1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15733829.csml convertedTime:2009.07.01.10:50

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Transcriptional signaling by double-stranded RNA: role of TLR3.
Authors Sen GC, Sarkar SN.
Affiliation Department of Molecular Genetics/NC20, The Lerner Research Institute, TheCleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.seng@ccf.org
Abstract Mammalian Toll-like receptors recognize components of invading microbes andtrigger the first line of innate immune response that is mediated bytranscriptional induction of a large number of cellular genes. Toll-likereceptor 3 (TLR3) is thought to be a major mediator of cellular response toviral infection, because it responds to double-stranded (ds) RNA, a commonby-product of viral replication. This article is focused on the nature of thesignaling pathways activated by TLR3 and dsRNA. The genes induced by TLR3activation include those that encode secreted antiviral cytokines, such asinterferon (IFN), and those that encode intracellular viral stress-inducibleproteins. Recent studies have revealed several unique features of TLR3 signalingthat are highlighted here. Specifically, we discuss the roles of receptortyrosine phosphorylation, PI3 kinase and two-step activation of thetranscription factors, IRF-3 and NF-kappaB, in mediating TLR3-signaling.
PMID 15733829
Model Abstract

Entity

G010228:IFN-beta G010329:TNF-alpha G010657:IL-12 p40 G011345:IL10 MO000000022:p38 MO000000023:JNK MO000000030:PI3K MO000000048:AKT MO000000049:c-Jun MO000000062:ATF-2 MO000000065:RIP1 MO000000077:MAPKs MO000000211:IKK-beta MO000000212:TRAF6 MO000000213:IRAK MO000000214:IL-1 MO000000215:IkappaB:NF-kappaB MO000004670:ERK1 MO000004676:ERK2 MO000007694:IRF-3 MO000007702:IRF-7 MO000008179:PKR MO000013119:STAT1 MO000016573:MyD88 MO000016574:TAK1 MO000016665:IFNgamma MO000016882:LPS MO000016899:FADD MO000017247:IL-10 MO000017265:IL-12 MO000017462:CBP MO000019005:MKK6 MO000019331:TBK1 MO000019394:TLR4 MO000019397:TLR2 MO000019398:TLR3 MO000022125:TAB2 MO000022224:dsRNA MO000036852:AP1 MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000068831:MAL MO000103999:mda5 MO000106519:lauric acid e1: e10: e100:IL-1R e101:IL-1: IL-1R e102:IFN gamma receptor e103:IFNgamma: IFN gamma receptor e104:STAT1 {p} e105:RIP1: TRIF e11: e12:ssRNA e13:CpG DNA e14:CpG DNA: TLR9 e15:IFN-alpha e16:ssRNA: TLR7 e17:ssRNA: TLR8 e18:IFNalpha e19:protein F e2: e20:protein F: TLR4 e21:gB protein e22:MV H protein e23:MV H protein: TLR2 e24:gB protein: TLR2 e25:dsRNA:TLR3 {T759}{T858} e26:PTK e27:dsRNA:TLR3 {T759}{T858}: PI3K e28:dsRNA:TLR3 {T759}{T858}: TRIF e29:dsRNA:TLR3 {T759}{T858}: PI3K {activated} e3: e30:dsRNA:TLR3 {T759}{T858}: TRIF: TRAF6 e31:dsRNA:TLR3 {T759}{T858}: TRIF: TRAF6: TAK1: TAB2: PKR e32:IKK-alpha:IKK-beta:IKK-gamma e33:dsRNA:TLR3 {T759}{T858}: TRIF: TBK1 e34:TRAF6: TAK1: TAB2: PKR e35:IKK-alpha:IKK-beta:IKK-gamma {activated} e36:MAPKs {activated} e37:dsRNA:TLR3 {T759}{T858}: TRIF: TBK1 {activated}: IRF-3 e38:NF-kappaB e39:IRF-3 {p} e4: e40:dsRNA:TLR3 {T759}{T858}: TRIF: TBK1 {activated} e41:dsRNA:TLR3 {T759}{T858}: TRIF: TBK1 {activated}: IRF-3 {p} e42:IRF-3: IRF-3 {p} e43:IRF-3: IRF-3 {p} e44:(IRF-3: IRF-3){p} e45:(IRF-3: IRF-3){p}: CBP e46:ISG56 e47:LY294002 e48:Wortmanin e49:genestein e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:LPS: TLR4 e64:LPS: TLR4: MAL e65:LPS: TLR4: TRAM e66:LPS: TLR4: MAL: MyD88 e67:LPS: TLR4: TRAM: TRIF e68:TRAF6 {activated} e69:IRAK {activated} e7: e70:LPS: TLR4: TRAM: TRIF: TRAF6 e71:LPS: TLR4: TRAM: TRIF: TRAF6: TAK1: TAB2: PKR e72:LPS: TLR4: TRAM: TRIF: TBK1 e73:LPS: TLR4: TRAM: TRIF: TBK1 {activated} e74:LPS: TLR4: TRAM: TRIF: TBK1 {activated}: IRF-3 e75:LPS: TLR4: TRAM: TRIF: TBK1 {activated}: IRF-3 {p} e76:Rig1 e77:JNK {activated} e78:c-Jun {activated} e79:p38 {activated} e8: e80:ATF-2 {activated} e81:NF-kappaB {p}{nucleus}: CBP e82:IkappaB {p} e83:IRF-7: MyD88 e84:NF-kappaB {nucleus} e85:IRAK-4: MyD88 e86:lauric acid: TLR4 e87:lauric acid: TLR4 {activated} e88:ERK1 {activated} e89:ERK2 {activated} e9: e90:MIP-2 e91:dsRNA: Rig1 e92:dsRNA: PKR e93:dsRNA: Rig1: TBK1 e94:dsRNA: PKR: PKR {activated}: TRIF e95:dsRNA: PKR: PKR e96:dsRNA: PKR: PKR {activated} e97:dsRNA:mda5 e98:MKK6 {activated} e99:AP1 {activated}

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90
Model Detail
828.0, 1441.0
31.0, 31.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p27

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
994.0, 1308.0
28.0, 28.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p72 p73

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
701.0, 1469.0
30.0, 30.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
666.0, 1406.0
27.0, 27.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p69

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
542.0, 1026.0
27.0, 27.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
485.0, 957.0
30.0, 30.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m80

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
567.0, 359.0
33.0, 33.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p9 p40 p60 p63 p64 p65 p66 p67 p68 p69 p72 p73 p70 p71 p86 p88

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1061.0, 1089.0
30.0, 30.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86

true true true true

csml-variable:Double

m109

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
530.0, 1074.0
28.0, 28.0

c-Jun

--

MO000000049

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
588.0, 1188.0
32.0, 32.0

ATF-2

--

MO000000062

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m86

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000000062

--

Go back
407.0, 1163.0
26.0, 26.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76 p89

true true true true

csml-variable:Double

m98

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
635.0, 981.0
32.0, 32.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p40

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
1032.0, 1156.0
32.0, 32.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
797.0, 775.0
28.0, 28.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p34 p37

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1041.0, 687.0
28.0, 28.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
1279.0, 1091.0
34.0, 34.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
901.0, 995.0
28.0, 28.0

IkappaB:NF-kappaB

--

MO000000215

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53 p55 p63 p64 p75 p86 p90

true true true true

csml-variable:Double

m186

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
642.0, 368.0
28.5, 28.5

ERK1

--

MO000004670

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65 p67

true true true true

csml-variable:Double

m549

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
649.0, 409.0
30.0, 30.0

ERK2

--

MO000004676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p66 p68

true true true true

csml-variable:Double

m554

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
753.0, 591.0
36.0, 36.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p43 p46 p47 p77

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
983.0, 392.0
34.0, 34.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
874.0, 859.0
27.0, 27.0

