1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15662540.csml convertedTime:2009.07.01.10:49

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Modulation of Toll-interleukin 1 receptor mediated signaling.
Authors Li X, Qin J.
Affiliation Department of Immunology, Lerner Research Institute, Cleveland ClinicFoundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. lix@ccf.org
Abstract Toll-like receptors (TLRs) belong to the Toll-interleukin 1 receptorsuperfamily, which is defined by a common intracellular Toll-IL-1 receptor (TIR)domain. A group of TIR domain containing adaptors (MyD88, TIRAP, TRIF and TRAM),are differentially recruited to the Toll-IL-1 receptors, contributing to thespecificity of signaling. The IL-1 mediated signaling pathway serves as a"prototype" for other family members. Genetic and biochemical studies revealthat IL-1R uses adaptor molecule MyD88 to mediate a very complex pathway,involving a cascade of kinases organized by multiple adapter molecules intosignaling complexes, leading to activation of the transcription factor NFkappaB.Several Toll-like receptors utilize variations of the "prototype" pathway byemploying different adaptor molecules. Double-stranded RNA triggered,TLR3-mediated signaling is independent of MyD88, IRAK4, and IRAK. The adaptermolecule TRIF is utilized by TLR3 to mediate the activation of NFkappaB andIRF3. LPS-induced, TLR4-mediated signaling employs multiple TIR-domaincontaining adaptors, MyD88/TIRAP to mediate NFkappaB activation, TRIF/TRAM forIRF3 activation. Recent studies have also begun to unravel how these pathwaysare negatively regulated. SIGIRR (also known as TIR8), a member of TIRsuperfamily that does not activate the transcription factors NFkappaB and IRF3,instead negatively modulates responses. Cells from SIGIRR-null mice showenhanced activation in response to either IL-1 or certain Toll ligands. Inaddition to SIGIRR, several other negative regulators have been shown to inhibitthe TIR signaling, including ST2, IRAKM, MyD88s, SOCS1, and Triad3A. Thecoordinated positive and negative regulation of the TIR signaling ensures theappropriate modulation of the innate and inflammatory responses.
PMID 15662540
Model Abstract

Entity

G010228:IFN-beta G010329:TNF-alpha G010539:SOCS1 MO000000022:p38 MO000000023:JNK MO000000065:RIP1 MO000000212:TRAF6 MO000000213:IRAK MO000000214:IL-1 MO000000220:IkappaB-alpha{p}: NFkappaB MO000000233:IkappaB-alpha: NFkappaB MO000000276:AP-1 MO000000289:TNF-alpha MO000009093:MEKK3 MO000016569:IRAK-M MO000016573:MyD88 MO000016574:TAK1 MO000016588:TAB1 MO000016595:IL-1RI MO000016882:LPS MO000017462:CBP MO000018944:Uba MO000019394:TLR4 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019422:TLR6 MO000019984:p300 MO000022125:TAB2 MO000022136:Ubc13 MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041419:Pellino1 MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000044786:ST2 MO000050640:MyD88:MyD88 MO000066718:SIGIRR e1: e10: e100:e100 e101:IKKe e102:TLR4:MyD88 e103:TLR4:MyD88: TIRAP e104:LPS:TLR4: TIRF e105:LPS:TLR4: TIRF: TRAM e106:IRF-3 {p}: IRF-3: p300 {nucleus} e11:NF-kappaB [activated} e12:IkappaB-alpha{ub}: NFkappaB e13:IkappaB-alpha {degraded} e14:NF-kappaB [nucleus} e15:IL-1: IL-1RI e16:IL-1: IL-1RI: MyD88 e17:IL-1: IL-1RI: MyD88: IRAK: IRAK-4 e18:IL-1: IL-1RI: MyD88: IRAK {p}: IRAK-4: TRAF6 e19:IL-1: IL-1RI: MyD88: IRAK {p}: IRAK-4 e2: e20:IL-1: IL-1RI: MyD88: IRAK [p}: IRAK-4: TRAF6: Pellino1 e21:IRAK {p}: IRAK-4: TRAF6: Pellino1 e22:IRAK {p}: TRAF6: TAK1: TAB1: TAB2 e23:IRAK {p}: TRAF6: TAK1 {p}: TAB1: TAB2 {p} e24:IRAK-4: Pellino1 e25:IRAK {p}: TRAF6: TAK1 {p}: TAB1: TAB2 {p} e26:IRAK {p}: TRAF6: TAK1 {p}{activated}: TAB1: TAB2 {p} e27:MAPK6 e28:MAPK {activated} e29:JNK {activated} e3: e30:ATF e31:ATF {activated} e32:AP-1 {activated} e33:IRAK {p}: TRAF6: TAK1 {p}: TAB1: TAB2 {p} : Ubc13: Uev1A e34:Uev1A e35:IRAK {p}: TRAF6 {ub}: TAK1 {p}: TAB1: TAB2 {p} : Ubc13: Uev1A e36:MEKK3: TRAF6 e37:dsRNA:TLR3:TRIF:TRAF6:TAK1:TAB2 e38:dsRNA:TLR3:TRIF:TRAF6:TAK1:TAB2: RIP1 e39:NF-kappaB e4: e40:IRF-3 {p} e41:TBK1: IKK-i e42:TBK1: IKK-i {activated} e43:IRF-3 e44:MyD88: TIRAP: ST2 e45:IL-1: IL-1RI: MyD88: IRAK {p}: IRAK-4: TRAF6: SIGIRR e46:IRAK-2d e47:IRAK-2c e48:IRAK-2b e49:IRAK-2a e5:IKK-alpha: IKK-beta: IKK-gamma e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IKK-alpha {p}: IKK-beta {p}: IKK-gamma e60: e61: e62: e63:IRAK-2c e64:LPS: TLR4 e66:IL-1: IL-1RI: MyD88s e67:MyD88s e68:SOCS1 e69:NO2- e7: e70:Ubiquitin e71:P38 {p} e72:TLR6: TLR2 e73:Uba: ubiquitin e74:lipoprotein e75:Ubc e76:lipoprotein: TLR6: TLR2 e77:Ubc: ubiquitin e78:fagellin e79:TLR4{ub} e8: e80:UBR e81:IRF-3 {p}: IRF-3: p300 e82:Triad3A e83:TLR9{ub} e84:TLR9 {degraded} e85:TLR4 {degraded} e86:TRAF6: TAK1: TAB2 e87:TRAF6: TAK1 {p}: TAB2 e88:flagellin e89:bacterial DNA e9: e90:bacterial DNA: TLR9 e91:R848 e92:R848: TLR7 e93:R848: TLR8 e94:ssRNA e95:ssRNA: TLR7 e96:ssRNA: TLR8 e97:IRF-3 {p}: IRF-3 e98:IRF-3 {p}: IRF-3: CBP e99:IRF-3 {p}: IRF-3: CBP{nucleus}

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p9
Model Detail
443.0, 1211.0
34.0, 34.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p76

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
580.0, 1360.0
39.0, 39.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p45

p44

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
567.0, 1307.0
34.0, 34.0

SOCS1

--

G010539

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p41

p42

true true true true

csml-variable:Double

m93501

10

false

infinite

0

unit false false false
TRANSFACG010539

--

Go back
636.0, 916.0
31.0, 31.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
820.0, 828.0
40.0, 40.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
283.0, 344.0
37.0, 37.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
875.0, 260.0
37.0, 37.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p17 p27

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
704.0, 257.0
36.0, 36.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
417.0, 96.0
36.0, 36.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
1066.0, 1059.0
40.5, 40.5

