1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15618008.csml convertedTime:2009.07.01.10:49

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title TICAM-1 and TICAM-2: toll-like receptor adapters that participate in inductionof type 1 interferons.
Authors Seya T, Oshiumi H, Sasai M, Akazawa T, Matsumoto M.
Affiliation Department of Immunology, Osaka Medical Center for Cancer and CardiovascularDiseases, Higashinari-ku, Osaka 537-8511, Japan. seya-tu@med.hokudai.ac.jp
Abstract Toll-like receptor (TLR) 3 and 4 mediate the expression of many genes, includingNF-kappaB- and interferon-regulatory factor (IRF)-3/interferon (IFN)-induciblegenes, in macrophages and dendritic cells (DCs) in response to their ligandstimuli, polyI:C and lipopolysaccharide (LPS). Toll-IL-1 receptor homologydomain (TIR)-containing adapter molecule 1 (TICAM-1) facilitates expression ofIFN-inducible genes via TLR3. Although MyD88 and Mal/TIRAP adapters functiondownstream of TLR4, they barely induce IFN-beta. In addition, DC maturation aswell as IFN-beta induction are largely independent of MyD88 and Mal/TIRAP.TICAM-1 is the functional adapter for both TLR3 and TLR4 that induces type 1 IFNand MyD88-independent DC maturation. In LPS-mediated TLR4 activation, a complexof TICAM-1 and an additional TLR4-binding adapter serves as the adapter. Wenamed this TLR4-TICAM-1-bridging adapter TICAM-2. Our results reveal the detailsof MyD88-independent pathways which separately recruit the distinct adaptersdownstream of TLR3 and TLR4 and variations of the TLR output are in partregulated by the two additional adapters in DCs.
PMID 15618008
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010657:IL-12 p40 G010859:CD86 G012224:CD80 G027461:CD83 MO000000058:NF-kappaB MO000000212:TRAF6 MO000007694:IRF-3 MO000016573:MyD88 MO000016882:LPS MO000019394:TLR4 MO000019398:TLR3 MO000022224:dsRNA MO000022528:TIRAP MO000041125:TRIF MO000041132:TRAM MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 e1: e10:TRIF:TRAM e11:TRAM:TRAM e12:TLR4:LPS:TRIF:TRAM e13:IRF-3:IRF-3{active} e14:LPS:TLR4:MyD88 e15:NF-kappaB{active} e16:RIP1 e17:dsRNA:TLR3:TRIF:RIP1 e18:TLR4:LPS:TRIF:TRAM:RIP1 e19:NAP1:IKK-i:TBK1 e2: e20:dsRNA:TLR3:TRIF:Kinase complex e21:IRF-3 e22:LPS:TLR4:MyD88:TIRAP e23:TLR4:LPS:TRIF:TRAM:Kinase complex e24:dsRNA:TLR3:TRIF:TRAF6 e25:TLR4:LPS:TRIF:TRAM:TRAF6 e3: e4: e5:TLR4:LPS e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR4:LPS:TRAM e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p4 p5 p6 p7 p8 p9
Model Detail
456.0, 940.0
32.0, 32.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p13

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
719.0, 879.0
25.5, 25.5

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p23

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
550.0, 858.0
28.0, 28.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p21

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
642.0, 942.0
28.0, 28.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p22

--

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
512.0, 1124.0
32.0, 32.0

CD86

--

G010859

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p29 p32 p35

--

true true true true

csml-variable:Double

m93745

10

false

infinite

0

unit false false false
TRANSFACG010859

--

Go back
639.0, 1135.0
26.0, 26.0

CD80

--

G012224

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p30 p33 p36

--

true true true true

csml-variable:Double

m95018

10

false

infinite

0

unit false false false
TRANSFACG012224

--

Go back
364.0, 1080.0
32.0, 32.0

CD83

--

G027461

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p26 p31 p34

--

true true true true

csml-variable:Double

m106162

10

false

infinite

0

unit false false false
TRANSFACG027461

--

Go back
616.0, 360.0
31.0, 31.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p11 p12 p16

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
691.0, 227.0
26.0, 26.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p28

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
406.0, 454.0
27.0, 27.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8 p19 p25

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
969.0, 749.0
30.5, 30.5

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1162.0, 234.0
28.0, 28.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1062.0, 234.0
28.0, 28.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
332.0, 116.0
24.0, 24.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
462.0, 46.0
28.0, 28.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
837.0, 849.0
30.0, 30.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
526.0, 226.0
28.0, 28.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p14

