1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15541655.csml convertedTime:2009.07.01.10:48

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The SAP family of adaptors in immune regulation.
Authors Latour S, Veillette A.
Affiliation Unite INSERM U429, Hopital Necker Enfants-Malades, 149 rue de Sevres, 75015Paris, France. latour@necker.fr
Abstract SAP and EAT-2 define a new class of adaptor proteins composed almost exclusivelyof a Src homology 2 (SH2) domain. By way of their SH2 domain, SAP-like adaptorsinteract with tyrosine-based motifs in the cytoplasmic region of SLAM-relatedreceptors, a family of immune cell-specific molecules involved inimmunoregulation. Recent findings indicate that SAP is required for thefunctions of SLAM family receptors, as a consequence of its ability to promoterecruitment of Src-related protein tyrosine kinase FynT and allow SLAM-relatedreceptors to transduce tyrosine phosphorylation signals. SAP is mutated inX-linked lymphoproliferative (XLP) syndrome, a rare inherited human diseasecharacterized by an deregulated immune response to Epstein-Barr virus infection.Several lines of evidence indicate that defects in the activities ofSLAM-related receptors caused by SAP deficiency account for the immunedysfunctions associated with XLP.
PMID 15541655
Model Abstract

Entity

G010262:IL-6 G010329:TNF-alpha G010453:IFN-gamma G010469:IL-4 G010657:IL-12 p40 MO000000008:Shc MO000000030:PI3K MO000000102:PLCgamma MO000000289:TNF-alpha MO000007384:IL-6 MO000016597:IL-1beta MO000016665:IFNgamma MO000016882:LPS MO000016922:CD40 MO000017053:IL-4 MO000017112:SHIP MO000017265:IL-12 MO000017776:LAT MO000017813:SLAM MO000017814:SAP MO000018095:CD3 MO000021014:NO MO000063033:2B4 MO000067318:NTB-A MO000070103:CD84 e1: e10: e11: e12: e13: e14: e15: e16: e17: e18: e19: e2: e20: e21: e22: e23: e24: e25: e26: e27: e28: e29: e3: e30: e31: e32:SLAM e33:SLAM: SLAM e34:CD48 e35:CD84: CD84 e36:CD84: 2B4: SAP e37:CD48: CD48: SAP e38:NTB-A e39:NTB-A: NTB-A e4: e40:NTB-A: NTB-A: SAP e41:FynT e42:SLAM: SLAM: SAP: FynT e43:SLAM: SLAM {pY}: SAP: FynT e44:SLAM: SLAM {pY}: SAP: FynT: SHIP e45:SLAM: SLAM {pY}: SAP: FynT: SHIP {pY} e46:SLAM: SLAM {pY}: SAP: FynT: SHIP {pY}: DOK-1: DOK-2: Shc; Ras-GTPase e47:DOK-1 e48:DOK-2 e49:Ras-GTPase e5:SLAM: SLAM: SAP e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:CD84: 2B4 e60: e61: e62: e63:CD-40 ligand e64:CD40: CD40 ligand e65:IL-1beta receptor e66:LPS e67:IL-1beta: IL-1beta receptor e68:LPS: LPS receptor e69:SLAM e7: e70:IFNgamma receptor e71:IFNgamma: IFNgamma receptor e72:Anti SLAM antibody e73:Anti SLAM antibody: SLAM e74:NCR e75:CD16 e76:CD84: 2B4: SAP: FynT e77:PLCgamma e78:Ca e79:2B4: LAT e8: e80:NTB-A antibody e81:NTB-A antibody: NTB-A e82:NTB-A antibody: NTB-A: SAP e83:CD84 e84:CD84: CD84{pY} e85:CD84 antibody e86:CD84 antibody: CD84 e87:CD48: CD48: SAP: CD3 e88:Lyn-9 antibody e89:Lyn-9 antibody: Lyn-9 e9: e90:Lyn-9 e91:Lyn-9 antibody: Lyn-9: SAP e92:Lyn-9 antibody: Lyn-9 {pY}: SAP e93:CARCC e94:SAP: CRACC e95:2B4: LAT {pY} e96:2B4: PI3K e97:e97

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p5 p6 p7 p8 p9
Model Detail
691.0, 707.0
26.0, 26.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p28

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
739.0, 779.0
26.0, 26.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
838.0, 734.0
28.0, 28.0

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p23

p30 p37 p40

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
849.0, 825.0
29.0, 29.0

IL-4

--

G010469

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p24

true true true true

csml-variable:Double

m93439

10

false

infinite

0

unit false false false
TRANSFACG010469

--

Go back
774.0, 826.0
27.0, 27.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p25 p29

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
1019.0, 123.0
26.0, 26.0

Shc

--

MO000000008

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
InterProIPR006020
TRANSPATHMO000000008

--

Go back
586.0, 234.0
28.0, 28.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m99

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
627.0, 507.0
26.0, 26.0

PLCgamma

--

MO000000102

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m90

10

false

infinite

0

unit false false false
TRANSPATHMO000000102

--

Go back
581.0, 905.0
30.0, 30.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
359.0, 767.0
26.0, 26.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
1203.0, 563.0
26.0, 26.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
1146.0, 886.0
28.0, 28.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30 p37 p40

p21

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
1204.0, 684.0
24.0, 24.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1087.0, 459.0
26.0, 26.0