IkappaB-alpha{p}: NFkappaB

--

MO000000220

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p3

true true true true

csml-variable:Double

m190

10

false

infinite

0

unit false false false
TRANSPATHMO000000220

--

Go back
1069.0, 994.0
41.5, 41.5

IkappaB-alpha: NFkappaB

--

MO000000233

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m199

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
655.0, 803.0
34.0, 34.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
786.0, 1367.0
40.0, 40.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
874.0, 407.0
31.0, 31.0

MEKK3

--

MO000009093

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m1116

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000009093

--

Go back
988.0, 341.0
36.0, 36.0

IRAK-M

--

MO000016569

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m1571

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016569

--

Go back
473.0, 317.0
37.0, 37.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

p33 p37 p38 p71

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1061.0, 358.0
50.0, 50.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p27

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1069.0, 414.0
34.0, 34.0

TAB1

--

MO000016588

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m1583

10

false

infinite

0

unit false false false
InterProIPR001932
TRANSPATHMO000016588

--

Go back
414.0, 169.0
42.0, 42.0

IL-1RI

--

MO000016595

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m1589

10

false

infinite

0

unit false false false
InterProIPR004076
TRANSPATHMO000016595

--

Go back
61.0, 949.0
38.0, 38.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
435.0, 619.0
41.0, 41.0

CBP

--

MO000017462

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p68

true true true true

csml-variable:Double

m2282

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000017462

--

Go back
296.0, 560.0
32.0, 32.0

Uba

--

MO000018944

cso30:c:Protein

cso30:i:CC_CellComponent

--

p79

p48

true true true true

csml-variable:Double

m3556

10

false

infinite

0

unit false false false
InterProIPR000594
TRANSPATHMO000018944

--

Go back
191.0, 951.0
34.0, 34.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p51 p52

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
256.0, 1530.0
27.0, 27.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
360.0, 175.0
30.0, 30.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
494.5, 1523.0
31.5, 31.5

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
312.0, 1529.0
28.0, 28.0

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
570.0, 614.0
36.0, 36.0

p300

--

MO000019984

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m4512

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000019984

--

Go back
1067.0, 452.0
38.0, 38.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p27

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
889.0, 493.0
38.0, 38.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
360.0, 107.0
37.5, 37.5

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
686.0, 386.0
36.0, 36.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p72

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
759.0, 260.0
37.0, 37.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
369.0, 224.0
36.5, 36.5

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p74

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
252.0, 1088.0
40.0, 40.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p75

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
1010.0, 247.0
40.0, 40.0

Pellino1

--

MO000041419

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m19287

10

false

infinite

0

unit false false false
TRANSPATHMO000041419

--

Go back
233.0, 176.0
44.0, 44.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26 p57

p27

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
301.0, 172.0
36.0, 36.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

p26

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
832.5, 1517.0
35.5, 35.5

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p63 p65

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
187.0, 679.0
34.0, 34.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53 p54 p61

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
659.0, 1520.0
37.5, 37.5

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62 p64

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
594.0, 311.0
39.5, 39.5

ST2

--

MO000044786

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m22456

10

false

infinite

0

unit false false false
TRANSPATHMO000044786

--

Go back
530.0, 257.0
42.0, 42.0

MyD88:MyD88

--

MO000050640

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37

p7

true true true true

csml-variable:Double

m192928

10

false

infinite

0

unit false false false
TRANSPATHMO000050640

--

Go back
839.0, 316.0
38.0, 38.0

SIGIRR

--

MO000066718

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m41575

10

false

infinite

0

unit false false false
TRANSPATHMO000066718

--

Go back
152.27808714627028, 175.1858738654615
1036.596111830577, 1416.3936320849862

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
167.10805795602573, 194.55633169761464
1004.7790655432466, 1330.104148691885

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
552.0, 1179.0
48.78892733564014, 26.020761245674738

e100

--

e100

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p70 p80

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
572.0, 473.5
39.68, 29.759999999999998

IKKe

--

e101

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p77

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
183.0, 1323.0
42.0, 42.0

TLR4:MyD88

--

e102

cso30:c:Protein

cso30:i:CC_CellComponent

--

p71

p72

true true true true

csml-variable:Double

m105

10

false

infinite

0

unit false false false
TRANSPATHMO000022180

--

Go back
196.5, 1390.0
31.0, 60.0

TLR4:MyD88: TIRAP

--

e103

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p72

p73

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
192.5, 1014.0
26.289848717386537, 50.88357816268362

LPS:TLR4: TIRF

--

e104

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p74

p75

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
192.5, 1118.0
31.0, 60.0

LPS:TLR4: TIRF: TRAM

--

e105

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p75

p30 p76 p78

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
478.5, 1102.0
43.0, 60.0

IRF-3 {p}: IRF-3: p300 {nucleus}

--

e106

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p81

p80

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
748.0, 1068.0
48.0, 48.0

NF-kappaB [activated}

--

e11

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4 p29 p24 p34 p66 p73

p6

true true true true

csml-variable:Double

m11

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000100032

--

Go back
1063.5, 1115.0
45.48075320779871, 55.690718213631065

IkappaB-alpha{ub}: NFkappaB

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1062.0, 1280.0
48.50660539919586, 46.889718552556

IkappaB-alpha {degraded}

--

e13

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
682.0, 1231.0
48.0, 48.0

NF-kappaB [nucleus}

--

e14

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

--

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000100032

--

Go back
480.5, 150.0
36.926770445077835, 71.47116860337647

IL-1: IL-1RI

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p7 p38

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
593.5, 141.0
50.76496382372288, 98.2547686910765

IL-1: IL-1RI: MyD88

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7 p12

p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
779.5, 135.0
53.23218592413946, 103.03003727252793

IL-1: IL-1RI: MyD88: IRAK: IRAK-4

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p8

p10

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
962.5, 117.0
55.31199298399475, 107.0554702916027

IL-1: IL-1RI: MyD88: IRAK {p}: IRAK-4: TRAF6

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p11 p32

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
847.5, 131.0
45.72856829642622, 88.50690638017979

IL-1: IL-1RI: MyD88: IRAK {p}: IRAK-4

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p9

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
152.27808714627028, 175.1858738654615
1036.596111830577, 1416.3936320849862

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1121.5, 100.0
56.481034860776155, 109.31813198859899

IL-1: IL-1RI: MyD88: IRAK [p}: IRAK-4: TRAF6: Pellino1

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p11

p12

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1140.5, 317.0
42.66856303908974, 59.537529821985686

IRAK {p}: IRAK-4: TRAF6: Pellino1

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

p13

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1130.5, 515.0
63.48596072673886, 88.58506147917046

IRAK {p}: TRAF6: TAK1: TAB1: TAB2

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

p14

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1128.5, 617.0
66.17691319508168, 92.33987887685812

IRAK {p}: TRAF6: TAK1 {p}: TAB1: TAB2 {p}

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

p15

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1042.0, 503.0
44.254143646408835, 49.171270718232044

IRAK-4: Pellino1

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
939.5, 476.0
57.567443567627095, 80.32666544320058

IRAK {p}: TRAF6: TAK1 {p}: TAB1: TAB2 {p}

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p21

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
880.5, 768.0
63.0913929161314, 88.03450174343914

IRAK {p}: TRAF6: TAK1 {p}{activated}: TAB1: TAB2 {p}

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

p16

p23 p82

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
890.0, 642.5
35.35999999999999, 26.520000000000007

