_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e4
_enti_e2
_enti_e3
_enti_e55
_enti_e53
_enti_e59
_enti_e52
_enti_e50
_enti_e51
_enti_e54
_enti_e56
_enti_e57
_enti_e58
_enti_e61
_enti_e60
_enti_e62
g1_fact_g1
g1_fact_g14
g2_fact_g12
g2_fact_g13
p1_propro_p2
PMID: 15691589,7528106
For example, moderate NO concentrations
inhibit basal apoptosis in B lymphocytes, apoptosis induced by the potent
cytokine TGF-beta in hepatocytes, and Fas-dependent
apoptosis in several cellular models of inflammation
c2 cso30:c:InputInhibitor connector
c3 cso30:c:InputAssociation connector
p1_propro_p3
PMID: 15691589,7528106
For example, moderate NO concentrations
inhibit basal apoptosis in B lymphocytes, apoptosis induced by the potent
cytokine TGF-beta in hepatocytes, and Fas-dependent
apoptosis in several cellular models of inflammation
c4 cso30:c:InputInhibitor connector
c5 cso30:c:InputAssociation connector
p1_propro_p1
PMID: 15691589,12605597,9733516
These include the
‘desensitization’ of the initial pro-apoptotic signaling
pathway (although the mechanisms of this have been little studied), the inhibition of procaspase processing
and caspase activity and the expression
of anti-apoptotic genes of the Inhibitor of Apoptosis
(IAP) family
c1 cso30:c:InputInhibitor connector
c6 cso30:c:InputProcess connector
c7 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 15691589,12605597,9733516
These include the
‘desensitization’ of the initial pro-apoptotic signaling
pathway (although the mechanisms of this have been little studied), the inhibition of procaspase processing
and caspase activity and the expression
of anti-apoptotic genes of the Inhibitor of Apoptosis
(IAP) family
c8 cso30:c:InputInhibitor connector
c9 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 15691589
Elevated
nitric oxide synthesis after the induced expression
of NOS-2 by activated macrophages is one of the
main cytostatic, cytotoxic, and pro-apoptotic mechanisms
participating in the innate response in many mammals
PMID: 15691589
A process that can be
demonstrated when NO synthesis is suppressed via
treatment of cells with a selective NOS-2 inhibitor such
as N-(3-aminomethylbenzyl)acetamidine (1400 W) or
l-N6-(1-iminoethyl)lysine (l-NIL).
c10 cso30:c:InputAssociation connector
c48 cso30:c:InputInhibitor connector
c49 cso30:c:InputInhibitor connector
c11 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 15691589,11129661
The pro-apoptotic activity of NO has
been well documented and involves the release of cytochrome c from the mitochondria,
increased expression of the tumor suppressor
p53 and accumulation and targeting
of pro-apoptotic members of the Bcl-2 family,
in particular Bax, which is translocated to the mitochondria
c12 cso30:c:InputAssociation connector
c13 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 15691589
In contrast, molecules that release NO
in a sustained way, or induction of NOS-2 expression
by treatment with lipopolysaccharide (LPS) and IFN-
gamma, do not provoke this response
c14 cso30:c:InputAssociation connector
c15 cso30:c:OutputProcess connector
p7_propro_p8
PMID: 15691589
In contrast, molecules that release NO
in a sustained way, or induction of NOS-2 expression
by treatment with lipopolysaccharide (LPS) and IFN-
gamma, do not provoke this response
c17 cso30:c:InputAssociation connector
c16 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 15691589
The active sites of
caspase enzymes contain a cysteine residue that is susceptible
to S-nitrosylation by NO in the procaspase and
active forms of the proteins.
c18 cso30:c:InputProcess connector
c20 cso30:c:InputAssociation connector
c19 cso30:c:OutputProcess connector
p9_propro_p10
PMID: 15691589
The active sites of
caspase enzymes contain a cysteine residue that is susceptible
to S-nitrosylation by NO in the procaspase and
active forms of the proteins.
c21 cso30:c:InputAssociation connector
c22 cso30:c:InputProcess connector
c23 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 15691589
This occurs
through a mechanism that involves nitrosylation of the
proteasome and of the p50 and p65 subunits at their
DNA binding domains; inhibiting their transcriptional
activity.
c24 cso30:c:InputAssociation connector
c25 cso30:c:InputProcess connector
c26 cso30:c:OutputProcess connector
p11_propro_p12
PMID: 15691589
This occurs
through a mechanism that involves nitrosylation of the
proteasome and of the p50 and p65 subunits at their
DNA binding domains; inhibiting their transcriptional
activity.