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
887.0, 275.0
25.0, 25.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p5 p14

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
248.0, 108.0
32.0, 32.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p15 p18 p27 p34 p35 p36

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
463.0, 115.0
26.0, 26.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p2

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
149.1205119100087, 92.94884051436408
973.4851556526595, 1413.5004460076607

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
821.5, 375.0
28.023329445092482, 34.314280953174475

TRIF:TRAM

--

e10

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p14

p6

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
698.5, 290.0
30.61173137810364, 37.48375270788202

TRAM:TRAM

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1073.5, 544.0
29.079647641769128, 40.57625252339879

TLR4:LPS:TRIF:TRAM

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p6

p17 p19 p24 p28 p31 p32 p33

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
245.5, 518.0
29.80336610564905, 36.4939176803866

IRF-3:IRF-3{active}

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7 p8 p25

p13

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1068.5, 706.0
31.739034685263356, 44.28702514222793

LPS:TLR4:MyD88

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p11 p20

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
560.0, 600.0
31.0, 31.0

NF-kappaB{active}

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10 p11 p12 p16

p21 p22 p23

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
468.0, 342.0
15.626753975678206, 36.06173994387278

RIP1

--

e16

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p15 p17

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
162.0, 261.0
27.08823529411764, 45.14705882352941

dsRNA:TLR3:TRIF:RIP1

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

p16

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1073.0, 620.0
29.29411764705882, 48.82352941176471

TLR4:LPS:TRIF:TRAM:RIP1

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p17

p12

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
518.5, 284.0
27.98274912828042, 39.045696458065706

NAP1:IKK-i:TBK1

--

e19

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

--

p18 p24

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
149.1205119100087, 92.94884051436408
973.4851556526595, 1413.5004460076607

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
190.0, 137.0
27.17647058823529, 45.294117647058826

dsRNA:TLR3:TRIF:Kinase complex

--

e20

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p18

p7

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
394.0, 574.0
27.0, 27.0

IRF-3

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19

--

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1068.0, 853.0
30.79411764705882, 51.3235294117647

LPS:TLR4:MyD88:TIRAP

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p10 p26 p29 p30

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
177.0, 652.0
29.29411764705882, 48.82352941176471

TLR4:LPS:TRIF:TRAM:Kinase complex

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

p25

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
680.0, 108.0
23.91176470588236, 39.852941176470594

dsRNA:TLR3:TRIF:TRAF6

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p27

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
884.0, 108.0
23.91176470588236, 39.852941176470594

TLR4:LPS:TRIF:TRAM:TRAF6

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p28

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
168.59021502306183, 112.41854362741731
934.5457494265531, 1374.5610397815553

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
204.60916578221043, 146.49052407526023
862.5078479082562, 1306.417078885868

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1067.5, 304.0
24.699408024556018, 47.80530585397939

TLR4:LPS

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p4 p6 p9

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
263.1844430478182, 732.1128447825334
559.5941231551095, 507.49038729336803

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
323.62477664743886, 744.1396291864097
327.2114612117406, 491.85926653484506

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
270.4789660684621, 738.8863304445598
545.0050771138223, 493.9434159693152

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
271.5210407856969, 739.9284051617948
542.9209276793531, 491.85926653484506

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
263.1844430478182, 732.1128447825334
559.5941231551095, 507.49038729336803

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
263.1844430478182, 732.1128447825334
559.5941231551095, 507.49038729336803

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
271.5210407856969, 739.9284051617948
542.9209276793531, 491.85926653484506

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
671.6777322038764, 940.5277882295027
34.96036612254187, 31.648331437248434

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
579.9751570872099, 1086.4182486423795
98.99709813730996, 89.61842568219643

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
263.1844430478182, 732.1128447825334
559.5941231551095, 507.49038729336803

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1070.5, 417.0
27.130482657368322, 37.856487428886034

TLR4:LPS:TRAM

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
395.077629256071, 957.6373794681139
17.721523643129323, 8.532585457803016

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
394.4858574194085, 932.1911904916234
60.65661325791483, 109.1819038642467

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
419.9320463959, 1003.2038108911343
9.468349386601325, 9.468349386601327

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
174.85950019395185, 152.24331453480698
914.7368364413699, 1296.1584693486566

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
144.6300033086437, 181.9439630359788
873.5327165422767, 1268.3695044193862

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
150.916895374207, 146.98606248141274
909.1597420637062, 1308.7623836612863