MAPK6

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
822.0, 710.5
35.84, 26.880000000000003

MAPK {activated}

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

p23

p18

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
752.0, 780.0
40.0, 40.0

JNK {activated}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

p19 p20

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
173.01000938288183, 194.6954280264118
995.1322673573538, 1377.3745237630876

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
833.0, 893.0
37.0, 37.0

ATF

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
InterProIPR000010
TRANSPATHMO000001470

--

Go back
773.0, 901.0
37.0, 37.0

ATF {activated}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19

--

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
InterProIPR000010
TRANSPATHMO000001470

--

Go back
703.0, 851.0
34.0, 34.0

AP-1 {activated}

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

--

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
1045.5, 631.0
52.958891539732065, 73.89612772985868

IRAK {p}: TRAF6: TAK1 {p}: TAB1: TAB2 {p} : Ubc13: Uev1A

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p22

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
817.0, 497.5
45.55846246729724, 28.094385188166637

Uev1A

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p21

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
980.5, 702.0
54.458249220040386, 75.98825472563772

IRAK {p}: TRAF6 {ub}: TAK1 {p}: TAB1: TAB2 {p} : Ubc13: Uev1A

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p16

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
923.5, 381.0
36.09881686385602, 44.20263289451758

MEKK3: TRAF6

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p66

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
164.0, 281.0
60.0, 60.0

dsRNA:TLR3:TRIF:TRAF6:TAK1:TAB2

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27

p28 p57

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
TRANSPATHMO000041496

--

Go back
174.5, 369.0
47.18987064240298, 91.33523350142511

dsRNA:TLR3:TRIF:TRAF6:TAK1:TAB2: RIP1

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

p29

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
884.0, 1064.0
48.0, 48.0

NF-kappaB

--

e39

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p24 p34 p66 p73

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000100032

--

Go back
211.3640655206133, 228.8371478080745
918.424155081891, 1309.0910841997604

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
524.0, 528.0
40.0, 40.0

IRF-3 {p}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

p67 p77 p78

p31

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
413.5, 341.0
49.0, 60.0

TBK1: IKK-i

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p30

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
365.5, 397.0
49.0, 60.0

TBK1: IKK-i {activated}

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p67

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
508.0, 448.0
40.0, 40.0

IRF-3

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p67 p77 p78

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
534.5, 362.0
47.14296201137822, 65.78087722517894

MyD88: TIRAP: ST2

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1062.5, 118.0
47.006358254768706, 90.98004823503618

IL-1: IL-1RI: MyD88: IRAK {p}: IRAK-4: TRAF6: SIGIRR

--

e45

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1015.0, 1291.0
33.0, 33.0

IRAK-2d

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p24 p34 p66 p73

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
959.0, 1335.0
33.0, 33.0

IRAK-2c

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p24 p34 p66 p73

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
907.0, 1335.0
33.0, 33.0

IRAK-2b

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
866.0, 1302.0
35.0, 35.0

IRAK-2a

--

e49

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
1058.5, 800.0
51.68049183336393, 72.11231418608918

IKK-alpha: IKK-beta: IKK-gamma

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p1 p82

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
327.96303453288976, 1070.4363979825475
441.5973261826894, 376.86767147880437

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
375.65883512617813, 1079.3676139171776
258.2151963153902, 365.259837655022

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
333.7194242596659, 1075.4664593061866
430.0845467291372, 366.8075488315263

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
334.54176564920544, 1076.2403148944388
428.4398639500582, 365.259837655022

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
327.96303453288976, 1070.4363979825475
441.5973261826894, 376.86767147880437

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
327.96303453288976, 1070.4363979825475
441.5973261826894, 376.86767147880437

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
334.54176564920544, 1076.2403148944388
428.4398639500582, 365.259837655022

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
650.3208592323579, 1225.2075156329802
27.588574581586716, 23.502382061968852

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
577.9548169528853, 1333.5472979882834
78.12243200624857, 66.55158058968624

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
327.96303453288976, 1070.4363979825475
441.5973261826894, 376.86767147880437

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1062.5, 888.0
51.522664709120946, 71.89209029179665

IKK-alpha {p}: IKK-beta {p}: IKK-gamma

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1 p82

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
432.04503961702045, 1237.9132771045226
13.984738461093613, 6.3363872374537

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
431.57804961486136, 1219.0166709269633
47.86647522130621, 81.07962418045791

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
451.6586197077024, 1271.751385841083
7.471840034545353, 7.031295321882526

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
469.0, 1384.0
45.674740484429066, 24.3598615916955

IRAK-2c

--

e63

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p35

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
187.5, 1208.0
32.923481692611276, 63.72286779215085

LPS: TLR4

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p36

p2 p35 p39 p41 p43 p45 p46 p71 p74

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
675.5, 152.0
47.40057005042753, 91.7430388072791

IL-1: IL-1RI: MyD88s

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p38

p10

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
484.0, 1263.0
48.73702422145329, 25.993079584775085

MyD88s

--

e67

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p39

p40

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
568.0, 1011.5
40.30589655866372, 24.855302877842625

SOCS1

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

p42

p2 p43 p45 p46

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
308.0, 1012.0
39.117647058823536, 23.470588235294123

NO2-

--

e69

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p43

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
170.73988754208818, 178.60709083039106
1016.5778355652128, 1355.5337769727153

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
347.0, 559.0
26.0, 26.0

Ubiquitin

--

e70

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p48

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
630.0, 974.5
43.03481585832159, 26.538136445964987

P38 {p}

--

e71

cso30:c:Protein

cso30:i:CC_Cytosol

--

p46

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
368.5, 1512.0
34.61335676625659, 53.25131810193321

TLR6: TLR2

--

e72

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p47

p50

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
340.5, 668.0
38.86685552407932, 47.592067988668546

Uba: ubiquitin

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

p79

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
370.0, 1632.5
39.2, 29.400000000000002

lipoprotein

--

e74

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p50

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
259.0, 671.0
34.0, 34.0

Ubc

--

e75

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51 p53

p79

true true true true

csml-variable:Double

m78

10

false

infinite

0

unit false false false
TRANSPATHMO000019972

--

Go back
425.08, 1524.5
49.44, 37.080000000000005

lipoprotein: TLR6: TLR2

--

e76

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p50

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
294.5, 715.0
34.67805365772371, 42.46292284619229

Ubc: ubiquitin

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p79

p51 p53

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
494.47999999999996, 1595.5
30.560000000000006, 22.92

fagellin

--

e78

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p60

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
188.5, 901.0
30.249560632688926, 46.53778558875219

TLR4{ub}

--

e79

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p51 p52

p56

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
174.37171712815083, 202.53095213122657
975.2152309657606, 1332.5234652992358

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
345.0, 773.0
38.0, 38.0

UBR

--

e80

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51 p53

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
TRANSPATHMO000066437

--

Go back
525.5, 742.0
53.89007157276565, 75.1954487061846

IRF-3 {p}: IRF-3: p300

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p49

p81

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
359.5, 840.0
24.24471724693097, 39.31575769772591

Triad3A

--

e82

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p52 p54

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
178.5, 755.0
31.300527240773288, 48.15465729349736

TLR9{ub}

--

e83

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p53 p54

p55

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
250.0, 587.0
36.065479609419874, 34.863296955772554

TLR9 {degraded}

--

e84

cso30:c:EntityBiological

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p55

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
264.0, 893.0
40.02871912693854, 38.69442848937393

TLR4 {degraded}

--

e85

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p56

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
233.5, 465.0
44.01009359515507, 61.409432923472195

