*0.1

nodelay

--

true

0

false

PMID: 15379975 Co-immunoprecipitation studies have shown how only kinase-inactive IRAK-4 was able to interact with MyD88.

Go back
1392.0, 836.0
23.0, 23.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e20 MO000039077

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m20*m17258*0.1

nodelay

--

true

0

false

PMID: 15379975 A simplified model of the activation of NF-¦ÊB starts by association of IRAK-1 and IRAK-4 with the receptor complex.

Go back
1422.0, 1058.0
23.0, 23.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e33 e23

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m33*m23*0.1

nodelay

--

true

0

false

PMID: 15379975 A simplified model of the activation of NF-¦ÊB starts by association of IRAK-1 and IRAK-4 with the receptor complex.

Go back
1150.0, 1182.0
23.0, 23.0

p24

p24

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 15379975, 8837778 Autophosphorylation of IRAK-1 occurs in two substeps, giving rise to hyperphosphorylated IRAK-1, which causes dissociation from the receptor complex and association of IRAK with TRAF6.

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1156.0, 1268.0
27.0, 27.0

p25

p25

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e35

e36 e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 15379975, 8837778 Autophosphorylation of IRAK-1 occurs in two substeps, giving rise to hyperphosphorylated IRAK-1, which causes dissociation from the receptor complex and association of IRAK with TRAF6.

Go back
798.0, 522.0
23.0, 23.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e36

e8

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m183*m36*0.1

nodelay

--

true

0

false

PMID: 15379975, 8837778 Autophosphorylation of IRAK-1 occurs in two substeps, giving rise to hyperphosphorylated IRAK-1, which causes dissociation from the receptor complex and association of IRAK with TRAF6.

Go back
799.0, 835.0
21.0, 21.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cell

--

e8 MO000022125

e9

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m8*m6433*0.1

nodelay

--

true

0

false

PMID: 15379975, 10094049, 9079627, 8533096 TRAF6 then becomes activated and associated with TAB-2, which activates the MAPK kinase TAK1 (transforming growth factor-¦Â-activated kinase), which is constitutively associated with its adapter protein, TAB1.

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573.0, 837.0
25.0, 25.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e10 e9

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c88 : 1
stoichiometry:c87 : 1

m10*m9*0.1

nodelay

--

true

0

false

PMID: 15379975, 10094049, 9079627, 8533096 TRAF6 then becomes activated and associated with TAB-2, which activates the MAPK kinase TAK1 (transforming growth factor-¦Â-activated kinase), which is constitutively associated with its adapter protein, TAB1.

Go back
431.0, 651.0
21.0, 21.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cell

--

MO000000210 MO000000211 MO000016599 e67

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c144 : 1
stoichiometry:c89 : 1

m181*m182*m1593*m69*0.1

nodelay

--

true

0

false

PMID: 15379975 The activation of NF-¦ÊB starts by the assembly of a high-molecular-weight protein complex known as the signalosome. This complex is made up of inhibitory-binding protein ¦ÊB kinase (IKK)¦Á and IKK¦Â, together with a scaffolding protein named IKK¦Ã (also known as NEMO). PMID: 15379975 Subsequent events leading to the activation of NF-¦ÊB may be presumed to follow the model described above, involving the activation of components of the signalosome, followed by the ubiquitination and degradation of I¦ÊB, leading to translocation of NF-¦ÊB to the nucleus.

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1566.0, 342.0
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022131 MO000016882

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m6438*m155666*0.1

nodelay

--

true

0

false

PMID: 15379975, 12960171 LPS does indeed bind to MD-2.

Go back
475.0, 803.0
25.0, 25.0

p30

p30

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell

--

e39 MO000000248

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c95 : 1
stoichiometry:c94 : 1

m39*m207*0.1

nodelay

--

true

0

false

PMID: 15379975 Subsequent phosphorylation of a set of inhibitory-binding proteins ¦ÊB (I¦ÊB) results in their ubiquitination and degradation, releasing NF-¦ÊB which can then translocate into the nucleus.

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445.0, 961.0
21.0, 21.0

p31

p31

cso30:i:ME_Ubiquitination

cso30:i:CC_Cell

--

e40

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 15379975 Subsequent phosphorylation of a set of inhibitory-binding proteins ¦ÊB (I¦ÊB) results in their ubiquitination and degradation, releasing NF-¦ÊB which can then translocate into the nucleus.

