1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15809659.csml convertedTime:2009.07.01.10:51

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title A pervasive role of ubiquitin conjugation in activation and termination ofIkappaB kinase pathways.
Authors Krappmann D, Scheidereit C.
Affiliation Max-Delbruck-Center for Molecular Medicine, Robert-Rossle-Strasse 10, D-13122Berlin, Germany.
Abstract The nuclear factor (NF)-kappaB pathway is a paradigm for gene expression controlby ubiquitin-mediated protein degradation. In stimulated cells, phosphorylationby the IkappaB kinase (IKK) complex primes NF-kappaB-inhibiting IkappaBmolecules for lysine (Lys)-48-linked polyubiquitination and subsequentdestruction by the 26S proteasome. However, recent studies indicate that theubiquitin (Ub) system controls NF-kappaB pathways at many levels. Ub ligases areactivated by different upstream signalling pathways, and they function ascentral regulators of IKK and c-Jun amino-terminal kinase activation. Theassembly of Lys 63 polyUb chains provides docking surfaces for the recruitmentof IKK-activating complexes, a reaction that is counteracted by deubiquitinatingenzymes. Furthermore, Ub conjugation targets upstream signalling mediators aswell as nuclear NF-kappaB for post-inductive degradation to limit the durationof signalling.
PMID 15809659
Model Abstract

Entity

G010405:A20 G013179:CYLD MO000000023:JNK MO000000102:PLCgamma MO000000134:PKCdelta MO000000208:RIP MO000000209:TRAF2 MO000000212:TRAF6 MO000000248:IKKalpha:IKK-beta:IKK-gamma MO000000289:TNF-alpha MO000016591:A20 MO000016632:p50:RelA-p65{active} MO000016882:LPS MO000016963:TRAF6{ub} oligomer MO000017004:SOCS-1 MO000017913:Nedd4 MO000017949:RIP2 MO000020461:Nod2 MO000022136:Ubc13 MO000022281:p62 MO000038234:Itch MO000038724:p50:RelA-p65:IkappaB MO000041169:CYLD MO000063418:MALT1 e1: e10:protein remnants e11:RIP{ub} e12:JNK{active} e13:TAK1:TAB2:TAB3 e14:TRAF2{ub}:TAK1:TAB2:TAB3 e15:RIP{ub}:TAK1:TAB2:TAB3 e16:IKKalpha:IKKbeta{p}:IKK-gamma e17:IL-1:IL-1R e18:Ligand:TLR e19:TRAF6{ub} e2: e20:TIFA e21:IKKalpha:IKk-beta:IKK-gamma{ub} e22:TRAF6{ub} oligomer:TAK1:TAB2:TAB3 e23:IKKalpha:IKk-beta{p}:IKK-gamma{ub} e24:p50:RelA-p65:IkappaB{p} e25:BetaTRCP e26:p50:RelA-p65:IkappaB{p}{ub} e27:PLIC e28:Cezanne e29:Ligand:TCR e3: e30:PLCgamma{active} e31:PKCdelta{active} e32:BCL10 e33:CARMA1 e34:BCL10:MALT1:CARMA1 e35:BCL10:MALT1 oligomer:CARMA1 e36:Bacteria e37:Nod2:Bacteria e38:TRABID e39:TRAF6:Cezanna e4: e40:TRAF6:TRABID e41:TNFR1 e42:NF-KappaB e43:TNFRII e44:c-IAP1 e45:c-IAP1 e46:PLCgamma{ub} e47:PKCdelta{ub} e48:Ligand:CD28 e49:BCL10{ub} e5:TNF-alpha:TNFR e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TRAF2{ub} e60: e61: e62: e63:p62:IKK-alpha:IKK-beta:IKK-gamma{uba] e64:p62:RIP{ub} e65:TRAF2{ub}:p62 e66:TRAF6{ub}:p62 e67:RelA-p65:DNA e68:RelA-p65{ub}:DNA e69:protein degradants e7: e70:SOCS-1:p50:RelA-p65{active} e71:SOCS-1:p50:RelA-p65{ub} e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p7 p8 p9
Model Detail
479.0, 1375.0
26.0, 26.0

A20

--

G010405

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p45

--

true true true true

csml-variable:Double

m93378

10

false

infinite

0

unit false false false
TRANSFACG010405

--

Go back
362.0, 1254.0
28.0, 28.0

CYLD

--

G013179

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p28

--

true true true true

csml-variable:Double

m95668

10

false

infinite

0

unit false false false
TRANSFACG013179

--

Go back
631.0, 491.0
18.0, 18.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p12

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
762.0, 322.0
20.0, 20.0

PLCgamma

--

MO000000102

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m90

10

false

infinite

0

unit false false false
TRANSPATHMO000000102

--

Go back
926.0, 474.0
20.0, 20.0

PKCdelta

--

MO000000134

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m121

10

false

infinite

0

unit false false false
TRANSPATHMO000000134

--

Go back
282.0, 634.0
19.0, 19.0

RIP

--

MO000000208

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

p2 p36 p42

true true true true

csml-variable:Double

m179

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000208

--

Go back
395.0, 551.0
17.0, 17.0

TRAF2

--

MO000000209

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

p1 p2 p43

true true true true

csml-variable:Double

m180

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000209

--

Go back
531.0, 307.0
18.0, 18.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30 p35

p8 p9 p38 p39

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
528.0, 744.0
40.0, 40.0

IKKalpha:IKK-beta:IKK-gamma

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

p11 p7 p6 p22 p24 p26

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
309.0, 125.0
22.0, 22.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
302.0, 330.0
20.0, 20.0

A20

--

MO000016591

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34 p35 p36

true true true true

csml-variable:Double

m1585

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
746.0, 1278.0
20.0, 20.0

p50:RelA-p65{active}

--

MO000016632

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27 p18 p32 p33

p28 p45 p46 p61

true true true true

csml-variable:Double

m1617

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
1253.0, 1225.0
22.0, 22.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
769.0, 485.0
21.0, 21.0