TRAF6: TAK1: TAB2

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p57

p58

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
378.5, 468.0
38.39144797210497, 53.5694622866581

TRAF6: TAK1 {p}: TAB2

--

e87

cso30:c:Complex

cso30:i:CC_Cytosol

--

p58

p1

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
557.72, 1523.5
40.00000000000001, 30.000000000000007

flagellin

--

e88

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p60

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
99.0, 549.0
45.24896265560166, 12.066390041493776

bacterial DNA

--

e89

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p61

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
184.05659602431757, 226.45481343206205
970.762838497307, 1315.0477539520045

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
182.5, 521.0
31.0, 60.0

bacterial DNA: TLR9

--

e90

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p61

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
747.0, 1662.0
46.14802354920101, 26.15054667788057

R848

--

e91

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p62 p63

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
618.5, 1516.0
23.870203902652925, 46.20039465029599

R848: TLR7

--

e92

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p62

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
889.5, 1507.0
24.577066432799825, 47.56851567638675

R848: TLR8

--

e93

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p63

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
744.0, 1620.5
52.47600767754319, 28.861804222648754

ssRNA

--

e94

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p64 p65

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
724.5, 1510.0
26.106336329752246, 50.52839289629467

ssRNA: TLR7

--

e95

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p64

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
781.5, 1498.0
25.909230431922822, 50.146897610173205

ssRNA: TLR8

--

e96

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p65

--

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
495.0, 593.5
49.60000000000001, 37.2

IRF-3 {p}: IRF-3

--

e97

cso30:c:Protein

cso30:i:CC_Cytosol

--

p31

p68 p49

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
455.5, 752.0
56.715177096714996, 79.13745641402092

IRF-3 {p}: IRF-3: CBP

--

e98

cso30:c:Complex

cso30:i:CC_Cytosol

--

p68

p69

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
410.5, 1134.0
43.0, 60.0

IRF-3 {p}: IRF-3: CBP{nucleus}

--

e99

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p69

p70

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
995.0, 920.0
30.0, 30.0

p1

p1

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e5 e87

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c186 : 1
stoichiometry:c2 : 1

m5*m90*0.1

nodelay

--

true

0

false

PMID: 15662540 Activation of the IKK complex involves the phosphorylation of two serine residues located in the activation loop within the kinase domain of IKK¦Á (S176 and S180) or IKK¦Â (S177 and S181). PMID: 15662540 Once activated, TAK1 can directly phosphorylate IKK¦Â and mitogen-activated protein kinase kinase 6. PMID: 15662540 TRAF6-TAK1-TAB2 are then translocated to the cytosol, where TAK1 is phosphorylated and activated, leading to the activation of IKK and NF¦ÊB.

Go back
831.0, 260.0
30.0, 30.0

p10

p10

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e17 e66

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c118 : 1
stoichiometry:c26 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 15662540 During the formation of Complex I IRAK4 is activated, leading to the hyperphosphorylation of IRAK. PMID: 15662540 Unlike MyD88, MyD88s does not bind IRAK4, and overexpression of MyD88s does not induce IRAK phosphorylation.

Go back
1075.0, 224.0
30.0, 30.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000041419 e18

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m19287*m18*0.1

nodelay

--

true

0

false

PMID: 15662540, 12496252 During the formation of Complex I IRAK4 is activated, leading to the hyperphosphorylation of IRAK, which creates an interface for its interaction with adapter Pellino 1.

Go back
1139.0, 260.0
30.0, 30.0

p12

p12

cso30:i:ME_Dissociation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e20 MO000016569

e21 e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c98 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15662540 The formation of Pellino 1-IRAK4-IRAKTRAF6 causes conformational changes in the receptor complex (Complex I), releasing these signaling molecules from the receptor. PMID: 15662540 IRAKM prevents the dissociation of the IRAK-IRAK4 from MyD88 thereby inhibiting the formation of the IRAK-TRAF6 interaction.

Go back
1163.0, 428.0
30.0, 30.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e21 MO000016574 MO000016588 MO000022125

e22 e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c41 : 1

m21*m1573*m1583*m6433*0.1

nodelay

--

true

0

false

PMID: 15662540 The released components then interact with the membrane-bound preassociated transforming growth factor ¦Â activated kinase (TAK) 1?transforming growth factor ¦Â activated protein kinase 1 binding protein (TAB) 1?TAB2 [28], resulting in the formation of Complex II (IRAK-TRAF6-TAK1-TAB1-TAB2).

Go back
1241.0, 593.0
30.0, 30.0

p14

p14

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 15662540 TAK1 and TAB2 are phosphorylated in the membrane-bound Complex II.

Go back
1055.0, 572.0
30.0, 30.0

p15

p15

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e23

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 15662540 TAK1 and TAB2 are phosphorylated in the membrane-bound Complex II, triggering the dissociation and translocation of TRAF6-TAK1-TAB1-TAB2 (Complex III) from the membrane to the cytosol.

Go back
933.0, 717.0
30.0, 30.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e35

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c61 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 15662540 The translocated Complex III interacts with additional factors in the cytosol, leading to TAK1 activation. PMID: 15662540 The activation of TAK1 eventually leads to the activation of IKK. PMID: 15662540 Furthermore, it was shown that the TAK1 complex (TAK1-TAB1-TAB2) is activated by association with ubiquitinated TRAF6.

Go back
928.0, 319.0
30.0, 30.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 MO000009093

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m183*m1116*0.1

nodelay

--

true

0

false

PMID: 15662540 It has been shown that MEKK3 forms a complex with TRAF6 in response to IL-1 and is crucial for IL-1 induced NF¦ÊB activation.

Go back
825.0, 769.0
30.0, 30.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c50 : 1
stoichiometry:c52 : 1

m29*m28*0.1

nodelay

--

true

0

false

PMID: 15662540 Once activated, TAK1 can directly phosphorylate IKK¦Â and mitogen-activated protein kinase kinase 6, leading to the activation of both the c-Jun N-terminal kinase and NF¦ÊB signaling pathways.

Go back
757.0, 841.0
30.0, 30.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c55 : 1
stoichiometry:c54 : 1

m31*m30*0.1

nodelay

--

true

0

false

PMID: 15662540 Activated TAK1 has also been implicated in the IL-1 induced activation of mitogen-activated protein kinase kinase 6 and c-Jun N-terminal kinase [46], leading to the activation of other transcription factors, including activating transcription factor and activator protein 1.

Go back
1003.0, 1008.0
30.0, 30.0

p2

p2

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000233 e6 e64 e68

MO000000220

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c5 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c4 : 1

m199*m6*m66*0.1

nodelay

--

true

0

false

PMID: 15662540 The IKK¦Á and IKK¦Â subunits preferentially form heterodimers, and both can directly phosphorylate the critical S32 and S36 residues of I¦ÊB¦Á. PMID: 15662540 LPS-induced I¦ÊB and p38 phosphorylation are upregulated in SOCS1- deficient macrophages. Moreover, forced expression of SOCS1 suppresses LPS-induced NF¦ÊB activation.

Go back
705.0, 789.0
30.0, 30.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000276 e29

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c58 : 1
stoichiometry:c57 : 1

m219*m30*0.1

nodelay

--

true

0

false

PMID: 15662540 Activated TAK1 has also been implicated in the IL-1 induced activation of mitogen-activated protein kinase kinase 6 and c-Jun N-terminal kinase [46], leading to the activation of other transcription factors, including activating transcription factor and activator protein 1.