Go back
498.0, 1046.0
27.0, 27.0

p32

p32

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cell

--

e41

e42 e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 15379975 Subsequent phosphorylation of a set of inhibitory-binding proteins ¦ÊB (I¦ÊB) results in their ubiquitination and degradation, releasing NF-¦ÊB which can then translocate into the nucleus.

Go back
498.0, 1246.0
23.0, 23.0

p33

p33

cso30:i:ME_Translocation

cso30:i:CC_Cell

--

e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 15379975 Subsequent phosphorylation of a set of inhibitory-binding proteins ¦ÊB (I¦ÊB) results in their ubiquitination and degradation, releasing NF-¦ÊB which can then translocate into the nucleus.

Go back
686.0, 1014.0
23.0, 23.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

MO000000022 e38

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c105 : 1
stoichiometry:c104 : 1

m45*m38*0.1

nodelay

--

true

0

false

PMID: 15379975 Apart from activating NF-¦ÊB, p38 and JNK MAPK, the early MyD88-dependent response to LPS also induces an early activation of IRF3 and induction of IFN-¦Â.

Go back
798.0, 1030.0
23.0, 23.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

MO000000023 e38

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c108 : 1
stoichiometry:c107 : 1

m47*m38*0.1

nodelay

--

true

0

false

PMID: 15379975 Apart from activating NF-¦ÊB, p38 and JNK MAPK, the early MyD88-dependent response to LPS also induces an early activation of IRF3 and induction of IFN-¦Â.

Go back
914.0, 1162.0
23.0, 23.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

MO000007694 e38

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c111 : 1
stoichiometry:c110 : 1

m977*m38*0.1

nodelay

--

true

0

false

PMID: 15379975 Apart from activating NF-¦ÊB, p38 and JNK MAPK, the early MyD88-dependent response to LPS also induces an early activation of IRF3 and induction of IFN-¦Â.

Go back
789.0, 1281.0
25.0, 25.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e38

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c112 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 15379975 Apart from activating NF-¦ÊB, p38 and JNK MAPK, the early MyD88-dependent response to LPS also induces an early activation of IRF3 and induction of IFN-¦Â.

Go back
976.0, 1380.0
27.0, 27.0

p38

p38

cso30:i:ME_Translation

cso30:i:CC_Cell

--

G010228 e38

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c116 : 1
stoichiometry:c114 : 1

m93217*m38*0.1

nodelay

--

true

0

false

PMID: 15379975 Apart from activating NF-¦ÊB, p38 and JNK MAPK, the early MyD88-dependent response to LPS also induces an early activation of IRF3 and induction of IFN-¦Â.

Go back
1142.0, 498.0
23.0, 23.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cell

--

e12 MO000041132

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c117 : 1
stoichiometry:c119 : 1

m12*m19005*0.1

nodelay

--

true

0

false

PMID: 15379975, 14517278, 14519765 A candidate adapter for bridging TRIF with TLR4 was identified independently by two different groups.his adapter was given the names TRAM and TICAM-2.

Go back
1618.0, 490.0
19.0, 19.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022131 MO000019394

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m6438*m3961*0.1

nodelay

--

true

0

false

PMID: 15379975 LPS does indeed bind to MD-2, which in turn associates with TLR4 via the extracellular leucine-rich repeats of TLR4, thus inducing TLR4 aggregation and signal transduction.

Go back
422.0, 1134.0
23.0, 23.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e63 e64 MO000019406

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c134 : 1
stoichiometry:c164 : 1
stoichiometry:c121 : 1

m65*m66*0.1

nodelay

--

true

0

false

PMID: 15379975 TRIF was shown to activate NF-¦ÊB when over-expressed, although not as potently as the activation of NF-¦ÊB by MyD88 and Mal. PMID: 15379975 Studies have subsequently shown Tollip to block activation of NF-¦ÊB in response to TLR4, suggesting a negative regulatory role for Tollip in TLR4 signalling.

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835.0, 1293.0
25.0, 25.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Cell

--

e64

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c127 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 15379975 TRIF was a more potent inducer of IFN-¦Â than MyD88 or Mal.

Go back
1027.0, 1334.0
23.0, 23.0

p42

p42

cso30:i:ME_Translation

cso30:i:CC_Cell

--

G010228 e64

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c123 : 1

m93217*m66*0.1

nodelay

--

true

0

false

PMID: 15379975 TRIF was a more potent inducer of IFN-¦Â than MyD88 or Mal.