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
383.0, 47.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 15618008 We also showed that polyI:C was a ligand of TLR3 and stimulation of TLR3 with polyI:C induced a high level of IFN-beta

Go back
738.0, 746.0
27.0, 27.0

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e22

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c57 : 1
stoichiometry:c28 : 1

m15*m23*0.1

nodelay

--

true

0

false

PMID: 15618008 Moderate activation of NF-KappaB was induced by MyD88 or Mal/TIRAP and TICAM-1

Go back
758.0, 674.0
27.0, 27.0

p10

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e14 MO000000058

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m14*m15*0.1

nodelay

--

true

0

false

PMID: 15618008 Moderate activation of NF-KappaB was induced by MyD88 or Mal/TIRAP and TICAM-1

Go back
766.0, 602.0
27.0, 27.0

p10

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e18

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c47 : 1
stoichiometry:c34 : 1

m15*m19*0.1

nodelay

--

true

0

false

PMID: 15618008 Moderate activation of NF-KappaB was induced by MyD88 or Mal/TIRAP and TICAM-1 PMID: 15618008,15064760 TICAM-1 recruits RIP1 in its C-terminal domain and induces NF-kappaB activation

Go back
474.0, 806.0
27.0, 27.0

p13

p13

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 15618008 Robust activation of the IFN-beta promoter was observed when cells were transfected with TICAM-1 PMID: 15618008 Interferon-regulatory factor (IRF)-3 dimerizes as a result of TICAM-1 transfection suggesting TICAM-1 is the molecule that activates IRF-3, which in turn enhances activation of the IFN promoter

Go back
703.0, 363.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000041125 MO000041132

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m18998*m19005*0.1

nodelay

--

true

0

false

PMID: 15618008 TICAM-2 appears to bridge TLR4 and TICAM-1 by forming heterodimers with TICAM-1. PMID: 15618008 TLR4 recruited TICAM-2 in the absence of TICAM-1, but TLR4 recruited TICAM-1 only in the presence of TICAM-2.

Go back
379.0, 271.0
25.0, 25.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000041437 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m19305*m17*0.1

nodelay

--

true

0

false

PMID: 15618008,15064760 TICAM-1 recruits RIP1 in its C-terminal domain and induces NF-kappaB activation

Go back
487.0, 423.0
25.0, 25.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e17 MO000000058

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m18*m15*0.1

nodelay

--

true

0

false

PMID: 15618008,15064760 TICAM-1 recruits RIP1 in its C-terminal domain and induces NF-KappaB activation

Go back
719.0, 443.0
25.0, 25.0

p15

p17

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e16 e12

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m17*m12*0.1

nodelay

--

true

0

false

PMID: 15618008,15064760 TICAM-1 recruits RIP1 in its C-terminal domain and induces NF-kappaB activation

Go back
377.0, 213.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000041437 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m19305*m20*0.1

nodelay

--

true

0

false

PMID: 15618008,15611223 TICAM-1 recruits a kinase complex consisting of NAP1, IKKepsilon, and TBK1 to induce IRF-3 activation

Go back
451.0, 519.0
25.0, 25.0

p19

p19

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e12 MO000007694

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m12*m977*0.1

nodelay

--

true

0

false

PMID: 15618008 IRF-3 phosphorylation induced by TICAM-1 transfection was also promoted in the presence of TICAM- 2.

Go back
427.0, 195.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 15618008 No direct association was observed between TICAM-1 and the TLR4 TIR while TICAM-1 strongly bound TLR3

Go back
929.0, 881.0
22.0, 22.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000022528 e14

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m6810*m14*0.1

nodelay

--

true

0

false

PMID: 15618008 Moderate activation of NF-KappaB was induced by MyD88 or Mal/TIRAP and TICAM-1

Go back
543.0, 779.0
25.0, 25.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e15

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 15618008 These two adapters mediate the NF-KappaB activation and IRF-3 activation respectively resulting in the reported cytokine induction (TNF-alpha, IL-6 and IL-12p40).

Go back
623.0, 871.0
25.0, 25.0

p21

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e15

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c62 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 15618008 These two adapters mediate the NF-KappaB activation and IRF-3 activation respectively resulting in the reported cytokine induction (TNF-alpha, IL-6 and IL-12p40).

Go back
671.0, 819.0
25.0, 25.0

p21

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e15

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c63 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 15618008 These two adapters mediate the NF-KappaB activation and IRF-3 activation respectively resulting in the reported cytokine induction (TNF-alpha, IL-6 and IL-12p40).