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p38 p78

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
365.0, 345.0
29.0, 29.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p88

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
1096.0, 496.0
32.0, 32.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32 p46 p47 p19 p56 p57 p58 p59

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
799.0, 825.0
34.0, 34.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p38

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
215.0, 343.0
26.0, 26.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p87

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
1143.0, 229.0
32.0, 32.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
414.0, 1202.0
28.0, 28.0

FADD

--

MO000016899

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76

true true true true

csml-variable:Double

m1814

10

false

infinite

0

unit false false false
InterProIPR001875
TRANSPATHMO000016899

--

Go back
493.0, 1425.0
30.0, 30.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

p69

--

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
495.0, 1459.0
26.0, 26.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p60

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
840.0, 1330.0
32.0, 32.0

CBP

--

MO000017462

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p52

true true true true

csml-variable:Double

m2282

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000017462

--

Go back
546.0, 1238.0
28.0, 28.0

MKK6

--

MO000019005

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p83

true true true true

csml-variable:Double

m3613

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
814.0, 520.0
32.0, 32.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p41 p76

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1026.0, 296.0
26.0, 26.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p29 p61

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
706.0, 300.0
28.0, 28.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p7

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
368.0, 702.0
30.0, 30.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
870.0, 796.0
26.0, 26.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p38

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
203.0, 643.0
34.0, 34.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p74 p78 p82

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
553.0, 1329.0
27.0, 27.0

AP1

--

MO000036852

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p84

true true true true

csml-variable:Double

m15167

10

false

infinite

0

unit false false false
TRANSPATHMO000036852

--

Go back
930.0, 487.0
27.0, 27.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
669.0, 451.0
30.0, 30.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p33 p79 p89

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1105.0, 407.0
28.0, 28.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
360.0, 646.0
30.0, 30.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p8

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
492.0, 294.0
30.0, 30.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
368.0, 790.0
29.0, 29.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
424.0, 290.0
29.0, 29.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
1094.0, 352.0
26.0, 26.0

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
368.0, 1320.0
32.0, 32.0

mda5

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p82

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
922.0, 180.0
28.0, 28.0

lauric acid

--

MO000106519

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m347589

10

false

infinite

0

unit false false false
TRANSPATHMO000106519

--

Go back
266.75, 271.9969080091176
959.206890627009, 1392.768405190415

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
284.0, 315.0
907.4528182816184, 1276.5309535917868

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1166.0, 1094.0
36.0, 36.0

IL-1R

--

e100

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85

true true true true

csml-variable:Double

m107

10

false

infinite

0

unit false false false
InterProIPR004076
TRANSPATHMO000016595

--

Go back
1176.625, 1152.5
31.09960839860023, 38.08115314114314

IL-1: IL-1R

--

e101

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p85

p86

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
291.375, 376.5
25.32029876977153, 38.95430579964851

IFN gamma receptor

--

e102

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p87

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
292.375, 325.5
23.25, 45.0

IFNgamma: IFN gamma receptor

--

e103

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p87

p88

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
473.5, 346.125
36.04, 27.029999999999998

STAT1 {p}

--

e104

cso30:c:Protein

cso30:i:CC_Cytosol

--

p88

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
469.625, 1138.5
27.849816697217133, 34.101816363939335

RIP1: TRIF

--

e105

cso30:c:Complex

cso30:i:CC_Cytosol

--

p89

p90

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
370.0, 491.1938254982648
266.0745263876508, 444.2091669353152

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
461.5, 194.0
27.89433962264151, 30.430188679245283

ssRNA

--

e12

cso30:c:RnaOther

cso30:i:CC_Extracellular

--

--

p3 p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
208.0, 795.5
53.09576837416481, 18.583518930957677

CpG DNA

--

e13

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
367.5, 842.0
31.371104815864022, 38.41359773371105

CpG DNA: TLR9

--

e14

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p2

p47 p57

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
755.0, 1525.0
34.0, 34.0

IFN-alpha

--

e15

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p19 p56 p57

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
EnsemblENSG00000147877
HGNCIFNA7
OMIM147567
ProteomeHumanPSD/IFNA7
RefSeqNM_021057
TRANSFACG000306
UnigeneHs.282274

--

Go back
332.625, 287.5
28.829653391101484, 35.301616397267125

ssRNA: TLR7

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p46 p19

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
584.625, 286.5
29.401224795867364, 36.00149975004166

ssRNA: TLR8

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p56

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
493.0, 1537.0
30.0, 30.0

IFNalpha

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19 p56 p57

--

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
TRANSPATHMO000097267

--

Go back
1007.5, 196.375
38.88400702987696, 25.27460456942003

protein F

--

e19

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
266.75, 271.9969080091176
959.206890627009, 1392.768405190415

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
977.625, 284.5
28.739835027495424, 35.191634727545406

protein F: TLR4

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
678.5, 190.375
34.24428822495605, 22.258787346221443

gB protein

--

e21

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
777.5, 189.375
37.33743409490333, 24.26933216168717

MV H protein

--

e22

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
764.625, 291.5
29.899308448591896, 36.61139810031661

MV H protein: TLR2

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p7

p64 p67 p68 p72 p71

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
649.625, 292.5
29.050116647225465, 35.57157140476587

gB protein: TLR2

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p6

p63 p65 p66 p73 p70

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
375.625, 534.5
30.029953341109817, 36.77137143809365

dsRNA:TLR3 {T759}{T858}

--

e25

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p8

p9 p10

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
387.5, 424.125
32.68, 24.51

PTK

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
435.875, 485.5
32.25, 45.0

dsRNA:TLR3 {T759}{T858}: PI3K

--

e27

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p9

p11

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
546.875, 514.5
32.25, 45.0

dsRNA:TLR3 {T759}{T858}: TRIF

--

e28

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p10 p15

p12 p21

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
487.875, 473.5
32.25, 45.0

dsRNA:TLR3 {T759}{T858}: PI3K {activated}

--

e29

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p11

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
285.93413781254014, 291.1810458216578
920.8386150019285, 1354.4001295653356

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
594.875, 794.5
32.25, 45.0

dsRNA:TLR3 {T759}{T858}: TRIF: TRAF6

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p13

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
496.875, 885.5
37.4661864562305, 52.27839970636814

dsRNA:TLR3 {T759}{T858}: TRIF: TRAF6: TAK1: TAB2: PKR

--

e31

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p13

p15

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
793.0, 867.0
36.0, 36.0

IKK-alpha:IKK-beta:IKK-gamma

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p36

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
590.875, 574.5
32.25, 45.0

dsRNA:TLR3 {T759}{T858}: TRIF: TBK1

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p14

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
623.875, 893.5
32.25, 45.0

TRAF6: TAK1: TAB2: PKR

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15 p39

p16 p17 p48 p50

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
789.0, 971.0
36.0, 36.0

IKK-alpha:IKK-beta:IKK-gamma {activated}

--

e35

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16 p36

p55

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
635.0, 1025.0
32.0, 32.0

MAPKs {activated}

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p40

--

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
618.875, 690.5
32.25, 45.0

dsRNA:TLR3 {T759}{T858}: TRIF: TBK1 {activated}: IRF-3

--

e37

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p18

p20

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
768.5, 1116.125
31.240000000000002, 23.429999999999996

NF-kappaB

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

p53 p55 p63 p64 p75 p86 p90

p54

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
837.5, 671.125
35.72, 26.789999999999992

IRF-3 {p}

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

p22 p45 p46 p47 p77

p23

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
321.4247927657396, 324.75328699360296
849.8573050955299, 1287.2556472214442

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
618.875, 634.5
32.25, 45.0

dsRNA:TLR3 {T759}{T858}: TRIF: TBK1 {activated}

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14 p22

p18

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
614.875, 742.5
32.25, 45.0

dsRNA:TLR3 {T759}{T858}: TRIF: TBK1 {activated}: IRF-3 {p}

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p22

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
969.5, 962.125
36.2, 27.149999999999995