Go back
959.0, 1159.0
21.0, 21.0

p43

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

MO000007694 e64

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c126 : 1
stoichiometry:c129 : 1

m977*m66*0.1

nodelay

--

true

0

false

PMID: 15379975 TRIF was shown to play a critical role in the activation of IRF3.

Go back
1086.0, 474.0
23.0, 23.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cell

--

MO000041125 e49

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m18998*m64*0.1

nodelay

--

true

0

false

PMID: 15379975, 12447441 The next adapter to be identified was given the name of TRIF. PMID: 15379975 TRAM structurally resembles Mal and appears to have no signalling role other than acting as a bridge between TLR4 and TRIF.

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860.0, 1012.0
19.0, 19.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cell

--

MO000007694 MO000041132

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m977*m19005*0.1

nodelay

--

true

0

false

PMID: 15379975, 14517278 TRAM was also shown to co-immunoprecipitate with IRF3.

Go back
964.0, 1288.0
20.0, 20.0

p46

p46

cso30:i:ME_Translocation

cso30:i:CC_Cell

--

e47 MO000041132 MO000041125

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c138 : 1

m49*m19005*m18998*0.1

nodelay

--

true

0

false

PMID: 15379975 overexpression of TRAM, together with TRIF, caused IRF3 to translocate to the nucleus.

Go back
614.0, 302.0
23.0, 23.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000212 e64

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m183*m66*0.1

nodelay

--

true

0

false

PMID: 15379975, 14530355 The model for delayed MyD88-independent activation of NF-¦ÊB involves TRIF binding to TRAF6 via several N-terminal TRAF6-binding domains on TRIF.

Go back
916.0, 440.0
23.0, 23.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cell

--

MO000019331 e68 MO000041125 MO000007694

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c149 : 1
stoichiometry:c148 : 1

m3902*m70*m18998*m977*0.1

nodelay

--

true

0

false

PMID: 15379975, 12692549 IKK¦Å, as well as TANK-binding protein (TBK)-1, act as IRF3 kinases, and TBK-1 and IKK¦Å have been shown to bind to TRIF, which has led to the proposed model of a complex of TRIF, TBK-1, IKK¦Å and IRF3, leading to phosphorylation and activation of IRF3.

Go back
763.0, 463.0
26.0, 26.0

p49

p49

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell

--

e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 15379975, 12692549 IKK¦Å, as well as TANK-binding protein (TBK)-1, act as IRF3 kinases, and TBK-1 and IKK¦Å have been shown to bind to TRIF, which has led to the proposed model of a complex of TRIF, TBK-1, IKK¦Å and IRF3, leading to phosphorylation and activation of IRF3.

Go back
1484.0, 416.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 MO000021929

e11 MO000019420 MO000018132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1

m6*m6255*0.1

nodelay

--

true

0

false

PMID: 15379975 LPS does indeed bind to MD-2, which in turn associates with TLR4 via the extracellular leucine-rich repeats of TLR4, thus inducing TLR4 aggregation and signal transduction.

Go back
702.0, 1494.0
19.0, 19.0

p50

p50

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e71 MO000000193 e66

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m73*m166*m68*0.1

nodelay

--

true

0

false

PMID: 15379975 p65 is required for the activation of the ISRE and was also shown to occur in the ISRE-binding complex together with IRF3.

Go back
324.0, 544.0
23.0, 23.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cell

--

MO000019406 e28

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m3973*m28*0.1

nodelay

--

true

0

false

PMID: 15379975 This protein was shown to reside in a complex with IRAK, and was recruited to the IL-1R complex together with IRAK in response to IL-1.

Go back
318.0, 698.0
27.0, 27.0

p52

p52

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cell

--

e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m75*0.1

nodelay

--

true

0

false

--

Go back
338.0, 762.0
27.0, 27.0

p53

p53

cso30:i:ME_Dissociation

cso30:i:CC_Cell

--

e74

MO000019406 e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 15379975 Association with MyD88 then triggers autophosphorylation of IRAK, following which Tollip dissociates from IRAK.

Go back
935.0, 775.0
25.0, 25.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cell

--

MO000022528 e75

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m6810*m77*0.1

nodelay

--

true

0

false

PMID: 15379975, 11526399 Another contender for the MyD88-independent branch of signalling pathways induced by LPS is dsRNA-dependent protein kinase (PKR), which has been shown to associate with Mal.