c27 cso30:c:InputAssociation connector
c28 cso30:c:InputProcess connector
c29 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 15691589,9422508
This potent anti-inflammatory
molecule efficiently inhibits IKappaB kinase (IKK) activation,
as well as the transcriptional activity of several factors such as NF-KappaB, AP-1 and Stat-1alpha
c30 cso30:c:InputAssociation connector
c31 cso30:c:InputProcess connector
c32 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 15691589
Moreover, 15-dPGJ2 synergizes with NO by enhancing
the synthesis of reactive oxygen species, in particular
oxygen superoxide.
c33 cso30:c:InputAssociation connector
c34 cso30:c:InputAssociation connector
c35 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 15691589,11086094,10593878,11175752,12893946,12727142
Superoxide rapidly reacts withNO
to produce peroxynitrite, one of the most potent oxidants
released by cells, and exhibits both pro-apoptotic
and necrotic effects
c36 cso30:c:InputProcess connector
c37 cso30:c:InputProcess connector
c38 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 15691589,10669746,12612088,12524534
These nuclear receptors respectively activated by
fatty acids/prostanoids and oxysterols exert an important
down-regulatory control on the transcriptional activity of pro-inflammatory genes and on transcription
factors such as NF-KappaB, Stat-1alpha, and AP-1
c39 cso30:c:InputProcess connector
c40 cso30:c:InputProcess connector
c41 cso30:c:OutputProcess connector
p16_propro_p17
PMID: 15691589,10669746,12612088,12524534
These nuclear receptors respectively activated by
fatty acids/prostanoids and oxysterols exert an important
down-regulatory control on the transcriptional activity of pro-inflammatory genes and on transcription
factors such as NF-KappaB, Stat-1alpha, and AP-1
c42 cso30:c:InputProcess connector
c43 cso30:c:InputProcess connector
c44 cso30:c:OutputProcess connector
p16_propro_p18
PMID: 15691589,10669746,12612088,12524534
These nuclear receptors respectively activated by
fatty acids/prostanoids and oxysterols exert an important
down-regulatory control on the transcriptional activity of pro-inflammatory genes and on transcription
factors such as NF-KappaB, Stat-1alpha, and AP-1
c45 cso30:c:InputProcess connector
c46 cso30:c:InputProcess connector
c47 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 15691589
Figure 3
c50 cso30:c:InputAssociation connector
c51 cso30:c:InputProcess connector
c52 cso30:c:OutputProcess connector
p19_propro_p20
PMID: 15691589
Figure 3
c53 cso30:c:InputAssociation connector
c54 cso30:c:InputProcess connector
c55 cso30:c:OutputProcess connector
p19_propro_p21
PMID: 15691589
Figure 3
c56 cso30:c:InputAssociation connector
c57 cso30:c:InputProcess connector
c58 cso30:c:OutputProcess connector
p19_propro_p22
PMID: 15691589
Figure 3
c59 cso30:c:InputAssociation connector
c60 cso30:c:InputProcess connector
c61 cso30:c:OutputProcess connector
p19_propro_p23
PMID: 15691589
Figure 3
c62 cso30:c:InputAssociation connector
c63 cso30:c:InputProcess connector
c64 cso30:c:OutputProcess connector
p19_propro_p24
PMID: 15691589
Figure 3
c65 cso30:c:InputAssociation connector
c66 cso30:c:InputProcess connector
c67 cso30:c:OutputProcess connector
p19_propro_p25
PMID: 15691589
Figure 3
c68 cso30:c:InputAssociation connector
c69 cso30:c:InputProcess connector
c70 cso30:c:OutputProcess connector
p19_propro_p26
PMID: 15691589
Figure 3
c71 cso30:c:InputAssociation connector
c72 cso30:c:InputProcess connector
c73 cso30:c:OutputProcess connector
p19_propro_p27
PMID: 15691589
Figure 3
c74 cso30:c:InputAssociation connector
c75 cso30:c:InputProcess connector
c76 cso30:c:OutputProcess connector
p19_propro_p28
PMID: 15691589
Figure 3