CD40

--

MO000016922

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m1837

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000016922

--

Go back
910.0, 930.0
28.0, 28.0

IL-4

--

MO000017053

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24

--

true true true true

csml-variable:Double

m1947

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000017053

--

Go back
823.0, 163.0
25.0, 25.0

SHIP

--

MO000017112

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m2000

10

false

infinite

0

unit false false false
InterProIPR000300
TRANSPATHMO000017112

--

Go back
641.0, 933.0
30.0, 30.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25 p29

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
565.0, 193.0
30.0, 30.0

LAT

--

MO000017776

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m2533

10

false

infinite

0

unit false false false
InterProIPR000345
TRANSPATHMO000017776

--

Go back
462.0, 94.0
27.0, 27.0

SLAM

--

MO000017813

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p22 p25 p27 p28

true true true true

csml-variable:Double

m2565

10

false

infinite

0

unit false false false
TRANSPATHMO000017813

--

Go back
575.0, 287.0
26.0, 26.0

SAP

--

MO000017814

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p6 p8 p36 p43 p45

true true true true

csml-variable:Double

m2566

10

false

infinite

0

unit false false false
TRANSPATHMO000017814

--

Go back
510.0, 646.0
27.0, 27.0

CD3

--

MO000018095

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m2808

10

false

infinite

0

unit false false false
TRANSPATHMO000018095

--

Go back
525.0, 857.0
30.0, 30.0

NO

--

MO000021014

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27

--

true true true true

csml-variable:Double

m218100

10

false

infinite

0

unit false false false
TRANSPATHMO000021014

--

Go back
466.0, 218.0
28.0, 28.0

2B4

--

MO000063033

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p34 p47

true true true true

csml-variable:Double

m37916

10

false

infinite

0

unit false false false
TRANSPATHMO000063033

--

Go back
464.0, 640.0
32.0, 32.0

NTB-A

--

MO000067318

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p35

true true true true

csml-variable:Double

m42171

10

false

infinite

0

unit false false false
TRANSPATHMO000067318

--

Go back
466.0, 426.0
28.0, 28.0

CD84

--

MO000070103

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p39

true true true true

csml-variable:Double

m44946

10

false

infinite

0

unit false false false
TRANSPATHMO000070103

--

Go back
448.99760995869667, 46.87866789978759
673.2746923734293, 977.5948533262182

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
455.48456474113834, 61.820752562991515
652.6093514495626, 918.0378538097073

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
15.359344249827075, 121.31184864807459
394.89956343631, 555.5126460909737

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
22.02048052701805, 134.63412120245656
381.53046203795526, 549.2244034065437

--

e12

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false true false

--

Go back
19.58211860033439, 120.41835077340761
391.10816637917935, 575.2549280493758

--

e13

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false true false

--

Go back
11.434031800768146, 112.27026397384137
407.40433997831155, 591.5511016485083

--

e14

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false true false

--

Go back
11.434031800768146, 112.27026397384137
407.40433997831155, 591.5511016485083

--

e15

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false true false

--

Go back
34.65607917953197, 134.67750267264856
360.96024522078426, 546.7366242508937

--

e16

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false true false

--

Go back
16.786730594939407, 114.65071237088351
399.53673123820937, 566.1332280275738

--

e17

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false true false

--

Go back
97.67195681797249, 453.417071610881
221.55418430338275, 200.92530308332877

--

e18

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false true false

--

Go back
223.09555463590226, 593.69346390725
39.194874318103075, 35.4816756984934

--

e19

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false true false

--

Go back
448.99760995869667, 46.87866789978759
673.2746923734293, 977.5948533262182

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
159.73137803828487, 560.7472514375888
3.7487034588932437, 3.7487034588932464

--

e20

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false true false

--

Go back
149.65673749250914, 532.6319754958896
24.015131533534863, 43.227236760362786

--

e21

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false true false

--

Go back
149.89103145868998, 542.7066160416649
7.016295477210248, 3.3782163408790136

--

e22

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false true false

--

Go back
121.60145903323553, 458.17870919451025
129.54937406194085, 194.73663871731245

--

e23

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false true false

--

Go back
97.67195681797249, 453.417071610881
221.55418430338275, 200.92530308332877

--

e24

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false true false

--

Go back
97.67195681797249, 453.417071610881
221.55418430338275, 200.92530308332877

--

e25

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false true false

--

Go back
97.67195681797249, 453.417071610881
221.55418430338275, 200.92530308332877

--

e26

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false true false

--

Go back
259.4023855831979, 535.932596491098
13.84148810490712, 12.53018923181068

--

e27

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false true false

--

Go back
100.97257781318109, 456.51140379388914
214.95294231296526, 194.73663871731245

--

e28

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false true false

--

Go back
100.97257781318109, 456.51140379388914
214.95294231296526, 194.73663871731245

--

e29

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false true false

--

Go back
462.46310380616524, 60.34416174725618
646.3437046784925, 950.6638656312821