Go back
1156.0, 336.0
23.0, 23.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Cell

--

MO000001935 MO000019394

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c170 : 1

m367*m3961*0.1

nodelay

--

true

0

false

PMID: 15379975 Apart from being able to bind directly to TLR4, co-immunoprecipitation studies have also shown an interaction between Btk and MyD88, Mal and IRAK-1, although not with TRAF6.

Go back
1000.0, 252.0
23.0, 23.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cell

--

MO000022528 MO000001935 MO000016573 e23

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c171 : 1
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m6810*m367*m1572*m23*0.1

nodelay

--

true

0

false

PMID: 15379975 Apart from being able to bind directly to TLR4, co-immunoprecipitation studies have also shown an interaction between Btk and MyD88, Mal and IRAK-1, although not with TRAF6.

Go back
484.0, 244.0
23.0, 23.0

p57

p57

cso30:i:ME_Ubiquitination

cso30:i:CC_Cell

--

MO000019394 MO000061958

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c180 : 1
stoichiometry:c177 : 1

m3961*m36851*0.1

nodelay

--

true

0

false

PMID: 15379975, 15107846 Traid3 has been identified as a ubiquitin ligase that ubiquitinylates TLR4, leading to its down-regulation and degradation.

Go back
364.0, 256.0
23.0, 23.0

p58

p58

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cell

--

e80

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1

m82*0.1

nodelay

--

true

0

false

PMID: 15379975, 15107846 Traid3 has been identified as a ubiquitin ligase that ubiquitinylates TLR4, leading to its down-regulation and degradation.

Go back
1317.0, 589.0
25.0, 25.0

p6

p6

cso30:i:ME_Dimerization

cso30:i:CC_Extracellular

--

e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 15379975 In addition to causing MD-2/TLR4 to homodimerize, LPS also causes several other combinations of signalling proteins to become associated with the receptor complex.

Go back
1546.0, 550.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 MO000019394

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m13*m3961*0.1

nodelay

--

true

0

false

PMID: 15379975, 9851930, 10201887, 11150311, 11062499, 10644670 TLR4 also recognizes lipoteichoic acid (LTA), fibronectin, the fusion protein of respiratory syncytial virus (RSV) and taxol, a plant diterpene structurally unrelated to LPS but exhibiting LPS-mimetic effects on murine cells.

Go back
1566.0, 638.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 MO000019394

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m15*m3961*0.1

nodelay

--

true

0

false

MID: 15379975, 9851930, 10201887, 11150311, 11062499, 10644670 TLR4 also recognizes lipoteichoic acid (LTA), fibronectin, the fusion protein of respiratory syncytial virus (RSV) and taxol, a plant diterpene structurally unrelated to LPS but exhibiting LPS-mimetic effects on murine cells.

Go back
1568.0, 732.0
19.0, 19.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e17 MO000019394

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m17*m3961*0.1

nodelay

--

true

0

false

MID: 15379975, 9851930, 10201887, 11150311, 11062499, 10644670 TLR4 also recognizes lipoteichoic acid (LTA), fibronectin, the fusion protein of respiratory syncytial virus (RSV) and taxol, a plant diterpene structurally unrelated to LPS but exhibiting LPS-mimetic effects on murine cells.

Go back
1417.0, 222.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1308.0, 388.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
510.27103076532603, 1073.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
510.0, 1160.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.0, 1264.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
698.0, 972.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
698.0, 1037.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
548.0, 868.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
810.0, 981.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
810.0, 1053.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
548.0, 862.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
922.0, 1128.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1255.0, 401.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
927.0, 1185.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
548.0, 864.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
802.0, 1306.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.0, 1394.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1003.0, 1394.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
542.0, 869.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
546.0, 869.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1152.0, 442.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1165.1804964634343, 527.8208100192876

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
899.0813821572538, 200.17896070322053

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1253.998959620257, 500.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
372.0, 1146.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
445.0, 1146.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
708.0, 194.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1050.0, 1352.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.0, 1349.6056717395343

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
713.0, 194.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
712.0, 194.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
816.6788339812916, 1318.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
934.0, 1128.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.5777087639997, 1180.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1246.0, 434.2276000033892

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
878.8759986238862, 1037.9983308486833

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1058.0, 503.32332041740193

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.0, 197.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.1984811468718, 184.05755192478279

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
439.12506561371634, 194.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
878.4246907579123, 442.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.6582140329388, 737.1145955675084