TRAF6{ub} oligomer

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10

p11 p13

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
903.0, 1287.0
18.0, 18.0

SOCS-1

--

MO000017004

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m1906

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017004

--

Go back
1079.0, 703.0
18.0, 18.0

Nedd4

--

MO000017913

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52 p51

true true true true

csml-variable:Double

m2654

10

false

infinite

0

unit false false false
TRANSPATHMO000017913

--

Go back
1064.0, 972.0
24.0, 24.0

RIP2

--

MO000017949

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m2684

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017949

--

Go back
999.0, 779.0
18.0, 18.0

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
431.0, 423.0
18.0, 18.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p8 p9

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
1050.0, 1082.0
20.0, 20.0

p62

--

MO000022281

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55 p56 p57 p58

true true true true

csml-variable:Double

m6578

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000022281

--

Go back
1015.0, 479.0
18.0, 18.0

Itch

--

MO000038234

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47 p49

true true true true

csml-variable:Double

m16459

10

false

infinite

0

unit false false false
TRANSPATHMO000038234

--

Go back
588.0, 908.0
24.0, 24.0

p50:RelA-p65:IkappaB

--

MO000038724

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p16 p27 p32 p33

true true true true

csml-variable:Double

m16910

10

false

infinite

0

unit false false false
TRANSPATHMO000038724

--

Go back
498.0, 1002.0
19.0, 19.0

CYLD

--

MO000041169

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p30 p31 p32 p33

true true true true

csml-variable:Double

m19042

10

false

infinite

0

unit false false false
TRANSPATHMO000041169

--

Go back
1089.0, 557.0
22.0, 22.0

MALT1

--

MO000063418

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m38297

10

false

infinite

0

unit false false false
TRANSPATHMO000063418

--

Go back
197.40562838427488, 187.00626732807694
1037.8635873339126, 1506.9779288088398

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
367.0, 844.0
17.54164273406088, 16.956921309592182

protein remnants

--

e10

cso30:c:EntityBiological

cso30:i:CC_Cytoplasm

--

p29 p30 p31 p18 p37 p44 p53 p48 p54 p63

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
358.0, 634.0
19.0, 19.0

RIP{ub}

--

e11

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2 p36 p42

p5 p34 p37 p56

true true true true

csml-variable:Double

m11

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000208

--

Go back
531.0, 563.0
18.0, 18.0

JNK{active}

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3 p12

--

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
648.5, 604.0
22.892824371444302, 31.94347586713159

TAK1:TAB2:TAB3

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p4 p5 p13

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
542.0, 671.0
20.735294117647058, 34.55882352941177

TRAF2{ub}:TAK1:TAB2:TAB3

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p7

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
350.0, 775.0
20.735294117647058, 34.55882352941177

RIP{ub}:TAK1:TAB2:TAB3

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p6

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
648.0, 844.0
40.0, 40.0

IKKalpha:IKKbeta{p}:IKK-gamma

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7 p6

p14

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
590.5, 206.0
18.90857268142951, 36.59723744792808

IL-1:IL-1R

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p8 p33

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
710.5, 205.0
19.234816926112693, 37.22867792150845

Ligand:TLR

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
643.0, 395.0
18.0, 18.0

TRAF6{ub}

--

e19

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8 p9

p10 p12 p30 p35 p58

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
197.40562838427488, 187.00626732807694
1037.8635873339126, 1506.9779288088398

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
721.0, 356.0
13.681010289990645, 31.57156220767071

TIFA

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
800.0, 588.0
40.0, 40.0

IKKalpha:IKk-beta:IKK-gamma{ub}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11 p22 p26

p15 p27 p31 p55

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
810.0, 655.0
20.558823529411768, 34.26470588235294

TRAF6{ub} oligomer:TAK1:TAB2:TAB3

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p15

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
808.0, 900.0
40.0, 40.0

IKKalpha:IKk-beta{p}:IKK-gamma{ub}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15 p24

p16

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
644.0, 1036.0
24.0, 24.0

p50:RelA-p65:IkappaB{p}

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14 p16

p17

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000038724

--

Go back
772.0, 963.5
23.200000000000003, 17.400000000000002

BetaTRCP

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
744.0, 1128.0
24.0, 24.0

p50:RelA-p65:IkappaB{p}{ub}

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

p18

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000038724

--

Go back
812.5, 1120.0
15.018917287180521, 24.355001006238684

PLIC

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p18

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
925.0, 286.5
30.11471120949889, 18.570738579190987

Cezanne

--

e28

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p38 p40

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
838.5, 210.0
18.12014909011182, 35.07125630344223

Ligand:TCR

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p19 p50

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
218.16290013095312, 207.76353907475524
996.3490438405568, 1465.463385315484

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
838.0, 390.0
20.0, 20.0

PLCgamma{active}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19

p20 p47 p51

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
TRANSPATHMO000000102

--

Go back
930.0, 574.0
20.0, 20.0

PKCdelta{active}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

p21 p49 p52

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000000134

--

Go back
1071.0, 454.5
25.760000000000005, 19.32

BCL10

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p21 p50

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1082.5, 613.0
18.570738579190984, 30.114711209498893

CARMA1

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p21

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
952.5, 640.0
23.38208845659754, 32.626169939438434

BCL10:MALT1:CARMA1

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p22 p23

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
938.0, 724.0
19.676470588235297, 32.794117647058826

BCL10:MALT1 oligomer:CARMA1

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p24

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1116.5, 824.0
22.00227229691346, 32.198447263775805

Bacteria

--

e36

cso30:c:Cell

cso30:i:CC_Cytosol

--

--

p25

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1032.5, 894.0
23.646725545742378, 28.95517413764373

Nod2:Bacteria

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p26

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1043.5, 382.0
16.97725900583619, 27.53069027973436

TRABID

--

e38

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p39

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
1028.5, 333.0
23.899850024995832, 29.265122479586736