Go back
599.0, 563.0
25.0, 25.0

p18

p24

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e19 e12

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m20*m12*0.1

nodelay

--

true

0

false

PMID: 15618008,15611223 TICAM-1 recruits a kinase complex consisting of NAP1, IKKepsilon, and TBK1 to induce IRF-3 activation

Go back
332.0, 696.0
23.0, 23.0

p7

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e23 MO000007694

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m24*m977*0.1

nodelay

--

true

0

false

PMID: 15618008,12539043,12471095 Interferon-regulatory factor (IRF)-3 dimerizes as a result of TICAM-1 transfection suggesting TICAM-1 is the molecule that activates IRF-3, which in turn enhances activation of the IFN promoter PMID: 15618008,15611223 TICAM-1 recruits a kinase complex consisting of NAP1, IKKepsilon, and TBK1 to induce IRF-3 activation

Go back
365.0, 1021.0
21.0, 21.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e22

G027461

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 15618008 The maturation markers of DCs, CD80, CD83 and CD86, are upregulated by TLR signaling.

Go back
586.0, 206.0
27.0, 27.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000041437 MO000000212

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m19305*m183*0.1

nodelay

--

true

0

false

PMID: 15618008,14530355 TRAF6 was reported to bind the N-terminus of TICAM-1, but the macrophages from TRAF6 gene-disrupted mice expressed no phenotype related to TICAM-1 activation

Go back
754.0, 198.0
27.0, 27.0

p27

p28

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000000212 e12

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m183*m12*0.1

nodelay

--

true

0

false

PMID: 15618008,14530355 TRAF6 was reported to bind the N-terminus of TICAM-1, but the macrophages from TRAF6 gene-disrupted mice expressed no phenotype related to TICAM-1 activation

Go back
493.0, 1065.0
21.0, 21.0

p26

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e22

G010859

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c80 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 15618008 The maturation markers of DCs, CD80, CD83 and CD86, are upregulated by TLR signaling.

Go back
1140.0, 316.0
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019394 MO000016882

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m3961*m155666*0.1

nodelay

--

true

0

false

PMID: 15618008,12893815 TLR4 also induces activation of the IFN-beta promoter in response to lipopolysaccharide (LPS)

Go back
637.0, 1053.0
21.0, 21.0

p26

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e22

G012224

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c81 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 15618008 The maturation markers of DCs, CD80, CD83 and CD86, are upregulated by TLR signaling.

Go back
449.0, 1045.0
21.0, 21.0

p26

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e12

G027461

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c85 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 15618008 The maturation markers of DCs, CD80, CD83 and CD86, are upregulated by TLR signaling.

Go back
585.0, 1073.0
21.0, 21.0

p26

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e12

G010859

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c86 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 15618008 The maturation markers of DCs, CD80, CD83 and CD86, are upregulated by TLR signaling.

Go back
717.0, 1073.0
21.0, 21.0

p26

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e12

G012224

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c87 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 15618008 The maturation markers of DCs, CD80, CD83 and CD86, are upregulated by TLR signaling.

Go back
309.0, 973.0
21.0, 21.0

p26

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041437

G027461

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m19305*0.1

nodelay

--

true

0

false

PMID: 15618008 The maturation markers of DCs, CD80, CD83 and CD86, are upregulated by TLR signaling.

Go back
541.0, 945.0
21.0, 21.0

p26

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041437

G010859

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m19305*0.1

nodelay

--

true

0

false

PMID: 15618008 The maturation markers of DCs, CD80, CD83 and CD86, are upregulated by TLR signaling.

Go back
717.0, 973.0
21.0, 21.0

p26

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041437

G012224

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m19305*0.1

nodelay

--

true

0

false

PMID: 15618008 The maturation markers of DCs, CD80, CD83 and CD86, are upregulated by TLR signaling.

Go back
932.0, 336.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041132 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m19005*m5*0.1

nodelay

--

true

0

false

PMID: 15618008,14519765 TICAM-2 (or TRAM) was cloned as a TLR4- binding protein in yeast PMID: 15618008 TLR4 directly recruits TICAM-2, but not TICAM-1 PMID: 15618008,14519765 Physical association of HA-tagged TICAM-2 with Flag-Tagged TLR4 tested by immunoprecipitation and Western blotting confirmed direct binding of TICAM-2 to TLR4 in HEK293 cells

Go back
795.0, 275.0
25.0, 25.0

p5

p5

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041132

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m19005*0.1

nodelay

--

true

0

false

PMID: 15618008 When over-expressed in HEK cells, TICAM-2 formed dimers

Go back
848.0, 464.0
23.0, 23.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e10 e5

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1

m10*m5*0.1

nodelay

--

true

0

false

PMID: 15618008 TLR4 recruited TICAM-2 in the absence of TICAM-1, but TLR4 recruited TICAM-1 only in the presence of TICAM-2 PMID: 15618008 TICAM-2 appears to bridge TLR4 and TICAM-1 by forming heterodimers with TICAM-1.