Go back
893.0, 573.0
30.0, 30.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 MO000022136 e34

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c44 : 1
stoichiometry:c62 : 1
stoichiometry:c59 : 1

m25*m6443*m35*0.1

nodelay

--

true

0

false

PMID: 15662540 TRAF6 functions as part of a unique E3 complex, with Ubc13 and Uev1A, and TRAF6 itself is the target of ubiquitination.

Go back
1061.0, 725.0
30.0, 30.0

p22

p22

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e33

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c63 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 15662540 TRAF6 functions as part of a unique E3 complex, with Ubc13 and Uev1A, and TRAF6 itself is the target of ubiquitination.

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893.0, 705.0
30.0, 30.0

p23

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e27 e26

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c49 : 1
stoichiometry:c48 : 1

m27*m26*0.1

nodelay

--

true

0

false

PMID: 15662540 Once activated, TAK1 can directly phosphorylate IKK¦Â and mitogen-activated protein kinase kinase 6.

Go back
909.0, 1145.0
30.0, 30.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e39 e48 e47 e46

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c104 : 1
stoichiometry:c106 : 1
stoichiometry:c246 : 1
stoichiometry:c102 : 1

m41*m63*0.1

nodelay

--

true

0

false

PMID: 15662540 When over expressed, IRAK2a and IRAK2b potentiate NF¦ÊB activation by LPS. Interestingly, IRAK2c and IRAK2d were inhibitory.

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304.0, 111.0
30.0, 30.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 15662540, 11607032 TLR3 recognizes doublestranded RNA (dsRNA).

Go back
304.0, 227.0
30.0, 30.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c75 : 1
stoichiometry:c72 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 15662540, 12872135, 12855817 TRIF was recently identified as an adapter for TLR3.

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317.0, 285.0
30.0, 30.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041437 MO000000212 MO000022125 MO000016574

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c74 : 1

m19305*m183*m6433*m1573*0.1

nodelay

--

true

0

false

PMID: 15662540 adapter molecule TRIF recruits TRAF6?TAK1?TAB2 to TLR3 through its TRAF6-binding site.

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99.0, 336.0
30.0, 30.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 MO000000065

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m38*m39*0.1

nodelay

--

true

0

false

PMID: 15662540 receptor interacting protein (RIP) 1 has also been implicated in TLR3/TRIFmediated NF¦ÊB activation.

Go back
949.0, 1141.0
30.0, 30.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e39 e38 e46 e47

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c84 : 1
stoichiometry:c107 : 1
stoichiometry:c243 : 1
stoichiometry:c83 : 1

m41*m40*0.1

nodelay

--

true

0

false

PMID: 15662540 it is possible that RIP1 directly cooperates with the TRAF6-containing complex, facilitating the NF¦ÊB activation process. PMID: 15662540 When over expressed, IRAK2a and IRAK2b potentiate NF¦ÊB activation by LPS. Interestingly, IRAK2c and IRAK2d were inhibitory.

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1007.0, 1064.0
30.0, 30.0

p3

p3

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000000220

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1

m190*0.1

nodelay

--

true

0

false

PMID: 15662540 Phospho-I¦ÊB is then recognized by the ¦Â-transducin repeat containing protein containing Skp1/Cullin/F-box ubiquitin ligase complex, leading to its ubiquitination and degradation by the proteasome.

Go back
369.0, 289.0
30.0, 30.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e41 e105

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c89 : 1
stoichiometry:c86 : 1

m43*m108*0.1

nodelay

--

true

0

false

PMID; 15662540 TRIF leads to the activation of TBK1/IKK¦Å, resulting in IRF3 activation.

Go back
585.0, 549.0
30.0, 30.0

p31

p31

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e40

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c206 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 15662540 Viral infection and Toll ligands (dsRNA and LPS) lead to the phosphorylation of IRF3 and its subsequent dimerization.

Go back
963.0, 236.0
30.0, 30.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066718 e18

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c91 : 1
stoichiometry:c93 : 1

m41575*m18*0.1

nodelay

--

true

0

false

PMID:15662540, 12925853 The fact that SIGIRR forms a complex with the IL-1 receptor, IRAK, and TRAF6 upon IL-1 stimulation suggests that SIGIRR functions through its interaction with the TIR complex.

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539.0, 316.0
30.0, 30.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000022528 MO000044786

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m1572*m6810*m22456*0.1

nodelay

--

true

0

false

PMID: 15662540 Overexpression of ST2 was found to inhibit NF¦ÊB activation because ST2 associated with, and probably sequestered, MyD88 and TIRAP.Overexpression of ST2 was found to inhibit NF¦ÊB activation because ST2 associated with, and probably sequestered, MyD88 and TIRAP.

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865.0, 1149.0
30.0, 30.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e39 e49 e47 e46

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c103 : 1
stoichiometry:c105 : 1
stoichiometry:c247 : 1
stoichiometry:c101 : 1

m41*m64*0.1

nodelay

--

true

0

false

PMID: 15662540 When over expressed, IRAK2a and IRAK2b potentiate NF¦ÊB activation by LPS. Interestingly, IRAK2c and IRAK2d were inhibitory.

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413.0, 1369.0
30.0, 30.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e64

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 15662540 LPS induces the expression of IRAK2c.

Go back
121.0, 949.0
30.0, 30.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 15662540 LPS induces the expression of IRAK2c.

Go back
476.0, 263.0
30.0, 30.0

p37

p37

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000016573

MO000050640

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c113 : 1

m1572*0.1

nodelay

--

true

0

false

PMID: 15662540 MyD88 forms homodimers through DD-DD and TIR-TIR domain interactions and exists as a dimer when recruited to the receptor complex.

Go back
603.0, 256.0
30.0, 30.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000016573

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c46 : 1
stoichiometry:c117 : 1

m15*m1572*0.1

nodelay

--

true

0

false

PMID: 15662540 Unlike MyD88, MyD88s does not bind IRAK4, and overexpression of MyD88s does not induce IRAK phosphorylation.

Go back
421.0, 1253.0
30.0, 30.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e64

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 15662540 MyD88s is induced in monocytes upon LPS stimulation.

Go back
1061.0, 1209.0
30.0, 30.0

p4

p4

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e12

e13 e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 15662540 Phospho-I¦ÊB is then recognized by the ¦Â-transducin repeat containing protein containing Skp1/Cullin/F-box ubiquitin ligase complex, leading to its ubiquitination and degradation by the proteasome.

Go back
545.0, 897.0
30.0, 30.0

p40

p40

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e67

MO000016573

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c116 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 15662540 MyD88s is induced in monocytes upon LPS stimulation.

Go back
437.0, 1289.0
30.0, 30.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e64

G010539

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 15662540 LPS induces the expression of SOCS1 in macrophages.

Go back
653.0, 1041.0
30.0, 30.0

p42

p42

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010539

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m93501*0.1

nodelay

--

true

0

false

PMID: 15662540 LPS induces the expression of SOCS1 in macrophages.

Go back
313.0, 1077.0
30.0, 30.0

p43

p43

cso30:i:ME_ChangeInMaterialConcentration

cso30:i:CC_Cytosol

--

e64 e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c129 : 1
stoichiometry:c128 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 15662540 LPS-induced NO2¡Ý synthesis and tumor necrosis factor ¦Á production are augmented in SOCS1- deficient macrophages.

Go back
731.0, 1372.0
30.0, 30.0

p44

p44

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 15662540 LPS-induced NO2¡Ý synthesis and tumor necrosis factor ¦Á production are augmented in SOCS1- deficient macrophages.

