1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15494016.csml convertedTime:2009.07.01.10:48

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The p110delta subunit of phosphoinositide 3-kinase is required for thelipopolysaccharide response of mouse B cells.
Authors Hebeis BJ, Vigorito E, Turner M.
Affiliation Laboratory of Lymphocyte Signalling and Development, Babraham Institute,Babraham Research Campus, Cambridge CB2 4AT, UK. barbara.j.hebeis@gsk.com
Abstract PI3K (phosphoinositide 3-kinase) I(A) family members contain a regulatorysubunit and a catalytic subunit. The p110delta catalytic subunit is expressedpredominantly in haematopoietic cells. There, among other functions, itregulates antigen receptor-mediated responses. Using mice deficient in thep110delta subunit of PI3K, we investigated the role of this subunit in LPS(lipopolysaccharide)-induced B cell responses, which are mediated by Toll-likereceptor 4 and RP105. After injection of DNP-LPS (where DNP stands for2,4-dinitrophenol), p110delta(-/-) mice produced reduced levels of DNP-specificIgM and IgG when compared with wild-type mice. In vitro, the proliferation andup-regulation of surface activation markers such as CD86 and CD25 induced by LPSand an antibody against RP105 were decreased. We analysed the activation stateof key components of the LPS pathway in B cells to determine whether there was adefect in signalling in p110delta(-/-) B cells. They showed normalextracellular-signal-regulated kinase phosphorylation, but anti-RP105-inducedprotein kinase B, IkappaB (inhibitor of nuclear factor kappaB) and c-JunN-terminal kinase activation was severely reduced. This demonstrates that thep110delta subunit of PI3K is involved in the LPS response in B cells and mayrepresent a link between the innate and the adaptive immune system.
PMID 15494016
Model Abstract

Entity

G010230:IL-2Ralpha G010859:CD86 G024648:CD69 MO000000011:ERK MO000000023:JNK MO000000048:AKT MO000016653:RP105 MO000017214:IL-2Ralpha MO000017270:CD86 MO000017404:p110delta MO000019394:TLR4 MO000042409:LPS MO000063455:CD69 e1: e10:IKappaB {p} e11:PI3K e12:NF-kappaB{active} e13:NF-KappaB:IKappaB e15:wortmannin e16:ERK{p} e17:RP105:anti-RP105 e18:JNK{p} e2: e3: e4: e5:TLR4:LPS e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:anti-RP105 e60: e61: e62: e7:AKT{p} e9:RP105:LPS

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p2 p3 p4 p5 p6 p7 p8 p9
Model Detail
587.0, 827.0
33.0, 33.0

IL-2Ralpha

--

G010230

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p2 p11

true true true true

csml-variable:Double

m93219

10

false

infinite

0

unit false false false
TRANSFACG010230

--

Go back
636.0, 952.0
32.0, 32.0

CD86

--

G010859

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p9 p13

true true true true

csml-variable:Double

m93745

10

false

infinite

0

unit false false false
TRANSFACG010859

--

Go back
598.0, 894.0
35.5, 35.5

CD69

--

G024648

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p8 p12

true true true true

csml-variable:Double

m103353

10

false

infinite

0

unit false false false
TRANSFACG024648

--

Go back
249.0, 429.0
29.0, 29.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m7

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
458.0, 570.0
26.5, 26.5

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p16

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
561.0, 585.0
28.0, 28.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p17

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
608.0, 100.0
24.0, 24.0

RP105

--

MO000016653

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p14

true true true true

csml-variable:Double

m1632

10

false

infinite

0

unit false false false
InterProIPR000483
TRANSPATHMO000016653

--

Go back
1017.0, 461.0
29.5, 29.5

IL-2Ralpha

--

MO000017214

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2 p11

--

true true true true

csml-variable:Double

m2080

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000017214

--

Go back
1021.0, 629.0
29.0, 29.0

CD86

--

MO000017270

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9 p13

--

true true true true

csml-variable:Double

m2126

10

false

infinite

0

unit false false false
InterProIPR003596
TRANSPATHMO000017270

--

Go back
674.0, 198.0
28.0, 28.0

p110delta

--

MO000017404

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p2 p9 p8 p4 p5 p11 p12 p13 p16 p17

true true true true

csml-variable:Double

m2236

10

false

infinite

0

unit false false false
InterProIPR002420
TRANSPATHMO000017404

--

Go back
323.0, 95.0
26.0, 26.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
479.0, 31.0
25.0, 25.0