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
100.56000018878012, 456.0988261694879
215.7780975617678, 195.56179396611466

--

e30

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false true false

--

Go back
18.214116940051767, 124.64241678667003
383.2803470647584, 556.523063938029

--

e31

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false true false

--

Go back
398.0, 134.0
27.0, 27.0

SLAM

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000017813

--

Go back
596.625, 48.5
31.09960839860023, 38.08115314114314

SLAM: SLAM

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p1

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
390.0, 178.0
28.0, 28.0

CD48

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000070103

--

Go back
470.625, 467.5
27.327237127145477, 33.46192301283119

CD84: CD84

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p38

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
459.875, 369.5
32.25, 45.0

CD84: 2B4: SAP

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p29 p31

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
466.625, 551.5
26.82915347442093, 32.85202466255624

CD48: CD48: SAP

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p41

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
384.0, 596.0
32.0, 32.0

NTB-A

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
TRANSPATHMO000067318

--

Go back
467.625, 680.5
25.40022496250625, 31.1023162806199

NTB-A: NTB-A

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p8

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
487.37426742398225, 83.90877598032608
596.5213774428588, 903.5346371651411

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
454.625, 719.5
27.539535077487084, 33.72187968671888

NTB-A: NTB-A: SAP

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
706.0, 186.0
28.0, 28.0

FynT

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p31

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
TRANSPATHMO000060171

--

Go back
735.875, 57.5
32.25, 45.0

SLAM: SLAM: SAP: FynT

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p10

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
807.875, 53.5
32.25, 45.0

SLAM: SLAM {pY}: SAP: FynT

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p11

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
859.875, 41.5
32.25, 45.0

SLAM: SLAM {pY}: SAP: FynT: SHIP

--

e44

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

p12

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
923.875, 32.5
39.62052670214719, 55.28445586346119

SLAM: SLAM {pY}: SAP: FynT: SHIP {pY}

--

e45

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

p13

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1011.875, 24.5
39.691548908056525, 55.38355661589282

SLAM: SLAM {pY}: SAP: FynT: SHIP {pY}: DOK-1: DOK-2: Shc; Ras-GTPase

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

p24

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
907.5, 126.125
32.06782048701952, 19.77515596699537

DOK-1

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
905.5, 169.125
29.0, 21.749999999999996

DOK-2

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1022.125, 163.5
19.77515596699537, 32.06782048701952

Ras-GTPase

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
647.5, 47.0
33.894184302616225, 41.503082819530064

SLAM: SLAM: SAP

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p1

p9

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
619.5140407850646, 545.656442035018
382.17886173383556, 346.59423773627185

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
660.7922046222385, 553.8702216006009
223.47143870470083, 335.9188505370026

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
624.4958881447237, 550.2824431547015
372.2151670145179, 337.3422354969052

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
625.2075806246748, 550.9941356346525
370.7917820546151, 335.9188505370026

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
619.5140407850646, 545.656442035018
382.17886173383556, 346.59423773627185

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
619.5140407850646, 545.656442035018
382.17886173383556, 346.59423773627185

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
625.2075806246748, 550.9941356346525
370.7917820546151, 335.9188505370026

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
898.4974929259647, 687.9949380252735
23.876435397817296, 21.614457307497794

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
835.8685546902527, 787.6318852184526
67.61078559537127, 61.20555327580986

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
619.5140407850646, 545.656442035018
382.17886173383556, 346.59423773627185

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
464.625, 324.5
31.09960839860024, 38.08115314114315

CD84: 2B4

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p4

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
709.5914481232882, 699.6800573532543
12.103042998260928, 5.827391073236752

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
709.1872932589254, 682.3013981856636
41.42587359716391, 74.56657247489505

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
726.5659524265163, 730.7999819091729
6.466477829801187, 6.466477829801194

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1189.5, 460.375
36.31810193321616, 23.606766256590507

CD-40 ligand

--

e63

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p14

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1084.625, 505.5
29.899308448591906, 36.61139810031661

CD40: CD40 ligand

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

p17

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1089.375, 553.5
29.25, 45.0

IL-1beta receptor

--

e65

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p15

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1089.375, 673.5
29.25, 45.0

LPS

--

e66

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p16

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1092.375, 613.5
23.25, 45.0

IL-1beta: IL-1beta receptor

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

p18

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1092.375, 733.5
23.25, 45.0

LPS: LPS receptor

--

e68

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

p19 p25 p26 p27 p28

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
853.5, 652.0
45.0, 24.0

SLAM

--

e69

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p17 p18 p19 p20

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
457.84345738929886, 50.81258687157546
660.2727153829811, 935.5893826828955

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1089.375, 793.5
29.25, 45.0

IFNgamma receptor

--

e70

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p21

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1092.375, 845.5
23.25, 45.0

IFNgamma: IFNgamma receptor

--

e71

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p21

p20

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
395.125, 45.5
33.32450460290217, 37.725854267436425

Anti SLAM antibody

--

e72

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p22

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
546.625, 47.5
27.319071821363107, 33.45192467922013

