1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15546391.csml convertedTime:2009.07.01.10:48

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.
Authors Watford WT, Hissong BD, Bream JH, Kanno Y, Muul L, O'Shea JJ.
Affiliation Molecular Immunology & Inflammation Branch, NIAMS, National Institutes ofHealth, Bethesda, MD 20892-1820, USA.
Abstract Produced in response to a variety of pathogenic organisms, interleukin (IL)-12and IL-23 are key immunoregulatory cytokines that coordinate innate and adaptiveimmune responses. These dimeric cytokines share a subunit, designated p40, andbind to a common receptor chain, IL-12R beta 1. The receptor for IL-12 iscomposed of IL-12R beta 1 and IL-12R beta 2, whereas IL-23 binds to a receptorcomposed of IL-12R beta 1 and IL-23R. Both cytokines activate the Janus kinasesTyk2 and Jak2, the transcription factor signal transducer and activator oftranscription 4 (STAT4), as well as other STATs. A major action of IL-12 is topromote the differentiation of naive CD4+ T cells into T-helper (Th) 1 cells,which produce interferon (IFN)-gamma, and deficiency of IL-12, IL-12R subunitsor STAT4 is similar in many respects. In contrast, IL-23 promotes end-stageinflammation. Targeting IL-12, IL-23, and their downstream signaling elementswould therefore be logical strategies for the treatment of immune-mediateddiseases.
PMID 15546391
Model Abstract

Entity

MO000000022:p38 MO000000030:PI3K{active} MO000000048:AKT MO000000049:c-Jun MO000000058:NF-kappaB MO000000138:Lck MO000000146:Jak2 MO000000148:Tyk2 MO000000192:c-Rel MO000000194:RelB MO000000200:p50 MO000007321:IL-13 MO000007685:IRF-1 MO000013119:STAT1{active} MO000013122:STAT3 MO000013130:STAT6 MO000016876:STAT5 MO000016882:LPS MO000016949:IL-11 MO000016966:MKK3 MO000017053:IL-4 MO000017061:IL-2 MO000017063:IL-15 MO000017121:SOCS-3 MO000017181:STAT4 MO000017247:IL-10 MO000017265:IL-12 MO000017462:CBP MO000019005:MKK6 MO000019512:IL-21 MO000021607:STAT3{p} MO000033720:STAT4{pY} MO000034025:IL-12Rbeta1 MO000034026:IL-12Rbeta2 MO000034420:sphingosine MO000038355:MKK6{p} MO000038421:Lck{p} MO000043605:IL-12A MO000043607:IL-12B MO000090987:T-bet e1: e10: e11:MCP1:MCP1 receptor e12:prostaglandin E2:prostaglandin E2 receptor e13:histamine:histamine receptor e14:FcR crosslinking e15:CCR5 receptor: CCR5 ligand e16:cholera toxin e17:IL12-p40 e18:IL12-p40:transcription factors e19:ICSBP e2: e20:Ets e21:IL-12Rbeta1:TYK2:IL-12A e22:IL-12Rbeta2:JAk2{p}:IL-12B e23:IFN-gamma e24:TBX21 e25:IL12Rbeta2 e26:IL-23R e27:IL-23 e28:IL-23:IL-12betaR1:TYK2:IL-23R:Jak2 e29:IL-12Rbeta1:TYK2 e3: e30:IL-12Rbeta2:JAk2 e31:IL-23R:Jak2 e32:IL-12Rbeta2:JAk2:IL-12B e33:IL-12Rbeta2{p}:JAk2{p}:IL-12B e34:IL-12Rbeta2{p}:JAk2{p}:IL-12B:stat4 e35:IL-12Rbeta2{p}:JAk2{p}:IL-12B:stat4{p} e36:(Stat4{p})2 e37:(Stat4{p})2 e38:IFN-gamma e39:IFN-gamma:(Stat4{p})2 e4: e40:IFN-gamma e41:IL-23:IL-12betaR1:TYK2:IL-23R:Jak2{p} e42:IL-23:IL-12betaR1:TYK2:IL-23R{p}:Jak2{p} e43:IL-23:IL-12betaR1:TYK2:IL-23R{p}:Jak2{p}:stat3 e44:IL-23:IL-12betaR1:TYK2:IL-23R{p}:Jak2{p}:stat3{p} e45:(stat3{p})2 e46:(stat3{p})2 e47:IFN-gamma:(stat3{p})2 e48:IL-17 e49:IL-17:(stat3{p})2 e5:Il-12 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:type I interferon e60: e61: e62: e63:IL-17 e64:MKK3{p} e65:p38{p} e66:IL-27 e67:SB203850 e68:SPHk2 e69:sphingosine 1-phosphate e7: e70:IL12Rbeta1:SPHK2 e71:PI3K e72:AKT{active} e73:p50{active} e74:RelB{active} e75:PIASx e76:STAT4:PIASx e77:STAT3{active} e78:STAT1 e79:STAT6{active} e8: e80:STAT5{active} e81:STAT4{active} e82:TCR:TCR ligand e83:Stat4 e84:IL-18R e85:type I IFNs e86:type I IFNs e87:IL-2R:(stat4{p})2:CBP:c-jun e88:IL-2R e89:IL-2R e9: e90:IFN-gamma:T-bet e91:IFN-gamma:Stat5

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p8 p9
Model Detail
1166.0, 806.0
28.0, 28.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p38 p45

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
1232.0, 364.0
24.0, 24.0

PI3K{active}

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46

p47

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1092.0, 424.0
32.0, 32.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
1107.0, 1731.0
25.0, 25.0

c-Jun

--

MO000000049

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p70

true true true true

csml-variable:Double

m94

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
1135.0, 1623.0
26.0, 26.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1506.0, 770.0
36.0, 36.0

Lck

--

MO000000138

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p34

true true true true

csml-variable:Double

m123

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000138

--

Go back
1631.0, 1287.0
26.0, 26.0

Jak2

--

MO000000146

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12

true true true true

csml-variable:Double

m130

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000146

--

Go back
1639.0, 927.0
26.0, 26.0

Tyk2

--

MO000000148

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m132

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000148

--

Go back
1115.0, 1655.0
26.0, 26.0

c-Rel

--

MO000000192

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m165

10

false

infinite

0

unit false false false
TRANSPATHMO000000192

--

Go back
1536.0, 1196.0
31.0, 31.0

RelB

--

MO000000194

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m167

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000194

--

Go back
1103.0, 1031.0
26.0, 26.0

p50

--

MO000000200

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m172

10

false

infinite

0

unit false false false
TRANSPATHMO000000200

--

Go back
1831.0, 1511.0
18.0, 18.0

IL-13

--

MO000007321

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m836

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000007321

--

Go back
1216.0, 1624.0
32.0, 32.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
1073.0, 537.0
30.0, 30.0