Go back
477.0, 1341.0
30.0, 30.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e64 e68

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c134 : 1
stoichiometry:c131 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 15662540 LPS-induced NO2¡Ý synthesis and tumor necrosis factor ¦Á production are augmented in SOCS1- deficient macrophages.

Go back
573.0, 933.0
30.0, 30.0

p46

p46

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 e64 e68

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c138 : 1

m72*m66*0.1

nodelay

--

true

0

false

PMID: 15662540 LPS-induced I¦ÊB and p38 phosphorylation are upregulated in SOCS1- deficient macrophages.

Go back
315.0, 1592.0
30.0, 30.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000019422

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c146 : 1

m3964*m3987*0.1

nodelay

--

true

0

false

PMID: 15662540, 11095740 TLR6 associates with TLR2 and recognizes lipoproteins from microplasma.

Go back
345.0, 617.0
30.0, 30.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e70 MO000018944

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c145 : 1

m73*m3556*0.1

nodelay

--

true

0

false

PMID: 15662540 In an initial step the ubiquitin-activating enzyme (E1 or Uba) forms a thioester bond with the C-terminus of ubiquitin.

Go back
537.0, 673.0
30.0, 30.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019984 e97

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c167 : 1
stoichiometry:c209 : 1

m4512*m100*0.1

nodelay

--

true

0

false

PMID: 15662540 Viral infection and Toll ligands (dsRNA and LPS) lead to the phosphorylation of IRF3 and its subsequent dimerization and interaction with the coactivaotors cAMP-response element binding protein binding protein and p300.

Go back
480.0, 99.0
30.0, 30.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000214 MO000016595

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m185*m1589*0.1

nodelay

--

true

0

false

PMID: 15662540 The Ig domain subgroup includes IL-1 receptor (IL-1R) 1.

Go back
435.0, 1596.0
30.0, 30.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e72 e74

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c153 : 1

m75*m77*0.1

nodelay

--

true

0

false

PMID: 15662540, 11095740 TLR6 associates with TLR2 and recognizes lipoproteins from microplasma.

Go back
281.0, 845.0
30.0, 30.0

p51

p51

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000019394 e77 e80

e79 e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c161 : 1
stoichiometry:c160 : 1
stoichiometry:c178 : 1

m3961*m80*m83*0.1

nodelay

--

true

0

false

PMID:15662540 In the final step the E2 enzyme donates ubiquitin to a lysine residue of the target protein, either directly or with the assistance of ubiquitin protein ligase (E3 or Ubr).

Go back
317.0, 909.0
30.0, 30.0

p52

p52

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000019394 e82

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c163 : 1
stoichiometry:c159 : 1

m3961*m85*0.1

nodelay

--

true

0

false

PMID: 15662540 Triad3A overexpression promoted substantial degradation of TLR4 and TLR9.

Go back
239.0, 736.0
30.0, 30.0

p53

p53

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e77 e80 MO000042012

e83 e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c177 : 1

m80*m83*m19828*0.1

nodelay

--

true

0

false

PMID:15662540 In the final step the E2 enzyme donates ubiquitin to a lysine residue of the target protein, either directly or with the assistance of ubiquitin protein ligase (E3 or Ubr).

Go back
243.0, 792.0
30.0, 30.0

p54

p54

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e82 MO000042012

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m85*m19828*0.1

nodelay

--

true

0

false

PMID: 15662540 Triad3A overexpression promoted substantial degradation of TLR4 and TLR9.

Go back
117.0, 653.0
30.0, 30.0

p55

p55

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Extracellular

--

e83

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 15662540 Triad3A overexpression promoted substantial degradation of TLR4 and TLR9.

Go back
113.0, 849.0
30.0, 30.0

p56

p56

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Extracellular

--

e79

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1

m82*0.1

nodelay

--

true

0

false

PMID: 15662540 Triad3A overexpression promoted substantial degradation of TLR4 and TLR9.

Go back
237.0, 389.0
30.0, 30.0

p57

p57

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e37

e86 MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 15662540 TRAF6-TAK1-TAB2 are then translocated to the cytosol.

Go back
303.0, 480.0
30.0, 30.0

p58

p58

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m89*0.1

nodelay

--

true

0

false

PMID: 15662540 TRAF6-TAK1-TAB2 are then translocated to the cytosol, where TAK1 is phosphorylated and activated.

Go back
753.0, 1193.0
30.0, 30.0

p6

p6

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e11

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 15662540, 10837071, 10713156 The destruction of I¦ÊB unmasks the nuclear localization signal of NF¦ÊB, leading to its nuclear translocation and binding to the promoters of target genes.

Go back
563.0, 1592.0
30.0, 30.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

MO000019399 e78

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c156 : 1
stoichiometry:c166 : 1

m3966*m81*0.1

nodelay

--

true

0

false

PMID: 15662540, 11323673 While TLR5 mediates the induction of the immune response by bacterial flagellins.

Go back
121.0, 589.0
30.0, 30.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e89

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c189 : 1

m19828*m92*0.1

nodelay

--

true

0

false

PMID: 15662540, 11130078 TLR9 has been shown to recognize bacterial DNA.

Go back
607.0, 1592.0
30.0, 30.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1

m19940*m94*0.1

nodelay

--

true

0

false

PMID: 15662540, 11812998, 10346978 While a synthetic compound (imidazoquinoline compound R848) with antiviral activity has been described as a ligand for TLR7 and TLR8.

Go back
879.0, 1588.0
30.0, 30.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e91 MO000042007

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c194 : 1
stoichiometry:c195 : 1

m94*m19823*0.1

nodelay

--

true

0

false

11812998, 10346978 While a synthetic compound (imidazoquinoline compound R848) with antiviral activity has been described as a ligand for TLR7 and TLR8.

Go back
687.0, 1588.0
30.0, 30.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e94 MO000042126

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m97*m19940*0.1

nodelay

--

true

0

false

PMID: 15662540, 14976261, 14976262, 15034168 recent studies showed that ssRNA is the natural ligand for TLR7/8.

Go back
811.0, 1592.0
30.0, 30.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e94 MO000042007

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c200 : 1
stoichiometry:c201 : 1

m97*m19823*0.1

nodelay

--

true

0

false

PMID: 15662540, 14976261, 14976262, 15034168 recent studies showed that ssRNA is the natural ligand for TLR7/8.

Go back
1005.0, 1137.0
30.0, 30.0

p66

p66

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e39 e36 e47 e46

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c204 : 1
stoichiometry:c244 : 1
stoichiometry:c245 : 1
stoichiometry:c203 : 1

m41*m37*0.1

nodelay

--

true

0

false

PMID: 15662540 It has been shown that MEKK3 forms a complex with TRAF6 in response to IL-1 and is crucial for IL-1 induced NF¦ÊB activation.

Go back
445.0, 453.0
30.0, 30.0

p67

p67

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e42 e43

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c90 : 1

m44*m45*0.1

nodelay

--

true

0

false

PMID; 15662540 TRIF leads to the activation of TBK1/IKK¦Å, resulting in IRF3 activation. PMID: 15662540 Viral infection and Toll ligands (dsRNA and LPS) lead to the phosphorylation of IRF3 and its subsequent dimerization.

Go back
473.0, 673.0
30.0, 30.0

p68

p68

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e97 MO000017462

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c208 : 1
stoichiometry:c210 : 1

m100*m2282*0.1

nodelay

--

true

0

false

PMID: 15662540 Viral infection and Toll ligands (dsRNA and LPS) lead to the phosphorylation of IRF3 and its subsequent dimerization and interaction with the coactivaotors cAMP-response element binding protein binding protein and p300.