TRAF6:Cezanna

--

e39

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p38

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
256.56385286230795, 244.0887646314419
919.5471383778471, 1392.8129342021095

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
997.7901183136144, 436.5797367105482
19.44975837360441, 23.81603066155641

TRAF6:TRABID

--

e40

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p39

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
418.5, 204.0
26.022847100175742, 40.03514938488576

TNFR1

--

e41

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p41

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
414.0, 1320.0
60.0, 32.0

NF-KappaB

--

e42

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p40

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
502.5, 205.0
19.27559745669809, 37.30760798070598

TNFRII

--

e43

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p42 p43

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
329.0, 899.0
14.666043030869966, 33.84471468662301

c-IAP1

--

e44

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p42 p43

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
445.0, 1236.0
46.089965397923876, 24.581314878892734

c-IAP1

--

e45

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

p46

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
778.0, 414.0
20.0, 20.0

PLCgamma{ub}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p47 p51

p53

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
TRANSPATHMO000000102

--

Go back
718.0, 674.0
20.0, 20.0

PKCdelta{ub}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49 p52

p48

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000000134

--

Go back
1051.5, 207.0
17.732734049550537, 34.32142074106556

Ligand:CD28

--

e48

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p50

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1111.0, 534.5
25.760000000000005, 19.32

BCL10{ub}

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

p50

p54

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
334.5, 214.0
18.70467002850252, 36.20258715194037

TNF-alpha:TNFR

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p1 p32 p36 p59

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
310.0969606547005, 1146.0786233087192
395.3462666636877, 358.5356273095268

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
352.797302305527, 1154.5753964471385
231.17081514413027, 347.49243550327867

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
315.250450164283, 1150.86400642476
385.039287644523, 348.9648610774449

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
315.9866629513661, 1151.6002192118438
383.5668620703561, 347.49243550327867

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
310.0969606547005, 1146.0786233087192
395.3462666636877, 358.5356273095268

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
310.0969606547005, 1146.0786233087192
395.3462666636877, 358.5356273095268

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
314.58574384996604, 1153.0011383132444
383.5668620703561, 347.49243550327867

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
598.6923731913218, 1293.3211807253624
24.69906250947442, 22.359151324366344

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
533.9056479279985, 1396.3909709170139
69.94021477290563, 63.31429968915671

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
310.0969606547005, 1146.0786233087192
395.3462666636877, 358.5356273095268

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
443.0, 491.0
17.0, 17.0

TRAF2{ub}

--

e6

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1 p43

p3 p4 p29 p44 p57

true true true true

csml-variable:Double

m6

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000209

--

Go back
403.2778512470021, 1305.408893480795
12.52003536492014, 6.028165175702296

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
402.85977182718585, 1287.431478428697
42.853140531164634, 77.13565295609631

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
420.8371868792845, 1337.6010088066453
6.689270717059835, 6.689270717059836

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1066.0, 1156.0
19.411764705882348, 32.35294117647059

p62:IKK-alpha:IKK-beta:IKK-gamma{uba]

--

e63

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p55

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
857.5, 1083.0
21.009331778036998, 25.725712381269787

p62:RIP{ub}

--

e64

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p56

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
812.5, 846.0
22.323946008998497, 27.335444092651223

TRAF2{ub}:p62

--

e65

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p57

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1088.5, 766.0
22.323946008998497, 27.335444092651223

TRAF6{ub}:p62

--

e66

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p58

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
618.0, 1351.5
60.0, 17.0

RelA-p65:DNA

--

e67

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

--

p59

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
542.0, 1439.5
60.0, 17.0

RelA-p65{ub}:DNA

--

e68

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p59

p60

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
401.0, 1394.0
21.556576680068922, 20.838024124066624

protein degradants

--

e69

cso30:c:EntityBiological

cso30:i:CC_Cytoplasm

--

p60

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
193.0416421114047, 197.0704656450339
1017.8208341536772, 1442.2258314207083

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
849.5, 1347.0
20.960339943342774, 25.66572237960339

SOCS-1:p50:RelA-p65{active}

--

e70

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p61

p62

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
793.5, 1479.0
20.960339943342774, 25.66572237960339

SOCS-1:p50:RelA-p65{ub}

--

e71

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p62

p63

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
196.6779124386394, 222.52435793567636
976.4076543229606, 1417.7439140769388

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
250.37463331126497, 235.97825022631872
971.9498177877958, 1399.1505578983006

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
378.0, 358.0
19.0, 19.0

p1

p1

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e5 MO000000209 MO000022136

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c7 : 1
stoichiometry:c3 : 1

m5*m180*m6443*0.1

nodelay

--

true

0

false

PMID: 15809659,12591926 TRAF2 and TRAF5 also contain a RING domain and UbLys63 modifications can be detected in TRAF2 on TNF-alpha stimulation

Go back
714.0, 426.0
19.0, 19.0

p10

p10

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e19 e20

MO000016963

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m19*m20*0.1

nodelay

--

true

0

false

PMID: 15809659,11460167 TRAF6 undergoes trans-auto-ubiquitination , which is strongly enhanced by its forced oligomerization PMID: 15809659,15492226 TRAF-interacting protein with forkhead-associated domain (TIFA) oligomers promote TRAF6 oligomerization and Ub ligase activity

Go back
669.0, 533.0
21.0, 21.0

p11

p11

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000000248 MO000016963

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m207*m1872*0.1

nodelay

--

true

0

false

PMID: 15809659,11460167 TRAF6 undergoes trans-auto-ubiquitination , which is strongly enhanced by its forced oligomerization PMID: 15809659,15492226 TRAF-interacting protein with forkhead-associated domain (TIFA) oligomers promote TRAF6 oligomerization and Ub ligase activity

Go back
487.0, 459.0
17.0, 17.0

p3

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e19 MO000000023

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m19*m21*0.1

nodelay

--

true

0

false

PMID: 15809659,12591926,11460167 Both TRAF2 and TRAF6 activate c-Jun amino-terminal kinase (JNK) in parallel to IKK, in a process that also depends on the assembly of UbLys63 chains

Go back
737.0, 609.0
21.0, 21.0

p4

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000016963

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m13*m1872*0.1

nodelay

--

true

0

false

PMID: 15809659 Figure 2A PMID: 15809659 Ubiquitin (Ub) ligases (shown in green) catalyse the assembly of UbLys63 chains (green) on TRAF2, TRAF6, RIP and IKK-gamma, which is thought to recruit the protein kinase TAK1 through association with TAB2 or TAB3.