LPS

--

MO000042409

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p7

true true true true

csml-variable:Double

m157177

10

false

infinite

0

unit false false false
TRANSPATHMO000042409

--

Go back
1020.0, 552.0
31.0, 31.0

CD69

--

MO000063455

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8 p12

--

true true true true

csml-variable:Double

m38334

10

false

infinite

0

unit false false false
TRANSPATHMO000063455

--

Go back
127.80153678662063, 78.16717192152753
876.4620883168109, 1272.6229522360068

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
455.0, 190.0
34.51219512195122, 27.60975609756098

IKappaB {p}

--

e10

cso30:c:Protein

cso30:i:CC_Extracellular

--

p6

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
250.0, 189.5
27.999999999999996, 21.0

PI3K

--

e11

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p3 p15

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
427.0, 383.0
26.0, 26.0

NF-kappaB{active}

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6 p3 p15

--

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
412.0, 302.0
24.76243093922652, 27.513812154696137

NF-KappaB:IKappaB

--

e13

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p6 p3 p15

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
69.0, 267.0
45.79478553406224, 25.95037846930193

wortmannin

--

e15

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
361.0, 437.0
29.0, 29.0

ERK{p}

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10

--

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
709.5, 87.0
21.831177373383028, 42.25389169041877

RP105:anti-RP105

--

e17

cso30:c:Complex

cso30:i:CC_Extracellular

--

p14

p6 p2 p9 p8 p10

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
490.0, 630.0
26.5, 26.5

JNK{p}

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4 p16

--

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
127.80153678662063, 78.16717192152753
876.4620883168109, 1272.6229522360068

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
145.33077855295687, 95.69641368786377
841.4036047841388, 1237.5644687033355

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
177.75987582067904, 126.3725867789519
776.5454102486949, 1176.2121225211572

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
436.5, 82.0
22.225389169041875, 43.016882262661696

TLR4:LPS

--

e5

cso30:c:Complex

cso30:i:CC_Extracellular

--

p1

p15 p16 p17

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
296.0, 718.0
543.0899877839465, 492.522949815237

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
354.65776404370365, 729.6720778948761
317.56099844349956, 477.352838424624

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
303.07938531561933, 724.5737149359325
528.931217152708, 479.37551994337207

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
304.09072607499354, 725.5850556953064
526.9085356339591, 477.352838424624

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
296.0, 718.0
543.0899877839465, 492.522949815237

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
296.0, 718.0
543.0899877839465, 492.522949815237

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
304.09072607499354, 725.5850556953064
526.9085356339591, 477.352838424624

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
692.4455776746868, 920.2681518748403
33.92927842659062, 30.714925733545247

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
603.4475908497573, 1061.855858187229
96.07737214054916, 86.97530530618153

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
296.0, 718.0
543.0899877839465, 492.522949815237

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
707.0, 25.0
25.23076923076923, 37.84615384615385

anti-RP105

--

e6

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p14

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
424.00325436364733, 936.8731291472529
17.19886192620417, 8.280933520024242

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
423.4289356811494, 912.1774257998469
58.86766495602664, 105.96179692084806

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
448.1246390285562, 981.0956676995856
9.189098919965122, 9.189098919965135

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
609.0, 633.0
28.0, 28.0

AKT{p}

--

e7

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5 p17

--

true true true true

csml-variable:Double

m11

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
525.5, 92.0
20.172769129576846, 39.04406928305197

RP105:LPS

--

e9

cso30:c:Complex

cso30:i:CC_Extracellular

--

p7

p4 p5 p11 p12 p13 p3

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
416.0, 32.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000042409

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3961*m157177*0.1

nodelay

--

true

0

false

PMID: 15494016, 10196138 A major ligand inducing innate responses via TLR4 (Toll-like receptor 4) is LPS (lipopolysaccharide)

Go back
281.0, 341.0
21.0, 21.0

p10

p10

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e15 MO000000011 e17

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c52 : 1
stoichiometry:c36 : 1

m7*m19*0.1

nodelay

--

true

0

false

PMID: 15494016 However, preincubation ofBcells with wortmannin, a PI3K-specific inhibitor, completely abrogated ERK phosphorylation in response to anti-RP105.