Anti SLAM antibody: SLAM

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22

p3 p23

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
764.5, 930.125
31.89877238881063, 19.670909639766553

NCR

--

e74

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p30 p29

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
805.5, 901.125
29.32, 21.99

CD16

--

e75

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p30 p29

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
463.875, 873.5
32.25, 45.0

CD84: 2B4: SAP: FynT

--

e76

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p31

p30 p29 p32

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
692.5, 500.125
31.240000000000002, 23.429999999999996

PLCgamma

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

p32

p33

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
693.875, 381.5
27.918973308854685, 28.392176246292898

Ca

--

e78

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p33

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
468.625, 177.5
23.710006665555742, 29.032661223129477

2B4: LAT

--

e79

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p34

p46

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
460.2023500374595, 67.32483540869961
633.407483524952, 919.7076660782303

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
325.0, 717.5
25.846153846153847, 38.76923076923077

NTB-A antibody

--

e80

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p35

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
461.625, 762.5
29.27874520913181, 35.851524745875686

NTB-A antibody: NTB-A

--

e81

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p35

p36

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
462.625, 823.5
27.180261623062826, 33.28195300783202

NTB-A antibody: NTB-A: SAP

--

e82

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p36

p37

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
390.0, 430.0
28.0, 28.0

CD84

--

e83

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
TRANSPATHMO000070103

--

Go back
469.625, 518.5
21.62785369105149, 26.483086152307948

CD84: CD84{pY}

--

e84

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p38

p6

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
377.0, 937.5
26.0, 39.0

CD84 antibody

--

e85

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p39

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
537.625, 982.5
28.33973504415931, 34.70171638060324

CD84 antibody: CD84

--

e86

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p39

p40

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
468.5, 602.0
22.732211298116976, 27.83536077320446

CD48: CD48: SAP: CD3

--

e87

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1195.5, 954.0
25.01560305819941, 28.319550631923853

Lyn-9 antibody

--

e88

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p42

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
1081.5, 967.0
28.31728045325779, 34.67422096317281

Lyn-9 antibody: Lyn-9

--

e89

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p42

p43

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
466.49273043255437, 83.83708394582345
630.5156309168709, 907.6459304955032

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1079.0, 935.0
29.0, 29.0

Lyn-9

--

e90

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000144

--

Go back
1043.75, 973.0
24.5, 30.0

Lyn-9 antibody: Lyn-9: SAP

--

e91

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43

p44

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
970.75, 983.0
33.841109815030826, 41.43809365105815

Lyn-9 antibody: Lyn-9 {pY}: SAP

--

e92

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p44

--

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
1088.25, 319.0
22.515817223198592, 34.63971880492092

CARCC

--

e93

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p45

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1087.75, 381.0
24.5, 30.0

SAP: CRACC

--

e94

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p45

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
461.625, 134.5
29.09094317613731, 35.621563072821196

2B4: LAT {pY}

--

e95

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p46

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
465.625, 253.5
27.278245292451256, 33.4019330111648

2B4: PI3K

--

e96

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p47

p48

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
462.625, 283.5
27.27007998666889, 33.39193467755374

e97

--

e97

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p48

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
652.0, 128.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017814 e33

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c1 : 1
stoichiometry:c3 : 1

m2566*m33*0.1

nodelay

--

true

0

false

PMID: 15541655 SAP binds to tyrosines in the intra-cytoplasmic domain of SLAM family receptors. PMID: 15541655, 9774102, 11698418, 12928397 SAP interacts by way of its SH2 domain with tyrosine-based motifs in the cytoplasmic domain of SLAM family receptors, including SLAM, 2B4, CD84, NTB-A (Ly-108 in the mouse), Ly-9.

Go back
768.0, 120.0
23.0, 23.0

p10

p10

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 15541655 This leads to tyrosine phosphorylation of the receptor, and recruitment and activation of downstream effectors that activate cellular responses.

Go back
824.0, 120.0
23.0, 23.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e43 MO000017112

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c32 : 1
stoichiometry:c31 : 1

m43*m2000*0.1

nodelay

--

true

0

false

PMID: 15541655 Tyrosine phosphorylation of SLAM initiates signalling, by first recruiting SHIP-1 as a result of an association between phosphorylated Y315 or Y335 and the SHIP-1 SH2 domain.

Go back
863.0, 123.0
25.0, 25.0

p12

p12

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 15541655 This binding induces tyrosine phosphorylation of SHIP-1, and subsequent recruitment of the adaptors Dok-1, Dok-2 and Shc, as well as of the Ras-GTPase-activating protein (Ras-GAP).

Go back
969.0, 125.0
21.0, 21.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e45 e47 e48 e49 MO000000008

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c36 : 1

m45*m47*m48*m49*m64*0.1

nodelay

--

true

0

false

PMID: 15541655 This binding induces tyrosine phosphorylation of SHIP-1, and subsequent recruitment of the adaptors Dok-1, Dok-2 and Shc, as well as of the Ras-GTPase-activating protein (Ras-GAP).