Go back
646.0, 962.0
19.0, 19.0

p14

p14

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e16 MO000038724

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m16*m16910*0.1

nodelay

--

true

0

false

PMID: 15809659 Figure 2A

Go back
882.0, 746.0
19.0, 19.0

p15

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e21 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m22*m23*0.1

nodelay

--

true

0

false

PMID: 15809659 TAK1 activates the IKK complex, which subsequently targets IkappaBs for BetaTrCP-mediated UbLys48 modification. PMID: 15809659 Figure 2A

Go back
726.0, 910.0
19.0, 19.0

p14

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e23 MO000038724

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m24*m16910*0.1

nodelay

--

true

0

false

PMID: 15809659 Figure 2A

Go back
746.0, 1038.0
19.0, 19.0

p17

p17

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e25 e24

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m26*m25*0.1

nodelay

--

true

0

false

PMID: 15809659 TAK1 activates the IKK complex, which subsequently targets IkappaBs for BetaTrCP-mediated UbLys48 modification.

Go back
746.0, 1202.0
19.0, 19.0

p18

p18

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytoplasm

--

e26 e27

e10 MO000016632

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c102 : 1

m27*m28*0.1

nodelay

--

true

0

false

PMID: 15809659 Figure 2A PMID: 15809659,10983987 The ubiquitin-like PLIC may provide a link between the ubiquitination machinery and the proteasome

Go back
839.0, 323.0
17.0, 17.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e29 MO000000102

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m30*m90*0.1

nodelay

--

true

0

false

PMID: 15809659 Figure2A

Go back
298.0, 530.0
19.0, 19.0

p2

p2

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000000209 MO000000208

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m180*m179*0.1

nodelay

--

true

0

false

PMID: 15809659,15258597 In addition, TRAF2 catalyses Lys 63 polyubiquitination of receptor-interacting protein (RIP)

Go back
815.0, 479.0
17.0, 17.0

p19

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 MO000000134

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m31*m121*0.1

nodelay

--

true

0

false

PMID: 15809659 Figure2A PMID: 15809659,15122200 T-cell receptor (TCR) ligation triggers protein kinase Cdelta (PKCdelta)-mediated formation of a complex that consists of the CARMA1 (caspase recruitment domain-containing membrane-associated guanylate kinase protein 1), B-cell lymphoma 10 (BCL10) and mucosa-associated lymphoid tissue (MALT1) proteins and transmits the signal to the IKK complex

Go back
1006.0, 558.0
19.0, 19.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 MO000063418 e32 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c65 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m32*m38297*m33*m34*0.1

nodelay

--

true

0

false

MID: 15809659,15122200 T-cell receptor (TCR) ligation triggers protein kinase Cdelta (PKCdelta)-mediated formation of a complex that consists of the CARMA1 (caspase recruitment domain-containing membrane-associated guanylate kinase protein 1), B-cell lymphoma 10 (BCL10) and mucosa-associated lymphoid tissue (MALT1) proteins and transmits the signal to the IKK complex

Go back
813.0, 517.0
21.0, 21.0

p11

p22

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e34 MO000000248

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m35*m207*0.1

nodelay

--

true

0

false

PMID: 15809659,15125833 BCL10 and MALT1 can induce E3 activity of TRAF6, and RNA interference (RNAi) suggests that TRAF2 and TRAF6 are necessary for IKK activation in Jurkat T cells after TCR ligation

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1035.0, 731.0
17.0, 17.0

p23

p23

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 15809659,11262391 BCL10 induces oligomerization of MALT1 which might enhance its Ub ligase activity.

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899.0, 803.0
19.0, 19.0

p24

p24

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e35 MO000000248

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m36*m207*0.1

nodelay

--

true

0

false

PMID: 15809659,14695475 MALT1 triggers UbLys63 modification of Lys 399 in the carboxy-terminal zinc-finger domain of IKKgamma; mutation of this residue abolishes IKK/NF-KappaB activation by BCL10

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1033.0, 829.0
21.0, 21.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 MO000020461

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m37*m4947*0.1

nodelay

--

true

0

false

PMID: 15809659,15620648 Nucleotide-binding oligomerization domain 2 (NOD2), which functions as an intracellular sensor for bacteria, promotes RIP2-dependent NF-¦ÊB activation by inducing the assembly of Lys 63 polyUb chains at position Lys 285 of IKKgamma

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886.0, 970.0
19.0, 19.0

p26

p26

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e37 MO000017949 MO000000248

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m38*m2684*m207*0.1

nodelay

--

true

0

false

PMID: 15809659,15620648 Nucleotide-binding oligomerization domain 2 (NOD2), which functions as an intracellular sensor for bacteria, promotes RIP2-dependent NF-¦ÊB activation by inducing the assembly of Lys 63 polyUb chains at position Lys 285 of IKKgamma

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570.0, 1070.0
19.0, 19.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000038724 e21

MO000016632

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c84 : 1
stoichiometry:c86 : 1

m16910*m22*0.1

nodelay

--

true

0

false

PMID: 15809659,15620648 Nucleotide-binding oligomerization domain 2 (NOD2), which functions as an intracellular sensor for bacteria, promotes RIP2-dependent NF-¦ÊB activation by inducing the assembly of Lys 63 polyUb chains at position Lys 285 of IKKgamma