STAT1{active}

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53 p56

--

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
1516.0, 672.0
24.0, 24.0

STAT3

--

MO000013122

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p52

true true true true

csml-variable:Double

m1360

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
871.0, 911.0
34.0, 34.0

STAT6

--

MO000013130

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m1368

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013130

--

Go back
696.0, 692.0
32.0, 32.0

STAT5

--

MO000016876

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55 p57

true true true true

csml-variable:Double

m1798

10

false

infinite

0

unit false false false
TRANSPATHMO000016876

--

Go back
294.0, 1622.0
36.0, 36.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65 p66

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1809.0, 1461.0
22.0, 22.0

IL-11

--

MO000016949

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m1859

10

false

infinite

0

unit false false false
TRANSPATHMO000016949

--

Go back
1360.0, 516.0
32.0, 32.0

MKK3

--

MO000016966

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m1875

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
1801.0, 1325.0
30.0, 30.0

IL-4

--

MO000017053

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m1947

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000017053

--

Go back
1229.0, 117.0
30.0, 30.0

IL-2

--

MO000017061

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46 p59

true true true true

csml-variable:Double

m1954

10

false

infinite

0

unit false false false
TRANSPATHMO000017061

--

Go back
292.0, 1096.0
32.0, 32.0

IL-15

--

MO000017063

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m1956

10

false

infinite

0

unit false false false
InterProIPR003443
TRANSPATHMO000017063

--

Go back
1388.0, 924.0
32.0, 32.0

SOCS-3

--

MO000017121

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m2005

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017121

--

Go back
1506.0, 1082.0
28.0, 28.0

STAT4

--

MO000017181

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p41 p51 p58 p59 p60 p61 p62 p67

true true true true

csml-variable:Double

m2053

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000017181

--

Go back
1788.0, 1428.0
24.0, 24.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
1903.0, 1611.0
26.0, 26.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1 p2

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
947.0, 1719.0
34.0, 34.0

CBP

--

MO000017462

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p70

true true true true

csml-variable:Double

m2282

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000017462

--

Go back
1251.0, 591.0
25.0, 25.0

MKK6

--

MO000019005

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m3613

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
314.0, 1410.0
28.0, 28.0

IL-21

--

MO000019512

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m4065

10

false

infinite

0

unit false false false
TRANSPATHMO000019512

--

Go back
1586.0, 734.0
28.0, 28.0

STAT3{p}

--

MO000021607

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

p27

true true true true

csml-variable:Double

m5950

10

false

infinite

0

unit false false false
TRANSPATHMO000021607

--

Go back
1360.0, 1008.0
32.0, 32.0

STAT4{pY}

--

MO000033720

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p41

p18

true true true true

csml-variable:Double

m12383

10

false

infinite

0

unit false false false
TRANSPATHMO000033720

--

Go back
1692.0, 908.0
24.0, 24.0

IL-12Rbeta1

--

MO000034025

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p44

true true true true

csml-variable:Double

m12587

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000034025

--

Go back
1707.0, 1307.0
26.0, 26.0

IL-12Rbeta2

--

MO000034026

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m12588

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000034026

--

Go back
970.0, 734.0
28.0, 28.0

sphingosine

--

MO000034420

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m356991

10

false

infinite

0

unit false false false
TRANSPATHMO000034420

--

Go back
1256.0, 716.0
24.0, 24.0

MKK6{p}

--

MO000038355

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

p37

true true true true

csml-variable:Double

m16567

10

false

infinite

0

unit false false false
TRANSPATHMO000038355

--

Go back
1386.0, 854.0
28.0, 28.0

Lck{p}

--

MO000038421

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33 p34

--

true true true true

csml-variable:Double

m16631

10

false

infinite

0

unit false false false
TRANSPATHMO000038421

--

Go back
1906.0, 1006.0
19.0, 19.0

IL-12A

--

MO000043605

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m21349

10

false

infinite

0

unit false false false
TRANSPATHMO000043605

--

Go back
1947.0, 1215.0
25.0, 25.0

IL-12B

--

MO000043607

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m21351

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000043607

--

Go back
1376.0, 1216.0
32.0, 32.0

T-bet

--

MO000090987

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

p8 p72

true true true true

csml-variable:Double

m64461

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000090987

--

Go back
381.7468628731279, 184.52690265257155
1387.6516464431181, 2014.8701906354063

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
423.11678986759773, 206.3232605419409
1345.0593810837568, 1892.1203392412308

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1733.5, 1571.0879193159394
21.137908353431264, 40.91208068406052

MCP1:MCP1 receptor

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1729.5, 1663.2852444639336
21.035957026967772, 40.714755536066654

prostaglandin E2:prostaglandin E2 receptor

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1734.5, 1725.6395527296645
18.786231089673315, 36.360447270335456

histamine:histamine receptor

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1733.5, 1767.3904845428635
20.981582986187238, 40.609515457136595

FcR crosslinking

--

e14

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1725.5, 1848.6139004604254
20.34948476211357, 39.38609953957465

CCR5 receptor: CCR5 ligand

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1859.0, 1768.5517241379312
41.37931034482758, 23.448275862068964

cholera toxin

--

e16

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1033.0, 1689.9210665959142
53.441231095781376, 11.578933404085964

IL12-p40

--

e17

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p3

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1284.0, 1689.0582411931089
47.44150167138081, 13.441758806891231

IL12-p40:transcription factors

--

e18

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p3

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1231.0, 1674.4199999999998
25.439999999999994, 19.080000000000002

ICSBP

--

e19

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p3

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
381.7468628731279, 184.52690265257155
1387.6516464431181, 2014.8701906354063

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1174.0, 1622.98
35.36, 26.52

Ets

--

e20

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p3

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1696.5, 999.7131583776841
23.855569829326484, 33.286841622316025

IL-12Rbeta1:TYK2:IL-12A

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1706.5, 1167.5090842356399
18.268489631124982, 25.490915764360437

IL-12Rbeta2:JAk2{p}:IL-12B

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p14

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
325.0, 1287.0196445275963
16.891487371375117, 38.980355472404106

IFN-gamma

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

p40 p68

p6 p7

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1171.0, 1328.1626297577855
42.82006920415225, 22.837370242214533

TBX21

--

e24

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p7

p6

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1340.0, 1355.7820069204151
32.28373702422145, 17.21799307958478

IL12Rbeta2

--

e25

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p8

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1708.5, 862.2704769571342
22.03320587643389, 35.72952304286577

IL-23R

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1951.0, 880.7267135325131
33.49736379613357, 21.77328646748682

IL-23

--

e27

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p9

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1710.0, 766.5882352941177
20.64705882352941, 34.41176470588236