Go back
1144.0, 460.0
23.0, 23.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016922 e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m1837*m63*0.1

nodelay

--

true

0

false

PMID: 15541655, 11544303, 11489980 expression of SLAM is markedly increased on DCs and B cells following activation through CD40, as well as in response to inflammatory stimuli such as lipopolysaccharide (LPS) or IL-1beta.

Go back
1148.0, 564.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e65 MO000016597

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m66*m1591*0.1

nodelay

--

true

0

false

PMID: 15541655, 11544303, 11489980 expression of SLAM is markedly increased on DCs and B cells following activation through CD40, as well as in response to inflammatory stimuli such as lipopolysaccharide (LPS) or IL-1beta.

Go back
1148.0, 684.0
23.0, 23.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e66 MO000016882

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m67*m155666*0.1

nodelay

--

true

0

false

PMID: 15541655, 11544303, 11489980 expression of SLAM is markedly increased on DCs and B cells following activation through CD40, as well as in response to inflammatory stimuli such as lipopolysaccharide (LPS) or IL-1beta.

Go back
887.0, 603.0
25.0, 25.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e64

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c53 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 15541655, 11544303, 11489980 expression of SLAM is markedly increased on DCs and B cells following activation through CD40, as well as in response to inflammatory stimuli such as lipopolysaccharide (LPS) or IL-1beta.

Go back
924.0, 640.0
23.0, 23.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e67

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c54 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 15541655, 11544303, 11489980 expression of SLAM is markedly increased on DCs and B cells following activation through CD40, as well as in response to inflammatory stimuli such as lipopolysaccharide (LPS) or IL-1beta.

Go back
940.0, 684.0
23.0, 23.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c55 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 15541655, 11544303, 11489980 expression of SLAM is markedly increased on DCs and B cells following activation through CD40, as well as in response to inflammatory stimuli such as lipopolysaccharide (LPS) or IL-1beta.

Go back
535.0, 323.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017814 e6

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c17 : 1

m2566*m6*0.1

nodelay

--

true

0

false

PMID: 15541655 SAP binds to tyrosines in the intra-cytoplasmic domain of SLAM family receptors. PMID: 15541655, 9774102, 11698418, 12928397 SAP interacts by way of its SH2 domain with tyrosine-based motifs in the cytoplasmic domain of SLAM family receptors, including SLAM, 2B4, CD84, NTB-A (Ly-108 in the mouse), Ly-9.

Go back
927.0, 743.0
25.0, 25.0

p20

p20

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e71

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c56 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 15541655, 12351401 expression of SLAM is enhanced after activation of macrophages with LPS and IFN-gamma.

Go back
1147.0, 803.0
25.0, 25.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e70 MO000016665

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m71*m1639*0.1

nodelay

--

true

0

false

PMID: 15541655, 12351401 expression of SLAM is enhanced after activation of macrophages with LPS and IFN-gamma.

Go back
504.0, 52.0
23.0, 23.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017813 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m2565*m73*0.1

nodelay

--

true

0

false

PMID: 15541655, 10570270 Both in human and mouse T cells, SLAM ligation by soluble anti-SLAM antibodies was observed to increase the production of TH1-type cytokines, including IFN-gamma and TNF-alpha, without affecting the production of TH2 cytokines like IL-4.

Go back
723.0, 643.0
25.0, 25.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e73

G010453

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 15541655, 10570270 Both in human and mouse T cells, SLAM ligation by soluble anti-SLAM antibodies was observed to increase the production of TH1-type cytokines, including IFN-gamma and TNF-alpha, without affecting the production of TH2 cytokines like IL-4.

Go back
860.0, 912.0
24.0, 24.0

p24

p24

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e46 G010469

MO000017053

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c69 : 1
stoichiometry:c68 : 1

m46*m93439*0.1

nodelay

--

true

0

false

PMID: 15541655 This finding established that SLAM is an activator of IL-4 production. PMID: 15541655 the role of SLAM in IL-4 production is likely to be dependent on SAP.

Go back
724.0, 904.0
23.0, 23.0

p25

p25

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657 e68 MO000017813

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c74 : 1
stoichiometry:c85 : 1
stoichiometry:c71 : 1

m93589*m69*m2565*0.1

nodelay

--

true

0

false

PMID: 15541655 Lipopolysaccharide (LPS)-induced production of IL-12, TNF-alpha and nitric oxide (NO) was diminished in slam¡Ý/¡Ý macrophages, whereas the release of IL-6 was enhanced.

Go back
638.0, 850.0
27.0, 27.0

p26

p26

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e68 G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c81 : 1

m69*m93309*0.1

nodelay

--

true

0

false

PMID: 15541655 Lipopolysaccharide (LPS)-induced production of IL-12, TNF-alpha and nitric oxide (NO) was diminished in slam¡Ý/¡Ý macrophages, whereas the release of IL-6 was enhanced.

Go back
590.0, 806.0
27.0, 27.0

p27

p27

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e68 MO000017813

MO000021014

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c83 : 1
stoichiometry:c76 : 1

m69*m2565*0.1

nodelay

--

true

0

false

PMID: 15541655 Lipopolysaccharide (LPS)-induced production of IL-12, TNF-alpha and nitric oxide (NO) was diminished in slam¡Ý/¡Ý macrophages, whereas the release of IL-6 was enhanced.