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
945.0, 1258.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.1319453618936, 1308.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.6027656829656, 442.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1255.0, 323.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
975.7484559107824, 575.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
539.0, 331.8689728952183

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
635.68253731564, 194.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
578.2888620248546, 207.29269405511226

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
446.89564944152806, 200.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
946.9266413443544, 454.0809056378665

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
937.885143449429, 469.9932582089723

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
944.9601176059011, 467.3363843680743

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.6533910434308, 456.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.0, 470.9993611770303

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1258.9918361736266, 435.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
797.0, 476.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
721.8384324702432, 464.59968009596804

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
646.0, 1501.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.465257030206, 1463.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.625475464791, 1455.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
721.0, 1504.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
339.5201752525269, 513.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
282.0, 571.1214751973158

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
284.6065319346602, 567.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
284.0, 697.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1410.4282413771684, 248.22821977113804

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
289.27840938572075, 725.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
284.0, 777.7375856844859

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.1284974772422, 520.9989679583271

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
283.76170178707997, 647.0604248926732

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
350.0, 513.0

c164

c164

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
967.2636750760037, 796.352465419694

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.0, 596.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.0, 380.6174105308932

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1140.0, 289.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1185.5214432661303, 360.6336570575136

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1264.2847525831505, 245.9499378752247

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
835.1901475651512, 185.50738905617132

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1030.9830408477264, 265.5206330987648

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1015.1136066828735, 282.92211336423935

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.6497909302608, 282.5484175842297

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1015.4302033715013, 282.87111925434664

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
661.8089650743649, 185.73783326799452

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
514.8612170963158, 259.48366632522016

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
437.9349894126538, 203.36431735374478

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
384.05408123535835, 210.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.00154206186545, 279.0

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1252.0, 579.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
460.0, 273.4985898687327

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1265.320689488528, 608.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1522.0, 222.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1577.0, 562.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1255.0, 406.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1139.973671538767, 189.32120741438698

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1596.9932530560081, 650.3284898516167

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1255.0, 410.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1059.9799188933348, 189.31418573528782

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1595.0, 742.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1255.0, 415.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
983.8566879713844, 189.4496977903221

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1258.0, 656.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1500.4697761756117, 234.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1192.0, 726.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1259.6380645059696, 730.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1180.1219853038187, 783.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1115.0, 822.6499055497528

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1173.0, 818.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1091.6465269501284, 875.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1055.506694597132, 874.6098187424603

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1111.895473721262, 737.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1096.0, 789.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1089.6465269501284, 695.9738323849174

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1392.5731992484011, 277.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1172.0629791135943, 867.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1154.261298416907, 916.9957315573574

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.0, 894.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1165.0, 904.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
125.0, 299.75138075676534

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
208.95315570455566, 292.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
199.0, 309.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
185.99325305600823, 391.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
185.59873844676187, 400.50183413073347

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
178.0, 404.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1258.0, 237.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
188.61063226800843, 484.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
187.94460924202724, 519.9714484102843

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
188.286565912994, 518.3024168718673

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
180.0, 521.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1033.305871842727, 977.9230052105501

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.0, 908.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.0, 966.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
969.0455126623185, 923.2394443073428

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.0, 334.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
545.0, 342.3458335601264

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1262.9987017202122, 312.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.2225924173349, 351.32221947989376

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
834.0, 316.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
282.0, 335.77999974835365

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1093.2325781320424, 1085.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1077.0, 1126.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
952.0, 348.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1062.0, 726.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
953.0, 348.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1005.0, 726.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1248.0, 849.4437601569801

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1308.0, 355.7715799025358

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
962.0, 348.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1259.5162503469387, 859.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1254.0, 1028.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1160.0, 1070.134186368009

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1257.619907397432, 1074.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1179.1122393267751, 1147.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1173.0, 1199.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1189.2469504755443, 1243.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
687.4504848996742, 560.647795435915

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1183.0, 1288.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1595.8228656720048, 241.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
545.0, 477.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
688.0, 534.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
810.0, 545.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
810.0, 680.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.9877689940647, 755.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
708.0, 846.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
586.0, 805.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.0, 850.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
605.9917483216824, 847.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
417.34601022525817, 672.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1578.0, 365.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
421.0, 586.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
449.0459984420344, 600.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
459.5559743736493, 643.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
439.0, 816.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
455.1159660434202, 828.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
417.0, 738.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
444.0, 913.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.65685424949237, 982.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
387.0, 1060.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
525.0, 1060.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back