IL-23:IL-12betaR1:TYK2:IL-23R:Jak2

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p22

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
1696.5, 961.2447925345778
23.483419430094983, 28.755207465422437

IL-12Rbeta1:TYK2

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p4 p9

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
409.49989580199014, 212.27993558143388
1332.145580585393, 1959.364124777684

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1713.5, 1259.7542076320615
20.617397100483256, 25.245792367938687

IL-12Rbeta2:JAk2

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p5

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1708.5, 822.1846358940177
22.715880686552236, 27.815364105982333

IL-23R:Jak2

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p9

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1713.5, 1213.492016883832
20.430721233253802, 28.507983116168116

IL-12Rbeta2:JAk2:IL-12B

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p13

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1706.5, 1130.4079647641772
19.05762525233988, 26.592035235823086

IL-12Rbeta2{p}:JAk2{p}:IL-12B

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14 p17

p15 p33 p34 p35 p36 p49 p50 p52 p53 p54 p55 p64

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1705.0, 1081.3529411764707
22.588235294117645, 37.64705882352941

IL-12Rbeta2{p}:JAk2{p}:IL-12B:stat4

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p16

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1701.0, 1041.7941176470588
22.323529411764707, 37.205882352941174

IL-12Rbeta2{p}:JAk2{p}:IL-12B:stat4{p}

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p17

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1488.0, 1187.1436464088397
23.270718232044203, 25.856353591160232

(Stat4{p})2

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1352.0, 1387.1436464088397
23.270718232044203, 25.856353591160232

(Stat4{p})2

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p20 p70

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1274.0, 1424.424276169265
43.073496659242764, 15.075723830734967

IFN-gamma

--

e38

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p20 p29 p72 p69

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
1406.0, 1495.5
60.0, 17.0

IFN-gamma:(Stat4{p})2

--

e39

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p20

p21

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
460.8430067203859, 260.8477432069429
1229.4593587486024, 1862.2285095266645

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1120.0, 1573.2975778546715
40.692041522491344, 21.702422145328722

IFN-gamma

--

e40

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p21 p30 p39 p73

p40 p68

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1702.0, 711.9117647058825
19.85294117647059, 33.08823529411766

IL-23:IL-12betaR1:TYK2:IL-23R:Jak2{p}

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p23

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1701.0, 665.6764705882352
21.794117647058826, 36.32352941176471

IL-23:IL-12betaR1:TYK2:IL-23R{p}:Jak2{p}

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23 p26

p24 p56 p57 p58

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1703.0, 601.4411764705883
26.735294117647058, 44.55882352941177

IL-23:IL-12betaR1:TYK2:IL-23R{p}:Jak2{p}:stat3

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p25

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1705.0, 537.6764705882354
21.794117647058826, 36.3235294117647

IL-23:IL-12betaR1:TYK2:IL-23R{p}:Jak2{p}:stat3{p}

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p26

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1587.5, 848.6850524912516
24.757207132144636, 30.31494750874854

(stat3{p})2

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

p28

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1156.5, 1454.194634227629
22.707715380769866, 27.805365772371267

(stat3{p})2

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

p29 p32

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1351.0, 1525.1227822062228
50.74312162509642, 14.377217793777321

IFN-gamma:(stat3{p})2

--

e47

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p29

p30

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
889.0, 1435.5017301038065
45.93425605536333, 24.49826989619377

IL-17

--

e48

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p31

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1117.0, 1372.0736693237336
54.44587297505785, 15.426330676266394

IL-17:(stat3{p})2

--

e49

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p32

p31

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1264.0, 1613.242214532872
40.79584775086505, 21.757785467128027

Il-12

--

e5

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p1 p2

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
689.4801074486085, 1244.5001141346895
836.6580285714346, 758.7569085927178

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
779.8454066239218, 1262.4815498092946
489.21903346635133, 735.3865725991018

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
700.3862642456291, 1254.6272597319237
814.8457149773944, 738.50261739825

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
701.9442866452034, 1256.1852821314967
811.7296701782448, 735.3865725991018

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
689.4801074486085, 1244.5001141346895
836.6580285714346, 758.7569085927178

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
689.4801074486085, 1244.5001141346895
836.6580285714346, 758.7569085927178

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
701.9442866452034, 1256.1852821314967
811.7296701782448, 735.3865725991018

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
1300.2248880817592, 1556.1045940495624
52.26979660419682, 47.317921136430904

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
1163.1189169192166, 1774.2277299899781
148.01212795956485, 133.9899263633957

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
689.4801074486085, 1244.5001141346895
836.6580285714346, 758.7569085927178

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1813.0, 1652.0073455423626
38.0961964177903, 23.492654457637354

type I interferon

--

e6

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
886.6756972321964, 1581.6854146533437
26.49573042501896, 12.757203537972115

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
885.7909297949784, 1543.6404148529696
90.6886623148475, 163.23959216672563

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
923.8359295953545, 1649.8125073191347
14.156278995488385, 14.156278995488396

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1229.6824091270894, 1310.728442557708
45.09949588750332, 9.771557442292385

IL-17

--

e63

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p32

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1359.0, 678.4634146341463
33.170731707317074, 26.536585365853657

MKK3{p}

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

p35

p38

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1165.0, 984.292682926829
29.634146341463417, 23.70731707317073

p38{p}

--

e65

cso30:c:Protein

cso30:i:CC_Cytosol

--

p37 p38 p45

p39 p40 p41

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
290.0, 1201.74
27.68, 20.76000000000001

IL-27

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p62

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1554.0, 1399.5937762825904
43.069806560134566, 24.406223717409585

SB203850

--

e67

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p39 p40

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1072.5, 614.2342523646605
22.05554437512578, 35.76574763533911

SPHk2

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p42 p44

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1064.0, 815.1463414634146
32.3170731707317, 25.853658536585364

sphingosine 1-phosphate

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

p42

p43 p45

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
407.97858150195043, 183.6348995816281
1360.8539441350024, 1928.2948876304108

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1702.0, 475.95580110497235
28.83977900552486, 32.04419889502763

IL12Rbeta1:SPHK2

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1076.0, 336.0
24.0, 24.0

PI3K

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1272.0, 448.0
32.0, 32.0

AKT{active}

--

e72

cso30:c:Protein

cso30:i:CC_CellComponent

--

p47

p48

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
955.0, 1071.0
26.0, 26.0

p50{active}

--

e73

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

--

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
TRANSPATHMO000000200

--

Go back
1548.0, 1304.0
31.0, 31.0

RelB{active}

--

e74

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

--

true true true true

csml-variable:Double

m78

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000194

--

Go back
1319.0, 862.0600000000002
25.91999999999999, 19.439999999999994

PIASx

--

e75

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p51

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
1283.0, 897.8232044198894
25.359116022099446, 28.176795580110497