Go back
576.0, 672.0
23.0, 23.0

p28

p28

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e68 MO000017813

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c82 : 1
stoichiometry:c79 : 1

m93248*m69*0.1

nodelay

--

true

0

false

PMID: 15541655 Lipopolysaccharide (LPS)-induced production of IL-12, TNF-alpha and nitric oxide (NO) was diminished in slam¡Ý/¡Ý macrophages, whereas the release of IL-6 was enhanced.

Go back
673.0, 893.0
21.0, 21.0

p29

p29

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e36 e74 e75 e76 G010657

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c84 : 1
stoichiometry:c80 : 1
stoichiometry:c90 : 1

m36*m75*m76*m77*m93589*0.1

nodelay

--

true

0

false

PMID: 15541655, 8376943, 8326140, 10359122 Engagement of 2B4 by anti-2B4 antibodies or CD48 triggers degranulation-mediated cytotoxicity, as well as secretion of IFN-gamma and IL-2, by NK cells. PMID: 15541655 In human NK cells, 2B4-mediated cytotoxicity was shown to be dependent on co-engagement of other activating receptors such as NCRs and CD16 (Fc¦ÃRIII)

Go back
420.0, 84.0
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e32 MO000017813 e73

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c64 : 1
stoichiometry:c8 : 1

m32*m2565*0.1

nodelay

--

true

0

false

PMID: 15541655, 14988414, 10831600, 11564780 SLAM, CRACC, CD84 and NTB-A are capable of homotypic interactions, while 2B4 interacts with the CD2-related receptor CD48. PMID: 15541655 The finding that anti-SLAM antibodies could inhibit SLAM homophilic interactions in vitro favored the possibility that these antibodies were in fact antagonistic.

Go back
983.0, 859.0
25.0, 25.0

p30

p30

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010453 e74 e75 e76

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c91 : 1
stoichiometry:c94 : 1
stoichiometry:c88 : 1
stoichiometry:c87 : 1

m93423*m75*m76*m77*0.1

nodelay

--

true

0

false

PMID: 15541655, 8376943, 8326140, 10359122 Engagement of 2B4 by anti-2B4 antibodies or CD48 triggers degranulation-mediated cytotoxicity, as well as secretion of IFN-gamma and IL-2, by NK cells. PMID: 15541655 In human NK cells, 2B4-mediated cytotoxicity was shown to be dependent on co-engagement of other activating receptors such as NCRs and CD16 (Fc¦ÃRIII)

Go back
415.0, 811.0
25.0, 25.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e36 e41

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m36*m41*0.1

nodelay

--

true

0

false

PMID: 15541655 2B4-mediated protein tyrosine phosphorylation is strictly dependent on SAP, and on the aptitude of SAP to recruit FynT.

Go back
628.0, 556.0
24.0, 24.0

p32

p32

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000102 e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c100 : 1
stoichiometry:c99 : 1

m90*m77*0.1

nodelay

--

true

0

false

PMID: 15541655, 11034353, 11169415, 11815622 2B4 engagement may also trigger tyrosine phosphorylation of phospholipase C (PLC)-gamma, linker for activation of T cells (LAT) and the p85 subunit of phosphatidylinositol (PI) 3¡ì kinase.

Go back
693.0, 437.0
30.0, 30.0

p33

p33

cso30:i:ME_CytosolicCalciumIonConcentrationElevation

cso30:i:CC_Cytosol

--

e77

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 15541655 Consistent with the involvement of PLC-gamma, ligation of 2B4 can lead to intracellular Ca2+ fluxes and PI turnover.

Go back
524.0, 180.0
23.0, 23.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000063033 MO000017776

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m37916*m2533*0.1

nodelay

--

true

0

false

PMID: 15541655, 11169415, 11714782, 12077228 ndeed, 2B4 was reported to be constitutively associated with LAT in lipid rafts, by way of a dicysteine motif (CxC) located in the transmembrane portion of 2B4.

Go back
400.0, 712.0
23.0, 23.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000067318 e80

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c143 : 1

m42171*m81*0.1

nodelay

--

true

0

false

PMID: 15541655, 14988414 Antibody-mediated engagement of NTB-A on T cells was shown to induce its tyrosine phosphorylation and association with SAP.

Go back
525.0, 769.0
21.0, 21.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017814 e81

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m2566*m82*0.1

nodelay

--

true

0

false

PMID: 15541655, 14988414 Antibody-mediated engagement of NTB-A on T cells was shown to induce its tyrosine phosphorylation and association with SAP.

Go back
991.0, 823.0
25.0, 25.0

p37

p37

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010453 e82

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c113 : 1
stoichiometry:c112 : 1

m93423*m83*0.1

nodelay

--

true

0

false

PMID: 15541655 This engagement also resulted in an enhancement of TCR-mediated T-cell proliferation and production of IFN-gamma, without affecting IL-4 secretion.

Go back
576.0, 512.0
23.0, 23.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e35

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 15541655, 12928397 Biochemical analyses performed using B- and T cells showed that, upon ligation, CD84 becomes phosphorylated on tyrosine and inducibly associates with SAP.