Go back
736.0, 372.0
23.0, 23.0

p3

p11

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

e9 MO000017404 G010230

MO000017214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c46 : 1

m10*m2236*m93219*0.1

nodelay

--

true

0

false

PMID;15494016 up-regulation of the other three markers (CD25,CD69 and CD86) was reduced in p110 delta knockout cells.

Go back
896.0, 456.0
23.0, 23.0

p3

p12

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

G024648 e9 MO000017404

MO000063455

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c47 : 1

m103353*m10*m2236*0.1

nodelay

--

true

0

false

PMID;15494016 up-regulation of the other three markers (CD25,CD69 and CD86) was reduced in p110 delta knockout cells.

Go back
880.0, 692.0
23.0, 23.0

p3

p13

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

G010859 MO000017404 e9

MO000017270

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c48 : 1

m93745*m2236*m10*0.1

nodelay

--

true

0

false

PMID;15494016 up-regulation of the other three markers (CD25,CD69 and CD86) was reduced in p110 delta knockout cells.

Go back
652.0, 32.0
23.0, 23.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 MO000016653

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m6*m1632*0.1

nodelay

--

true

0

false

PMID: 15494016 However, preincubation ofBcells with wortmannin, a PI3K-specific inhibitor, completely abrogated ERK phosphorylation in response to anti-RP105. PMID;15494016 up-regulation of the other three markers (CD25,CD69 and CD86) was reduced in p110 delta knockout cells.

Go back
240.0, 248.0
23.0, 23.0

p3

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e13 e5 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c54 : 1

m15*m5*m13*0.1

nodelay

--

true

0

false

PMID:15494016,11369709 PI3K has been suggested to be involved in NF-¦ÊB (nuclear factor ¦ÊB) activation in the LPS response

Go back
500.0, 436.0
23.0, 23.0

p4

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e5 MO000017404 MO000000023

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m5*m2236*m21*0.1

nodelay

--

true

0

false

PMID:15494016 The activation of c-Jun N-terminal kinase and PKB was defective in p110delta knockout B cells downstream of the LPS receptor, but ERK phosphorylation in response to RP105 stimulation was not affected.

Go back
604.0, 468.0
23.0, 23.0

p4

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

MO000017404 e5 MO000000048

e7

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m2236*m5*m45*0.1

nodelay

--

true

0

false

PMID:15494016 The activation of c-Jun N-terminal kinase and PKB was defective in p110delta knockout B cells downstream of the LPS receptor, but ERK phosphorylation in response to RP105 stimulation was not affected.

Go back
872.0, 348.0
23.0, 23.0

p3

p2

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

MO000017404 G010230 e17

MO000017214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c4 : 1
stoichiometry:c33 : 1
stoichiometry:c28 : 1

m2236*m93219*m19*0.1

nodelay

--

true

0

false

PMID;15494016 up-regulation of the other three markers (CD25,CD69 and CD86) was reduced in p110 delta knockout cells.

Go back
316.0, 240.0
23.0, 23.0

p3

p3

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e9 e11 e13

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c20 : 1

m10*m13*m15*0.1

nodelay

--

true

0

false

PMID:15494016,11369709 PI3K has been suggested to be involved in NF-¦ÊB (nuclear factor ¦ÊB) activation in the LPS response

Go back
544.0, 432.0
23.0, 23.0

p4

p4

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e9 MO000000023 MO000017404

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c27 : 1
stoichiometry:c58 : 1
stoichiometry:c53 : 1

m10*m21*m2236*0.1

nodelay

--

true

0

false

PMID:15494016 The activation of c-Jun N-terminal kinase and PKB was defective in p110delta knockout B cells downstream of the LPS receptor, but ERK phosphorylation in response to RP105 stimulation was not affected.