STAT4:PIASx

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1484.0, 496.0
24.0, 24.0

STAT3{active}

--

e77

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

--

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
777.0, 537.0
30.0, 30.0

STAT1

--

e78

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53 p56

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
871.0, 1075.0
34.0, 34.0

STAT6{active}

--

e79

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54

--

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013130

--

Go back
430.8403731363035, 218.66744102209748
1305.4834042318141, 1895.5619029445943

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
700.0, 824.0
32.0, 32.0

STAT5{active}

--

e80

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55 p57

p69

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
TRANSPATHMO000016876

--

Go back
702.0, 1194.0
28.0, 28.0

STAT4{active}

--

e81

cso30:c:Protein

cso30:i:CC_CellComponent

--

p58 p59 p60 p61 p62 p67

p68

true true true true

csml-variable:Double

m85

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000017181

--

Go back
418.5, 1492.9688664766497
19.64941898706424, 38.03113352335015

TCR:TCR ligand

--

e82

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p63

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
902.0, 1496.4429065743946
44.16955017301038, 23.557093425605537

Stat4

--

e83

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p63

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
1417.0, 1769.9031141868513
37.681660899653984, 20.096885813148795

IL-18R

--

e84

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p64

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
847.0, 1632.1626297577857
42.82006920415225, 22.837370242214536

type I IFNs

--

e85

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p65

p66

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
290.0, 1525.733395696913
19.615528531337695, 45.266604303087

type I IFNs

--

e86

cso30:c:Protein

cso30:i:CC_Cytosol

--

p66

p67

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
1110.0, 1791.5
60.0, 17.0

IL-2R:(stat4{p})2:CBP:c-jun

--

e87

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p70

p71

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
890.0, 1793.5
60.0, 13.0

IL-2R

--

e88

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p70

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
1032.0, 1905.8512110726645
39.65397923875433, 21.148788927335644

IL-2R

--

e89

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p71

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
443.80515082791084, 252.69998246256716
1299.5231563889495, 1870.702083572312

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
902.0, 1371.5
60.0, 17.0

IFN-gamma:T-bet

--

e90

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p72

p73

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
970.0, 1627.5
60.0, 17.0

IFN-gamma:Stat5

--

e91

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p69

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1557.0, 1613.0
21.0, 21.0

p1

p1

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e5 MO000017247 MO000016949 MO000007321 e11 e6 e12 e13 e14 e16

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c3 : 1
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c14 : 1
stoichiometry:c2 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 15546391, 7836910, 9000540, 10993913, 9548515, 11859138, 8760828, 8557999, 11207258 IL-12 production is inhibited by other cytokines including IL-10, IL-11, IL-13 and type I interferons (IFNs) PMID: 15546391, 12009566 G-protein-coupled receptors (GPCRs), including the receptors for monocyte chemoattractant protein 1 (MCP-1), prostaglandin E2, histamine, and FcR cross-linking, also inhibit IL-12 production, although some GPCRs like CCR5 positively regulate production PMID: 15546391, 11169439, 9294136 Cholera toxin and measles virus also downregulate IL-12 production

Go back
1859.0, 930.5
18.5, 18.5

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000034025 MO000000148

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m12587*m132*0.1

nodelay

--

true

0

false

PMID: 15546391, 12023369, 7528775, 9038232 IL-12Rb1 binds the Janus kinase (Jak) family member Tyk2, whereas IL-12Rb2 and IL-23R associate with Jak2.

Go back
1866.0, 1290.0
19.0, 19.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000146 MO000034026

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m130*m12588*0.1

nodelay

--

true

0

false

PMID: 15546391, 12023369, 7528775, 9038232 IL-12Rb1 binds the Janus kinase (Jak) family member Tyk2, whereas IL-12Rb2 and IL-23R associate with Jak2.

Go back
1863.0, 826.5
18.5, 18.5

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 MO000000146

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m27*m130*0.1

nodelay

--

true

0

false

PMID: 15546391, 12023369, 7528775, 9038232 IL-12Rb1 binds the Janus kinase (Jak) family member Tyk2, whereas IL-12Rb2 and IL-23R associate with Jak2.

Go back
1819.0, 1170.5
18.5, 18.5

p13

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e32

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 15546391 Ligand binding brings the receptor chains and associated Jaks (Jak2 and Tyk2) in close proximity, resulting in Jak transphosphorylation and subsequent phosphorylation of the receptor chains by activated Jaks.

Go back
1825.0, 1133.0
21.0, 21.0

p14

p14

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e22

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 15546391 Ligand binding brings the receptor chains and associated Jaks (Jak2 and Tyk2) in close proximity, resulting in Jak transphosphorylation and subsequent phosphorylation of the receptor chains by activated Jaks.

Go back
1603.0, 1091.0
17.0, 17.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e33 MO000017181 MO000017121

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c147 : 1
stoichiometry:c55 : 1

m34*m2053*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-12Rb2 is phosphorylated and serves as a docking site for STAT4. STAT4 binds to the receptor chain and is itself phosphorylated. PMID: 15546391, 14559241 SOCS-3 has been reported to be a negative regulator of IL-12 signaling by preventing STAT4 binding to the IL-12Rb2 subunit

Go back
1821.0, 1089.0
21.0, 21.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-12Rb2 is phosphorylated and serves as a docking site for STAT4. STAT4 binds to the receptor chain and is itself phosphorylated.

Go back
1561.0, 1013.0
21.0, 21.0

p17

p17

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e35

MO000033720 e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 15546391 From figure 1.

Go back
1353.0, 1165.0
21.0, 21.0

p18

p18

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000033720

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m12383*0.1

nodelay

--

true

0

false

PMID: 15546391 From figure 1.

Go back
1489.0, 1289.0
21.0, 21.0

p19

p19

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 15546391 STAT4 homodimers shuttle into the nucleus where they bind to STATbinding sites in the interferon IFN-gamma promoter and, through mechanisms that are not entirely clear, induce transcription of the IFN-g gene

Go back
1554.0, 1670.0
20.0, 20.0

p2

p2

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e5 e15

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c13 : 1
stoichiometry:c12 : 1

m5*m15*0.1

nodelay

--

true

0

false

PMID: 15546391, 12009566 G-protein-coupled receptors (GPCRs), including the receptors for monocyte chemoattractant protein 1 (MCP-1), prostaglandin E2, histamine, and FcR cross-linking, also inhibit IL-12 production, although some GPCRs like CCR5 positively regulate production.