Go back
308.0, 312.0
23.0, 23.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e20

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c50 : 1
stoichiometry:c21 : 1

m977*m21*0.1

nodelay

--

true

0

false

PMID: 15618008,12539043,12471095 Interferon-regulatory factor (IRF)-3 dimerizes as a result of TICAM-1 transfection suggesting TICAM-1 is the molecule that activates IRF-3, which in turn enhances activation of the IFN promoter PMID: 15618008,15611223 TICAM-1 recruits a kinase complex consisting of NAP1, IKKepsilon, and TBK1 to induce IRF-3 activation

Go back
319.0, 431.0
25.0, 25.0

p8

p8

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000007694

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m977*0.1

nodelay

--

true

0

false

PMID: 15618008,12539043,12471095 Interferon-regulatory factor (IRF)-3 dimerizes as a result of TICAM-1 transfection suggesting TICAM-1 is the molecule that activates IRF-3, which in turn enhances activation of the IFN promoter

Go back
827.0, 643.0
25.0, 25.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000016573

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m5*m1572*0.1

nodelay

--

true

0

false

PMID: 15618008 Moderate activation of NF-KappaB was induced by MyD88 or Mal/TIRAP and TICAM-1

Go back
353.0, 78.33028001113733

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
909.0, 300.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
962.9209918144369, 330.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
955.0, 355.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.0, 288.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.8010628463317, 291.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.0, 409.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.6303991849644, 336.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
871.0, 480.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
792.9364913754995, 691.006034118021

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
280.0, 137.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
416.0, 60.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
332.53927610216886, 341.5874860507085

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.186658885424, 335.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.7152317131197, 449.11546676004895

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
278.9604359425147, 456.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
854.7233915560533, 345.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
858.3934366569679, 669.8087386821638

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
852.0, 660.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.0, 391.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
597.1766546017213, 633.0841850803284

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
277.0, 140.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
408.0, 70.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
639.0, 391.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
598.514398285166, 624.7447802119468

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.0, 363.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
641.0, 391.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.0, 616.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
275.0, 554.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
474.8916066831047, 833.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.0, 251.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
735.2178418213261, 294.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.0, 378.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
449.2491077284276, 141.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
409.9278956114879, 300.3721553979109

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
197.0, 284.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
189.0, 290.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
519.2636750760037, 383.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.0, 448.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
751.6561952354677, 462.32005916226296

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
744.0, 462.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
800.965731653334, 617.7396750820953

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
409.0185744968183, 236.83922023757583

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.55086685092814, 167.64280339782485

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
459.6097825515901, 214.46803758429948

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
217.0, 179.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
483.9899519608442, 533.4008337104102

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
429.0, 481.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.65685424949237, 544.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
867.0, 869.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
955.2900319205088, 746.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
951.0, 880.7488344793611

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
772.527732505779, 767.7079961819469

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
557.9129161746642, 631.0

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
557.0, 804.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
287.2228841505914, 135.43946864313878

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
579.0, 631.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
583.0, 631.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
639.0, 896.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
693.0, 844.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
538.0, 323.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
631.9971570716941, 564.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
213.7805337708841, 579.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
206.0, 679.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
350.41244650298336, 481.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.49640308081183, 561.1954961952939

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1089.0, 262.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.0, 129.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
620.8560515758452, 223.510779149201

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
613.0, 145.65685424949237

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.0, 221.17528920548375

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
785.3850280392456, 230.9162042744093

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
781.0, 140.3621950356683

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
665.3577934305443, 885.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.5715121269759, 884.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
393.81803115098694, 882.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
377.0, 1042.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1158.272706637531, 262.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.0, 1086.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
648.0, 1074.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
476.29849934262324, 575.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
611.5019571832863, 579.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
740.5550812907378, 585.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
403.12831597487434, 1061.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
550.1580636831471, 1093.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
671.1070902829529, 1093.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
265.0, 140.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
325.0, 994.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1100.0, 328.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
270.0, 140.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
531.0540220154127, 966.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
273.0, 140.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
661.3491975706694, 994.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back