Go back
417.0, 885.0
30.0, 30.0

p69

p69

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e98

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c212 : 1

m101*0.1

nodelay

--

true

0

false

PMID: 15662540 The IRF3 complex then translocates to the nucleus.

Go back
536.0, 175.0
30.0, 30.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 MO000050640

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c114 : 1
stoichiometry:c18 : 1

m15*m192928*0.1

nodelay

--

true

0

false

PMID: 15662540 Upon IL-1 stimulation adapter molecule MyD88 is first recruited to the IL-1 receptor.

Go back
485.0, 1177.0
30.0, 30.0

p70

p70

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e99

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c213 : 1

m102*0.1

nodelay

--

true

0

false

PMID: 15662540 The IRF3 complex then translocates to the nucleus, where it activates promoters containing IRF-binding sites.

Go back
117.0, 1249.0
30.0, 30.0

p71

p71

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016573 e64

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c217 : 1
stoichiometry:c218 : 1

m1572*m66*0.1

nodelay

--

true

0

false

PMID: 15662540, 10435584 TLR4-mediated NF¦ÊB activation was greatly reduced in MyD88- deficient mice, indicating the requirement of MyD88 for TLR4 signaling.

Go back
117.0, 1345.0
30.0, 30.0

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022528 e102

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c220 : 1
stoichiometry:c221 : 1

m6810*m105*0.1

nodelay

--

true

0

false

PMID: 15662540, 12447442, 12447441 Interestingly, TIRAP-deficient mice showed defects in activation of the MyD88-dependent signaling pathway through TLR4, but not IL-1R, indicating specificity of the TLR4-mediated MyD88-dependent pathway.

Go back
817.0, 1149.0
30.0, 30.0

p73

p73

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e39 e103 e47 e46

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c224 : 1
stoichiometry:c242 : 1
stoichiometry:c248 : 1
stoichiometry:c223 : 1

m41*m106*0.1

nodelay

--

true

0

false

PMID: 15662540 LPS-induced, TLR4-mediated signaling employs multiple TIR-domain containing adaptors, MyD88/TIRAP to mediate NF¦ÊB activation.

Go back
105.0, 1025.0
30.0, 30.0

p74

p74

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041125 e64

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c226 : 1
stoichiometry:c227 : 1

m18998*m66*0.1

nodelay

--

true

0

false

PMID: 15662540, 12855817 Such TLR4-mediated MyD88-independent activities were abolished in TRIF-deficient mice.

Go back
105.0, 1085.0
30.0, 30.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e104 MO000041132

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1
stoichiometry:c230 : 1

m107*m19005*0.1

nodelay

--

true

0

false

PMID: 15662540 TLR4- but not TLR3-mediated MyD88-independent IRF3 activation and interferon ¦Â production was abolished in TRAM-deficient mice.

Go back
377.0, 1213.0
30.0, 30.0

p76

p76

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e105

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c232 : 1
stoichiometry:c231 : 1

m108*0.1

nodelay

--

true

0

false

PMID: 15662540 LPS still stimulates the expression of certain genes, including interferon ¦Â, in MyD88- deficient mice.

Go back
445.0, 505.0
30.0, 30.0

p77

p77

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e43 e101

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c215 : 1
stoichiometry:c234 : 1

m45*m104*0.1

nodelay

--

true

0

false

PMID: 15662540 Recently the IKK-related kinases IKK¦Å and TRAF family member associated NF¦ÊB activator binding kinase binding kinase 1 have been implicated in the phosphorylation and activation of IRF3.

Go back
449.0, 557.0
30.0, 30.0

p78

p78

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e43 e105

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c237 : 1
stoichiometry:c236 : 1

m45*m108*0.1

nodelay

--

true

0

false

PMID: 15662540 LPS-induced, TLR4-mediated signaling employs multiple TIR-domain containing adaptors, MyD88/TIRAP to mediate NF¦ÊB activation, TRIF/TRAM for IRF3 activation.

Go back
297.0, 621.0
30.0, 30.0

p79

p79

cso30:i:ME_Transference

cso30:i:CC_Cytosol

--

e73 e75

e77 MO000018944

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c151 : 1
stoichiometry:c152 : 1

m76*m78*0.1

nodelay

--

true

0

false

PMID: 15662540 In an initial step the ubiquitin-activating enzyme (E1 or Uba) forms a thioester bond with the C-terminus of ubiquitin, which is then transferred to a specific cysteine residue of an ubiquitinconjugating enzyme (E2 or Ubc).

Go back
735.0, 140.0
30.0, 30.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000213 MO000039077 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m184*m17258*m16*0.1

nodelay

--

true

0

false

PMID: 15662540, 11960013, 8599092 Upon IL-1 stimulation adapter molecule MyD88 is first recruited to the IL-1 receptor, followed by the recruitment of two serine-threonine kinases, IRAK4 and IRAK.

Go back
569.0, 1125.0
30.0, 30.0

p80

p80

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e106

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c239 : 1

m109*0.1

nodelay

--

true

0

false

PMID: 15662540 The IRF3 complex then translocates to the nucleus, where it activates promoters containing IRF-binding sites.

Go back
485.0, 881.0
30.0, 30.0

p81

p81

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e81

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c241 : 1

m84*0.1

nodelay

--

true

0

false

PMID: 15662540 The IRF3 complex then translocates to the nucleus.

Go back
997.0, 841.0
30.0, 30.0

p1

p82

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e5 e26

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c251 : 1
stoichiometry:c250 : 1

m5*m26*0.1

nodelay

--

true

0

false

PMID: 15662540 Activation of the IKK complex involves the phosphorylation of two serine residues located in the activation loop within the kinase domain of IKK¦Á (S176 and S180) or IKK¦Â (S177 and S181). PMID: 15662540 Once activated, TAK1 can directly phosphorylate IKK¦Â and mitogen-activated protein kinase kinase 6. PMID: 15662540 TRAF6-TAK1-TAB2 are then translocated to the cytosol, where TAK1 is phosphorylated and activated, leading to the activation of IKK and NF¦ÊB.

Go back
911.0, 172.0
30.0, 30.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000212 e19

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c27 : 1
stoichiometry:c25 : 1

m183*m19*0.1

nodelay

--

true

0

false

PMID: 15662540, 8837778 Upon IL-1 stimulation adapter molecule MyD88 is first recruited to the IL-1 receptor, followed by the recruitment of two serine-threonine kinases, IRAK4 and IRAK and the adapter TNF receptor associated factor (TRAF) 6.