IRF-3: IRF-3 {p}

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

p23

p24

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
933.5, 1230.125
36.2, 27.149999999999995

IRF-3: IRF-3 {p}

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

p24

p25

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
950.5, 1333.125
35.56, 26.669999999999995

(IRF-3: IRF-3){p}

--

e44

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p25

p26

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
907.875, 1379.5
32.25, 45.0

(IRF-3: IRF-3){p}: CBP

--

e45

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p26

p27 p28

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
837.5, 1502.0
45.0, 24.0

ISG56

--

e46

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p28

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1281.5, 1513.25
45.0, 25.5

LY294002

--

e47

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p28

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1285.5, 1569.25
45.0, 25.5

Wortmanin

--

e48

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p28

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1281.5, 1477.25
45.0, 25.5

genestein

--

e49

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p28

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
370.0, 491.1938254982648
266.0745263876508, 444.2091669353152

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
607.0, 1162.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
657.2936761946803, 1172.00774093139
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
613.069926437289, 1167.6363602631968
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
613.9370587854731, 1168.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
607.0, 1162.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
607.0, 1162.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
613.9370587854731, 1168.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
946.9158804881849, 1335.426469636829
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
870.6082338479803, 1456.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
607.0, 1162.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
370.0, 491.1938254982648
266.0745263876508, 444.2091669353152

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
716.7511016961721, 1349.6637213250547
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
716.2586758712023, 1328.489410851356
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
737.4329863449013, 1387.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1103.625, 285.5
31.099608398600232, 38.08115314114314

LPS: TLR4

--

e63

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p29

p30 p31 p60

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1174.875, 330.5
29.140805652413288, 40.66158928243715

LPS: TLR4: MAL

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p32

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1174.875, 398.5
32.25, 45.0

LPS: TLR4: TRAM

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p31

p33

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1171.5, 811.0
31.15507432556432, 43.47219673334557

LPS: TLR4: MAL: MyD88

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

p35

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1170.875, 470.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p33 p39

p37 p41

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1041.0, 831.0
28.0, 28.0

TRAF6 {activated}

--

e68

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

p36 p40

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
984.0, 696.0
24.0, 24.0

IRAK {activated}

--

e69

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

p34

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
285.0, 275.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1171.875, 871.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF: TRAF6

--

e70

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p37

p38

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1171.875, 939.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF: TRAF6: TAK1: TAB2: PKR

--

e71

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p38

p39

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1174.875, 558.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF: TBK1

--

e72

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41 p45

p42

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1174.875, 614.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF: TBK1 {activated}

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p42

p43

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1174.875, 670.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF: TBK1 {activated}: IRF-3

--

e74

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43

p44

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1174.875, 734.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF: TBK1 {activated}: IRF-3 {p}

--

e75

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p44

p45

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
357.125, 1157.5
22.45577581002214, 36.414771583819686

Rig1

--

e76

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p74

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
489.0, 1013.0
30.0, 30.0

JNK {activated}

--

e77

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

p49

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
534.0, 1138.0
28.0, 28.0

c-Jun {activated}

--

e78

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

p27

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
573.0, 1071.0
27.0, 27.0

p38 {activated}

--

e79

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

p51

true true true true

csml-variable:Double

m85

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
288.0, 296.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
632.0, 1152.0
32.0, 32.0

ATF-2 {activated}

--

e80

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51

p27

true true true true

csml-variable:Double

m87

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000000062

--

Go back
768.625, 1267.5
29.18076153974338, 35.73154474254291

NF-kappaB {p}{nucleus}: CBP

--

e81

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p52

p27

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1045.5, 1006.125
37.0, 27.749999999999993

IkappaB {p}

--

e82

cso30:c:Protein

cso30:i:CC_Cytosol

--

p53 p55 p63 p64 p86 p90

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
917.625, 443.5
28.960298283619398, 35.461589735044164

IRF-7: MyD88

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p58

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
789.5, 1220.125
35.56, 26.67

NF-kappaB {nucleus}

--

e84

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p54

p52

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
881.625, 499.5
28.07027995334111, 34.37177137143809

IRAK-4: MyD88

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p59

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
920.625, 299.5
29.8993084485919, 36.61139810031661

lauric acid: TLR4

--

e86

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p61

p62

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
864.625, 303.5
29.8993084485919, 36.61139810031661

lauric acid: TLR4 {activated}

--

e87

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p62

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
818.0, 360.0
28.5, 28.5

ERK1 {activated}

--

e88

cso30:c:Protein

cso30:i:CC_CellComponent

--

p65 p67

--

true true true true

csml-variable:Double

m94

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
825.0, 407.0
30.0, 30.0

ERK2 {activated}

--

e89

cso30:c:Protein

cso30:i:CC_CellComponent

--

p66 p68

--

true true true true

csml-variable:Double

m95

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
296.0, 317.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
946.0, 1418.0
28.0, 28.0

MIP-2

--

e90

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p70 p71

--

true true true true

csml-variable:Double

m96

10

false

infinite

0

unit false false false
Affymetrix101160_at
EnsemblENSMUSG00000058427
MGDCxcl2
ProteomeHumanPSD/Cxcl2
RefSeqNM_009140
TRANSFACG037261
UnigeneMm.457821

--

Go back
349.625, 1210.5
28.829653391101488, 35.301616397267125

dsRNA: Rig1

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

p74

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
357.625, 969.5
29.54820029995001, 36.18146975504082

dsRNA: PKR

--

e92

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p78

p80

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
408.875, 1258.5
30.96370893741971, 43.205175261515876

dsRNA: Rig1: TBK1

--

e93

cso30:c:Complex

cso30:i:CC_Cytosol

--

p76

p75 p77

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
412.875, 1106.5
30.829555881813178, 43.017984951367225

dsRNA: PKR: PKR {activated}: TRIF

--

e94

cso30:c:Complex

cso30:i:CC_Cytosol

--

p79

p83

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
355.875, 1017.5
32.25, 45.0

dsRNA: PKR: PKR

--

e95

cso30:c:Complex

cso30:i:CC_Cytosol

--

p80

p81

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
355.875, 1085.5
32.25, 45.0

dsRNA: PKR: PKR {activated}

--

e96

cso30:c:Complex

cso30:i:CC_Cytosol

--

p81

p79

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
372.625, 1361.5
29.8993084485919, 36.61139810031661

dsRNA:mda5

--

e97

cso30:c:Complex

cso30:i:CC_Cytosol

--

p82

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
550.0, 1290.0
28.0, 28.0

MKK6 {activated}

--

e98

cso30:c:Protein

cso30:i:CC_CellComponent

--

p83

p84

true true true true

csml-variable:Double

m105

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
554.0, 1368.0
23.0, 23.0

AP1 {activated}

--

e99

cso30:c:Protein

cso30:i:CC_CellComponent

--

p84

--

true true true true

csml-variable:Double

m106

10

false

infinite

0

unit false false false
TRANSPATHMO000036852

--

Go back
290.0, 648.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 15733829 The N-terminal region of the protein recognizes the ligand, dsRNA, in the lumen of endosomes whereas the C-terminal signaling domain resides in the cytoplasm.

Go back
479.0, 541.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 MO000041125

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c32 : 1

m25*m18998*0.1

nodelay

--

true

0

false

PMID: 15733829 Activated TLR3 also activate TBK1 via TRIF, which causes serine phosphorylation of IRF-3 resulting in its dimerization and nuclear translocation. PMID: 15733829 Thus, the recruitment of the two signaling kinases, TBK1 and PI3 kinase, by TLR3 can be mediated by phosphorylated Tyr858 and Tyr759, respectively.

Go back
489.0, 425.0
30.0, 30.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e27

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 15733829 PI3 kinase is recruited by Tyr759 and activated.