Go back
1427.0, 1439.0
17.0, 17.0

p20

p20

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e37 e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m38*m39*0.1

nodelay

--

true

0

false

PMID: 15546391 STAT4 homodimers shuttle into the nucleus where they bind to STATbinding sites in the interferon IFN-gamma promoter and, through mechanisms that are not entirely clear, induce transcription of the IFN-g gene. PMID: 15546391 Using chromatin immunoprecipitation assay, the binding of STAT4 to the IFNG gene has now been documented. PMID: 15546391, 12242445, 9558063, 15280353 In both mouse (90) and human (193, 264), STAT4 has been shown to interact with the IFNG gene in the promoter/introns.

Go back
1425.0, 1565.0
21.0, 21.0

p21

p21

cso30:i:ME_Transcription

cso30:i:CC_Cytosol

--

e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 15546391 STAT4 homodimers shuttle into the nucleus where they bind to STATbinding sites in the interferon IFN-gamma promoter and, through mechanisms that are not entirely clear, induce transcription of the IFN-g gene

Go back
1813.0, 745.0
21.0, 21.0

p22

p22

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e28

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 stimulation also activates the Jaks and STATs, but STAT3, and not STAT4, appears to be the predominant STAT activated.

Go back
1825.0, 673.0
21.0, 21.0

p23

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 stimulation also activates the Jaks and STATs, but STAT3, and not STAT4, appears to be the predominant STAT activated.

Go back
1618.0, 674.0
19.0, 19.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 MO000013122

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m43*m1360*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 stimulation also activates the Jaks and STATs, but STAT3, and not STAT4, appears to be the predominant STAT activated.

Go back
1817.0, 613.0
21.0, 21.0

p25

p25

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 stimulation also activates the Jaks and STATs, but STAT3, and not STAT4, appears to be the predominant STAT activated.

Go back
1588.0, 544.0
23.0, 23.0

p26

p26

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e44

MO000021607 e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 stimulation also activates the Jaks and STATs, but STAT3, and not STAT4, appears to be the predominant STAT activated.

Go back
1589.0, 792.5
22.5, 22.5

p27

p27

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000021607

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m5950*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 stimulation also activates the Jaks and STATs, but STAT3, and not STAT4, appears to be the predominant STAT activated.

Go back
1489.0, 933.0
21.0, 21.0

p28

p28

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 stimulation also activates the Jaks and STATs, but STAT3, and not STAT4, appears to be the predominant STAT activated.

Go back
1365.0, 1477.0
21.0, 21.0

p29

p29

cso30:i:ME_DNABinding

cso30:i:CC_Cytosol

--

e46 e38

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m47*m39*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 induces IFN-g production as well as the production of the proinflammatory cytokine IL-17.

Go back
1181.0, 1685.0
21.0, 21.0

p3

p3

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e17 MO000007685 MO000000058 MO000000192 e19 e20

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c16 : 1

m17*m970*m19*m165*m20*m21*0.1

nodelay

--

true

0

false

PMID: 15546391, 8551218, 7565674, 9099678, 9234715, 10861061, 11058167, 9497375, 12876285 Several transcription factors have been shown to bind to the mouse and human p40 promoters including nuclear factor (NF)-kB, IFN-regulatory factor (IRF)-1, c-Rel, IFN consensus binding protein (ICSBP, also called IRF-8), and Ets family members

Go back
1362.0, 1598.0
19.0, 19.0

p30

p30

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e47

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 induces IFN-g production as well as the production of the proinflammatory cytokine IL-17.

Go back
1133.0, 1497.0
21.0, 21.0

p31

p31

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e49

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c91 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 induces IFN-g production as well as the production of the proinflammatory cytokine IL-17.

Go back
1258.0, 1374.0
19.0, 19.0

p32

p32

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e46 e63

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m47*m64*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 induces IFN-g production as well as the production of the proinflammatory cytokine IL-17.

Go back
1455.0, 858.5
18.5, 18.5

p33

p33

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000138 e33

MO000038421

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c98 : 1
stoichiometry:c97 : 1

m123*m34*0.1

nodelay

--

true

0

false

PMID: 15546391, 7553885 In NK cells, the Src family protein tyrosine kinase Lck is tyrosine phosphorylated in response to IL-12 signaling in both resting and activated cells, and IL-12 stimulation also increased in vitro Lck autophosphorylation

Go back
1404.0, 776.0
23.0, 23.0

p34

p34

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

MO000000138 e33

MO000038421

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c101 : 1
stoichiometry:c100 : 1

m123*m34*0.1

nodelay

--

true

0

false

PMID: 15546391, 7553885 In NK cells, the Src family protein tyrosine kinase Lck is tyrosine phosphorylated in response to IL-12 signaling in both resting and activated cells, and IL-12 stimulation also increased in vitro Lck autophosphorylation

Go back
1366.0, 598.0
19.0, 19.0

p35

p35

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016966 e33

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c104 : 1
stoichiometry:c103 : 1

m1875*m34*0.1

nodelay

--

true

0

false

PMID: 15546391, 10961885, 10201984, 10903740 IL-12 evidently does not activate p42/44 ERK or JNK; however, both p38 MAPK and its upstream activator MKK3/6 are activated in response to IL-12 signaling

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1259.0, 655.0
17.0, 17.0

p36

p36

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000019005 e33

MO000038355

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c107 : 1
stoichiometry:c106 : 1

m3613*m34*0.1

nodelay

--

true

0

false

PMID: 15546391, 10961885, 10201984, 10903740 IL-12 evidently does not activate p42/44 ERK or JNK; however, both p38 MAPK and its upstream activator MKK3/6 are activated in response to IL-12 signaling

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1171.0, 907.0
17.0, 17.0

p37

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 MO000038355

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c113 : 1
stoichiometry:c109 : 1

m66*m16567*0.1

nodelay

--

true

0

false

PMID: 15546391, 10961885, 10201984, 10903740 IL-12 evidently does not activate p42/44 ERK or JNK; however, both p38 MAPK and its upstream activator MKK3/6 are activated in response to IL-12 signaling

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1221.0, 905.5
16.5, 16.5

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c112 : 1
stoichiometry:c111 : 1

m66*m65*0.1

nodelay

--

true

0

false

PMID: 15546391, 10961885, 10201984, 10903740 IL-12 evidently does not activate p42/44 ERK or JNK; however, both p38 MAPK and its upstream activator MKK3/6 are activated in response to IL-12 signaling

Go back
1233.0, 1485.0
21.0, 21.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e65 e67

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c120 : 1
stoichiometry:c115 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 15546391, 10903740 Moreover, activation of p38 MAPK is required for IFN-g production in response to IL-12 stimulation.

Go back
1827.0, 1007.0
17.0, 17.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000043605 e29

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c22 : 1
stoichiometry:c24 : 1

m21349*m30*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-12p40 interacts predominantly with the beta1 subunit, whereas p35 interacts largely with the beta2 subunit.