Go back
402.0, 1194.0
19.0, 19.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000016632

G013179

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m1617*0.1

nodelay

--

true

0

false

PMID: 15809659,15226292 Expression of CYLD is induced by NF-KappaB, which provides a novel autoregulatory feedback pathway that could limit the duration of IKK activity

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494.0, 914.0
19.0, 19.0

p29

p29

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

MO000041169 e6

MO000000209 e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m19042*m6*0.1

nodelay

--

true

0

false

PMID: 15809659,12917690,12917691,12917689 CYLD interferes with IKK/NF-KappaB signalling by catalysing the selective cleavage of UbLys63 chains from TRAF2, TRAF6 and IKKgamma, without affecting UbLys48-modified IKappaBalpha or Beta-catenin

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531.0, 491.0
17.0, 17.0

p3

p3

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e6 MO000000023

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m6*m21*0.1

nodelay

--

true

0

false

PMID: 15809659,12591926,11460167 Both TRAF2 and TRAF6 activate c-Jun amino-terminal kinase (JNK) in parallel to IKK, in a process that also depends on the assembly of UbLys63 chains

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586.0, 798.0
19.0, 19.0

p29

p30

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

MO000041169 e19

MO000000212 e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m19042*m19*0.1

nodelay

--

true

0

false

PMID: 15809659,12917690,12917691,12917689 CYLD interferes with IKK/NF-KappaB signalling by catalysing the selective cleavage of UbLys63 chains from TRAF2, TRAF6 and IKKgamma, without affecting UbLys48-modified IKappaBalpha or Beta-catenin

Go back
782.0, 806.0
19.0, 19.0

p29

p31

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

MO000041169 e21

MO000000248 e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m19042*m22*0.1

nodelay

--

true

0

false

PMID: 15809659,12917690,12917691,12917689 CYLD interferes with IKK/NF-KappaB signalling by catalysing the selective cleavage of UbLys63 chains from TRAF2, TRAF6 and IKKgamma, without affecting UbLys48-modified IKappaBalpha or Beta-catenin

Go back
410.0, 970.0
19.0, 19.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e5 MO000041169 MO000038724

MO000016632

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m5*m16910*0.1

nodelay

--

true

0

false

PMID: 15809659 Overexpression of CYLD represses NF-KappaB activation in response to various stimuli, including TNF and IL-1.

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458.0, 1082.0
19.0, 19.0

p32

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e17 MO000038724 MO000041169

MO000016632

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c109 : 1
stoichiometry:c108 : 1

m17*m16910*0.1

nodelay

--

true

0

false

PMID: 15809659 Overexpression of CYLD represses NF-KappaB activation in response to various stimuli, including TNF and IL-1.

Go back
282.0, 430.0
19.0, 19.0

p34

p34

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytoplasm

--

MO000016591 e11

MO000000208

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m1585*m11*0.1

nodelay

--

true

0

false

PMID: 15809659,15334086,15258597 The N-terminal ovarian tumour (OTU) domain of A20 contains DUB activity and catalyses the removal of UbLys63 chains from RIP and TRAF6, thereby interfering with TNFR and TLR signalling to IKKs/NF-KappaB, respectively

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398.0, 306.0
19.0, 19.0

p34

p35

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytoplasm

--

MO000016591 e19

MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m1585*m19*0.1

nodelay

--

true

0

false

PMID: 15809659,15334086,15258597 The N-terminal ovarian tumour (OTU) domain of A20 contains DUB activity and catalyses the removal of UbLys63 chains from RIP and TRAF6, thereby interfering with TNFR and TLR signalling to IKKs/NF-KappaB, respectively

Go back
337.0, 489.0
21.0, 21.0

p36

p36

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytoplasm

--

MO000016591 MO000000208 e5

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c129 : 1
stoichiometry:c118 : 1

m1585*m179*m5*0.1

nodelay

--

true

0

false

PMID: 15809659,15258597 Subsequently, the C-terminal zinc-finger domain functions as a Ub ligase that mediates UbLys48 modification of RIP and initiates its proteasomal degradation PMID: 15809659 Figure2B PMID: 15809659,12753742,15258597 Binding of TNF-alpha to TNFRI induces ubiquitination and degradation of RIP after recruitment to lipid rafts with A20 acting as the potential Ub ligase in this reaction

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289.0, 689.0
21.0, 21.0

p37

p37

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytoplasm

--

e11

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 15809659,15258597 Subsequently, the C-terminal zinc-finger domain functions as a Ub ligase that mediates UbLys48 modification of RIP and initiates its proteasomal degradation PMID: 15809659 Figure2B PMID: 15809659,11907583 TNFRII-dependent process that requires the cellular inhibitor of apoptosis protein (c-IAP1) as a Ub ligase, TRAF2 is polyubiquitinated and degraded as well

Go back
930.0, 346.0
19.0, 19.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000000212 e28

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m183*m29*0.1

nodelay

--

true

0

false

PMID: 15809659,11463333 Using sequence similarity, Cezanne and TRAF-binding domain (TRABID) have been isolated as two further potential DUBs that contain OTU domains and can interact with TRAF6

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938.0, 398.0
19.0, 19.0

p38

p39

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000000212 e38

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m183*m39*0.1

nodelay

--

true

0

false

PMID: 15809659,11463333 Using sequence similarity, Cezanne and TRAF-binding domain (TRABID) have been isolated as two further potential DUBs that contain OTU domains and can interact with TRAF6

Go back
505.0, 609.0
21.0, 21.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 e13

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m6*m13*0.1

nodelay

--

true

0

false

PMID: 15809659 Figure 2A PMID: 15809659 Ubiquitin (Ub) ligases (shown in green) catalyse the assembly of UbLys63 chains (green) on TRAF2, TRAF6, RIP and IKK-gamma, which is thought to recruit the protein kinase TAK1 through association with TAB2 or TAB3.