Go back
694.0, 776.0
25.0, 25.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e28 MO000000212

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m29*m183*0.1

nodelay

--

true

0

false

PMID: 15733829 TRIF recruits TRAF6 via a specific TRAF6-binding sequence and initiates the NF-kappaB signaling pathway.

Go back
694.0, 836.0
25.0, 25.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 MO000008179 MO000016574 MO000022125

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c40 : 1
stoichiometry:c39 : 1

m31*m1055*m1573*m6433*0.1

nodelay

--

true

0

false

PMID: 15733829, 12609980 Recruitment of TRAF6 by TRIF leads to recruitment of TAB2, TAK1 and PKR followed by release of the whole complex to the cytoplasm and activation of the IKK complex and MAP kinases.

Go back
670.0, 584.0
26.0, 26.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e33

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c62 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 15733829 Activated TLR3 also activate TBK1 via TRIF, which causes serine phosphorylation of IRF-3 resulting in its dimerization and nuclear translocation.

Go back
550.0, 804.0
25.0, 25.0

p15

p15

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e31

e34 e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 15733829, 12609980 Recruitment of TRAF6 by TRIF leads to recruitment of TAB2, TAK1 and PKR followed by release of the whole complex to the cytoplasm and activation of the IKK complex and MAP kinases.

Go back
766.0, 924.0
25.0, 25.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c49 : 1
stoichiometry:c48 : 1

m33*m35*0.1

nodelay

--

true

0

false

PMID: 15733829, 12609980 Recruitment of TRAF6 by TRIF leads to recruitment of TAB2, TAK1 and PKR followed by release of the whole complex to the cytoplasm and activation of the IKK complex and MAP kinases. PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
705.0, 983.0
27.0, 27.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000077 e34

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c52 : 1
stoichiometry:c51 : 1

m69*m35*0.1

nodelay

--

true

0

false

PMID: 15733829, 12609980 Recruitment of TRAF6 by TRIF leads to recruitment of TAB2, TAK1 and PKR followed by release of the whole complex to the cytoplasm and activation of the IKK complex and MAP kinases. PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
691.0, 645.0
23.0, 23.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007694 e40

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c56 : 1
stoichiometry:c60 : 1

m977*m42*0.1

nodelay

--

true

0

false

PMID: 15733829 In vitro biochemical analyses established that TBK1 can directly bind to IRF-3 and phosphorylate its critical residues.

Go back
615.0, 1539.0
25.0, 25.0

p19

p19

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e15 e16 MO000016573

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c166 : 1
stoichiometry:c175 : 1
stoichiometry:c164 : 1

m15*m16*m1572*0.1

nodelay

--

true

0

false

PMID: 15733829, 9697844 IFN-alpha induction by TLR7, TLR8 and TLR9 requires MyD88.

Go back
302.0, 786.0
27.0, 27.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e13 MO000042012 MO000000030

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c53 : 1
stoichiometry:c3 : 1

m13*m19828*m27*0.1

nodelay

--

true

0

false

PMID: 15733829, 11130078 TLR9, on the other hand, recognizes DNA containing unmethylated CpG motifs common to both bacterial and viral genomes. PMID: 15733829, 12119352 Finally, PI3 kinase plays a critical role in shuttling CpG DNA to TLR9.

Go back
693.0, 683.0
27.0, 27.0

p20

p20

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e37

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c63 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 15733829 In vitro biochemical analyses established that TBK1 can directly bind to IRF-3 and phosphorylate its critical residues.

Go back
647.0, 525.0
23.0, 23.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e28 MO000019331

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m29*m3902*0.1

nodelay

--

true

0

false

PMID: 15733829 It is likely that TLR3, TRIF, TBK1 and IRF-3 form a multi-component protein complex from which phosphorylated IRF-3 is released to transmit the signal to the nucleus.

Go back
765.0, 671.0
27.0, 27.0

p22

p22

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e41

e39 e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 15733829 It is likely that TLR3, TRIF, TBK1 and IRF-3 form a multi-component protein complex from which phosphorylated IRF-3 is released to transmit the signal to the nucleus.

Go back
975.0, 755.0
25.0, 25.0

p23

p23

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e39

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 15733829 Activated TLR3 also activate TBK1 via TRIF, which causes serine phosphorylation of IRF-3 resulting in its dimerization and nuclear translocation. PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
975.0, 1123.0
25.0, 25.0

p24

p24

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 15733829 Activated TLR3 also activate TBK1 via TRIF, which causes serine phosphorylation of IRF-3 resulting in its dimerization and nuclear translocation. PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
900.0, 1272.0
23.0, 23.0

p25

p25

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 15733829 A complete activation of IRF-3 requires further phosphorylation by PI3 kinase/Akt mediated pathway so that it can form a stable transcription complex with CBP/co-activator at ISRE cis-element to activate gene transcription. PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
899.0, 1333.0
25.0, 25.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e44 MO000017462

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c74 : 1

m46*m2282*0.1

nodelay

--

true

0

false

PMID: 15733829 A complete activation of IRF-3 requires further phosphorylation by PI3 kinase/Akt mediated pathway so that it can form a stable transcription complex with CBP/co-activator at ISRE cis-element to activate gene transcription. PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
832.0, 1393.0
24.0, 24.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e45 e78 e80 e81

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c247 : 1
stoichiometry:c76 : 1

m47*m83*m87*m88*0.1

nodelay

--

true

0

false

PMID: 15733829 These factors can coordinately induce transcription of some genes, such as the IFN-beta gene, or they can act individually to induce transcription of different sets of genes. PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
915.0, 1501.0
25.0, 25.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e45 e47 e48 e49

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c78 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 15733829 when IRF-3 is fully activated by both the TBK1 pathway and the PI3 kinase pathway, it can bind to the promoter and CBP and drive transcription of the ISG56 gene. PMID: 15733829 Both LY294002 and Wortmannin inhibited, in a dose-dependent fashion, ISG56 induction by dsRNA. PMID: 15733829 This induction is blocked by genestein, an inhibitor of tyrosine kinase activity. PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
1094.0, 236.0
27.0, 27.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000016882

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m3961*m155666*0.1

nodelay

--

true

0

false

PMID: 15733829, 11526399, 14556004, 12721283 LPS activated TLR4 uses two adaptor proteins, TIRAP (also known as MAL) [62] and [63] and TRAM (also known as TICAM2 and TIRP) [64], [65] and [66] to imitate two independent signaling pathways.

Go back
394.0, 240.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e12

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c9 : 1
stoichiometry:c12 : 1

m19940*m12*0.1

nodelay

--

true

0

false

PMID: 15733829, 15123819 mouse TLR7 or human TLR8 recognizes viral single-stranded RNAs.

Go back
1225.0, 255.0
27.0, 27.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 MO000068831

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c90 : 1
stoichiometry:c87 : 1

m65*m43675*0.1

nodelay

--

true

0

false

PMID: 15733829, 11526399, 14556004, 12721283 LPS activated TLR4 uses two adaptor proteins, TIRAP (also known as MAL) [62] and [63] and TRAM (also known as TICAM2 and TIRP) [64], [65] and [66] to imitate two independent signaling pathways.

Go back
1250.0, 312.0
25.0, 25.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 MO000041132

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c91 : 1
stoichiometry:c89 : 1

m65*m19005*0.1

nodelay

--

true

0

false

PMID: 15733829, 11526399, 14556004, 12721283 LPS activated TLR4 uses two adaptor proteins, TIRAP (also known as MAL) [62] and [63] and TRAM (also known as TICAM2 and TIRP) [64], [65] and [66] to imitate two independent signaling pathways.

Go back
1319.0, 512.0
25.0, 25.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e64 MO000016573

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m66*m1572*0.1

nodelay

--

true

0

false

PMID: 15733829 TIRAP recruits MyD88 and triggers the usual IRAK and TRAF6 dependent activation of IKKs and MAPKs.