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1565.0, 1493.0
21.0, 21.0

p40

p40

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e40 e65 e67

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c117 : 1

m41*m67*0.1

nodelay

--

true

0

false

PMID: 15546391, 10903740 Moreover, activation of p38 MAPK is required for IFN-g production in response to IL-12 stimulation. PMID: 15546391, 9582275 The IFN-g production is blocked by the p38 MAPK inhibitor SB203850 or expression of a dominant negative p38 transgene

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1398.0, 1062.0
19.0, 19.0

p41

p41

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017181 e65

MO000033720

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c123 : 1
stoichiometry:c122 : 1

m2053*m67*0.1

nodelay

--

true

0

false

PMID: 15546391, 10903740, 10961885 p38 MAPK mediates STAT4 serine phosphorylation in response to IL-12 stimulation

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1070.0, 738.0
19.0, 19.0

p42

p42

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000034420 e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c126 : 1
stoichiometry:c125 : 1

m356991*m70*0.1

nodelay

--

true

0

false

PMID: 15546391, 12011102 Sphingosine kinase 2 (SPHK2) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P), and the latter has been suggested to be an important intracellular messenger that promotes cell proliferation and survival

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954.0, 818.0
19.0, 19.0

p43

p43

cso30:i:CE_CellProliferation

cso30:i:CC_Cytosol

--

e69

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 15546391, 12011102 Sphingosine kinase 2 (SPHK2) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P), and the latter has been suggested to be an important intracellular messenger that promotes cell proliferation and survival

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1154.0, 710.0
19.0, 19.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e68 MO000034025

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m70*m12587*0.1

nodelay

--

true

0

false

PMID: 15546391, 12874225 Using yeast two-hybrid studies, it was reported that SPHK2 associates with IL-12Rb1, and expression of SPHK2 in a T-cell clone augmented IL-12- induced STAT4 transcriptional activation and IFN-g production,while having no effect on proliferation

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1121.0, 909.0
21.0, 21.0

p45

p45

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 e69

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c133 : 1
stoichiometry:c132 : 1

m66*m71*0.1

nodelay

--

true

0

false

PMID: 15546391, 11415936 S1P has been reported to activate p38 MAPK in endothelial cells

Go back
1153.0, 365.0
21.0, 21.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e71 MO000017061

MO000000030

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c139 : 1
stoichiometry:c135 : 1

m74*m1954*0.1

nodelay

--

true

0

false

PMID: 15546391, 9390691 The phosphatidylinositol 3-kinase (PI3K)/Akt-signaling pathway is activated by numerous cytokines, including IL-2, contributing to cell proliferation and antagonizing apoptosis

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1190.0, 454.5
19.5, 19.5

p47

p47

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000048 MO000000030

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c138 : 1
stoichiometry:c137 : 1

m75*m73*0.1

nodelay

--

true

0

false

PMID: 15546391, 9390691 The phosphatidylinositol 3-kinase (PI3K)/Akt-signaling pathway is activated by numerous cytokines, including IL-2, contributing to cell proliferation and antagonizing apoptosis

Go back
1417.0, 453.0
21.0, 21.0

p48

p48

cso30:i:CE_CellProliferation

cso30:i:CC_Cytosol

--

e72

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 15546391, 9390691 The phosphatidylinositol 3-kinase (PI3K)/Akt-signaling pathway is activated by numerous cytokines, including IL-2, contributing to cell proliferation and antagonizing apoptosis

Go back
1035.0, 1075.0
17.0, 17.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000200 e33

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c143 : 1
stoichiometry:c142 : 1

m172*m34*0.1

nodelay

--

true

0

false

PMID: 15546391, 9768751 In DCs, IL-12 activates p50 and RelB NF-kB transcription factors

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1838.0, 1218.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000043607 e30

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c25 : 1
stoichiometry:c27 : 1

m21351*m31*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-12p40 interacts predominantly with the beta1 subunit, whereas p35 interacts largely with the beta2 subunit.

Go back
1555.0, 1255.0
17.0, 17.0

p50

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000194 e33

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c146 : 1
stoichiometry:c145 : 1

m167*m34*0.1

nodelay

--

true

0

false

PMID: 15546391, 9768751 In DCs, IL-12 activates p50 and RelB NF-kB transcription factors

Go back
1329.0, 953.0
21.0, 21.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017181 e75

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1

m2053*m79*0.1

nodelay

--

true

0

false

PMID: 15546391, 12716907 PIASx was shown to inhibit IL-12 signaling by binding to STAT4 and preventing STAT4-dependent gene transcription.

Go back
1487.0, 622.5
18.5, 18.5

p52

p52

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013122 e33

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c153 : 1
stoichiometry:c152 : 1

m1360*m34*0.1

nodelay

--

true

0

false

PMID: 15546391, 7722452, 8683106, 10201984, 9531298 They include STAT1 (81, 82), STAT3 (12), STAT5 (82), and under certain conditions, STAT6 (83).

Go back
937.0, 541.0
21.0, 21.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e78 e33

MO000013119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c156 : 1
stoichiometry:c155 : 1

m82*m34*0.1

nodelay

--

true

0

false

PMID: 15546391, 7722452, 8683106, 10201984, 9531298 They include STAT1 (81, 82), STAT3 (12), STAT5 (82), and under certain conditions, STAT6 (83).

Go back
877.0, 989.0
21.0, 21.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013130 e33

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c159 : 1
stoichiometry:c158 : 1

m1368*m34*0.1

nodelay

--

true

0

false

PMID: 15546391, 7722452, 8683106, 10201984, 9531298 They include STAT1 (81, 82), STAT3 (12), STAT5 (82), and under certain conditions, STAT6 (83).

Go back
721.0, 761.0
21.0, 21.0

p55

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016876 e33

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c162 : 1
stoichiometry:c161 : 1

m1798*m34*0.1

nodelay

--

true

0

false

PMID: 15546391, 7722452, 8683106, 10201984, 9531298 They include STAT1 (81, 82), STAT3 (12), STAT5 (82), and under certain conditions, STAT6 (83).

Go back
921.0, 453.0
21.0, 21.0

p56

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e78 e42

MO000013119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c165 : 1
stoichiometry:c164 : 1

m82*m43*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 stimulation results in the activation of STAT1, STAT3, STAT4, and STAT5.

Go back
653.0, 753.0
21.0, 21.0

p57

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016876 e42

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c168 : 1
stoichiometry:c167 : 1

m1798*m43*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 stimulation results in the activation of STAT1, STAT3, STAT4, and STAT5.

Go back
1009.0, 1141.0
21.0, 21.0

p58

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017181 e42

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c171 : 1
stoichiometry:c170 : 1

m2053*m43*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 stimulation results in the activation of STAT1, STAT3, STAT4, and STAT5.