c77 cso30:c:InputAssociation connector
c78 cso30:c:InputProcess connector
c79 cso30:c:OutputProcess connector
p19_propro_p29
PMID: 15691589
Figure 3
c80 cso30:c:InputAssociation connector
c81 cso30:c:InputProcess connector
c82 cso30:c:OutputProcess connector
p19_propro_p30
PMID: 15691589
Figure 3
c83 cso30:c:InputAssociation connector
c84 cso30:c:InputProcess connector
c85 cso30:c:OutputProcess connector
p19_propro_p31
PMID: 15691589
Figure 3
c86 cso30:c:InputAssociation connector
c87 cso30:c:InputProcess connector
c88 cso30:c:OutputProcess connector
p19_propro_p32
PMID: 15691589
Figure 3
c89 cso30:c:InputAssociation connector
c90 cso30:c:InputProcess connector
c91 cso30:c:OutputProcess connector
p19_propro_p33
PMID: 15691589
Figure 3
c92 cso30:c:InputAssociation connector
c93 cso30:c:InputProcess connector
c94 cso30:c:OutputProcess connector
p19_propro_p34
PMID: 15691589
Figure 3
c95 cso30:c:InputAssociation connector
c96 cso30:c:InputProcess connector
c97 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 15691589
Figure 3
c98 cso30:c:InputAssociation connector
c99 cso30:c:OutputProcess connector
p35_propro_p36
PMID: 15691589
Figure 3
c100 cso30:c:InputAssociation connector
c101 cso30:c:OutputProcess connector
p35_propro_p37
PMID: 15691589
Figure 3
c102 cso30:c:InputAssociation connector
c103 cso30:c:OutputProcess connector
p35_propro_p38
PMID: 15691589
Figure 3
c104 cso30:c:InputAssociation connector
c105 cso30:c:OutputProcess connector
p35_propro_p39
PMID: 15691589
Figure 3
c106 cso30:c:InputAssociation connector
c107 cso30:c:OutputProcess connector
p35_propro_p40
PMID: 15691589
Figure 3
c108 cso30:c:InputAssociation connector
c109 cso30:c:OutputProcess connector
p35_propro_p41
PMID: 15691589
Figure 3
c110 cso30:c:InputAssociation connector
c111 cso30:c:OutputProcess connector
p35_propro_p42
PMID: 15691589
Figure 3
c112 cso30:c:InputAssociation connector
c113 cso30:c:OutputProcess connector
p35_propro_p43
PMID: 15691589
Figure 3
c114 cso30:c:InputAssociation connector
c115 cso30:c:OutputProcess connector
p35_propro_p44
PMID: 15691589
Figure 3
c116 cso30:c:InputAssociation connector
c117 cso30:c:OutputProcess connector
p35_propro_p45
PMID: 15691589
Figure 3
c118 cso30:c:InputAssociation connector
c119 cso30:c:OutputProcess connector
p35_propro_p46
PMID: 15691589
Figure 3
c120 cso30:c:InputAssociation connector
c121 cso30:c:OutputProcess connector
NO_enti_e5
NO
TGF-beta_enti_e6
TGF-beta
Fas_enti_e11
Fas
Procaspase_enti_e12
Procaspase
Caspase_enti_e13
Caspase
IAP family_enti_e14
IAP family
iNOS_enti_G010514
iNOS
p53_enti_G010432
p53
LPS_enti_MO000016882
LPS
IFNgamma_enti_MO000016665
IFNgamma
Procaspase{nitrosylated}_enti_e15
Procaspase{nitrosylated}
Caspase{nitrosylated}_enti_e16
Caspase{nitrosylated}
proteosome_enti_e17
proteosome
proteosome{nitrosylated}_enti_e18
proteosome{nitrosylated}
p50:p65_enti_e19
p50:p65
p50{nitrosylated}:p65{nitrosylated}_enti_e20
p50{nitrosylated}:p65{nitrosylated}
15-dPGJ2_enti_e21
15-dPGJ2
IKK_enti_e22
IKK
IKK{active}_enti_e23
IKK{active}
Oxygen superoxide_enti_e24
Oxygen superoxide
Peroxynitrite_enti_e25
Peroxynitrite
PPAR_enti_e26
PPAR
LXRs_enti_e27
LXRs
Fatty acid_enti_e28
Fatty acid
PPAR:Fatty acid_enti_e29
PPAR:Fatty acid
Prostanoids_enti_e30
Prostanoids
PPAR:Prostanoids_enti_e31
PPAR:Prostanoids
Oxysterols_enti_e32
Oxysterols
LXRs:Oxysterols_enti_e33
LXRs:Oxysterols
1400W_enti_e34
1400W
1-NIL_enti_e35
1-NIL
IL-1beta_enti_e36
IL-1beta
TNF-alpha_enti_e37
TNF-alpha
AP-1_enti_e38
AP-1
AP-1{active}_enti_e39
AP-1{active}
NF-KappaB{active}_enti_e40
NF-KappaB{active}
NF-kappaB_enti_e41
NF-kappaB
STAT-1_enti_e42
STAT-1
STAT-1{active}_enti_e43
STAT-1{active}
IRf-1_enti_e44
IRf-1
IRf-1{active}_enti_e45
IRf-1{active}
MMps_enti_e46
MMps
COX-2_enti_e47
COX-2