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515.0, 1271.0
17.0, 17.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e28

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 15809659 Ectopic expression of Cezanne downregulates NF-¦ÊB, which suggests that Cezanne interferes with IKK activation

Go back
374.0, 126.0
19.0, 19.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000289 e41

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m230*m42*0.1

nodelay

--

true

0

false

PMID: 15809659,12753742,15258597 Binding of TNF-alpha to TNFRI induces ubiquitination and degradation of RIP after recruitment to lipid rafts with A20 acting as the potential Ub ligase in this reaction

Go back
483.0, 419.0
17.0, 17.0

p42

p42

cso30:i:ME_Ubiquitination

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e43 MO000000208 e44

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c136 : 1
stoichiometry:c135 : 1

m44*m179*m45*0.1

nodelay

--

true

0

false

PMID: 15809659,11907583 TNFRII-dependent process that requires the cellular inhibitor of apoptosis protein (c-IAP1) as a Ub ligase, TRAF2 is polyubiquitinated and degraded as well

Go back
511.0, 703.0
17.0, 17.0

p42

p43

cso30:i:ME_Ubiquitination

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e43 e44 MO000000209

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m44*m45*m180*0.1

nodelay

--

true

0

false

PMID: 15809659,11907583 TNFRII-dependent process that requires the cellular inhibitor of apoptosis protein (c-IAP1) as a Ub ligase, TRAF2 is polyubiquitinated and degraded as well

Go back
586.0, 538.0
19.0, 19.0

p44

p44

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytoplasm

--

e6

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 15809659 Figure 2B PMID: 15809659,11907583 TNFRII-dependent process that requires the cellular inhibitor of apoptosis protein (c-IAP1) as a Ub ligase, TRAF2 is polyubiquitinated and degraded as well

Go back
534.0, 1310.0
19.0, 19.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

MO000016632

G010405

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m1617*0.1

nodelay

--

true

0

false

PMID: 15809659 Both gene products, A20 and c-IAP1, are upregulated by NF-¦ÊB, which indicates that an autoregulatory circuit shuts down TNF signalling in a post-inductive manner.

Go back
518.0, 1182.0
19.0, 19.0

p45

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

MO000016632

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1

m1617*0.1

nodelay

--

true

0

false

PMID: 15809659 Both gene products, A20 and c-IAP1, are upregulated by NF-¦ÊB, which indicates that an autoregulatory circuit shuts down TNF signalling in a post-inductive manner.

Go back
893.0, 429.0
21.0, 21.0

p47

p47

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytoplasm

--

MO000038234 e30

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m16459*m31*0.1

nodelay

--

true

0

false

PMID: 15809659 Itch, the Ub ligase homologue to the E6-AP C-terminal (HECT) domain, and the closely related Nedd4 protein promote ubiquitination and degradation of phospholipase Cgamma1 (PLCgamma1) and PKCdelta, both of which are essential mediators of IKK/NF-KappaB activation in T cells.

Go back
650.0, 754.0
19.0, 19.0

p53

p48

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e47

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 15809659 Itch, the Ub ligase homologue to the E6-AP C-terminal (HECT) domain, and the closely related Nedd4 protein promote ubiquitination and degradation of phospholipase Cgamma1 (PLCgamma1) and PKCdelta, both of which are essential mediators of IKK/NF-KappaB activation in T cells.

Go back
965.0, 509.0
21.0, 21.0

p47

p49

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytoplasm

--

MO000038234 e31

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m16459*m32*0.1

nodelay

--

true

0

false

PMID: 15809659 Itch, the Ub ligase homologue to the E6-AP C-terminal (HECT) domain, and the closely related Nedd4 protein promote ubiquitination and degradation of phospholipase Cgamma1 (PLCgamma1) and PKCdelta, both of which are essential mediators of IKK/NF-KappaB activation in T cells.

Go back
333.0, 693.0
21.0, 21.0

p4

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 e13

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1

m11*m13*0.1

nodelay

--

true

0

false

PMID: 15809659 Figure 2A PMID: 15809659 Ubiquitin (Ub) ligases (shown in green) catalyse the assembly of UbLys63 chains (green) on TRAF2, TRAF6, RIP and IKK-gamma, which is thought to recruit the protein kinase TAK1 through association with TAB2 or TAB3.

Go back
1094.0, 374.0
19.0, 19.0

p50

p50

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytoplasm

--

e29 e48 e32

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1

m30*m49*m33*0.1

nodelay

--

true

0

false

PMID: 15809659,15082780 Similarly, BCL10, which is downstream of PKC¦È on the route to IKKs, is modified by ubiquitination and subsequently degraded after TCR/CD28 costimulation of T cells

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893.0, 509.0
21.0, 21.0

p47

p51

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytoplasm

--

MO000017913 e30

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m2654*m31*0.1

nodelay

--

true

0

false

PMID: 15809659 Itch, the Ub ligase homologue to the E6-AP C-terminal (HECT) domain, and the closely related Nedd4 protein promote ubiquitination and degradation of phospholipase Cgamma1 (PLCgamma1) and PKCdelta, both of which are essential mediators of IKK/NF-KappaB activation in T cells.

Go back
889.0, 641.0
21.0, 21.0

p47

p52

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytoplasm

--

MO000017913 e31

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m2654*m32*0.1

nodelay

--

true

0

false

PMID: 15809659 Itch, the Ub ligase homologue to the E6-AP C-terminal (HECT) domain, and the closely related Nedd4 protein promote ubiquitination and degradation of phospholipase Cgamma1 (PLCgamma1) and PKCdelta, both of which are essential mediators of IKK/NF-KappaB activation in T cells.

Go back
666.0, 498.0
19.0, 19.0

p53

p53

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e46

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 15809659 Itch, the Ub ligase homologue to the E6-AP C-terminal (HECT) domain, and the closely related Nedd4 protein promote ubiquitination and degradation of phospholipase Cgamma1 (PLCgamma1) and PKCdelta, both of which are essential mediators of IKK/NF-KappaB activation in T cells.