Go back
438.0, 966.0
27.0, 27.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000070103 e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m44946*m86*0.1

nodelay

--

true

0

false

PMID: 15541655, 11564780 Ligation of CD84 by soluble anti-CD84 antibodies or a CD84-Fc fusion was reported to increase IFN-gamma production by activated T cells.

Go back
425.0, 229.0
22.0, 22.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e34 MO000063033

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m34*m37916*0.1

nodelay

--

true

0

false

PMID: 15541655, 14988414, 10831600, 11564780 SLAM, CRACC, CD84 and NTB-A are capable of homotypic interactions, while 2B4 interacts with the CD2-related receptor CD48.

Go back
960.0, 888.0
23.0, 23.0

p40

p40

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010453 e86

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m93423*m87*0.1

nodelay

--

true

0

false

PMID: 15541655, 11564780 Ligation of CD84 by soluble anti-CD84 antibodies or a CD84-Fc fusion was reported to increase IFN-gamma production by activated T cells.

Go back
512.0, 604.0
23.0, 23.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 MO000018095

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c124 : 1
stoichiometry:c123 : 1

m37*m2808*0.1

nodelay

--

true

0

false

PMID: 15541655, 12928397 Co-engagement of CD84 and CD3 was also recently observed to enhance T-cell proliferation.

Go back
1144.0, 940.0
23.0, 23.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e88 e90

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c127 : 1
stoichiometry:c126 : 1

m89*m92*0.1

nodelay

--

true

0

false

PMID: 15541655, 15096483 ligation of Ly-9 by anti-Ly-9 antibodies was observed to induce Ly-9 tyrosine phosphorylation.

Go back
1085.0, 1033.0
22.0, 22.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e89 MO000017814

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m91*m2566*0.1

nodelay

--

true

0

false

PMID: 15541655 This phosphorylation appears to be largely dependent on SAP, as it was almost abolished in T cells from sap¡Ý/¡Ý mice.

Go back
1024.0, 1032.0
23.0, 23.0

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m93*0.1

nodelay

--

true

0

false

PMID: 15541655 This phosphorylation appears to be largely dependent on SAP, as it was almost abolished in T cells from sap¡Ý/¡Ý mice.

Go back
1022.0, 322.0
27.0, 27.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e93 MO000017814

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c135 : 1
stoichiometry:c134 : 1

m95*m2566*0.1

nodelay

--

true

0

false

PMID: 15541655, 10970093 human, but not mouse CRACC, could interact with SAP in transient transfection experiments.

Go back
535.0, 135.0
25.0, 25.0

p46

p46

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e79

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m80*0.1

nodelay

--

true

0

false

PMID: 15541655, 11034353, 11169415, 11815622 2B4 engagement may also trigger tyrosine phosphorylation of phospholipase C (PLC)-gamma, linker for activation of T cells (LAT) and the p85 subunit of phosphatidylinositol (PI) 3¡ì kinase.

Go back
537.0, 225.0
21.0, 21.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000063033 MO000000030

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m37916*m99*0.1

nodelay

--

true

0

false

PMID: 15541655, 11034353, 11169415, 11815622 2B4 engagement may also trigger tyrosine phosphorylation of phospholipase C (PLC)-gamma, linker for activation of T cells (LAT) and the p85 subunit of phosphatidylinositol (PI) 3¡ì kinase.

Go back
534.0, 270.0
27.0, 27.0

p48

p48

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e96

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m98*0.1

nodelay

--

true

0

false

PMID: 15541655, 11034353, 11169415, 11815622 2B4 engagement may also trigger tyrosine phosphorylation of phospholipase C (PLC)-gamma, linker for activation of T cells (LAT) and the p85 subunit of phosphatidylinositol (PI) 3¡ì kinase.

Go back
420.0, 472.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000070103 e83

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c12 : 1
stoichiometry:c14 : 1

m44946*m84*0.1

nodelay

--

true

0

false

PMID: 15541655, 14988414, 10831600, 11564780 SLAM, CRACC, CD84 and NTB-A are capable of homotypic interactions, while 2B4 interacts with the CD2-related receptor CD48.

Go back
511.0, 555.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017814 e84

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c18 : 1

m2566*m85*0.1

nodelay

--

true

0

false

PMID: 15541655 SAP binds to tyrosines in the intra-cytoplasmic domain of SLAM family receptors. PMID: 15541655, 9774102, 11698418, 12928397 SAP interacts by way of its SH2 domain with tyrosine-based motifs in the cytoplasmic domain of SLAM family receptors, including SLAM, 2B4, CD84, NTB-A (Ly-108 in the mouse), Ly-9. PMID: 15541655, 12928397 Biochemical analyses performed using B- and T cells showed that, upon ligation, CD84 becomes phosphorylated on tyrosine and inducibly associates with SAP.

Go back
416.0, 644.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e38 MO000067318

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m38*m42171*0.1

nodelay

--

true

0

false

PMID: 15541655, 14988414, 10831600, 11564780 SLAM, CRACC, CD84 and NTB-A are capable of homotypic interactions, while 2B4 interacts with the CD2-related receptor CD48.