Go back
1245.0, 431.0
27.0, 27.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041125 e65

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m18998*m67*0.1

nodelay

--

true

0

false

--

Go back
1043.0, 777.0
23.0, 23.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000212 e69

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c103 : 1
stoichiometry:c99 : 1

m183*m72*0.1

nodelay

--

true

0

false

PMID: 15733829 TIRAP recruits MyD88 and triggers the usual IRAK and TRAF6 dependent activation of IKKs and MAPKs.

Go back
1042.0, 748.0
25.0, 25.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000213 e66

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c102 : 1
stoichiometry:c101 : 1

m184*m68*0.1

nodelay

--

true

0

false

PMID: 15733829 TIRAP recruits MyD88 and triggers the usual IRAK and TRAF6 dependent activation of IKKs and MAPKs.

Go back
821.0, 927.0
27.0, 27.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e68

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c106 : 1
stoichiometry:c105 : 1

m33*m71*0.1

nodelay

--

true

0

false

PMID: 15733829 TIRAP recruits MyD88 and triggers the usual IRAK and TRAF6 dependent activation of IKKs and MAPKs.

Go back
1089.0, 811.0
27.0, 27.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e67 MO000000212

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m70*m183*0.1

nodelay

--

true

0

false

PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
1083.0, 889.0
23.0, 23.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022125 MO000016574 MO000008179 e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m6433*m1573*m1055*m73*0.1

nodelay

--

true

0

false

PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
1090.0, 932.0
25.0, 25.0

p39

p39

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e71

e67 e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
519.0, 237.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042007 e12

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m19823*m12*0.1

nodelay

--

true

0

false

PMID: 15733829, 15123819 mouse TLR7 or human TLR8 recognizes viral single-stranded RNAs.

Go back
707.0, 1029.0
23.0, 23.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000077 e68 MO000000030

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c120 : 1
stoichiometry:c184 : 1
stoichiometry:c119 : 1

m69*m71*0.1

nodelay

--

true

0

false

PMID: 15733829 TIRAP recruits MyD88 and triggers the usual IRAK and TRAF6 dependent activation of IKKs and MAPKs.

Go back
1099.0, 569.0
23.0, 23.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e67 MO000019331

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m70*m3902*0.1

nodelay

--

true

0

false

PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
1243.0, 625.0
23.0, 23.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
1099.0, 625.0
23.0, 23.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007694 e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
stoichiometry:c127 : 1

m977*m76*0.1

nodelay

--

true

0

false

PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
1263.0, 781.0
25.0, 25.0

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e74

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
1098.0, 672.0
25.0, 25.0

p45

p45

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e75

e72 e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
817.0, 563.0
27.0, 27.0

p46

p46

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000016573 e16

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c138 : 1
stoichiometry:c141 : 1
stoichiometry:c135 : 1

m977*m1572*m16*0.1

nodelay

--

true

0

false

PMID: 15733829, 12900525 On the other hand, IRF-3 activation by TLR7 and TLR9 is MyD88-dependent [31].

Go back
869.0, 579.0
28.0, 28.0

p47

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000016573 e14

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c137 : 1

m977*m1572*m14*0.1

nodelay

--

true

0

false

PMID: 15733829, 12900525 On the other hand, IRF-3 activation by TLR7 and TLR9 is MyD88-dependent [31].

Go back
536.0, 960.0
23.0, 23.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e34 MO000000023

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m35*m80*0.1

nodelay

--

true

0

false

PMID: 15733829 The TLR3?TRIF pathway causes activation of IRF-3, NF-kappaB, c-Jun and ATF2 via TRAF6 signalosome complex and TBK1.

Go back
483.0, 1075.0
25.0, 25.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000049 e77

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c147 : 1
stoichiometry:c146 : 1

m82*m81*0.1

nodelay

--

true

0

false

PMID: 15733829 The TLR3?TRIF pathway causes activation of IRF-3, NF-kappaB, c-Jun and ATF2 via TRAF6 signalosome complex and TBK1.

Go back
1015.0, 241.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000019394 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m3961*m19*0.1

nodelay

--

true

0

false

PMID: 15733829 For RSV, it is the F protein and for MMTV it is the envelope protein that activates TLR4.

Go back
572.0, 982.0
27.0, 27.0

p50

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e34

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c150 : 1
stoichiometry:c149 : 1

m84*m35*0.1

nodelay

--

true

0

false

PMID: 15733829 The TLR3?TRIF pathway causes activation of IRF-3, NF-kappaB, c-Jun and ATF2 via TRAF6 signalosome complex and TBK1.

Go back
634.0, 1074.0
27.0, 27.0

p51

p51

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000062 e79

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c153 : 1
stoichiometry:c152 : 1

m86*m85*0.1

nodelay

--

true

0

false

PMID: 15733829 The TLR3?TRIF pathway causes activation of IRF-3, NF-kappaB, c-Jun and ATF2 via TRAF6 signalosome complex and TBK1.

Go back
844.0, 1272.0
23.0, 23.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000017462 e84

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c163 : 1
stoichiometry:c156 : 1

m2282*m91*0.1

nodelay

--

true

0

false

PMID: 15733829, 11931769 phosphorylated NF-kappaB p65 isoform can bind to CBP and activate transcription.

Go back
903.0, 1061.0
23.0, 23.0

p53

p53

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000215

e82 e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m186*0.1

nodelay

--

true

0

false

PMID: 15733829 IkappaB phosphorylation releases NF-kappaB, which can now bind DNA and translocate to the nucleus.

Go back
794.0, 1168.0
26.0, 26.0

p54

p54

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e38

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 15733829 IkappaB phosphorylation releases NF-kappaB, which can now bind DNA and translocate to the nucleus.

Go back
770.0, 1036.0
27.0, 27.0

p55

p55

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

e35 MO000000215

e38 e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c273 : 1

m36*m186*0.1

nodelay

--

true

0

false

PMID: 15733829, 15371334 These two proteins kinases are distantly related to the more well-known kinases, IKKalpha and IKKbeta, which are required for NF-kappaB activation. PMID: 15733829 TRAM on the other hand recruits the adaptor protein TRIF and leads to the activation of NF-kappaB, AP-1 and IRF-3 transcription factors using the same pathways used by TRIF bound to activate TLR3.

Go back
571.0, 1507.0
25.0, 25.0

p56

p56

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e15 e17 MO000016573

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c171 : 1
stoichiometry:c174 : 1
stoichiometry:c170 : 1

m15*m17*m1572*0.1

nodelay

--

true

0

false

PMID: 15733829, 9697844 IFN-alpha induction by TLR7, TLR8 and TLR9 requires MyD88.

Go back
546.0, 1482.0
27.0, 27.0

p57

p57

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e15 e14 MO000016573

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c172 : 1
stoichiometry:c173 : 1
stoichiometry:c169 : 1

m15*m14*m1572*0.1

nodelay

--

true

0

false

PMID: 15733829, 9697844 IFN-alpha induction by TLR7, TLR8 and TLR9 requires MyD88.

Go back
988.0, 461.0
23.0, 23.0

p58

p58

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000007702

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c230 : 1
stoichiometry:c177 : 1

m1572*m980*0.1

nodelay

--

true

0

false

PMID: 15733829 The MyD88-dependent pathway is mediated by its interaction with the transcription factor, IRF-7 and the signaling proteins, TRAF6 and IRAK4.

Go back
988.0, 513.0
23.0, 23.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000039077 MO000016573

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m17258*m1572*0.1

nodelay

--

true

0

false

PMID: 15733829 The MyD88-dependent pathway is mediated by its interaction with the transcription factor, IRF-7 and the signaling proteins, TRAF6 and IRAK4.