Go back
722.0, 538.0
19.0, 19.0

p54

p54

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e49

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 15809659,15082780 Similarly, BCL10, which is downstream of PKC¦È on the route to IKKs, is modified by ubiquitination and subsequently degraded after TCR/CD28 costimulation of T cells

Go back
966.0, 1082.0
19.0, 19.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000022281 e21

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1

m6578*m22*0.1

nodelay

--

true

0

false

PMID: 15909659,15340068 p62 interacts through its UBA domain selectively with UbLys63-modified proteins, including TRAF6, while the N-terminal Phox and Bem1 (PB1) region provides a docking surface for the proteasome

Go back
886.0, 1026.0
19.0, 19.0

p55

p56

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000022281 e11

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c173 : 1
stoichiometry:c174 : 1

m6578*m11*0.1

nodelay

--

true

0

false

PMID: 15909659,15340068 p62 interacts through its UBA domain selectively with UbLys63-modified proteins, including TRAF6, while the N-terminal Phox and Bem1 (PB1) region provides a docking surface for the proteasome

Go back
930.0, 878.0
19.0, 19.0

p55

p57

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000022281 e6

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1

m6578*m6*0.1

nodelay

--

true

0

false

PMID: 15909659,15340068 p62 interacts through its UBA domain selectively with UbLys63-modified proteins, including TRAF6, while the N-terminal Phox and Bem1 (PB1) region provides a docking surface for the proteasome

Go back
962.0, 826.0
19.0, 19.0

p55

p58

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000022281 e19

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m6578*m19*0.1

nodelay

--

true

0

false

PMID: 15809659,15340068 p62 interacts through its UBA domain selectively with UbLys63-modified proteins, including TRAF6, while the N-terminal Phox and Bem1 (PB1) region provides a docking surface for the proteasome

Go back
578.0, 1382.0
19.0, 19.0

p59

p59

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytoplasm

--

e5 e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1

m5*m68*0.1

nodelay

--

true

0

false

PMID: 15809659,14690596,15226358 After TNF-alpha stimulation, DNA-bound p65 is subject to ubiquitination and proteasomal degradation in the nucleus¡½a process that seems to be required for abrogation of NF-kappaB activity despite IKappaBalpha re-synthesis

Go back
406.0, 750.0
19.0, 19.0

p15

p6

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e15 MO000000248

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m15*m207*0.1

nodelay

--

true

0

false

PMID: 15809659 TAK1 activates the IKK complex, which subsequently targets IkappaBs for BetaTrCP-mediated UbLys48 modification. PMID: 15809659 Figure 2A

Go back
466.0, 1446.0
19.0, 19.0

p60

p60

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytoplasm

--

e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 15809659,14690596,15226358 After TNF-alpha stimulation, DNA-bound p65 is subject to ubiquitination and proteasomal degradation in the nucleus¡½a process that seems to be required for abrogation of NF-kappaB activity despite IKappaBalpha re-synthesis

Go back
818.0, 1230.0
19.0, 19.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000016632 MO000017004 MO000016882

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c187 : 1
stoichiometry:c189 : 1
stoichiometry:c188 : 1

m1617*m1906*m155666*0.1

nodelay

--

true

0

false

PMID: 15809659,14690596 It has also been shown that suppressor of cytokine signalling 1 (SOCS1) associates with p65 in LPS-treated cells; the C-terminal SOCS domain functions as an E3 ligase to catalyse the poly-ubiquitination of p65 and its subsequent degradation

Go back
850.0, 1418.0
19.0, 19.0

p62

p62

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytoplasm

--

e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 15809659,14690596 It has also been shown that suppressor of cytokine signalling 1 (SOCS1) associates with p65 in LPS-treated cells; the C-terminal SOCS domain functions as an E3 ligase to catalyse the poly-ubiquitination of p65 and its subsequent degradation

Go back
376.0, 1080.0
23.0, 23.0

p63

p63

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e71

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c193 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 15809659,14690596 It has also been shown that suppressor of cytokine signalling 1 (SOCS1) associates with p65 in LPS-treated cells; the C-terminal SOCS domain functions as an E3 ligase to catalyse the poly-ubiquitination of p65 and its subsequent degradation

Go back
702.0, 726.0
19.0, 19.0

p15

p7

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e14 MO000000248

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m14*m207*0.1

nodelay

--

true

0

false

PMID: 15809659 TAK1 activates the IKK complex, which subsequently targets IkappaBs for BetaTrCP-mediated UbLys48 modification. PMID: 15809659 Figure 2A

Go back
422.0, 362.0
19.0, 19.0

p8

p8

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e17 MO000022136 MO000000212

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m17*m6443*m183*0.1

nodelay

--

true

0

false

PMID: 15809659,10215628 Genetic ablation has demonstrated an essential function of TRAF6 in IKK activation through IL-1 receptor (IL-1R) and Toll-like receptor (TLR) signalling PMID: 15809659,11460167 TRAF6 undergoes trans-auto-ubiquitination , which is strongly enhanced by its forced oligomerization PMID: 15809659 Figure 2A

Go back
710.0, 286.0
19.0, 19.0

p8

p9

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e18 MO000000212 MO000022136

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m18*m183*m6443*0.1

nodelay

--

true

0

false

PMID: 15809659,10215628 Genetic ablation has demonstrated an essential function of TRAF6 in IKK activation through IL-1 receptor (IL-1R) and Toll-like receptor (TLR) signalling PMID: 15809659,11460167 TRAF6 undergoes trans-auto-ubiquitination , which is strongly enhanced by its forced oligomerization PMID: 15809659 Figure 2A