Go back
656.0, 464.0
23.0, 23.0

p4

p5

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e9 MO000000048 MO000017404

e7

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c12 : 1
stoichiometry:c57 : 1
stoichiometry:c16 : 1

m10*m45*m2236*0.1

nodelay

--

true

0

false

PMID:15494016 The activation of c-Jun N-terminal kinase and PKB was defective in p110delta knockout B cells downstream of the LPS receptor, but ERK phosphorylation in response to RP105 stimulation was not affected.

Go back
489.0, 281.0
21.0, 21.0

p6

p6

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

MO000017404 e17 e13

e10 e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c17 : 1
stoichiometry:c7 : 1
stoichiometry:c18 : 1
stoichiometry:c8 : 1

m2236*m19*m15*0.1

nodelay

--

true

0

false

PMID:15494016 I¦ÊB phosphorylation in response to RP105 stimulation was severely reduced in p110delta knockout B cells.

Go back
562.0, 32.0
22.0, 22.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042409 MO000016653

e9

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m157177*m1632*0.1

nodelay

--

true

0

false

PMID: 15494016 LPS activates signalling through TLR4 and RP105 in parallel, leading to the activation of downstream signalling targets such as NF-¦ÊB and MAP kinases.

Go back
892.0, 528.0
23.0, 23.0

p3

p8

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

MO000017404 G024648 e17

MO000063455

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c5 : 1
stoichiometry:c14 : 1
stoichiometry:c29 : 1

m2236*m103353*m19*0.1

nodelay

--

true

0

false

PMID;15494016 up-regulation of the other three markers (CD25,CD69 and CD86) was reduced in p110 delta knockout cells.

Go back
876.0, 600.0
23.0, 23.0

p3

p9

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

MO000017404 G010859 e17

MO000017270

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c6 : 1
stoichiometry:c25 : 1
stoichiometry:c30 : 1

m2236*m93745*m19*0.1

nodelay

--

true

0

false

PMID;15494016 up-regulation of the other three markers (CD25,CD69 and CD86) was reduced in p110 delta knockout cells.

Go back
349.0, 56.594256868957544

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.0, 211.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
345.6423705614254, 263.4585775001349

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.0, 493.3843309514477

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
702.0, 223.0

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
729.0, 129.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
697.0, 226.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
629.0150575530251, 487.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
516.1407338802618, 117.0

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
478.42063305941474, 225.62499413715634

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
517.3577934305443, 218.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
447.0, 44.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.0, 263.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
270.61463169120447, 266.4530357126028

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
504.0, 43.13791053800676

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
585.4708276965785, 60.63413142072927

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
549.7186711919194, 54.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
727.0, 129.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
695.0, 226.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
479.0, 461.8335884449155

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
895.0, 369.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
915.0, 542.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 55.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
899.0, 614.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
537.0, 131.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
543.0, 131.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
731.0, 125.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
115.0, 288.0

c34

c34

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
269.0, 369.6657521072101

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
300.0, 362.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.0, 124.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
693.0, 226.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
609.0, 402.6307940059136

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
614.0, 377.923410283849

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
628.0, 485.68353124897226

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
546.0, 121.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
700.0, 226.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
667.0, 720.925173591613

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
694.0, 226.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
546.0, 128.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
759.0, 388.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
919.0, 477.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
903.0, 653.0680290823638

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.0, 44.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.0, 557.330685895906

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
628.0, 61.72456828074906

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
674.0, 55.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
308.95432095142365, 114.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.0750374920197, 455.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
263.0, 268.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
269.2679814327163, 113.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
255.6906623402203, 211.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
669.6033190044185, 226.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
566.9509148668477, 226.0

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
452.0, 125.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
663.0, 629.6688499404903

c6

c6

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
525.7902308865393, 226.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
621.0752076534684, 226.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
457.0, 125.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
475.0, 466.6492059044267

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
504.37386009425103, 459.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
580.0, 498.5731992484011

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
616.0, 491.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.0, 297.4859108504594

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.0150230995983, 302.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
345.6344888369818, 119.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back