Go back
708.0, 242.0
23.0, 23.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e21 MO000019397

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m21*m3964*0.1

nodelay

--

true

0

false

PMID: 15733829 HCMV gB protein and MV H protein activate TLR2 and CpG DNA of HSV-1, HSV-2 and MCMV can activate TLR9.

Go back
569.0, 1445.0
30.0, 30.0

p60

p60

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657 MO000000030 e63

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c183 : 1
stoichiometry:c185 : 1
stoichiometry:c182 : 1

m93589*m65*0.1

nodelay

--

true

0

false

PMID: 15733829, 12154357 In dendritic cells, IL-12 production and MAPK activation, in response to LPS stimulation, are down-regulated by PI3 kinase.

Go back
925.0, 231.0
25.0, 25.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000106519 MO000019394

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c187 : 1
stoichiometry:c188 : 1

m347589*m3961*0.1

nodelay

--

true

0

false

PMID: 15733829, 12865424 In contrast, TLR4 activation by lauric acid and the resulting signaling is blocked by inhibitors of PI3 kinase or Akt.

Go back
863.0, 233.0
25.0, 25.0

p62

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c190 : 1

m92*0.1

nodelay

--

true

0

false

PMID: 15733829, 12865424 In contrast, TLR4 activation by lauric acid and the resulting signaling is blocked by inhibitors of PI3 kinase or Akt.

Go back
827.0, 1047.0
25.0, 25.0

p63

p63

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000215 e24 MO000000030

e38 e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c195 : 1
stoichiometry:c197 : 1
stoichiometry:c193 : 1
stoichiometry:c274 : 1

m186*m24*m27*0.1

nodelay

--

true

0

false

PMID: 15733829, 11101877 For TLR2 signaling, both receptor tyrosine phosphorylation and PI3 kinase are required for NF-kappaB activation.

Go back
871.0, 1051.0
25.0, 25.0

p64

p64

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000215 e23 MO000000030

e38 e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c196 : 1
stoichiometry:c198 : 1
stoichiometry:c194 : 1
stoichiometry:c275 : 1

m186*m23*m27*0.1

nodelay

--

true

0

false

PMID: 15733829, 11101877 For TLR2 signaling, both receptor tyrosine phosphorylation and PI3 kinase are required for NF-kappaB activation.

Go back
708.0, 350.0
23.0, 23.0

p65

p65

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e24 MO000004670 MO000000030

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c203 : 1
stoichiometry:c211 : 1
stoichiometry:c207 : 1

m24*m549*m27*0.1

nodelay

--

true

0

false

PMID: 15733829 TLR2 mediated activation of ERK-1/2, but not p38 and JNK1/2, requires PI3 kinase.

Go back
724.0, 438.0
23.0, 23.0

p66

p66

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e24 MO000004676 MO000000030

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c205 : 1
stoichiometry:c214 : 1
stoichiometry:c210 : 1

m24*m554*m27*0.1

nodelay

--

true

0

false

PMID: 15733829 TLR2 mediated activation of ERK-1/2, but not p38 and JNK1/2, requires PI3 kinase.

Go back
743.0, 365.0
25.0, 25.0

p67

p67

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e23 MO000004670 MO000000030

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c204 : 1
stoichiometry:c212 : 1
stoichiometry:c208 : 1

m23*m549*m27*0.1

nodelay

--

true

0

false

PMID: 15733829 TLR2 mediated activation of ERK-1/2, but not p38 and JNK1/2, requires PI3 kinase.

Go back
755.0, 421.0
25.0, 25.0

p68

p68

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e23 MO000004676 MO000000030

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c206 : 1
stoichiometry:c213 : 1
stoichiometry:c209 : 1

m23*m554*m27*0.1

nodelay

--

true

0

false

PMID: 15733829 TLR2 mediated activation of ERK-1/2, but not p38 and JNK1/2, requires PI3 kinase.

Go back
566.0, 1398.0
27.0, 27.0

p69

p69

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011345 MO000000030

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c217 : 1
stoichiometry:c216 : 1

m94230*m27*0.1

nodelay

--

true

0

false

PMID: 15733829, 12847238 Consequently, IL-10 production is suppressed but IL-12 production is enhanced in the absence of PI3 kinase action.

Go back
744.0, 238.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m3964*m22*0.1

nodelay

--

true

0

false

PMID: 15733829 HCMV gB protein and MV H protein activate TLR2 and CpG DNA of HSV-1, HSV-2 and MCMV can activate TLR9.

Go back
1003.0, 1411.0
25.0, 25.0

p70

p70

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e24 MO000000030

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c228 : 1
stoichiometry:c222 : 1

m24*m27*0.1

nodelay

--

true

0

false

PMID: 15733829 In neutrophils, PI3 kinase is required for TLR2-mediated TNF-alpha and MIP-2 gene induction.

Go back
989.0, 1459.0
21.0, 21.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23 MO000000030

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c229 : 1
stoichiometry:c223 : 1

m23*m27*0.1

nodelay

--

true

0

false

PMID: 15733829 In neutrophils, PI3 kinase is required for TLR2-mediated TNF-alpha and MIP-2 gene induction.

Go back
996.0, 1262.0
23.0, 23.0

p72

p72

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23 MO000000030

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c226 : 1
stoichiometry:c221 : 1

m23*m27*0.1

nodelay

--

true

0

false

PMID: 15733829 In neutrophils, PI3 kinase is required for TLR2-mediated TNF-alpha and MIP-2 gene induction.

Go back
996.0, 1358.0
23.0, 23.0

p73

p73

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e24 MO000000030

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c227 : 1
stoichiometry:c220 : 1

m24*m27*0.1

nodelay

--

true

0

false

PMID: 15733829 In neutrophils, PI3 kinase is required for TLR2-mediated TNF-alpha and MIP-2 gene induction.

Go back
180.0, 1216.0
23.0, 23.0

p74

p74

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e76 MO000022224

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c233 : 1
stoichiometry:c232 : 1

m79*m119368*0.1

nodelay

--

true

0

false

PMID: 15733829 This cytoplasmic protein has a helicase domain in the carboxyl terminus, which recognizes dsRNA.

Go back
696.0, 1072.0
23.0, 23.0

p75

p75

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000215 e93

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c240 : 1
stoichiometry:c238 : 1

m186*m100*0.1

nodelay

--

true

0

false

PMID: 1573329 In its N-terminus is a caspase recruitment domain (CARD), which transmits downstream signals that results in the activation of NF-kappaB and IRF-3.

Go back
351.0, 1267.0
25.0, 25.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016899 MO000019331 MO000000065

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c237 : 1
stoichiometry:c239 : 1
stoichiometry:c235 : 1
stoichiometry:c234 : 1

m1814*m3902*m98*0.1

nodelay

--

true

0

false

PMID: 15733829 It remains possible that FADD and RIP1 connect RIG-I and TBK1.

Go back
891.0, 631.0
25.0, 25.0

p77

p77

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e93

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c243 : 1
stoichiometry:c242 : 1

m977*m100*0.1

nodelay

--

true

0

false

PMID: 1573329 In its N-terminus is a caspase recruitment domain (CARD), which transmits downstream signals that results in the activation of NF-kappaB and IRF-3.

Go back
290.0, 950.0
27.0, 27.0

p78

p78

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000008179 MO000022224

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c245 : 1
stoichiometry:c246 : 1

m1055*m119368*0.1

nodelay

--

true

0

false

PMID: 15733829 PKR is the prototypic member of a family of dsRNA-binding protein and this cytoplasmic Ser/Thr protein kinase has been shown to mediate dsRNA-signaling in certain cell types.

Go back
415.0, 1031.0
25.0, 25.0

p79

p79

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e96

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c254 : 1
stoichiometry:c250 : 1

m18998*m103*0.1

nodelay

--

true

0

false

PMID: 15733829 The PKR protein has TRAF-interacting motifs through which several members of this family of adaptor proteins have been shown to interact with dimerized activated PKR.