Go back
1025.8406661402685, 870.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
803.3387600887686, 1105.1847449441825

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
887.8311367793272, 1112.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
802.6564023547028, 1112.437601569802

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
803.3158220461108, 1106.2370894009339

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.1950639396376, 1186.9976215251445

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
924.0, 1183.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
889.8071310417222, 1182.5685119304892

c105

c105

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
929.0381621315169, 1178.862928861458

c106

c106

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
972.6160620938771, 1174.6590085144385

c107

c107

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
220.0, 1251.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
443.0, 1386.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.0, 114.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
99.0, 965.7242859683402

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
158.99001871102277, 965.3995009355511

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
140.0, 979.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
506.0, 278.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
551.0, 213.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.0, 199.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
494.9364278338949, 361.9450049032022

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
633.0, 224.37451950788653

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
723.0, 210.0

c118

c118

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
220.0, 1242.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
768.3114520150781, 1116.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.0, 1270.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
510.0, 934.9195959492894

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
220.0, 1244.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
467.0, 1306.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
589.0, 1078.6335341008792

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
615.4278135270821, 1034.9711254108329

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
220.0, 1113.1235033136995

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
328.0, 1043.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
346.8691876719378, 1029.0

c129

c129

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
736.3000400080607, 1219.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
220.0, 1247.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
507.0, 1359.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.0, 1381.0

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
761.0, 1387.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.108866310802, 1036.0

c134

c134

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
220.0, 1029.0631443728

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
608.0, 1023.0101265498269

c136

c136

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
610.7748008455096, 936.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
603.0, 957.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
220.0, 963.837461886556

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
451.0, 135.24695047554425

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 967.0

c140

c140

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
360.0, 585.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
326.0, 592.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
282.0, 1557.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
327.0, 1557.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.0, 647.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
343.0, 1567.1295323450063

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
330.31491071063937, 656.9792745494693

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
287.0, 657.5538553641524

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
403.0, 1559.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 129.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
409.0, 1623.9977796279165

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.0, 651.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
312.0, 600.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
450.0, 1570.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.0, 1555.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
225.0, 931.7010587965503

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
525.0, 1607.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.0, 881.198920166175

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.9922778767137, 757.0

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
227.0, 924.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
517.0, 187.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
225.5737182247253, 871.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
316.65685424949237, 811.0

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
565.3701422443754, 650.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
345.2804166494748, 879.0

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
276.72492606816536, 740.0

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
276.50674493453687, 759.7656428706189

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
578.0, 1562.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.0, 631.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.26855788238674, 817.3418656930513

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
219.0, 713.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
491.3330443576975, 300.9930645847388

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
217.20441309091663, 758.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
212.0, 713.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
217.36465425500205, 789.1243987748494

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
143.88514344942905, 689.9932582089723

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
147.0, 615.4367458644506

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
149.30004000806068, 880.9304660932648

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
143.0, 869.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
259.0, 712.5394219638499

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
123.77455248897604, 704.4998292861418

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
151.73090930902015, 625.4512399668456

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.0, 190.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
124.0, 561.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
212.0, 341.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.0, 419.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
252.0, 227.99873983774629

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
278.0, 495.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
333.0, 495.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
396.187693338555, 522.0

c186

c186

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
151.0, 569.1589675136782

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
726.0, 177.79663720863564

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
640.0856580228888, 1558.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
644.2829318197008, 1617.3104235544095

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
624.0, 1569.9602975216799

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
793.0, 1616.0209636589962

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
861.0, 1553.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.0, 1562.9418702562696

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.2080133580728, 1613.4705249501833

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.0, 1558.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
710.0, 1567.9932582089723

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.0, 1617.383083722649

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1025.0, 929.0436361005711

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
754.8178369248513, 177.79072967793434

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.5298221281347, 1553.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
805.8831942336172, 1555.4623850752448

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.0, 1102.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
803.7804480391335, 1099.8613512055342

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
960.0, 403.0

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
564.0, 554.0

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
551.8599434057004, 573.0

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.15135438863337, 631.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.0, 660.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 703.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
644.0, 161.04013030154562

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
485.3262589561145, 703.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
442.4705249501832, 831.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 915.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.0, 1192.0

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
454.0, 1172.0

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
482.78416844149837, 493.0

c215

c215

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
47.695081278646285, 327.92543692083814

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
154.57079884854397, 1245.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
145.0, 1279.0

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
150.20770212727035, 422.0

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
765.0, 163.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
154.80949648147163, 1348.0

c220

c220

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
147.0, 1371.0

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.6568542494924, 1112.0

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
797.1758195855608, 1122.1000730829824

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
228.0, 1186.9999908752418

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
116.30145565783806, 245.0

c225

c225

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
129.12810604126045, 1062.3630803740439

c226

c226

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
135.0, 1039.1379105380067

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
141.53261998627156, 1049.0

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
142.9895013078127, 1101.4097180157853

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.0, 238.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
135.0, 1108.0

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
407.0, 1228.0

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
224.0, 1155.0

c232

c232

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
481.37673718523206, 484.0

c233

c233

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.0, 525.0

c234

c234

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
477.2311430915081, 488.0

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
479.0, 556.3765324210899

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
224.0, 594.8076242022203

c237

c237

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.0, 1134.0

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
579.3151918984429, 1155.0

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
901.0, 209.56298385301017

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
510.2065506721577, 817.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.0, 911.0

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
845.4388430433987, 1182.1704959564183

c242

c242

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
965.2434502818022, 1174.9925846215567

c243

c243

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
980.0, 1170.906382592451

c244

c244

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1021.3215367596813, 1170.9870558200473

c245

c245

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
937.3642486500619, 1178.2265040400844

c246

c246

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
897.8999977343776, 1180.7549978476588

c247

c247

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
850.245770875785, 1177.3377278331548

c248

c248

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1034.7012075212313, 843.0

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 179.77296882871175

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1027.0, 869.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
944.0, 826.0

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
850.0, 227.76114000116266

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
893.0, 180.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1050.0, 249.46184854067818

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.0, 190.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1040.951069877389, 1017.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1101.0, 201.47953697234416

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1152.0, 209.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1155.0, 290.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.020205322511, 82.37182571564571

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1167.0, 377.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1111.0, 399.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1103.0, 433.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1105.0, 450.2501634822136

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1169.1119090269774, 458.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1194.0, 576.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1033.0, 1035.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1201.8993262705642, 617.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1092.4299365221098, 454.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1091.1916583936265, 604.0659023220582

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1003.5326199862716, 540.6178865420195

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
908.0, 531.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
926.2289589627687, 551.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
510.0, 282.66914335816205

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.0, 669.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
865.9869706753918, 721.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
909.2423130131261, 742.996329433163

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1033.6241387262428, 960.0

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.0, 737.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.0, 807.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
799.7748008455096, 787.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
793.567241614284, 871.5685159055888

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
777.0, 871.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
772.0, 820.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
689.0, 811.8089875327071

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.0, 819.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
742.9861949854, 802.0

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
923.0, 595.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1045.0, 1079.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1075.0, 705.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.1513543886333, 747.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.0, 526.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1043.0, 740.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
970.8911513906571, 735.3151918984429

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
910.0, 297.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
899.0, 355.84950128852483

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
942.2498780190218, 349.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
342.0, 126.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.29297309669477, 146.99870284292075

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1037.0, 1094.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
319.0, 141.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
319.0, 208.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
283.5424513544061, 217.6039472493969

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.0, 220.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
231.97056446268277, 301.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
342.0, 242.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
161.62608684092487, 61.752201008884015

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.29687165323605, 25.995552167454832

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
122.3550494256022, 9.770463939292199

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
136.11430241854518, 326.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1079.0436361005711, 1171.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
136.98318690083843, 352.51838875979473

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
129.0, 362.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
927.0, 1112.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
803.5894663844041, 1102.5298221281348

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
78.28681036488956, 416.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
401.0659023220581, 325.19165839362654

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
385.0, 319.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
415.0, 441.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
483.0, 468.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
214.0, 326.83078172633367

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1078.0, 1239.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
475.0, 482.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
979.6643638388299, 224.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.0, 266.57745276819264

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
993.0, 187.05141074567655

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
510.0, 332.823193208684

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
576.1919189506982, 341.5037553862376

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
577.0, 331.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.0, 346.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1017.0, 283.7068018961654

c98

c98

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
913.0, 1112.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back