Go back
1125.0, 1197.0
21.0, 21.0

p59

p59

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017181 MO000017061

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c174 : 1
stoichiometry:c173 : 1

m2053*m1954*0.1

nodelay

--

true

0

false

PMID: 15546391, 9886399, 12759422 Moreover, IL-2, IL-15, and IL-21 have all been reported to activate STAT4

Go back
1290.0, 1222.0
19.0, 19.0

p6

p6

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e24 e23

MO000090987

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c32 : 1
stoichiometry:c29 : 1

m25*m24*0.1

nodelay

--

true

0

false

--

Go back
808.0, 1104.0
15.0, 15.0

p60

p60

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017181 MO000017063

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c177 : 1
stoichiometry:c176 : 1

m2053*m1956*0.1

nodelay

--

true

0

false

PMID: 15546391, 9886399, 12759422 Moreover, IL-2, IL-15, and IL-21 have all been reported to activate STAT4

Go back
1055.0, 1169.5
18.5, 18.5

p61

p61

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019512 MO000017181

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c178 : 1

m4065*m2053*0.1

nodelay

--

true

0

false

PMID: 15546391, 9886399, 12759422 Moreover, IL-2, IL-15, and IL-21 have all been reported to activate STAT4

Go back
871.0, 1135.0
17.0, 17.0

p62

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017181 e66

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c183 : 1
stoichiometry:c181 : 1

m2053*m68*0.1

nodelay

--

true

0

false

PMID: 15546391, 14657353 The dimeric cytokine IL-27 also triggers STAT4 activation

Go back
845.0, 1497.0
21.0, 21.0

p63

p63

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e82

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c184 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 15546391, 7638186 While STAT4 expression is very low in resting T cells, it is upregulated by T-cell receptor (TCR) stimulation.

Go back
1426.0, 1698.0
19.0, 19.0

p64

p64

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c186 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 15546391, 11120802 IL-12 also enhances the expression of the IL-18 receptor

Go back
749.0, 1673.0
21.0, 21.0

p65

p65

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000016882

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 15546391, 11896392 The authors attribute this to the fact that LPS induces type I IFNs that activate STAT4 and induce IFN-g

Go back
601.0, 1612.0
23.0, 23.0

p66

p66

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e85 MO000016882

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c192 : 1
stoichiometry:c191 : 1

m89*m155666*0.1

nodelay

--

true

0

false

PMID: 15546391, 11896392 The authors attribute this to the fact that LPS induces type I IFNs that activate STAT4 and induce IFN-g

Go back
966.0, 1230.0
19.0, 19.0

p67

p67

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017181 e86

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c195 : 1
stoichiometry:c194 : 1

m2053*m90*0.1

nodelay

--

true

0

false

PMID: 15546391, 11896392 The authors attribute this to the fact that LPS induces type I IFNs that activate STAT4 and induce IFN-g

Go back
701.0, 1389.0
21.0, 21.0

p68

p68

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e40 e81

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c198 : 1
stoichiometry:c197 : 1

m41*m85*0.1

nodelay

--

true

0

false

PMID: 15546391, 11896392 The authors attribute this to the fact that LPS induces type I IFNs that activate STAT4 and induce IFN-g

Go back
997.0, 1565.0
22.0, 22.0

p69

p69

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e38 e80

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c212 : 1
stoichiometry:c213 : 1

m39*m84*0.1

nodelay

--

true

0

false

PMID: 15546391 We have identified an STAT5-binding element 3.6 Kb upstream that seems to be required for IL-2-enhancement of IFN-g expression

Go back
1110.0, 1290.0
19.0, 19.0

p7

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c30 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 15546391, 11752460, 12006974 In Th1 cells, IFN-g stimulation upregulates the transcription factor T-bet, which in turn promotes IL-12Rb2 chain expression

Go back
1001.0, 1790.0
21.0, 21.0

p70

p70

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e88 e37 MO000017462 MO000000049

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c207 : 1
stoichiometry:c202 : 1

m92*m38*m2282*m94*0.1

nodelay

--

true

0

false

PMID: 15546391 In addition, it was demonstrated that IL-12 induces binding of STAT4 to the IL-2R promoter followed by recruitment of CREB-binding protein, associated with increased histone acetylation and decreased methylation of the CD25 promoter. PMID: 15546391 STAT4 also enhances the binding of cJun to the locus.

Go back
1041.0, 1841.0
21.0, 21.0

p71

p71

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e87

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c206 : 1

m91*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-12 has been shown to induce IL-2R expression in a STAT4-dependent manner.

Go back
1029.0, 1369.0
21.0, 21.0

p72

p72

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

MO000090987 e38

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c208 : 1
stoichiometry:c209 : 1

m64461*m39*0.1

nodelay

--

true

0

false

PMID: 15546391, 14607827 Indeed, a T-bet-binding element has been identified recently that is upstream of the IFN-G gene, but the function of element has yet to be determined. PMID: 15546391, 10761931, 11397944 T-bet is another transcription factor that has been implicated as a critical regulator of Th1 differentiation and IFN-g expression. PMID: 15546391, 14607827 A distal, upstream T-bet-binding site has been defined near the same region.

Go back
975.0, 1423.0
17.0, 17.0

p73

p73

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e90

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c211 : 1

m95*0.1

nodelay

--

true

0

false

PMID: 15546391, 14607827 Indeed, a T-bet-binding element has been identified recently that is upstream of the IFN-G gene, but the function of element has yet to be determined. PMID: 15546391, 10761931, 11397944 T-bet is another transcription factor that has been implicated as a critical regulator of Th1 differentiation and IFN-g expression

Go back
1271.0, 1329.5
22.5, 22.5

p8

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000090987 MO000017053

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c33 : 1

m64461*0.1

nodelay

--

true

0

false

PMID: 15546391, 11752460, 12006974 In Th1 cells, IFN-g stimulation upregulates the transcription factor T-bet, which in turn promotes IL-12Rb2 chain expression PMID: 15546391, 9120387, 9120388, 10566142 In contrast, IL-4 inhibits IL-12Rb2 expression

Go back
1803.0, 883.0
17.0, 17.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e27 e29 e31

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m28*m30*m32*0.1

nodelay

--

true

0

false

PMID: 15546391 IL-23 binds a receptor composed of IL-12Rb1 and a second subunit designated IL-23R

Go back
1305.0, 1624.0

c1

c1

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1580.9298357878688, 1635.7232448028267

c10

c10

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1404.5689290811056, 799.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1430.1609717162462, 805.1126402596674

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1376.0, 548.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1376.0, 617.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1386.281356819399, 623.7579570718514

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1265.0, 616.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1268.0, 672.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1280.4639513806405, 677.8433924487405