Go back
338.0, 482.0
27.0, 27.0

p8

p8

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000041446 e26

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c24 : 1
stoichiometry:c23 : 1

m19314*m26*0.1

nodelay

--

true

0

false

PMID: 15733829 Upon activation by dsRNA, TLR3 is tyrosine-phosphorylated at Tyr759 and Tyr858 at the cytoplasmic domain by an unknown protein tyrosine kinase (PTK).

Go back
414.0, 970.0
27.0, 27.0

p80

p80

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e92

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c248 : 1
stoichiometry:c251 : 1

m99*0.1

nodelay

--

true

0

false

PMID: 15733829 The PKR protein has TRAF-interacting motifs through which several members of this family of adaptor proteins have been shown to interact with dimerized activated PKR.

Go back
294.0, 1026.0
27.0, 27.0

p81

p81

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e95

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c253 : 1

m102*0.1

nodelay

--

true

0

false

PMID: 15733829 The PKR protein has TRAF-interacting motifs through which several members of this family of adaptor proteins have been shown to interact with dimerized activated PKR.

Go back
209.0, 1325.0
21.0, 21.0

p82

p82

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000103999

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c256 : 1
stoichiometry:c257 : 1

m119368*m76904*0.1

nodelay

--

true

0

false

PMID: 15733829, 15563593 Like RIG-I, another interferon-inducible helicase, the CARD-containing helicase mda5, can also mediate dsRNA signaling.

Go back
489.0, 1241.0
25.0, 25.0

p83

p83

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019005 e94

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c260 : 1
stoichiometry:c259 : 1

m3613*m101*0.1

nodelay

--

true

0

false

PMID: 15733829 Finally, there is evidence of still another pathway, where dsRNA activated protein kinase PKR can cause activation of MAP kinase kinase 6 (MKK6) to activate AP-1 transcription factors.

Go back
484.0, 1332.0
28.0, 28.0

p84

p84

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000036852 e98

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c261 : 1
stoichiometry:c263 : 1
stoichiometry:c262 : 1

m15167*m105*0.1

nodelay

--

true

0

false

PMID: 15733829 Finally, there is evidence of still another pathway, where dsRNA activated protein kinase PKR can cause activation of MAP kinase kinase 6 (MKK6) to activate AP-1 transcription factors.

Go back
1248.0, 1160.0
23.0, 23.0

p85

p85

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e100 MO000000214

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c264 : 1
stoichiometry:c265 : 1
stoichiometry:c266 : 1

m107*m185*0.1

nodelay

--

true

0

false

PMID: 15733829, 11733537 IL-1 activated phosphorylation of p65 has been shown to require PI3 kinase, Akt and IKKbeta.

Go back
947.0, 1075.0
25.0, 25.0

p86

p86

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000215 e101 MO000000048 MO000000211 MO000000030

e38 e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c267 : 1
stoichiometry:c269 : 1
stoichiometry:c270 : 1
stoichiometry:c271 : 1
stoichiometry:c272 : 1
stoichiometry:c268 : 1
stoichiometry:c276 : 1

m186*m108*m109*m182*m27*0.1

nodelay

--

true

0

false

PMID: 15733829, 11733537 IL-1 activated phosphorylation of p65 has been shown to require PI3 kinase, Akt and IKKbeta.

Go back
221.0, 385.0
21.0, 21.0

p87

p87

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000016665 e102

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c277 : 1
stoichiometry:c278 : 1
stoichiometry:c279 : 1

m1639*m110*0.1

nodelay

--

true

0

false

PMID: 15733829, 33361?33368 PI3 kinase activity is required for the phosphorylation of Ser727 of STAT1 when the activator is IFN-gamma, but not IL-1 and TNF-alpha.

Go back
415.0, 375.0
25.0, 25.0

p88

p88

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 MO000000030 e103

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c280 : 1
stoichiometry:c282 : 1
stoichiometry:c283 : 1
stoichiometry:c281 : 1

m1357*m27*m111*0.1

nodelay

--

true

0

false

PMID: 15733829, 11438544 PI3 kinase activity is required for the phosphorylation of Ser727 of STAT1 when the activator is IFN-gamma, but not IL-1 and TNF-alpha.

Go back
437.0, 1065.0
25.0, 25.0

p89

p89

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000000065

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c284 : 1
stoichiometry:c285 : 1
stoichiometry:c286 : 1

m18998*m98*0.1

nodelay

--

true

0

false

PMID: 15733829, 15064760 The kinase receptor-interacting protein, RIP1, is also recruited by TRIF by its carboxyl terminal region and RIP1 is required for NF-kappaB activation, but not IRF-3 or JNK activation.

Go back
435.0, 431.0
25.0, 25.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 MO000000030

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m25*m27*0.1

nodelay

--

true

0

false

PMID: 15733829 PI3 kinase is recruited by Tyr759 and activated. PMID: 15733829 Thus, the recruitment of the two signaling kinases, TBK1 and PI3 kinase, by TLR3 can be mediated by phosphorylated Tyr858 and Tyr759, respectively.

Go back
735.0, 1047.0
25.0, 25.0

p90

p90

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e105 MO000000215

e38 e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c287 : 1
stoichiometry:c288 : 1
stoichiometry:c289 : 1
stoichiometry:c290 : 1

m113*m186*0.1

nodelay

--

true

0

false

PMID: 15733829, 15064760 The kinase receptor-interacting protein, RIP1, is also recruited by TRIF by its carboxyl terminal region and RIP1 is required for NF-kappaB activation, but not IRF-3 or JNK activation.

Go back
261.0, 801.3897804297072

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.0, 219.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1055.0, 715.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1013.9987028429207, 724.2929730966948

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1074.0308274533256, 770.8167349032339

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1005.0, 720.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
819.0, 903.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
821.0561610125071, 954.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
855.3353514337631, 851.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1108.9464734882456, 516.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.0, 791.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1116.0, 836.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
542.0, 258.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
896.0, 815.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.0, 846.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 875.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1113.9771415042237, 895.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1106.0, 908.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1122.828398279894, 948.6480838483988

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1105.0, 523.8629774954745

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
663.9845634713266, 917.4967355154973

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
667.0, 1007.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
675.0, 1041.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
367.1000730829823, 264.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.9045878653291, 853.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1126.275502546465, 512.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
846.0, 539.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1122.0, 581.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1207.0, 595.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1215.0, 637.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
789.0, 610.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1122.0, 645.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1130.0, 637.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1207.0, 712.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1030.7095750304434, 271.8152001391701

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1214.3531602401445, 767.1513543886333

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1128.9349894126537, 701.3643173537448

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1121.0, 608.3342580445078

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
881.0, 685.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
789.0, 587.7777713001234

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
834.0, 590.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
789.0, 596.0897467238299

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
861.3861999450876, 607.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
851.7961710822492, 516.0

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
904.5467189790695, 518.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1027.0, 222.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
399.0, 603.7802687630364

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
361.0, 313.0

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
565.8599434057004, 926.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
515.0, 972.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.8674523492571, 983.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
516.0, 1088.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.0, 1100.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
498.9922778767137, 1043.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
565.0, 1015.5357429061181

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.0, 1009.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1009.6499055497528, 264.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.4731333462222, 939.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
610.0, 1108.4799802105422

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
648.0, 1101.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.0, 1086.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
562.0, 1164.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
661.0, 1184.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
805.9981103105913, 1284.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
915.0, 1023.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.0, 1303.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
926.0, 1029.6428033978248

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
701.0, 213.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
807.3824930779239, 1078.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
789.0, 1140.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
807.0, 1194.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
820.0, 1247.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.0, 1552.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
647.9807126970203, 1543.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
87.5944437243287, 305.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
603.9434865291524, 1521.9492216607164