Go back
516.0, 724.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017814 e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m2566*m39*0.1

nodelay

--

true

0

false

PMID: 15541655 SAP binds to tyrosines in the intra-cytoplasmic domain of SLAM family receptors. PMID: 15541655, 9774102, 11698418, 12928397 SAP interacts by way of its SH2 domain with tyrosine-based motifs in the cytoplasmic domain of SLAM family receptors, including SLAM, 2B4, CD84, NTB-A (Ly-108 in the mouse), Ly-9.

Go back
708.0, 128.0
23.0, 23.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e41 e5

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m41*m5*0.1

nodelay

--

true

0

false

PMID: 15541655, 11477403, 12545173, 12545174 SAP is absolutely required for SLAM-triggered protein tyrosine phosphorylation in T cells, due to the ability of SAP to promote the recruitment and activation of Src-related protein tyrosine kinase (PTK) FynT.

Go back
625.0, 87.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.90210372263255, 235.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
491.0, 587.1941408540603

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
708.0, 475.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
708.0, 418.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
494.0, 205.58769875490663

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
554.4560373723303, 198.89957008923957

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.0, 192.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.65685424949237, 672.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.0, 727.4452121626267

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.8719668456605, 313.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
491.0, 780.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
441.0, 251.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
495.65685424949237, 790.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
866.0, 756.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1016.0, 841.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
490.0, 836.0638702198254

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
498.0, 489.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
498.98014337809417, 525.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.40572720527666, 454.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
403.0, 962.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
465.0, 983.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
863.0, 762.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
413.0, 458.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.0, 904.8565241567273

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
983.0, 900.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
493.0, 583.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
499.0, 616.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
524.0, 635.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1174.64051309449, 957.3711937189796

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1117.0703033307766, 959.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1108.0, 951.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1096.0, 1002.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
601.0, 299.58589941132436

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.907883951425, 453.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1071.5876987549066, 1009.5538553641524

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1042.8372338729644, 1003.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1011.1192895849364, 1023.1530859662622

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1057.0, 336.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1049.0, 348.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.0, 301.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 160.36538537149946

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
498.9917483216824, 149.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
494.0, 233.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
565.7611400011626, 239.94028500029066

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
443.0, 484.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
500.1554175279993, 241.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
493.0, 273.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.80106284633166, 287.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
423.0, 733.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.8645518005331, 313.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
491.0, 541.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
498.34647460872225, 346.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.0, 568.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
410.0, 628.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
594.0, 158.21797169264596

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
447.0, 656.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
439.0, 664.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
531.0800449755452, 313.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
493.0, 707.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
490.0, 736.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 159.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.0, 89.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
727.0, 110.09773440987676

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
764.0, 103.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.0, 103.30004000806069

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
664.0, 97.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
829.0, 99.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
843.0, 93.84158265243214

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
836.0, 151.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
876.0, 87.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
888.0, 88.94635316997733

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
957.0, 88.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
987.0, 86.79245283018868

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.0, 136.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.0, 148.73912360382013

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
996.1143318680631, 150.15896751367828

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
565.848442145943, 311.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
998.0, 136.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1113.0, 472.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1175.0, 472.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1120.8551517954509, 483.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1119.0, 576.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1179.0, 576.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1121.4130023147422, 587.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1119.0, 696.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1179.0, 696.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1121.4130023147422, 707.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0, 338.81623092398854

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
919.277158526366, 531.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
954.9629697615171, 637.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
970.4396857613915, 702.9412711149687

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
885.5777087639997, 628.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
906.8446454055273, 655.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
906.3251522415303, 676.2159204962816

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
888.5942568689576, 682.5492597919182

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1119.0, 816.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1160.0, 836.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1121.8421713081511, 828.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
417.0, 114.40873887815638

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
958.5978308147678, 768.5242268444122

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
489.0, 80.9619305082008

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
428.0, 64.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.0, 64.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
446.8805700005813, 67.0

c64

c64

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
565.0, 81.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
748.0, 666.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
891.9981894411155, 52.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
884.0, 928.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
865.0, 854.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
450.7365962981012, 101.03594639423716

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
748.5267399752993, 853.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
678.4374520037236, 921.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.9348370334051, 757.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
672.7810789392598, 759.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
754.3365604500259, 761.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
671.4623275828736, 801.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
561.1601724872445, 831.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
606.6299136967518, 689.4050814913675

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
606.9249690339478, 687.0930991770963

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
392.3089135241743, 689.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
443.0, 71.23188337011916

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.8220353187476, 849.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
616.6568542494924, 877.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
479.0, 121.0

c82

c82

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
478.0, 121.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
496.0, 897.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
480.0, 121.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
866.0, 760.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1008.0, 874.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0, 873.3610281096023

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
485.0, 415.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
414.0, 206.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
670.2719439311038, 914.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.0, 878.407098302245

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
701.5121497996619, 910.7509280956508

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
701.9885450581608, 905.4279577709729

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
835.0, 876.7911800874873

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
429.8834522085988, 415.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
437.3870708148285, 214.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
437.0, 836.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
640.0, 533.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
652.0, 529.0335858293437

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back