Go back
350.0, 250.0

c1

c1

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
540.0, 508.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.9708219831033, 817.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
346.0, 250.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
756.0, 1221.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
432.76076249863115, 984.3625951081997

c103

c103

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
436.5894663844041, 924.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.0, 988.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
471.19732590971466, 243.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
480.86745234925706, 932.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
477.0, 1098.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
474.7652786218766, 1021.0

c109

c109

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
456.0, 508.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
295.56892908110547, 350.0

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
297.79566248376506, 456.4956168042976

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.0, 449.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
322.0, 319.94028500029066

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
424.52028859050165, 321.72860028504925

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
417.0, 316.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
314.0, 350.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
296.0, 517.4605447861927

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.0, 510.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
316.145770236779, 652.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 620.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
305.0, 710.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
549.0, 317.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.0, 305.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
949.0, 349.5983195859331

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
549.0, 318.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
964.9476708146649, 397.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
957.0, 414.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
529.5563197877415, 305.0

c127

c127

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
473.52819584881325, 1286.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 250.0

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.0, 630.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
331.0, 136.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.8141043230231, 152.03225484557382

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
354.09967694185656, 145.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
493.7648419689037, 242.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
301.0, 441.8602392019413

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
377.9653318420858, 436.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
341.0, 443.6201571908687

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
512.0, 242.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
344.0, 725.9494992849523

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
410.0, 568.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
350.9711254108328, 653.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
457.42401544305807, 515.6239195386504

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
460.0, 503.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
386.6797963138653, 557.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
560.9111899043244, 1290.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
506.8441746598661, 1329.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.3730830011045, 1199.104456000465

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
486.81174733563773, 1201.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
921.4379277528652, 446.94571396153077

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
858.0, 407.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
805.9261327642199, 426.08462869405116

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
361.73421377392077, 623.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
691.3917431422951, 431.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
388.25627549021954, 517.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
992.6916890366381, 494.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
946.0, 537.0231645833151

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
744.6744410670501, 527.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
673.1811873607643, 694.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.64248105440134, 767.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
919.5214178631247, 535.7891229716398

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
853.0, 410.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.1510741622848, 437.1151037770579

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
346.0, 714.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
917.6204395892227, 657.43493335987

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
910.0944414007566, 594.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
745.8659103802304, 654.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
857.0, 233.0

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1065.0, 241.0

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1086.0, 400.74621858967487

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1105.0, 393.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.9995325464528, 544.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
391.0816895208827, 557.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
993.0, 1092.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
371.0, 769.9691115068547

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
826.0, 628.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
985.0, 1099.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.5629838530102, 1041.6079254665553

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
377.0, 651.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.4246907579123, 1045.0

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
949.0610446266759, 903.8925986783032

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
460.0, 506.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
842.7753683745434, 864.8824576064684

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.6157888475672, 852.560267766749

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
659.0, 413.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.9966088122255, 760.2329109362784

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
981.0, 788.1922923104477

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
348.0, 250.0

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
604.1143024185452, 1369.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
576.1716813201745, 1401.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.9693977915938, 1450.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.20449602968955, 1418.0501711869565

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
766.0, 1251.3779949038617

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
843.6564023547028, 1250.437601569802

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.0, 1249.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
844.9996302031569, 1236.0

c189

c189

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
425.0, 764.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
860.0, 1373.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.2975823717737, 1437.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.7725585582105, 1108.5387334014222

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
376.40132056046866, 868.9899275220583

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.64160470913396, 384.9742299563793

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
563.0, 691.0

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
568.0, 739.3533436687499

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.5985021064149, 745.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
447.00570813538206, 232.0

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
434.1313708498985, 388.9195959492893

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
448.12347745756864, 321.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
441.0, 373.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 242.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
549.0, 297.88887195428504

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
662.2264150943396, 305.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.0, 377.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
449.0, 304.50032808975175

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
661.0, 408.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
725.4204706649821, 388.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
732.0, 445.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
560.0, 560.8599434057004

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.2093339339347, 501.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
690.0, 549.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
511.4018283195646, 408.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
511.8123804312969, 471.72241458327807

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
499.0, 476.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
324.83682160513195, 543.6075531497706

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
671.0, 620.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
752.9579993949138, 506.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
758.0, 627.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
830.0, 628.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
831.0, 684.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
838.8755378708564, 765.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
657.9169928638811, 884.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.0, 931.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.0, 981.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
753.0, 920.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
294.0, 556.9080460493155

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.0, 920.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.2456860658092, 929.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
762.7656428706189, 981.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.0, 1048.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
756.0, 1057.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
756.0, 1152.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
769.0100193633918, 1141.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
390.79959434720115, 865.5104178977563

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
848.0, 245.0

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
782.0, 332.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.0, 549.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
848.0, 340.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.1238498047111, 410.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
839.992766725465, 484.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
832.0, 495.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
950.0, 571.676232709847

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1027.3822875309102, 474.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1033.0, 568.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1031.3206812385497, 579.9039768230127

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.0513748366069, 577.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
839.9240236450528, 542.3764248207201

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
400.09505157597033, 383.1676940130167

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
568.0, 542.2063309876478

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
821.319744306791, 538.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
976.0, 668.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
966.0, 740.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
917.8201065633589, 757.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
568.0, 767.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.8261355036544, 822.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1062.0, 840.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.0, 797.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1044.0, 850.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
460.0, 500.0

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.1998505905883, 914.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.9974696555727, 980.2011942051716

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
568.0, 776.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.6041697127818, 635.837514882448

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.6292314157147, 628.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
581.9781135670801, 932.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 1089.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.76811903147814, 1207.9121523769793

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
387.91400779426596, 1213.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.3474977942105, 940.9924492668405

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
556.0, 500.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.0, 508.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
408.11814239690176, 575.7144975718738

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
391.981140011269, 860.906876520068

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
512.0, 824.3428562876811

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
598.1112009426521, 413.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
541.9074248650574, 332.9483696513358

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.84614318059573, 810.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
517.0, 827.5459262377818

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
794.0689786887838, 628.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
575.8213480118193, 769.6812243389892

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back