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.8224193126193, 1500.676232709847

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
527.4436087949382, 1509.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 273.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
530.3846153846154, 1526.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
111.95865853896908, 306.0

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
243.64108310246797, 867.0

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
579.8654952404764, 517.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
602.2489477531409, 515.0

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
631.5549836390646, 514.0

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1018.5714629908931, 479.5832050204224

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
954.8858914040833, 465.3463717031362

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
957.0, 507.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.945204834583, 514.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
684.6568542494924, 265.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
917.9764358840126, 518.613571991078

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
606.8782684705435, 1464.3902826712724

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
528.8911513906571, 1462.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
140.2512184708571, 378.0

c183

c183

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
587.0, 392.0

c184

c184

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
606.998263987138, 305.0

c185

c185

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
937.0, 208.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
956.7236729481482, 256.33499966393765

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
937.1817712428264, 256.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
891.1214751973158, 264.145770236779

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.0, 267.96782774194344

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.0, 258.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
858.6354954168422, 1019.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.9691115068547, 1023.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
799.0659023220582, 1072.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
806.7140230377476, 1072.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
668.0, 328.0

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
782.0, 328.0

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
590.0, 392.0

c197

c197

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
591.0, 392.0

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
679.0, 324.0

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
336.97643588401263, 801.613571991078

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
771.1214751973158, 214.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.0, 328.0

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
763.6518879601005, 328.0

c201

c201

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
769.7705935588815, 328.0

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
671.0, 368.4680375842995

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
671.0, 378.3330443576975

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
679.0, 429.0

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
679.0, 425.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
731.0, 363.0

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
768.0, 375.319744306791

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
780.0, 426.22965605025496

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
760.0, 261.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
747.0, 428.079787787583

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.0, 363.81062105283695

c211

c211

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
600.0, 376.0

c212

c212

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
600.0, 381.0

c213

c213

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
600.0, 384.0

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
600.9731141883335, 1413.6553244538356

c215

c215

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
530.4396857613915, 1417.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
163.62519116455837, 380.0

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
660.383080943461, 161.59752506516406

c218

c218

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
790.0, 181.55374108718235

c219

c219

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
355.0989706727055, 516.924156955824

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1008.0, 1344.0

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1008.0, 1285.0

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
981.9249690339478, 1426.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
979.848442145943, 1450.45854600288

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
666.0, 123.6929638094806

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
795.0, 75.57037229685261

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
592.0, 392.0

c226

c226

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
591.0, 392.0

c227

c227

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
591.0, 392.0

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
590.0, 392.0

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
361.0, 509.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1000.0, 426.0

c230

c230

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
210.66534474534808, 1179.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
203.0, 1228.0

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
191.73891582232773, 662.0

c233

c233

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
376.0, 1280.0

c234

c234

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
374.79279858428015, 1189.0

c235

c235

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
726.5207574722393, 1014.0

c236

c236

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
381.65685424949237, 1230.0

c237

c237

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
719.0, 1090.0

c238

c238

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
175.5024269124895, 538.0

c239

c239

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
369.28091686182944, 449.0

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
440.0, 1096.5496691065953

c240

c240

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
789.0, 614.0

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
878.1192895849364, 655.0

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
440.0, 662.3859935687975

c243

c243

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
324.90416389685566, 875.0

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
221.0, 677.0

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
317.0, 969.0

c246

c246

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
792.0, 1303.0

c247

c247

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
387.0, 985.5909734841225

c248

c248

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
437.23305191402994, 481.0

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
401.0, 463.1006753912829

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
428.0, 1056.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.65685424949237, 997.0

c251

c251

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
329.0, 1040.0

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
320.0, 1053.0

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
388.0, 1062.009319187599

c254

c254

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
220.0, 677.0

c255

c255

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
238.0, 1336.0

c256

c256

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
230.0, 1339.0

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
521.9960966086966, 1252.0

c258

c258

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
514.0, 1264.0

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
467.1687669068531, 385.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
441.0, 1150.0

c260

c260

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
519.9976215251444, 1344.0

c261

c261

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.0, 1353.0

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
518.7639112242477, 1313.0

c263

c263

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1202.0, 1126.0

c264

c264

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1270.9691115068547, 1125.0

c265

c265

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1216.0, 1172.0

c266

c266

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
923.0, 1023.0

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
807.8057300167486, 1091.0

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
979.5247568634044, 1094.7162536970338

c269

c269

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
449.0, 456.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
979.9282586084793, 1091.0689786887838

c270

c270

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
977.7999954687554, 1105.5099956953175

c271

c271

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
592.0, 392.0

c272

c272

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
797.0, 1022.8624146143251

c273

c273

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.0, 1024.420368542865

c274

c274

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
896.0, 1026.8669836198026

c275

c275

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
972.0, 1036.3535288407923

c276

c276

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
229.0, 369.0

c277

c277

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.0, 396.0

c278

c278

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
242.0, 360.4067376666459

c279

c279

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
406.0, 553.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
394.0, 368.0

c280

c280

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
440.0, 371.22912165261033

c281

c281

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
447.975314678252, 377.0

c282

c282

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
316.0, 352.0

c283

c283

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
457.85381559840204, 481.0

c284

c284

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.0, 1097.659716318877

c285

c285

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
455.0, 1090.0

c286

c286

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.0, 1067.7187093237892

c287

c287

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
767.6520753255473, 1013.0

c288

c288

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
754.0, 1072.0

c289

c289

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.29782299355, 473.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
760.0, 1022.9991090239637

c290

c290

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
329.0, 812.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
468.0, 461.3041949897965

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
504.0, 455.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
502.0, 542.7354436625493

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
576.0, 560.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
727.0, 789.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.6965114603821, 793.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.0, 822.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.9342229330722, 852.0237707010416

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.9844206278631, 843.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
541.5941994015147, 853.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
237.0, 660.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.8046012267691, 812.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
579.0, 537.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.9998071057422, 536.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
628.2394443073428, 548.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
529.0, 836.1804346114993

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
572.0, 829.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
563.0, 568.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
791.2108369169304, 903.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
786.0, 949.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
656.0, 918.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
321.55966466935905, 673.5793885427601

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.0, 997.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.6833366579515, 1006.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
656.0, 933.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
211.52602105698236, 379.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
720.5775375331502, 622.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.0, 597.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
651.0, 657.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.6253297034907, 1013.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.0, 1063.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
791.8372338729644, 1007.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
315.0, 661.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
657.1709862283207, 667.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.0, 701.676232709847

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.0533836092978, 610.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.9721061734058, 710.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
647.0, 696.7678096620695

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.0, 685.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
658.8550669730649, 661.515890117609

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
873.0, 696.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
988.0, 780.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 989.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
418.31242957138693, 271.7381712052921

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
959.5020050995781, 1148.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
928.6568542494924, 1257.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
922.0, 1295.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.0, 1346.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
914.0, 1358.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.0, 1346.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.0, 1417.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
863.9940893970505, 1403.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
891.0, 1514.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
925.0, 1425.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
513.0, 267.3974247877977

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
943.9979325912348, 1514.1285884751567

c80

c80

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
943.9372876111099, 1516.7055255256903

c81

c81

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
943.9917495458793, 1491.0

c82

c82

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1052.0, 267.20633098764773

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1128.9671456517417, 247.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1110.0, 263.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1135.0, 275.2987830845308

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1205.1772308771083, 282.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1135.0, 307.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1211.7836995264074, 337.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
425.77511991082457, 218.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1120.0, 283.73090930902015

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1133.0, 338.4376015698018

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1204.0, 369.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1128.0, 513.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1200.4076483908457, 537.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.0, 446.27821987584076

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1207.0, 427.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1209.6564023547028, 454.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
825.0, 789.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1055.0, 800.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back