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1180.0, 834.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1180.0, 924.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1305.0, 1628.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1187.0, 834.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1191.099660075834, 922.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1239.3914313453247, 705.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1187.3854596355657, 740.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1182.0, 1008.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1159.0955145420758, 1505.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1161.0, 1507.4413666296703

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
349.9012112064329, 1309.253340125959

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1189.0, 1008.0

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1576.0, 1424.0

c119

c119

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1574.0, 1627.2489339272965

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1257.8805700005814, 1418.0

c120

c120

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1424.8237034496276, 1075.670228826325

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1391.2950039375453, 1046.7492919018569

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1195.0, 1001.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
998.0, 748.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1080.0, 757.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1080.272568930266, 650.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
981.0, 828.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1095.0, 644.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1180.498323742099, 725.7883939927266

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1578.40419736283, 1695.8986990823046

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1173.0, 501.0481080503993

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1140.4618485406781, 834.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1138.0, 930.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1087.0, 841.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1100.0, 352.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1174.0, 376.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1124.0, 444.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1210.0, 464.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1208.5347985803924, 388.0

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1170.477422065255, 147.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1581.5751605461203, 1630.793941768694

c14

c14

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1304.0, 464.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1058.9543209514236, 1051.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
989.0, 1084.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1059.9688191088742, 1085.7056358905568

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1555.0, 1227.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1564.0, 1272.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1578.2921637076142, 1152.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1420.0, 952.0

c147

c147

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1356.4394090302176, 975.7470002466348

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1333.0, 882.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1086.0, 1696.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1313.1877316447983, 932.0899458438937

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1505.1804964634343, 647.8208100192876

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1496.0, 528.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1503.1567962775466, 648.3508256177158

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
807.0, 552.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
958.0, 552.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
964.3375302972698, 564.8821828858808

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
888.0, 945.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
888.0, 1010.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
905.882835533192, 1003.3641495360283

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1202.0, 1696.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.0, 724.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
721.8529642184483, 782.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
749.4852004279334, 778.8234331147852

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
807.0, 475.27194393110386

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
942.0, 470.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
949.6998012557914, 469.1709584568371

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
678.2235169765557, 724.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
671.0, 774.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.9770261172122, 685.0

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1037.9508659648134, 1098.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1204.6920784972147, 1656.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
737.869601848333, 1154.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1036.625862917202, 691.0

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1153.68, 1100.0

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.0, 1208.0

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1137.796029752168, 147.0

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
830.9978057816382, 1096.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
735.765261990441, 1119.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
324.0, 1112.0

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
737.9725349859352, 1180.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
342.0, 1184.5234327944352

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1158.0, 1649.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.8727028887965, 1099.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
737.4530574940025, 1147.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.9779301868102, 1097.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
318.0, 1145.9338963582722

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
866.0, 1508.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
438.0, 1508.078620281758

c185

c185

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1436.0, 1717.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1444.5618108243373, 1157.0

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
330.0, 1642.0

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
770.0, 1654.7339445046937

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1141.0, 1674.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
631.97685483905, 1625.6081010415419

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
317.77201272554436, 1551.8962642732429

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
330.0, 1625.412733746053

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
992.7333177430612, 1100.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
737.9402762089536, 1210.9757119070325

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
310.0, 1248.3179463371293

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
729.3502914649621, 1407.1580398002727

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
349.7699701092493, 1310.904616628451

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
712.1915618245595, 1222.0

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1057.375210522901, 1239.0

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1578.0, 1624.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1209.7766576685863, 1687.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1026.1554175279994, 1440.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
950.0, 1800.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1022.0, 1800.0909032218306

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1027.2781897671837, 1413.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.0, 1753.0

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1068.925878648913, 1809.0

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1052.0, 1862.0

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1029.0703033307766, 1751.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1057.836468262882, 1383.609274732556

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
970.0, 1380.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1192.0, 1650.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 1389.0

c210

c210

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
992.0, 1440.0

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
722.0, 856.0

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1001.9684350024883, 1587.0

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1720.0, 980.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1852.0, 1016.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1728.0, 1016.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1734.0, 1234.6168845110653

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1865.0, 1228.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1742.0, 1228.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1204.0, 1246.6568542494924

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1309.0, 1232.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1581.138000478385, 1450.0

c3

c3

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1129.0, 1305.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
342.0, 1300.0729136380564

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
342.0, 1233.6142154057034

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1294.0, 1345.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1299.6568542494924, 1248.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1297.999992219405, 1340.0

c35

c35

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1828.0, 892.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1720.0, 904.0249509284532

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1731.0, 843.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1736.1770689798384, 803.0990127707684

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1581.4273506299885, 1479.0

c4

c4

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1716.0, 921.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1665.0, 940.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1727.8081724776093, 942.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1657.0, 1300.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1733.0, 1302.0143041918768

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1741.8709592807993, 1275.4310835055999

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1731.0, 841.2131489800478

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1650.0, 852.1747905414899

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1739.0, 836.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1734.0, 1187.3361829423372

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1581.734902230893, 1523.0

c5

c5

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1733.0, 1180.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1725.0, 1149.2987830845307

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1734.0, 1144.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1627.3618856000535, 1106.1309168643907

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1534.0, 1097.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1620.0, 1100.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1728.0, 1100.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1730.604843651928, 1066.4832142536907

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1589.7572902970137, 1028.9556194026084

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1400.0, 1024.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1581.9370848279755, 1594.0

c6

c6

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1582.0, 1032.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1365.6379617782632, 1040.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1374.0, 1178.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1500.0, 1213.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1381.440446698827, 1308.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1375.0, 1408.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1317.0, 1434.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1436.0, 1456.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1436.0, 1513.0

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1168.9971892689439, 1576.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1581.9563607115272, 1626.589245212355

c7

c7

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1731.0, 761.0730285286988

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1729.7561004513302, 731.9603330811054

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1722.0, 690.7045782844609

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1731.0, 684.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1645.0, 684.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1540.0, 684.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1637.0, 637.5066945971321

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1730.0, 624.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1733.8599434057003, 567.1159660434203

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1619.0, 556.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1581.776980405366, 1628.3169734308185

c8

c8

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1600.0, 567.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1610.0, 567.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1600.0, 762.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1600.0, 815.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1516.2625860380488, 874.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1181.283631002235, 954.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1179.0, 1469.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1307.0, 1440.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1376.0, 1498.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1373.4132406834244, 1540.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1581.3053547202355, 1633.252693981307

c9

c9

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1168.9566919427953, 1586.8312961731278

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
942.7471339191503, 1455.995473888266

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1179.0, 1397.1744587445608

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1253.0, 1321.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1178.9952479948288, 1381.2756982067183

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1144.0, 1388.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1475.819255247295, 806.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1422.0, 868.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1477.3985110936076, 882.9039036215198

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1435.0, 788.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back